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Achalasia of cardia

DOID EFO Endpoint Browser PheWeb

K11_ACHAL

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K22.0
  • Hospital discharge: ICD-9 — 5300
  • Hospital discharge: ICD-8 — 5300
  • Cause of death: ICD-10 — K22.0
  • Cause of death: ICD-9 — 5300
  • Cause of death: ICD-8 — 5300

2 out of 7 registries used, show all original rules.

690

4. Check minimum number of events

None

690

5. Include endpoints

None

690

6. Filter based on genotype QC (FinnGen only)

670

Control definitions (FinnGen only)

Control exclude
K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K22
Name in latin
Achalasia cardiae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5195 2402 2748
Only index persons 4286 2011 2275
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.08
Only index persons 0.08 0.07 0.09
Median age at first event (years)
Whole population 56.29 57.84 54.84
Only index persons 53.34 54.74 52.09

-FinnGen-

Key figures

All Female Male
Number of individuals 670 329 341
Unadjusted period prevalence (%) 0.14 0.12 0.16
Median age at first event (years) 54.89 51.23 58.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
690
Matched controls
6900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
51.8
322.3
192
51
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
29.4
307.7
530
698
K22.0
ICD-10 Finland
Achalasia of cardia
+∞
307.7
568
*
R13
ICD-10 Finland
Dysphagia
19.6
266.5
239
182
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
105.6
235.9
122
14
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
26.5
211.0
154
74
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
343.6
204.0
197
8
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
70.2
186.0
102
17
UJD02
NOMESCO Finland
Gastroscopy
20.7
140.9
112
64
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
656.7
115.6
111
*
K22.2
ICD-10 Finland
Oesophageal obstruction
+∞
108.2
101
*
JCE21
NOMESCO Finland
Laparoscopic cardiomyotomy
+∞
98.3
92
*
A02BC05
ATC
esomeprazole; systemic
4.8
90.7
409
1614
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
9.9
89.6
112
133
K22.1
ICD-10 Finland
Ulcer of oesophagus
263.3
70.7
71
*
53009
ICD-8 Finland
Diseases of oesophagus, Functio laesa NUD
+∞
70.0
66
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
27.3
66.5
46
18
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
+∞
56.0
53
*
C08CA05
ATC
nifedipine; systemic
5.9
52.0
103
200
A02BC03
ATC
lansoprazole; oral
3.4
51.3
275
1124
UJC12
NOMESCO Finland
Flexible oesophagoscopy
99.5
50.6
55
6
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
512.4
49.0
48
*
A02BC02
ATC
pantoprazole; systemic
3.8
47.6
543
3415
A02BA02
ATC
ranitidine; systemic
3.5
45.2
199
711
A03FA02
ATC
cisapride; oral, rectal
5.4
45.0
96
199
53001
ICD-8 Finland
Diseases of oesophagus, Achalasia cardiae
+∞
44.2
42
*
K22.9
ICD-10 Finland
Disease of oesophagus, unspecified
223.2
41.3
42
*
A02BC04
ATC
rabeprazole; oral
4.8
39.2
96
223
A02BC01
ATC
omeprazole; systemic
2.9
36.5
245
1102
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
34.3
284
1417
K30
ICD-10 Finland
Functional dyspepsia
4.7
33.0
81
188
5300A
ICD-9 Finland
Diseases of oesophagus, Achalasia and cardiospasm
+∞
31.5
30
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
30.8
232
1093
K20
ICD-10 Finland
Oesophagitis
86.6
30.0
33
*
K22.7
ICD-10 Finland
Barrett oesophagus
69.1
29.2
33
5
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
10.8
28.2
31
30
T18.1
ICD-10 Finland
Foreign body in oesophagus
39.6
27.3
34
9
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
26.6
120
425
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
26.5
367
2249
WX402
NOMESCO Finland
General anaesthesia
2.6
25.2
184
843
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
93.6
24.8
27
*
UJF32
NOMESCO Finland
Coloscopy
2.5
24.7
208
1018
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
22.7
183
874
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.2
22.0
61
155
TJX90
NOMESCO Finland
Other minor procedure in gastroenterological surgery
226.9
21.7
22
*
XJC00
NOMESCO Finland
Oesophageal manometry
226.9
21.7
22
*
R12
ICD-10 Finland
Heartburn
3.9
21.5
68
190
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
21.1
169
801
1323
FHL
Esophagoscopy and dilatation
+∞
20.9
20
*
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
113.5
20.7
22
*
ZXC96
NOMESCO Finland
Robot assisted procedure
5.7
20.5
39
72
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
20.4
130
552
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
33.7
20.3
26
8
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.9
20.1
46
100
D21
ICPC
Swallowing problem
7.8
20.1
28
37
K22.8
ICD-10 Finland
Other specified diseases of oesophagus
205.7
19.7
20
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
19.1
322
2050
WX002
NOMESCO Finland
Sedation and analgesia
2.4
18.9
164
803
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
71.9
18.8
21
*
XJC10
NOMESCO Finland
Oesophageal pH monitoring
195.1
18.6
19
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
18.2
96
368
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
18.2
281
1725
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
18.1
148
704
JBW97
NOMESCO Finland
Other laparoscopic operation on diaphragm or laparoscopic or thoracoscopic operation for gastro-oesophageal reflux
+∞
17.8
17
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
17.6
110
460
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.0
17.5
27
40
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.4
17.3
144
689
A07AA02
ATC
nystatin; oral
3.7
17.3
57
164
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
16.9
177
932
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
+∞
16.7
16
*
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
+∞
16.7
16
*
K22.3
ICD-10 Finland
Perforation of oesophagus
+∞
16.7
16
*
ZXE00
NOMESCO Finland
One hour or less
2.0
16.7
292
1861
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
92.3
16.6
18
*
J01MA12
ATC
levofloxacin; systemic
2.3
16.6
151
750
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
16.5
209
1184
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
16.5
141
682
K29.3
ICD-10 Finland
Chronic superficial gastritis
30.9
16.2
21
7
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
4.3
16.0
42
102
JDB10
NOMESCO Finland
Percutaneous gastrostomy
12.1
15.7
28
24
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
14.2
15.6
26
19
K29.7
ICD-10 Finland
Gastritis, unspecified
14.2
15.6
26
19
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
15.4
210
1217
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.1
15.4
44
114
K59.09
ICD-10 Finland
Constipation, unspecified
3.2
15.2
63
210
Y0599
ICD-8 Finland
Investigation of digestive system
6.4
15.1
25
40
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
14.9
197
1128
R53
ICD-10 Finland
Malaise and fatigue
2.1
14.7
180
1001
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
14.3
67
240
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
13.7
56
185
53094
ICD-8 Finland
Diseases of oesophagus, Oesophagitis
+∞
13.6
13
*
R01AD08
ATC
fluticasone; nasal
2.0
13.2
192
1131
R4110
NOMESCO Finland
Physiotherapy
1.9
13.1
202
1212
R4190
NOMESCO Finland
Nutritional therapy
4.0
13.0
37
96
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
12.9
74
295
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
5.3
12.8
26
51
J01MA02
ATC
ciprofloxacin; systemic
1.8
12.7
277
1856
6241
FHL
Fund application (Nissen)
+∞
12.5
12
*
K29.1
ICD-10 Finland
Other acute gastritis
24.8
12.5
17
7
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
12.5
157
876
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
12.1
85
374
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
12.0
271
1825
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
11.8
178
1055
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
11.8
108
533
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
16.8
11.7
18
11
A01AB04
ATC
amphotericin B; local oral
3.4
11.5
42
129
R42
ICD-10 Finland
Dizziness and giddiness
1.9
11.5
168
985
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
11.5
69
282
R03BA05
ATC
fluticasone; inhalant
2.1
11.4
123
648
A01AB09
ATC
miconazole; local oral
2.6
11.4
68
277
JN4BD
NOMESCO Finland
Extensive body CT
2.3
11.3
88
405
ZXD05
NOMESCO Finland
Urgent procedure
1.8
11.3
216
1380
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
11.2
136
747
N03AX16
ATC
[U] pregabalin
1.9
11.2
160
931
A02BA03
ATC
famotidine; systemic
4.1
11.1
31
79
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
11.0
176
1063
1310
FHL
Esophagogastroscopy
44.1
10.9
13
*
Z3226
NOMESCO Finland
Physiotherapist
2.0
10.9
134
740
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
10.8
338
2476
N06AX11
ATC
mirtazapine; oral
1.8
10.8
223
1455
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
10.8
50
178
N06AA09
ATC
amitriptyline; systemic
2.5
10.7
68
285
A02BA04
ATC
nizatidine; systemic
2.7
10.5
58
227
R11
ICD-10 Finland
Nausea and vomiting
2.5
10.5
67
282
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
+∞
10.4
10
*
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
+∞
10.4
10
*
5308A
ICD-9 Finland
Diseases of oesophagus, Other specified disorders of oesophagus[HERNIA HIATUS OESOPHAGI (""""SLIDING HERNIA"""")]
+∞
10.4
10
*
C01DA14
ATC
isosorbide mononitrate; oral
2.0
10.4
128
705
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
10.4
125
684
K59.1
ICD-10 Finland
Functional diarrhoea
3.2
10.3
41
133
R06AE07
ATC
cetirizine; oral
1.7
10.3
274
1913
H02AB06
ATC
prednisolone; systemic
1.7
10.2
316
2298
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
10.1
150
881
N05AH04
ATC
quetiapine; oral
2.0
10.1
120
653
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
10.1
104
537
L28
ICPC
Limited function/disability (L)
2.0
10.0
125
693
Z3231
NOMESCO Finland
Registered nurse
1.8
9.9
190
1207
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
9.9
56
222
H02AB09
ATC
hydrocortisone; systemic
4.5
9.9
24
55
J02AC01
ATC
fluconazole; systemic
1.7
9.7
231
1560
R03AC02
ATC
salbutamol; inhalant
1.7
9.7
353
2667
C07AB02
ATC
metoprolol; systemic
1.9
9.7
149
884
J46
ICD-10 Finland
Status asthmaticus
4.4
9.7
24
56
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
9.6
134
770
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.7
9.6
22
48
K92.0
ICD-10 Finland
Haematemesis
7.3
9.6
22
31
C03CA01
ATC
furosemide; systemic
1.7
9.6
220
1471
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
9.5
65
282
R02
ICPC
Shortness of breath/dyspnoea
2.1
9.5
95
485
K92.1
ICD-10 Finland
Melaena
3.1
9.5
40
135
K29.6
ICD-10 Finland
Other gastritis
101.4
9.4
10
*
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
101.4
9.4
10
*
D84
ICPC
Oesophagus disease
30.5
9.4
12
*
K29.4
ICD-10 Finland
Chronic atrophic gastritis
22.0
9.4
13
6
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
9.4
105
559
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
9.3
135
784
UKC02
NOMESCO Finland
Cystoscopy
1.9
9.3
122
685
WX110
NOMESCO Finland
Infiltration anesthesia
1.7
9.3
456
3701
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
9.3
114
626
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
9.1
230
1572
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.1
295
2151
A02BX02
ATC
sucralfate; oral
3.4
9.1
32
96
UJF92
NOMESCO Finland
Capsular endoscopy
7.2
9.1
21
30
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.7
9.1
28
77
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
9.1
36
117
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.4
9.0
63
277
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
8.9
53
215
N05CF01
ATC
zopiclone; oral
1.7
8.9
216
1460
Z2221
NOMESCO Finland
Medical doctor
1.7
8.8
185
1201
M79.6
ICD-10 Finland
Pain in limb
1.6
8.8
267
1912
K29.9
ICD-10 Finland
Gastroduodenitis, unspecified
50.6
8.7
10
*
G47.3
ICD-10 Finland
Sleep apnoea
1.8
8.7
148
904
R01AD09
ATC
mometasone; nasal
1.6
8.6
280
2038
N03AE01
ATC
clonazepam; systemic
2.8
8.6
42
154
A06AD11
ATC
lactulose; oral
1.9
8.6
111
620
WZC30
NOMESCO Finland
Teaching
1.9
8.5
111
622
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
8.5
56
239
XF402
NOMESCO Finland
ECG with work load test
2.2
8.4
74
358
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.8
8.4
41
150
J01DB01
ATC
cefalexin; oral
1.8
8.4
543
4671
A01
ICPC
Pain general/multiple sites
2.3
8.4
64
292
JCA96
NOMESCO Finland
Other local operation on oesophagus
+∞
8.3
8
*
6302
FHL
Esophagogastromyotomy (Heller)
+∞
8.3
8
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.2
180
1179
UJC02
NOMESCO Finland
Rigid oesophagoscopy
14.7
8.2
13
9
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
4.4
8.0
20
47
R03DC03
ATC
montelukast; oral
1.9
7.9
101
561
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
7.9
39
144
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
7.9
55
241
N02BE01
ATC
paracetamol; systemic, rectal
1.9
7.8
590
5237
G04BD08
ATC
solifenacin; oral
2.4
7.8
52
224
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
7.7
106
603
R60.0
ICD-10 Finland
Localized oedema
2.0
7.7
84
441
D03
ICPC
Heartburn
3.4
7.7
27
81
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.7
78
399
R07.0
ICD-10 Finland
Pain in throat
2.7
7.7
42
164
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.6
7.7
44
176
D06
ICPC
Abdominal pain localized other
2.3
7.6
58
265
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
7.6
69
339
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
7.5
110
639
M01AB55
ATC
diclofenac, combinations; oral
2.5
7.4
48
203
A28
ICPC
Limited function/disability NOS
1.8
7.4
120
719
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
80.9
7.4
8
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.7
7.4
40
155
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
7.4
160
1043
J01FA09
ATC
clarithromycin; systemic
1.6
7.3
189
1288
R01AD12
ATC
fluticasone furoate; nasal
1.7
7.3
181
1220
N06AX21
ATC
duloxetine; oral
2.1
7.3
72
364
N05BA01
ATC
diazepam; systemic, rectal
2.0
7.3
89
486
A06AC51
ATC
ispaghula, combinations; oral
2.8
7.3
35
127
R49.01
ICD-10 Finland
Functional dysphonia
3.6
7.3
24
69
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.5
7.3
44
180
K22
ICD-10 Finland
Other diseases of oesophagus
+∞
7.3
7
*
JCA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in oesophagus
+∞
7.3
7
*
JCE20
NOMESCO Finland
Cardiomyotomy
+∞
7.3
7
*
R03AC03
ATC
terbutaline; inhalant
1.9
7.2
89
488
P01AB01
ATC
metronidazole; oral, rectal
1.6
7.2
244
1774
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
7.2
111
656
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
7.2
59
278
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
7.2
173
1159
R03BA01
ATC
beclometasone; inhalant
1.9
7.1
93
521
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
7.1
272
2034
J01MA14
ATC
moxifloxacin; systemic
2.1
7.1
65
320
JN4AD
NOMESCO Finland
Body CT examination
2.1
7.0
72
370
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.9
105
616
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
6.9
111
663
49300
ICD-8 Finland
Asthma, bronchiale
3.6
6.9
22
62
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
6.9
258
1917
R07.3
ICD-10 Finland
Other chest pain
2.1
6.9
66
331
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.9
6.9
31
109
J01DA01
ATC
[U] cefalexin
1.5
6.9
401
3279
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.5
6.8
44
186
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.1
6.8
65
325
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.0
6.8
30
104
D02
ICPC
Abdominal pain epigastric
2.6
6.8
38
150
R63.4
ICD-10 Finland
Abnormal weight loss
3.0
6.8
29
99
Z01.9
ICD-10 Finland
Special examination, unspecified
2.4
6.8
47
206
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.3
6.8
49
219
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.7
212
1512
D10
ICPC
Vomiting
2.7
6.7
35
133
SPAT1104
SPAT
Monitoring of emergency patient
2.4
6.7
46
200
J01FA10
ATC
azithromycin; systemic
1.5
6.7
344
2732
M54.5
ICD-10 Finland
Low back pain
1.6
6.7
218
1568
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
3.9
6.6
19
50
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
6.6
31
112
R05
ICD-10 Finland
Cough
1.7
6.6
129
817
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
6.9
6.5
15
22
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
6.5
139
899
R52.0
ICD-10 Finland
Acute pain
3.1
6.5
26
85
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
5.8
6.5
17
30
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.5
6.5
22
65
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
6.5
38
154
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.5
202
1437
N05BA04
ATC
oxazepam; oral
1.6
6.4
161
1085
M54.8
ICD-10 Finland
Other dorsalgia
2.9
6.4
29
102
JCE96
NOMESCO Finland
Other reconstruction of oesophagus
70.5
6.4
7
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
6.4
69
361
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
6.4
74
397
Z71.8
ICD-10 Finland
Other specified counselling
1.6
6.4
188
1318
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
6.4
91
524
P25
ICPC
Phase of life problem adult
3.2
6.4
25
81
R03BB04
ATC
tiotropium bromide; inhalant
2.0
6.3
74
399
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
6.3
122
768
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
6.3
120
754
R03AK08
ATC
formoterol and beclometasone; inhalant
2.8
6.3
31
115
K31.8
ICD-10 Finland
Other specified diseases of stomach and duodenum
+∞
6.3
6
*
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
+∞
6.3
6
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
6.2
235
1740
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.6
6.2
34
133
J01CA04
ATC
amoxicillin; systemic
1.6
6.2
518
4526
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
6.2
75
409
R51.81
ICD-10 Finland
Facial pain NOS
3.6
6.2
20
57
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
6.2
100
598
E86
ICD-10 Finland
Volume depletion
3.5
6.2
21
62
N03AX12
ATC
[U] gabapentin; oral
1.8
6.2
103
622
S06.0
ICD-10 Finland
Concussion
2.0
6.2
72
388
J01FF01
ATC
clindamycin; systemic
1.6
6.2
169
1164
J37.0
ICD-10 Finland
Chronic laryngitis
3.1
6.1
25
83
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.8
6.1
29
105
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
6.1
52
249

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
267
446
9.13
166.97
1.7
1.2
—
—
—
0
0
427
2562
2.75
35.94
18.6
16.5
1.26
1.31
inr
0.48
127
761
374
2271
2.41
28.14
4.8
4.5
35.15
35.34
g/l
0.28
356
2117
459
3160
2.35
24.39
7.2
4.5
6.37
6.68
mmol/l
2.83
446
2956
292
1688
2.27
23.43
3.4
2.3
—
—
—
0
0
231
1261
2.25
20.81
2.9
2.2
—
—
—
0
0
388
2638
2.08
19.31
6.1
5.8
0.21
0.19
e9/l
1.50
354
2323
259
1526
2.12
18.88
3.7
2.2
61.83
60.26
u/l
0.15
248
1416
376
2542
2.05
18.83
6.0
5.5
0.60
0.59
e9/l
0.45
342
2211
376
2550
2.04
18.58
6.0
5.5
0.04
0.04
e9/l
0.69
343
2224
526
4080
2.22
17.59
8.8
7.2
78.43
78.51
u/l
0.01
508
3820
380
2624
2.00
17.43
6.0
5.6
2.09
1.94
e9/l
0.33
350
2331
367
2512
1.98
17.18
3.1
2.5
—
—
—
0
0
353
2385
1.98
17.15
5.9
5.6
3.08
2.78
%
1.40
337
2244
355
2405
1.98
17.09
6.5
6.0
—
—
—
0
0
354
2402
1.97
16.90
6.2
5.9
8.56
8.73
%
0.43
338
2261
109
463
2.61
16.89
9.1
6.7
1.45
1.33
mmol/l
0.35
109
453
386
2702
1.97
16.78
7.2
6.1
11.57
11.58
umol/l
0.00
370
2570
359
2458
1.96
16.59
6.0
5.7
26.68
27.20
%
0.35
343
2322
340
2303
1.94
16.04
6.0
5.7
0.68
0.65
%
0.34
325
2159
351
2411
1.93
15.80
5.8
5.5
58.24
57.96
%
0.15
335
2280
108
476
2.50
15.44
2.2
1.9
0.20
0.21
g/l
0.97
103
445
222
1313
2.02
15.43
5.0
3.6
84.40
89.02
%
1.85
216
1283
308
2057
1.90
14.81
5.3
3.5
51.43
46.57
ng/l
0.07
232
1478
244
1519
1.94
14.45
5.5
4.1
—
—
—
0
0
215
1292
1.96
14.06
2.8
2.0
3.01
3.09
mg/l
0.22
190
1092
370
2672
1.83
13.44
8.5
6.6
1.21
1.21
mmol/l
1.42
320
2260
495
3926
1.92
13.18
4.8
3.8
13.78
12.63
mm/h
0.85
454
3593
341
2418
1.81
13.01
7.7
6.0
1.20
1.21
mmol/l
2.18
312
2193
403
3008
1.82
12.92
9.2
9.2
4.23
4.18
e9/l
0.14
366
2626
154
853
2.04
12.52
3.6
3.3
0.81
0.82
mmol/l
0.36
148
801
117
596
2.16
11.82
9.9
7.2
5.05
5.10
kpa
0.18
112
574
298
2084
1.76
11.48
2.3
2.2
79.51
77.46
nmol/l
0.48
265
1853
29
69
4.34
11.37
3.2
2.8
—
—
—
0
0
116
599
2.13
11.29
9.6
7.2
1.34
1.34
mmol/l
0.01
99
478
439
3458
1.74
10.77
3.7
2.8
53.55
46.69
u/l
0.68
411
3230
89
423
2.27
10.62
10.8
8.5
—
—
—
0
0
126
691
2.01
10.38
4.6
5.7
1.01
1.03
mmol/l
0.44
118
629
20
38
5.39
10.16
1.3
1.4
6.02
6.76
g/l
—
10
26
20
38
5.39
10.16
1.3
1.4
0.26
0.29
g/l
—
10
26
20
38
5.39
10.16
1.3
1.4
2.72
2.59
g/l
—
10
25
305
2206
1.69
10.00
3.2
2.7
117.99
137.09
ug/l
0.87
281
2018
20
39
5.25
9.89
1.3
1.4
—
—
—
0
0
180
1141
1.78
9.40
1.8
1.7
0.91
1.17
mg/l
1.53
150
883
163
1008
1.81
9.23
2.0
1.7
1092.07
1207.54
nmol/l
0.89
123
758
295
2149
1.65
9.19
2.3
1.9
90.24
94.03
pmol/l
0.79
161
1096
121
686
1.93
8.99
2.3
2.5
19.38
22.86
%
2.28
111
586
140
833
1.85
8.97
2.1
2.1
30.13
29.70
s
0.43
135
807
194
1278
1.72
8.78
6.5
7.1
—
—
—
0
0
70
326
2.28
8.74
4.1
3.7
7.42
7.40
ph
0.68
11
45
235
1635
1.66
8.64
2.6
2.0
171.71
228.50
u/l
0.97
220
1540
228
1576
1.67
8.59
4.6
3.7
—
—
—
0
0
25
66
3.89
8.58
2.5
3.2
—
—
—
0
0
234
1631
1.66
8.52
3.7
3.0
1230.14
1574.09
ng/l
0.98
207
1405
315
2371
1.60
8.36
13.3
9.6
0.00
0.00
e9/l
0.61
274
1974
605
5389
2.00
8.28
24.4
13.8
24.32
25.02
mg/l
0.22
534
4222
285
2100
1.61
8.23
2.0
2.1
—
—
—
0
0
480
4021
1.64
7.96
4.6
3.8
15.01
14.86
pmol/l
0.61
433
3627
619
5576
2.07
7.93
27.1
16.1
139.48
139.67
mmol/l
1.13
608
5418
432
3531
1.60
7.90
5.8
4.4
41.00
2042.37
e6/l
—
6
73
123
735
1.82
7.70
2.3
2.4
2.37
2.29
g/l
0.86
115
683
619
5590
2.04
7.65
27.1
16.2
3.96
3.99
mmol/l
1.12
607
5427
35
125
2.90
7.53
1.5
1.4
262.12
296.83
ug/g
0.43
20
67
443
3683
1.57
7.18
5.5
4.1
—
—
—
0
0
129
799
1.76
7.13
2.4
2.4
11.79
12.84
umol/l
0.74
123
740
59
279
2.22
7.12
8.1
9.8
—
—
—
0
0
458
3849
1.56
6.97
4.9
3.8
—
—
—
0
0
215
1532
1.59
6.89
3.7
3.0
0.51
0.55
e6/l
0.10
182
1185
35
132
2.74
6.84
3.9
4.2
7.41
7.42
ph
0.31
28
117
94
538
1.87
6.72
1.7
2.0
218.80
117.91
ug/g
1.12
79
429
167
1126
1.64
6.70
3.5
2.8
522.27
555.33
mosm/kgh2o
1.01
143
984
174
1186
1.62
6.68
3.2
2.5
5.28
5.55
e6/l
0.10
156
1079
207
1471
1.58
6.68
3.6
3.0
—
—
—
0
0
152
1010
1.65
6.44
4.3
3.7
1980.61
271.85
ng/l
0.51
120
812
142
928
1.67
6.41
1.7
1.4
2.24
2.55
g/l
1.12
90
583
93
539
1.84
6.39
2.6
2.4
7.53
8.93
umol/l
0.49
75
467
23
71
3.32
6.33
1.2
1.4
0.41
0.69
g/l
0.97
11
53
244
1825
1.52
6.17
2.7
3.4
2.33
2.35
mmol/l
1.17
215
1613
50
235
2.22
6.14
4.2
3.8
—
—
—
0
0
25
84
3.05
6.01
1.8
1.3
—
—
—
0
0
99
596
1.77
5.99
2.3
2.6
1.75
1.75
%
0.02
88
540
227
1682
1.52
5.96
3.9
3.2
65.45
66.67
e6/l
0.02
189
1324
256
1947
1.50
5.93
4.4
3.6
104.98
139.65
e6/l
0.29
204
1424
28
102
2.82
5.86
2.6
2.3
127.68
128.01
g/l
0.02
22
81
71
389
1.92
5.80
3.0
3.0
9.74
10.40
g/l
0.72
66
357
627
5786
1.92
5.80
13.3
9.8
26.72
25.92
u/l
0.46
610
5567
28
103
2.79
5.76
3.6
4.1
—
—
—
0
0
51
249
2.13
5.71
1.3
1.2
—
—
—
0
0
220
1634
1.51
5.66
3.5
3.1
—
—
—
0
0
45
211
2.21
5.57
1.9
1.7
—
—
—
0
0
149
1029
1.57
5.30
1.3
1.2
0.81
1.58
u/ml
1.58
42
270
188
1370
1.51
5.24
2.7
2.8
346.58
7092.18
umol/l
5.22
161
1201
84
504
1.76
5.14
1.5
1.4
—
—
—
0
0
216
1627
1.48
5.10
4.4
4.2
7.40
7.40
ph
0.30
46
321
116
768
1.61
4.91
1.9
2.0
—
—
—
0
0
98
624
1.66
4.84
2.0
1.6
—
—
—
0
0
80
486
1.73
4.69
3.7
3.6
3.11
1.97
mmol/l
2.26
67
396
77
463
1.75
4.68
2.5
2.3
3.77
7.63
ug/l
3.11
61
403
543
4899
1.51
4.64
5.6
4.5
1.86
2.17
mu/l
0.65
503
4455
69
403
1.79
4.63
3.7
4.2
0.00
0.10
%
0.91
16
126
75
449
1.75
4.63
3.8
4.2
1.23
0.92
%
0.40
22
172
609
5642
1.68
4.60
22.1
13.0
—
—
—
0
0
51
272
1.94
4.54
1.3
1.2
—
—
—
0
0
173
1274
1.48
4.50
1.7
1.5
19.57
20.53
nmol/l
0.39
154
1069
51
273
1.94
4.49
2.8
3.7
4.45
4.50
pmol/l
0.11
41
240
317
2613
1.39
4.41
5.0
3.6
0.00
0.00
estimate
-0.00
81
553
320
2642
1.39
4.40
5.0
3.6
0.00
0.00
estimate
-0.00
78
502
71
426
1.74
4.36
3.8
4.3
0.28
0.11
%
0.63
18
148
24
95
2.58
4.34
2.7
2.6
3.54
4.37
e9/l
1.72
24
95
75
458
1.72
4.33
3.6
2.3
42.76
31.13
u/l
1.30
66
389
69
413
1.75
4.27
3.4
2.6
4.17
4.36
kpa
0.44
69
398
29
127
2.34
4.25
3.8
3.0
0.77
0.86
nmol/l
0.52
19
109
316
2616
1.38
4.22
6.8
4.8
0.00
0.00
estimate
0.50
77
517
27
115
2.40
4.21
3.8
2.6
16.21
15.86
%
0.13
17
58
18
62
2.95
4.20
1.5
1.5
—
—
—
0
0
79
494
1.68
4.18
3.7
3.6
5.99
5.82
kpa
0.73
79
480
156
1142
1.47
4.16
1.7
1.7
488.14
6122874.52
pmol/l
0.50
122
931
26
110
2.42
4.11
4.2
4.5
2.56
2.87
mmol/l
0.20
21
75
32
150
2.19
4.02
3.4
3.2
—
—
—
0
0
67
405
1.72
4.02
3.6
4.2
0.83
0.58
%
0.38
18
144
121
850
1.51
3.93
1.3
1.2
20.79
38.09
iu/ml
1.92
50
266
518
4682
1.43
3.93
25.8
16.8
15.22
14.86
%
0.70
512
4603
74
463
1.67
3.92
2.9
2.9
210.72
223.56
ng/l
0.09
67
426
638
6032
1.77
3.86
33.4
20.2
250.13
245.78
e9/l
0.92
627
5867
24
101
2.43
3.85
2.7
2.9
54.50
58.13
%
0.74
24
101
638
6035
1.76
3.81
33.2
20.2
91.15
91.19
fl
0.07
630
5939
211
1656
1.39
3.80
3.7
3.7
5.35
10.33
mg/mmol
2.19
122
1038
71
443
1.67
3.80
2.9
2.7
66.49
67.17
e9/l
0.05
56
345
638
6036
1.76
3.79
33.2
20.1
30.15
30.37
pg
2.00
630
5939
29
134
2.22
3.78
2.6
2.2
1.96
1865.68
u/l
—
5
54
638
6037
1.75
3.77
33.3
20.2
4.41
4.49
e12/l
3.52
624
5855
82
532
1.61
3.77
3.1
4.6
3.42
18.33
ug/l
1.19
64
449
77
492
1.64
3.76
4.4
4.4
—
—
—
0
0
638
6038
1.75
3.76
33.4
20.3
6.98
6.75
e9/l
1.09
625
5856
61
367
1.73
3.73
3.1
3.0
—
—
—
0
0
638
6040
1.75
3.73
33.6
20.4
132.29
135.73
g/l
6.54
629
5938
44
240
1.89
3.70
3.7
4.3
25.24
24.21
mmol/l
1.31
44
234
56
330
1.76
3.68
2.4
2.7
11.42
8.33
e9/l
0.24
45
268
637
6032
1.73
3.66
34.0
20.3
39.46
40.20
%
2.08
612
5628
73
464
1.64
3.65
4.5
4.0
1.21
1.23
mmol/l
0.86
65
400
95
645
1.55
3.61
1.5
1.3
484.14
452.33
titre
0.06
29
133
210
1660
1.38
3.60
3.4
3.0
7.42
7.60
mmol/l
0.24
177
1392
36
185
2.00
3.60
1.4
1.2
0.18
2.00
u/ml
—
5
14
43
236
1.88
3.56
1.6
2.1
1.61
1.57
g/l
0.09
35
207
74
476
1.62
3.53
1.3
1.4
—
—
—
0
0
73
470
1.62
3.47
5.2
3.6
—
—
—
0
0
38
203
1.92
3.41
7.3
4.0
—
—
—
0
0
30
147
2.09
3.41
2.9
2.7
1.45
1.65
mg/l
0.78
25
133
90
616
1.53
3.30
1.5
1.4
—
—
—
0
0
15
54
2.82
3.27
1.3
1.2
—
—
—
0
0
63
401
1.63
3.15
2.5
2.1
13.42
12.82
nmol/l
0.23
52
364
118
864
1.44
3.11
3.1
2.9
2.36
1.54
e6/l
0.72
68
491
19
80
2.41
3.08
1.5
1.8
—
—
—
0
0
8
16
5.04
3.05
1.3
1.0
—
—
—
0
0
8
16
5.04
3.05
1.3
1.0
—
—
—
0
0
8
16
5.04
3.05
1.3
1.0
—
—
—
0
0
196
1568
1.35
3.05
3.3
3.1
347.42
233.59
mg/l
0.14
120
1008
7
12
5.88
3.02
2.6
1.4
—
—
—
0
0
27
134
2.06
3.00
4.9
4.9
—
—
—
0
0
543
5027
1.38
2.96
6.3
5.6
39.73
39.78
mmol/mol
0.04
506
4656
15
58
2.62
2.89
1.0
1.3
—
—
—
0
0
9
22
4.13
2.89
2.6
2.0
—
—
—
0
0
182
1452
1.34
2.86
5.3
3.9
0.00
0.00
estimate
0.50
75
491
58
371
1.62
2.86
1.5
1.4
—
—
—
0
0
249
2081
1.31
2.82
4.4
3.3
6.39
5.82
ph
—
9
154
95
681
1.46
2.80
1.3
1.3
—
—
—
0
0
21
98
2.18
2.73
3.2
2.9
—
—
—
0
0
550
5123
1.36
2.72
4.2
3.8
1.31
1.26
mmol/l
0.78
500
4648
12
44
2.76
2.55
1.4
1.3
—
—
—
0
0
34
195
1.78
2.51
6.7
3.6
1.72
1.31
mmol/l
0.37
34
190
14
57
2.49
2.46
1.6
1.4
—
—
—
0
0
562
5285
1.34
2.35
5.1
4.4
5.87
5.95
mmol/l
0.87
512
4782
12
47
2.58
2.28
3.0
1.1
—
—
—
0
0
6
13
4.65
2.27
1.0
1.1
—
—
—
0
0
58
396
1.51
2.20
3.0
3.9
73.48
90.61
ng/l
1.46
47
337
107
819
1.36
2.19
1.6
1.8
—
—
—
0
0
179
1477
1.29
2.16
4.5
3.3
—
—
—
0
0
16
74
2.19
2.16
1.5
1.1
2.86
6.88
u/ml
—
7
25
11
42
2.64
2.15
1.1
1.1
—
—
—
0
0
10
36
2.80
2.14
1.3
1.1
—
—
—
0
0
8
25
3.23
2.10
1.8
1.3
—
—
—
0
0
62
435
1.47
2.07
4.0
3.4
—
—
—
0
0
18
89
2.05
2.07
1.8
3.2
—
—
—
0
0
5
10
5.03
2.07
1.2
1.5
94.40
86.10
nmol/24h
—
5
10
7
20
3.52
2.06
1.1
1.0
—
—
—
0
0
13
56
2.35
2.06
2.6
3.5
—
—
—
0
0
6
15
4.03
2.04
1.0
1.1
—
—
—
0
0
17
83
2.07
2.02
3.4
1.4
—
—
—
0
0
19
97
1.99
2.02
1.2
1.3
—
—
—
0
0
52
355
1.50
1.99
5.2
4.2
—
—
—
0
0
15
70
2.17
1.99
2.8
2.0
87.56
89.33
%
0.35
15
70
13
57
2.31
1.98
1.5
1.3
—
—
—
0
0
26
149
1.77
1.97
4.3
1.5
—
—
—
0
0
10
39
2.59
1.94
2.5
3.7
—
—
—
0
0
5
11
4.57
1.94
1.0
1.0
—
—
—
0
0
143
1163
1.29
1.92
4.8
3.6
—
—
—
0
0
141
1150
1.28
1.86
5.6
4.0
1.02
1.02
kg/l
0.21
27
147
27
160
1.72
1.84
4.1
1.5
—
—
—
0
0
27
160
1.72
1.84
4.1
1.5
—
—
—
0
0
24
138
1.77
1.81
1.0
1.2
—
—
—
0
0
12
53
2.29
1.81
3.0
1.1
—
—
—
0
0
27
161
1.70
1.81
4.1
1.4
—
—
—
0
0
7
23
3.06
1.80
1.1
1.0
—
—
—
0
0
38
248
1.56
1.80
2.1
2.4
—
—
—
0
0
20
109
1.86
1.79
1.2
1.3
137.14
1091.61
e6/l
0.49
14
92
20
109
1.86
1.79
1.2
1.3
2.92
87.73
e6/l
0.95
13
88
13
60
2.19
1.78
1.7
1.3
1580.14
1704.13
e6/l
—
7
38
128
1038
1.29
1.76
2.5
3.2
2.44
2.45
mmol/l
1.05
115
929
12
54
2.24
1.74
1.8
1.3
149950.00
26213.14
e6/l
—
6
28
102
808
1.31
1.68
1.4
1.2
29.96
12.94
u/ml
0.75
34
297
10
42
2.40
1.62
1.0
1.1
—
—
—
0
0
21
121
1.76
1.60
1.5
1.2
30.88
11.90
u/ml
—
6
20
44
306
1.47
1.58
1.3
1.2
91.39
143.77
iu/ml
0.37
16
128
26
160
1.65
1.58
4.2
1.5
—
—
—
0
0
71
539
1.35
1.57
1.3
1.2
—
—
—
0
0
22
130
1.72
1.54
2.1
1.6
—
—
—
0
0
16
87
1.86
1.47
1.2
1.4
—
—
—
0
0
28
181
1.57
1.42
4.9
4.6
23.87
30.98
mg/l
1.03
18
146
28
181
1.57
1.42
4.9
4.6
31.94
59.90
mg/l
1.76
18
144
15
81
1.87
1.41
1.0
1.1
259.29
278.27
u/ml
—
7
48
9
41
2.21
1.37
1.0
1.3
—
—
—
0
0
23
143
1.63
1.37
1.3
1.2
—
—
—
0
0
556
5323
1.23
1.35
4.7
4.2
1.43
1.45
mmol/l
0.41
507
4868
167
1442
1.21
1.32
1.5
1.4
—
—
—
0
0
49
363
1.38
1.29
1.2
1.1
—
—
—
0
0
9
44
2.06
1.27
2.9
1.4
—
—
—
0
0
9
44
2.06
1.27
2.0
2.5
—
—
—
0
0
13
70
1.87
1.24
2.6
2.1
30.62
32.23
pg
0.56
13
70
69
542
1.30
1.24
1.5
1.6
—
—
—
0
0
20
124
1.63
1.22
5.3
1.7
—
—
—
0
0
14
78
1.81
1.22
1.6
2.3
—
—
—
0
0
5
19
2.64
1.22
1.0
4.3
11.24
19.69
mu/l
—
5
19
13
71
1.85
1.20
7.5
1.9
—
—
—
0
0
558
5364
1.21
1.19
4.7
4.3
4.45
4.61
mmol/l
2.93
509
4934
12
64
1.89
1.18
1.0
1.0
2.37
6.51
u/ml
—
5
33
13
72
1.82
1.15
1.2
1.1
15.64
1.99
u/ml
—
7
40
20
126
1.60
1.15
1.9
1.8
—
—
—
0
0
8
39
2.06
1.15
1.3
1.1
—
—
—
0
0
5
20
2.51
1.15
1.6
2.1
—
—
—
0
0
18
111
1.64
1.13
2.1
1.7
445.19
6.57
iu/l
—
7
33
17
104
1.65
1.10
6.6
1.7
—
—
—
0
0
5
21
2.39
1.09
1.4
3.4
742.20
897.76
u/ml
—
5
21
24
162
1.50
1.05
1.2
1.1
—
—
—
0
0
13
75
1.75
1.03
1.0
1.1
—
—
—
0
0
10
53
1.90
1.01
1.0
1.2
—
—
—
0
0
566
5470
1.19
1.01
5.2
4.8
2.59
2.73
mmol/l
3.39
520
5013
5
23
2.18
0.98
1.0
1.3
115.60
152.76
nmol/l
—
5
23
5
23
2.18
0.98
1.0
1.2
—
—
—
0
0
9
50
1.81
0.97
1.3
1.1
—
—
—
0
0
9
52
1.74
0.92
2.0
1.3
—
—
—
0
0
222
2023
1.14
0.89
5.2
4.9
2.34
3.43
ug/l
0.78
193
1810
6
29
2.08
0.89
2.2
4.0
—
—
—
0
0
161
1434
1.16
0.89
1.7
1.7
1.42
1.35
mmol/l
0.29
131
1200
19
129
1.49
0.84
1.2
1.1
—
—
—
0
0
6
32
1.88
0.82
2.5
2.3
482.00
493.67
min
—
6
21
6
32
1.88
0.82
1.5
1.3
—
—
—
0
0
6
33
1.83
0.79
1.2
1.8
—
—
—
0
0
13
82
1.60
0.78
2.2
2.5
—
—
—
0
0
9
53
1.71
0.75
1.1
1.0
—
—
—
0
0
12
75
1.61
0.75
1.1
1.5
—
—
—
0
0
11
172
0.63
0.74
12.9
10.6
—
—
—
0
0
8
132
0.60
0.74
1.6
1.3
—
—
—
0
0
7
38
1.85
0.73
1.0
1.0
—
—
—
0
0
30
388
0.76
0.72
1.4
1.7
—
—
—
0
0
17
118
1.45
0.70
2.3
2.2
—
—
—
0
0
44
356
1.25
0.69
1.2
1.4
—
—
—
0
0
41
330
1.26
0.68
3.8
3.1
—
—
—
0
0
5
28
1.79
0.66
1.4
1.8
1.20
10.17
u/field
—
5
19
12
78
1.55
0.66
7.0
4.4
384.00
357.82
umol/l
0.36
12
66
10
62
1.62
0.65
1.6
2.4
—
—
—
0
0
77
665
1.18
0.65
1.5
1.6
—
—
—
0
0
5
29
1.73
0.64
1.4
1.4
—
—
—
0
0
13
87
1.50
0.63
1.2
1.2
—
—
—
0
0
8
51
1.58
0.60
3.3
2.6
—
—
—
0
0
8
51
1.58
0.60
1.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
164.89
—
0
23
29
230
1.27
0.56
1.2
1.2
—
—
—
0
0
40
481
0.82
0.56
1.4
1.3
—
—
—
0
0
31
249
1.26
0.54
1.5
1.7
—
—
—
0
0
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
29
232
1.26
0.53
2.8
3.0
—
—
—
0
0
16
117
1.38
0.52
1.8
2.7
—
—
—
0
0
6
40
1.50
0.51
1.8
2.1
30.25
35.06
%
—
6
40
7
110
0.63
0.48
2.0
1.6
—
—
—
0
0
24
190
1.27
0.48
2.9
3.4
0.49
0.25
g/l
—
9
82
18
138
1.31
0.46
1.3
2.0
13.69
12.06
mg/l
0.40
18
127
7
51
1.38
0.44
1.4
1.3
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
175.00
170.19
pmol/l
—
5
31
10
71
1.41
0.39
1.1
1.0
—
13.38
—
0
6
9
67
1.35
0.38
3.1
3.9
—
—
—
0
0
5
37
1.35
0.37
1.8
3.5
—
—
—
0
0
12
90
1.34
0.36
2.3
1.3
—
—
—
0
0
19
153
1.25
0.35
6.0
4.9
—
—
—
0
0
51
452
1.14
0.35
1.5
1.3
—
—
—
0
0
6
44
1.37
0.34
3.3
2.1
664.67
575.63
ml
—
6
27
50
560
0.88
0.33
1.9
1.6
—
—
—
0
0
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
11
83
1.33
0.32
1.0
1.7
—
—
—
0
0
12
93
1.30
0.30
1.7
2.2
60.42
57.85
%
0.15
12
93
31
269
1.16
0.29
4.9
3.7
—
—
—
0
0
15
121
1.24
0.28
1.2
1.2
—
—
—
0
0
9
76
1.19
0.24
1.0
1.1
—
—
—
0
0
9
77
1.17
0.24
1.0
1.1
—
—
—
0
0
19
162
1.18
0.23
2.1
6.2
1.34
1.20
mmol/l
0.40
12
145
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
5
39
1.28
0.23
1.2
1.3
79.00
77.54
umol/l
—
5
39
23
200
1.16
0.22
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
22
192
1.15
0.21
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
53
1.13
0.18
1.0
1.1
—
—
—
0
0
11
132
0.83
0.18
3.5
3.9
27.67
30.77
mg/l
—
6
93
16
138
1.16
0.17
1.3
1.4
43.00
244.72
miu/ml
—
6
69
9
78
1.16
0.15
1.0
1.1
—
—
—
0
0
187
1920
0.96
0.14
3.2
2.8
—
—
—
0
0
122
1193
1.03
0.08
3.3
3.0
0.66
0.75
ug/l
0.62
83
795
6
75
0.80
0.07
2.5
1.2
—
—
—
0
0
11
101
1.09
0.04
3.2
1.8
199.82
223.13
pmol/l
0.35
11
94
28
285
0.98
0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
2.22
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
53
0.94
-0.00
1.4
3.8
15.82
73.89
u/ml
—
5
53
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
14
140
1.00
-0.00
2.4
2.3
16.75
100.01
ug/min
—
8
80
0
5
0.00
-0.00
0.0
1.0
—
9.55
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
3.2
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.8
—
0.24
—
0
5
0
9
0.00
-0.00
0.0
7.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint K11_ACHAL and mortality.

Females

Parameter HR [95% CI] p-value
K11_ACHAL 1.679 [1.43, 1.97] < 0.001
Birth year 0.994 [0.99, 1.0] 0.159

During the follow-up period (1.1.1998 — 31.12.2019), 400 out of 1422 females with K11_ACHAL died.

Males

Parameter HR [95% CI] p-value
K11_ACHAL 1.729 [1.48, 2.03] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 597 out of 1737 males with K11_ACHAL died.

Mortality risk

Mortality risk for people of age

years, who have K11_ACHAL.

N-year risk Females Males
1 0.182% 0.257%
5 1.003% 1.676%
10 2.602% 4.449%
15 4.928% 8.826%
20 8.809% 15.009%

Relationships between endpoints

↥

Index endpoint: K11_ACHAL – Achalasia of cardia

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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