No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D09
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ, bladder
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ, bladder
- Carcinoma in situ of other and unspecified sites
- Carcinoma in situ of other and unspecified sites
- In situ neoplasms
- In situ neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4595 | 913 | 3669 |
| Only index persons | 4430 | 880 | 3550 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.03 | 0.10 |
| Only index persons | 0.12 | 0.03 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 72.42 | 72.37 | 72.44 |
| Only index persons | 72.33 | 72.15 | 72.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1071 | 200 | 871 |
| Unadjusted period prevalence (%) | 0.33 | 0.07 | 0.38 |
| Median age at first event (years) | 71.53 | 68.62 | 72.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 990
- Matched controls
- 9900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
682.8
323.0
577
20
8130/2-C67.9
ICD-O-3
Papillary urothelial carcinoma, non-invasive of bladder, NOS
+∞
323.0
711
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
323.0
406
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
3253.8
323.0
493
*
KCD02
NOMESCO Finland
Transurethral resection of bladder
1312.9
323.0
660
15
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
323.0
634
*
UKC02
NOMESCO Finland
Cystoscopy
367.1
323.0
971
1198
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
316.0
286
*
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
211.4
298.2
297
20
R31
ICD-10 Finland
Unspecified haematuria
16.4
293.4
551
703
C61
ICD-10 Finland
Malignant neoplasm of prostate
364.8
182.7
179
6
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
2096.3
178.7
168
*
ZX136
NOMESCO Finland
Intravesicalis
191.3
170.7
174
11
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
129.7
154.4
163
15
8120/2-C67.9
ICD-O-3
Urothelial carcinoma in situ of bladder, NOS
+∞
138.8
130
*
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
51.4
123.9
149
34
WX320
NOMESCO Finland
Spinalanesthesy
5.0
108.6
464
1487
XKD00
NOMESCO Finland
Uroflowmetry
5.0
106.8
446
1388
130
Kela drug reimbursment
Malignant tumour
+∞
100.7
95
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.0
93.4
371
1062
116
Kela drug reimbursment
Prostate cancer
+∞
85.7
81
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
84.9
411
1407
8130/2-C67.2
ICD-O-3
Papillary urothelial carcinoma, non-invasive of lateral wall of bladder
+∞
82.4
78
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.1
72.1
192
325
TKW99
NOMESCO Finland
Other minor surgical procedure in urology
62.8
69.9
81
14
U06
ICPC
Haematuria
14.3
69.4
121
95
TKC20
NOMESCO Finland
Catheterisation of bladder
5.9
67.4
207
421
WC305
NOMESCO Finland
Simple therapy of local tumor recidive with biomodifiers
692.3
66.7
65
*
KCW96
NOMESCO Finland
Other operations on bladder
57.8
63.9
75
14
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
31.4
60.8
81
28
L02AE02
ATC
leuprorelin; implant, parenteral
208.7
57.7
59
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
148.1
53.4
56
*
JN4AD
NOMESCO Finland
Body CT examination
7.8
52.4
127
183
WX402
NOMESCO Finland
General anaesthesia
4.2
52.2
225
645
WF002
NOMESCO Finland
Radical radiotherapy
98.8
51.4
56
6
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
61.4
50.0
58
10
C67
ICD-10 Finland
Malignant neoplasm of bladder
+∞
49.4
47
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
48.3
46
*
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
+∞
48.3
46
*
A04AA02
ATC
granisetron; systemic, transdermal
175.2
48.3
50
*
WX224
NOMESCO Finland
Blockade of obturius nerve
+∞
47.2
45
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
167.8
46.2
48
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.5
45.9
247
848
J01MA02
ATC
ciprofloxacin; systemic
2.6
45.6
505
2790
JN4BD
NOMESCO Finland
Extensive body CT
5.7
44.4
136
268
ZXC20
NOMESCO Finland
Use of chemical agents
14.9
44.3
75
54
H02AB02
ATC
dexamethasone; systemic
19.1
44.2
68
38
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
43.0
41
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.4
42.9
172
453
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
42.0
40
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.5
39.1
206
686
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
39.1
317
1423
KH1AD
NOMESCO Finland
CT of urinary organs
7.3
39.0
97
144
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
109.5
39.0
42
*
L02BB03
ATC
bicalutamide; oral
+∞
38.8
37
*
UKB02
NOMESCO Finland
Retrograde ureteroscopy
15.5
38.5
64
44
WF049
NOMESCO Finland
Radiotherapy of metastasis
391.6
38.3
38
*
KBJ10
NOMESCO Finland
Cutaneous ureteroenterostomy
391.6
38.3
38
*
4CX01
NOMESCO Finland
NA
+∞
37.7
36
*
ZXE00
NOMESCO Finland
One hour or less
2.4
37.0
444
2470
N30.0
ICD-10 Finland
Acute cystitis
3.8
36.0
169
509
D41.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Renal pelvis
+∞
35.6
34
*
D09.0
ICD-10 Finland
Carcinoma in situ: Bladder
+∞
35.6
34
*
Y77
ICPC
Malignant neoplasm prostate
98.6
34.9
38
*
KCC10
NOMESCO Finland
Cystoprostatectomy
348.3
34.1
34
*
ZXC15
NOMESCO Finland
Use of photodynamic technique
19.8
33.8
51
27
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
9.1
33.1
71
83
WZC30
NOMESCO Finland
Teaching
3.7
32.5
157
482
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
+∞
32.5
31
*
KCW02
NOMESCO Finland
Lavation of bladder for coagulated blood
14.5
32.4
55
40
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
+∞
31.4
30
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.0
30.4
102
221
C66
ICD-10 Finland
Malignant neoplasm of ureter
+∞
30.4
29
*
KC1GB
NOMESCO Finland
Cystography with X-ray
159.7
29.8
31
*
U76
ICPC
Malignant neoplasm of bladder
+∞
29.3
28
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
28.2
27
*
G04BD12
ATC
mirabegron; oral
3.1
28.1
168
604
KED22
NOMESCO Finland
Transurethral resection of prostate
3.2
27.8
161
566
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
12.2
27.4
50
43
KCB00
NOMESCO Finland
Biopsy of bladder
55.0
27.3
32
6
JN4CD
NOMESCO Finland
Very extensive body CT
8.4
27.2
61
77
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
27.2
26
*
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
5.7
27.2
81
153
N02BE01
ATC
paracetamol; systemic, rectal
2.5
27.1
846
6912
R33
ICD-10 Finland
Retention of urine
3.0
26.4
173
659
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
95.9
25.8
28
*
115
Kela drug reimbursment
Breast cancer
+∞
25.1
24
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
24.9
389
2325
C67.4
ICD-10 Finland
Malignant neoplasm: Posterior wall of bladder
256.1
24.8
25
*
G04CA02
ATC
tamsulosin; oral
2.0
24.7
444
2810
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
33.0
24.7
32
10
Z51.5
ICD-10 Finland
Palliative care
6.8
24.5
63
98
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
24.0
23
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
24.0
23
*
J01MA12
ATC
levofloxacin; systemic
2.4
23.8
234
1122
A04AA01
ATC
ondansetron; systemic, rectal
10.7
23.7
46
45
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
245.5
23.7
24
*
A98
ICPC
Health maint/preventive medicine
3.2
23.7
926
8106
8130/2-C67.6
ICD-O-3
Papillary urothelial carcinoma, non-invasive of ureteric orifice
+∞
23.0
22
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
85.4
22.7
25
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
41.1
22.7
28
7
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.2
22.7
51
65
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
22.7
187
815
KA1AE
NOMESCO Finland
Kidney ultrasound examination
7.4
22.4
54
77
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.8
22.0
76
170
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
21.9
21
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
21.9
490
3325
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
224.6
21.7
22
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.8
21.6
55
85
NK6AN
NOMESCO Finland
Total body bone isotope imaging
51.2
21.2
25
5
C67.1
ICD-10 Finland
Malignant neoplasm: Dome of bladder
+∞
20.9
20
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
20.9
20
*
KH1DD
NOMESCO Finland
CT urography of urinary organs
78.5
20.7
23
*
KDV10
NOMESCO Finland
Internal urethrotomy
7.5
20.7
49
68
J01EA01
ATC
trimethoprim; systemic
2.3
20.4
209
1015
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
20.0
106
346
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
203.7
19.6
20
*
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
32.0
19.3
25
8
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
18.8
18
*
L01BC06
ATC
capecitabine; oral
+∞
18.8
18
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
18.8
18
*
C65
ICD-10 Finland
Malignant neoplasm of renal pelvis
+∞
18.8
18
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
18.8
18
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
18.8
18
*
R82.8
ICD-10 Finland
Abnormal findings on cytological and histological examination of urine
101.9
18.6
20
*
B02AA02
ATC
tranexamic acid; systemic
3.2
18.5
103
346
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
18.1
381
2475
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
8.4
17.8
39
48
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
17.8
17
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
17.8
17
*
J01DB01
ATC
cefalexin; oral
1.9
17.7
761
6259
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
96.7
17.6
19
*
L02BG04
ATC
letrozole; oral
96.7
17.6
19
*
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
9.3
17.5
36
40
B01AB05
ATC
enoxaparin; parenteral
1.9
16.9
290
1739
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
16.7
16
*
C67.5
ICD-10 Finland
Malignant neoplasm: Bladder neck
+∞
16.7
16
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
16.7
16
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
16.7
16
*
8130/2-C67.4
ICD-O-3
Papillary urothelial carcinoma, non-invasive of posterior wall of bladder
+∞
16.7
16
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
91.6
16.6
18
*
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
7.1
16.5
40
58
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.2
16.1
62
155
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.6
15.9
73
213
SPAT1167
SPAT
Insertion of urinary catheter
3.8
15.7
68
189
KBH20
NOMESCO Finland
Replantation of ureter
+∞
15.7
15
*
KBV10
NOMESCO Finland
Removal of stent from ureter
22.4
15.6
22
10
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
15.4
128
554
KA3EB
NOMESCO Finland
Antegrade pyelography
57.5
14.8
17
*
B01AB10
ATC
tinzaparin; parenteral
3.6
14.8
67
194
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.4
14.8
54
129
KCD30
NOMESCO Finland
Destruction of tumour of bladder
+∞
14.6
14
*
KDE20
NOMESCO Finland
Removal of foreign body from urethra
14.4
14.6
24
17
L03AA13
ATC
pegfilgrastim; parenteral
152.0
14.5
15
*
SPAT1263
SPAT
Sampling
1.7
14.1
413
2915
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.2
14.0
155
772
A02BC02
ATC
pantoprazole; systemic
1.7
14.0
603
4749
KH1FT
NOMESCO Finland
Exchange of urinary catheter with radiological guidance
54.1
13.8
16
*
C67.3
ICD-10 Finland
Malignant neoplasm: Anterior wall of bladder
+∞
13.6
13
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
13.6
13
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
13.6
13
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
13.6
13
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
13.6
13
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
13.6
13
*
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
141.7
13.5
14
*
D41.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Ureter
141.7
13.5
14
*
WX110
NOMESCO Finland
Local anesthesy
1.7
13.3
578
4532
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.7
13.1
44
97
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
50.6
12.9
15
*
ZXC96
NOMESCO Finland
Robot assisted procedure
14.3
12.8
21
15
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
12.5
12
*
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
+∞
12.5
12
*
KAC21
NOMESCO Finland
Percutaneous endoscopic nephroureterectomy
+∞
12.5
12
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
12.5
12
*
KBD00
NOMESCO Finland
Partial excision of ureter
+∞
12.5
12
*
PJD44
NOMESCO Finland
Excision of iliac lymph nodes
+∞
12.5
12
*
8120/2-C67.2
ICD-O-3
Urothelial carcinoma in situ of lateral wall of bladder
+∞
12.5
12
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
12.5
12
*
KA1FN
NOMESCO Finland
Isotope renography
27.0
12.1
16
6
SPAT1312
SPAT
General health counselling
1.7
12.0
293
1939
TKE00
NOMESCO Finland
Needle biopsy of prostate
3.4
12.0
58
178
Z3231
NOMESCO Finland
Registered nurse
1.8
11.9
268
1728
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
47.2
11.9
14
*
SPAT1262
SPAT
Handing over of treatment supplies
1.8
11.9
221
1340
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.6
11.7
87
354
HAB40
NOMESCO Finland
Wedge excision of mammary gland
30.4
11.7
15
5
G04BE03
ATC
sildenafil; oral
12.7
11.7
20
16
TJF80
NOMESCO Finland
Ostomy education
23.2
11.6
16
7
SPAT1153
SPAT
Removal of sutures
1.7
11.6
320
2190
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
11.5
11
*
163
Kela drug reimbursment
Abiraterone and enzalutamide
+∞
11.5
11
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
11.5
11
*
C67.6
ICD-10 Finland
Malignant neoplasm: Ureteric orifice
+∞
11.5
11
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
121.3
11.4
12
*
ZX080
NOMESCO Finland
Image guided radiotherapy
121.3
11.4
12
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
11.4
209
1258
N30.9
ICD-10 Finland
Cystitis, unspecified
3.2
11.3
59
192
KBV00
NOMESCO Finland
Insertion of stent into ureter
20.3
11.1
16
8
G04CA01
ATC
alfuzosin; oral
1.8
11.1
207
1253
S18
ICPC
Laceration/cut
1.6
11.1
416
3082
D30.3
ICD-10 Finland
Benign neoplasm: Bladder
43.8
10.9
13
*
WW500
NOMESCO Finland
Blood transfusion
4.6
10.9
37
83
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
10.8
420
3132
KCV22
NOMESCO Finland
Transluminal endoscopic evacuation of blood clots from bladder
28.3
10.7
14
5
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
28.3
10.7
14
5
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
10.7
105
490
U29
ICPC
Urinary symptom/complaint other
3.9
10.6
42
110
U07
ICPC
Urine symptom/complaint other
2.7
10.5
74
292
TKC22
NOMESCO Finland
Catheterisation instruction
4.1
10.5
40
101
XJH00
NOMESCO Finland
Transanal ultrasonography
2.3
10.5
99
456
R39.1
ICD-10 Finland
Other difficulties with micturition
3.3
10.4
52
164
8140/3-C18.2
ICD-O-3
Adenocarcinoma, NOS, of ascending colon
+∞
10.4
10
*
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
+∞
10.4
10
*
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
10.4
10
*
KAC20
NOMESCO Finland
Nephroureterectomy
+∞
10.4
10
*
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
+∞
10.4
10
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
10.4
10
*
8140/3-C34.1
ICD-O-3
Adenocarcinoma, NOS, of upper lobe, lung
+∞
10.4
10
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
10.4
10
*
N02AA05
ATC
oxycodone; systemic
2.1
10.4
121
614
ZX120
NOMESCO Finland
Intravenous
2.5
10.1
83
355
L57.0
ICD-10 Finland
Actinic keratosis
2.3
10.0
93
424
L03AA02
ATC
filgrastim; parenteral
20.2
9.8
14
7
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
55.5
9.7
11
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
9.4
9
*
L02BX02
ATC
degarelix; parenteral
+∞
9.4
9
*
L02BX03
ATC
abiraterone; oral
+∞
9.4
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
9.4
9
*
8130/2-C67.8
ICD-O-3
Papillary urothelial carcinoma, non-invasive of overlapping lesion of bladder
+∞
9.4
9
*
C18.00
ICD-10 Finland
Malignant tumor of the caecum without histology
+∞
9.4
9
*
C18.01
ICD-10 Finland
Malignant tumor of the caecum invasive carcinoma
+∞
9.4
9
*
Z08.2
ICD-10 Finland
Follow-up examination after chemotherapy for malignant neoplasm
+∞
9.4
9
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
9.4
73
306
N40
ICD-10 Finland
Hyperplasia of prostate
1.6
9.3
372
2766
U05
ICPC
Urination problems other
2.6
9.2
68
275
N35.9
ICD-10 Finland
Urethral stricture, unspecified
5.7
9.1
25
45
L02BA01
ATC
tamoxifen; oral
37.0
9.0
11
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.9
235
1566
SPAT1125
SPAT
Stoma care and guidance
5.5
8.9
25
46
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
50.4
8.7
10
*
G04BD08
ATC
solifenacin; oral
2.2
8.7
83
387
R93.4
ICD-10 Finland
Abnormal findings on diagnostic imaging of urinary organs
10.1
8.5
16
16
G03HA01
ATC
cyproterone; systemic
27.7
8.5
11
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
8.3
8
*
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
8.3
8
*
8090/3-C44.2
ICD-O-3
Basal cell carcinoma, NOS, of external ear
+∞
8.3
8
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
8.3
8
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
8.3
8
*
TKC00
NOMESCO Finland
Needle biopsy of bladder
+∞
8.3
8
*
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
+∞
8.3
8
*
L02AE04
ATC
triptorelin; parenteral
+∞
8.3
8
*
A04AD12
ATC
aprepitant; systemic
+∞
8.3
8
*
L02BB04
ATC
enzalutamide; oral
+∞
8.3
8
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
8.3
8
*
R86.0
ICD-10 Finland
Abnormal findings in specimens from male genital organs, abnormal level of enzymes
4.7
8.3
27
59
ZX112
NOMESCO Finland
Subcutaneous
9.5
8.3
16
17
KBV15
NOMESCO Finland
Cystoscopic change of ureteral stent
14.6
8.2
13
9
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.2
8.1
29
70
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
8.1
116
639
GD1AD
NOMESCO Finland
Thorax CT examination
2.8
8.0
48
174
WX400
NOMESCO Finland
Inhalation anesthesy
3.6
8.0
34
96
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
7.9
327
2430
TQW99
NOMESCO Finland
Other minor procedure on skin
3.0
7.9
43
147
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
7.9
99
519
Z71.8
ICD-10 Finland
Other specified counselling
1.7
7.8
180
1154
U01
ICPC
Dysuria/painful urination
2.6
7.8
55
220
A79
ICPC
Malignancy NOS
45.3
7.7
9
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
45.3
7.7
9
*
UKD02
NOMESCO Finland
Urethroscopy
10.1
7.5
14
14
KBB00
NOMESCO Finland
Biopsy of ureter
80.6
7.4
8
*
N21.0
ICD-10 Finland
Calculus in bladder
4.4
7.4
25
58
C34.31
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung epidermoid carcinoma
+∞
7.3
7
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
7.3
7
*
KCC20
NOMESCO Finland
Cystoprostatourethrectomy
+∞
7.3
7
*
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
+∞
7.3
7
*
352
Kela drug reimbursment
Abiraterone and enzalutamide
+∞
7.3
7
*
L01CA04
ATC
vinorelbine; systemic
+∞
7.3
7
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
7.3
7
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
7.3
7
*
KBJ60
NOMESCO Finland
Anastomosis of ureter to urethra with interposition of ileum
+∞
7.3
7
*
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
+∞
7.3
7
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
7.3
7
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
7.3
7
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
7.3
7
*
WX702
NOMESCO Finland
Supraglottic ventilation device
2.6
7.3
50
196
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
7.2
311
2317
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.4
7.2
24
55
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
2.7
7.1
47
182
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.1
7.1
18
30
U02
ICPC
Urinary frequency/urgency
1.9
7.1
102
561
HA1AA
NOMESCO Finland
X-ray mammography
4.8
7.0
22
47
U99
ICPC
Urinary disease other
7.0
7.0
16
23
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
4.1
6.9
25
62
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
4.8
6.9
21
44
KGH10
NOMESCO Finland
Operation for phimosis
2.8
6.8
42
156
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.8
147
927
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.7
296
2214
S77
ICPC
Malignant neoplasm of skin
22.7
6.7
9
*
J01CA04
ATC
amoxicillin; systemic
1.4
6.6
668
5845
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.6
113
662
ZXC50
NOMESCO Finland
Cryotherapy
3.4
6.6
30
91
Z2221
NOMESCO Finland
Medical doctor
1.5
6.6
226
1601
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
8.8
6.6
13
15
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.5
383
3029
NK6BQ
NOMESCO Finland
Whole body extensive bone SPET with low dose CT
70.2
6.4
7
*
KH1YT
NOMESCO Finland
Percutaneous implantation of endoprothesis with radiological guidance
70.2
6.4
7
*
C50.99
ICD-10 Finland
Breast, unspecified
70.2
6.4
7
*
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
70.2
6.4
7
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
4.7
6.4
20
43
WX704
NOMESCO Finland
Intubation
2.2
6.4
62
291
KE1BG
NOMESCO Finland
MRI of prostate
14.4
6.4
10
7
WX600
NOMESCO Finland
Single shot through catheter
14.4
6.4
10
7
SPAT1260
SPAT
Consultation of another employee
1.6
6.4
166
1098
WX882
NOMESCO Finland
High dependency care
3.2
6.4
31
99
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
6.3
93
517
RD211
NOMESCO Finland
NA
2.5
6.3
46
189
A06AH03
ATC
naloxegol; oral
11.1
6.3
11
10
UJF32
NOMESCO Finland
Coloscopy
1.5
6.3
229
1641
WX290
NOMESCO Finland
Other blockade of nerve
1.5
6.3
286
2151
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
8130/2-C67.5
ICD-O-3
Papillary urothelial carcinoma, non-invasive of bladder neck
+∞
6.3
6
*
8070/3-C34.3
ICD-O-3
Squamous cell carcinoma, NOS, of lower lobe, lung
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
6.3
6
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
6.3
6
*
7323
FHL
Electrosection of TU bladder wall change
+∞
6.3
6
*
C18.21
ICD-10 Finland
Malignant tumor of the ascending colon invasive carcinoma
+∞
6.3
6
*
4078
NOMESCO Finland
NA
+∞
6.3
6
*
SPAT1301
SPAT
No procedures
1.5
6.3
298
2259
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.6
6.2
44
176
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.2
433
3525
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
6.2
121
738
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.1
127
787
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
6.1
31
102
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
6.1
236
1712
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
6.1
73
376
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_BLADDER_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_BLADDER_EXALLC | 1.104 [0.82, 1.49] | 0.513 |
| Birth year | 0.999 [0.99, 1.01] | 0.751 |
During the follow-up period (1.1.1998 — 31.12.2019), 123 out of 763 females with CD2_INSITU_BLADDER_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_BLADDER_EXALLC | 0.965 [0.79, 1.18] | 0.735 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 3037 males with CD2_INSITU_BLADDER_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have CD2_INSITU_BLADDER_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.173% |
| 5 | 0.776% | 0.998% |
| 10 | 1.886% | 2.552% |
| 15 | 3.643% | 4.903% |
| 20 | 6.21% | 8.331% |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BLADDER_EXALLC – Carcinoma in situ, bladder
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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