infectious meningitis: Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
615 |
4. Check minimum number of eventsNone |
615 |
5. Include endpointsNone |
615 |
6. Filter based on genotype QC (FinnGen only) |
593 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other meningitis
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4841 | 2409 | 2393 |
| Only index persons | 4163 | 2151 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 40.27 | 41.58 | 38.59 |
| Only index persons | 37.69 | 39.51 | 35.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 593 | 371 | 222 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 44.22 | 42.52 | 47.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 615
- Matched controls
- 6145
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G03.9
ICD-10 Finland
Meningitis, unspecified
12622.7
307.7
445
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
90.5
187.5
99
13
TAB00
NOMESCO Finland
Lumbar puncture
14.5
152.0
153
137
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
+∞
90.9
85
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.7
78.5
145
269
AA1AD
NOMESCO Finland
CT of head and brain
4.3
66.9
266
929
R51.80
ICD-10 Finland
Headache
4.3
60.9
212
666
G03.8
ICD-10 Finland
Meningitis due to other specified causes
+∞
43.2
41
*
R50.9
ICD-10 Finland
Fever, unspecified
3.8
42.4
161
524
G03.0
ICD-10 Finland
Nonpyogenic meningitis
+∞
42.2
40
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.8
42.0
55
68
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
366.9
35.3
35
*
N03AX14
ATC
levetiracetam; systemic
8.1
31.8
44
58
G03.1
ICD-10 Finland
Chronic meningitis
+∞
29.4
28
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.7
27.8
101
313
A86
ICD-10 Finland
Unspecified viral encephalitis
60.7
25.2
29
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
23.4
304
1811
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
23.1
22
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
21.3
122
493
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
20.9
20
*
R51
ICD-10 Finland
Headache
3.9
19.3
60
166
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
18.8
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
18.2
161
797
WX882
NOMESCO Finland
High dependency care
5.8
17.9
33
59
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.0
17.1
50
132
H02AB06
ATC
prednisolone; systemic
2.1
16.9
308
2017
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
16.8
47
120
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
16.7
16
*
L04AX01
ATC
azathioprine; systemic
4.1
16.1
45
115
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.5
15.5
39
92
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
39.1
15.5
19
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
15.4
109
485
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.0
15.0
27
47
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
14.8
70
252
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.6
14.6
28
52
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
12.3
14.2
25
21
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
54.6
13.9
16
*
AAF00
NOMESCO Finland
Ventriculostomy
20.6
13.8
20
10
PA2AD
NOMESCO Finland
CT angiography of brain
20.6
13.8
20
10
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
6.7
13.7
22
34
N71
ICPC
Meningitis/encephalitis
+∞
13.6
13
*
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.7
13.4
25
45
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.4
13.1
49
153
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
13.4
13.0
22
17
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.5
12.8
45
135
WX872
NOMESCO Finland
Intensive care
3.7
12.7
41
116
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
12.5
107
516
N02AX02
ATC
tramadol; systemic, rectal
1.9
12.5
266
1783
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
12.2
73
298
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
6.2
12.2
21
35
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.4
12.1
31
74
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
12.1
30
70
G51.0
ICD-10 Finland
Bell palsy
4.8
12.0
27
58
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
12.0
109
539
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
11.9
127
668
H47.1
ICD-10 Finland
Papilloedema, unspecified
12.9
11.7
20
16
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
30.7
11.7
15
5
N03AX16
ATC
[U] pregabalin
2.0
11.6
150
848
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
11.5
91
423
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.1
11.4
32
82
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
5.7
11.2
21
38
J45.8
ICD-10 Finland
Mixed asthma
4.3
11.2
29
70
N03AX12
ATC
[U] gabapentin; oral
2.1
11.0
115
600
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
10.8
169
1018
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.7
10.7
20
36
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
10.6
103
521
ZXC95
NOMESCO Finland
Use of surgical navigator
8.7
10.6
22
26
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
111.8
10.4
11
*
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
10.4
10
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
10.4
10
*
H02AB07
ATC
prednisone; oral
2.2
10.4
91
442
R42
ICD-10 Finland
Dizziness and giddiness
2.0
10.3
138
786
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.8
10.3
31
84
B34.9
ICD-10 Finland
Viral infection, unspecified
3.8
10.3
31
84
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
10.2
143
828
G91.0
ICD-10 Finland
Communicating hydrocephalus
14.9
10.0
16
11
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
40.7
10.0
12
*
H02AB09
ATC
hydrocortisone; systemic
4.5
9.9
24
55
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
9.8
43
148
N03AF02
ATC
oxcarbazepine; oral
3.7
9.6
30
83
J05AB11
ATC
valaciclovir; oral
2.1
9.6
102
533
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.7
9.6
31
88
A87.8
ICD-10 Finland
Other viral meningitis
101.5
9.4
10
*
N06AA09
ATC
amitriptyline; systemic
2.5
9.4
63
271
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
9.4
9
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
22.1
9.4
13
6
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
9.2
84
414
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
9.1
265
1897
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
9.0
70
322
SPAT1255
SPAT
Intravenous administration of medicine
2.8
9.0
46
173
ZXD05
NOMESCO Finland
Urgent procedure
1.7
8.8
193
1275
A02BC02
ATC
pantoprazole; systemic
1.7
8.8
390
3107
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.3
8.8
20
28
G91.1
ICD-10 Finland
Obstructive hydrocephalus
14.3
8.7
14
10
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
50.7
8.7
10
*
ZX120
NOMESCO Finland
Intravenous
2.4
8.6
63
282
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.2
8.6
17
19
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
9.2
8.6
17
19
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
8.6
69
323
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
8.3
41
151
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
8.2
136
827
WX704
NOMESCO Finland
Intubation
2.4
8.2
56
244
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
8.1
76
378
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
8.1
74
365
G44.2
ICD-10 Finland
Tension-type headache
2.0
8.0
99
545
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.3
7.9
29
90
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.3
7.8
20
48
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.8
230
1637
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
7.7
51
218
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.4
7.7
28
86
5AB01, ,
NOMESCO Finland
45.5
7.7
9
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.6
7.7
44
176
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.6
152
973
H53.2
ICD-10 Finland
Diplopia
3.5
7.6
26
77
J01DB01
ATC
cefalexin; oral
1.8
7.5
500
4344
H53.4
ICD-10 Finland
Visual field defects
4.5
7.5
18
41
G44.8
ICD-10 Finland
Other specified headache syndromes
6.1
7.4
19
32
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
11.0
7.3
13
12
N03AX18
ATC
lacosamide; systemic
11.0
7.3
13
12
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.0
7.3
13
12
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
7.3
7
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.3
7.2
57
265
ABE50
NOMESCO Finland
Occipitocervical decompression
30.4
7.2
9
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
7.2
40
158
WX730
NOMESCO Finland
Conventional respirator
8.1
7.1
15
19
R41.0
ICD-10 Finland
Disorientation, unspecified
3.8
7.0
21
57
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
6.9
33
120
J01MA14
ATC
moxifloxacin; systemic
2.3
6.7
54
252
S06.0
ICD-10 Finland
Concussion
2.0
6.7
75
398
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.7
171
1165
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
22.8
6.7
9
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
6.6
54
254
M01AE02
ATC
naproxen; oral, rectal
1.6
6.6
348
2802
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
2.8
6.6
33
123
WX725
NOMESCO Finland
Noninvasive ventilation
2.6
6.6
38
153
M05BA04
ATC
alendronic acid; oral
2.4
6.5
46
203
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
5.8
6.5
17
30
R25.2
ICD-10 Finland
Cramp and spasm
3.6
6.5
21
60
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
6.5
153
1021
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.9
6.4
30
108
N01
ICPC
Headache
1.9
6.4
87
495
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
6.3
27
92
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.4
6.3
22
66
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
6.3
213
1551
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.8
6.3
31
115
G09
ICD-10 Finland
Sequelae of inflammatory diseases of central nervous system
+∞
6.3
6
*
B00.4
ICD-10 Finland
Herpesviral encephalitis
+∞
6.3
6
*
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
6.3
6
*
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
6.3
6
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
6.3
6
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
7.1
6.2
14
20
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
26.9
6.2
8
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.7
6.2
19
52
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.2
179
1256
N03AE01
ATC
clonazepam; systemic
2.5
6.1
37
152
WX402
NOMESCO Finland
General anaesthesia
1.7
6.1
124
793
XLA10, ,
NOMESCO Finland
2.8
6.1
29
105
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.0
117
739
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.3
6.0
17
33
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
6.0
57
285
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
159
39
54.59
271.27
2.3
1.2
—
—
—
0
0
193
123
22.39
235.35
2.2
1.2
913.84
437.40
mg/l
8.15
187
114
185
110
23.60
232.96
2.0
1.1
3.32
3.80
mmol/l
3.38
177
101
159
113
18.61
181.50
2.1
1.2
1327.04
1088.65
e6/l
0.08
130
92
159
113
18.61
181.50
2.0
1.2
373.12
4.93
e6/l
2.66
130
87
94
21
52.61
161.69
1.4
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
94
25
44.17
155.04
1.4
1.1
—
—
—
0
0
84
16
60.60
149.05
2.2
1.1
—
—
—
0
0
66
20
36.82
104.31
1.3
1.1
—
—
—
0
0
78
47
18.85
95.00
1.1
1.0
—
—
—
0
0
47
15
33.82
72.72
1.3
1.1
—
—
—
0
0
49
18
29.47
72.53
1.3
1.3
—
—
—
0
0
46
14
35.40
72.15
1.3
1.1
—
—
—
0
0
44
15
31.49
66.62
1.2
1.1
—
—
—
0
0
137
317
5.27
57.49
1.6
1.3
42.22
35.71
au/ml
—
9
21
140
357
4.78
51.98
2.8
2.4
37.38
22.46
au/ml
—
9
21
39
22
18.84
48.43
1.1
1.0
—
—
—
0
0
43
42
10.92
39.04
1.7
1.6
—
—
—
0
0
37
32
12.23
36.32
1.3
1.2
—
—
—
0
0
40
8
53.26
33.88
1.2
1.1
—
—
—
0
0
39
14
29.61
29.24
1.4
1.1
—
—
—
0
0
167
709
2.86
27.09
2.0
1.8
—
—
—
0
0
32
36
9.31
26.13
1.8
1.7
—
—
—
0
0
35
14
26.38
25.53
1.4
1.1
—
—
—
0
0
34
43
8.30
25.34
1.3
1.1
62.67
30.08
mg/l
2.29
27
33
30
33
9.50
24.89
1.3
1.1
1.30
1.09
u/l
0.77
18
18
31
9
36.14
24.48
1.3
1.3
—
—
—
0
0
28
5
58.48
24.21
1.4
1.2
—
—
—
0
0
54
123
4.71
22.40
2.1
1.5
—
—
—
0
0
30
38
8.24
22.30
1.1
1.0
—
—
—
0
0
246
1363
2.34
22.14
2.9
2.1
145.68
295.34
u/l
1.35
241
1293
345
2234
2.24
20.96
8.9
6.5
1.21
1.22
mmol/l
1.46
300
1896
55
137
4.31
20.38
1.4
1.1
—
—
—
0
0
322
2050
2.20
20.13
11.6
11.3
1.21
1.19
inr
0.22
88
656
29
41
7.37
19.63
1.1
1.1
344.68
214.75
mg/l
1.60
22
36
39
75
5.48
19.61
1.2
1.1
—
—
—
0
0
396
2766
2.21
19.21
6.2
4.7
6.50
6.57
mmol/l
0.36
381
2559
39
79
5.20
18.51
1.5
1.5
—
—
—
0
0
363
2483
2.12
18.15
7.2
5.9
10.68
10.75
umol/l
0.03
350
2352
23
7
34.02
18.07
1.1
1.0
—
—
—
0
0
312
2032
2.08
17.60
8.6
5.8
1.21
1.22
mmol/l
1.21
295
1867
112
480
2.63
17.19
2.1
1.8
—
—
—
0
0
54
156
3.70
16.29
2.2
1.8
1.16
3.14
ug/l
0.54
49
139
109
486
2.51
15.32
2.0
1.8
—
—
—
0
0
345
2417
1.97
14.98
8.8
5.9
28.10
28.58
%
0.32
329
2281
392
2871
2.00
14.94
11.0
8.9
4.30
3.99
e9/l
1.51
353
2512
291
1927
1.97
14.87
5.7
4.6
35.50
36.14
g/l
1.02
278
1804
102
448
2.53
14.77
9.8
8.8
1.04
1.21
mmol/l
0.17
80
359
46
131
3.71
14.16
1.5
1.3
—
—
—
0
0
22
34
6.67
13.71
2.0
2.0
—
—
—
0
0
32
71
4.70
13.67
1.3
1.1
—
—
—
0
0
337
2391
1.90
13.57
8.4
5.7
57.03
56.85
%
0.10
320
2255
19
9
21.71
13.39
1.1
1.0
—
—
—
0
0
19
9
21.71
13.39
1.1
1.0
—
—
—
0
0
17
6
29.05
13.01
1.4
1.0
—
—
—
0
0
232
1492
1.89
12.36
2.7
2.4
48.48
59.69
u/l
2.75
221
1388
257
1712
1.86
12.23
3.5
3.4
21.26
56.96
ng/l
0.94
160
1088
412
3197
1.87
11.75
6.8
4.2
7700.63
1439.37
e6/l
—
8
52
461
3713
1.96
11.68
10.3
7.2
76.25
77.45
u/l
0.29
452
3485
50
170
3.11
11.68
2.4
1.7
—
—
—
0
0
35
95
3.84
11.54
5.3
5.9
763.80
443.71
iu/ml
—
5
14
62
240
2.76
11.49
1.7
1.7
—
—
—
0
0
57
212
2.86
11.37
1.8
2.2
37.45
40.88
u/l
0.72
51
193
75
322
2.51
11.30
1.8
1.6
—
—
—
0
0
131
721
2.04
10.84
4.5
3.6
0.83
0.82
mmol/l
0.48
126
684
13
5
26.48
9.84
1.2
1.2
—
—
—
0
0
22
30
7.56
9.77
1.4
1.2
—
—
—
0
0
49
183
2.82
9.71
1.9
1.8
—
—
—
0
0
29
78
3.85
9.69
1.2
1.5
—
—
—
0
0
29
78
3.85
9.69
1.2
1.5
—
—
—
0
0
44
157
2.94
9.47
3.5
2.2
—
—
—
0
0
36
114
3.29
9.46
1.6
1.6
—
—
—
0
0
91
459
2.15
9.41
3.5
4.2
230.76
262.66
u/l
0.93
86
439
239
1668
1.71
9.00
4.5
3.1
—
—
—
0
0
36
118
3.18
8.95
1.6
1.6
—
—
—
0
0
37
126
3.06
8.64
3.2
2.6
—
—
—
0
0
172
1116
1.75
8.31
1.9
1.7
1.40
1.12
mg/l
0.51
130
835
60
269
2.36
8.21
1.5
1.4
—
—
—
0
0
136
828
1.82
8.13
3.6
3.6
120.06
328.65
ng/l
1.14
90
598
78
398
2.10
7.80
3.8
3.7
1.59
1.83
mmol/l
0.23
69
321
316
2449
1.59
7.42
7.1
4.7
0.00
0.00
estimate
-0.00
63
486
15
18
8.50
7.35
2.4
1.9
—
—
—
0
0
35
127
2.86
7.33
1.3
1.2
—
—
—
0
0
27
85
3.27
7.19
1.6
1.6
—
—
—
0
0
11
8
13.96
6.91
1.3
1.3
—
—
—
0
0
28
93
3.10
6.84
1.2
1.1
—
10.83
—
0
7
12
11
11.09
6.81
2.2
1.7
—
—
—
0
0
316
2483
1.56
6.76
5.3
3.4
0.00
0.01
estimate
0.50
62
465
296
2294
1.56
6.72
3.0
2.5
—
—
—
0
0
431
3655
1.60
6.43
5.7
3.9
12.70
10.66
mm/h
2.54
417
3379
310
2448
1.53
6.34
5.3
3.4
0.00
0.00
estimate
0.50
64
501
28
98
2.94
6.28
4.1
3.7
3.63
4.31
e9/l
0.61
28
98
182
1280
1.60
6.20
4.6
2.9
0.31
0.43
e6/l
0.38
145
968
149
999
1.65
6.16
4.2
2.5
7.29
6.02
e6/l
0.29
139
892
28
100
2.88
6.06
2.1
4.2
32.29
36.67
umol/l
0.57
28
90
28
100
2.88
6.06
5.0
4.2
52.43
57.91
%
1.05
28
100
20
58
3.53
6.05
1.2
1.4
—
—
—
0
0
20
58
3.53
6.05
1.2
1.4
—
—
—
0
0
118
748
1.71
6.02
3.2
2.6
1.65
0.98
e6/l
0.52
64
413
172
1201
1.60
6.01
5.3
3.6
91.11
92.95
%
0.45
167
1174
261
2006
1.52
5.93
3.0
2.3
75.20
75.38
nmol/l
0.04
248
1811
197
1425
1.56
5.90
4.8
3.1
28.10
96.35
e6/l
0.85
162
1104
36
150
2.48
5.81
1.7
1.5
0.01
0.04
iu/ml
—
5
24
11
12
9.30
5.80
1.2
1.0
8.05
5.53
mg/g
0.41
11
12
26
92
2.90
5.73
1.3
1.4
—
—
—
0
0
26
92
2.90
5.73
1.3
1.4
—
—
—
0
0
14
23
6.20
5.71
1.2
1.1
1370.57
1767.26
miu/ml
0.53
14
23
222
1661
1.52
5.66
3.6
3.2
32.65
31.51
u/l
0.26
215
1581
163
1148
1.57
5.42
2.9
2.1
—
—
—
0
0
16
34
4.80
5.33
1.3
1.1
—
—
—
0
0
9
8
11.38
5.30
1.4
1.1
—
—
—
0
0
232
1776
1.49
5.21
2.1
1.9
102.75
95.29
pmol/l
1.15
126
930
135
924
1.59
5.05
1.6
1.7
113386267.04
40540975.57
pmol/l
0.28
127
777
21
72
2.98
4.91
1.6
1.6
—
—
—
0
0
108
708
1.64
4.80
3.4
2.8
2.58
2.63
e6/l
0.03
56
378
405
3487
1.47
4.80
4.2
3.1
53.84
41.93
u/l
1.40
396
3293
246
1938
1.45
4.64
5.5
3.5
—
—
—
0
0
547
5044
1.76
4.64
22.8
12.5
23.18
21.47
mg/l
0.58
496
3909
53
285
1.94
4.61
6.5
3.7
0.90
1.55
mmol/l
0.70
41
204
201
1529
1.47
4.53
3.5
3.1
2.35
2.35
mmol/l
0.43
182
1375
30
131
2.35
4.42
1.6
1.3
13.72
2.63
u/ml
—
6
18
30
132
2.34
4.35
1.6
1.3
8.62
12.44
u/ml
—
9
26
59
337
1.83
4.29
2.3
2.3
4.60
6.65
ug/l
0.84
50
301
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
115
2.41
4.21
4.1
2.4
0.41
0.37
u/ml
0.20
15
64
18
62
2.96
4.19
1.7
1.7
—
—
—
0
0
23
91
2.58
4.17
1.8
1.4
—
—
—
0
0
22
86
2.61
4.09
1.1
1.1
—
—
—
0
0
543
5033
1.67
4.05
23.7
13.8
139.32
139.68
mmol/l
2.43
538
4897
7
7
10.09
4.01
1.0
1.1
—
—
—
0
0
14
36
3.95
4.01
1.6
1.6
—
—
—
0
0
175
1323
1.45
4.00
6.0
3.7
0.00
0.01
estimate
0.69
59
475
14
37
3.84
3.91
1.1
1.7
—
—
—
0
0
14
37
3.84
3.91
1.1
1.7
—
—
—
0
0
14
37
3.84
3.91
1.1
1.7
—
—
—
0
0
543
5049
1.64
3.80
23.5
13.9
3.95
3.96
mmol/l
0.38
538
4899
158
1189
1.44
3.67
2.7
2.5
336.71
6668.93
umol/l
4.59
150
1042
112
788
1.51
3.65
1.8
1.7
1307.04
1169.24
nmol/l
0.79
94
591
10
21
4.82
3.56
1.1
1.8
—
—
—
0
0
10
21
4.82
3.56
1.1
1.8
—
—
—
0
0
13
36
3.66
3.51
1.4
1.2
—
—
—
0
0
21
87
2.46
3.50
1.1
1.1
—
—
—
0
0
20
81
2.52
3.49
2.1
1.7
—
—
—
0
0
148
1110
1.44
3.48
1.7
1.4
2.19
2.32
g/l
0.47
112
707
38
202
1.94
3.46
2.5
2.5
0.68
0.64
%
0.38
38
202
8
14
5.77
3.34
1.1
2.0
—
—
—
0
0
8
14
5.77
3.34
1.1
2.0
—
—
—
0
0
52
310
1.74
3.31
2.4
3.1
169.61
173.86
ng/l
0.03
46
275
153
1166
1.41
3.28
2.9
3.1
814.90
1029.88
ng/l
0.72
126
973
12
34
3.58
3.21
1.5
1.2
1.10
1.07
ratio
—
7
16
8
15
5.38
3.19
1.1
1.9
—
—
—
0
0
145
1101
1.41
3.17
5.0
3.5
1.01
1.02
kg/l
1.17
25
156
91
639
1.50
2.99
2.8
2.3
2.33
2.36
g/l
0.19
85
584
109
794
1.45
2.98
3.0
2.6
2.44
2.44
mmol/l
0.03
95
704
136
1032
1.41
2.97
1.7
1.5
22.73
20.79
nmol/l
0.74
117
875
23
109
2.15
2.87
1.6
1.4
—
—
—
0
0
78
537
1.52
2.82
6.4
6.2
—
—
—
0
0
15
59
2.58
2.80
1.5
1.3
—
—
—
0
0
22
104
2.15
2.77
2.1
2.0
126.62
132.48
g/l
0.33
13
79
20
91
2.24
2.76
1.5
1.2
13.25
4.03
u/ml
—
8
39
20
91
2.24
2.76
1.4
1.2
2.50
4.13
u/ml
—
8
31
504
4690
1.41
2.72
16.5
11.4
86.79
85.85
ml/min/173m2
0.41
443
3847
30
162
1.89
2.66
2.1
2.5
—
—
—
0
0
20
94
2.16
2.57
1.8
1.8
3.53
4.68
mmol/24h
0.71
20
80
80
565
1.48
2.56
2.9
2.9
8.41
7.98
umol/l
0.06
67
486
12
44
2.76
2.55
1.5
1.3
—
—
—
0
0
14
56
2.53
2.54
1.2
1.1
—
—
—
0
0
8
21
3.84
2.47
1.3
1.3
—
—
—
0
0
8
21
3.84
2.47
1.3
1.3
—
—
—
0
0
14
57
2.49
2.46
1.2
1.2
—
—
—
0
0
12
45
2.70
2.46
1.5
1.3
—
—
—
0
0
560
5337
1.54
2.45
14.4
9.6
28.12
26.32
u/l
1.65
552
5177
14
58
2.44
2.38
1.5
1.3
—
—
—
0
0
14
58
2.44
2.38
1.5
1.3
—
—
—
0
0
50
324
1.59
2.38
3.0
3.7
4.43
4.62
pmol/l
0.57
45
288
422
3855
1.30
2.35
4.7
4.0
14.81
14.63
pmol/l
0.72
394
3515
14
59
2.40
2.30
1.5
1.3
—
—
—
0
0
14
59
2.40
2.30
1.5
1.3
—
—
—
0
0
14
59
2.40
2.30
1.5
1.3
—
—
—
0
0
82
595
1.44
2.30
3.0
2.3
22.10
23.32
%
0.27
66
511
65
451
1.49
2.29
2.1
2.2
28.32
31.56
u/l
0.57
56
382
6
13
4.65
2.27
1.2
1.2
—
—
—
0
0
31
183
1.73
2.11
1.5
1.3
—
—
—
0
0
399
3647
1.27
2.06
3.5
3.3
—
—
—
0
0
7
20
3.52
2.06
1.3
1.3
—
—
—
0
0
7
20
3.52
2.06
1.3
1.3
—
—
—
0
0
64
455
1.45
2.01
3.4
3.2
—
—
—
0
0
10
38
2.66
2.01
1.6
1.2
—
—
—
0
0
9
32
2.84
2.00
1.7
2.4
—
—
—
0
0
20
105
1.93
1.97
1.8
1.4
222.38
232.71
u/ml
0.09
13
64
42
275
1.56
1.95
1.6
1.3
29.39
25.26
iu/l
0.28
36
232
5
11
4.57
1.94
1.0
1.0
—
—
—
0
0
18
92
1.98
1.91
2.9
2.1
15.58
16.77
%
—
9
47
473
4432
1.29
1.89
5.5
5.3
39.34
39.31
mmol/mol
0.02
449
4149
7
22
3.20
1.88
1.1
1.4
—
—
—
0
0
25
144
1.77
1.87
3.3
2.4
3.70
3.54
g/l
0.24
25
139
73
541
1.40
1.84
4.2
4.2
33.24
31.65
%
0.52
54
365
140
1150
1.28
1.77
2.4
2.1
3.04
2.96
mg/l
0.13
125
985
6
18
3.35
1.75
2.3
1.7
122.95
57.98
ug/l
—
6
18
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
105
837
1.31
1.66
1.2
1.3
10.63
12.33
u/ml
0.13
39
335
108
871
1.29
1.57
1.3
1.3
41.99
31.26
iu/ml
0.30
36
280
14
72
1.96
1.49
2.1
1.5
—
—
—
0
0
19
109
1.77
1.48
1.5
1.3
—
—
—
0
0
137
1150
1.24
1.44
1.8
1.6
—
—
—
0
0
6
22
2.74
1.43
1.2
1.4
—
—
—
0
0
9
39
2.32
1.43
2.4
2.4
—
—
—
0
0
16
89
1.82
1.38
1.6
1.5
0.27
0.35
nmol/l
0.36
11
74
9
41
2.21
1.37
2.6
1.7
—
—
—
0
0
29
191
1.54
1.37
2.1
1.7
—
—
—
0
0
26
167
1.58
1.36
1.2
1.2
—
—
—
0
0
252
2260
1.19
1.35
3.4
2.8
114.24
98.91
ug/l
0.59
239
2098
26
168
1.57
1.33
1.2
1.2
—
—
—
0
0
165
1431
1.21
1.26
3.3
3.0
7.66
7.76
mmol/l
0.10
146
1213
26
173
1.52
1.19
1.9
1.6
—
—
—
0
0
11
57
1.95
1.17
2.5
2.2
—
—
—
0
0
48
361
1.36
1.17
2.2
1.9
—
—
—
0
0
17
103
1.67
1.13
1.4
1.7
—
—
—
0
0
7
30
2.35
1.12
1.1
1.1
—
—
—
0
0
21
136
1.56
1.09
1.2
1.4
225.50
312.56
ug/g
1.35
11
82
20
128
1.58
1.09
1.6
2.8
0.01
0.04
g/l
0.33
20
119
92
767
1.23
1.05
1.9
2.1
—
—
—
0
0
5
22
2.28
1.03
3.6
2.9
45440.00
35250.23
ug/l
—
5
22
5
22
2.28
1.03
3.0
1.9
31.00
29.95
umol/l
—
5
22
11
60
1.85
1.03
2.4
1.6
—
—
—
0
0
7
34
2.07
1.03
1.9
1.4
1.57
9.51
u/l
—
7
27
11
61
1.82
0.98
1.0
1.1
1.37
1.45
g/l
0.29
11
53
11
61
1.82
0.98
1.9
1.6
—
—
—
0
0
83
691
1.23
0.96
1.6
1.8
1.50
1.41
%
0.48
72
614
7
37
1.90
0.94
4.7
3.0
—
—
—
0
0
44
340
1.32
0.93
5.5
3.7
87.33
77.24
ng/l
0.42
39
303
478
4602
1.17
0.88
5.5
4.7
1.86
2.12
mu/l
0.46
450
4246
18
120
1.51
0.86
1.6
1.2
—
—
—
0
0
12
72
1.68
0.85
1.3
1.3
—
—
—
0
0
149
1330
1.16
0.81
3.8
3.8
17.85
9.63
mg/mmol
0.61
95
843
41
516
0.78
0.80
1.9
1.6
—
—
—
0
0
7
122
0.57
0.78
2.0
1.6
—
—
—
0
0
0
26
0.00
0.78
0.0
1.2
—
169.32
—
0
26
6
34
1.77
0.76
1.5
1.3
—
—
—
0
0
10
59
1.71
0.76
1.3
1.3
—
—
—
0
0
47
382
1.25
0.71
2.7
2.5
70.05
69.62
ml/min/173m2
0.02
20
168
106
934
1.16
0.69
1.5
1.4
—
—
—
0
0
97
849
1.17
0.69
2.1
2.2
—
—
—
0
0
5
27
1.86
0.68
1.2
1.9
—
—
—
0
0
5
27
1.86
0.68
2.4
1.7
—
—
—
0
0
5
27
1.86
0.68
1.2
1.9
—
—
—
0
0
5
28
1.79
0.66
2.4
1.7
—
—
—
0
0
5
30
1.67
0.61
2.4
1.7
—
—
—
0
0
54
457
1.20
0.58
2.5
1.9
—
—
—
0
0
16
115
1.40
0.57
1.6
1.3
—
—
—
0
0
25
196
1.29
0.53
1.5
1.4
—
—
—
0
0
19
144
1.33
0.51
1.3
1.9
2.34
6.05
iu/l
—
5
51
7
45
1.56
0.49
1.3
1.2
—
—
—
0
0
7
45
1.56
0.49
1.3
1.2
—
—
—
0
0
15
110
1.37
0.49
2.7
1.9
196.47
226.82
pmol/l
0.48
15
102
7
46
1.53
0.48
1.3
1.2
—
—
—
0
0
7
46
1.53
0.48
1.3
1.0
—
—
—
0
0
7
46
1.53
0.48
1.3
1.2
—
—
—
0
0
7
46
1.53
0.48
1.3
1.2
—
—
—
0
0
26
318
0.81
0.45
1.1
1.0
—
—
—
0
0
16
121
1.33
0.44
1.7
2.8
0.00
0.00
g/l
-0.00
16
112
26
211
1.24
0.44
1.3
1.3
227.87
232.96
miu/ml
0.03
11
105
62
699
0.87
0.43
2.9
2.8
0.72
0.73
ug/l
0.07
43
426
5
31
1.62
0.43
4.0
3.1
—
—
—
0
0
41
351
1.18
0.42
2.7
2.2
10.02
13.34
nmol/l
1.86
33
322
5
33
1.52
0.41
1.0
1.5
68.60
72.06
umol/l
—
5
33
5
35
1.43
0.39
1.2
1.6
—
—
—
0
0
5
35
1.43
0.39
2.4
1.8
—
—
—
0
0
10
71
1.41
0.39
1.4
1.8
13.20
13.16
%
—
10
71
5
36
1.39
0.38
6.6
2.6
67.00
102.39
%
—
5
36
5
37
1.35
0.37
1.4
1.4
—
—
—
0
0
481
4715
1.09
0.36
3.8
3.7
1.37
1.27
mmol/l
2.16
463
4386
23
189
1.22
0.36
1.3
1.4
—
—
—
0
0
23
189
1.22
0.36
1.3
1.4
—
—
—
0
0
500
4911
1.09
0.35
4.2
4.1
4.74
4.70
mmol/l
0.38
478
4595
23
190
1.22
0.35
1.3
1.4
—
—
—
0
0
23
190
1.22
0.35
1.3
1.4
—
—
—
0
0
103
955
1.09
0.33
4.0
4.0
19.06
21.50
%
1.07
52
419
12
153
0.78
0.31
1.7
1.8
—
—
—
0
0
506
4981
1.08
0.31
4.7
4.5
2.79
2.81
mmol/l
0.11
481
4631
31
268
1.16
0.30
2.3
2.3
918.34
2447.70
u/l
0.85
13
116
38
334
1.15
0.30
1.1
1.3
—
—
—
0
0
15
120
1.26
0.30
1.8
2.9
0.00
0.00
g/l
-0.00
15
112
7
56
1.25
0.29
4.0
2.5
105.57
105.70
mmol/l
—
7
56
18
216
0.83
0.28
2.1
1.8
—
—
—
0
0
13
103
1.27
0.28
6.4
3.7
20.60
27.02
mg/l
—
5
65
121
1279
0.93
0.27
1.7
1.6
1.54
1.38
mmol/l
0.90
106
1080
8
67
1.20
0.26
1.4
1.2
0.55
0.51
nmol/l
—
8
60
6
83
0.72
0.24
1.2
1.2
94.92
33.99
u/l
—
6
72
31
347
0.89
0.23
1.5
1.5
—
—
—
0
0
479
4724
1.06
0.22
4.4
4.2
5.86
5.86
mmol/l
0.00
454
4349
26
229
1.14
0.22
1.3
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
495
4889
1.06
0.21
4.2
4.1
1.48
1.47
mmol/l
0.05
472
4552
45
413
1.10
0.20
1.3
1.2
136.71
157.60
iu/ml
0.11
18
168
571
5668
1.09
0.19
30.8
18.3
258.89
253.28
e9/l
1.14
566
5550
6
52
1.15
0.19
2.0
1.5
53.67
52.29
%
—
6
38
46
424
1.09
0.19
3.7
4.0
4.34
16.92
ug/l
0.65
35
342
571
5669
1.09
0.18
31.0
18.3
39.94
40.48
%
1.55
547
5361
12
100
1.20
0.18
1.0
1.1
0.47
2.10
u/ml
—
7
56
571
5672
1.08
0.16
30.7
18.3
4.47
4.53
e12/l
2.48
564
5536
26
287
0.90
0.16
1.8
2.5
31.23
54.30
u/ml
0.66
26
274
13
111
1.17
0.15
1.0
1.1
1.13
4.18
u/ml
—
7
60
129
1244
1.05
0.15
1.3
1.3
1.45
1.66
u/ml
0.12
35
342
14
160
0.87
0.14
1.6
1.6
—
—
—
0
0
121
1184
1.03
0.07
4.9
4.5
4.16
2.27
ug/l
0.44
116
1066
22
206
1.07
0.07
1.4
1.5
—
—
—
0
0
8
94
0.85
0.06
1.0
1.2
—
—
—
0
0
19
177
1.07
0.06
2.0
1.5
—
—
—
0
0
12
112
1.07
0.02
1.6
2.3
96.08
142.02
ug/min
—
5
67
10
93
1.08
0.02
1.5
1.8
—
—
—
0
0
10
103
0.97
0.00
1.8
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
0.43
—
0
7
5
54
0.92
0.00
1.0
1.3
—
—
—
0
0
5
55
0.91
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
5.36
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
11.28
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
59.20
—
0
6
0
5
0.00
-0.00
0.0
5.6
—
17.60
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGOTH | 2.298 [1.88, 2.8] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1695 females with G6_MENINGOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGOTH | 2.392 [1.93, 2.96] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1631 males with G6_MENINGOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_MENINGOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.399% |
| 5 | 1.228% | 2.535% |
| 10 | 3.051% | 6.679% |
| 15 | 5.931% | 12.873% |
| 20 | 10.511% | 21.46% |
Relationships between endpoints
↥Index endpoint: G6_MENINGOTH – Other meningitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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