primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly females |
293218 |
2. Check conditionsNone |
293218 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
755 |
4. Check minimum number of eventsNone |
755 |
5. Include endpointsNone |
755 |
6. Filter based on genotype QC (FinnGen only) |
686 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E28
- Name in latin
- Insufficientia ovariorum primaria
Similar endpoints
↥List of similar endpoints to
Primary ovarian failure
based on the number of shared cases.
Similar with more cases:
- Ovarian dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2798 | 2798 | - |
| Only index persons | 2690 | 2690 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.10 | 0.10 | - |
| Median age at first event (years) | |||
| Whole population | - | 36.22 | - |
| Only index persons | - | 36.17 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 686 | 686 | - |
| Unadjusted period prevalence (%) | 0.24 | 0.24 | - |
| Median age at first event (years) | 37.94 | 37.94 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 755
- Matched controls
- 7550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E28.3
ICD-10 Finland
Primary ovarian failure
1765.2
307.7
410
5
121
Kela drug reimbursment
Severe hypofunction of sexual glands
314.2
307.7
497
46
G03FB08
ATC
dydrogesterone and estrogen; systemic
10.4
179.7
243
331
N91.1
ICD-10 Finland
Secondary amenorrhoea
16.2
132.5
119
86
G03FB06
ATC
medroxyprogesterone and estrogen; systemic
9.9
119.6
153
189
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
6.8
113.4
607
2840
G03FB05
ATC
norethisterone and estrogen; systemic
5.5
82.8
196
455
25610
ICD-8 Finland
Ovarian dysfunction, Hypofunction
+∞
66.7
63
*
G03DB01
ATC
dydrogesterone; oral
3.7
59.2
268
988
N97.8
ICD-10 Finland
Female infertility of other origin
7.7
56.6
84
121
G03FA01
ATC
norethisterone and estrogen; systemic
3.7
46.7
186
620
E28.8
ICD-10 Finland
Other ovarian dysfunction
441.3
42.6
42
*
H02AB09
ATC
hydrocortisone; systemic
11.1
39.6
43
41
G03FA12
ATC
medroxyprogesterone and estrogen; systemic
4.5
31.1
82
201
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
30.9
268
1342
G03DA02
ATC
medroxyprogesterone; systemic
3.6
30.6
111
342
N97.0
ICD-10 Finland
Female infertility associated with anovulation
5.9
27.4
51
92
G03GA02
ATC
human menopausal gonadotrophin; parenteral
4.3
27.4
75
189
H01AC01
ATC
somatropin; parenteral
+∞
27.2
26
*
E28.9
ICD-10 Finland
Ovarian dysfunction, unspecified
+∞
27.2
26
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
26.2
25
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.1
25.7
75
198
G03FB09
ATC
levonorgestrel and estrogen; systemic
7.8
24.8
35
47
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.2
24.3
403
2594
L04AA01
ATC
[U] ciclosporin
9.3
22.2
27
30
N91.0
ICD-10 Finland
Primary amenorrhoea
51.6
21.2
25
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
20.6
116
460
N80.1
ICD-10 Finland
Endometriosis of ovary
3.6
19.8
68
201
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
18.3
19.7
30
17
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
7.1
19.6
30
44
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
18.8
18
*
G03FA14
ATC
dydrogesterone and estrogen; systemic
3.0
18.8
91
332
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.3
17.9
173
879
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
5.0
17.7
39
82
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
15.5
16.8
27
18
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
16.7
280
1744
H03AA01
ATC
levothyroxine sodium; systemic
2.0
16.1
231
1359
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
3.3
16.1
62
197
H02AA02
ATC
fludrocortisone; oral
46.0
15.1
18
*
LCD00
NOMESCO Finland
Hysterectomy
3.3
15.1
58
184
Z31.6
ICD-10 Finland
General counselling and advice on procreation
6.9
14.9
23
34
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
14.6
14
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
14.6
14
*
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
4.2
13.6
36
88
N95.1
ICD-10 Finland
Menopausal and female climacteric states
2.0
13.4
169
942
G03GA01
ATC
chorionic gonadotrophin; parenteral
2.7
13.1
75
298
G03DA04
ATC
progesterone; systemic, rectal, vaginal
2.9
13.1
62
223
LAF00
NOMESCO Finland
Unilateral salpingo-oophorectomy
5.5
12.8
25
47
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.7
12.7
29
63
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
12.6
198
1188
Q96.0
ICD-10 Finland
Karyotype 45,X
132.1
12.5
13
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
12.2
91
410
Z31.5
ICD-10 Finland
Genetic counselling
2.5
11.9
79
338
G03DC05
ATC
[U] tibolone
4.6
11.7
28
63
B01AB05
ATC
enoxaparin; parenteral
1.8
11.7
214
1343
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.5
11.7
162
2577
JAH01
NOMESCO Finland
Laparoscopy
2.8
11.5
61
233
E, ,
ICD-9 Finland
25.5
11.2
15
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
11.1
71
298
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
8.7
11.1
23
27
E22.1
ICD-10 Finland
Hyperprolactinaemia
60.9
10.6
12
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.9
10.6
155
903
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
10.5
88
417
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.3
10.5
84
391
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
+∞
10.4
10
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
33.0
10.4
13
*
E89.4
ICD-10 Finland
Postprocedural ovarian failure
33.0
10.4
13
*
UJF32
NOMESCO Finland
Coloscopy
1.9
10.2
158
936
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.8
10.2
52
195
C03CA01
ATC
furosemide; systemic
2.1
10.2
106
548
L03AA02
ATC
filgrastim; parenteral
4.1
10.0
27
67
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
10.0
76
346
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.9
280
1970
127
Kela drug reimbursment
Transplant complication
8.3
9.9
21
26
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
4.6
9.8
23
51
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
9.6
287
2046
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
9.5
69
307
H02AB06
ATC
prednisolone; systemic
1.6
9.5
341
2543
Q96.9
ICD-10 Finland
Turner syndrome, unspecified
101.3
9.4
10
*
8113
FHL
Fractional scraping
3.1
9.4
39
130
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
9.3
146
867
A02BC05
ATC
esomeprazole; systemic
1.6
9.2
298
2161
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.5
9.2
74
1430
-, ,
ICD-10 Finland
4.5
9.1
22
50
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
4.5
9.1
22
50
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
9.1
183
1170
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
0.4
9.0
60
1245
J01MA12
ATC
levofloxacin; systemic
2.0
8.9
107
582
L02AE03
ATC
goserelin; implant
5.0
8.9
19
39
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
3.9
8.8
26
69
A02BC02
ATC
pantoprazole; systemic
1.6
8.8
476
3885
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.3
8.8
20
28
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.3
8.7
22
52
N97.9
ICD-10 Finland
Female infertility, unspecified
2.1
8.6
84
424
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
10.2
8.6
16
16
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
8.5
114
643
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
8.5
46
178
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.8
8.5
128
751
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.7
8.4
46
179
G03GA06
ATC
follitropin beta; parenteral
2.7
8.4
46
179
A12AA04
ATC
calcium carbonate; oral
12.9
8.4
14
11
106
Kela drug reimbursment
Hypoparathyroidism
+∞
8.3
8
*
301
Kela drug reimbursment
Growth hormone
+∞
8.3
8
*
H01CC01
ATC
ganirelix; parenteral
2.7
8.3
46
180
A07AA02
ATC
nystatin; oral
2.7
8.3
44
169
6202X
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Other and unspecified ovarian cyst
4.6
8.2
19
42
UKC02
NOMESCO Finland
Cystoscopy
2.2
8.1
66
309
62400
ICD-8 Finland
Malposition of uterus, Retroversion and retroflexion
33.7
8.1
10
*
1413
FHL
Laparoscopy and other therapeutic procedure
3.3
8.0
30
94
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.3
8.0
29
89
N02AA05
ATC
oxycodone; systemic
2.1
8.0
82
421
G02BA03
ATC
plastic IUD with progestogen
0.5
8.0
58
1170
JAH00
NOMESCO Finland
Laparotomy
4.0
7.9
22
56
Z31.2
ICD-10 Finland
In vitrofertilization
4.7
7.9
18
39
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
7.9
82
423
XLA10, ,
NOMESCO Finland
2.3
7.8
59
268
H01CA02
ATC
nafarelin; nasal
2.5
7.8
50
211
G03DC03
ATC
lynestrenol; oral
3.0
7.7
34
118
R4110
NOMESCO Finland
Physiotherapy
1.7
7.7
184
1228
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.0
7.7
21
53
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.0
7.7
21
53
W12
ICPC
Contraception intrauterine
0.4
7.6
43
959
L02AE02
ATC
leuprorelin; implant, parenteral
3.2
7.6
29
92
G03DC02
ATC
norethisterone; oral
1.9
7.6
99
553
A11CC02
ATC
dihydrotachysterol; oral
25.3
7.6
10
*
L04AD01
ATC
ciclosporin; systemic
3.9
7.6
22
58
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
6.6
7.4
18
28
102
Kela drug reimbursment
Diabetes insipidus
80.9
7.4
8
*
6171A
ICD-9 Finland
Endometriosis of ovary
6.1
7.4
19
32
XW000
NOMESCO Finland
Bone marrow biopsy
3.7
7.3
23
64
N80.81
ICD-10 Finland
Endometriosis in sacrouteral ligament
9.5
7.3
14
15
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
7.3
7
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
7.3
7
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
7.3
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
7.2
237
1706
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
7.2
108
632
WW500
NOMESCO Finland
Blood transfusion
3.1
7.1
29
96
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.4
7.1
48
208
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.4
7.0
25
76
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.2
7.0
57
267
D39.10
ICD-10 Finland
Tumor of uncertain or unknown nature in the ovary without histology
3.1
7.0
29
97
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
6.9
29
98
Z3231
NOMESCO Finland
Registered nurse
1.6
6.8
183
1252
62650
ICD-8 Finland
Disorders of menstruation, Irregular
11.1
6.8
12
11
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
2.8
6.8
33
121
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
6.8
48
212
ZXE90
NOMESCO Finland
More than 22 hours
40.4
6.8
8
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.6
6.7
169
2390
KBV10
NOMESCO Finland
Removal of stent from ureter
7.3
6.7
15
21
G03GB02
ATC
clomifene; oral
2.8
6.7
32
116
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.3
6.7
50
226
6266A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Metrorrhagia
3.8
6.7
20
54
JN4BD
NOMESCO Finland
Extensive body CT
2.3
6.6
52
240
N80.8
ICD-10 Finland
Other endometriosis
12.4
6.6
11
9
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.9
6.6
19
50
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
6.5
31
112
N99.4
ICD-10 Finland
Postprocedural pelvic peritoneal adhesions
6.3
6.5
16
26
Z3226
NOMESCO Finland
Physiotherapist
1.7
6.5
127
801
H02AB07
ATC
prednisone; oral
1.8
6.5
92
528
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
70.4
6.4
7
*
ZXE80
NOMESCO Finland
More than 18 and less than 21 hours
70.4
6.4
7
*
E34.35
ICD-10 Finland
Abnormal growth retardation
70.4
6.4
7
*
P01BA02
ATC
hydroxychloroquine; oral
2.0
6.4
72
382
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.4
166
1125
L04AA06
ATC
mycophenolic acid; systemic
4.1
6.4
17
42
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.3
6.4
48
218
Z50.1
ICD-10 Finland
Other physical therapy
2.6
6.4
36
143
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.6
6.3
98
1565
JAL96
NOMESCO Finland
Other excision of lesion of peritoneum
18.2
6.3
9
5
Q96
ICD-10 Finland
Turner syndrome
+∞
6.3
6
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
6.3
6
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
6.3
6
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
+∞
6.3
6
*
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.5
6.2
208
1493
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
6.2
54
260
130
Kela drug reimbursment
Malignant tumour
2.6
6.2
34
133
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
2.4
6.2
42
182
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.6
6.2
35
139
G03FB01
ATC
norgestrel and estrogen; systemic
5.8
6.2
16
28
N95.0
ICD-10 Finland
Postmenopausal bleeding
2.0
6.1
68
359
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
0.5
6.1
54
1026
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
0.6
6.1
99
1566
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.1
92
539
N80.5
ICD-10 Finland
Endometriosis of intestine
6.8
6.1
14
21
M05BA04
ATC
alendronic acid; oral
2.6
6.0
35
141
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
137
200
8.15
92.48
1.8
1.3
0.23
0.50
nmol/l
2.55
109
166
141
222
7.58
88.87
1.6
1.2
30.06
13.22
u/l
5.31
115
175
120
206
6.74
69.09
1.5
1.4
1.12
2.99
ug/l
2.46
55
187
172
670
3.03
32.49
2.1
1.3
49.25
27.71
iu/l
6.32
144
571
36
40
9.40
29.68
1.4
1.4
—
—
—
0
0
109
423
2.84
20.16
1.5
1.3
235.83
296.92
mu/l
2.42
103
374
133
579
2.57
19.61
2.5
1.8
382.10
374.29
nmol/l
0.10
125
538
63
182
3.69
18.94
2.1
1.3
40.44
24.81
u/l
3.09
63
153
39
80
5.09
18.22
1.7
4.4
509.89
99.69
u/ml
—
8
25
150
718
2.36
17.89
1.3
1.2
132.24
150.14
iu/ml
0.16
47
300
322
2144
1.88
15.37
8.0
4.4
1.21
1.22
mmol/l
0.69
304
1970
354
2439
1.85
15.07
8.9
4.9
1.21
1.22
mmol/l
0.40
307
2081
42
109
4.02
14.67
1.1
1.1
3.00
4551.69
iu/ml
—
5
28
558
4486
1.93
13.98
8.8
6.2
74.66
73.06
u/l
0.50
528
4225
305
2099
1.76
12.33
5.9
4.1
36.37
36.82
g/l
0.77
284
1964
384
2831
1.73
12.06
6.9
5.2
8.73
9.59
umol/l
1.81
361
2678
269
1797
1.77
11.98
4.0
3.0
2.34
2.35
mmol/l
0.15
243
1636
134
719
2.05
11.70
4.0
3.2
0.80
0.82
mmol/l
2.31
128
686
459
3590
1.71
11.30
10.5
8.1
3.89
3.92
e9/l
0.12
412
3165
637
5491
2.02
11.26
5.7
4.3
14.63
14.25
pmol/l
3.88
614
5169
357
2613
1.69
11.25
2.7
2.2
75.74
75.39
nmol/l
0.08
332
2425
143
832
1.89
9.77
3.1
2.8
22.10
183.15
ng/l
3.13
91
434
86
424
2.16
9.31
9.1
6.4
104.98
104.72
mmol/l
0.17
86
424
286
2093
1.59
8.29
3.5
2.8
28.01
27.44
u/l
0.14
279
2001
273
1978
1.60
8.25
2.0
1.7
92.35
99.34
pmol/l
1.51
147
1051
390
3069
1.56
8.21
7.6
5.4
30.32
29.74
%
0.53
378
2902
94
504
1.99
8.12
3.8
3.4
4.52
4.59
pmol/l
0.25
83
453
66
311
2.23
7.99
1.5
1.6
—
—
—
0
0
542
4624
1.61
7.81
5.3
3.8
11.25
9.67
mm/h
2.38
513
4342
120
708
1.83
7.76
1.9
1.7
—
—
—
0
0
28
86
3.34
7.72
2.9
2.4
—
—
—
0
0
384
3038
1.54
7.71
7.2
5.3
56.36
56.38
%
0.01
372
2863
387
3075
1.53
7.56
5.4
3.7
6.27
6.25
mmol/l
0.07
362
2765
264
1934
1.56
7.45
8.9
6.4
1.11
1.07
inr
0.42
73
646
680
6208
1.96
7.20
6.5
4.9
1.68
1.74
mu/l
0.82
660
5900
130
808
1.74
7.02
2.2
2.2
1.21
1.01
e6/l
0.27
70
432
66
329
2.10
6.95
3.5
3.3
2.11
1.96
mmol/l
0.14
54
264
83
451
1.94
6.90
1.7
1.6
—
—
—
0
0
216
1544
1.56
6.66
3.2
2.6
28.44
55.75
e6/l
1.11
157
1148
199
1403
1.57
6.50
3.0
2.5
0.16
0.34
e6/l
2.22
137
1035
18
34
5.40
6.49
2.8
2.3
—
—
—
0
0
103
612
1.79
6.48
2.5
2.2
22.61
24.22
%
0.51
90
522
236
1731
1.53
6.44
2.5
2.3
84.13
55.98
u/l
0.54
217
1610
48
219
2.27
6.30
4.8
3.1
1.09
1.34
mmol/l
0.22
34
162
135
872
1.67
6.29
2.4
2.9
697.07
581.49
ng/l
0.20
117
713
159
1074
1.61
6.20
1.6
1.4
19.63
21.60
nmol/l
1.19
145
947
23
72
3.26
6.19
2.9
1.8
4.19
5.13
mmol/24h
0.83
23
65
103
621
1.76
6.16
3.0
2.4
4.25
5.52
umol/l
1.62
86
521
680
6267
1.86
6.13
15.7
9.5
3.90
3.90
mmol/l
0.08
666
6085
678
6246
1.84
6.07
15.6
9.5
139.65
139.64
mmol/l
0.06
664
6080
19
53
3.65
6.07
2.2
4.1
14.43
21.17
mu/l
0.80
19
53
81
460
1.85
5.90
1.8
1.6
—
—
—
0
0
111
692
1.71
5.89
2.3
2.1
2.51
2.46
g/l
0.38
102
636
116
748
1.65
5.42
2.7
2.3
3.19
4.65
e6/l
1.01
55
371
127
840
1.62
5.36
3.1
2.3
2.43
2.42
mmol/l
0.48
110
742
189
1368
1.51
5.36
1.3
1.3
21.10
24.85
iu/ml
0.24
64
466
485
4194
1.44
5.27
4.6
3.8
124.20
680.73
e6/l
—
5
49
183
1323
1.51
5.20
1.2
1.3
19.49
12.27
u/ml
0.52
68
544
68
383
1.85
5.09
9.6
7.3
0.66
1.10
mmol/l
0.32
61
289
25
94
2.72
4.95
1.6
1.2
—
—
—
0
0
25
94
2.72
4.95
1.6
1.2
—
—
—
0
0
152
1070
1.53
4.87
2.8
2.3
8.10
9.18
e6/l
0.29
128
955
645
5937
1.59
4.85
12.9
8.2
90.89
91.15
ml/min/173m2
0.11
545
4818
200
1497
1.46
4.73
1.9
1.6
1.46
1.32
mmol/l
1.32
182
1301
177
1296
1.48
4.68
2.8
2.2
3599.17
4167.65
umol/l
0.08
159
1163
191
1420
1.46
4.67
2.0
2.0
133.87
133.05
u/l
0.01
184
1350
27
109
2.53
4.67
1.3
1.2
—
—
—
0
0
187
1397
1.45
4.44
3.7
3.0
7.17
7.54
mmol/l
0.53
163
1229
12
24
5.06
4.33
1.7
1.2
64.95
69.92
nmol/24h
0.16
12
24
44
229
1.98
4.20
1.3
1.3
—
—
—
0
0
114
782
1.54
4.09
2.4
2.1
13.62
14.75
umol/l
1.05
109
726
163
1209
1.44
3.99
4.5
3.7
12.81
10.64
mg/mmol
0.11
93
729
67
408
1.70
3.90
3.5
4.1
6.99
21.03
ug/l
0.59
48
304
374
3190
1.34
3.87
4.9
4.2
0.00
0.00
estimate
0.50
65
615
376
3220
1.33
3.74
3.7
3.1
0.00
0.01
estimate
0.80
65
606
214
1691
1.37
3.60
2.4
2.6
13.55
23.89
ng/l
1.25
103
781
44
243
1.86
3.56
2.8
1.8
—
—
—
0
0
86
572
1.57
3.55
5.2
4.6
—
—
—
0
0
181
1395
1.39
3.54
2.4
2.0
—
—
—
0
0
49
281
1.80
3.52
1.6
1.8
—
—
—
0
0
46
259
1.83
3.51
1.6
1.4
67.37
132.94
pmol/l
0.78
46
253
80
525
1.59
3.49
2.2
2.3
53.80
34.60
u/l
0.38
70
436
710
6788
1.77
3.48
11.9
8.3
25.05
23.48
u/l
1.21
700
6596
683
6470
1.58
3.43
15.6
10.0
18.61
18.59
mg/l
0.01
564
4906
104
728
1.50
3.40
1.6
1.6
1154.40
1172.19
nmol/l
0.07
86
561
39
211
1.89
3.37
1.3
1.5
—
—
—
0
0
7
10
7.05
3.37
2.9
3.0
—
—
—
0
0
367
3190
1.29
3.06
3.8
3.1
0.00
0.00
estimate
0.50
66
640
7
12
5.88
3.02
3.4
2.4
71.16
104.66
ug/l
—
7
12
633
5941
1.41
2.98
4.2
3.5
5.58
5.60
mmol/l
0.20
606
5579
41
236
1.78
2.95
3.0
1.7
1.16
1.19
g/l
0.32
41
221
18
77
2.37
2.83
1.3
1.2
—
—
—
0
0
59
883
0.64
2.78
1.5
1.5
—
—
—
0
0
127
959
1.39
2.78
2.3
2.4
143.25
91.85
ug/g
0.86
103
748
17
73
2.36
2.66
1.0
1.1
—
—
—
0
0
67
452
1.53
2.64
4.0
2.1
68.17
80.21
ml/min/173m2
1.17
27
163
36
207
1.78
2.62
1.9
2.0
—
—
—
0
0
12
42
2.89
2.55
1.8
1.3
—
—
—
0
0
176
1418
1.31
2.52
2.2
2.1
2.81
2.66
mg/l
0.39
151
1228
39
236
1.69
2.40
1.3
1.3
33.29
18.70
u/ml
—
7
14
30
509
0.57
2.38
1.4
1.5
—
—
—
0
0
36
214
1.72
2.36
1.3
1.3
3.70
2.28
u/ml
—
6
24
35
207
1.72
2.34
1.6
1.6
0.30
0.32
iu/ml
—
9
33
214
1787
1.28
2.32
1.4
1.3
1.53
1.76
u/ml
0.11
57
509
496
4564
1.25
2.26
3.0
2.7
36.87
34.27
u/l
0.42
479
4378
32
187
1.74
2.24
1.8
1.9
—
—
—
0
0
183
1505
1.29
2.23
1.8
1.4
2.03
2.11
g/l
0.30
107
961
36
218
1.68
2.23
1.2
1.3
2.01
12.94
u/ml
—
7
44
26
445
0.57
2.15
1.5
1.5
—
—
—
0
0
10
36
2.80
2.14
1.0
1.0
—
—
—
0
0
23
123
1.90
2.13
3.8
3.7
3.31
4.29
e9/l
2.41
23
123
202
1692
1.26
2.12
4.3
3.4
0.00
0.00
estimate
1.08
64
617
86
639
1.39
2.09
2.0
2.1
2622.76
6234.08
u/l
1.17
38
268
25
140
1.81
2.03
1.2
1.4
278.69
232.22
u/ml
0.30
16
96
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
83
2.07
2.02
3.8
5.8
0.29
0.41
u/ml
0.97
12
46
80
591
1.40
2.02
3.6
3.3
34.27
32.42
%
0.75
70
431
37
234
1.61
1.97
3.2
2.4
0.07
0.15
e6/l
1.29
37
221
23
127
1.84
1.96
4.0
4.0
52.83
57.71
%
1.38
23
127
8
27
2.98
1.94
3.0
1.3
1.66
2.43
nmol/l
—
8
20
5
12
4.19
1.82
1.4
1.1
8.80
15.58
u/l
—
5
12
8
29
2.78
1.79
1.3
1.3
—
—
—
0
0
69
509
1.39
1.78
2.7
2.3
11.71
27.07
au/ml
—
7
47
15
74
2.05
1.76
1.4
1.6
—
—
—
0
0
25
147
1.72
1.76
1.3
1.3
—
—
—
0
0
6
18
3.35
1.75
3.3
3.1
—
—
—
0
0
6
18
3.35
1.75
1.2
1.1
—
—
—
0
0
12
54
2.24
1.74
1.3
1.1
—
60.33
—
0
6
7
24
2.93
1.72
1.7
1.4
9.26
8.09
ug/l
—
7
24
335
3013
1.20
1.72
2.6
2.4
—
—
—
0
0
13
61
2.15
1.72
1.3
1.3
—
—
—
0
0
11
48
2.31
1.71
1.6
1.4
—
—
—
0
0
72
539
1.37
1.71
1.4
1.3
88.62
183.48
u/ml
0.91
67
501
40
268
1.52
1.69
1.8
1.6
—
—
—
0
0
176
1489
1.24
1.67
1.9
1.8
0.80
0.78
mg/l
0.07
129
1113
569
5390
1.23
1.63
5.2
4.1
38.08
37.70
mmol/mol
0.46
535
5094
63
835
0.73
1.59
1.6
1.5
—
—
—
0
0
42
596
0.69
1.58
1.4
1.4
—
—
—
0
0
20
115
1.76
1.54
3.8
2.2
442.21
180.75
ug/l
0.41
15
101
7
27
2.61
1.51
1.6
1.4
—
—
—
0
0
31
203
1.55
1.48
2.8
2.2
95.32
96.46
%
0.10
31
194
378
3469
1.18
1.47
3.0
2.8
78.38
64.61
ug/l
1.08
361
3285
32
471
0.67
1.46
1.4
1.4
—
—
—
0
0
32
470
0.67
1.45
1.4
1.4
—
—
—
0
0
32
470
0.67
1.45
1.4
1.4
—
—
—
0
0
125
1035
1.25
1.44
1.7
1.6
412.46
61269576.21
pmol/l
2.30
109
914
12
59
2.05
1.44
1.2
1.3
485.75
401.29
pmol/l
0.14
12
53
32
469
0.67
1.44
1.4
1.4
—
—
—
0
0
6
22
2.74
1.43
2.0
1.6
15.77
32.33
ug/l
—
6
22
24
374
0.63
1.43
1.8
1.8
—
—
—
0
0
15
81
1.87
1.41
2.2
1.7
15.42
16.74
%
—
10
36
12
61
1.98
1.33
1.2
1.2
—
—
—
0
0
615
5911
1.22
1.32
3.9
3.2
1.28
1.20
mmol/l
2.34
595
5609
6
24
2.51
1.30
1.0
1.3
—
—
—
0
0
12
62
1.95
1.28
1.2
1.2
—
—
—
0
0
12
62
1.95
1.28
3.6
1.5
8.73
7.85
u/ml
0.09
12
62
10
48
2.10
1.28
1.5
1.4
—
—
—
0
0
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
33
229
1.46
1.24
1.0
1.1
3.96
5.79
u/ml
—
5
38
53
403
1.34
1.19
1.3
1.3
257.95
233.35
miu/ml
0.19
19
207
6
26
2.32
1.19
1.0
1.1
—
—
—
0
0
6
26
2.32
1.19
2.8
3.1
—
136.13
—
0
6
213
1896
1.17
1.16
1.7
1.6
—
—
—
0
0
28
192
1.48
1.13
1.2
1.2
—
—
—
0
0
157
1366
1.19
1.12
4.1
3.3
1.02
1.02
kg/l
1.06
23
186
60
473
1.29
1.07
1.4
1.5
—
—
—
0
0
19
121
1.58
1.06
1.1
1.4
—
—
—
0
0
14
82
1.72
1.05
1.1
1.1
—
—
—
0
0
13
75
1.75
1.03
1.7
1.7
—
—
—
0
0
14
83
1.70
1.02
2.2
1.3
—
—
—
0
0
9
49
1.85
0.99
1.3
1.2
—
—
—
0
0
273
2505
1.14
0.97
3.8
3.1
—
—
—
0
0
17
108
1.59
0.97
1.8
1.6
—
—
—
0
0
10
54
1.86
0.97
1.0
1.2
—
—
—
0
0
7
37
1.90
0.94
1.7
2.1
—
—
—
0
0
9
52
1.74
0.92
1.4
1.8
—
—
—
0
0
27
193
1.41
0.91
1.2
1.2
6.80
53.43
u/ml
—
6
19
27
193
1.41
0.91
1.2
1.2
—
—
—
0
0
17
110
1.56
0.91
1.8
1.6
—
—
—
0
0
23
324
0.70
0.90
1.6
2.0
—
—
—
0
0
11
63
1.76
0.90
1.2
1.1
—
—
—
0
0
28
381
0.72
0.90
1.3
1.7
3.36
3.36
mg/l
0.00
23
263
11
64
1.73
0.86
1.7
1.3
—
—
—
0
0
24
170
1.43
0.86
1.5
1.3
338.87
332.66
ug/g
0.04
15
87
8
44
1.83
0.86
1.5
1.9
—
—
—
0
0
643
6265
1.18
0.86
4.5
3.8
2.91
2.92
mmol/l
0.07
610
5950
8
137
0.58
0.84
1.4
1.9
—
—
—
0
0
10
57
1.76
0.84
1.7
1.4
—
—
—
0
0
10
57
1.76
0.84
1.7
1.4
—
—
—
0
0
29
214
1.37
0.83
1.4
1.5
—
—
—
0
0
568
5492
1.14
0.81
3.9
3.7
—
—
—
0
0
24
328
0.72
0.81
1.5
1.5
—
—
—
0
0
8
47
1.71
0.81
1.8
1.4
1.09
0.93
g/l
—
8
47
6
34
1.77
0.76
1.0
1.1
873.33
1682.41
miu/ml
—
6
34
11
67
1.65
0.75
1.0
1.5
—
—
—
0
0
636
6207
1.16
0.75
4.4
3.5
4.93
4.88
mmol/l
0.62
615
5937
5
25
2.01
0.72
1.0
1.0
—
—
—
0
0
56
463
1.23
0.72
3.3
2.6
—
—
—
0
0
30
229
1.32
0.72
1.8
2.0
5.15
4.92
iu/l
—
10
96
11
68
1.63
0.72
1.1
1.5
—
—
—
0
0
11
68
1.63
0.72
1.1
1.5
—
—
—
0
0
58
483
1.22
0.70
1.6
1.5
—
—
—
0
0
7
41
1.71
0.70
1.1
1.2
—
—
—
0
0
16
110
1.46
0.69
1.1
1.1
—
—
—
0
0
16
111
1.45
0.66
1.2
1.1
121.88
116.13
%
0.32
16
100
127
1407
0.88
0.62
2.0
2.0
—
—
—
0
0
11
71
1.56
0.62
2.1
1.4
—
—
—
0
0
20
147
1.37
0.62
1.2
1.6
—
—
—
0
0
632
6185
1.13
0.62
4.3
3.5
1.60
1.57
mmol/l
1.26
611
5887
5
30
1.67
0.61
1.0
1.1
—
—
—
0
0
8
52
1.54
0.59
2.3
1.5
—
—
—
0
0
10
64
1.57
0.58
1.6
1.4
—
—
—
0
0
13
89
1.47
0.58
1.1
1.1
—
—
—
0
0
193
2079
0.90
0.58
1.6
1.5
—
—
—
0
0
12
81
1.49
0.57
1.1
1.2
—
—
—
0
0
6
36
1.67
0.56
1.5
1.1
126.00
113.61
%
—
6
28
10
65
1.55
0.55
1.1
1.5
—
—
—
0
0
10
65
1.55
0.55
1.1
1.5
—
—
—
0
0
10
65
1.55
0.55
1.1
1.5
—
—
—
0
0
71
810
0.86
0.54
1.5
1.7
—
—
—
0
0
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
6
39
1.54
0.53
3.2
2.3
—
—
—
0
0
6
39
1.54
0.53
1.2
1.7
—
64.60
%
—
0
5
6
39
1.54
0.53
1.0
1.1
104.67
86.13
%
—
6
31
12
83
1.45
0.52
1.8
1.6
—
—
—
0
0
12
83
1.45
0.52
1.8
1.6
—
—
—
0
0
737
7314
1.32
0.51
22.4
14.9
4.41
4.46
e12/l
2.73
726
7174
13
92
1.42
0.50
1.1
1.1
—
—
—
0
0
6
41
1.47
0.50
1.7
1.1
0.37
0.29
g/l
—
6
35
6
41
1.47
0.50
1.7
1.8
—
—
—
0
0
6
41
1.47
0.50
1.7
1.8
—
—
—
0
0
6
41
1.47
0.50
1.7
1.8
—
—
—
0
0
736
7305
1.30
0.48
22.5
14.9
269.92
268.66
e9/l
0.22
724
7177
597
5850
1.10
0.47
17.7
11.8
14.21
14.26
%
0.11
591
5750
53
459
1.17
0.46
1.1
1.0
—
—
—
0
0
7
49
1.43
0.46
2.3
1.4
84.00
67.86
umol/l
—
7
49
9
131
0.68
0.43
1.0
1.1
—
9.73
—
0
14
5
31
1.62
0.43
1.6
1.4
—
—
—
0
0
6
92
0.65
0.42
4.8
6.2
331.00
387.69
umol/l
—
6
80
8
57
1.41
0.42
1.1
1.3
—
—
—
0
0
19
149
1.28
0.42
1.1
1.2
—
—
—
0
0
735
7300
1.26
0.42
22.8
14.8
39.40
39.76
%
1.22
703
6969
14
105
1.34
0.41
1.9
1.8
3690.44
11741.09
e6/l
—
9
81
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
11
79
1.40
0.41
1.1
1.1
99.00
93.07
%
0.37
11
74
53
468
1.14
0.38
1.7
1.7
—
—
—
0
0
9
68
1.33
0.37
1.1
1.1
—
—
—
0
0
10
72
1.39
0.37
1.2
1.2
—
—
—
0
0
10
72
1.39
0.37
1.7
2.0
—
—
—
0
0
10
72
1.39
0.37
1.2
1.2
—
—
—
0
0
27
226
1.20
0.36
1.4
1.3
—
—
—
0
0
6
43
1.40
0.35
1.0
1.3
1.61
1.60
g/l
—
6
43
10
73
1.37
0.34
1.2
1.2
—
—
—
0
0
10
73
1.37
0.34
1.2
1.2
—
—
—
0
0
10
73
1.37
0.34
1.2
1.2
—
—
—
0
0
10
74
1.36
0.32
1.0
1.2
2.60
0.63
u/ml
—
5
35
16
129
1.25
0.30
1.2
1.2
5.00
3.96
u/ml
—
7
53
149
1571
0.94
0.29
2.0
2.1
—
—
—
0
0
8
62
1.29
0.28
1.1
1.1
—
—
—
0
0
8
67
1.20
0.26
4.8
3.4
17.19
73.71
u/ml
—
8
67
25
216
1.16
0.26
1.2
1.1
—
—
—
0
0
15
123
1.22
0.25
1.1
1.1
—
—
—
0
0
10
125
0.80
0.23
2.3
1.6
—
—
—
0
0
11
88
1.25
0.22
1.1
1.1
—
—
—
0
0
5
42
1.19
0.21
1.8
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
98
1035
0.94
0.21
1.8
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
9
112
0.80
0.20
1.3
1.5
—
—
—
0
0
16
138
1.16
0.17
1.0
1.1
1.92
2.53
u/ml
—
6
70
10
82
1.22
0.17
2.2
2.1
—
—
—
0
0
8
73
1.10
0.15
1.8
1.8
—
—
—
0
0
23
207
1.11
0.15
1.1
1.1
0.39
2.64
u/ml
2.37
13
97
7
89
0.78
0.14
1.0
1.2
—
—
—
0
0
15
132
1.14
0.13
1.2
1.2
11.60
4.50
u/ml
—
5
44
14
124
1.13
0.11
3.5
3.3
14.50
23.74
mg/l
—
6
79
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
48
461
1.04
0.07
1.7
1.5
—
—
—
0
0
13
124
1.05
0.00
1.4
1.4
—
—
—
0
0
87
864
1.01
0.00
1.5
1.5
1.49
1.32
%
2.15
81
785
13
126
1.03
0.00
1.0
1.1
—
—
—
0
0
14
144
0.97
0.00
1.2
1.3
—
—
—
0
0
16
156
1.03
0.00
1.1
1.4
3.93
3.72
mmol/l
0.23
16
143
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.2
7.52
15.16
u/l
—
5
46
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.3
1.9
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_OVARFAIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OVARFAIL | 2.676 [2.14, 3.35] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.077 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 2006 females with E4_OVARFAIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_OVARFAIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | No data |
| 5 | 1.402% | No data |
| 10 | 3.668% | No data |
| 15 | 7.081% | No data |
| 20 | 11.799% | No data |
Relationships between endpoints
↥Index endpoint: E4_OVARFAIL – Primary ovarian failure
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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