Gender identity disorders

F5_GENDER

gender identity disorder: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F64
  • Hospital discharge: ICD-9 3023|302[5-6]
  • Hospital discharge: ICD-8 3023
  • Cause of death: ICD-10 F64
  • Cause of death: ICD-9 3023|302[5-6]
  • Cause of death: ICD-8 3023

2 out of 7 registries used, show all original rules.

527

4. Check minimum number of events

None

527

5. Include endpoints

None

527

6. Filter based on genotype QC (FinnGen only)

527

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F63-F69
Name in latin
Perturbationes identitatis generis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5826 3422 2338
Only index persons 5682 3391 2291
Unadjusted period prevalence (%)
Whole population 0.08 0.10 0.07
Only index persons 0.11 0.12 0.09
Median age at first event (years)
Whole population 22.20 20.84 23.99
Only index persons 22.03 20.81 23.84

-FinnGen-

Key figures

All Female Male
Number of individuals 527 358 169
Unadjusted period prevalence (%) 0.11 0.12 0.07
Median age at first event (years) 25.59 23.39 30.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
453
Matched controls
4530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F64.0
ICD-10 Finland
Transsexualism
+∞
323.0
281
*
F64.9
ICD-10 Finland
Gender identity disorder, unspecified
+∞
323.0
437
*
IBZ08
NOMESCO Finland
Gender identity assessment
+∞
318.8
267
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
57.9
120.6
141
35
121
Kela drug reimbursment
Severe hypofunction of sexual glands
71.8
81.6
92
16
IAB05
NOMESCO Finland
Psychiatric consultation for gender identity assessment
+∞
69.6
65
*
F64.8
ICD-10 Finland
Other gender identity disorders
687.0
62.4
60
*
N05AH04
ATC
quetiapine; oral
6.2
58.8
193
481
G03HA01
ATC
cyproterone; systemic
312.7
55.5
55
*
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
15.6
51.4
87
68
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.7
50.7
177
460
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
7.5
46.1
119
204
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
47.4
35.7
43
10
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
195.0
35.3
36
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
8.0
34.9
84
126
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.9
34.8
63
56
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
7.8
34.3
84
129
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
13.1
33.5
60
52
N06AX16
ATC
venlafaxine; oral
5.1
33.3
119
297
N06AX12
ATC
bupropion; oral
6.1
31.2
92
182
N06AB10
ATC
escitalopram; oral
3.7
31.2
173
649
N06AB03
ATC
fluoxetine; oral
5.3
31.2
105
244
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.9
30.9
94
193
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
322.9
30.2
30
*
N06AX11
ATC
mirtazapine; oral
3.6
30.0
169
638
N06AB06
ATC
sertraline; oral
4.8
30.0
111
285
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
9.1
29.9
65
82
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.5
29.5
119
333
ICZ04
NOMESCO Finland
Preparation of psychiatric treatment plan
287.2
27.0
27
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
6.2
27.0
77
145
F84.5
ICD-10 Finland
Asperger syndrome
16.8
25.1
40
26
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
7.8
24.9
59
85
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
24.9
138
502
F61.0
ICD-10 Finland
Mixed personality disorders
71.5
24.1
27
*
W78
ICPC
Pregnancy
0.1
24.0
13
880
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.6
23.9
64
110
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.1
23.9
14
897
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.0
23.6
68
129
F32.1
ICD-10 Finland
Moderate depressive episode
4.7
23.4
85
210
P09
ICPC
Sexual preference concern
+∞
23.1
22
*
SPAT1379
SPAT
Health check-up of pregnant person
0.1
22.7
6
701
N05AX12
ATC
aripiprazole; systemic
6.6
22.6
60
102
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
14.8
22.2
37
27
N05AX08
ATC
risperidone; systemic
6.0
21.0
60
112
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.4
20.8
116
415
F40.1
ICD-10 Finland
Social phobias
6.1
20.8
59
109
C03DA01
ATC
spironolactone; oral
7.8
20.1
47
66
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.1
20.1
10
729
N05BA04
ATC
oxazepam; oral
3.2
19.9
121
461
N05AH03
ATC
olanzapine; systemic
5.6
19.9
60
120
ZZA50
NOMESCO Finland
Full thickness skin graft
208.7
19.7
20
*
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
12.5
19.6
35
30
SPAT1197
SPAT
Extensive health check-up of expecting family
0.1
19.6
11
734
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.1
19.1
126
505
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
57.6
19.1
22
*
N03AX09
ATC
lamotrigine; oral
5.8
18.9
55
105
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
5.6
18.7
56
111
SPAT1380
SPAT
Postpartum check-up
0.1
18.5
5
578
Z39.2
ICD-10 Finland
Routine postpartum follow-up
0.1
18.2
7
618
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.9
16.9
48
89
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
0.1
16.9
7
585
F64
ICD-10 Finland
Gender identity disorders
+∞
16.8
16
*
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
0.0
16.6
*
391
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.2
16.5
65
172
P76
ICPC
Depressive disorder
3.8
16.5
75
226
G03DC03
ATC
lynestrenol; oral
9.5
16.2
33
37
SPAT1240
SPAT
Therapeutic discussion
2.8
16.0
121
524
P03
ICPC
Feeling depressed
2.7
15.9
126
560
F60.6
ICD-10 Finland
Anxious [avoidant] personality disorder
+∞
15.7
15
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
0.1
15.7
10
622
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
6.2
15.5
42
73
SPAT1243
SPAT
Psychiatric/psychological examination
4.6
15.3
55
133
N06AB04
ATC
citalopram; systemic
3.2
15.0
85
303
W11
ICPC
Contraception oral
0.3
15.0
51
1245
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.2
14.9
47
99
F93.89
ICD-10 Finland
Other childhood emotional disorders
6.4
14.7
39
66
P29
ICPC
Psychological sympt/compl other
3.4
14.6
77
260
N06AX26
ATC
vortioxetine; oral
3.9
14.6
62
176
N06BA04
ATC
methylphenidate; oral
4.3
14.2
54
138
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
8.0
13.9
31
41
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
6.0
13.8
38
68
Z32.1
ICD-10 Finland
Pregnancy confirmed
0.1
13.7
*
441
SPAT1307
SPAT
Psychosocial counselling and guidance
2.7
13.7
111
494
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
26.7
13.5
18
7
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.4
13.2
68
226
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
29.3
13.0
17
6
P01
ICPC
Feeling anxious/nervous/tense
2.2
12.9
161
893
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.2
12.8
11
567
SPAT1389
SPAT
Visit based on need for special support
3.3
12.5
65
217
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.4
12.1
36
71
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
5.6
12.1
35
67
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
6.0
12.0
33
59
IGY99
NOMESCO Finland
Other psychiatric treatment contact
5.1
11.9
37
77
F32
ICD-10 Finland
Depressive episode
3.7
11.7
52
153
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
0.1
11.5
6
431
P74
ICPC
Anxiety disorder/anxiety state
3.4
11.4
58
190
F34.1
ICD-10 Finland
Dysthymia
5.4
11.2
33
65
IEY01
NOMESCO Finland
Psychoeducation, individual
10.0
10.9
21
22
DQW99
NOMESCO Finland
Other operation on larynx
+∞
10.5
10
*
F60.8
ICD-10 Finland
Other specific personality disorders
33.4
10.4
13
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.2
10.3
10
479
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
0.1
10.3
*
333
WX307
NOMESCO Finland
Obstetric epidural analgesia
0.1
10.2
5
378
WX402
NOMESCO Finland
General anaesthesia
2.5
10.1
83
368
N05CF01
ATC
zopiclone; oral
2.6
10.0
75
317
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
12.6
9.9
17
14
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.4
9.8
25
41
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
7.1
9.7
23
34
N06AX05
ATC
trazodone; oral
8.7
9.7
20
24
IGY02
NOMESCO Finland
Psychiatric monitoring contact
4.5
9.5
33
78
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
4.7
9.3
31
70
F31.8
ICD-10 Finland
Other bipolar affective disorders
5.8
9.2
25
45
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
0.1
8.9
*
278
N05AF03
ATC
chlorprothixene; systemic
8.9
8.9
18
21
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
14.4
8.7
14
10
N06AX22
ATC
agomelatine; oral
5.7
8.7
24
44
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
4.6
8.7
29
66
F60.9
ICD-10 Finland
Personality disorder, unspecified
51.0
8.7
10
*
MAX99
NOMESCO Finland
Assistance to normal delivery
0.1
8.6
5
340
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
4.6
8.6
29
67
R49.08
ICD-10 Finland
Other specified dysphonia
10.3
8.6
16
16
P99
ICPC
Psychological disorders other
4.4
8.6
30
72
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.2
8.5
25
50
F33.8
ICD-10 Finland
Other recurrent depressive disorders
11.0
8.3
15
14
N06AX21
ATC
duloxetine; oral
3.1
8.2
43
146
MA3AE
NOMESCO Finland
Combined first trimester screening
0.1
8.2
*
279
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
10.3
8.1
15
15
N05AD01
ATC
haloperidol; systemic
11.1
7.8
14
13
N06AB05
ATC
paroxetine; oral
4.1
7.7
29
75
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.7
7.7
25
56
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
0.4
7.7
36
796
QB2S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in chest
25.5
7.6
10
*
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.4
7.6
29
697
N05AN01
ATC
lithium; oral
7.3
7.5
17
24
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
0.2
7.5
5
304
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.1
7.5
19
32
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
0.0
7.5
*
215
HAC99
NOMESCO Finland
Other mastectomy
81.4
7.4
8
*
SPAT1284
SPAT
Extensive health certificate
3.6
7.4
32
94
IDY25
NOMESCO Finland
Systematic individual therapy, visual arts psychotherapy
+∞
7.3
7
*
F33
ICD-10 Finland
Recurrent depressive disorder
4.8
7.3
23
50
Z37.0
ICD-10 Finland
Single live birth
0.2
7.3
5
302
N05BA01
ATC
diazepam; systemic, rectal
2.8
7.2
45
169
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.1
7.2
38
130
N03AX16
ATC
pregabalin; oral
2.5
7.2
56
243
W90
ICPC
Uncompl labour/delivery livebirth
0.1
7.2
*
230
SPAT1241
SPAT
Extensive assessment of psychosocial situation
4.9
7.1
22
47
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
0.1
7.1
*
252
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
0.1
7.1
*
276
N05AE04
ATC
ziprasidone; systemic
10.3
7.1
13
13
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
7.2
7.1
16
23
R4120
NOMESCO Finland
Occupational therapy
3.9
7.0
27
72
HA1AA
NOMESCO Finland
X-ray mammography
5.6
7.0
19
35
F50.0
ICD-10 Finland
Anorexia nervosa
5.2
6.9
20
40
N05AB03
ATC
perphenazine; systemic, rectal
5.5
6.8
19
36
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.3
6.8
32
101
P80
ICPC
Personality disorder
40.7
6.8
8
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
0.2
6.7
8
343
O80.8
ICD-10 Finland
Other single spontaneous delivery
0.0
6.6
*
192
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.5
6.5
29
88
P86
ICPC
Anorexia nervosa/bulimia
7.6
6.5
14
19
N03AG01
ATC
valproic acid; systemic, rectal
3.4
6.4
29
89
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
8.3
6.4
13
16
HAC20
NOMESCO Finland
Total mastectomy
9.4
6.3
12
13
IER03
NOMESCO Finland
Psychiatric disorder-specific group intervention
18.3
6.3
9
5
RT250
NOMESCO Finland
NA
27.1
6.2
8
*
IGP01
NOMESCO Finland
Psychiatric family contact
5.5
6.2
17
32
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
4.5
6.1
20
46
IBA03
NOMESCO Finland
Psychotherapy evaluation
5.0
6.1
18
37
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
10.2
6.1
11
11
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
0.1
6.0
*
178

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
165
307
7.37
91.00
2.4
1.9
11.0
11.8
nmol/l
0.32
144
279
98
129
9.10
72.53
2.2
1.7
0.3
0.4
nmol/l
0.95
89
114
120
381
3.78
32.58
1.9
1.6
349.7
301.6
mu/l
1.30
112
337
86
269
3.63
23.45
2.0
1.5
5.7
8.4
u/l
2.66
70
220
78
260
3.35
19.12
2.1
1.4
4.6
13.0
iu/l
7.16
65
204
73
248
3.26
17.30
2.2
2.1
—
—
—
0
0
65
1553
0.34
16.02
1.8
1.8
—
—
—
0
0
139
690
2.38
15.76
1.6
1.5
1.4
1.3
mmol/l
0.51
123
622
187
2770
0.50
12.97
2.8
3.6
—
—
—
0
0
93
426
2.44
12.39
2.9
2.1
—
—
—
0
0
87
1658
0.43
11.86
1.4
1.7
—
—
—
0
0
128
2040
0.51
10.03
2.4
2.9
0.0
0.0
estimate
0.00
31
444
142
2178
0.52
9.75
1.8
2.2
—
—
—
0
0
129
2024
0.52
9.42
2.3
2.8
0.0
0.0
estimate
0.00
29
445
129
2018
0.52
9.29
3.1
3.9
0.0
0.0
estimate
0.50
33
459
395
3220
1.91
9.28
3.7
3.6
14.5
14.4
pmol/l
0.21
357
2894
19
677
0.25
9.12
1.2
1.2
—
—
—
0
0
5
332
0.14
8.41
1.0
1.6
—
—
—
0
0
107
1722
0.52
8.12
1.5
1.8
—
—
—
0
0
364
4205
0.57
7.89
7.4
8.8
16.2
20.8
mg/l
2.24
210
3118
168
2357
0.58
7.73
2.3
2.7
49.8
57.4
ug/l
0.97
146
2211
57
1090
0.47
7.09
1.4
1.5
—
—
—
0
0
5
284
0.17
6.58
2.4
1.4
—
—
—
0
0
74
1265
0.52
6.51
2.2
2.4
—
—
—
0
0
460
4920
0.49
6.37
12.2
12.3
138.9
136.5
g/l
3.27
443
4851
460
4919
0.49
6.32
12.1
12.3
6.7
6.8
e9/l
0.03
412
4792
460
4916
0.49
6.17
12.1
12.2
4.7
4.6
e12/l
2.56
415
4790
460
4915
0.50
6.12
12.1
12.2
88.8
88.8
fl
0.09
445
4846
460
4913
0.50
6.03
12.0
12.2
29.6
29.8
pg
0.91
445
4843
132
871
1.69
5.95
2.1
2.4
2.4
2.4
mmol/l
0.12
119
780
460
4906
0.51
5.71
12.1
12.3
269.8
261.2
e9/l
1.47
415
4777
17
46
3.79
5.69
1.4
2.1
—
—
—
0
0
85
503
1.82
5.58
2.3
1.6
—
—
—
0
0
33
698
0.44
5.24
1.6
2.3
254.4
5497.2
u/l
—
6
266
13
32
4.14
4.92
2.8
2.4
—
—
—
0
0
29
124
2.42
4.49
1.2
1.2
—
—
—
0
0
415
4511
0.62
4.44
7.6
7.6
—
—
—
0
0
362
4047
0.66
4.39
9.9
9.9
333.0
334.2
g/l
1.64
356
4007
11
26
4.30
4.37
1.4
3.0
—
—
—
0
0
11
26
4.30
4.37
2.7
6.0
—
—
—
0
0
99
656
1.63
4.30
2.2
1.6
—
—
—
0
0
99
662
1.61
4.14
2.2
1.7
—
—
—
0
0
92
607
1.62
4.06
2.3
1.7
—
—
—
0
0
98
660
1.60
3.97
2.2
1.6
—
—
—
0
0
51
848
0.56
3.87
2.6
2.9
—
—
—
0
0
23
498
0.44
3.86
1.7
2.1
—
—
—
0
0
72
1091
0.61
3.82
1.8
2.1
—
—
—
0
0
138
1808
0.68
3.69
3.2
4.0
—
—
—
0
0
96
655
1.57
3.67
2.2
1.6
—
—
—
0
0
15
373
0.38
3.52
1.3
1.3
—
—
—
0
0
6
6
10.10
3.50
5.0
2.5
—
—
—
0
0
119
863
1.49
3.43
2.5
3.0
9.1
9.1
mmol/l
0.01
94
772
7
224
0.30
3.41
1.6
2.1
—
—
—
0
0
74
1087
0.63
3.40
2.1
2.0
—
—
—
0
0
60
380
1.65
3.11
2.6
2.3
2.4
2.4
mmol/l
0.23
52
333
120
1570
0.69
3.06
2.3
2.6
—
—
—
0
0
77
1097
0.65
3.05
2.6
3.0
0.0
0.0
estimate
1.08
30
442
313
2742
1.35
2.83
3.3
3.2
34.7
36.3
mmol/mol
2.85
293
2601
410
3751
1.42
2.82
4.6
4.1
1.9
1.8
mu/l
1.30
383
3535
96
1288
0.69
2.78
2.8
3.1
31.0
107.5
e6/l
1.60
61
803
76
1065
0.67
2.76
5.1
4.0
—
—
—
0
0
406
4346
0.71
2.61
8.8
8.8
41.9
40.7
%
7.29
313
3706
69
974
0.66
2.58
1.9
2.0
2.9
2.6
mg/l
0.38
50
834
6
11
5.50
2.55
1.0
2.4
1.5
2.2
nmol/l
—
6
11
41
647
0.60
2.53
5.3
3.5
—
—
—
0
0
52
774
0.64
2.50
1.7
1.8
0.5
0.8
mg/l
1.98
33
514
68
476
1.49
2.33
1.3
1.4
446.6
15438210.4
pmol/l
0.50
49
434
8
23
3.52
2.27
1.0
1.9
7.3
7.7
nmol/l
—
8
23
114
1428
0.74
2.10
2.1
1.8
—
—
—
0
0
50
336
1.54
2.08
1.6
1.6
1124.6
1134.3
nmol/l
0.02
35
259
209
1790
1.28
2.00
6.8
7.3
0.0
0.0
e9/l
0.48
162
1457
137
1111
1.32
1.98
3.4
4.6
38.5
38.3
g/l
0.17
118
1034
0
53
0.00
1.88
0.0
2.5
—
—
—
0
0
0
53
0.00
1.88
0.0
1.3
—
—
—
0
0
63
848
0.71
1.82
2.4
2.3
45.6
22.1
ng/l
0.32
22
302
0
47
0.00
1.71
0.0
1.3
—
—
—
0
0
101
1245
0.77
1.62
2.0
1.7
—
—
—
0
0
5
14
3.59
1.62
7.0
7.6
—
—
—
0
0
23
369
0.61
1.56
1.3
1.3
—
—
—
0
0
6
142
0.42
1.54
1.8
2.2
0.2
0.2
e6/l
—
6
133
8
167
0.47
1.49
1.3
1.6
—
—
—
0
0
7
28
2.52
1.45
1.4
1.2
—
—
—
0
0
7
154
0.45
1.45
11.1
14.1
117.0
125.8
g/l
—
7
145
77
966
0.76
1.40
2.2
2.4
54.2
56.0
u/l
0.18
64
892
89
714
1.30
1.39
2.4
3.2
7.4
7.4
ph
0.21
17
141
368
3445
1.23
1.35
3.2
2.7
2.8
2.7
mmol/l
1.14
338
3245
202
2256
0.83
1.28
7.8
7.2
3.9
3.9
e9/l
0.08
170
1974
29
420
0.67
1.28
1.2
1.3
—
—
—
0
0
165
1877
0.82
1.27
4.8
5.8
8.2
8.0
%
0.53
148
1776
364
3415
1.21
1.25
3.1
2.6
1.3
1.4
mmol/l
9.65
336
3236
44
588
0.73
1.24
1.8
2.4
340.7
4450.6
umol/l
1.78
37
539
80
981
0.78
1.23
2.3
2.7
24.3
77.5
e6/l
1.05
57
729
366
3439
1.21
1.23
3.2
2.7
4.5
4.5
mmol/l
0.75
338
3265
7
141
0.49
1.22
1.1
1.1
—
—
—
0
0
11
57
1.95
1.17
1.1
3.5
1.0
1.0
nmol/l
0.06
11
52
0
33
0.00
1.16
0.0
1.2
—
—
—
0
0
0
33
0.00
1.16
0.0
17.9
—
105.2
—
0
25
0
35
0.00
1.15
0.0
2.7
—
5.6
—
0
27
73
895
0.79
1.12
4.3
5.1
1.0
1.1
inr
0.41
43
346
17
104
1.66
1.10
1.3
1.6
—
—
—
0
0
25
359
0.68
1.08
1.1
1.2
—
—
—
0
0
7
33
2.14
1.06
1.9
1.6
—
—
—
0
0
166
1861
0.84
1.05
4.7
5.6
2.6
2.7
%
0.19
149
1739
10
178
0.55
1.05
1.3
1.4
—
—
—
0
0
8
147
0.54
1.05
3.8
2.7
22.1
20.8
s
—
8
129
131
1499
0.83
1.05
4.8
4.5
9.8
10.3
umol/l
0.38
113
1393
182
2021
0.85
1.03
6.6
5.9
0.2
0.2
e9/l
0.46
155
1814
177
1968
0.85
1.01
4.4
5.3
54.9
55.3
%
0.25
159
1864
9
161
0.55
0.99
12.0
13.6
96.3
96.9
%
—
9
150
0
29
0.00
0.98
0.0
2.0
—
6.3
—
0
29
68
554
1.26
0.98
1.3
1.3
18.3
19.3
nmol/l
0.27
58
483
0
30
0.00
0.97
0.0
2.7
—
10.9
—
0
23
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
0
32
0.00
0.95
0.0
3.0
—
—
—
0
0
0
32
0.00
0.95
0.0
18.5
—
11.7
—
0
24
176
1943
0.86
0.90
5.0
5.7
0.5
0.5
e9/l
0.11
147
1725
392
3748
1.18
0.90
10.3
10.2
13.1
13.1
%
0.13
377
3661
177
1951
0.86
0.88
5.0
5.7
0.0
0.0
e9/l
0.12
145
1735
17
111
1.55
0.88
1.0
1.1
—
—
—
0
0
33
434
0.74
0.88
1.8
1.5
—
—
—
0
0
77
908
0.82
0.85
2.4
2.6
—
—
—
0
0
66
790
0.81
0.84
2.2
2.7
102.4
111.7
ug/g
0.05
44
609
182
1995
0.87
0.84
4.5
5.5
31.6
31.0
%
0.39
165
1891
75
884
0.82
0.82
2.4
2.7
0.2
0.2
e6/l
0.15
53
643
55
668
0.80
0.80
2.1
2.3
11.0
9.2
e6/l
0.25
46
589
5
97
0.51
0.78
2.8
1.9
—
—
—
0
0
32
413
0.76
0.76
1.3
1.3
—
—
—
0
0
251
2678
0.88
0.75
3.1
3.3
7.6
7.6
mm/h
0.02
219
2466
162
1777
0.87
0.74
4.7
5.8
0.6
0.6
%
0.15
145
1669
117
1037
1.16
0.73
1.6
1.5
87.0
97.5
pmol/l
1.62
64
574
6
108
0.55
0.73
5.8
6.6
—
—
—
0
0
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
99
867
1.17
0.72
6.0
5.5
—
—
—
0
0
11
68
1.63
0.72
1.2
2.5
—
—
—
0
0
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
28
363
0.76
0.70
1.6
2.2
22.6
24.7
%
0.35
23
322
192
2069
0.89
0.65
4.8
5.6
2.0
2.0
e9/l
0.38
164
1870
82
937
0.85
0.65
1.5
1.6
—
—
—
0
0
8
127
0.62
0.64
1.4
1.4
—
—
—
0
0
8
130
0.61
0.64
1.0
1.2
—
—
—
0
0
386
3724
1.14
0.63
7.3
7.9
139.7
139.4
mmol/l
1.95
362
3578
53
627
0.83
0.62
2.2
2.4
556.8
587.7
mosm/kgh2o
0.39
39
545
42
344
1.24
0.62
1.2
1.2
—
—
—
0
0
33
410
0.79
0.61
1.5
2.1
2.6
2.6
g/l
0.03
26
372
0
20
0.00
0.60
0.0
1.2
—
442.7
—
0
20
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
2.6
—
12.0
—
0
21
21
157
1.35
0.60
1.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
11
162
0.67
0.59
4.5
8.4
25.9
24.3
mmol/l
0.65
11
162
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
6
35
1.72
0.58
2.0
1.7
—
—
—
0
0
26
329
0.78
0.57
1.2
1.4
—
—
—
0
0
5
88
0.56
0.56
1.2
1.2
—
—
—
0
0
5
88
0.56
0.56
13.0
17.3
—
—
—
0
0
33
404
0.80
0.55
2.1
3.3
1.0
1.5
ug/l
1.31
25
370
19
250
0.75
0.55
8.6
8.5
103.5
105.0
mmol/l
0.45
19
244
36
435
0.81
0.54
1.5
2.6
15.6
961.8
ng/l
1.38
13
191
24
187
1.30
0.53
3.3
2.4
1.2
1.2
mmol/l
0.02
18
161
175
1874
0.90
0.52
3.1
4.3
6.0
6.1
mmol/l
0.57
160
1623
18
135
1.35
0.51
2.1
1.5
—
—
—
0
0
36
431
0.82
0.50
2.8
3.2
—
—
—
0
0
346
3339
1.11
0.50
3.2
2.5
5.6
5.5
mmol/l
0.70
314
3090
33
272
1.23
0.48
3.5
3.5
4.9
4.8
pmol/l
0.35
27
241
7
47
1.50
0.47
1.0
1.0
—
—
—
0
0
119
1092
1.12
0.46
3.8
5.8
1.2
1.2
mmol/l
0.63
104
990
5
82
0.61
0.46
1.0
1.1
—
—
—
0
0
10
69
1.46
0.44
3.2
2.6
—
—
—
0
0
7
51
1.38
0.44
1.1
1.1
—
—
—
0
0
110
1194
0.90
0.42
1.4
1.4
2.2
2.0
g/l
0.88
52
765
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
1.4
—
0
15
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
30
251
1.21
0.40
2.4
2.2
—
20.7
—
0
19
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.1
—
106.2
—
0
18
0
18
0.00
0.40
0.0
3.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.1
—
3.8
—
0
18
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
33
386
0.85
0.38
2.8
1.9
—
—
—
0
0
51
576
0.87
0.38
1.3
1.5
—
—
—
0
0
20
246
0.81
0.38
1.0
1.1
—
—
—
0
0
129
1379
0.91
0.37
1.5
1.4
1.1
1.8
u/ml
0.65
26
358
44
501
0.87
0.37
3.4
4.7
4.8
17.3
mg/mmol
2.37
23
366
15
189
0.79
0.35
2.9
3.0
—
—
—
0
0
42
477
0.87
0.34
2.4
3.9
46.7
110.9
mg/l
1.37
21
349
382
3734
1.08
0.34
7.4
7.9
3.8
3.9
mmol/l
5.13
358
3570
28
238
1.19
0.33
1.0
1.1
—
—
—
0
0
10
74
1.36
0.32
1.1
1.0
—
—
—
0
0
14
174
0.80
0.30
1.8
1.7
—
—
—
0
0
128
1217
1.07
0.24
3.5
6.3
1.2
1.2
mmol/l
0.29
101
1028
14
169
0.82
0.24
1.1
1.4
145.0
197.8
u/ml
—
8
93
14
169
0.82
0.24
1.0
1.1
11.0
9.8
u/ml
—
9
100
27
306
0.88
0.23
1.1
1.1
—
120.7
—
0
7
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
42
1.19
0.21
1.8
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
6.3
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
12
145
0.82
0.21
1.5
2.2
28.6
24.9
u/ml
0.23
12
140
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
200
1940
1.05
0.19
2.8
2.3
—
—
—
0
0
23
258
0.89
0.18
1.1
1.2
—
—
—
0
0
54
578
0.93
0.18
1.3
1.2
23.3
8.4
u/ml
0.42
15
234
5
69
0.72
0.17
12.4
5.2
—
—
—
0
0
9
78
1.16
0.15
1.3
1.0
—
—
—
0
0
14
161
0.87
0.15
1.0
1.1
0.2
1.9
u/ml
—
9
72
251
2460
1.04
0.15
5.5
5.9
78.0
70.3
u/l
2.10
219
2299
16
180
0.89
0.13
1.4
1.3
—
—
—
0
0
330
3256
1.04
0.13
2.8
2.5
1.3
1.2
mmol/l
1.54
305
3083
42
447
0.93
0.13
1.2
1.2
108.7
127.3
iu/ml
0.13
12
164
18
200
0.90
0.12
5.3
8.6
1.3
1.3
mmol/l
0.11
18
189
10
85
1.18
0.12
1.4
1.3
—
—
—
0
0
13
114
1.14
0.12
1.1
1.4
—
—
—
0
0
34
363
0.93
0.11
3.3
2.8
5.5
6.8
umol/l
0.33
26
295
66
688
0.95
0.11
1.7
2.0
162.7
272.4
u/l
0.48
54
663
18
198
0.91
0.11
6.1
10.8
—
—
—
0
0
10
115
0.87
0.10
1.0
1.1
0.6
9.5
u/ml
—
5
52
25
269
0.93
0.10
6.4
4.3
0.6
0.8
%
—
8
68
12
135
0.89
0.10
1.2
1.1
0.5
5.9
u/ml
—
5
53
120
1227
0.97
0.08
3.9
5.7
—
—
—
0
0
24
256
0.93
0.08
4.3
3.9
0.3
0.3
%
—
7
49
22
235
0.93
0.07
1.3
1.8
1.1
1.1
g/l
0.03
17
216
8
94
0.85
0.06
1.3
3.1
27.8
57.9
ng/l
—
8
82
14
129
1.09
0.05
1.0
1.1
—
—
—
0
0
48
466
1.03
0.05
1.3
1.2
—
—
—
0
0
37
357
1.04
0.05
1.3
1.5
—
—
—
0
0
10
91
1.10
0.04
1.0
1.2
3.6
3.6
mmol/l
—
10
85
23
241
0.95
0.04
2.0
3.3
—
—
—
0
0
18
190
0.95
0.04
1.1
1.1
6.3
1.4
u/ml
—
8
75
26
250
1.04
0.03
6.2
4.5
0.0
0.1
%
—
8
52
23
239
0.96
0.02
1.8
2.2
0.4
0.7
ug/l
2.50
11
119
25
259
0.96
0.02
6.4
4.4
0.0
0.1
%
—
8
61
10
93
1.08
0.02
2.5
4.2
57.4
54.0
%
—
10
93
10
93
1.08
0.02
2.5
4.1
4.2
3.5
e9/l
—
10
93
56
552
1.02
0.01
1.3
1.4
218.2
561.2
titre
3.44
11
101
62
628
0.99
0.01
2.3
2.2
—
—
—
0
0
60
593
1.01
0.01
1.4
1.2
15.5
16.9
iu/ml
0.12
15
166
21
214
0.98
0.00
2.6
5.1
—
—
—
0
0
10
102
0.98
0.00
1.2
1.4
435.8
484.8
mg/l
—
10
97
21
208
1.01
0.00
2.5
5.0
2.7
1.2
mmol/l
0.75
16
157
11
111
0.99
0.00
2.5
4.3
—
—
—
0
0
88
879
1.00
0.00
2.1
2.8
1.0
1.0
kg/l
—
5
120
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
1.2
—
0
6
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.8
—
22.9
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
2.6
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
37.0
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
1.3
—
0
5
0
8
0.00
0.00
0.0
4.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint F5_GENDER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_GENDER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: F5_GENDER – Gender identity disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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