blood coagulation disease: A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
184 |
4. Check minimum number of eventsNone |
184 |
5. Include endpoints |
940 |
6. Filter based on genotype QC (FinnGen only) |
901 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF2
Chronic Coagulation defects
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6363 | 4116 | 2218 |
| Only index persons | 5866 | 3942 | 1924 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.06 |
| Only index persons | 0.12 | 0.14 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 29.42 | 33.02 | 22.61 |
| Only index persons | 29.70 | 32.84 | 23.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 901 | 679 | 222 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.10 |
| Median age at first event (years) | 38.12 | 36.01 | 44.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 940
- Matched controls
- 9400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
307.7
483
*
D68.8
ICD-10 Finland
Other specified coagulation defects
61.2
307.7
191
39
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
2738.8
307.7
342
*
B02AA02
ATC
tranexamic acid; systemic
8.9
253.2
494
1042
126
Kela drug reimbursment
Chronic coagulation defects
+∞
199.2
184
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
37.6
170.4
107
32
D68.9
ICD-10 Finland
Coagulation defect, unspecified
97.0
168.7
88
10
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
95.5
90
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
38.4
70.9
44
12
B01AA03
ATC
warfarin; systemic
4.1
59.2
195
570
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.2
45.7
100
210
B01AB04
ATC
dalteparin; parenteral
5.2
44.2
96
200
B02BD02
ATC
coagulation factor VIII; parenteral
+∞
42.0
40
*
N02AX02
ATC
tramadol; systemic, rectal
2.5
41.3
457
2576
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
6.0
41.2
76
136
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
8.1
39.9
55
72
2864A
ICD-9 Finland
Coagulation defects, von Willebrand's disease
+∞
39.9
38
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
4.4
38.7
104
258
B01AB05
ATC
enoxaparin; parenteral
2.4
33.8
332
1738
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.9
30.7
168
658
28630
ICD-8 Finland
Coagulation defects, Vascular haemophilia
+∞
30.4
29
*
EBA10
NOMESCO Finland
Operative extraction of tooth
2.6
29.3
202
889
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
6.7
29.2
47
73
R04.0
ICD-10 Finland
Epistaxis
3.7
27.1
92
269
2860A
ICD-9 Finland
Coagulation defects, Congenital factor VIII disorder
+∞
26.2
25
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
26.1
458
2953
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
26.0
422
2642
M362, D66,
ICD-10 Finland
+∞
25.1
24
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.3
25.0
67
165
M01AE01
ATC
ibuprofen; systemic, rectal
0.5
24.1
663
7887
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
24.1
136
538
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
2.6
23.9
161
696
28600
ICD-8 Finland
Coagulation defects, Haemophilia
+∞
23.0
22
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.3
22.4
89
288
R42
ICD-10 Finland
Dizziness and giddiness
2.2
22.0
222
1145
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
21.3
148
648
ZX120
NOMESCO Finland
Intravenous
2.8
20.8
114
443
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.2
20.6
87
292
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
17.8
20.1
31
18
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
20.0
425
2847
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
20.0
276
1598
D67
ICD-10 Finland
Hereditary factor IX deficiency
+∞
19.9
19
*
2BD06, ,
NOMESCO Finland
+∞
19.9
19
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.8
19.3
44
95
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
18.6
382
2517
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
18.2
263
1539
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
17.9
345
2221
N02BE01
ATC
paracetamol; systemic, rectal
2.4
16.3
836
7237
ZXE00
NOMESCO Finland
One hour or less
1.8
16.3
395
2709
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
16.0
205
1144
Z31.5
ICD-10 Finland
Genetic counselling
2.7
15.9
89
349
M79.6
ICD-10 Finland
Pain in limb
1.8
15.6
411
2876
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
15.5
103
439
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
15.2
283
1786
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
3.8
15.0
46
125
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
15.0
422
2999
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.7
14.9
81
312
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
14.8
371
2549
UJF32
NOMESCO Finland
Coloscopy
1.9
14.8
222
1306
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
14.7
324
2147
D68.1
ICD-10 Finland
Hereditary factor XI deficiency
+∞
14.6
14
*
D69.1
ICD-10 Finland
Qualitative platelet defects
81.4
14.6
16
*
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.4
14.5
106
472
D68.4
ICD-10 Finland
Acquired coagulation factor deficiency
152.3
14.5
15
*
N03AX16
ATC
[U] pregabalin
1.9
14.5
219
1290
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
36.7
14.5
18
5
R06.0
ICD-10 Finland
Dyspnoea
1.9
14.4
242
1474
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.8
14.2
26
46
H02AB06
ATC
prednisolone; systemic
1.7
14.1
435
3156
AA1AD
NOMESCO Finland
CT of head and brain
1.9
13.7
209
1233
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
13.6
149
782
M36.2
ICD-10 Finland
Haemophilic arthropathy
+∞
13.6
13
*
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
13.5
252
1581
G43.9
ICD-10 Finland
Migraine, unspecified
2.4
13.5
97
429
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
13.4
257
1626
B18.2
ICD-10 Finland
Chronic viral hepatitis C
5.2
12.7
26
51
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
12.7
186
1079
J01FF01
ATC
clindamycin; systemic
1.8
12.7
256
1640
194
Kela drug reimbursment
Blood coagulation factor VIII and von Willebrand factor for the treatment of von Willebrand disease
+∞
12.5
12
*
B02BX06
ATC
emicizumab; parenteral
+∞
12.5
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
12.5
217
1329
Z3231
NOMESCO Finland
Registered nurse
1.7
12.3
260
1687
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
12.1
347
2443
R51.80
ICD-10 Finland
Headache
1.9
11.8
185
1097
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
11.7
140
757
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
11.6
188
1125
K01.0
ICD-10 Finland
Embedded teeth
3.9
11.5
34
90
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.6
11.5
38
109
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
4.9
11.5
25
52
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
121.4
11.4
12
*
J01MA02
ATC
ciprofloxacin; systemic
1.7
11.4
315
2187
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
11.4
175
1030
J01DB01
ATC
cefalexin; oral
1.9
11.3
785
6872
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
4.7
11.2
26
57
J01DA01
ATC
[U] cefalexin
1.6
11.2
573
4618
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.6
11.2
67
271
K08.3
ICD-10 Finland
Retained dental root
2.5
11.2
70
290
M25.0
ICD-10 Finland
Haemarthrosis
8.7
11.1
23
27
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.5
10.9
71
300
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
10.8
124
661
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
2.8
10.8
53
194
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
10.7
276
1879
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
5.3
10.6
21
40
R4110
NOMESCO Finland
Physiotherapy
1.7
10.5
244
1614
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
10.4
414
3125
B02BD06
ATC
von Willebrand factor and coagulation factor VIII in combination; parenteral, topical, urethral
+∞
10.4
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
10.4
265
1795
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
5.2
10.3
21
41
R03AC02
ATC
salbutamol; inhalant
1.6
10.3
540
4339
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
4.5
10.3
25
57
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.9
10.3
30
79
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
10.2
169
1016
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.2
10.2
92
448
R01AD12
ATC
fluticasone furoate; nasal
1.6
10.1
338
2447
C03CA01
ATC
furosemide; systemic
1.8
10.1
180
1106
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
9.9
67
288
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
9.8
204
1307
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
4.6
9.8
23
51
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.1
9.7
92
456
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
9.7
100
512
K94
ICPC
Phlebitis/thrombophlebitis
4.5
9.6
23
52
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
3.0
9.5
43
150
M25.5
ICD-10 Finland
Pain in joint
1.6
9.5
312
2242
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
9.5
225
1493
I87.0
ICD-10 Finland
Postthrombotic syndrome
17.7
9.4
14
8
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.1
9.4
87
427
J01FA10
ATC
azithromycin; systemic
1.6
9.4
582
4811
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
7.0
9.4
22
32
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
9.3
84
408
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.7
9.2
49
187
Z71.8
ICD-10 Finland
Other specified counselling
1.6
9.2
311
2248
3AC01, ,
NOMESCO Finland
7.8
9.2
20
26
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.5
9.1
59
249
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.2
9.0
35
112
R60.0
ICD-10 Finland
Localized oedema
2.0
9.0
99
519
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.0
9.0
102
541
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.6
9.0
50
196
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
8.8
74
349
P01AB01
ATC
metronidazole; oral, rectal
1.5
8.8
385
2938
SPAT1229
SPAT
Assessment of need for aid
2.4
8.8
60
259
H02AB04
ATC
methylprednisolone; systemic
1.8
8.7
131
762
K92.1
ICD-10 Finland
Melaena
2.8
8.7
43
158
C07AB07
ATC
bisoprolol; oral
1.5
8.7
337
2503
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
8.7
70
325
Z3226
NOMESCO Finland
Physiotherapist
1.7
8.6
167
1047
A07DA03
ATC
loperamide; oral
3.2
8.6
33
105
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
9.1
8.6
17
19
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
8.5
317
2331
ZXD05
NOMESCO Finland
Urgent procedure
1.6
8.5
289
2082
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
8.5
116
655
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
8.4
503
4085
28610
ICD-8 Finland
Coagulation defects, Christmas disease
+∞
8.3
8
*
2BDXX, ,
NOMESCO Finland
+∞
8.3
8
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
8.3
124
719
A46
ICD-10 Finland
Erysipelas
1.9
8.3
103
563
9981A
ICD-9 Finland
Other complications of procedures, not elsewhere classified, Haemorrhage or haematoma complicating a procedure
9.6
8.3
16
17
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
4.1
8.3
22
54
R55
ICD-10 Finland
Syncope and collapse
2.0
8.2
86
442
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
8.2
126
737
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
8.2
53
223
N02BF01
ATC
gabapentin; oral
2.1
8.2
79
394
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
8.2
69
327
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
8.2
112
633
A06AD11
ATC
lactulose; oral
1.9
8.1
99
539
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
9.0
8.1
16
18
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
8.0
172
1106
S06.0
ICD-10 Finland
Concussion
1.9
8.0
105
584
SPAT1263
SPAT
Sampling
1.5
8.0
376
2896
Z83.2
ICD-10 Finland
Family history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
22.2
8.0
11
5
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
8.0
72
350
ZXA10
NOMESCO Finland
Bilateral
1.7
7.8
152
954
N06AX22
ATC
agomelatine; oral
3.0
7.7
33
112
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.7
259
1857
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
7.7
174
1135
N03AX12
ATC
[U] gabapentin; oral
1.7
7.7
145
901
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
7.7
91
490
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.6
524
4342
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.0
7.6
83
435
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
7.5
122
727
J20
ICD-10 Finland
Acute bronchitis
1.9
7.5
98
546
D68
ICD-10 Finland
Other coagulation defects
80.7
7.4
8
*
3A149, ,
NOMESCO Finland
80.7
7.4
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
7.4
103
584
Z2221
NOMESCO Finland
Medical doctor
1.5
7.4
261
1887
I80.20
ICD-10 Finland
Phlebitis and thrombophlebitis in the iliac vein
11.0
7.3
13
12
3047, ,
Kela drug reimbursment
+∞
7.3
7
*
B02BD04
ATC
coagulation factor IX; parenteral
+∞
7.3
7
*
1520, ,
Kela drug reimbursment
+∞
7.3
7
*
2BD02, ,
NOMESCO Finland
+∞
7.3
7
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.3
116
686
UJF30
NOMESCO Finland
Ileoscopy through colon
1.9
7.3
89
484
R52.9
ICD-10 Finland
Pain, unspecified
1.9
7.3
91
499
R31
ICD-10 Finland
Unspecified haematuria
2.1
7.2
66
324
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
30.3
7.2
9
*
K02.9
ICD-10 Finland
Dental caries, unspecified
3.5
7.2
24
70
SAA04
NOMESCO Finland
Special examination of mouth
2.1
7.1
64
311
LCA06
NOMESCO Finland
Biopsy of endometrium
1.7
7.1
125
761
L28
ICPC
Limited function/disability (L)
1.7
7.1
124
754
TLC02
NOMESCO Finland
Simple extraction of IUD
2.3
7.1
55
252
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
7.0
78
411
WX002
NOMESCO Finland
Sedation and analgesia
1.7
7.0
152
980
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.9
7.0
94
528
N02AA05
ATC
oxycodone; systemic
1.8
6.9
116
696
D86.0
ICD-10 Finland
Sarcoidosis of lung
5.5
6.9
19
35
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
6.9
125
767
J45
ICD-10 Finland
Asthma
1.8
6.9
99
568
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
6.9
191
1308
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.2
6.9
59
282
J01AA02
ATC
doxycycline; systemic
1.5
6.9
669
5868
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
2.1
6.8
66
330
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
6.8
131
817
R06AE07
ATC
cetirizine; oral
1.4
6.8
421
3390
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.7
6.8
35
132
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
6.8
107
631
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.5
6.8
42
174
A02BC02
ATC
pantoprazole; systemic
1.4
6.8
564
4795
J01FA06
ATC
roxithromycin; oral
1.5
6.7
344
2675
K99
ICPC
Cardiovascular disease other
4.1
6.6
18
45
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
2.7
6.6
34
128
R03AC03
ATC
terbutaline; inhalant
1.7
6.6
128
800
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
6.6
160
1060
N02AC04
ATC
dextropropoxyphene; oral
3.0
6.6
28
95
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
6.6
161
1069
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.2
6.6
17
41
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
6.5
98
569
Z01.2
ICD-10 Finland
Dental examination
1.4
6.5
432
3513
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.9
6.5
82
450
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
6.5
66
336
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
6.5
222
1590
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.5
173
1172
M54.5
ICD-10 Finland
Low back pain
1.5
6.5
321
2475
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.3
6.5
24
75
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
6.4
72
381
M79.7
ICD-10 Finland
Fibromyalgia
2.4
6.4
42
179
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
6.3
504
4226
T81.9
ICD-10 Finland
Unspecified complication of procedure
3.6
6.3
20
56
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.3
6.3
47
212
J01CA04
ATC
amoxicillin; systemic
1.6
6.3
777
7074
R52.2
ICD-10 Finland
Other chronic pain
2.5
6.3
39
162
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.2
6.3
53
252
B83
ICPC
Purpura/coagulation defect
+∞
6.3
6
*
O991, D680,
ICD-10 Finland
+∞
6.3
6
*
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
5.1
6.2
18
36
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
6.2
180
1244
M01AH01
ATC
celecoxib; oral
1.6
6.2
134
863
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
6.1
125
792
SPAT1301
SPAT
No procedures
1.5
6.1
253
1881
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
6.1
44
196
J01MA14
ATC
moxifloxacin; systemic
1.9
6.1
71
381
W84
ICPC
Pregnancy high risk
2.2
6.0
47
216
C01CA24
ATC
epinephrine; parenteral
1.9
6.0
78
433
62660
ICD-8 Finland
Disorders of menstruation, Intermenstrual bleeding
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
388
235
27.41
307.65
7.2
3.0
114.03
172.17
%
19.77
366
226
282
235
16.71
295.84
4.5
3.3
3.14
3.55
g/l
3.49
260
222
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
124
26
54.79
216.13
1.6
1.0
100.38
129.42
%
2.39
112
26
432
973
7.37
201.28
4.4
2.2
32.50
29.59
s
5.24
414
940
109
26
47.29
184.16
1.3
1.0
93.66
98.94
%
0.26
58
16
108
27
45.06
180.38
1.3
1.0
95.15
94.59
%
0.03
55
17
212
270
9.85
162.30
5.3
2.9
96.19
94.09
%
0.61
207
257
98
8
136.54
92.95
1.7
1.6
—
—
—
0
0
448
1808
3.82
88.94
7.2
3.6
93.18
94.79
%
0.54
431
1751
307
1056
3.83
75.39
5.0
3.8
0.82
0.82
mmol/l
0.64
299
1001
410
1766
3.34
69.88
3.7
1.9
0.75
0.93
mg/l
1.20
301
1314
524
2807
2.96
57.98
21.9
10.4
1.29
1.16
inr
2.76
181
885
182
566
3.75
50.06
3.0
2.3
83.93
74.25
ml/min/173m2
3.09
137
221
47
0
+∞
49.41
1.5
0.0
50.88
—
%
—
41
0
240
899
3.24
49.19
4.0
2.4
23.62
23.56
%
0.02
226
766
498
2856
2.58
44.26
6.1
4.6
37.07
36.46
g/l
1.75
463
2684
244
988
2.98
43.11
3.9
2.3
2.44
2.42
g/l
0.29
232
905
256
1084
2.87
41.49
3.9
2.3
14.09
14.01
umol/l
0.06
245
1001
260
1160
2.72
37.69
3.8
2.6
2.41
2.43
mmol/l
1.88
243
1018
176
639
3.16
37.20
3.4
4.5
224.87
250.74
u/l
0.89
166
605
410
2341
2.33
34.26
3.7
3.2
2.35
2.35
mmol/l
0.05
373
2099
343
1819
2.39
33.92
3.5
2.1
2.83
2.87
mg/l
0.11
298
1560
169
651
2.95
31.90
3.3
3.0
1.70
1.75
%
0.29
153
583
518
3360
2.21
30.67
7.6
6.6
1.22
1.22
mmol/l
0.17
438
2879
474
3002
2.17
29.40
8.3
5.9
1.22
1.22
mmol/l
0.14
445
2751
738
5648
2.43
27.65
8.5
6.8
74.66
76.75
u/l
0.73
705
5321
539
3655
2.11
27.20
6.1
5.9
10.22
10.78
umol/l
0.36
514
3465
622
4469
2.16
26.74
9.2
8.7
4.00
3.97
e9/l
0.14
572
3930
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
67
159
4.46
26.23
5.4
4.2
0.30
0.37
u/ml
1.00
41
79
551
3815
2.07
25.70
7.1
5.8
28.75
29.13
%
0.38
528
3608
542
3773
2.03
24.39
6.9
5.6
56.91
56.56
%
0.30
520
3561
562
4080
1.94
21.07
6.0
4.6
6.35
6.52
mmol/l
0.93
537
3744
57
145
4.12
20.37
1.3
1.2
4.03
5.34
u/ml
0.29
29
61
56
145
4.04
19.54
1.3
1.2
2.68
3.18
u/ml
0.11
19
50
54
137
4.12
19.37
1.1
1.1
—
—
—
0
0
537
3919
1.86
18.95
4.4
2.8
91.31
90.69
ug/l
0.03
507
3682
706
5636
2.01
18.88
5.0
3.9
9.82
10.47
mm/h
0.69
674
5266
42
95
4.58
17.44
2.5
2.2
—
—
—
0
0
33
62
5.48
16.93
1.3
1.5
12.94
10.73
umol/l
1.01
33
57
366
2464
1.79
16.00
3.6
3.0
—
—
—
0
0
321
2078
1.83
15.98
3.3
3.0
27.07
84.34
e6/l
1.03
259
1548
237
1402
1.92
15.60
2.6
2.5
6.09
6.84
e6/l
0.30
213
1240
296
1888
1.83
15.35
3.2
2.8
0.29
0.37
e6/l
0.54
241
1383
484
3584
1.72
14.77
3.3
2.5
—
—
—
0
0
14
0
+∞
14.62
2.5
0.0
—
—
—
0
0
868
7784
2.50
13.17
18.9
12.5
3.91
3.93
mmol/l
2.35
857
7570
866
7759
2.48
13.15
19.1
12.5
139.57
139.63
mmol/l
0.41
857
7565
875
7886
2.58
12.94
17.7
11.6
18.99
20.78
mg/l
0.89
742
6065
12
0
+∞
12.52
1.4
0.0
—
—
—
0
0
265
1755
1.71
11.52
3.0
2.1
—
—
—
0
0
360
2587
1.63
11.41
3.5
3.2
26.80
29.63
u/l
1.88
343
2469
796
7047
1.85
10.37
21.6
14.0
14.52
14.45
%
0.16
790
6940
103
522
2.09
10.26
5.8
3.3
1.22
1.23
mmol/l
0.39
95
444
230
1515
1.69
10.02
2.8
3.1
1241.11
1025.75
ng/l
0.36
182
1249
333
2417
1.58
9.77
3.2
3.2
20.26
49.49
ng/l
0.99
180
1387
419
3213
1.55
9.61
2.9
2.3
74.78
75.20
nmol/l
0.11
397
2944
309
2211
1.59
9.60
2.4
2.4
53.87
58.45
u/l
1.03
291
2056
211
1382
1.68
9.31
1.3
1.3
32.66
13.43
u/ml
0.46
82
578
186
1181
1.72
9.20
3.7
3.3
392.85
336.81
ng/l
0.11
123
770
217
1443
1.66
9.01
1.3
1.3
27.85
28.59
iu/ml
0.03
65
488
801
7200
1.76
8.65
15.6
10.1
89.23
87.96
ml/min/173m2
0.90
714
5850
108
594
1.92
8.55
2.7
2.8
9.41
10.32
g/l
1.94
101
547
60
263
2.37
8.51
1.6
1.9
—
—
—
0
0
267
1918
1.55
7.89
1.7
1.7
1.47
1.36
mmol/l
1.10
233
1661
352
2690
1.49
7.74
2.0
1.8
100.75
96.86
pmol/l
0.71
200
1427
159
1018
1.68
7.54
2.1
1.8
—
—
—
0
0
886
8298
2.18
7.40
13.0
9.2
25.20
25.44
u/l
0.18
872
8065
124
748
1.76
7.28
2.4
2.0
357.68
371.44
nmol/l
0.41
116
691
137
851
1.71
7.25
8.7
6.1
1.07
1.07
mmol/l
0.03
131
789
12
10
12.14
7.09
1.2
1.1
15.19
18.75
umol/l
—
12
10
115
688
1.77
6.95
2.0
1.7
—
—
—
0
0
21
57
3.75
6.94
1.2
1.1
—
—
—
0
0
466
3819
1.44
6.88
4.1
3.3
0.00
0.00
estimate
0.50
131
777
113
679
1.75
6.72
1.9
1.7
—
—
—
0
0
15
21
7.24
6.72
2.6
2.0
51.17
76.56
ug/l
0.53
15
21
239
1730
1.51
6.66
3.2
2.5
1724.18
5550.88
umol/l
1.52
212
1542
56
268
2.16
6.50
1.6
1.6
0.22
0.24
g/l
1.04
56
252
108
647
1.76
6.49
3.4
3.0
—
—
—
0
0
271
2022
1.48
6.49
4.7
3.6
0.00
0.01
estimate
1.28
126
734
100
587
1.79
6.44
1.4
1.2
73.43
201.29
u/ml
2.25
91
539
712
6354
1.50
6.43
5.2
4.1
14.52
14.48
pmol/l
0.18
672
5922
260
1938
1.47
6.22
2.4
2.1
173.70
245.40
u/l
0.53
252
1830
57
281
2.09
6.15
1.6
1.5
1.12
1.19
g/l
0.97
57
263
584
5042
1.42
6.13
5.2
4.0
158.50
1317.41
e6/l
—
10
63
164
1119
1.56
5.94
2.1
2.5
87.19
102.34
ug/g
0.45
124
888
36
149
2.47
5.85
3.6
3.8
57.83
56.58
%
0.22
36
149
158
1073
1.57
5.83
2.8
2.6
2.86
3.27
e6/l
0.28
90
565
128
829
1.63
5.76
4.0
3.0
8.81
7.53
umol/l
0.16
107
718
165
1137
1.55
5.71
2.8
2.4
0.62
0.99
e6/l
2.36
97
624
463
3871
1.39
5.69
4.2
3.3
0.00
0.01
estimate
0.80
124
721
35
145
2.47
5.68
3.1
3.5
4.14
4.15
e9/l
0.01
35
145
457
3828
1.38
5.48
5.4
4.5
0.00
0.00
estimate
0.50
127
741
101
625
1.69
5.41
10.9
9.1
0.88
1.19
mmol/l
0.32
81
498
48
240
2.05
5.03
1.3
1.2
45.02
14.82
u/ml
—
5
14
60
325
1.90
5.02
1.7
1.6
—
—
—
0
0
45
220
2.10
5.00
1.3
1.2
3.93
2.94
u/ml
—
7
24
93
578
1.68
4.91
3.3
3.4
4.51
4.57
pmol/l
0.22
83
506
28
112
2.55
4.91
3.8
2.5
17.33
16.26
%
0.54
13
61
235
1788
1.42
4.89
1.8
1.5
2.16
2.17
g/l
0.06
155
1105
45
224
2.06
4.78
1.3
1.2
2.72
13.63
u/ml
—
10
41
265
2074
1.39
4.65
1.4
1.3
0.62
1.75
u/ml
3.00
86
553
77
466
1.71
4.50
2.7
2.9
66.73
67.20
g/l
0.25
71
427
89
561
1.65
4.47
2.2
2.2
2887.22
4037.17
u/l
0.26
32
236
75
453
1.71
4.42
1.7
1.6
—
—
—
0
0
70
417
1.73
4.33
2.9
3.0
182.91
146.24
ng/l
0.32
64
382
792
7384
1.46
4.30
6.0
4.8
1.80
1.97
mu/l
0.51
746
6935
359
2979
1.33
4.25
4.4
3.4
—
—
—
0
0
100
663
1.57
4.10
2.4
2.4
229.51
106.20
u/l
0.25
90
555
39
196
2.03
4.08
1.3
1.2
52.07
27.04
u/ml
—
7
18
19
69
2.79
4.04
1.8
1.7
33.47
32.12
pg
0.87
19
69
258
2052
1.35
4.02
3.4
3.2
7.61
7.78
mmol/l
0.24
225
1787
915
8872
2.18
3.78
27.7
17.2
257.80
260.05
e9/l
0.44
909
8683
914
8864
2.13
3.68
27.9
17.2
40.21
40.14
%
0.18
885
8426
670
6130
1.32
3.67
3.7
3.5
—
—
—
0
0
915
8880
2.14
3.63
27.7
17.2
4.50
4.50
e12/l
0.19
909
8678
44
241
1.87
3.62
1.5
2.1
1.38
1.46
g/l
0.24
38
209
8
13
6.20
3.50
3.3
3.0
—
—
—
0
0
13
36
3.65
3.50
1.1
1.1
1852.08
1589.39
miu/ml
0.36
13
36
35
180
1.98
3.47
1.8
1.5
—
—
—
0
0
21
88
2.42
3.41
1.1
1.1
—
—
—
0
0
31
154
2.05
3.38
1.2
1.2
—
—
—
0
0
15
53
2.86
3.37
2.4
2.6
—
—
—
0
0
39
211
1.89
3.35
2.2
1.9
1.99
2.57
ug/l
0.13
34
193
33
173
1.94
3.13
1.5
1.6
—
—
—
0
0
80
539
1.53
3.09
3.9
4.1
87.78
74.19
ng/l
0.51
72
487
43
247
1.78
3.08
1.9
2.0
2.58
5.16
iu/l
2.87
17
94
32
167
1.95
3.07
1.5
1.6
—
—
—
0
0
594
5413
1.26
2.99
3.6
3.0
44.01
40.03
u/l
0.63
556
5167
61
390
1.60
2.96
1.6
1.4
—
—
—
0
0
193
1535
1.32
2.93
1.7
1.5
21.69
21.11
nmol/l
0.20
169
1339
144
1097
1.37
2.91
1.7
1.7
1132.30
1184.57
nmol/l
0.27
110
842
20
90
2.25
2.81
1.5
1.5
—
—
—
0
0
796
7553
1.35
2.81
4.6
3.9
4.69
4.76
mmol/l
1.07
750
7146
25
124
2.04
2.78
1.5
1.5
—
—
—
0
0
23
112
2.08
2.69
1.3
1.6
—
—
—
0
0
33
184
1.82
2.64
1.5
1.2
—
—
—
0
0
62
410
1.55
2.64
1.8
1.7
—
—
—
0
0
38
222
1.74
2.61
2.7
1.9
—
—
—
0
0
241
2003
1.27
2.61
1.8
1.6
—
—
—
0
0
5
7
7.17
2.55
1.6
1.9
—
—
—
0
0
16
69
2.34
2.49
1.6
1.6
—
—
—
0
0
9
26
3.48
2.48
2.4
2.3
—
—
—
0
0
27
144
1.90
2.48
1.4
1.7
—
—
—
0
0
29
159
1.85
2.46
1.7
2.0
0.00
0.00
g/l
-0.00
29
148
31
174
1.81
2.44
1.5
1.3
231.35
242.00
u/ml
0.09
20
104
25
131
1.93
2.42
1.6
1.5
—
—
—
0
0
25
131
1.93
2.42
1.6
1.5
—
—
—
0
0
18
83
2.19
2.42
1.1
1.1
—
—
—
0
0
19
90
2.13
2.40
1.7
1.5
—
—
—
0
0
19
90
2.13
2.40
1.7
1.5
—
—
—
0
0
18
84
2.17
2.36
1.1
1.1
—
—
—
0
0
18
84
2.17
2.36
1.1
1.1
—
—
—
0
0
18
84
2.17
2.36
1.1
1.1
—
—
—
0
0
8
23
3.50
2.27
1.0
1.0
88.62
96.57
%
—
8
23
9
29
3.12
2.23
1.0
1.4
—
—
—
0
0
760
7226
1.27
2.20
4.1
3.5
1.35
1.24
mmol/l
1.98
718
6788
17
80
2.15
2.19
1.6
1.6
—
—
—
0
0
787
7517
1.29
2.18
4.5
3.8
1.44
1.50
mmol/l
4.24
742
7085
34
204
1.69
2.17
13.9
4.3
1.13
1.31
mmol/l
0.98
34
199
6
14
4.31
2.15
1.0
1.0
—
—
—
0
0
63
440
1.46
2.12
2.2
2.4
6.75
6.93
ug/l
0.03
55
394
15
68
2.23
2.11
17.3
9.0
7.09
6.41
mmol/l
0.36
15
54
218
1834
1.25
2.10
4.2
3.9
11.13
9.68
mg/mmol
0.20
145
1175
18
89
2.04
2.07
1.2
1.1
1.33
1.42
g/l
0.37
18
81
798
7650
1.29
2.04
4.9
4.2
2.81
2.84
mmol/l
0.47
751
7196
26
147
1.79
2.04
1.2
1.1
—
—
—
0
0
61
427
1.46
2.03
6.5
4.2
1.63
1.66
mmol/l
0.02
43
309
17
83
2.07
2.02
1.1
1.1
—
—
—
0
0
27
155
1.76
2.02
1.8
1.5
102.50
108.31
u/ml
—
8
28
18
91
2.00
1.96
1.6
1.5
—
—
—
0
0
79
587
1.38
1.91
5.6
4.5
2.20
1.80
mmol/l
0.56
71
474
27
158
1.73
1.90
2.4
2.8
—
—
—
0
0
196
1649
1.24
1.88
4.6
3.5
1.02
1.02
kg/l
0.21
29
214
19
100
1.92
1.86
1.4
1.3
—
—
—
0
0
11
46
2.41
1.85
1.0
1.2
—
—
—
0
0
32
198
1.64
1.85
9.7
4.3
8.11
8.75
kpa
1.20
32
193
5
12
4.18
1.82
2.6
1.8
—
—
—
0
0
206
1750
1.23
1.81
3.3
3.3
412.12
315.67
mg/l
0.11
139
1133
24
138
1.76
1.80
2.3
2.0
5.28
4.94
mmol/24h
0.20
19
120
24
139
1.75
1.77
1.2
1.1
—
—
—
0
0
33
209
1.60
1.76
1.6
1.4
341.17
309.47
ug/g
0.34
20
116
23
132
1.76
1.75
1.3
1.3
—
—
—
0
0
23
132
1.76
1.75
1.3
1.3
—
—
—
0
0
8
30
2.68
1.72
1.0
1.3
—
—
—
0
0
5
13
3.86
1.71
1.8
1.7
—
—
—
0
0
10
40
2.52
1.67
2.8
2.4
31.50
27.88
umol/l
—
10
40
8
31
2.59
1.66
1.0
1.3
—
—
—
0
0
8
31
2.59
1.66
1.0
1.3
—
—
—
0
0
39
261
1.52
1.66
1.5
1.3
—
—
—
0
0
7
25
2.81
1.65
1.1
1.2
—
—
—
0
0
14
69
2.04
1.65
1.7
1.3
—
—
—
0
0
11
49
2.26
1.64
1.8
1.4
13.86
23.46
ug/l
1.25
11
49
128
1043
1.26
1.64
1.6
1.7
1.48
1.39
%
0.42
108
949
17
91
1.88
1.61
1.1
1.4
—
—
—
0
0
7
26
2.70
1.58
1.0
1.4
—
—
—
0
0
17
92
1.86
1.56
1.1
1.4
—
—
—
0
0
14
71
1.99
1.54
1.2
1.5
—
—
—
0
0
42
291
1.46
1.53
11.3
9.6
23.97
24.35
mmol/l
0.49
42
282
9
37
2.45
1.48
1.7
2.9
560.78
610.59
u/ml
—
9
37
14
73
1.93
1.44
1.3
1.2
0.29
2.67
u/ml
—
8
37
5
16
3.14
1.44
1.0
1.2
—
—
—
0
0
43
305
1.43
1.41
2.0
1.8
—
—
—
0
0
75
584
1.31
1.39
2.7
4.2
2.93
38.67
ug/l
1.51
51
472
11
53
2.09
1.39
1.2
1.4
—
—
—
0
0
13
67
1.95
1.38
1.0
1.1
—
—
—
0
0
25
158
1.60
1.38
1.3
1.3
—
—
—
0
0
19
112
1.71
1.36
1.6
1.3
—
—
—
0
0
42
300
1.42
1.33
1.6
1.5
13.15
9.45
u/l
0.53
32
242
16
91
1.77
1.29
1.1
1.4
—
—
—
0
0
91
736
1.26
1.27
1.2
1.2
167.10
153.65
iu/ml
0.11
36
302
705
6770
1.17
1.25
5.6
4.8
38.61
38.69
mmol/mol
0.07
647
6397
177
1537
1.19
1.24
2.3
2.2
—
—
—
0
0
36
254
1.43
1.23
1.4
1.1
—
—
—
0
0
15
85
1.78
1.23
1.0
1.2
—
—
—
0
0
38
271
1.42
1.23
1.2
1.3
—
—
—
0
0
12
63
1.92
1.23
3.6
1.6
—
—
—
0
0
12
63
1.92
1.23
1.3
1.3
—
—
—
0
0
5
19
2.64
1.21
3.4
5.2
—
—
—
0
0
16
93
1.73
1.21
1.1
1.4
—
—
—
0
0
18
109
1.66
1.19
1.4
1.5
—
—
—
0
0
6
26
2.32
1.19
1.0
1.1
90.17
101.94
nmol/l
—
6
20
6
26
2.32
1.19
1.5
1.5
10.46
8.20
ug/l
—
6
26
12
64
1.89
1.18
1.3
1.3
—
—
—
0
0
16
94
1.71
1.18
1.1
1.4
—
—
—
0
0
16
94
1.71
1.18
1.1
1.4
—
—
—
0
0
10
50
2.01
1.16
1.2
2.7
—
—
—
0
0
32
226
1.43
1.11
8.7
6.5
1.63
1.34
mg/l
0.63
27
211
18
112
1.62
1.09
1.1
1.1
—
—
—
0
0
7
32
2.20
1.08
1.0
1.2
—
—
—
0
0
754
7304
1.16
1.08
4.4
3.9
5.80
5.75
mmol/l
0.36
691
6788
5
22
2.28
1.03
1.2
1.0
—
—
—
0
0
11
61
1.81
0.98
1.3
1.4
—
—
—
0
0
15
92
1.64
0.97
1.2
1.1
—
—
—
0
0
65
525
1.26
0.96
1.3
1.4
—
—
—
0
0
34
252
1.36
0.93
1.2
1.2
—
—
—
0
0
76
628
1.23
0.93
1.5
1.5
19.70
24.96
iu/l
1.03
64
525
10
55
1.83
0.92
1.1
1.1
—
61.88
—
0
8
15
94
1.61
0.91
1.2
1.1
—
—
—
0
0
24
168
1.44
0.90
1.1
1.4
—
—
—
0
0
37
280
1.33
0.89
2.5
1.8
—
—
—
0
0
156
1381
1.16
0.89
2.3
2.0
—
—
—
0
0
6
30
2.01
0.87
1.0
1.3
—
—
—
0
0
11
64
1.73
0.86
1.2
1.3
—
—
—
0
0
11
64
1.73
0.86
1.1
1.0
—
—
—
0
0
6
31
1.94
0.84
1.2
1.5
—
—
—
0
0
8
45
1.78
0.84
1.1
1.6
—
—
—
0
0
33
251
1.33
0.79
1.2
1.2
—
—
—
0
0
6
33
1.82
0.79
1.5
1.8
—
—
—
0
0
6
33
1.82
0.79
1.5
1.8
—
—
—
0
0
11
66
1.67
0.79
1.5
1.5
—
—
—
0
0
11
66
1.67
0.79
1.5
1.5
—
—
—
0
0
11
66
1.67
0.79
1.5
1.5
—
—
—
0
0
23
165
1.40
0.78
1.1
1.4
—
—
—
0
0
13
198
0.65
0.77
1.2
1.1
0.42
2.09
u/ml
—
5
110
15
100
1.51
0.73
3.3
5.0
60.73
64.09
%
0.21
15
100
90
777
1.18
0.73
6.7
5.9
—
—
—
0
0
13
84
1.56
0.72
1.2
1.1
—
—
—
0
0
5
26
1.93
0.70
1.6
1.3
—
—
—
0
0
9
58
1.56
0.70
1.2
1.3
74.78
72.79
umol/l
—
9
58
31
241
1.30
0.66
1.3
1.4
124.74
112.40
pmol/l
0.07
31
235
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
7
44
1.60
0.65
2.7
2.9
35344.57
37852.39
ug/l
—
7
44
25
189
1.33
0.65
1.8
1.5
0.30
0.37
nmol/l
0.46
20
157
156
1415
1.12
0.64
1.9
1.7
478.02
33008563.38
pmol/l
1.82
127
1230
47
390
1.22
0.60
1.2
1.3
216.31
230.30
miu/ml
0.10
23
198
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
51
1.57
0.60
1.1
1.1
—
—
—
0
0
32
254
1.27
0.60
2.5
1.7
—
—
—
0
0
6
35
1.72
0.57
1.0
1.0
—
—
—
0
0
11
74
1.49
0.53
1.1
1.8
49.50
56.35
%
—
6
49
34
277
1.24
0.53
2.8
3.7
1.42
1.22
%
0.46
34
277
33
268
1.24
0.53
2.8
3.7
0.67
0.65
%
0.11
33
268
9
63
1.43
0.52
1.3
1.2
—
—
—
0
0
21
161
1.31
0.52
1.8
1.8
—
—
—
0
0
6
41
1.47
0.50
1.2
1.6
—
—
—
0
0
6
41
1.47
0.50
1.2
1.6
—
—
—
0
0
15
110
1.37
0.49
1.2
1.3
—
—
—
0
0
77
865
0.88
0.48
1.5
1.6
—
—
—
0
0
7
47
1.49
0.47
1.1
1.1
—
—
—
0
0
7
48
1.46
0.47
1.0
1.0
—
—
—
0
0
34
285
1.20
0.43
5.5
3.8
25.92
25.12
mmol/l
0.74
34
278
82
739
1.12
0.41
2.1
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
7.58
—
0
11
8
59
1.36
0.41
2.0
1.6
0.87
0.98
g/l
—
8
59
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
45
391
1.16
0.39
1.7
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
3.4
—
1.23
—
0
19
22
178
1.24
0.39
3.0
2.6
6.08
6.76
umol/l
0.14
17
130
5
36
1.39
0.38
1.0
1.1
165.20
171.90
iu/ml
—
5
36
103
946
1.10
0.38
2.2
1.8
—
—
—
0
0
12
89
1.35
0.38
1.6
1.5
—
—
—
0
0
88
802
1.11
0.38
4.2
3.9
30.43
31.93
%
0.62
65
585
15
116
1.30
0.37
1.4
1.5
—
—
—
0
0
10
72
1.39
0.37
1.5
1.3
—
—
—
0
0
19
153
1.25
0.35
1.3
1.7
2432.38
17253.19
e6/l
—
8
113
6
42
1.43
0.35
2.7
1.7
—
77.80
%
—
0
5
6
42
1.43
0.35
1.0
1.1
—
—
—
0
0
31
360
0.86
0.33
1.8
1.9
—
—
—
0
0
7
54
1.30
0.30
1.0
1.2
—
—
—
0
0
7
55
1.27
0.30
1.4
1.0
—
—
—
0
0
8
62
1.29
0.28
1.3
1.4
—
—
—
0
0
40
356
1.13
0.27
1.7
1.6
—
—
—
0
0
19
226
0.84
0.27
1.2
1.1
1.76
3.14
u/ml
—
10
127
5
71
0.70
0.26
1.2
2.6
105.20
106.00
mmol/l
—
5
71
10
77
1.30
0.26
1.1
1.2
—
—
—
0
0
19
161
1.18
0.24
1.2
1.0
0.76
2.43
u/ml
—
8
81
35
390
0.89
0.23
1.5
1.7
4.88
4.82
mg/l
0.01
24
284
71
661
1.08
0.22
2.9
2.7
0.67
0.76
ug/l
0.38
47
405
5
42
1.19
0.21
2.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
29.03
—
0
9
15
176
0.85
0.20
1.3
1.1
—
—
—
0
0
6
50
1.20
0.19
1.2
1.5
1.47
1.60
g/l
—
6
50
24
212
1.14
0.19
2.9
3.1
2213.21
1676.93
u/ml
0.08
19
187
57
533
1.07
0.17
1.1
1.0
—
—
—
0
0
6
76
0.79
0.15
2.3
1.9
—
—
—
0
0
16
140
1.15
0.15
3.6
3.8
40.90
27.72
mg/l
—
10
91
7
87
0.80
0.14
1.1
1.4
—
—
—
0
0
38
408
0.93
0.14
1.5
1.4
—
—
—
0
0
13
146
0.89
0.10
1.2
1.1
166.29
3200.67
iu/ml
—
7
40
77
744
1.04
0.09
1.6
1.5
—
—
—
0
0
6
57
1.05
0.08
2.2
2.2
—
—
—
0
0
30
318
0.94
0.08
1.8
1.7
—
—
—
0
0
89
912
0.97
0.06
3.7
3.9
24.94
21.65
%
0.91
41
385
47
487
0.96
0.06
1.6
1.4
—
—
—
0
0
117
1148
1.02
0.06
4.3
4.4
1.94
2.23
ug/l
0.28
103
1038
16
172
0.93
0.06
2.8
1.5
39.69
40.70
nmol/l
0.07
16
166
20
211
0.95
0.04
1.8
1.6
—
—
—
0
0
39
401
0.97
0.03
1.6
1.4
—
—
—
0
0
39
400
0.97
0.02
1.6
1.4
—
—
—
0
0
28
273
1.03
0.01
1.6
1.5
—
—
—
0
0
183
1838
0.99
0.01
1.6
1.5
—
—
—
0
0
40
402
0.99
0.00
1.6
1.4
—
—
—
0
0
44
438
1.00
0.00
1.5
1.5
—
—
—
0
0
40
401
1.00
0.00
1.6
1.4
—
—
—
0
0
18
185
0.97
0.00
1.2
1.3
—
—
—
0
0
11
115
0.96
0.00
3.1
1.6
133.18
205.54
pmol/l
1.21
11
109
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
4.64
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
8.37
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
50
1.00
-0.00
1.6
1.5
—
—
—
0
0
5
49
1.02
-0.00
1.8
1.5
0.60
5.03
u/field
—
5
40
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_COAGDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF | 1.541 [1.28, 1.85] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 3408 females with D3_COAGDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF | 1.698 [1.39, 2.07] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1530 males with D3_COAGDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_COAGDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.349% |
| 5 | 0.891% | 1.949% |
| 10 | 2.227% | 4.778% |
| 15 | 4.197% | 8.71% |
| 20 | 7.44% | 14.826% |
Relationships between endpoints
↥Index endpoint: D3_COAGDEF – Chronic Coagulation defects
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data