primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
722 |
4. Check minimum number of eventsNone |
722 |
5. Include endpointsNone |
722 |
6. Filter based on genotype QC (FinnGen only) |
722 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E28
- Name in latin
- Insufficientia ovariorum primaria
Similar endpoints
↥List of similar endpoints to
Primary ovarian failure
based on the number of shared cases.
Similar with more cases:
- Ovarian dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2798 | 2798 | - |
| Only index persons | 2690 | 2690 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.10 | 0.10 | - |
| Median age at first event (years) | |||
| Whole population | - | 36.22 | - |
| Only index persons | - | 36.17 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 722 | 722 | - |
| Unadjusted period prevalence (%) | 0.25 | 0.25 | - |
| Median age at first event (years) | 37.87 | 37.87 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 644
- Matched controls
- 6440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E28.3
ICD-10 Finland
Primary ovarian failure
2317.7
323.0
336
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
264.2
323.0
419
45
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
6.2
97.0
483
2089
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
10.1
91.8
201
276
N91.1
ICD-10 Finland
Secondary amenorrhoea
18.1
61.7
98
63
25610
ICD-8 Finland
Ovarian dysfunction, Hypofunction
+∞
60.4
57
*
G03FB06
ATC
medroxyprogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
8.7
55.7
128
178
G03FB05
ATC
norethisterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
5.8
51.6
165
363
G03DB01
ATC
dydrogesterone; oral
3.6
40.9
229
848
G03FA01
ATC
norethisterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
4.0
32.3
145
434
E28.8
ICD-10 Finland
Other ovarian dysfunction
293.6
28.0
28
*
E28.9
ICD-10 Finland
Ovarian dysfunction, unspecified
+∞
25.2
24
*
N97.8
ICD-10 Finland
Female infertility of other origin
7.0
24.4
62
97
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.3
23.0
336
2058
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
21.9
217
1083
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
32.4
21.6
28
9
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
3.7
19.8
93
283
G03FA12
ATC
medroxyprogesterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
4.3
18.5
71
180
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.7
18.1
63
145
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
17.8
17
*
N91.0
ICD-10 Finland
Primary amenorrhoea
97.8
17.6
19
*
H02AB09
ATC
hydrocortisone; systemic
10.5
17.1
33
33
G03GA02
ATC
human menopausal gonadotrophin; parenteral
4.4
15.9
59
145
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
15.7
15
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
15.6
230
1343
L04AA01
ATC
[U] ciclosporin; systemic
11.2
14.1
26
24
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
16.2
14.0
22
14
G03FB09
ATC
levonorgestrel and estrogen; systemic (progestogens and estrogens, sequential prep.)
7.7
13.6
31
42
N80.1
ICD-10 Finland
Endometriosis of ovary
3.8
13.6
59
168
N97.0
ICD-10 Finland
Female infertility associated with anovulation
5.1
12.7
40
83
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
9.0
12.6
26
30
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
5.4
12.5
37
72
G03DA04
ATC
progesterone; systemic, rectal, vaginal
3.6
12.3
56
166
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.2
12.2
139
716
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
6.6
12.0
30
47
LCD00
NOMESCO Finland
Hysterectomy
3.5
11.7
55
167
N95.1
ICD-10 Finland
Menopausal and female climacteric states
2.3
11.6
122
603
H01AC01
ATC
somatropin; parenteral
122.1
11.5
12
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
11.4
95
418
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
11.1
170
985
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.5
10.6
138
2192
127
Kela drug reimbursment
Transplant complication
10.3
10.6
20
20
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
10.4
10
*
E
ICD-9 Finland
NA
23.8
10.3
14
6
A02BC02
ATC
pantoprazole; systemic
1.7
10.3
396
3087
H03AA01
ATC
levothyroxine sodium; systemic
1.9
10.2
181
1102
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
2.2
10.1
117
602
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
3.2
10.1
52
170
G03FA14
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
2.6
9.9
73
301
B01AB05
ATC
enoxaparin; parenteral
1.9
9.8
175
1068
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
9.6
231
1553
N02AA05
ATC
oxycodone; systemic
2.7
9.6
67
268
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
9.4
9
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
+∞
9.4
9
*
G03GA01
ATC
chorionic gonadotrophin; parenteral
2.8
9.3
61
232
H02AB06
ATC
prednisolone; systemic
1.7
9.2
289
2091
A02BC05
ATC
esomeprazole; systemic
1.7
9.1
249
1732
G02BA03
ATC
plastic IUD with progestogen
0.4
9.1
48
1030
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
15.9
9.1
14
9
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.2
9.0
27
54
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
0.4
8.9
40
909
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.4
8.7
55
1109
LAF00
NOMESCO Finland
Unilateral salpingo-oophorectomy
5.3
8.5
25
49
H02AA02
ATC
fludrocortisone; oral
20.3
8.5
12
6
L03AA02
ATC
filgrastim; parenteral
5.2
8.4
25
50
Z3226
NOMESCO Finland
Physiotherapist
2.0
8.4
112
610
102
Kela drug reimbursment
Diabetes insipidus
+∞
8.3
8
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
8.3
8
*
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
10.9
8.3
15
14
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
8.1
214
1463
Z31.5
ICD-10 Finland
Genetic counselling
2.5
8.1
61
254
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.8
8.0
51
194
C03CA01
ATC
furosemide; systemic
2.2
7.9
87
436
W12
ICPC
Contraception intrauterine
0.4
7.9
27
686
G03FB01
ATC
norgestrel and estrogen; systemic (progestogens and estrogens, sequential prep.)
9.6
7.8
15
16
N80.9
ICD-10 Finland
Endometriosis, unspecified
3.7
7.8
32
89
1413
FHL
Laparoscopy and other therapeutic procedure
4.1
7.8
29
74
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.3
7.6
22
43
N80.5
ICD-10 Finland
Endometriosis of intestine
10.2
7.6
14
14
G03DC02
ATC
norethisterone; oral
2.1
7.5
91
478
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
7.4
68
313
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.8
7.4
129
770
A12AA04
ATC
calcium carbonate; oral
13.6
7.4
12
9
N80.81
ICD-10 Finland
Endometriosis in sacrouteral ligament
11.0
7.3
13
12
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
7.3
7
*
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
5.3
7.3
21
41
E89.4
ICD-10 Finland
Postprocedural ovarian failure
30.4
7.2
9
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
7.1
84
436
JAH01
NOMESCO Finland
Laparoscopy
2.6
7.1
50
203
UKC02
NOMESCO Finland
Cystoscopy
2.4
7.0
58
256
H01CA02
ATC
nafarelin; nasal
2.8
7.0
44
164
8113
FHL
Fractional scraping
3.1
7.0
36
120
Z31.2
ICD-10 Finland
In vitrofertilization
6.4
7.0
17
27
R4110
NOMESCO Finland
Physiotherapy
1.7
6.9
149
953
L04AD01
ATC
ciclosporin; systemic
5.1
6.8
20
40
JAL96
NOMESCO Finland
Other excision of lesion of peritoneum
22.8
6.7
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.7
163
1080
P01BA02
ATC
hydroxychloroquine; oral
2.3
6.6
63
296
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.9
6.6
39
142
130
Kela drug reimbursment
Malignant tumour
3.3
6.6
31
97
KBV10
NOMESCO Finland
Removal of stent from ureter
8.8
6.6
13
15
G03DC05
ATC
[U] tibolone; oral
3.8
6.5
26
71
Z31.6
ICD-10 Finland
General counselling and advice on procreation
7.0
6.5
15
22
A02BC01
ATC
omeprazole; systemic
1.7
6.5
146
942
N97.9
ICD-10 Finland
Female infertility, unspecified
2.1
6.5
69
341
JN4BD
NOMESCO Finland
Extensive body CT
2.5
6.5
49
206
G03GA06
ATC
follitropin beta; parenteral
2.9
6.5
38
138
UJF32
NOMESCO Finland
Coloscopy
1.8
6.5
126
782
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
6.5
116
698
M01AH02
ATC
rofecoxib; oral
2.2
6.4
66
322
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
6.4
59
274
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
6.4
41
157
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.7
6.3
164
1101
G03DC03
ATC
lynestrenol; oral
3.3
6.3
29
90
106
Kela drug reimbursment
Hypoparathyroidism
+∞
6.3
6
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
6.3
6
*
A11CC02
ATC
dihydrotachysterol; oral
26.9
6.2
8
*
R50.9
ICD-10 Finland
Fever, unspecified
2.0
6.2
83
449
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.1
6.2
69
348
UJG02
NOMESCO Finland
Proctoscopy
5.8
6.2
16
28
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
6.2
71
364
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
4.3
6.2
21
50
L02AE02
ATC
leuprorelin; implant, parenteral
3.8
6.1
24
65
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.8
6.1
14
21
6202X
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Other and unspecified ovarian cyst
5.3
6.0
17
33
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.6
6.0
40
158
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.0
101
596
Mortality – FinRegistry
↥Association
Association between endpoint E4_OVARFAIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OVARFAIL | 2.676 [2.14, 3.35] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.077 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 2006 females with E4_OVARFAIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_OVARFAIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | No data |
| 5 | 1.402% | No data |
| 10 | 3.668% | No data |
| 15 | 7.081% | No data |
| 20 | 11.799% | No data |
Relationships between endpoints
↥Index endpoint: E4_OVARFAIL – Primary ovarian failure
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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