No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
663 |
4. Check minimum number of eventsNone |
663 |
5. Include endpointsNone |
663 |
6. Filter based on genotype QC (FinnGen only) |
663 |
Control definitions (FinnGen only)
- Control exclude
- K11_OESSTODUO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K22
- Name in latin
- Achalasia cardiae
Similar endpoints
↥List of similar endpoints to
Achalasia of cardia
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5195 | 2402 | 2748 |
| Only index persons | 4286 | 2011 | 2275 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.08 |
| Only index persons | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 56.29 | 57.84 | 54.84 |
| Only index persons | 53.34 | 54.74 | 52.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 663 | 324 | 339 |
| Unadjusted period prevalence (%) | 0.13 | 0.11 | 0.15 |
| Median age at first event (years) | 54.15 | 50.77 | 57.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 600
- Matched controls
- 5999
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K22.0
ICD-10 Finland
Achalasia of cardia
+∞
323.0
482
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
29.2
273.3
451
564
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
593.0
182.5
172
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
53.2
135.2
161
41
R13
ICD-10 Finland
Dysphagia
27.4
133.2
188
98
K22.2
ICD-10 Finland
Oesophageal obstruction
+∞
95.4
89
*
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
146.0
94.2
98
8
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
28.4
90.6
125
55
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
985.8
89.1
85
*
JCE21
NOMESCO Finland
Laparoscopic cardiomyotomy
+∞
82.2
77
*
A02BC05
ATC
esomeprazole; systemic
4.9
71.0
353
1361
K22.1
ICD-10 Finland
Ulcer of oesophagus
750.2
69.5
67
*
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
49.1
67.1
81
19
53009
ICD-8 Finland
Diseases of oesophagus, Functio laesa NUD
+∞
66.9
63
*
UJD02
NOMESCO Finland
Gastroscopy
18.0
54.8
87
56
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
14.3
52.7
92
75
A02BC02
ATC
pantoprazole; systemic
4.1
52.6
457
2625
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
231.1
42.5
43
*
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
225.3
41.4
42
*
53001
ICD-8 Finland
Diseases of oesophagus, Achalasia cardiae
+∞
41.1
39
*
A02BC03
ATC
lansoprazole; oral
3.6
41.0
242
948
K22.9
ICD-10 Finland
Disease of oesophagus, unspecified
+∞
40.0
38
*
UJC12
NOMESCO Finland
Flexible oesophagoscopy
69.3
39.7
45
7
A02BA02
ATC
ranitidine; systemic
3.9
36.8
181
600
5300A
ICD-9 Finland
Diseases of oesophagus, Achalasia and cardiospasm
+∞
29.4
28
*
A02BC01
ATC
omeprazole; systemic
3.0
28.5
213
935
A03FA02
ATC
cisapride; oral, rectal
5.6
28.3
87
176
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
30.2
27.9
37
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
26.3
301
1690
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
26.0
237
1163
K22.7
ICD-10 Finland
Barrett oesophagus
97.8
25.9
28
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
25.9
207
938
C08CA05
ATC
nifedipine; systemic
5.0
25.2
85
190
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
260.3
24.9
25
*
A02BC04
ATC
rabeprazole; oral
4.9
22.7
78
178
K30
ICD-10 Finland
Functional dyspepsia
5.7
22.1
66
128
T18.1
ICD-10 Finland
Foreign body in oesophagus
23.3
21.9
31
14
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
62.3
21.0
24
*
UJF32
NOMESCO Finland
Coloscopy
2.6
20.2
177
827
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
+∞
19.9
19
*
K20
ICD-10 Finland
Oesophagitis
28.9
18.9
25
9
1323
FHL
Esophagoscopy and dilatation
+∞
18.8
18
*
WX002
NOMESCO Finland
Sedation and analgesia
2.7
18.5
146
636
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
185.2
17.6
18
*
XJC00
NOMESCO Finland
Oesophageal manometry
92.7
16.6
18
*
XJC10
NOMESCO Finland
Oesophageal pH monitoring
174.6
16.6
17
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.8
16.2
118
488
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
15.9
148
699
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.1
15.7
92
329
JBW97
NOMESCO Finland
Other laparoscopic operation on diaphragm or laparoscopic or thoracoscopic operation for gastro-oesophageal reflux
+∞
15.7
15
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
11.2
15.6
29
27
K29.1
ICD-10 Finland
Other acute gastritis
164.1
15.5
16
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
15.1
73
227
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.6
14.9
52
120
ZXC96
NOMESCO Finland
Robot assisted procedure
6.7
14.7
37
58
K22.3
ICD-10 Finland
Perforation of oesophagus
+∞
14.6
14
*
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
82.1
14.6
16
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
14.5
123
552
N02AX02
ATC
tramadol; systemic, rectal
2.0
14.4
265
1695
J01MA12
ATC
levofloxacin; systemic
2.5
14.2
126
578
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
14.2
166
878
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
13.8
146
731
K29.3
ICD-10 Finland
Chronic superficial gastritis
34.9
13.6
17
5
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
143.1
13.5
14
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
13.3
100
416
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
13.1
164
887
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
12.9
111
500
N02BE01
ATC
paracetamol; systemic, rectal
2.2
12.6
501
4194
K29.7
ICD-10 Finland
Gastritis, unspecified
13.5
12.5
21
16
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
12.4
159
866
Y0599
ICD-8 Finland
Investigation of digestive system
8.6
11.9
25
30
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
30.7
11.7
15
5
TJX90
NOMESCO Finland
Other minor procedure in gastroenterological surgery
66.3
11.6
13
*
6241
FHL
Fund application (Nissen)
+∞
11.5
11
*
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
+∞
11.5
11
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
11.5
266
1806
K22.8
ICD-10 Finland
Other specified diseases of oesophagus
122.2
11.5
12
*
R53
ICD-10 Finland
Malaise and fatigue
2.2
11.4
131
678
A07AA02
ATC
nystatin; oral
3.5
11.2
53
163
JDB10
NOMESCO Finland
Percutaneous gastrostomy
10.3
11.1
21
21
K29.4
ICD-10 Finland
Chronic atrophic gastritis
44.2
11.0
13
*
WX402
NOMESCO Finland
General anaesthesia
2.3
10.7
105
504
53094
ICD-8 Finland
Diseases of oesophagus, Oesophagitis
+∞
10.4
10
*
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
+∞
10.4
10
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
10.3
135
737
J01MA02
ATC
ciprofloxacin; systemic
1.8
10.3
235
1568
G47.3
ICD-10 Finland
Sleep apnoea
2.1
10.0
127
683
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
10.0
109
546
K59.09
ICD-10 Finland
Constipation, unspecified
3.4
10.0
49
155
M79.6
ICD-10 Finland
Pain in limb
1.9
10.0
200
1276
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.1
10.0
38
97
R01AD08
ATC
fluticasone; nasal
1.9
9.9
162
961
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
9.9
126
678
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.5
9.9
34
79
R4110
NOMESCO Finland
Physiotherapy
1.9
9.7
162
967
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
9.7
130
713
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
8.0
9.7
21
27
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
9.6
87
400
R42
ICD-10 Finland
Dizziness and giddiness
2.0
9.5
134
750
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.3
9.5
95
458
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.8
9.5
60
227
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
+∞
9.4
9
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
9.3
138
787
WX110
NOMESCO Finland
Local anesthesy
1.7
9.2
381
3015
N03AX16
ATC
pregabalin; oral
2.0
9.2
136
776
R4190
NOMESCO Finland
Nutritional therapy
4.7
9.2
30
66
GD1AD
NOMESCO Finland
Thorax CT examination
3.8
9.1
37
101
1310
FHL
Esophagogastroscopy
37.3
9.0
11
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
9.0
83
386
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
5.9
9.0
24
42
R03AC02
ATC
salbutamol; inhalant
1.7
9.0
292
2151
R06.0
ICD-10 Finland
Dyspnoea
1.9
8.8
142
834
N06AX11
ATC
mirtazapine; oral
1.8
8.8
176
1118
JN4BD
NOMESCO Finland
Extensive body CT
2.4
8.7
74
331
A01
ICPC
Pain general/multiple sites
2.9
8.7
51
184
J01FA09
ATC
clarithromycin; systemic
1.8
8.7
175
1111
C01DA14
ATC
isosorbide mononitrate; oral
2.1
8.6
102
532
K59.1
ICD-10 Finland
Functional diarrhoea
3.8
8.6
35
96
D21
ICPC
Swallowing problem
9.2
8.6
17
19
R06AE07
ATC
cetirizine; oral
1.7
8.5
230
1600
A02BA04
ATC
nizatidine; systemic
2.9
8.4
50
182
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.0
8.4
119
664
N06AA09
ATC
amitriptyline; systemic
2.7
8.4
57
225
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
+∞
8.3
8
*
5308A
ICD-9 Finland
Diseases of oesophagus, Other specified disorders of oesophagus[HERNIA HIATUS OESOPHAGI (""""SLIDING HERNIA"""")]
+∞
8.3
8
*
R11
ICD-10 Finland
Nausea and vomiting
3.0
8.3
48
171
J01DA01
ATC
[U] cefalexin; systemic
1.7
8.3
357
2815
K92.1
ICD-10 Finland
Melaena
3.6
8.1
35
101
A01AB09
ATC
miconazole; local oral
2.6
8.1
61
254
UKC02
NOMESCO Finland
Cystoscopy
2.0
8.1
102
545
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.7
8.1
55
218
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
7.9
117
662
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
7.9
54
214
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
6.2
7.9
20
33
R02
ICPC
Shortness of breath/dyspnoea
2.3
7.9
71
326
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
7.8
104
565
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
7.8
100
534
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
7.8
68
308
UJF92
NOMESCO Finland
Capsular endoscopy
6.5
7.8
19
30
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
3.9
7.8
30
79
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
7.7
102
555
UJF30
NOMESCO Finland
Ileoscopy through colon
2.7
7.7
52
203
C03CA01
ATC
furosemide; systemic
1.7
7.6
179
1186
N03AX12
ATC
gabapentin; oral
2.1
7.3
83
422
H02AB06
ATC
prednisolone; systemic
1.6
7.3
262
1941
Z01.9
ICD-10 Finland
Special examination, unspecified
3.1
7.3
39
133
JCE20
NOMESCO Finland
Cardiomyotomy
+∞
7.3
7
*
JCA96
NOMESCO Finland
Other local operation on oesophagus
+∞
7.3
7
*
6302
FHL
Esophagogastromyotomy (Heller)
+∞
7.3
7
*
K92.0
ICD-10 Finland
Haematemesis
5.6
7.3
20
37
A02BX02
ATC
sucralfate; oral
3.7
7.3
30
84
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
7.3
26
64
WZC30
NOMESCO Finland
Teaching
2.1
7.2
80
402
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
20.3
7.1
10
5
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
7.1
188
1283
N05CF01
ATC
zopiclone; oral
1.7
7.1
184
1249
R03DC03
ATC
montelukast; oral
2.0
7.0
87
460
R51.80
ICD-10 Finland
Headache
2.1
7.0
75
374
R03BB04
ATC
tiotropium bromide; inhalant
2.3
6.9
65
305
46699
ICD-8 Finland
Acute bronchitis and bronchiolitis
7.7
6.9
15
20
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.9
86
457
R03BA05
ATC
fluticasone; inhalant
1.9
6.8
109
635
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.8
102
580
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.4
6.8
23
54
G04BD08
ATC
solifenacin; oral
2.7
6.8
44
170
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
6.8
81
421
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.8
6.8
128
790
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
6.8
43
163
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.7
64
303
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
6.7
63
294
R07.3
ICD-10 Finland
Other chest pain
2.4
6.7
56
249
J01DB01
ATC
cefalexin; oral
1.6
6.7
450
3877
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
6.6
50
211
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
6.6
86
465
UJC02
NOMESCO Finland
Rigid oesophagoscopy
10.2
6.6
12
12
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.8
6.5
40
150
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.5
103
599
SPAT1104
SPAT
Monitoring of emergency patient
2.6
6.5
45
180
R01AD09
ATC
mometasone; nasal
1.6
6.5
237
1756
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
6.5
41
155
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
6.4
179
1231
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.8
6.4
38
139
K22
ICD-10 Finland
Other diseases of oesophagus
70.6
6.4
7
*
D06
ICPC
Abdominal pain localized other
2.5
6.4
48
200
P01AB01
ATC
metronidazole; oral, rectal
1.6
6.4
203
1446
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
6.4
272
2087
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.4
177
1217
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
6.3
78
411
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
6.3
205
1469
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
6.3
91
511
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
6.3
48
204
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
+∞
6.3
6
*
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
+∞
6.3
6
*
K22.5
ICD-10 Finland
Diverticulum of oesophagus, acquired
+∞
6.3
6
*
K25.3
ICD-10 Finland
Gastric ulcer, Acute without haemorrhage or perforation
+∞
6.3
6
*
N03AE01
ATC
clonazepam; systemic
2.9
6.3
36
129
R12
ICD-10 Finland
Heartburn
2.7
6.2
40
153
49300
ICD-8 Finland
Asthma, bronchiale
4.6
6.2
20
45
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
6.2
200
1428
A28
ICPC
Limited function/disability NOS
1.9
6.2
92
523
J02AC01
ATC
fluconazole; systemic
1.6
6.2
197
1404
D03
ICPC
Heartburn
3.8
6.1
24
65
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
6.1
95
549
A01AB04
ATC
amphotericin B; local oral
2.8
6.1
36
132
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.6
6.1
43
175
L28
ICPC
Limited function/disability (L)
1.9
6.0
94
540
N05AH04
ATC
quetiapine; oral
1.9
6.0
87
488
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
351
2191
2.28
23.73
4.7
4.3
35.1
35.3
g/l
0.31
335
2041
437
3045
2.28
21.87
7.0
4.5
6.4
6.7
mmol/l
3.12
424
2849
217
1214
2.17
18.11
2.9
2.2
—
—
—
0
0
248
1488
2.07
17.01
3.7
2.2
62.1
56.3
u/l
1.18
238
1379
503
3938
2.15
15.78
8.7
7.2
77.6
78.2
u/l
0.11
485
3682
349
2409
1.95
15.66
4.6
3.9
—
—
—
0
0
368
2621
1.91
14.67
7.1
6.0
11.4
11.6
umol/l
0.19
353
2491
293
1991
1.85
13.04
5.2
3.5
53.2
46.1
ng/l
0.11
219
1413
66
254
2.78
12.35
11.4
9.6
24.8
24.7
mmol/l
0.08
61
240
474
3778
1.89
12.17
4.7
3.8
13.7
12.6
mm/h
0.79
436
3459
202
1254
1.88
11.73
2.7
2.0
3.0
3.1
mg/l
0.19
178
1059
147
827
2.00
11.41
3.6
3.2
0.8
0.8
mmol/l
0.66
141
774
351
2586
1.76
11.39
8.3
6.5
1.2
1.2
mmol/l
1.13
304
2169
383
2898
1.76
11.27
9.1
9.2
4.3
4.2
e9/l
0.32
350
2529
322
2337
1.73
10.83
7.5
5.9
1.2
1.2
mmol/l
1.50
294
2108
567
4889
2.10
10.43
20.1
13.2
79.7
79.5
ml/min/173m2
0.07
502
4015
284
2014
1.72
10.21
2.2
2.2
80.2
77.4
nmol/l
0.71
253
1793
149
875
1.91
10.08
2.3
1.8
—
—
—
0
0
420
3326
1.72
9.91
3.7
2.8
53.7
47.1
u/l
0.61
396
3112
120
668
1.97
9.47
28.5
27.6
1.5
1.4
inr
0.14
12
87
107
574
2.03
9.37
9.3
7.0
1.3
1.3
mmol/l
0.02
90
452
66
292
2.40
9.28
4.1
3.6
1.7
2.0
mmol/l
0.24
53
215
117
666
1.92
8.61
4.7
5.3
1.0
1.0
mmol/l
0.28
109
607
104
571
1.97
8.50
3.6
4.7
242.5
261.2
u/l
0.51
97
542
44
167
2.75
8.46
4.1
2.9
—
—
—
0
0
289
2135
1.63
8.42
3.2
2.6
118.1
137.1
ug/l
0.83
267
1950
169
1090
1.74
8.24
1.8
1.7
0.9
1.2
mg/l
1.38
141
844
73
356
2.18
8.18
1.7
1.6
—
—
—
0
0
225
1570
1.66
8.17
2.6
2.0
161.6
234.9
u/l
1.42
210
1480
154
975
1.75
7.99
2.0
1.8
1055.8
1218.1
nmol/l
1.50
117
729
280
2087
1.59
7.66
2.2
1.9
89.9
93.9
pmol/l
0.77
149
1067
415
3396
1.59
7.54
5.8
4.4
41.0
1667.6
e6/l
—
6
68
594
5354
2.05
7.53
26.6
16.1
139.5
139.7
mmol/l
1.26
582
5204
221
1570
1.61
7.32
3.6
3.0
1276.7
1593.3
ng/l
0.81
195
1353
579
5185
1.92
7.31
24.1
13.8
24.2
25.1
mg/l
0.29
510
4053
459
3869
1.61
7.16
4.5
3.8
15.0
14.9
pmol/l
0.71
414
3489
593
5368
1.99
7.02
26.6
16.2
4.0
4.0
mmol/l
1.20
581
5214
169
1138
1.65
6.88
3.1
2.5
5.3
5.6
e6/l
0.14
150
1014
48
211
2.37
6.87
2.1
1.8
—
—
—
0
0
33
121
2.82
6.80
1.5
1.4
262.1
294.1
ug/g
0.38
20
65
111
668
1.79
6.78
2.4
2.5
18.8
22.6
%
2.71
103
568
205
1485
1.55
6.04
3.7
3.0
0.5
0.6
e6/l
0.06
172
1133
114
716
1.72
5.97
2.4
2.4
2.4
2.3
g/l
1.01
107
664
33
130
2.62
5.96
1.4
1.6
—
—
—
0
0
60
307
2.05
5.95
1.5
1.4
—
—
—
0
0
28
102
2.82
5.86
2.6
2.2
127.7
128.6
g/l
0.06
22
80
31
120
2.66
5.79
1.5
1.5
—
—
—
0
0
89
528
1.79
5.68
2.4
2.4
7.3
9.0
umol/l
0.59
72
458
43
197
2.26
5.63
1.8
1.6
—
—
—
0
0
601
5547
1.89
5.49
13.1
9.8
26.7
25.9
u/l
0.47
584
5339
233
1767
1.49
5.43
2.7
3.3
2.3
2.3
mmol/l
0.98
200
1545
119
779
1.64
5.31
2.4
2.4
11.7
12.8
umol/l
0.74
114
715
60
323
1.94
5.18
1.8
1.7
—
—
—
0
0
141
976
1.56
4.98
4.4
3.7
2042.9
280.6
ng/l
0.48
112
779
24
89
2.76
4.89
1.6
1.6
—
—
—
0
0
246
1919
1.45
4.85
3.9
3.1
—
—
—
0
0
179
1313
1.50
4.82
2.6
2.8
349.8
7354.4
umol/l
5.10
152
1139
18
57
3.22
4.79
1.4
1.3
—
—
—
0
0
19
64
3.03
4.59
1.2
1.1
—
—
—
0
0
91
577
1.67
4.58
4.0
3.4
—
—
—
0
0
521
4696
1.51
4.52
5.5
4.5
1.9
2.2
mu/l
0.67
482
4270
74
446
1.74
4.48
2.5
2.3
3.9
7.8
ug/l
3.10
59
388
142
1010
1.52
4.40
1.3
1.2
0.8
1.6
u/ml
1.53
41
267
303
2497
1.39
4.23
5.0
3.6
0.0
0.0
estimate
0.00
71
502
92
598
1.63
4.21
2.1
1.8
—
—
—
0
0
306
2529
1.39
4.18
5.0
3.6
0.0
0.0
estimate
0.00
74
485
72
441
1.71
4.13
2.9
2.9
212.6
228.3
ng/l
0.11
66
406
23
92
2.55
4.09
2.7
2.7
3.6
4.4
e9/l
1.65
23
92
302
2502
1.38
4.02
6.9
4.8
0.0
0.0
estimate
0.50
73
499
75
470
1.67
3.96
3.8
3.6
3.2
1.9
mmol/l
2.22
59
372
47
257
1.89
3.92
2.6
3.7
4.5
4.5
pmol/l
0.09
38
224
28
126
2.28
3.88
3.6
3.1
0.8
0.9
nmol/l
0.56
18
109
359
3072
1.37
3.84
3.2
2.9
—
—
—
0
0
72
450
1.67
3.84
3.7
2.3
43.3
31.2
u/l
1.30
63
379
15
49
3.11
3.82
1.3
2.0
—
—
—
0
0
26
115
2.31
3.76
1.3
1.4
—
—
—
0
0
28
128
2.24
3.75
2.6
2.0
2.0
1997.5
u/l
—
5
49
35
176
2.04
3.70
1.3
1.3
0.2
2.1
u/ml
—
5
13
115
812
1.50
3.66
1.3
1.2
21.6
38.4
iu/ml
1.70
47
252
61
370
1.71
3.64
2.5
2.1
13.4
13.1
nmol/l
0.14
51
334
516
4708
1.43
3.61
22.8
14.8
39.4
39.9
%
0.58
351
3329
23
98
2.40
3.61
2.7
3.0
54.8
58.7
%
0.77
23
98
162
1227
1.42
3.59
1.7
1.5
19.7
20.3
nmol/l
0.23
145
1030
148
1103
1.44
3.58
1.7
1.7
490.8
6362037.7
pmol/l
0.50
117
896
27
125
2.21
3.52
1.6
1.5
—
—
—
0
0
124
896
1.47
3.52
2.8
2.7
1.3
1.1
e6/l
0.18
73
523
25
112
2.28
3.52
3.8
2.4
16.2
16.0
%
0.08
17
56
611
5790
1.70
3.42
33.2
20.4
132.4
135.6
g/l
5.47
602
5693
110
781
1.49
3.41
1.5
1.5
—
—
—
0
0
15
53
2.87
3.37
1.3
1.9
—
—
—
0
0
26
121
2.20
3.36
1.6
1.4
—
—
—
0
0
89
606
1.54
3.35
2.2
1.8
—
—
—
0
0
73
477
1.60
3.28
3.9
3.6
6.0
5.8
kpa
0.75
73
463
11
33
3.37
3.20
2.0
1.5
—
—
—
0
0
63
401
1.63
3.16
3.6
2.6
4.2
4.4
kpa
0.28
63
386
14
50
2.84
3.10
1.4
1.7
—
—
—
0
0
14
50
2.84
3.10
1.4
1.7
—
—
—
0
0
14
50
2.84
3.10
1.4
1.7
—
—
—
0
0
14
51
2.78
3.00
2.6
4.5
—
—
—
0
0
197
1584
1.35
2.98
3.7
3.9
5.6
9.5
mg/mmol
1.49
114
993
175
1385
1.36
2.93
5.2
3.8
0.0
0.0
estimate
0.50
71
473
196
1583
1.34
2.87
3.4
3.0
7.3
7.7
mmol/l
0.46
163
1321
40
231
1.78
2.86
1.6
2.1
1.7
1.6
g/l
0.25
32
201
29
152
1.95
2.79
3.5
1.7
—
—
—
0
0
63
414
1.58
2.79
3.2
2.6
70.6
65.6
ml/min/173m2
0.30
22
167
39
226
1.77
2.77
1.1
1.0
—
—
—
0
0
68
456
1.55
2.76
4.5
4.0
1.2
1.2
mmol/l
0.64
62
394
113
843
1.41
2.70
3.1
2.9
2.2
1.6
e6/l
0.42
65
472
22
106
2.11
2.65
1.3
1.4
—
—
—
0
0
473
4333
1.32
2.65
26.3
17.2
13.8
13.7
%
1.16
466
4252
16
67
2.42
2.65
1.9
1.5
—
—
—
0
0
75
519
1.50
2.64
2.9
4.4
3.3
19.3
ug/l
1.26
61
435
7
15
4.70
2.60
1.3
1.0
—
—
—
0
0
8
20
4.04
2.57
1.6
2.0
—
—
—
0
0
8
20
4.04
2.57
1.6
2.0
—
—
—
0
0
80
568
1.46
2.49
1.9
1.7
1.6
1.4
%
0.92
73
493
15
63
2.41
2.48
1.2
1.3
—
—
—
0
0
19
89
2.17
2.47
1.8
1.5
—
—
—
0
0
8
21
3.84
2.47
1.6
2.0
—
—
—
0
0
518
4826
1.34
2.45
6.4
5.6
39.6
39.8
mmol/mol
0.19
484
4472
14
58
2.44
2.38
1.1
1.4
—
—
—
0
0
32
184
1.78
2.36
6.2
3.6
1.8
1.3
mmol/l
0.42
32
179
14
59
2.40
2.30
1.1
1.5
—
—
—
0
0
14
59
2.40
2.30
1.1
1.5
—
—
—
0
0
14
59
2.40
2.30
1.1
1.5
—
—
—
0
0
16
72
2.25
2.29
1.5
1.2
2.9
3.1
u/ml
—
7
24
14
60
2.36
2.23
1.1
1.5
—
—
—
0
0
17
80
2.15
2.20
1.9
1.5
—
—
—
0
0
524
4916
1.31
2.17
4.2
3.8
1.3
1.3
mmol/l
0.50
478
4456
27
153
1.80
2.11
7.1
3.4
3.9
4.0
mmol/l
0.63
27
137
231
1977
1.26
2.08
5.5
3.8
—
—
—
0
0
15
69
2.20
2.06
2.1
1.5
—
—
—
0
0
44
289
1.56
2.01
1.3
1.2
91.4
146.4
iu/ml
0.40
16
121
537
5071
1.31
2.00
5.1
4.4
5.9
6.0
mmol/l
1.17
490
4588
136
1096
1.30
1.97
5.7
4.0
1.0
1.0
kg/l
0.09
27
142
8
27
2.99
1.94
1.6
1.8
—
—
—
0
0
8
27
2.99
1.94
1.6
1.8
—
—
—
0
0
8
27
2.99
1.94
1.6
1.8
—
—
—
0
0
8
27
2.99
1.94
1.6
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
173
1.71
1.93
2.5
2.3
0.3
0.4
u/ml
0.11
19
94
55
384
1.47
1.90
3.0
3.7
76.0
89.5
ng/l
1.01
45
324
16
79
2.05
1.86
1.0
1.1
—
—
—
0
0
13
59
2.23
1.85
1.2
1.5
—
—
—
0
0
27
161
1.71
1.81
2.2
1.6
—
220.0
—
0
6
86
658
1.35
1.79
10.7
7.1
—
—
—
0
0
10
41
2.46
1.76
1.0
1.0
—
—
—
0
0
20
110
1.84
1.74
1.2
1.1
—
—
—
0
0
19
103
1.87
1.73
1.2
1.3
2.9
63.9
e6/l
0.67
13
83
19
103
1.87
1.73
1.2
1.3
137.1
1153.3
e6/l
0.50
14
87
11
49
2.27
1.64
1.8
1.3
149950.0
27171.4
e6/l
—
6
27
6
20
3.02
1.58
1.2
1.0
—
—
—
0
0
19
107
1.80
1.56
1.6
1.3
—
—
—
0
0
15
78
1.94
1.55
1.5
1.7
—
—
—
0
0
97
778
1.29
1.47
1.4
1.2
31.7
13.3
u/ml
0.78
32
286
19
110
1.75
1.44
1.5
1.2
30.9
11.9
u/ml
—
6
20
6
22
2.74
1.43
2.7
5.1
—
—
—
0
0
14
75
1.89
1.35
1.0
1.1
274.2
246.9
u/ml
—
6
44
121
1009
1.24
1.34
2.5
3.1
2.4
2.5
mmol/l
0.75
108
900
24
152
1.60
1.33
1.3
1.2
—
—
—
0
0
6
24
2.51
1.30
1.2
2.8
—
—
—
0
0
24
153
1.59
1.30
1.2
1.2
—
—
—
0
0
13
69
1.90
1.29
2.8
2.0
87.0
89.4
%
0.44
13
69
5
18
2.79
1.28
1.4
3.6
742.2
962.4
u/ml
—
5
18
11
55
2.02
1.28
1.9
1.4
—
—
—
0
0
54
704
0.75
1.26
1.6
1.5
—
—
—
0
0
24
155
1.57
1.24
1.2
1.2
—
—
—
0
0
11
56
1.98
1.22
1.0
1.4
195.3
274.3
pmol/l
—
6
48
13
71
1.85
1.20
1.8
1.4
—
—
—
0
0
6
26
2.32
1.19
1.3
1.3
—
—
—
0
0
12
64
1.89
1.18
1.2
1.1
—
—
—
0
0
21
134
1.59
1.15
1.5
1.6
—
—
—
0
0
76
612
1.27
1.15
4.6
4.3
34.3
31.9
%
0.97
54
394
27
184
1.49
1.12
2.2
3.1
3.2
3.2
g/l
0.03
20
150
7
31
2.27
1.10
1.3
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.3
—
—
—
0
0
5
21
2.39
1.09
1.4
1.2
—
—
—
0
0
5
21
2.39
1.09
1.4
1.2
—
—
—
0
0
8
41
1.96
1.09
2.3
1.4
—
—
—
0
0
29
203
1.45
1.07
1.9
1.9
43.4
38.9
u/l
0.79
23
179
17
105
1.64
1.07
2.1
1.8
445.2
6.7
iu/l
—
7
32
11
60
1.85
1.03
1.0
1.1
—
—
—
0
0
9
47
1.93
1.02
2.4
2.3
—
—
—
0
0
26
180
1.46
1.02
5.2
4.6
31.9
60.9
mg/l
1.82
18
141
26
180
1.46
1.02
5.2
4.6
23.9
31.7
mg/l
1.15
18
143
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
529
5105
1.18
0.95
4.7
4.2
1.4
1.5
mmol/l
0.39
483
4660
16
102
1.58
0.91
1.2
1.2
3.8
3.6
mmol/l
0.48
16
96
27
194
1.41
0.89
2.2
3.0
7.5
7.4
g/l
0.14
22
154
27
194
1.41
0.89
2.2
3.0
—
—
—
0
0
27
194
1.41
0.89
2.2
3.0
3.8
3.6
g/l
0.25
20
147
6
30
2.01
0.87
1.0
1.0
—
—
—
0
0
12
72
1.68
0.85
2.7
2.1
31.2
32.5
pg
0.45
12
72
19
129
1.49
0.84
1.2
1.2
—
—
—
0
0
213
1945
1.14
0.84
5.2
4.9
2.4
3.0
ug/l
0.43
185
1739
531
5144
1.16
0.82
4.7
4.3
4.5
4.6
mmol/l
2.25
485
4723
153
1369
1.15
0.81
1.7
1.7
1.3
1.3
mmol/l
0.01
125
1142
34
264
1.30
0.73
1.4
1.3
—
—
—
0
0
5
25
2.01
0.73
1.6
1.2
—
—
—
0
0
5
25
2.01
0.73
3.0
1.5
—
—
—
0
0
5
25
2.01
0.73
1.6
1.2
—
—
—
0
0
5
26
1.93
0.70
3.0
1.5
—
—
—
0
0
539
5246
1.15
0.69
5.2
4.8
2.6
2.7
mmol/l
2.50
497
4797
12
77
1.57
0.69
1.9
1.7
—
—
—
0
0
5
27
1.86
0.68
1.4
1.8
1.2
10.7
u/field
—
5
18
7
43
1.63
0.67
1.3
1.2
—
—
—
0
0
7
43
1.63
0.67
1.3
1.2
—
—
—
0
0
5
28
1.79
0.66
1.4
1.3
—
—
—
0
0
5
28
1.79
0.66
1.4
1.3
—
—
—
0
0
12
78
1.55
0.66
7.0
4.5
384.0
360.0
umol/l
0.32
12
66
16
113
1.43
0.61
2.2
1.3
—
—
—
0
0
16
113
1.43
0.61
2.2
1.3
—
—
—
0
0
8
50
1.61
0.61
1.3
1.1
1.7
1.5
g/l
—
8
44
9
139
0.64
0.61
1.4
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
6
35
1.72
0.58
1.2
1.4
—
26.6
—
0
7
18
132
1.37
0.57
1.3
2.0
13.7
12.1
mg/l
0.39
18
120
19
141
1.36
0.57
1.3
1.3
—
—
—
0
0
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
11
156
0.70
0.50
1.8
1.5
—
—
—
0
0
7
46
1.53
0.48
2.0
2.5
—
—
—
0
0
7
48
1.46
0.47
1.0
1.1
—
—
—
0
0
7
50
1.40
0.45
1.0
1.1
—
—
—
0
0
18
139
1.30
0.44
1.2
1.3
—
—
—
0
0
5
32
1.57
0.42
3.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
6
43
1.40
0.35
3.3
2.2
664.7
578.2
ml
—
6
26
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
16
133
1.21
0.24
1.3
1.4
43.0
243.3
miu/ml
—
6
65
10
126
0.79
0.24
3.8
4.1
27.0
30.6
mg/l
—
5
91
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
164
1574
1.06
0.22
4.5
4.3
21.6
21.8
%
0.06
71
794
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
1.2
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
10
81
1.24
0.19
1.3
1.1
—
—
—
0
0
7
59
1.19
0.18
1.6
1.5
—
—
—
0
0
12
142
0.84
0.17
1.2
1.5
—
—
—
0
0
46
427
1.08
0.17
1.5
1.9
—
—
—
0
0
5
67
0.74
0.17
1.2
1.4
—
—
—
0
0
39
421
0.92
0.16
1.5
1.7
—
—
—
0
0
11
93
1.19
0.14
1.5
1.2
—
34.0
—
0
9
5
48
1.04
0.09
1.0
1.4
—
—
—
0
0
117
1143
1.03
0.08
3.4
3.0
0.6
0.7
ug/l
0.81
80
763
49
470
1.05
0.08
1.7
2.1
—
—
—
0
0
17
157
1.08
0.07
2.5
1.7
—
—
—
0
0
18
190
0.95
0.04
1.3
1.8
—
—
—
0
0
18
190
0.95
0.04
1.2
1.8
2.7
2.5
mg/l
0.06
11
138
10
95
1.05
0.00
3.3
1.9
211.1
227.1
pmol/l
—
10
88
10
96
1.04
0.00
2.2
1.6
—
—
—
0
0
14
136
1.03
0.00
2.7
2.4
16.8
94.1
ug/min
—
8
75
24
237
1.01
0.00
1.6
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_ACHAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ACHAL | 1.679 [1.43, 1.97] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.159 |
During the follow-up period (1.1.1998 — 31.12.2019), 400 out of 1422 females with K11_ACHAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ACHAL | 1.729 [1.48, 2.03] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 597 out of 1737 males with K11_ACHAL died.
Mortality risk
Mortality risk for people of age
years, who have K11_ACHAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.257% |
| 5 | 1.003% | 1.676% |
| 10 | 2.602% | 4.449% |
| 15 | 4.928% | 8.826% |
| 20 | 8.809% | 15.009% |
Relationships between endpoints
↥Index endpoint: K11_ACHAL – Achalasia of cardia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data