infectious meningitis: Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
581 |
4. Check minimum number of eventsNone |
581 |
5. Include endpointsNone |
581 |
6. Filter based on genotype QC (FinnGen only) |
581 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other meningitis
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4841 | 2409 | 2393 |
| Only index persons | 4163 | 2151 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 40.27 | 41.58 | 38.59 |
| Only index persons | 37.69 | 39.51 | 35.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 581 | 367 | 214 |
| Unadjusted period prevalence (%) | 0.11 | 0.13 | 0.09 |
| Median age at first event (years) | 43.35 | 42.06 | 45.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 516
- Matched controls
- 5158
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G03.9
ICD-10 Finland
Meningitis, unspecified
+∞
323.0
361
*
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
+∞
84.8
79
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
99.0
83.2
90
11
TAB00
NOMESCO Finland
Lumbar puncture
16.8
74.7
124
95
R51.80
ICD-10 Finland
Headache
4.9
42.5
163
444
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.2
41.9
110
188
G03.0
ICD-10 Finland
Nonpyogenic meningitis
+∞
40.1
38
*
AA1AD
NOMESCO Finland
CT of head and brain
4.1
38.0
179
587
G03.8
ICD-10 Finland
Meningitis due to other specified causes
+∞
36.9
35
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
+∞
32.6
31
*
G03.1
ICD-10 Finland
Chronic meningitis
+∞
29.5
28
*
A86
ICD-10 Finland
Unspecified viral encephalitis
109.3
19.7
21
*
R50.9
ICD-10 Finland
Fever, unspecified
3.2
19.7
116
426
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
18.9
18
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
18.9
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
17.1
225
1302
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
16.8
16
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
49.2
16.1
19
*
AAF00
NOMESCO Finland
Ventriculostomy
87.8
15.7
17
*
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
164.8
15.6
16
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
17.1
14.9
23
14
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.4
14.8
35
50
H02AB06
ATC
prednisolone; systemic
2.0
13.6
250
1624
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
13.6
86
328
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.4
13.4
67
216
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
13.1
123
588
N03AX14
ATC
levetiracetam; systemic
7.9
12.6
28
37
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
16.9
11.7
18
11
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
66.5
11.7
13
*
R51
ICD-10 Finland
Headache
4.0
11.6
47
127
L04AX01
ATC
azathioprine; systemic
4.7
11.5
39
89
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
122.6
11.5
12
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
11.1
212
1363
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
11.1
97
443
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.2
11.0
41
103
H47.1
ICD-10 Finland
Papilloedema, unspecified
28.7
10.8
14
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
10.7
77
317
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
61.3
10.7
12
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.6
10.7
36
82
N71
ICPC
Meningitis/encephalitis
112.2
10.5
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
10.4
149
850
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
33.3
10.4
13
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.9
10.3
20
21
G91.0
ICD-10 Finland
Communicating hydrocephalus
23.9
10.3
14
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
10.1
67
263
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
15.0
10.1
16
11
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
9.8
56
199
H02AB07
ATC
prednisone; oral
2.5
9.6
81
362
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
9.6
88
411
XA800
NOMESCO Finland
Neuropsychological investigation
4.4
9.6
34
82
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
9.5
85
392
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
101.8
9.4
10
*
G00.1
ICD-10 Finland
Pneumococcal meningitis
+∞
9.4
9
*
A87.8
ICD-10 Finland
Other viral meningitis
+∞
9.4
9
*
N03AX16
ATC
pregabalin; oral
2.1
9.4
123
676
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
8.9
9.4
19
22
R42
ICD-10 Finland
Dizziness and giddiness
2.1
9.3
111
585
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
8.0
9.2
20
26
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
9.2
189
1227
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
15.9
9.1
14
9
G51.0
ICD-10 Finland
Bell palsy
5.8
8.9
24
43
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
7.1
8.6
20
29
ZXC95
NOMESCO Finland
Use of surgical navigator
9.2
8.6
17
19
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
28.0
8.5
11
*
5AB01
NOMESCO Finland
NA
91.5
8.4
9
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.6
8.4
28
64
N06AA09
ATC
amitriptyline; systemic
2.7
8.4
56
220
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
8.4
8
*
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
8.4
8
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
8.4
8
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
33.9
8.1
10
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
9.1
8.1
16
18
WX882
NOMESCO Finland
High dependency care
4.7
8.0
26
58
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
8.0
83
412
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
7.9
54
216
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.0
7.9
24
50
SPAT1255
SPAT
Intravenous administration of medicine
3.2
7.8
39
127
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.8
75
360
P01BA02
ATC
hydroxychloroquine; oral
2.9
7.7
48
179
TKC20
NOMESCO Finland
Catheterisation of bladder
3.2
7.7
39
129
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
81.2
7.4
8
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
81.2
7.4
8
*
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
81.2
7.4
8
*
ABE50
NOMESCO Finland
Occipitocervical decompression
+∞
7.3
7
*
J01EA01
ATC
trimethoprim; systemic
1.9
7.2
130
794
N03AX12
ATC
gabapentin; oral
2.1
7.2
81
413
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.3
7.2
34
107
G44.2
ICD-10 Finland
Tension-type headache
2.2
7.1
77
388
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
7.1
65
302
G43.9
ICD-10 Finland
Migraine, unspecified
2.9
7.1
41
148
J05AB11
ATC
valaciclovir; oral
2.1
7.0
78
396
N01
ICPC
Headache
2.3
7.0
67
320
H53.2
ICD-10 Finland
Diplopia
4.8
6.8
21
45
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
40.6
6.8
8
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
7.3
6.7
15
21
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.3
6.7
15
21
AA1AA
NOMESCO Finland
Head X-ray examination
22.9
6.7
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
6.7
93
518
M01AE02
ATC
naproxen; oral, rectal
1.6
6.6
285
2235
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
6.6
53
232
H02AB09
ATC
hydrocortisone; systemic
4.6
6.5
21
47
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.0
6.5
37
131
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
6.4
48
203
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
8.3
6.4
13
16
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.2
6.3
11
10
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.9
6.3
19
40
B34.9
ICD-10 Finland
Viral infection, unspecified
3.9
6.3
24
64
G00.2
ICD-10 Finland
Streptococcal meningitis
+∞
6.3
6
*
G44.8
ICD-10 Finland
Other specified headache syndromes
7.2
6.3
14
20
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
6.2
144
949
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.1
6.2
18
36
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
6.2
57
264
N02BE01
ATC
paracetamol; systemic, rectal
1.7
6.2
417
3647
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
6.1
158
1075
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
6.1
181
1278
ZX120
NOMESCO Finland
Intravenous
2.4
6.0
49
217
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
144
37
51.37
242.54
2.3
1.2
—
—
—
0
0
173
118
20.44
203.16
2.2
1.2
908.4
441.4
mg/l
6.78
167
110
166
105
21.71
202.29
2.0
1.1
3.3
3.8
mmol/l
3.28
158
97
142
109
16.90
154.85
2.1
1.2
1431.7
1124.8
e6/l
0.11
119
89
142
109
16.90
154.85
2.0
1.2
376.3
5.1
e6/l
2.34
118
84
86
20
50.25
146.45
1.4
1.1
—
—
—
0
0
79
15
60.75
140.21
2.3
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
83
25
38.53
132.10
1.4
1.1
—
—
—
0
0
56
19
32.48
85.33
1.3
1.1
—
—
—
0
0
70
45
17.53
82.42
1.1
1.0
—
—
—
0
0
50
17
32.06
75.98
1.2
1.1
275.0
—
ng/l
—
24
0
45
12
40.53
73.20
1.3
1.1
—
—
—
0
0
44
12
39.55
71.12
1.3
1.1
—
—
—
0
0
43
12
38.58
69.05
1.2
1.1
—
—
—
0
0
44
17
27.90
63.92
1.3
1.3
—
—
—
0
0
38
12
33.78
58.78
1.3
1.1
—
—
—
0
0
127
297
5.19
52.56
1.6
1.3
48.2
34.5
au/ml
—
5
14
34
12
30.01
50.69
1.4
1.1
—
—
—
0
0
130
334
4.72
47.76
2.9
2.4
43.1
16.2
au/ml
—
7
12
37
20
19.67
46.84
1.1
1.0
—
—
—
0
0
40
40
10.66
35.71
1.7
1.6
—
—
—
0
0
35
29
12.77
35.28
1.3
1.2
—
—
—
0
0
34
7
51.38
28.70
1.2
1.1
—
—
—
0
0
33
40
8.68
25.45
1.3
1.1
60.7
30.7
mg/l
1.95
26
30
29
31
9.79
24.57
1.2
1.1
1.3
1.1
u/l
0.55
17
17
152
664
2.74
23.13
2.0
1.9
—
—
—
0
0
29
34
8.92
22.92
1.8
1.7
—
—
—
0
0
29
35
8.66
22.41
1.1
1.0
—
—
—
0
0
27
8
35.27
21.28
1.3
1.4
—
—
—
0
0
53
131
4.35
19.86
1.5
1.1
—
—
—
0
0
325
2112
2.22
19.47
8.6
6.5
1.2
1.2
mmol/l
1.19
281
1780
28
39
7.49
19.21
1.1
1.1
332.5
215.3
mg/l
1.34
21
34
37
70
5.57
18.94
1.2
1.1
—
—
—
0
0
23
6
39.80
18.67
1.1
1.0
—
—
—
0
0
47
114
4.39
18.02
2.2
1.4
—
—
—
0
0
342
2339
2.12
17.11
7.2
6.0
10.7
10.7
umol/l
0.00
329
2216
24
32
7.77
17.06
1.9
2.0
10.6
12.6
%
—
7
19
369
2609
2.13
16.76
5.9
4.6
6.5
6.6
mmol/l
0.14
354
2411
293
1917
2.06
16.22
8.3
5.8
1.2
1.2
mmol/l
0.99
279
1752
51
146
3.73
15.61
2.1
1.8
1.2
3.3
ug/l
0.52
46
129
33
72
4.79
14.39
1.4
1.6
—
—
—
0
0
19
7
27.96
14.35
1.1
1.0
—
—
—
0
0
19
7
27.96
14.35
1.1
1.0
—
—
—
0
0
273
1813
1.95
13.78
5.8
4.6
35.5
36.2
g/l
0.90
259
1697
21
31
6.98
13.65
2.1
2.0
—
—
—
0
0
369
2718
1.98
13.63
11.0
8.9
4.3
4.0
e9/l
1.24
333
2376
13
10
13.26
13.39
1.0
1.1
—
—
—
0
0
30
65
4.81
13.18
1.3
1.1
—
—
—
0
0
99
452
2.43
13.18
2.0
1.8
—
—
—
0
0
23
39
6.09
13.13
2.2
2.1
658.8
695.7
e6/l
0.09
14
16
94
420
2.47
13.11
8.5
8.8
0.8
1.3
mmol/l
0.51
72
332
19
27
7.23
12.75
1.4
1.1
—
—
—
0
0
43
127
3.57
12.57
1.6
1.3
—
—
—
0
0
49
159
3.27
12.38
2.3
1.7
—
—
—
0
0
221
1405
1.92
12.37
2.7
2.4
48.7
55.3
u/l
3.64
210
1303
98
458
2.37
12.35
2.0
1.9
—
—
—
0
0
16
6
27.33
12.09
1.4
1.0
—
—
—
0
0
56
201
2.97
11.94
1.8
2.1
37.7
40.7
u/l
0.59
50
182
244
1619
1.87
11.85
3.4
3.3
21.7
58.8
ng/l
0.91
152
1022
436
3494
1.99
11.50
10.4
7.2
76.9
77.7
u/l
0.16
427
3276
71
304
2.52
10.78
1.8
1.6
—
—
—
0
0
14
17
8.41
10.64
2.4
2.0
—
—
—
0
0
48
170
2.99
10.47
1.9
1.9
—
—
—
0
0
385
3007
1.83
10.44
7.0
4.2
7700.6
1591.2
e6/l
—
8
47
11
10
11.18
10.18
2.3
1.8
—
—
—
0
0
56
223
2.67
9.84
1.7
1.7
—
—
—
0
0
86
423
2.21
9.52
3.2
4.4
232.5
259.9
u/l
0.69
81
404
121
678
1.99
9.49
4.7
3.7
0.8
0.8
mmol/l
0.42
115
639
77
369
2.25
9.06
3.9
3.6
1.6
1.9
mmol/l
0.39
68
291
59
254
2.47
8.84
1.5
1.4
—
—
—
0
0
226
1570
1.72
8.73
4.7
3.0
—
—
—
0
0
42
158
2.78
8.24
3.8
2.2
—
—
—
0
0
34
114
3.10
8.16
1.6
1.6
—
—
—
0
0
33
110
3.12
8.00
1.6
1.6
—
—
—
0
0
29
90
3.34
7.89
6.1
5.9
763.8
443.7
iu/ml
—
5
14
13
21
6.30
7.73
1.3
1.1
1293.8
1838.8
miu/ml
0.77
13
21
33
117
2.93
7.22
1.3
1.2
—
—
—
0
0
159
1052
1.70
7.09
1.9
1.7
1.4
1.1
mg/l
0.58
118
787
28
93
3.11
6.85
4.1
3.8
3.7
4.2
e9/l
0.43
28
93
126
792
1.75
6.72
3.7
3.5
128.1
293.7
ng/l
0.82
82
569
28
95
3.04
6.62
5.0
4.2
53.3
57.2
%
0.62
28
95
15
33
4.64
6.48
1.3
1.1
—
—
—
0
0
294
2300
1.56
6.46
7.2
4.7
0.0
0.0
estimate
0.00
56
457
32
121
2.74
6.25
2.9
2.5
—
—
—
0
0
277
2152
1.55
6.19
4.4
3.9
—
—
—
0
0
133
871
1.68
6.06
1.6
1.7
115200442.8
42683365.4
pmol/l
0.27
125
738
85
489
1.86
6.04
18.5
18.2
1.3
1.2
inr
0.11
12
76
9
6
15.19
5.91
1.1
1.3
—
—
—
0
0
294
2332
1.53
5.86
5.4
3.5
0.0
0.0
estimate
0.50
55
439
405
3449
1.57
5.78
5.8
3.9
12.4
10.6
mm/h
1.98
392
3189
24
82
3.01
5.63
1.5
1.6
—
—
—
0
0
155
1075
1.60
5.58
2.8
2.1
—
—
—
0
0
14
33
4.32
5.58
1.8
1.5
—
—
—
0
0
246
1896
1.51
5.51
3.0
2.3
75.5
75.2
nmol/l
0.07
233
1709
210
1569
1.53
5.43
3.6
3.3
32.9
31.2
u/l
0.42
203
1497
170
1212
1.57
5.43
4.7
2.9
0.3
0.4
e6/l
0.34
134
914
110
707
1.68
5.34
3.3
2.6
1.7
1.0
e6/l
0.52
64
387
286
2293
1.48
5.19
5.4
3.4
0.0
0.0
estimate
0.00
54
444
33
140
2.44
5.15
1.7
1.6
0.0
0.0
iu/ml
—
5
24
52
269
2.02
5.05
6.6
3.8
0.9
1.5
mmol/l
0.58
41
192
14
36
3.96
5.00
1.1
1.7
—
—
—
0
0
14
36
3.96
5.00
1.1
1.7
—
—
—
0
0
14
36
3.96
5.00
1.1
1.7
—
—
—
0
0
217
1659
1.49
4.92
2.1
1.9
102.2
95.3
pmol/l
1.01
119
858
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
101
2.65
4.86
4.2
2.4
0.4
0.4
u/ml
0.33
15
59
8
7
11.55
4.79
1.5
1.0
—
—
—
0
0
10
21
4.82
4.54
1.1
1.8
—
—
—
0
0
10
21
4.82
4.54
1.1
1.8
—
—
—
0
0
10
21
4.82
4.54
1.1
1.8
—
—
—
0
0
10
21
4.82
4.54
1.1
1.8
—
—
—
0
0
23
87
2.71
4.53
1.4
1.4
—
—
—
0
0
23
87
2.71
4.53
1.4
1.4
—
—
—
0
0
190
1441
1.47
4.39
3.4
3.0
2.3
2.4
mmol/l
0.41
168
1284
13
35
3.77
4.38
1.4
1.2
—
—
—
0
0
110
742
1.59
4.37
1.8
1.7
1313.6
1180.6
nmol/l
0.74
93
552
380
3281
1.45
4.35
4.3
3.1
55.2
42.0
u/l
1.49
371
3102
231
1821
1.44
4.35
5.5
3.5
—
—
—
0
0
56
320
1.83
4.08
2.1
2.3
4.7
6.8
ug/l
0.79
48
284
38
191
2.06
4.02
2.5
2.5
0.7
0.7
%
0.21
38
186
515
4772
1.69
3.95
22.9
12.4
23.2
21.4
mg/l
0.62
466
3682
100
676
1.58
3.93
3.5
2.8
2.6
2.7
e6/l
0.06
56
360
148
1116
1.44
3.41
2.8
2.6
337.5
6838.8
umol/l
4.37
142
969
20
82
2.49
3.41
1.1
1.1
—
—
—
0
0
18
70
2.62
3.40
1.5
1.6
—
—
—
0
0
19
76
2.55
3.40
2.1
1.7
—
—
—
0
0
27
127
2.18
3.40
1.6
1.3
10.1
2.6
u/ml
—
5
18
8
14
5.77
3.35
1.1
2.0
—
—
—
0
0
8
14
5.77
3.35
1.1
2.0
—
—
—
0
0
27
128
2.16
3.34
1.6
1.3
8.6
12.4
u/ml
—
9
26
20
83
2.46
3.33
1.1
1.1
—
—
—
0
0
20
83
2.46
3.33
1.4
1.2
2.5
4.2
u/ml
—
8
29
20
83
2.46
3.33
1.5
1.2
13.3
4.3
u/ml
—
8
36
509
4744
1.58
3.31
23.6
13.8
139.3
139.7
mmol/l
2.22
504
4618
145
1096
1.43
3.29
3.0
3.1
848.1
1023.5
ng/l
0.51
118
913
15
54
2.82
3.27
1.5
1.4
—
—
—
0
0
6
7
8.64
3.27
1.0
1.1
—
—
—
0
0
20
84
2.43
3.25
1.9
1.4
—
—
—
0
0
87
595
1.54
3.24
2.9
2.2
2.3
2.4
g/l
0.10
81
547
8
15
5.39
3.20
1.1
1.9
—
—
—
0
0
161
1248
1.40
3.16
6.2
3.7
0.0
0.0
estimate
0.69
52
446
509
4757
1.56
3.11
23.4
13.9
3.9
4.0
mmol/l
0.35
504
4620
75
501
1.57
3.10
6.5
6.4
—
—
—
0
0
12
39
3.12
3.10
1.5
1.3
—
—
—
0
0
12
40
3.04
2.98
1.5
1.3
—
—
—
0
0
48
293
1.69
2.85
2.3
3.0
178.3
163.9
ng/l
0.10
43
259
14
53
2.68
2.81
1.5
1.4
—
—
—
0
0
14
53
2.68
2.81
1.5
1.4
—
—
—
0
0
135
1035
1.40
2.80
5.1
3.6
1.0
1.0
kg/l
1.09
23
147
127
966
1.40
2.75
1.7
1.5
23.2
21.0
nmol/l
0.80
108
817
15
60
2.54
2.71
1.6
1.7
—
—
—
0
0
14
54
2.63
2.71
1.5
1.4
—
—
—
0
0
14
54
2.63
2.71
1.5
1.4
—
—
—
0
0
14
54
2.63
2.71
1.5
1.4
—
—
—
0
0
21
99
2.16
2.67
2.1
2.1
124.2
131.5
g/l
0.42
12
75
28
149
1.92
2.60
2.1
2.1
7.5
7.4
g/l
0.07
19
116
28
149
1.92
2.60
2.1
2.1
—
—
—
0
0
28
149
1.92
2.60
2.1
2.1
3.8
3.7
g/l
0.07
17
111
8
20
4.04
2.57
1.3
1.3
—
—
—
0
0
8
20
4.04
2.57
1.3
1.3
—
—
—
0
0
9
27
3.37
2.40
1.7
2.9
—
—
—
0
0
21
104
2.06
2.38
1.5
1.4
—
—
—
0
0
30
169
1.82
2.36
1.6
1.3
—
—
—
0
0
42
261
1.66
2.36
1.6
1.3
26.6
25.5
iu/l
0.07
36
219
10
35
2.89
2.31
1.6
1.2
—
—
—
0
0
77
553
1.45
2.29
3.2
2.3
22.1
23.4
%
0.27
64
480
6
13
4.65
2.27
1.2
1.2
—
—
—
0
0
7
18
3.92
2.25
1.1
1.4
—
—
—
0
0
20
100
2.03
2.23
1.6
1.4
233.5
238.0
u/ml
0.04
13
60
13
54
2.44
2.21
1.2
1.2
—
—
—
0
0
99
750
1.38
2.19
3.2
2.6
2.4
2.4
mmol/l
0.01
86
660
7
19
3.71
2.15
1.3
1.3
—
—
—
0
0
7
19
3.71
2.15
1.3
1.3
—
—
—
0
0
74
535
1.44
2.13
3.0
2.8
8.8
8.0
umol/l
0.11
62
463
13
55
2.39
2.13
1.2
1.1
—
—
—
0
0
471
4415
1.35
2.11
16.7
11.3
87.2
85.9
ml/min/173m2
0.61
412
3609
396
3630
1.28
2.07
4.9
4.0
14.8
14.6
pmol/l
0.73
371
3317
25
140
1.82
2.03
1.5
2.1
3.1
3.1
g/l
0.10
18
112
134
1076
1.32
2.03
2.4
2.1
3.1
3.0
mg/l
0.13
119
923
17
83
2.08
2.02
3.1
2.3
15.3
16.5
%
—
8
42
87
654
1.39
2.02
3.1
2.3
12.3
13.6
umol/l
1.21
82
592
5
11
4.57
1.94
1.0
1.0
—
—
—
0
0
526
5038
1.46
1.91
14.5
9.6
28.3
26.2
u/l
1.99
518
4890
69
509
1.40
1.80
4.3
4.1
32.9
31.6
%
0.40
50
337
14
67
2.11
1.77
2.1
1.6
—
—
—
0
0
6
18
3.35
1.75
1.2
1.4
—
—
—
0
0
6
18
3.35
1.75
2.3
1.7
123.0
58.0
ug/l
—
6
18
104
825
1.32
1.72
1.3
1.3
42.0
29.4
iu/ml
0.37
36
254
101
801
1.31
1.67
1.2
1.3
11.1
11.8
u/ml
0.04
37
324
373
3441
1.23
1.63
3.5
3.4
—
—
—
0
0
157
1327
1.25
1.57
3.4
3.0
7.5
7.8
mmol/l
0.31
139
1117
59
435
1.40
1.56
2.2
2.2
28.4
30.0
u/l
0.26
51
369
443
4173
1.26
1.55
5.7
5.3
39.5
39.3
mmol/mol
0.10
419
3912
18
101
1.81
1.50
1.5
1.3
—
—
—
0
0
57
422
1.39
1.48
3.5
3.3
—
—
—
0
0
9
38
2.39
1.46
2.4
2.4
—
—
—
0
0
44
312
1.44
1.45
5.5
3.6
87.3
75.2
ng/l
0.53
39
279
9
39
2.33
1.43
2.6
1.7
—
—
—
0
0
28
182
1.56
1.39
2.1
1.6
—
—
—
0
0
7
29
2.43
1.39
1.1
1.1
—
—
—
0
0
25
160
1.59
1.33
1.2
1.2
—
—
—
0
0
25
161
1.58
1.30
1.2
1.2
—
—
—
0
0
129
1095
1.23
1.24
1.9
1.6
—
—
—
0
0
11
56
1.98
1.22
2.4
1.6
—
—
—
0
0
19
117
1.64
1.19
1.6
2.3
0.0
0.0
g/l
0.34
19
109
5
113
0.44
1.13
2.2
1.6
—
—
—
0
0
14
81
1.74
1.09
1.6
1.5
0.3
0.4
nmol/l
—
9
66
20
128
1.58
1.09
1.3
1.4
225.5
316.0
ug/g
1.41
11
76
12
66
1.83
1.09
1.3
1.3
—
—
—
0
0
46
350
1.34
1.06
2.2
1.9
—
—
—
0
0
235
2134
1.17
1.06
3.4
2.8
113.8
99.4
ug/l
0.50
222
1982
7
33
2.13
1.05
1.9
1.4
8.3
10.7
u/l
—
7
12
5
22
2.28
1.03
1.2
1.9
—
—
—
0
0
5
22
2.28
1.03
1.2
1.9
—
—
—
0
0
24
163
1.49
1.03
2.0
1.7
—
—
—
0
0
141
1231
1.19
1.01
3.9
4.0
18.8
9.6
mg/mmol
0.66
90
781
15
93
1.63
0.94
1.3
1.7
—
—
—
0
0
8
144
0.55
0.94
2.0
1.8
—
—
—
0
0
7
37
1.90
0.94
4.7
3.0
—
—
—
0
0
10
57
1.77
0.84
1.8
1.6
—
—
—
0
0
10
57
1.77
0.84
1.0
1.1
1.4
1.5
g/l
—
10
50
16
105
1.54
0.82
1.6
1.3
—
—
—
0
0
6
32
1.88
0.82
1.5
1.2
—
—
—
0
0
38
484
0.77
0.81
1.8
1.7
—
—
—
0
0
86
734
1.20
0.81
1.9
2.1
—
—
—
0
0
78
661
1.21
0.79
1.6
1.8
1.5
1.4
%
0.55
67
589
449
4330
1.16
0.77
5.7
4.7
1.8
2.1
mu/l
0.60
423
3999
9
55
1.64
0.73
1.3
1.2
—
—
—
0
0
5
25
2.01
0.72
2.4
1.8
—
—
—
0
0
5
26
1.93
0.70
2.4
1.8
—
—
—
0
0
5
27
1.86
0.68
2.4
1.8
—
—
—
0
0
15
102
1.48
0.68
2.7
1.9
196.5
230.6
pmol/l
0.54
15
95
101
890
1.16
0.67
1.5
1.4
—
—
—
0
0
40
322
1.26
0.66
2.7
2.2
10.0
13.6
nmol/l
2.06
32
294
5
28
1.79
0.66
1.4
1.4
37277.4
44005.4
e6/l
—
5
13
54
638
0.83
0.63
2.7
2.8
0.7
0.7
ug/l
0.07
38
388
43
353
1.23
0.61
2.9
2.5
70.7
69.7
ml/min/173m2
0.05
18
154
5
30
1.67
0.61
4.0
3.2
—
—
—
0
0
26
203
1.29
0.56
1.3
1.3
227.9
236.2
miu/ml
0.04
11
102
11
73
1.52
0.56
1.4
2.6
2.8
60.5
u/ml
0.52
11
67
16
116
1.39
0.54
1.6
1.2
—
—
—
0
0
18
135
1.34
0.51
1.3
1.9
2.3
6.3
iu/l
—
5
48
24
189
1.28
0.50
1.5
1.4
—
—
—
0
0
15
111
1.36
0.47
1.8
2.3
0.0
0.0
g/l
0.00
15
103
37
311
1.20
0.45
1.1
1.3
—
—
—
0
0
25
306
0.81
0.44
1.1
1.0
—
—
—
0
0
51
443
1.16
0.44
2.6
2.0
—
—
—
0
0
45
389
1.17
0.41
1.3
1.2
136.7
161.4
iu/ml
0.13
18
163
89
808
1.12
0.41
2.1
2.3
—
—
—
0
0
5
33
1.52
0.41
2.4
1.8
—
—
—
0
0
5
34
1.47
0.40
6.6
2.7
67.0
102.1
%
—
5
34
30
251
1.20
0.39
2.3
2.3
918.3
2488.9
u/l
0.84
13
111
5
35
1.43
0.39
1.2
1.6
—
—
—
0
0
17
214
0.79
0.38
2.2
1.9
—
—
—
0
0
9
67
1.35
0.38
1.3
1.8
13.2
13.2
%
—
9
67
112
1207
0.91
0.38
1.7
1.6
1.6
1.4
mmol/l
0.90
100
1023
5
78
0.64
0.36
1.2
1.2
39.1
29.1
u/l
—
5
67
13
99
1.32
0.35
6.4
3.7
20.6
27.4
mg/l
—
5
62
6
43
1.40
0.35
2.0
1.5
53.7
49.6
%
—
6
31
22
181
1.22
0.34
1.3
1.4
—
—
—
0
0
22
181
1.22
0.34
1.3
1.4
—
—
—
0
0
6
44
1.37
0.34
1.2
1.0
—
—
—
0
0
6
44
1.37
0.34
1.3
1.2
—
—
—
0
0
6
44
1.37
0.34
1.3
1.2
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
22
182
1.22
0.33
1.3
1.4
—
—
—
0
0
22
182
1.22
0.33
1.3
1.4
—
—
—
0
0
14
110
1.28
0.31
1.9
2.3
0.0
0.0
g/l
0.00
14
103
29
336
0.86
0.31
1.5
1.5
—
—
—
0
0
8
63
1.27
0.28
1.4
1.2
0.5
0.5
nmol/l
—
8
56
452
4449
1.07
0.25
4.4
4.2
5.9
5.9
mmol/l
0.03
427
4095
451
4442
1.06
0.23
3.8
3.7
1.4
1.3
mmol/l
1.97
433
4129
25
218
1.15
0.23
1.4
1.4
—
—
—
0
0
469
4626
1.07
0.23
4.2
4.1
4.7
4.7
mmol/l
0.35
445
4322
44
401
1.10
0.22
3.6
4.0
2.6
17.7
ug/l
0.79
33
325
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
475
4696
1.06
0.18
4.7
4.5
2.8
2.8
mmol/l
0.15
448
4356
123
1178
1.05
0.18
1.3
1.3
1.6
1.4
u/ml
0.10
32
322
13
150
0.86
0.15
1.7
1.6
—
—
—
0
0
90
862
1.05
0.14
3.7
3.9
19.0
21.6
%
1.13
45
375
465
4609
1.04
0.12
4.2
4.0
1.5
1.5
mmol/l
0.00
440
4282
12
106
1.13
0.09
1.0
1.1
0.2
2.7
u/ml
—
5
42
12
106
1.13
0.09
1.6
2.4
96.1
145.4
ug/min
—
5
64
25
267
0.93
0.08
1.6
2.5
31.2
56.4
u/ml
0.68
25
255
451
4479
1.03
0.08
21.3
13.2
39.8
40.3
%
0.64
347
3459
7
84
0.83
0.07
1.0
1.2
—
—
—
0
0
21
197
1.07
0.06
1.3
1.5
—
—
—
0
0
17
164
1.04
0.00
2.0
1.5
—
—
—
0
0
107
1071
1.00
0.00
4.8
4.4
4.3
2.3
ug/l
0.42
102
961
10
95
1.05
0.00
1.8
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
11.3
—
0
5
0
5
0.00
0.00
0.0
2.8
—
5.4
—
0
5
0
5
0.00
0.00
0.0
3.4
—
0.6
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
59.2
—
0
6
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
0.00
1.6
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGOTH | 2.298 [1.88, 2.8] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1695 females with G6_MENINGOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGOTH | 2.392 [1.93, 2.96] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1631 males with G6_MENINGOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_MENINGOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.399% |
| 5 | 1.228% | 2.535% |
| 10 | 3.051% | 6.679% |
| 15 | 5.931% | 12.873% |
| 20 | 10.511% | 21.46% |
Relationships between endpoints
↥Index endpoint: G6_MENINGOTH – Other meningitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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