gender identity disorder: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
527 |
4. Check minimum number of eventsNone |
527 |
5. Include endpointsNone |
527 |
6. Filter based on genotype QC (FinnGen only) |
527 |
Control definitions (FinnGen only)
- Control exclude
- F5_PERSOBEH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F63-F69
- Name in latin
- Perturbationes identitatis generis
Similar endpoints
↥List of similar endpoints to
Gender identity disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of adult personality and behaviour
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5826 | 3422 | 2338 |
| Only index persons | 5682 | 3391 | 2291 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.07 |
| Only index persons | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 22.20 | 20.84 | 23.99 |
| Only index persons | 22.03 | 20.81 | 23.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 527 | 358 | 169 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.07 |
| Median age at first event (years) | 25.59 | 23.39 | 30.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 453
- Matched controls
- 4530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F64.9
ICD-10 Finland
Gender identity disorder, unspecified
+∞
323.0
437
*
F64.0
ICD-10 Finland
Transsexualism
+∞
323.0
281
*
IBZ08
NOMESCO Finland
Gender identity assessment
+∞
318.8
267
*
ZY010
NOMESCO Finland
Hospital outpatient
24.4
153.1
235
191
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
57.9
120.6
141
35
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
18.3
120.6
204
194
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
18.8
92.2
149
115
121
Kela drug reimbursment
Severe hypofunction of sexual glands
71.8
81.6
92
16
Z3231
NOMESCO Finland
Registered nurse
7.1
74.8
239
618
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
13.3
71.6
134
139
IAB05
NOMESCO Finland
Psychiatric consultation for gender identity assessment
+∞
69.6
65
*
Z2445
NOMESCO Finland
Psychologist
11.1
69.0
143
181
F64.8
ICD-10 Finland
Other gender identity disorders
687.0
62.4
60
*
ZYC01
NOMESCO Finland
Remote contact by phone
13.6
60.5
110
104
N05AH04
ATC
quetiapine; oral
6.2
58.8
193
481
ZYC02
NOMESCO Finland
Remote contact by video link
634.4
58.0
56
*
G03HA01
ATC
cyproterone; systemic
312.7
55.5
55
*
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
17.9
55.0
88
60
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
15.6
51.4
87
68
Z2221
NOMESCO Finland
Medical doctor
5.2
51.1
203
612
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.7
50.7
177
460
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
7.5
46.1
119
204
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
48.8
43.3
52
12
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
9.5
41.2
89
113
Z2446
NOMESCO Finland
Social worker
7.2
39.2
103
178
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
47.4
35.7
43
10
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
195.0
35.3
36
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
8.0
34.9
84
126
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.9
34.8
63
56
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
7.8
34.3
84
129
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
13.1
33.5
60
52
N06AX16
ATC
venlafaxine; oral
5.1
33.3
119
297
N06AX12
ATC
bupropion; oral
6.1
31.2
92
182
N06AB10
ATC
escitalopram; oral
3.7
31.2
173
649
N06AB03
ATC
fluoxetine; oral
5.3
31.2
105
244
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
18.4
30.9
48
29
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.9
30.9
94
193
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
7.3
30.7
78
126
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
322.9
30.2
30
*
N06AX11
ATC
mirtazapine; oral
3.6
30.0
169
638
N06AB06
ATC
sertraline; oral
4.8
30.0
111
285
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
9.1
29.9
65
82
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.5
29.5
119
333
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
10.5
28.1
56
60
ICZ04
NOMESCO Finland
Preparation of psychiatric treatment plan
287.2
27.0
27
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
6.2
27.0
77
145
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.0
26.8
69
113
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
7.4
25.8
64
99
F84.5
ICD-10 Finland
Asperger syndrome
16.8
25.1
40
26
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
7.8
24.9
59
85
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
24.9
138
502
F61.0
ICD-10 Finland
Mixed personality disorders
71.5
24.1
27
*
W78
ICPC
Pregnancy
0.1
24.0
13
880
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.6
23.9
64
110
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.1
23.9
14
897
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.0
23.6
68
129
F32.1
ICD-10 Finland
Moderate depressive episode
4.7
23.4
85
210
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
23.6
23.4
33
15
P09
ICPC
Sexual preference concern
+∞
23.1
22
*
SPAT1379
SPAT
Health check-up of pregnant person
0.1
22.7
6
701
ZYY01
NOMESCO Finland
Contact between professionals
47.7
22.6
27
6
N05AX12
ATC
aripiprazole; systemic
6.6
22.6
60
102
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
14.8
22.2
37
27
ZYY79
NOMESCO Finland
Other indirect service without contact with patient
52.7
21.3
25
5
N05AX08
ATC
risperidone; systemic
6.0
21.0
60
112
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.4
20.8
116
415
F40.1
ICD-10 Finland
Social phobias
6.1
20.8
59
109
C03DA01
ATC
spironolactone; oral
7.8
20.1
47
66
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.1
20.1
10
729
N05BA04
ATC
oxazepam; oral
3.2
19.9
121
461
N05AH03
ATC
olanzapine; systemic
5.6
19.9
60
120
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
30.5
19.9
26
9
ZZA50
NOMESCO Finland
Full thickness skin graft
208.7
19.7
20
*
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
12.5
19.6
35
30
SPAT1197
SPAT
Extensive health check-up of expecting family
0.1
19.6
11
734
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
33.0
19.5
25
8
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.1
19.1
126
505
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
57.6
19.1
22
*
N03AX09
ATC
lamotrigine; oral
5.8
18.9
55
105
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
5.6
18.7
56
111
SPAT1380
SPAT
Postpartum check-up
0.1
18.5
5
578
Z39.2
ICD-10 Finland
Routine postpartum follow-up
0.1
18.2
7
618
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
15.6
17.4
28
19
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.9
16.9
48
89
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
16.9
149
708
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
0.1
16.9
7
585
F64
ICD-10 Finland
Gender identity disorders
+∞
16.8
16
*
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
0.0
16.6
*
391
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.2
16.5
65
172
P76
ICPC
Depressive disorder
3.8
16.5
75
226
G03DC03
ATC
lynestrenol; oral
9.5
16.2
33
37
SPAT1240
SPAT
Therapeutic discussion
2.8
16.0
121
524
P03
ICPC
Feeling depressed
2.7
15.9
126
560
F60.6
ICD-10 Finland
Anxious [avoidant] personality disorder
+∞
15.7
15
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
0.1
15.7
10
622
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
6.2
15.5
42
73
SPAT1243
SPAT
Psychiatric/psychological examination
4.6
15.3
55
133
N06AB04
ATC
citalopram; systemic
3.2
15.0
85
303
W11
ICPC
Contraception oral
0.3
15.0
51
1245
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.2
14.9
47
99
F93.89
ICD-10 Finland
Other childhood emotional disorders
6.4
14.7
39
66
P29
ICPC
Psychological sympt/compl other
3.4
14.6
77
260
N06AX26
ATC
vortioxetine; oral
3.9
14.6
62
176
N06BA04
ATC
methylphenidate; oral
4.3
14.2
54
138
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
8.0
13.9
31
41
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
6.0
13.8
38
68
Z32.1
ICD-10 Finland
Pregnancy confirmed
0.1
13.7
*
441
SPAT1307
SPAT
Psychosocial counselling and guidance
2.7
13.7
111
494
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
26.7
13.5
18
7
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.4
13.2
68
226
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
29.3
13.0
17
6
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
9.4
12.9
26
29
P01
ICPC
Feeling anxious/nervous/tense
2.2
12.9
161
893
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.2
12.8
11
567
SPAT1389
SPAT
Visit based on need for special support
3.3
12.5
65
217
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.4
12.1
36
71
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
5.6
12.1
35
67
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
6.0
12.0
33
59
IGY99
NOMESCO Finland
Other psychiatric treatment contact
5.1
11.9
37
77
F32
ICD-10 Finland
Depressive episode
3.7
11.7
52
153
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
0.1
11.5
6
431
P74
ICPC
Anxiety disorder/anxiety state
3.4
11.4
58
190
ZXY83
NOMESCO Finland
Social worker in multidisciplinary team
17.6
11.3
17
10
F34.1
ICD-10 Finland
Dysthymia
5.4
11.2
33
65
IEY01
NOMESCO Finland
Psychoeducation, individual
10.0
10.9
21
22
DQW99
NOMESCO Finland
Other operation on larynx
+∞
10.5
10
*
F60.8
ICD-10 Finland
Other specific personality disorders
33.4
10.4
13
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.2
10.3
10
479
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
0.1
10.3
*
333
WX307
NOMESCO Finland
Obstetric epidural analgesia
0.1
10.2
5
378
ZXE20
NOMESCO Finland
More than three and less than five hours
3.3
10.1
52
172
WX402
NOMESCO Finland
General anaesthesia
2.5
10.1
83
368
N05CF01
ATC
zopiclone; oral
2.6
10.0
75
317
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
12.6
9.9
17
14
ZXY52
NOMESCO Finland
2-person team, doctor-psychologist
20.6
9.9
14
7
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.4
9.8
25
41
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
7.1
9.7
23
34
N06AX05
ATC
trazodone; oral
8.7
9.7
20
24
Z3226
NOMESCO Finland
Physiotherapist
2.6
9.6
75
325
IGY02
NOMESCO Finland
Psychiatric monitoring contact
4.5
9.5
33
78
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.7
9.5
41
119
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
4.7
9.3
31
70
F31.8
ICD-10 Finland
Other bipolar affective disorders
5.8
9.2
25
45
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
0.1
8.9
*
278
N05AF03
ATC
chlorprothixene; systemic
8.9
8.9
18
21
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
14.4
8.7
14
10
N06AX22
ATC
agomelatine; oral
5.7
8.7
24
44
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
4.6
8.7
29
66
F60.9
ICD-10 Finland
Personality disorder, unspecified
51.0
8.7
10
*
MAX99
NOMESCO Finland
Assistance to normal delivery
0.1
8.6
5
340
ZXY03
NOMESCO Finland
Occupational therapist
16.7
8.6
13
8
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
4.6
8.6
29
67
R49.08
ICD-10 Finland
Other specified dysphonia
10.3
8.6
16
16
P99
ICPC
Psychological disorders other
4.4
8.6
30
72
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.2
8.5
25
50
F33.8
ICD-10 Finland
Other recurrent depressive disorders
11.0
8.3
15
14
N06AX21
ATC
duloxetine; oral
3.1
8.2
43
146
MA3AE
NOMESCO Finland
Combined first trimester screening
0.1
8.2
*
279
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
10.3
8.1
15
15
N05AD01
ATC
haloperidol; systemic
11.1
7.8
14
13
N06AB05
ATC
paroxetine; oral
4.1
7.7
29
75
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.7
7.7
25
56
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
0.4
7.7
36
796
QB2S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in chest
25.5
7.6
10
*
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.4
7.6
29
697
N05AN01
ATC
lithium; oral
7.3
7.5
17
24
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
0.2
7.5
5
304
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.1
7.5
19
32
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
0.0
7.5
*
215
HAC99
NOMESCO Finland
Other mastectomy
81.4
7.4
8
*
SPAT1284
SPAT
Extensive health certificate
3.6
7.4
32
94
IDY25
NOMESCO Finland
Systematic individual therapy, visual arts psychotherapy
+∞
7.3
7
*
F33
ICD-10 Finland
Recurrent depressive disorder
4.8
7.3
23
50
Z37.0
ICD-10 Finland
Single live birth
0.2
7.3
5
302
N05BA01
ATC
diazepam; systemic, rectal
2.8
7.2
45
169
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.1
7.2
38
130
N03AX16
ATC
pregabalin; oral
2.5
7.2
56
243
W90
ICPC
Uncompl labour/delivery livebirth
0.1
7.2
*
230
SPAT1241
SPAT
Extensive assessment of psychosocial situation
4.9
7.1
22
47
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
0.1
7.1
*
252
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
0.1
7.1
*
276
N05AE04
ATC
ziprasidone; systemic
10.3
7.1
13
13
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
7.2
7.1
16
23
R4120
NOMESCO Finland
Occupational therapy
3.9
7.0
27
72
HA1AA
NOMESCO Finland
X-ray mammography
5.6
7.0
19
35
F50.0
ICD-10 Finland
Anorexia nervosa
5.2
6.9
20
40
N05AB03
ATC
perphenazine; systemic, rectal
5.5
6.8
19
36
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.3
6.8
32
101
P80
ICPC
Personality disorder
40.7
6.8
8
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
0.2
6.7
8
343
O80.8
ICD-10 Finland
Other single spontaneous delivery
0.0
6.6
*
192
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.5
6.5
29
88
P86
ICPC
Anorexia nervosa/bulimia
7.6
6.5
14
19
ZXY61
NOMESCO Finland
2-person team, special workers
14.6
6.4
10
7
N03AG01
ATC
valproic acid; systemic, rectal
3.4
6.4
29
89
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
8.3
6.4
13
16
HAC20
NOMESCO Finland
Total mastectomy
9.4
6.3
12
13
IER03
NOMESCO Finland
Psychiatric disorder-specific group intervention
18.3
6.3
9
5
RT250
NOMESCO Finland
NA
27.1
6.2
8
*
IGP01
NOMESCO Finland
Psychiatric family contact
5.5
6.2
17
32
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
4.5
6.1
20
46
IBA03
NOMESCO Finland
Psychotherapy evaluation
5.0
6.1
18
37
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
10.2
6.1
11
11
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
0.1
6.0
*
178
Mortality – FinRegistry
↥Association
Association between endpoint F5_GENDER and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have F5_GENDER.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: F5_GENDER – Gender identity disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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