No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1185 |
4. Check minimum number of eventsNone |
1185 |
5. Include endpointsNone |
1185 |
6. Filter based on genotype QC (FinnGen only) |
1185 |
Control definitions (FinnGen only)
- Control exclude
- I9_DOAAC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Dissection of aorta
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10468 | 3661 | 6638 |
| Only index persons | 6613 | 2366 | 4247 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.10 | 0.19 |
| Only index persons | 0.14 | 0.09 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 69.07 | 73.63 | 66.56 |
| Only index persons | 68.47 | 73.10 | 65.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1185 | 320 | 865 |
| Unadjusted period prevalence (%) | 0.31 | 0.11 | 0.38 |
| Median age at first event (years) | 66.80 | 67.18 | 66.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1069
- Matched controls
- 10687
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I71.01
ICD-10 Finland
Aneurysm of the descending aorta
+∞
323.0
313
*
I71.09
ICD-10 Finland
Aortic dissection [regardless of location]
+∞
323.0
476
*
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
1442.7
323.0
309
*
I71.00
ICD-10 Finland
Dissecting aneurysm of aorta (ruptured) [any part]
+∞
323.0
515
*
PD5BD
NOMESCO Finland
Extensive CT of aorta
109.7
303.9
323
42
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
1518.0
253.7
237
*
I71.0
ICD-10 Finland
Dissection of aorta [any part]
+∞
207.2
192
*
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
+∞
198.3
184
*
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
568.8
196.2
189
*
PD5AD
NOMESCO Finland
CT of aorta
54.4
139.5
166
36
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
34.0
125.4
165
57
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
566.5
105.6
103
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
103.4
391
1066
WX872
NOMESCO Finland
Intensive care
10.4
102.7
214
250
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
1076.1
101.9
98
*
I71.1
ICD-10 Finland
Thoracic aortic aneurysm, ruptured
+∞
100.6
95
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
8.6
99.3
233
334
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.7
96.4
408
1237
FCC45
NOMESCO Finland
Percutaneous insertion of stent into descending aorta
+∞
90.9
86
*
AJ2
HP
Reconstruction of the ascending aorta
+∞
90.9
86
*
B01AA03
ATC
warfarin; systemic
3.8
81.8
479
1894
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
79.2
75
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
13.5
76.8
138
116
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
7.6
74.5
188
293
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.8
73.0
166
219
ZXD05
NOMESCO Finland
Urgent procedure
3.4
70.9
480
2066
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
+∞
70.6
67
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
8.5
68.8
159
215
C07AB07
ATC
bisoprolol; oral
3.1
67.1
709
4129
WX892
NOMESCO Finland
Monitored bed care
6.2
67.0
196
372
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
16.8
66.3
108
71
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
71.1
64.2
73
11
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
9.2
61.2
134
164
I71.3
ICD-10 Finland
Abdominal aortic aneurysm, ruptured
+∞
60.0
57
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
55.5
388
1637
PD6ZT
NOMESCO Finland
Stent grafting of thoracic aorta
+∞
54.6
52
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.5
53.8
213
560
FCB40
NOMESCO Finland
Resection and reconstruction of aortic arch using tube graft
+∞
53.6
51
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.1
53.0
365
1514
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
100.3
52.4
57
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
51.1
597
3433
PD5CD
NOMESCO Finland
Very extensive CT angiography of aorta
33.4
50.5
66
21
ZXE40
NOMESCO Finland
More than seven and less than nine hours
11.5
50.1
96
91
XF400
NOMESCO Finland
ECG with 12 standard connections
3.3
49.6
302
1139
FCA70
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft
256.5
48.4
49
*
205
Kela drug reimbursment
Chronic hypertension
2.6
46.3
474
2474
PD1BD
NOMESCO Finland
Extensive CT of abdominal aorta and branches
89.2
46.3
51
6
ZXE20
NOMESCO Finland
More than three and less than five hours
3.6
46.2
239
789
I70.0
ICD-10 Finland
Atherosclerosis of aorta
+∞
45.1
43
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.5
44.0
139
283
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
43.7
43.9
54
13
Q87.4
ICD-10 Finland
Marfan syndrome
445.0
43.5
43
*
C08CA01
ATC
amlodipine; oral
2.5
43.2
518
2919
FCC50
NOMESCO Finland
Resection and reconstruction of descending aorta using tube graft
+∞
41.9
40
*
FCB50
NOMESCO Finland
Resection of aortic arch and reimplantation of branches
+∞
41.9
40
*
AJ3
HP
Reconstruction of the aortic arch
+∞
41.9
40
*
4410A
ICD-9 Finland
Aortic aneurysm, Dissecting aneurysm[ANEURYSMA AORTAE DISSECANS]
+∞
40.9
39
*
PDG51
NOMESCO Finland
Bypass from aorta to iliac artery for aneurysm
+∞
37.7
36
*
Z2221
NOMESCO Finland
Medical doctor
2.6
37.5
347
1662
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
36.7
35
*
PDG05
NOMESCO Finland
Operation on infrarenal abdominal aorta for aneurysm
+∞
34.6
33
*
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
+∞
34.6
33
*
R4110
NOMESCO Finland
Physiotherapy
2.5
34.5
335
1635
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.4
32.3
348
1785
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
10.4
32.2
64
65
PDQ05
NOMESCO Finland
Insertion of endovascular graft into infrarenal abdominal aorta
+∞
31.4
30
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
31.0
393
2172
PD1AE
NOMESCO Finland
Ultrasound examination of abdominal aortta
72.1
31.0
35
5
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
17.7
29.5
46
27
I70.1
ICD-10 Finland
Atherosclerosis of renal artery
+∞
29.3
28
*
TKC20
NOMESCO Finland
Catheterisation of bladder
3.6
29.1
142
436
Q23.11
ICD-10 Finland
Bicuspid aortic valve
28.8
29.1
39
14
Z31.5
ICD-10 Finland
Genetic counselling
7.1
28.7
72
108
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
28.6
715
5237
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
28.2
27
*
B01AB05
ATC
enoxaparin; parenteral
2.2
28.1
376
2109
I71
ICD-10 Finland
Aortic aneurysm and dissection
288.7
27.9
28
*
TK800
NOMESCO Finland
Hemodialysis
9.4
27.7
58
65
PAH12
NOMESCO Finland
Bypass from common carotid artery
277.7
26.8
27
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.8
26.4
68
106
Z3231
NOMESCO Finland
Registered nurse
2.2
24.9
332
1839
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
255.8
24.8
25
*
Z3226
NOMESCO Finland
Physiotherapist
2.5
24.6
229
1066
PD5YT
NOMESCO Finland
Implantation of aorttaprothesis for aortta aneurysm
+∞
24.0
23
*
I71.6
ICD-10 Finland
Thoracoabdominal aortic aneurysm, without mention of rupture
+∞
24.0
23
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
8.2
23.2
52
66
AJ5
HP
Reconstruction of the descending thoracic aorta with a stent graft
+∞
23.0
22
*
26
HP
Aortic root """"composite graft""""
+∞
23.0
22
*
PA1BD
NOMESCO Finland
Extensive CT of aortic arch and branches
85.3
22.7
25
*
TFP20
NOMESCO Finland
Cardiodefibrillation
3.0
22.3
137
497
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
+∞
21.9
21
*
PD7ZT
NOMESCO Finland
Stent grafting of abdominal aorta
+∞
21.9
21
*
C03CA01
ATC
furosemide; systemic
2.0
21.9
422
2679
PC1BC
NOMESCO Finland
Extensive angiography of aorta and abdominal arteries
117.4
21.6
23
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
21.0
333
1954
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.6
20.9
100
301
I72.3
ICD-10 Finland
Aneurysm and dissection of iliac artery
+∞
20.9
20
*
C02AC05
ATC
moxonidine; oral
3.9
20.7
88
240
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.8
20.7
70
153
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
42.6
20.5
25
6
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
20.4
256
1359
I72.8
ICD-10 Finland
Aneurysm and dissection of other specified arteries
+∞
19.8
19
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
29.6
19.7
26
9
I31.2
ICD-10 Finland
Haemopericardium, not elsewhere classified
56.1
19.0
22
*
I72.4
ICD-10 Finland
Aneurysm and dissection of artery of lower extremity
+∞
18.8
18
*
ZXE00
NOMESCO Finland
One hour or less
1.8
18.7
413
2715
C08CA02
ATC
felodipine; oral
2.5
18.7
153
658
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
18.6
393
2543
ZXD00
NOMESCO Finland
Emergency procedure
4.5
18.3
65
150
K83
ICPC
Heart valve disease NOS
9.8
18.0
36
38
C07AB02
ATC
metoprolol; systemic
1.9
17.9
307
1837
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
17.7
406
2691
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
17.5
335
2083
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.6
17.1
135
566
C09AA05
ATC
ramipril; oral
1.9
17.1
333
2078
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
16.9
161
747
421
HP
Reconstruction of the aortic base, e.g., composite graft
+∞
16.7
16
*
AJ4
HP
Reconstruction of the descending thoracic aorta
+∞
16.7
16
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
16.6
105
386
3A064
NOMESCO Finland
NA
30.6
16.1
21
7
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.8
15.8
108
417
4410B
ICD-9 Finland
Aortic aneurysm, Dissecting aneurysm[DISSECATIO AORTAE SINE ANEURYSMATE]
+∞
15.7
15
*
I71.8
ICD-10 Finland
Aortic aneurysm of unspecified site, ruptured
+∞
15.7
15
*
C03DA01
ATC
spironolactone; oral
2.3
15.6
154
724
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
15.5
190
987
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.2
15.5
83
273
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.6
15.2
69
200
FCD60
NOMESCO Finland
Resection of thoracoabdominal aorta and reimplantation of branches
+∞
14.6
14
*
PC1AC
NOMESCO Finland
Angiography of aorta and abdominal arteries
152.0
14.5
15
*
R06.0
ICD-10 Finland
Dyspnoea
1.8
14.3
278
1719
AA1AD
NOMESCO Finland
CT of head and brain
1.8
14.2
286
1787
C08CA05
ATC
nifedipine; systemic
2.6
13.9
103
415
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
5.0
13.8
44
91
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.0
13.8
80
278
XF640
NOMESCO Finland
NA
4.1
13.8
53
133
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.2
13.8
42
83
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.0
13.7
54
139
4414A
ICD-9 Finland
Aortic aneurysm, Abdominal aneurysm without mention of rupture
+∞
13.6
13
*
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
5.8
13.5
38
68
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.1
13.4
74
249
GD1AD
NOMESCO Finland
Thorax CT examination
3.3
13.4
69
221
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
13.3
148
736
N02AX02
ATC
tramadol; systemic, rectal
1.6
13.0
437
3165
A12BA01
ATC
potassium chloride; oral
2.9
12.9
80
291
3A422
NOMESCO Finland
NA
50.6
12.9
15
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.2
12.8
39
77
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
12.7
111
491
C03AA03
ATC
hydrochlorothiazide; oral
2.2
12.7
131
630
474
NOMESCO Finland
NA
70.7
12.6
14
*
XPX00
NOMESCO Finland
Intraoperative angiography
70.7
12.6
14
*
PD1CD
NOMESCO Finland
Very extensive CT of abdominal aorta and branches
32.4
12.6
16
5
42
HP
Thoracic aortic surgery
+∞
12.5
12
*
PD6YT
NOMESCO Finland
Stenting of stenosis in thoracic aorta
+∞
12.5
12
*
PD5DM
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
12.5
12
*
AN1
HP
Coronary angiography
2.0
12.5
172
932
120
NOMESCO Finland
NA
131.5
12.5
13
*
3A149
NOMESCO Finland
NA
131.5
12.5
13
*
XF404
NOMESCO Finland
Ambulatory ECG
2.3
12.4
121
564
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.3
12.3
63
201
I97.0
ICD-10 Finland
Postcardiotomy syndrome
14.5
12.3
20
14
207
Kela drug reimbursment
Chronic arrhythmias
1.9
12.1
198
1144
R04.0
ICD-10 Finland
Epistaxis
2.4
12.1
102
444
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
11.9
11.8
21
18
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
11.7
90
371
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
6.6
11.6
29
45
K99
ICPC
Cardiovascular disease other
3.7
11.6
50
140
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
+∞
11.5
11
*
PE1AT
NOMESCO Finland
Femoral artery PTA
+∞
11.5
11
*
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
121.3
11.4
12
*
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
5.7
11.4
32
58
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.4
11.3
100
446
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.7
11.3
75
286
742
NOMESCO Finland
NA
35.4
11.3
14
*
FC1AC
NOMESCO Finland
Angiography of thoracal aortta
7.4
11.3
26
36
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
11.2
113
535
PG1PT
NOMESCO Finland
Extensive endovascular embolisation for bleeding with radiological guidance not elsewhere classified
12.9
11.2
19
15
WX870
NOMESCO Finland
Other postsurgical intensive care
8.7
11.1
23
27
PWE00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of peripheral vessels and lymphatic system
43.8
10.9
13
*
K78
ICPC
Atrial fibrillation/flutter
2.2
10.9
119
586
J01XX08
ATC
linezolid; systemic
12.1
10.9
19
16
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
10.8
85
357
AB1
HP
AVR mechanical
21.7
10.7
15
7
I74.3
ICD-10 Finland
Embolism and thrombosis of arteries of lower extremities
60.6
10.6
12
*
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
10.6
78
317
51
HP
Other heart surgery
+∞
10.4
10
*
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
+∞
10.4
10
*
PDG54
NOMESCO Finland
Bypass from aorta to femoral artery for aneurysm
+∞
10.4
10
*
PD4DG
NOMESCO Finland
Very extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
+∞
10.4
10
*
PDH51
NOMESCO Finland
Bypass from aorta to bilateral iliac arteries
+∞
10.4
10
*
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
10.4
10
*
T82.7
ICD-10 Finland
Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
23.6
10.3
14
6
C09AA02
ATC
enalapril; systemic
1.7
10.2
251
1649
WX402
NOMESCO Finland
General anaesthesia
1.9
10.1
147
813
R50.9
ICD-10 Finland
Fever, unspecified
1.9
10.0
148
822
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.1
9.9
113
566
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
20.2
9.8
14
7
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
9.6
50
163
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
9.6
174
1040
TQW11
NOMESCO Finland
Vacuum treatment of wound
5.8
9.5
26
46
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
9.2
9.5
19
21
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
9.5
199
1242
ZPB32
NOMESCO Finland
Covered dacron
100.9
9.4
10
*
PD3YT
NOMESCO Finland
Pelvic artery PTA with stent
100.9
9.4
10
*
5518
FHL
Ascending aortic aneurysm surgery, aortic valve prosthesis and coronary implantation
+∞
9.4
9
*
I74.1
ICD-10 Finland
Embolism and thrombosis of other and unspecified parts of aorta
+∞
9.4
9
*
422
HP
Ascending aortic reconstruction
+∞
9.4
9
*
424
HP
Reconstruction of the descending thoracic aorta
+∞
9.4
9
*
I77.6
ICD-10 Finland
Arteritis, unspecified
+∞
9.4
9
*
A02BC02
ATC
pantoprazole; systemic
1.5
9.4
622
5151
ZXE90
NOMESCO Finland
More than 22 hours
7.0
9.3
22
32
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.4
9.3
43
129
K84
ICPC
Heart disease other
3.2
9.3
47
151
J01MA12
ATC
levofloxacin; systemic
1.7
9.2
210
1345
C07AG02
ATC
carvedilol; oral
2.3
9.1
83
377
ZX120
NOMESCO Finland
Intravenous
2.1
9.1
104
524
I15.0
ICD-10 Finland
Renovascular hypertension
18.8
8.9
13
7
I73.9
ICD-10 Finland
Peripheral vascular disease, unspecified
18.8
8.9
13
7
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
8.0
8.9
19
24
C01BD01
ATC
amiodarone; systemic
3.0
8.8
50
171
N18.8
ICD-10 Finland
Other chronic renal failure
3.4
8.7
40
120
WW502
NOMESCO Finland
Autotransfusion
8.3
8.6
18
22
C01AA05
ATC
digoxin; systemic
1.9
8.6
131
735
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
20.2
8.5
12
6
NFQ20
NOMESCO Finland
Amputation of femur
90.7
8.4
9
*
PD4CC
NOMESCO Finland
Very extensive arterigography of lower extremity with X-ray
90.7
8.4
9
*
I70.8
ICD-10 Finland
Atherosclerosis of other arteries
90.7
8.4
9
*
PD1AD
NOMESCO Finland
CT of abdominal aorta and branches
12.9
8.4
14
11
PGH47
NOMESCO Finland
Bypass from femoral to contralateral femoral artery
+∞
8.3
8
*
PE1YT
NOMESCO Finland
Femoral or popliteal artery PTA with stent
+∞
8.3
8
*
PC5YT
NOMESCO Finland
Stenting of renal artery
+∞
8.3
8
*
I72.2
ICD-10 Finland
Aneurysm and dissection of renal artery
+∞
8.3
8
*
I72.1
ICD-10 Finland
Aneurysm and dissection of artery of upper extremity
+∞
8.3
8
*
81
HP
Angiography of the heart and coronary arteries
2.0
8.3
103
536
Z2446
NOMESCO Finland
Social worker
2.5
8.3
66
278
TK810
NOMESCO Finland
Hemofiltration
10.8
8.3
15
14
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.4
8.2
67
289
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
6.6
8.2
20
31
J98.5
ICD-10 Finland
Diseases of mediastinum, not elsewhere classified
33.6
8.1
10
*
PEC23
NOMESCO Finland
Suture of common femoral artery
33.6
8.1
10
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
17.3
8.1
12
7
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
2.8
8.1
49
179
Z50.0
ICD-10 Finland
Cardiac rehabilitation
4.6
8.0
26
57
21
HP
Aortic Valve Replacement (AVR)
22.2
8.0
11
5
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
2.3
8.0
70
313
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.5
7.9
22
41
XF402
NOMESCO Finland
ECG with work load test
1.8
7.8
125
716
R07.3
ICD-10 Finland
Other chest pain
2.0
7.8
98
511
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
7.7
60
252
I50.9
ICD-10 Finland
Heart failure, unspecified
1.7
7.7
188
1220
A11CC03
ATC
alfacalcidol; systemic
4.0
7.7
29
74
PC1CC
NOMESCO Finland
Very extensive angiography of aorta and abdominal arteries
18.5
7.6
11
6
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
11.9
7.6
13
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.5
290
2106
XFE00
NOMESCO Finland
Epicardial ultrasonography
3.2
7.5
38
123
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.0
7.5
28
71
C10AA01
ATC
simvastatin; oral
1.4
7.5
493
3999
C02CA01
ATC
prazosin; oral
3.3
7.4
35
108
PEN23
NOMESCO Finland
Plastic repair of femoral artery
80.6
7.4
8
*
PDH99
NOMESCO Finland
Other bypass from abdominal aorta or iliac artery
80.6
7.4
8
*
DKW30
NOMESCO Finland
Cauterisation of artery of internal nose
7.7
7.4
16
21
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.5
7.3
57
239
PDQ20
NOMESCO Finland
Insertion of endovascular graft into common iliac artery
+∞
7.3
7
*
PD3AT
NOMESCO Finland
Pelvic artery PTA
+∞
7.3
7
*
5526
FHL
Surgery of an unrupturated abdominal aneurysm
+∞
7.3
7
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.2
7.2
70
328
B01AB04
ATC
dalteparin; parenteral
2.5
7.2
56
234
V03AE02
ATC
sevelamer; oral
30.2
7.2
9
*
N28.0
ICD-10 Finland
Ischaemia and infarction of kidney
30.2
7.2
9
*
I38
ICD-10 Finland
Endocarditis, valve unspecified
30.2
7.2
9
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
8.0
7.1
15
19
K28
ICPC
Limited function/disability (K)
3.7
7.0
29
81
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
6.4
7.0
17
27
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.4
6.9
55
234
AP1
HP
Catheterization of the left side of the heart
3.5
6.9
30
87
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
5.9
6.9
18
31
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.3
6.9
60
266
C01DA14
ATC
isosorbide mononitrate; oral
1.6
6.9
210
1443
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
11.0
6.8
12
11
XPX08
NOMESCO Finland
Intraoperative flow measurement
9.4
6.8
13
14
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
9.4
6.8
13
14
AJX
HP
Other surgery on the heart or aorta
40.3
6.8
8
*
R31
ICD-10 Finland
Unspecified haematuria
1.7
6.7
141
877
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
6.6
23
55
S18
ICPC
Laceration/cut
1.4
6.5
387
3056
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.4
6.5
50
211
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.4
6.4
29
88
FXZ00
NOMESCO Finland
Off-pump cardiac operation
6.6
6.3
15
23
XA800
NOMESCO Finland
Neuropsychological investigation
2.7
6.3
41
156
GE1BE
NOMESCO Finland
Mediastinal ultrasound examinaiton through oesophagus
11.1
6.3
11
10
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
3.9
6.3
24
63
WX882
NOMESCO Finland
High dependency care
3.1
6.3
32
106
S97
ICPC
Chronic ulcer skin
2.3
6.3
56
253
PCQ99
NOMESCO Finland
Insertion of endovascular graft into other visceral artery
+∞
6.3
6
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
+∞
6.3
6
*
PFG26
NOMESCO Finland
Operation for aneurysm of popliteal artery
+∞
6.3
6
*
PCG04
NOMESCO Finland
Operation for aneurysm of supracoeliac or juxtarenal abdominal aorta
+∞
6.3
6
*
7598B
ICD-9 Finland
Other and unspecified congenital anomalies, Other specified anomalies[SYNDROMA MARFAN]
+∞
6.3
6
*
PEF24
NOMESCO Finland
Thrombendarterectomy of deep femoral artery
+∞
6.3
6
*
I71.5
ICD-10 Finland
Thoracoabdominal aortic aneurysm, ruptured
+∞
6.3
6
*
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
+∞
6.3
6
*
FCA96
NOMESCO Finland
Other repair of ascending aorta
+∞
6.3
6
*
PD1YT
NOMESCO Finland
Implantaion of endoprothesis to aortta in conjunction to PTA
+∞
6.3
6
*
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
+∞
6.3
6
*
JN4BD
NOMESCO Finland
Extensive body CT
1.8
6.2
113
674
M01AH05
ATC
etoricoxib; oral
0.7
6.2
304
3845
XX3DW
NOMESCO Finland
Time consuming IT work
1.8
6.2
97
551
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.1
809
7319
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint I9_AORTDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AORTDIS | 2.063 [1.73, 2.46] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.644 |
During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 1366 females with I9_AORTDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AORTDIS | 1.802 [1.59, 2.04] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1145 out of 3086 males with I9_AORTDIS died.
Mortality risk
Mortality risk for people of age
years, who have I9_AORTDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.165% | 0.341% |
| 5 | 1.303% | 1.92% |
| 10 | 3.107% | 5.296% |
| 15 | 5.893% | 9.595% |
| 20 | 10.804% | 16.203% |
Relationships between endpoints
↥Index endpoint: I9_AORTDIS – Dissection of aorta
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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