Complications of the puerperium, not elsewhere classified

O15_PUERP_COMPL_NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O90
  • Hospital discharge: ICD-9 674
  • Cause of death: ICD-10 O90
  • Cause of death: ICD-9 674

2 out of 7 registries used, show all original rules.

1649

4. Check minimum number of events

None

1649

5. Include endpoints

None

1649

6. Filter based on genotype QC (FinnGen only)

1649

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O85-O92
Name in latin
Complicationes puerperii non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10798 10798 -
Only index persons 10636 10636 -
Unadjusted period prevalence (%)
Whole population 0.31 0.31 -
Only index persons 0.39 0.39 -
Median age at first event (years)
Whole population - 29.96 -
Only index persons - 29.94 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1649 1649 -
Unadjusted period prevalence (%) 0.56 0.56 -
Median age at first event (years) 30.56 30.56 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1439
Matched controls
14389
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O90.9
ICD-10 Finland
Complication of the puerperium, unspecified
+∞
286.3
265
*
6748X
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Other
+∞
275.0
255
*
O90.1
ICD-10 Finland
Disruption of perineal obstetric wound
525.8
231.0
224
5
O90.8
ICD-10 Finland
Other complications of the puerperium, not elsewhere classified
2134.2
208.5
197
*
O90.2
ICD-10 Finland
Haematoma of obstetric wound
+∞
168.1
158
*
O90.0
ICD-10 Finland
Disruption of caesarean section wound
+∞
134.5
127
*
6749X
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Unspecified
+∞
84.2
80
*
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
81.1
75.0
84
11
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
2.7
69.2
818
4735
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
3.1
63.8
450
1865
6743A
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Other complications of obstetrical surgical wounds
+∞
59.8
57
*
O90.5
ICD-10 Finland
Postpartum thyroiditis
+∞
57.7
55
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.6
55.0
568
2920
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.5
52.2
577
3054
MWA00
NOMESCO Finland
Repair of wound dehiscence in obstetric surgery
64.6
48.6
56
9
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
3.1
41.1
257
947
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.3
40.9
481
2552
ZXD05
NOMESCO Finland
Urgent procedure
2.2
39.9
585
3431
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
6.9
39.1
101
156
O99.80
ICD-10 Finland
The fear of childbirth
3.3
39.1
215
720
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.6
39.0
336
1505
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
140.5
38.9
41
*
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.6
38.2
325
1445
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
2.8
35.0
255
1028
O85
ICD-10 Finland
Puerperal sepsis
97.5
34.9
38
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
2.4
32.9
326
1560
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.4
32.5
314
1480
8841
FHL
Uterine emptying and scraping (ad 6 weeks)
16.3
32.2
52
33
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
2.8
30.7
226
912
MWE00
NOMESCO Finland
Reoperation for deep haemorrhage in obstetric surgery
36.4
30.7
39
11
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.3
30.5
349
1783
Z37.0
ICD-10 Finland
Single live birth
2.2
29.4
345
1779
6742A
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Disruption of perineal wound
+∞
29.3
28
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.0
28.3
474
2836
W78
ICPC
Pregnancy
2.0
27.2
476
2886
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
5.1
26.2
85
175
ZXE00
NOMESCO Finland
One hour or less
1.8
25.9
629
4267
XMA22
NOMESCO Finland
General examination of pregnant woman
2.5
25.6
219
959
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.2
25.3
293
1489
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.0
25.1
416
2455
SPAT1197
SPAT
Extensive health check-up of expecting family
2.0
24.6
422
2520
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.1
24.4
345
1911
P01AB01
ATC
metronidazole; oral, rectal
1.8
23.8
670
4730
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
23.1
312
1687
6700A
ICD-9 Finland
Major puerperal infection
+∞
23.0
22
*
Z3232
NOMESCO Finland
Midwife
2.1
22.7
304
1640
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.4
21.9
209
964
O81.4
ICD-10 Finland
Vacuum extractor delivery
2.4
21.4
206
952
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
2.5
20.8
176
761
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
20.5
673
4898
O86.8
ICD-10 Finland
Other specified puerperal infections
+∞
19.8
19
*
R3110
NOMESCO Finland
Psychosocial training
4.3
19.8
74
178
WX320
NOMESCO Finland
Spinalanesthesy
2.0
19.5
306
1744
Z39.1
ICD-10 Finland
Care and examination of lactating mother
3.6
18.4
85
247
O82.0
ICD-10 Finland
Delivery by elective caesarean section
2.4
18.1
160
707
TMA00
NOMESCO Finland
Episiotomy
2.7
17.7
130
519
MA3AE
NOMESCO Finland
Combined first trimester screening
2.5
17.7
148
634
MAE00
NOMESCO Finland
Outlet vacuum delivery
2.3
17.1
171
804
SPAT1379
SPAT
Health check-up of pregnant person
1.8
17.0
344
2130
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
16.7
513
3602
MBA04
NOMESCO Finland
Curettage of uterus after delivery
6.9
16.6
41
61
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
1.8
16.4
326
2004
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
2.4
16.3
149
669
MBC40
NOMESCO Finland
Revision of paravaginal or vulvar haematoma after delivery or abortion
24.8
16.0
22
9
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
2.3
15.6
151
696
J01DB01
ATC
cefalexin; oral
1.7
15.4
1184
10456
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
+∞
14.6
14
*
SPAT1380
SPAT
Postpartum check-up
1.8
14.2
289
1785
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.8
14.0
254
1507
W92
ICPC
Compl labour/ delivery livebirth
3.0
13.7
78
266
W85
ICPC
Gestational diabetes
2.3
13.6
129
590
WX307
NOMESCO Finland
Obstetric epidural analgesia
1.8
13.5
246
1459
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
13.5
441
3107
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.9
13.0
204
1150
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
13.0
554
4158
8842
FHL
Peritoneal and vaginal wound revision
131.1
12.5
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
12.3
443
3180
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
3.1
12.3
66
217
Z2221
NOMESCO Finland
Medical doctor
1.6
12.3
430
3065
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
3.0
12.1
71
248
MAA00
NOMESCO Finland
Amniocentesis
2.8
11.9
75
274
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
2.4
11.8
103
450
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
2.5
11.5
93
394
O32.1
ICD-10 Finland
Maternal care for breech presentation
2.1
11.4
134
673
O73.1
ICD-10 Finland
Retained portions of placenta and membranes, without haemorrhage
4.9
11.3
36
75
B01AB05
ATC
enoxaparin; parenteral
1.6
11.3
322
2173
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
2.3
11.0
108
500
MAC96
NOMESCO Finland
Other induction or advancement of labour
2.5
10.9
89
376
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
2.8
10.7
67
244
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
10.7
220
1354
MWW96
NOMESCO Finland
Other reoperation in obstetric surgery
60.4
10.6
12
*
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
2.8
10.5
68
254
WX322
NOMESCO Finland
Combined spinal-epidural analgesia in obstetrics
2.9
10.4
61
215
OAA11
SPAT
NA
2.4
10.3
85
364
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.0
10.2
138
737
J01DA01
ATC
[U] cefalexin; systemic
1.4
9.8
894
7674
O72.0
ICD-10 Finland
Third-stage haemorrhage
2.6
9.7
70
280
8811
FHL
Cesarean section
2.0
9.4
124
655
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
9.2
92
433
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.7
9.0
58
218
MAX99
NOMESCO Finland
Assistance to normal delivery
1.6
8.9
263
1783
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
2.3
8.9
79
352
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
3.0
8.8
50
171
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
3.0
8.7
47
158
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
2.2
8.6
85
397
O02.1
ICD-10 Finland
Missed abortion
1.8
8.6
142
812
W84
ICPC
Pregnancy high risk
2.0
8.6
107
552
R2110
NOMESCO Finland
Giving the first information
1.9
8.6
134
751
8831
FHL
Uterine exploration and / or scraping or suction emptying (ad 24 hours)
6.0
8.5
22
37
O61.0
ICD-10 Finland
Failed medical induction of labour
3.5
8.4
38
112
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
2.2
8.2
82
384
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
1.9
8.1
112
603
O92.7
ICD-10 Finland
Other and unspecified disorders of lactation
33.5
8.1
10
*
OAA12
SPAT
NA
2.8
8.1
51
188
6660A
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM STADII III]
3.9
7.8
30
78
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.7
1144
10470
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.1
7.7
85
418
O14.1
ICD-10 Finland
Severe pre-eclampsia
3.5
7.6
34
100
Z71.8
ICD-10 Finland
Other specified counselling
1.4
7.6
356
2662
J02AC01
ATC
fluconazole; systemic
1.4
7.6
742
6311
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.3
7.5
70
319
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
2.8
7.5
46
169
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
4.1
7.5
27
66
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
7.3
372
2825
O90.3
ICD-10 Finland
Cardiomyopathy in the puerperium
+∞
7.3
7
*
8849
FHL
Other measure in this category
+∞
7.3
7
*
W05
ICPC
Pregnancy vomiting/nausea
3.5
7.2
32
94
Z30.2
ICD-10 Finland
Sterilization
1.6
7.2
219
1490
6660C
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC PARTIALI]
6.1
7.1
18
30
WX600
NOMESCO Finland
Single shot through catheter
2.6
7.0
49
193
8801
FHL
Suction cup delivery
2.6
7.0
49
193
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.1
7.0
72
347
O80.0
ICD-10 Finland
Spontaneous vertex delivery
1.3
6.8
668
5648
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
2.4
6.8
57
247
6611B
ICD-9 Finland
Abnormality of forces of labour, Secondary uterine inertia
3.2
6.7
32
100
J01
ICD-10 Finland
Acute sinusitis
2.0
6.7
85
445
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
1.8
6.7
108
616
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.8
6.6
40
147
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
2.2
6.5
63
293
Z3226
NOMESCO Finland
Physiotherapist
1.5
6.5
200
1365
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.4
6.5
52
221
OAA10
SPAT
NA
2.5
6.5
47
192
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
2.2
6.4
58
264
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.9
6.4
86
459
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.3
125
762
Z39.0
ICD-10 Finland
Care and examination immediately after delivery
2.9
6.3
36
126
O86.2
ICD-10 Finland
Urinary tract infection following delivery
+∞
6.3
6
*
6741A
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Disruption of Caesarean wound
+∞
6.3
6
*
6744A
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Placental polyp
+∞
6.3
6
*
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
2.4
6.2
49
209
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
2.1
6.2
66
321
M01AE01
ATC
ibuprofen; systemic, rectal
1.6
6.2
1323
12604
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.2
425
3381
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
2.3
6.2
53
233
O75.0
ICD-10 Finland
Maternal distress during labour and delivery
2.7
6.2
38
142
SPAT1195
SPAT
Antenatal classes
1.9
6.1
86
467
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
1.7
6.1
111
659
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
2.2
6.0
57
263

Mortality – FinRegistry

Association

Association between endpoint O15_PUERP_COMPL_NAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PUERP_COMPL_NAS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_PUERP_COMPL_NAS – Complications of the puerperium, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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