Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified

O15_LABOUR_INTRAPART_HAEMORRH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O67
  • Hospital discharge: ICD-9 641[3-9]B
  • Hospital discharge: ICD-8 6530
  • Cause of death: ICD-10 O67
  • Cause of death: ICD-9 641[3-9]B
  • Cause of death: ICD-8 6530

2 out of 7 registries used, show all original rules.

1945

4. Check minimum number of events

None

1945

5. Include endpoints

None

1945

6. Filter based on genotype QC (FinnGen only)

1945

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O60-O75
Name in latin
Labores et partus ab haemorrhagia intra partum complicati non alibi classificati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15421 15421 -
Only index persons 14972 14972 -
Unadjusted period prevalence (%)
Whole population 0.44 0.44 -
Only index persons 0.55 0.55 -
Median age at first event (years)
Whole population - 27.74 -
Only index persons - 27.72 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1945 1945 -
Unadjusted period prevalence (%) 0.66 0.66 -
Median age at first event (years) 27.45 27.45 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1745
Matched controls
17450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
65300
ICD-8 Finland
Occipital presentation
+∞
323.0
1159
*
O67.9
ICD-10 Finland
Intrapartum haemorrhage, unspecified
+∞
323.0
336
*
O67.8
ICD-10 Finland
Other intrapartum haemorrhage
+∞
113.8
108
*
63497
ICD-8 Finland
Other complications of pregnancy, Partus prematurus imminens, alibi non classificabilis
+∞
78.7
75
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
5.9
69.1
207
390
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
+∞
62.9
60
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
13.8
62.0
109
84
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
7.3
47.0
117
170
6418B
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Other antepartum haemorrhage[ALIA HAEMORRHAGIA IN GRAVIDITATE,SYNN PÄÄTT HOITOJ]
+∞
43.9
42
*
O81.4
ICD-10 Finland
Vacuum extractor delivery
16.2
42.9
70
45
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
375.0
37.1
37
*
O72.0
ICD-10 Finland
Third-stage haemorrhage
+∞
36.6
35
*
65310
ICD-8 Finland
Occipital presentation
+∞
35.5
34
*
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
+∞
35.5
34
*
MAE00
NOMESCO Finland
Outlet vacuum delivery
14.2
34.5
59
43
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
343.6
34.0
34
*
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
178.4
33.8
35
*
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
+∞
30.3
29
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
2.2
29.5
351
1800
65200
ICD-8 Finland
Occipital presentation
+∞
29.2
28
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.7
27.8
200
786
O60
ICD-10 Finland
Preterm labour and delivery
275.1
26.8
27
*
6419B
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Unspecified antepartum haemorrhage[HAEMORRHAGIA NUD IN GRAVIDITATE,SYNN PÄÄTT HOITOJ]
+∞
26.1
25
*
65210
ICD-8 Finland
Occipital presentation
+∞
26.1
25
*
O67.0
ICD-10 Finland
Intrapartum haemorrhage with coagulation defect
+∞
26.1
25
*
SPAT1197
SPAT
Extensive health check-up of expecting family
2.7
26.1
197
796
SPAT1324
SPAT
Screening procedure
1.8
25.2
540
3442
6441A
ICD-9 Finland
Early or threatened labour, Other threatened labour
+∞
24.0
23
*
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
38.1
24.0
30
8
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.3
23.4
235
1102
SPAT1196
SPAT
Monitoring of normal pregnancy
3.0
23.0
141
499
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
32.7
22.4
29
9
SPAT1379
SPAT
Health check-up of pregnant person
2.6
22.1
165
662
6660A
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM STADII III]
+∞
21.9
21
*
O23.5
ICD-10 Finland
Infections of the genital tract in pregnancy
10.7
21.4
41
39
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
+∞
20.9
20
*
6440B
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]
+∞
20.9
20
*
W84
ICPC
Pregnancy high risk
4.5
20.0
72
166
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
+∞
19.8
19
*
SPAT1380
SPAT
Postpartum check-up
2.7
19.0
136
532
6661A
ICD-9 Finland
Postpartum haemorrhage, Other immediate postpartum haemorrhage[HAEMORRHAGIA POST PARTUM ATONICA UTERI]
+∞
18.8
18
*
W78
ICPC
Pregnancy
2.2
18.7
201
969
SPAT1189
SPAT
Other ultrasound examination during pregnancy
4.4
18.5
67
156
O75.0
ICD-10 Finland
Maternal distress during labour and delivery
+∞
17.7
17
*
MBA04
NOMESCO Finland
Curettage of uterus after delivery
96.0
17.6
19
*
O61.0
ICD-10 Finland
Failed medical induction of labour
+∞
16.7
16
*
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
+∞
16.7
16
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.4
16.3
140
604
WX307
NOMESCO Finland
Obstetric epidural analgesia
2.7
15.9
113
440
O82.0
ICD-10 Finland
Delivery by elective caesarean section
3.3
15.8
80
249
8811
FHL
Cesarean section
2.9
15.7
98
353
O68.3
ICD-10 Finland
Labour and delivery complicated by biochemical evidence of fetal stress
+∞
15.6
15
*
65301
ICD-8 Finland
Face and brow presentation
+∞
15.6
15
*
SPAT1357
SPAT
Monitoring of problem during pregnancy
4.1
15.0
59
149
6522B
ICD-9 Finland
Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,SYNNYTYKSEN AIKANA]
+∞
14.6
14
*
66030
ICD-8 Finland
Occipital presentation
+∞
14.6
14
*
65580
ICD-8 Finland
Occipital presentation
+∞
14.6
14
*
Z3232
NOMESCO Finland
Midwife
2.2
14.5
148
698
8221
FHL
Sterilization of the laparotomy pathway
2.7
14.3
102
399
O99.80
ICD-10 Finland
The fear of childbirth
3.1
14.3
78
257
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
2.1
14.0
160
793
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.0
13.9
187
990
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.0
13.8
199
1079
O80.8
ICD-10 Finland
Other single spontaneous delivery
3.2
13.6
71
228
65307
ICD-8 Finland
Multiple pregnancy, all presentations
+∞
13.6
13
*
O75.6
ICD-10 Finland
Delayed delivery after spontaneous or unspecified rupture of membranes
+∞
13.6
13
*
65400
ICD-8 Finland
Occipital presentation
+∞
13.6
13
*
63499
ICD-8 Finland
Other complications of pregnancy, Other
3.5
13.2
62
183
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.1
13.1
150
743
8831
FHL
Uterine exploration and / or scraping or suction emptying (ad 24 hours)
28.6
13.0
17
6
6660C
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC PARTIALI]
+∞
12.5
12
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.2
11.9
120
561
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
5.2
11.7
35
68
O68.8
ICD-10 Finland
Labour and delivery complicated by other evidence of fetal stress
+∞
11.5
11
*
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
+∞
11.5
11
*
SPAT1308
SPAT
Sexual health counselling
1.8
11.3
192
1102
ZXD00
NOMESCO Finland
Emergency procedure
3.7
11.2
48
133
Y6099
ICD-8 Finland
Prenatal care and observation
2.0
11.1
143
745
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
4.4
11.0
39
91
SPAT1193
SPAT
Pap smear
1.7
10.8
216
1308
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
10.7
640
5033
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.1
10.6
118
580
6535B
ICD-9 Finland
Disproportion, Unusually large foetus causing disproportion[EPÄTAVALLISEN ISO SIKIÖ (YLI 4500 G), SYNN AIKANA]
+∞
10.4
10
*
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
2.8
10.0
63
231
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
5.8
10.0
27
47
WX234
NOMESCO Finland
Paracervical blockade
2.9
9.5
56
197
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.0
9.4
122
635
65320
ICD-8 Finland
Occipital presentation
7.6
9.4
21
28
O73.1
ICD-10 Finland
Retained portions of placenta and membranes, without haemorrhage
+∞
9.4
9
*
65304
ICD-8 Finland
Occipital presentation, posterior position
+∞
9.4
9
*
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
8.3
9.1
19
23
V252A
ICD-9 Finland
Contraceptive management, Sterilisation
1.6
9.0
248
1642
SPAT1240
SPAT
Therapeutic discussion
1.7
8.9
186
1139
O32.1
ICD-10 Finland
Maternal care for breech presentation
2.7
8.9
60
230
N81.1
ICD-10 Finland
Cystocele
1.8
8.8
150
863
ZXD05
NOMESCO Finland
Urgent procedure
1.4
8.7
404
3006
Z36.8
ICD-10 Finland
Other antenatal screening
3.8
8.6
35
94
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
1.8
8.6
150
872
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.6
8.6
228
1493
SPAT1200
SPAT
Guidance for breast-feeding and breast care
3.3
8.6
41
126
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
4.4
8.5
29
66
64399
ICD-8 Finland
Spontaneous abortion, Without mention of sepsis or toxaemia
2.0
8.5
103
524
N81.6
ICD-10 Finland
Rectocele
1.8
8.5
154
908
63701
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Hypertonia
2.7
8.3
53
198
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
6.5
8.2
20
31
SPAT1373
SPAT
Combined screening in early pregnancy
4.4
8.1
28
65
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
3.1
8.1
43
143
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.0
8.1
96
487
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.8
8.0
139
806
SPAT1192
SPAT
Gynaecological examination
1.7
8.0
171
1059
Z2221
NOMESCO Finland
Medical doctor
0.7
8.0
252
3483
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
2.8
7.7
49
180
Z36
ICD-10 Finland
Antenatal screening
18.4
7.6
11
6
63230
ICD-8 Finland
Haemorrhage of pregnancy, Threatened abortion
2.1
7.3
77
372
O30.0
ICD-10 Finland
Twin pregnancy
4.2
7.3
26
63
65306
ICD-8 Finland
Complete or incomplete breech presentation
+∞
7.3
7
*
66130
ICD-8 Finland
Occipital presentation
+∞
7.3
7
*
6671A
ICD-9 Finland
Retained placenta or membranes, without haemorrhage, Retained portions of placenta or membranes, without haemorrhage
+∞
7.3
7
*
O64.8
ICD-10 Finland
Obstructed labour due to other malposition and malpresentation
+∞
7.3
7
*
O70.2
ICD-10 Finland
Third degree perineal laceration during delivery
+∞
7.3
7
*
65308
ICD-8 Finland
Other or imprecisely defined presentation
+∞
7.3
7
*
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
6.9
7.3
17
25
WX230
NOMESCO Finland
Plexus blockade of nervus pudendus
4.9
7.3
22
45
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
2.4
7.1
56
235
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
0.3
7.0
14
461
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
2.5
6.9
50
203
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
4.7
6.7
21
45
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
6.7
1065
9517
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.7
6.4
125
750
45499
ICD-8 Finland
Varicose veins of lower extremities, Other and unspecified, without ulcer
2.0
6.3
78
406
O71.4
ICD-10 Finland
Obstetric high vaginal laceration
+∞
6.3
6
*
65220
ICD-8 Finland
Occipital presentation
+∞
6.3
6
*
O62.0
ICD-10 Finland
Primary inadequate contractions
+∞
6.3
6
*
O66.5
ICD-10 Finland
Failed application of vacuum extractor and forceps, unspecified
+∞
6.3
6
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.1
1178
10732
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
2.5
6.1
44
178
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.5
6.1
192
1313
LEF00
NOMESCO Finland
Anterior colporraphy with sutures for primary cystocele
1.9
6.0
82
441

Mortality – FinRegistry

Association

Association between endpoint O15_LABOUR_INTRAPART_HAEMORRH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_INTRAPART_HAEMORRH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_LABOUR_INTRAPART_HAEMORRH – Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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