No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
541 |
4. Check minimum number of eventsNone |
541 |
5. Include endpointsNone |
541 |
6. Filter based on genotype QC (FinnGen only) |
541 |
Control definitions (FinnGen only)
- Control exclude
- K11_LIVER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K70-K77
- Name in latin
- Morbus hepatis toxicus
Similar endpoints
↥List of similar endpoints to
Toxic liver disease
based on the number of shared cases.
Similar with more cases:
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3897 | 2092 | 1772 |
| Only index persons | 3296 | 1812 | 1484 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.05 |
| Only index persons | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 56.47 | 57.86 | 54.71 |
| Only index persons | 55.21 | 56.21 | 53.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 541 | 314 | 227 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.10 |
| Median age at first event (years) | 54.98 | 54.18 | 56.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 483
- Matched controls
- 4832
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K71.2
ICD-10 Finland
Toxic liver disease with acute hepatitis
+∞
244.1
213
*
K71.9
ICD-10 Finland
Toxic liver disease, unspecified
1660.4
134.0
124
*
K71.0
ICD-10 Finland
Toxic liver disease with cholestasis
+∞
76.1
71
*
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
+∞
75.0
70
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
59.8
65.4
76
15
K76.9
ICD-10 Finland
Liver disease, unspecified
206.3
54.2
55
*
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
44.2
50.5
62
16
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.9
39.9
108
193
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
39.9
134
316
A05AA02
ATC
ursodeoxycholic acid; oral
41.7
39.6
49
13
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
32.2
39.6
52
18
K71.1
ICD-10 Finland
Toxic liver disease with hepatic necrosis
+∞
39.1
37
*
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
+∞
28.4
27
*
K70.1
ICD-10 Finland
Alcoholic hepatitis
+∞
26.3
25
*
L04AX01
ATC
azathioprine; systemic
8.9
25.2
55
69
K71.6
ICD-10 Finland
Toxic liver disease with hepatitis, not elsewhere classified
+∞
24.2
23
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
22.0
21
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
+∞
19.9
19
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
+∞
19.9
19
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.7
19.1
90
279
N05CF01
ATC
zopiclone; oral
2.5
18.2
193
1018
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
17.6
171
859
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
9.4
17.5
36
41
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
17.4
237
1409
K71.3
ICD-10 Finland
Toxic liver disease with chronic persistent hepatitis
+∞
15.7
15
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
29.7
15.3
20
7
L04AA06
ATC
mycophenolic acid; systemic
12.4
15.2
27
23
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
14.7
14
*
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
14.7
14
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
37.3
14.5
18
5
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
14.4
123
564
H02AB06
ATC
prednisolone; systemic
2.1
14.3
250
1616
N05AH04
ATC
quetiapine; oral
2.8
14.3
105
442
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.8
14.0
47
106
ZX120
NOMESCO Finland
Intravenous
3.3
13.5
72
244
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
13.3
94
386
WX892
NOMESCO Finland
Monitored bed care
3.7
12.5
55
160
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
12.5
170
973
A06AD11
ATC
lactulose; oral
2.7
12.4
91
378
R94.5
ICD-10 Finland
Abnormal results of liver function studies
12.9
12.2
21
17
Z94.4
ICD-10 Finland
Liver transplant status
47.9
11.9
14
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.2
11.7
36
74
N05CD07
ATC
temazepam; oral
2.9
11.6
74
283
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
11.5
11
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
11.5
11
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
11.5
11
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
122.8
11.5
12
*
N07BB01
ATC
disulfiram; oral
4.5
11.4
40
95
D97
ICPC
Liver disease NOS
44.4
11.0
13
*
H02AB04
ATC
methylprednisolone; systemic
2.6
11.0
86
372
R50.9
ICD-10 Finland
Fever, unspecified
2.6
10.9
84
360
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.9
10.9
30
54
N06AX11
ATC
mirtazapine; oral
2.0
10.7
169
1013
K83.0
ICD-10 Finland
Cholangitis
13.3
10.7
18
14
N02AX02
ATC
tramadol; systemic, rectal
1.9
10.6
218
1446
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
+∞
10.5
10
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.8
10.4
34
75
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
9.9
10.3
20
21
C10AC01
ATC
colestyramine; oral
5.6
10.3
29
54
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.4
10.2
49
154
A02BC02
ATC
pantoprazole; systemic
1.9
10.2
317
2421
UJF32
NOMESCO Finland
Coloscopy
2.1
10.0
134
750
N05BA04
ATC
oxazepam; oral
2.1
10.0
135
758
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
17.2
9.9
15
9
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.7
9.8
71
292
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
9.8
91
428
A07EA06
ATC
budesonide; oral, local oral
5.1
9.8
30
62
127
Kela drug reimbursment
Transplant complication
9.4
9.6
19
21
N05BA01
ATC
diazepam; systemic, rectal
2.5
9.5
81
366
L04AD01
ATC
ciclosporin; systemic
7.8
9.5
21
28
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
9.4
9
*
C03DA01
ATC
spironolactone; oral
2.8
9.4
61
235
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.3
9.3
24
40
N05AH03
ATC
olanzapine; systemic
3.6
9.3
42
126
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
9.2
64
257
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.0
8.8
50
177
H02AB07
ATC
prednisone; oral
2.4
8.6
78
363
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.8
8.6
57
223
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.1
8.5
45
153
K70.0
ICD-10 Finland
Alcoholic fatty liver
91.6
8.4
9
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
13.1
8.4
14
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
8.4
177
1158
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
+∞
8.4
8
*
K71.8
ICD-10 Finland
Toxic liver disease with other disorders of liver
+∞
8.4
8
*
K85
ICD-10 Finland
Acute pancreatitis
7.7
8.2
18
24
UJK02
NOMESCO Finland
ERCP
6.0
8.1
21
36
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
8.1
39
124
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
8.0
118
675
C03CA01
ATC
furosemide; systemic
1.9
8.0
136
824
N06AX12
ATC
bupropion; oral
3.4
8.0
38
119
R53
ICD-10 Finland
Malaise and fatigue
2.0
7.9
110
617
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
7.4
51
205
N06AB04
ATC
citalopram; systemic
2.0
7.4
108
616
K71.7
ICD-10 Finland
Toxic liver disease with fibrosis and cirrhosis of liver
+∞
7.3
7
*
JJ5AT
NOMESCO Finland
NA
+∞
7.3
7
*
K71.4
ICD-10 Finland
Toxic liver disease with chronic lobular hepatitis
+∞
7.3
7
*
N03AX16
ATC
pregabalin; oral
1.9
7.3
119
705
L04AA01
ATC
[U] ciclosporin; systemic
7.5
7.2
16
22
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
7.2
85
444
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.2
178
1211
TK800
NOMESCO Finland
Hemodialysis
5.2
7.2
21
42
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.1
113
664
J01MA12
ATC
levofloxacin; systemic
2.0
7.1
92
502
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.9
7.0
27
72
M05BA04
ATC
alendronic acid; oral
2.7
6.8
44
170
K83.1
ICD-10 Finland
Obstruction of bile duct
9.5
6.8
13
14
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
5.8
6.8
18
32
C07AA05
ATC
propranolol; systemic
1.9
6.8
99
564
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.8
6.8
21
45
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
40.6
6.8
8
*
A02BC05
ATC
esomeprazole; systemic
1.7
6.7
190
1342
N05AX12
ATC
aripiprazole; systemic
3.7
6.6
27
76
K92.0
ICD-10 Finland
Haematemesis
5.5
6.5
18
34
A07EC02
ATC
mesalazine; oral, rectal
3.1
6.5
34
116
N03AE01
ATC
clonazepam; systemic
3.1
6.5
34
116
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
6.5
74
381
K76.89
ICD-10 Finland
Other specified diseases of liver
70.7
6.4
7
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.4
6.4
29
89
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.4
6.3
12
13
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
6.3
61
294
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
6.3
56
259
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
6.3
6
*
K71.5
ICD-10 Finland
Toxic liver disease with chronic active hepatitis
+∞
6.3
6
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
6.2
62
301
R4110
NOMESCO Finland
Physiotherapy
1.8
6.2
133
858
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
6.2
35
123
F05.9
ICD-10 Finland
Delirium, unspecified
5.9
6.2
16
28
P76
ICPC
Depressive disorder
3.0
6.2
35
124
L88
ICPC
Rheumatoid/seropositive arthritis
3.8
6.2
24
65
P01BA02
ATC
hydroxychloroquine; oral
2.5
6.2
46
193
L04AA13
ATC
leflunomide; oral
4.5
6.1
20
46
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
5.7
6.0
16
29
WX882
NOMESCO Finland
High dependency care
4.7
6.0
19
42
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
90
12
89.77
170.23
1.2
1.1
—
—
—
0
0
202
344
8.78
123.67
3.9
2.1
0.2
0.2
g/l
3.84
186
325
183
293
8.93
117.77
2.4
2.6
10.5
10.2
g/l
0.55
176
269
92
65
16.85
103.95
4.9
2.6
39.1
31.2
umol/l
0.88
84
53
63
25
28.39
91.42
1.3
1.0
—
—
titre
—
0
0
201
478
6.10
85.51
7.3
2.4
26.3
7.4
umol/l
4.73
186
421
80
78
11.86
73.84
4.1
6.6
1177.3
495.9
iu/ml
—
8
11
76
76
11.47
68.84
1.2
1.3
—
—
—
0
0
75
74
11.61
68.55
1.2
1.3
231.3
236.1
u/ml
0.04
49
42
329
1415
4.38
62.88
9.7
3.1
111.2
30.2
u/l
4.40
318
1348
51
31
18.06
61.52
1.2
1.0
—
—
—
0
0
370
1774
4.43
59.71
9.6
4.3
34.5
36.0
g/l
5.80
356
1650
64
68
10.54
55.29
1.5
1.4
95.7
110.3
u/ml
—
10
15
412
2240
4.52
53.19
15.2
5.8
22.8
10.9
umol/l
6.54
401
2123
64
72
9.95
52.99
1.6
1.4
—
—
—
0
0
74
127
6.59
42.50
1.2
1.3
—
—
—
0
0
245
1060
3.40
42.09
10.9
3.4
86.4
92.5
%
2.83
240
1034
284
1348
3.33
41.75
4.5
2.4
55.7
55.9
u/l
0.03
272
1256
161
547
3.77
40.16
3.0
2.3
26.6
22.6
%
1.85
143
477
161
588
3.47
35.47
3.2
2.2
2.3
2.4
g/l
0.43
150
547
111
335
3.91
32.34
12.7
6.7
8.7
9.2
mmol/l
0.31
103
320
122
396
3.69
31.94
4.7
2.1
49.1
33.6
u/l
0.51
109
334
163
641
3.21
31.38
3.3
2.3
14.6
13.3
umol/l
0.98
157
589
347
2079
2.87
30.17
10.7
6.0
27.6
28.3
%
0.50
330
1945
141
521
3.31
29.97
3.1
1.8
1.7
1.5
%
3.35
126
464
29
23
13.27
29.97
6.1
1.7
102.1
104.5
%
0.09
29
23
340
2049
2.77
28.64
10.3
5.8
57.3
57.0
%
0.20
326
1928
466
3346
3.83
28.28
19.7
7.1
115.6
76.8
u/l
10.10
453
3129
388
2525
2.90
27.74
16.1
9.1
4.2
4.0
e9/l
0.96
349
2204
24
17
14.73
26.36
1.9
2.7
160.3
102.2
umol/l
—
11
10
315
1895
2.59
25.53
10.1
5.7
1.2
1.2
mmol/l
2.10
295
1719
27
25
11.31
25.29
1.6
1.6
—
—
—
0
0
119
443
3.16
24.58
5.8
4.4
256.2
254.0
u/l
0.04
112
421
420
2974
2.84
23.29
8.7
2.9
123.1
43.0
u/l
7.91
403
2786
329
2082
2.48
23.00
12.1
6.5
1.2
1.2
mmol/l
0.65
273
1760
145
659
2.64
20.34
6.3
3.3
0.8
0.8
mmol/l
0.58
140
625
258
1530
2.31
20.01
4.4
3.1
—
—
—
0
0
195
1030
2.40
19.74
3.1
2.1
2.6
3.1
mg/l
2.81
167
887
214
1185
2.33
19.36
4.1
2.9
0.6
0.4
e6/l
0.60
169
876
24
28
8.92
19.03
1.2
1.2
—
—
—
0
0
121
529
2.66
18.16
10.2
5.3
1.0
1.0
mmol/l
0.03
115
494
142
673
2.50
18.02
2.1
1.9
—
—
—
0
0
293
1894
2.19
17.72
4.3
2.7
319.7
116.1
ug/l
2.05
268
1750
33
60
5.79
17.64
1.3
1.2
—
—
—
0
0
358
2529
2.23
17.01
9.5
4.6
6.7
6.7
mmol/l
0.01
338
2352
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
42
99
4.52
16.74
3.5
2.4
0.3
0.3
u/ml
0.63
23
54
107
464
2.63
16.19
1.9
1.8
—
—
—
0
0
107
470
2.59
15.75
1.9
1.9
—
—
—
0
0
175
969
2.19
15.14
1.3
1.2
0.9
1.4
u/ml
0.45
32
275
421
3252
2.33
15.02
6.9
4.0
16.6
11.4
mm/h
7.21
394
2993
76
298
2.80
13.90
1.8
1.6
—
—
—
0
0
305
2123
2.00
13.82
4.5
3.6
0.0
0.0
estimate
0.00
57
402
264
1754
1.99
13.61
3.4
2.2
76.2
76.3
nmol/l
0.01
248
1567
88
376
2.60
13.60
7.5
4.0
1.4
2.0
mmol/l
0.94
76
302
137
714
2.23
13.59
3.4
2.6
1.4
1.0
e6/l
0.51
81
394
211
1302
2.02
13.38
2.9
2.0
138.7
235.8
u/l
1.14
200
1224
49
153
3.42
13.21
3.4
2.9
18.8
1289.4
u/ml
0.79
42
132
171
993
2.06
12.71
1.7
1.5
19.2
21.5
nmol/l
1.11
153
839
128
666
2.21
12.66
3.6
2.8
2.9
2.2
e6/l
0.37
72
347
144
799
2.09
12.01
5.6
3.8
295.3
310.7
ng/l
0.04
117
600
51
177
3.08
11.57
1.9
2.0
1.3
1.5
g/l
0.97
45
157
300
2168
1.86
11.21
4.5
3.6
0.0
0.0
estimate
0.50
55
389
207
1334
1.89
11.09
5.1
3.2
7.9
7.7
mmol/l
0.20
171
1108
246
1682
1.85
10.88
2.3
1.9
97.5
96.5
pmol/l
0.10
128
850
219
1452
1.85
10.63
4.3
3.3
2.3
2.4
mmol/l
0.31
192
1278
94
462
2.25
10.55
9.7
7.6
4.9
5.1
kpa
0.99
87
444
94
462
2.25
10.55
9.7
7.6
11.4
12.2
kpa
0.97
87
447
294
2137
1.82
10.53
5.8
4.8
0.0
0.0
estimate
0.50
57
405
17
27
6.47
10.33
2.5
1.4
0.9
1.0
g/l
0.50
17
27
99
515
2.13
9.60
19.1
21.1
1.0
1.3
inr
4.85
12
70
91
461
2.17
9.43
10.0
7.7
1.1
1.1
mmol/l
0.03
61
370
127
735
1.95
9.16
1.9
1.7
1217.3
1188.8
nmol/l
0.10
100
558
83
411
2.20
9.09
3.4
4.2
27.7
18.5
ug/l
0.14
72
333
32
100
3.34
8.63
1.4
1.8
—
—
—
0
0
40
145
2.90
8.42
7.8
3.3
1.6
1.5
mg/l
0.48
40
132
23
60
3.96
8.05
1.0
1.1
—
—
—
0
0
12
18
6.80
7.63
4.3
1.4
25.8
30.8
umol/l
0.81
12
18
146
954
1.73
6.90
6.6
3.9
1.0
1.0
kg/l
0.39
21
127
265
2018
1.61
6.89
5.7
3.9
—
—
—
0
0
26
83
3.24
6.80
4.9
3.3
3.5
4.1
e9/l
0.65
26
83
38
154
2.58
6.50
3.7
2.1
—
—
—
0
0
26
86
3.13
6.43
5.3
3.7
54.3
56.1
%
0.27
26
86
47
213
2.32
6.34
13.8
8.6
23.6
24.5
mmol/l
1.18
40
203
488
4405
2.10
6.32
29.5
13.2
20.3
22.7
mg/l
1.17
435
3444
151
1018
1.67
6.29
4.4
2.2
—
—
—
0
0
123
788
1.73
6.17
4.0
2.8
2.5
2.4
mmol/l
1.06
102
688
25
83
3.11
6.15
1.6
1.2
—
—
—
0
0
25
83
3.11
6.15
1.6
1.2
—
—
—
0
0
51
243
2.21
6.12
1.8
1.7
—
—
—
0
0
36
148
2.53
6.00
1.8
1.6
0.0
0.0
iu/ml
—
6
26
496
4525
2.16
5.91
31.2
15.0
139.1
139.7
mmol/l
5.54
485
4397
78
441
1.90
5.90
4.3
3.1
—
—
—
0
0
32
126
2.64
5.81
3.9
2.2
81.3
92.7
%
1.26
32
119
52
258
2.12
5.65
1.7
1.4
—
—
—
0
0
52
258
2.12
5.65
3.3
3.7
4.3
4.5
pmol/l
0.63
44
226
496
4539
2.12
5.63
31.6
15.1
3.9
4.0
mmol/l
1.09
485
4405
51
252
2.13
5.60
6.7
8.3
23.3
24.5
mmol/l
1.05
46
236
424
3707
1.66
5.57
35.3
16.2
14.2
13.6
%
5.24
417
3639
13
29
4.57
5.53
2.0
2.2
—
—
—
0
0
179
1299
1.56
5.39
4.4
4.1
9.5
7.3
mg/mmol
0.25
110
804
36
158
2.37
5.24
1.7
1.8
1.6
3.7
ug/l
0.51
31
144
34
146
2.42
5.19
3.7
3.7
1.6
1.3
mmol/l
1.02
34
141
31
131
2.45
4.91
2.3
2.0
478.2
289.0
ug/l
0.48
31
122
215
1657
1.49
4.77
4.6
3.6
100.5
37.8
ng/l
0.60
146
1128
43
212
2.12
4.77
5.4
3.4
1.2
1.2
%
0.06
43
212
157
1134
1.54
4.73
3.3
2.6
4487.3
5752.5
umol/l
0.15
142
975
449
4048
1.64
4.51
6.1
4.7
1.9
2.2
mu/l
0.45
423
3699
16
49
3.33
4.50
3.7
3.6
—
—
—
0
0
21
76
2.83
4.50
1.7
1.8
—
—
—
0
0
29
125
2.39
4.42
1.4
1.2
—
—
—
0
0
21
78
2.76
4.30
1.8
1.4
—
—
—
0
0
26
108
2.48
4.29
1.7
1.7
—
—
—
0
0
31
141
2.27
4.20
1.2
1.1
—
—
—
0
0
31
141
2.27
4.20
1.2
1.1
—
—
—
0
0
25
104
2.47
4.12
1.7
1.8
—
—
—
0
0
15
47
3.25
4.08
2.1
1.7
—
—
—
0
0
14
43
3.32
3.93
1.4
1.1
1.3
1.7
nmol/l
0.42
14
36
27
120
2.32
3.87
1.6
1.4
351.8
329.0
ug/g
0.21
19
68
61
367
1.75
3.78
3.0
2.4
7.5
7.1
ug/l
0.07
53
325
12
34
3.59
3.78
1.2
1.1
—
—
—
0
0
12
34
3.59
3.78
1.2
1.1
—
—
—
0
0
20
78
2.62
3.76
1.2
1.7
—
—
—
0
0
29
135
2.21
3.74
3.1
2.2
1038.1
2657.5
u/l
—
9
48
12
35
3.48
3.63
1.2
1.1
—
—
—
0
0
12
35
3.48
3.63
1.2
1.1
—
—
—
0
0
12
35
3.48
3.63
1.2
1.1
—
—
—
0
0
57
341
1.75
3.61
4.2
3.6
1.2
1.2
mmol/l
1.18
52
298
28
131
2.20
3.58
4.1
2.5
—
—
—
0
0
27
125
2.22
3.54
1.5
2.9
37.2
94.7
mg/l
0.60
22
101
27
125
2.22
3.54
1.5
2.9
26.3
30.0
mg/l
0.44
22
101
133
980
1.47
3.53
2.3
1.7
1.7
1.1
mg/l
0.71
106
748
24
106
2.32
3.50
2.1
1.9
3.0
6.6
iu/l
—
6
38
18
69
2.66
3.50
4.4
3.2
0.8
1.0
%
0.24
12
55
6
6
10.09
3.50
1.0
3.8
—
—
—
0
0
7
10
7.07
3.37
1.0
1.0
—
—
—
0
0
209
1687
1.39
3.33
4.9
3.6
—
—
—
0
0
13
43
3.07
3.27
2.1
1.8
—
—
—
0
0
376
3355
1.40
3.15
5.3
3.9
14.8
14.7
pmol/l
0.36
353
3047
119
879
1.45
3.10
1.8
1.7
158824078.0
5494939.2
pmol/l
0.47
102
728
152
1176
1.41
3.07
5.7
3.8
0.0
0.0
estimate
0.69
57
398
150
1164
1.40
2.96
1.9
1.7
1.5
1.4
mmol/l
0.40
133
987
13
47
2.81
2.83
2.5
1.3
—
—
—
0
0
15
59
2.59
2.81
1.2
1.7
—
—
—
0
0
12
42
2.90
2.76
1.7
1.7
—
—
—
0
0
12
42
2.90
2.76
1.7
1.7
—
—
—
0
0
12
42
2.90
2.76
1.7
1.7
—
—
—
0
0
24
118
2.08
2.76
1.6
1.5
—
—
—
0
0
28
147
1.95
2.70
1.6
2.0
—
—
—
0
0
11
37
3.01
2.70
1.4
1.7
—
—
—
0
0
25
126
2.03
2.70
1.3
1.3
488.2
226.1
miu/ml
—
6
65
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
24
3.79
2.68
1.1
1.2
—
—
—
0
0
152
1200
1.37
2.68
2.8
3.1
1863.5
1068.5
ng/l
0.89
134
1009
497
4722
1.65
2.61
26.3
9.9
58.5
26.3
u/l
3.90
488
4553
19
87
2.23
2.60
2.9
2.2
132.9
127.7
g/l
0.29
14
64
320
2829
1.32
2.57
3.2
3.1
—
—
—
0
0
19
88
2.20
2.54
1.6
1.3
3.5
3.8
mmol/l
0.61
19
82
13
51
2.59
2.46
1.4
1.1
—
—
—
0
0
10
34
2.98
2.42
24.6
17.4
1705.9
1699.1
nmol/l
—
10
34
18
84
2.18
2.37
2.7
2.5
18.4
15.8
%
—
7
44
9
28
3.25
2.31
1.6
1.8
—
—
—
0
0
9
28
3.25
2.31
1.6
1.8
—
—
—
0
0
7
18
3.92
2.26
1.6
2.1
57.1
81.0
ug/l
—
7
18
47
305
1.59
2.25
1.2
1.2
167.0
141.1
iu/ml
0.16
18
128
5
9
5.59
2.22
1.2
2.0
—
—
—
0
0
38
235
1.66
2.20
1.2
1.3
—
—
—
0
0
14
61
2.33
2.16
1.1
1.7
—
—
—
0
0
6
14
4.32
2.15
1.0
1.1
—
—
—
0
0
15
68
2.24
2.13
1.2
1.7
—
—
—
0
0
12
49
2.48
2.11
1.7
1.8
33.8
32.9
pg
0.25
12
49
446
4185
1.37
2.11
25.2
12.0
81.5
81.9
ml/min/173m2
0.13
393
3451
8
25
3.23
2.10
1.1
2.4
—
—
—
0
0
27
154
1.79
2.08
2.4
1.6
—
—
—
0
0
41
264
1.60
2.05
6.3
3.5
0.8
1.6
mmol/l
0.57
33
196
26
149
1.78
1.98
1.9
1.6
—
—
—
0
0
7
21
3.36
1.97
1.1
1.4
—
—
—
0
0
14
64
2.22
1.96
1.5
1.7
—
—
—
0
0
19
100
1.93
1.87
1.6
1.4
521.7
441.6
mg/l
0.61
19
95
21
115
1.86
1.85
1.6
1.2
12.8
9.6
u/l
0.39
14
90
6
17
3.56
1.84
1.0
1.0
—
—
—
0
0
8
29
2.78
1.79
1.3
1.7
—
—
—
0
0
10
41
2.47
1.76
1.5
1.2
—
—
—
0
0
10
41
2.47
1.76
1.5
1.2
—
—
—
0
0
6
18
3.36
1.75
1.2
1.0
—
—
—
0
0
27
163
1.69
1.75
2.8
1.8
—
—
—
0
0
11
48
2.32
1.71
1.6
1.8
—
—
—
0
0
450
4275
1.31
1.58
5.0
4.4
6.2
5.9
mmol/l
2.28
420
3918
6
20
3.02
1.58
1.7
1.2
—
—
—
0
0
430
4068
1.28
1.51
32.4
14.1
38.9
40.1
%
2.18
315
3011
51
370
1.42
1.50
6.5
2.7
58.0
67.1
ml/min/173m2
0.66
18
154
12
59
2.06
1.44
1.8
1.4
—
—
—
0
0
9
39
2.33
1.43
1.4
1.3
—
—
—
0
0
9
39
2.33
1.43
1.8
1.1
—
—
—
0
0
7
29
2.43
1.39
1.4
1.4
—
—
—
0
0
12
60
2.02
1.39
1.8
1.4
—
—
—
0
0
12
60
2.02
1.39
1.8
1.4
—
—
—
0
0
12
60
2.02
1.39
1.8
1.4
—
—
—
0
0
12
60
2.02
1.39
1.8
1.4
—
—
—
0
0
18
104
1.76
1.38
1.8
1.4
—
—
—
0
0
18
104
1.76
1.38
1.4
1.4
—
—
—
0
0
27
175
1.57
1.37
7.7
3.8
24.8
24.8
mmol/l
0.01
27
169
5
17
2.96
1.36
2.6
1.9
—
—
—
0
0
5
17
2.96
1.36
2.6
1.9
—
—
—
0
0
12
61
1.99
1.33
1.8
1.4
—
—
—
0
0
6
24
2.52
1.30
2.3
1.7
—
—
—
0
0
6
24
2.52
1.30
2.3
1.7
—
—
—
0
0
6
24
2.52
1.30
2.3
1.7
—
—
—
0
0
6
24
2.52
1.30
2.3
1.7
—
—
—
0
0
5
18
2.79
1.28
2.6
1.9
—
—
—
0
0
5
18
2.79
1.28
1.6
1.9
2.0
13.1
nmol/l
—
5
13
95
780
1.26
1.24
1.3
1.3
30.5
31.6
iu/ml
0.04
27
252
6
25
2.42
1.24
1.7
1.3
—
—
—
0
0
6
25
2.42
1.24
1.7
1.3
—
—
—
0
0
5
19
2.65
1.22
1.8
1.1
—
—
—
0
0
6
26
2.32
1.19
1.7
3.1
—
—
—
0
0
28
194
1.47
1.09
1.5
1.3
22.5
26.5
iu/l
0.30
19
165
19
121
1.59
1.07
1.6
1.3
—
—
—
0
0
16
98
1.65
1.04
2.4
1.8
—
—
—
0
0
5
23
2.18
0.98
2.8
3.1
1548.0
861.3
u/ml
—
5
23
5
23
2.18
0.98
1.6
1.3
—
—
—
0
0
5
23
2.18
0.98
1.6
1.3
—
—
—
0
0
5
23
2.18
0.98
1.0
1.0
181.4
93.3
u/l
—
5
18
5
23
2.18
0.98
1.0
1.0
73.6
35.5
u/l
—
5
18
454
4380
1.23
0.98
5.3
4.4
4.7
4.7
mmol/l
0.26
427
4075
424
4069
1.19
0.94
7.2
5.6
40.5
39.7
mmol/mol
0.63
400
3802
53
421
1.29
0.93
2.3
2.0
—
—
—
0
0
10
55
1.83
0.92
1.2
1.3
0.6
0.6
nmol/l
—
10
49
90
764
1.21
0.90
1.4
1.3
6.0
9.7
u/ml
0.37
30
299
93
793
1.21
0.89
1.3
1.5
—
—
—
0
0
82
693
1.22
0.86
1.5
1.4
—
—
—
0
0
58
472
1.26
0.85
2.4
2.1
—
—
—
0
0
6
31
1.95
0.84
1.2
1.0
—
—
—
0
0
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
10
165
0.60
0.83
1.7
1.5
—
—
—
0
0
8
46
1.75
0.83
1.0
1.1
—
—
—
0
0
33
429
0.75
0.82
1.8
1.7
—
—
—
0
0
6
33
1.83
0.79
1.2
1.1
—
—
—
0
0
450
4362
1.19
0.78
5.1
4.3
1.5
1.5
mmol/l
0.05
421
4043
17
115
1.49
0.77
1.2
1.4
—
—
—
0
0
16
107
1.51
0.77
1.8
1.5
8819.3
16175.6
e6/l
—
9
80
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
9
56
1.62
0.72
1.0
1.0
—
—
—
0
0
7
42
1.68
0.68
1.1
1.4
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
95
1072
0.86
0.64
3.6
4.1
24.6
21.3
%
0.94
38
497
5
29
1.73
0.64
1.0
1.3
—
—
—
0
0
458
4465
1.17
0.63
5.9
4.8
2.7
2.8
mmol/l
1.84
434
4130
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
19
139
1.38
0.61
1.5
1.5
—
—
—
0
0
6
37
1.63
0.55
1.0
1.2
—
0.1
u/ml
—
0
18
501
4934
1.21
0.52
43.2
19.6
131.7
135.7
g/l
6.56
492
4864
6
41
1.47
0.50
5.5
2.2
—
—
—
0
0
16
119
1.36
0.48
1.2
1.1
—
—
—
0
0
37
310
1.21
0.47
2.0
2.2
12.7
13.3
nmol/l
0.18
32
285
28
230
1.23
0.43
2.6
1.8
—
—
—
0
0
5
32
1.57
0.42
1.4
1.8
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
6
43
1.40
0.35
6.5
3.1
120.9
54.8
u/ml
—
6
43
71
779
0.90
0.34
2.8
3.0
0.7
0.7
ug/l
0.36
43
490
10
74
1.36
0.32
1.2
1.1
—
—
—
0
0
7
52
1.35
0.31
1.0
1.1
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
—
—
0
0
125
1323
0.93
0.28
4.5
4.7
2.0
2.4
ug/l
0.60
114
1192
58
529
1.11
0.27
11.4
6.9
—
—
—
0
0
8
64
1.25
0.27
1.0
1.1
—
—
—
0
0
21
180
1.17
0.24
2.5
1.8
—
—
—
0
0
5
42
1.19
0.21
1.0
1.6
15.4
17.8
ug/l
—
5
42
0
11
0.00
0.21
0.0
2.2
—
2.7
—
0
5
8
104
0.77
0.21
1.8
1.5
—
—
—
0
0
16
186
0.86
0.19
1.3
1.9
1.7
2.8
mg/l
0.95
11
133
427
4223
1.05
0.17
4.9
3.9
1.3
1.3
mmol/l
0.71
398
3899
5
70
0.71
0.17
1.4
1.5
—
—
—
0
0
51
542
0.93
0.14
5.6
4.4
32.6
31.6
%
0.24
42
362
8
99
0.81
0.13
1.6
1.4
—
—
—
0
0
8
99
0.81
0.13
1.6
1.4
—
—
—
0
0
8
99
0.81
0.13
1.6
1.4
—
—
—
0
0
13
146
0.89
0.10
1.5
1.4
—
—
—
0
0
13
116
1.12
0.09
1.3
1.3
—
—
—
0
0
5
61
0.82
0.08
1.0
1.5
—
—
—
0
0
7
66
1.06
0.08
1.9
1.8
—
—
—
0
0
23
219
1.05
0.04
1.0
1.0
—
—
—
0
0
12
111
1.08
0.04
1.3
1.5
—
—
—
0
0
14
149
0.94
0.03
2.6
1.8
—
—
—
0
0
10
94
1.07
0.01
1.4
1.7
171.8
221.9
pmol/l
—
10
87
0
9
0.00
0.00
0.0
1.0
—
17.7
—
0
9
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
60.3
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
7
77
0.91
0.00
1.0
1.2
16.0
13.6
u/l
—
7
64
0
8
0.00
0.00
0.0
1.0
—
7.6
—
0
8
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_TOXLIV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_TOXLIV | 2.305 [1.95, 2.72] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.287 |
During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 1710 females with K11_TOXLIV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_TOXLIV | 3.07 [2.52, 3.74] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 519 out of 1402 males with K11_TOXLIV died.
Mortality risk
Mortality risk for people of age
years, who have K11_TOXLIV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.296% | 0.643% |
| 5 | 1.451% | 3.723% |
| 10 | 3.399% | 8.851% |
| 15 | 6.4% | 17.475% |
| 20 | 11.149% | 28.193% |
Relationships between endpoints
↥Index endpoint: K11_TOXLIV – Toxic liver disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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