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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_BLADDER_EXALLC for full statistics.

Carcinoma in situ, bladder

CD2_INSITU_BLADDER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_BLADDER
517355

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D09.0&
  • Hospital discharge: ICD-9 2337
  • Cause of death: ICD-10 D09.0&
  • Cause of death: ICD-9 2337
  • Cancer registry: Topography ICD-O-3 C67
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

1071

4. Check minimum number of events

None

1071

5. Include endpoints

None

1071

6. Filter based on genotype QC (FinnGen only)

1071

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D09

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1071 200 871
Unadjusted period prevalence (%) 0.33 0.07 0.38
Median age at first event (years) 71.53 68.62 72.20

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
990
Matched controls
9898
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
77.4
323.0
406
88
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
131.3
323.0
577
104
8130/2-C67.9
ICD-O-3
Papillary urothelial carcinoma, non-invasive of bladder, NOS
9553.9
323.0
711
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
139.2
323.0
493
70
KCD02
NOMESCO Finland
Transurethral resection of bladder
126.9
323.0
660
153
UKC02
NOMESCO Finland
Cystoscopy
277.0
323.0
971
1533
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
135.3
323.0
634
128
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
66.7
259.7
297
63
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
70.2
252.0
286
57
R31
ICD-10 Finland
Unspecified haematuria
12.1
247.7
551
927
ZX136
NOMESCO Finland
Intravesicalis
61.8
149.7
174
34
8120/2-C67.9
ICD-O-3
Urothelial carcinoma in situ of bladder, NOS
+∞
138.9
130
*
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
40.4
129.0
163
48
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
27.2
106.7
149
64
WX320
NOMESCO Finland
Spinalanesthesy
4.6
99.6
464
1590
8130/2-C67.2
ICD-O-3
Papillary urothelial carcinoma, non-invasive of lateral wall of bladder
+∞
82.5
78
*
XKD00
NOMESCO Finland
Uroflowmetry
3.5
68.5
446
1881
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.6
63.2
371
1421
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.9
63.0
192
385
U06
ICPC
Haematuria
9.2
55.6
121
147
TKC20
NOMESCO Finland
Catheterisation of bladder
4.7
54.6
207
525
KCW96
NOMESCO Finland
Other operations on bladder
26.9
54.2
75
30
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
19.1
52.4
81
46
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
51.7
411
1898
WC305
NOMESCO Finland
Simple therapy of local tumor recidive with biomodifiers
38.5
51.3
65
18
TKW99
NOMESCO Finland
Other minor surgical procedure in urology
17.5
50.9
81
50
WX224
NOMESCO Finland
Blockade of obturius nerve
156.9
43.1
45
*
C67
ICD-10 Finland
Malignant neoplasm of bladder
82.2
42.2
47
6
UKB02
NOMESCO Finland
Retrograde ureteroscopy
15.1
38.2
64
45
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.4
37.8
206
703
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
34.4
35.6
46
14
N30.0
ICD-10 Finland
Acute cystitis
3.6
34.2
169
531
KH1AD
NOMESCO Finland
CT of urinary organs
6.1
34.1
97
173
WX402
NOMESCO Finland
General anaesthesia
2.9
32.6
225
899
4CX01
NOMESCO Finland
NA
74.4
32.1
36
5
J01MA02
ATC
ciprofloxacin; systemic
2.2
31.9
505
3144
D09.0
ICD-10 Finland
Carcinoma in situ: Bladder
117.2
31.9
34
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
7.2
28.6
71
105
ZXC20
NOMESCO Finland
Use of chemical agents
6.5
27.9
75
124
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
27.5
247
1142
ZXE00
NOMESCO Finland
One hour or less
2.1
25.4
444
2792
KCW02
NOMESCO Finland
Lavation of bladder for coagulated blood
7.7
23.5
55
75
C66
ICD-10 Finland
Malignant neoplasm of ureter
37.3
23.1
29
8
8130/2-C67.6
ICD-O-3
Papillary urothelial carcinoma, non-invasive of ureteric orifice
+∞
23.0
22
*
KED22
NOMESCO Finland
Transurethral resection of prostate
2.8
22.8
161
640
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
7.2
22.8
56
82
ZXC15
NOMESCO Finland
Use of photodynamic technique
8.2
22.7
51
65
R33
ICD-10 Finland
Retention of urine
2.7
22.3
173
725
A98
ICPC
Health maint/preventive medicine
3.1
22.2
926
8156
U76
ICPC
Malignant neoplasm of bladder
35.9
22.1
28
8
G04BD12
ATC
mirabegron; oral
2.7
21.9
168
700
KCB00
NOMESCO Finland
Biopsy of bladder
20.6
21.8
32
16
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
21.4
187
839
KBJ10
NOMESCO Finland
Cutaneous ureteroenterostomy
12.3
21.2
38
32
C67.4
ICD-10 Finland
Malignant neoplasm: Posterior wall of bladder
42.6
20.5
25
6
D41.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Renal pelvis
13.5
19.8
34
26
KCC10
NOMESCO Finland
Cystoprostatectomy
12.1
18.9
34
29
G04CA02
ATC
tamsulosin; oral
1.8
18.4
444
3028
KDV10
NOMESCO Finland
Internal urethrotomy
6.1
17.9
49
84
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
12.8
17.7
31
25
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
13.4
17.5
30
23
N02BE01
ATC
paracetamol; systemic, rectal
2.1
17.5
846
7269
KH1DD
NOMESCO Finland
CT urography of urinary organs
29.4
17.5
23
8
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
5.7
17.4
50
91
JN4AD
NOMESCO Finland
Body CT examination
2.7
17.3
127
513
8130/2-C67.4
ICD-O-3
Papillary urothelial carcinoma, non-invasive of posterior wall of bladder
+∞
16.7
16
*
R82.8
ICD-10 Finland
Abnormal findings on cytological and histological examination of urine
40.8
16.4
20
5
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
7.2
16.2
39
56
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
17.1
16.1
25
15
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.7
16.0
54
119
C67.5
ICD-10 Finland
Malignant neoplasm: Bladder neck
81.3
14.6
16
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
14.5
389
2684
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
14.3
106
430
C67.1
ICD-10 Finland
Malignant neoplasm: Dome of bladder
22.6
14.2
20
9
J01MA12
ATC
levofloxacin; systemic
1.9
13.7
234
1386
J01EA01
ATC
trimethoprim; systemic
1.9
13.4
209
1197
WZC30
NOMESCO Finland
Teaching
2.1
13.2
157
803
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
13.1
317
2102
KBH20
NOMESCO Finland
Replantation of ureter
50.7
12.9
15
*
8120/2-C67.2
ICD-O-3
Urothelial carcinoma in situ of lateral wall of bladder
+∞
12.5
12
*
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
6.4
12.5
32
51
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
12.5
490
3714
SPAT1263
SPAT
Sampling
1.7
12.4
413
2992
B02AA02
ATC
tranexamic acid; systemic
2.5
12.4
103
445
J01DB01
ATC
cefalexin; oral
1.7
12.4
761
6510
SPAT1167
SPAT
Insertion of urinary catheter
3.0
11.7
68
238
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
11.7
381
2731
KBV10
NOMESCO Finland
Removal of stent from ureter
9.8
11.3
22
23
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
4.3
11.0
40
96
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
4.6
10.7
36
80
KC1GB
NOMESCO Finland
Cystography with X-ray
5.4
10.6
31
59
C67.6
ICD-10 Finland
Malignant neoplasm: Ureteric orifice
111.1
10.4
11
*
N30.9
ICD-10 Finland
Cystitis, unspecified
3.0
10.4
59
203
C67.3
ICD-10 Finland
Malignant neoplasm: Anterior wall of bladder
32.9
10.3
13
*
D41.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Ureter
23.6
10.3
14
6
SPAT1312
SPAT
General health counselling
1.6
9.9
293
2028
U29
ICPC
Urinary symptom/complaint other
3.7
9.8
42
118
U07
ICPC
Urine symptom/complaint other
2.5
9.5
74
309
KCD30
NOMESCO Finland
Destruction of tumour of bladder
17.7
9.4
14
8
KBD00
NOMESCO Finland
Partial excision of ureter
30.3
9.4
12
*
8130/2-C67.8
ICD-O-3
Papillary urothelial carcinoma, non-invasive of overlapping lesion of bladder
+∞
9.4
9
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
3.5
9.2
41
120
G04CA01
ATC
alfuzosin; oral
1.7
9.1
207
1327
KA3EB
NOMESCO Finland
Antegrade pyelography
10.1
9.0
17
17
WX110
NOMESCO Finland
Local anesthesy
1.5
9.0
578
4771
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
8.8
420
3240
S18
ICPC
Laceration/cut
1.5
8.7
416
3212
R39.1
ICD-10 Finland
Other difficulties with micturition
2.9
8.7
52
188
C65
ICD-10 Finland
Malignant neoplasm of renal pelvis
8.3
8.6
18
22
JN4CD
NOMESCO Finland
Very extensive body CT
2.5
8.3
61
249
KDE20
NOMESCO Finland
Removal of foreign body from urethra
5.2
8.2
24
47
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.3
8.1
73
328
U05
ICPC
Urination problems other
2.4
8.1
68
297
KCV22
NOMESCO Finland
Transluminal endoscopic evacuation of blood clots from bladder
11.8
8.1
14
12
KAC21
NOMESCO Finland
Percutaneous endoscopic nephroureterectomy
17.3
8.1
12
7
SPAT1262
SPAT
Handing over of treatment supplies
1.6
8.1
221
1486
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
2.9
7.9
47
169
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.7
7.8
155
951
KGH10
NOMESCO Finland
Operation for phimosis
3.0
7.8
42
143
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
7.7
311
2298
WX702
NOMESCO Finland
Supraglottic ventilation device
2.7
7.6
50
192
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
7.6
128
746
N40
ICD-10 Finland
Hyperplasia of prostate
1.5
7.6
372
2862
U01
ICPC
Dysuria/painful urination
2.5
7.5
55
224
SPAT1301
SPAT
No procedures
1.5
7.4
298
2198
U02
ICPC
Urinary frequency/urgency
1.9
7.3
102
556
RD211
NOMESCO Finland
NA
2.8
7.2
46
172
KH1FT
NOMESCO Finland
Exchange of urinary catheter with radiological guidance
7.4
7.2
16
22
Z08.2
ICD-10 Finland
Follow-up examination after chemotherapy for malignant neoplasm
30.2
7.2
9
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.5
7.2
54
225
D30.3
ICD-10 Finland
Benign neoplasm: Bladder
10.1
7.0
13
13
G04BD08
ATC
solifenacin; oral
2.0
6.9
83
426
KBV00
NOMESCO Finland
Insertion of stent into ureter
6.8
6.8
16
24
A02BC02
ATC
pantoprazole; systemic
1.4
6.8
603
5164
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.6
6.8
165
1071
JN4BD
NOMESCO Finland
Extensive body CT
1.7
6.8
136
839
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.0
6.5
78
402
KAC20
NOMESCO Finland
Nephroureterectomy
14.4
6.4
10
7
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.3
433
3519
KA1FN
NOMESCO Finland
Isotope renography
6.0
6.3
16
27
Z3231
NOMESCO Finland
Registered nurse
1.5
6.3
268
1987
SPAT1153
SPAT
Removal of sutures
1.4
6.3
320
2459
8130/2-C67.5
ICD-O-3
Papillary urothelial carcinoma, non-invasive of bladder neck
+∞
6.3
6
*
B01AB05
ATC
enoxaparin; parenteral
1.5
6.2
290
2194
C61
ICD-10 Finland
Malignant neoplasm of prostate
1.6
6.1
179
1220
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.1
327
2534
R30.0
ICD-10 Finland
Dysuria
2.8
6.1
36
131
N30
ICD-10 Finland
Cystitis
2.6
6.1
43
173
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.8
6.0
105
620
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
6.0
271
2031

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_BLADDER – Carcinoma in situ, bladder

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).