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Pterygium

DOID EFO Endpoint Browser PheWeb

H7_PTERYGIUM

pterygium: A wedge-shaped fibrovascular lesion arising from the bulbar conjunctiva and extending to the cornea. It is caused by chronic exposure to solar ultraviolet radiation, heat, and dust. It may cause severe vision loss. Studies have linked pterygium to neoplastic proliferation and suggest that it may be a stem cell disorder.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H11.0
  • Hospital discharge: ICD-9 — 3724
  • Hospital discharge: ICD-8 — 372
  • Cause of death: ICD-10 — H11.0
  • Cause of death: ICD-9 — 3724
  • Cause of death: ICD-8 — 372

2 out of 7 registries used, show all original rules.

1102

4. Check minimum number of events

None

1102

5. Include endpoints

None

1102

6. Filter based on genotype QC (FinnGen only)

1017

Control definitions (FinnGen only)

Control exclude
H7_CONJUNCTIVA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H11
Name in latin
Pterygium

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10019 3736 6008
Only index persons 8003 3281 4722
Unadjusted period prevalence (%)
Whole population 0.15 0.11 0.17
Only index persons 0.16 0.12 0.18
Median age at first event (years)
Whole population 59.38 58.25 60.83
Only index persons 58.52 56.95 59.61

-FinnGen-

Key figures

All Female Male
Number of individuals 1017 377 640
Unadjusted period prevalence (%) 0.23 0.13 0.29
Median age at first event (years) 61.96 58.33 64.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1102
Matched controls
11020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
+∞
321.0
292
*
H11.0
ICD-10 Finland
Pterygium
8933.6
307.7
949
7
CGE50
NOMESCO Finland
Excision of pterygium
+∞
196.9
183
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.6
133.8
718
3164
CG2S4
NOMESCO Finland
Photography of cornea
47.9
100.5
59
13
37299
ICD-8 Finland
Pterygium
+∞
99.5
94
*
3724A
ICD-9 Finland
Disorders of conjunctiva, Pterygium
+∞
93.1
88
*
3402
FHL
Local change removal and plastic (includes pterygium surgery)
+∞
89.8
85
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.8
60.7
534
2771
CD2S4
NOMESCO Finland
Photography of eye
25.9
57.1
40
16
S01GX01
ATC
cromoglicic acid; ophthalmic
3.7
55.7
201
620
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
57.2
37.6
44
8
XCK10
NOMESCO Finland
Photography of fundus of eye
3.1
37.4
183
673
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
35.9
151
507
CG2T4
NOMESCO Finland
Topography assessment of cornea
11.4
29.4
31
28
H16.0
ICD-10 Finland
Corneal ulcer
4.1
28.4
82
213
ZZU10
NOMESCO Finland
Free graft of conjunctiva
+∞
26.1
25
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
24.7
138
541
CF2S4
NOMESCO Finland
Photography of conjunctiva
49.6
24.4
29
6
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
22.7
100
343
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
19.9
190
949
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
71.2
18.8
21
*
CFD10
NOMESCO Finland
Repair of conjunctiva
193.2
18.6
19
*
H16.9
ICD-10 Finland
Keratitis, unspecified
5.9
17.2
31
54
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
15.7
210
1181
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.3
15.0
58
184
S01GX02
ATC
levocabastine; ophthalmic
3.7
14.9
48
135
S01XA18
ATC
ciclosporin; ophthalmic
21.4
14.7
21
10
H10.4
ICD-10 Finland
Chronic conjunctivitis
36.6
14.5
18
5
H02.1
ICD-10 Finland
Ectropion of eyelid
6.1
14.4
25
42
S01BA01
ATC
dexamethasone; ophthalmic
3.6
14.2
46
130
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
13.8
142
726
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.3
13.7
52
163
H11.4
ICD-10 Finland
Other conjunctival vascular disorders and cysts
+∞
12.5
12
*
H01.0
ICD-10 Finland
Blepharitis
2.8
12.4
62
228
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
12.6
12.1
21
17
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
11.3
698
5774
H17.8
ICD-10 Finland
Other corneal scars and opacities
15.7
10.8
17
11
S01GX08
ATC
ketotifen; ophthalmic
3.8
10.8
32
85
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
10.7
10.8
20
19
S01GX05
ATC
lodoxamide; ophthalmic
14.4
10.5
17
12
H57.1
ICD-10 Finland
Ocular pain
3.3
10.5
39
121
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
32.9
10.3
13
*
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
10.2
10.0
19
19
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
8.2
9.9
21
26
F29
ICPC
Eye symptom/complaint other
2.1
9.8
96
481
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.3
9.2
69
310
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
50.4
8.7
10
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.1
8.6
84
420
H18.4
ICD-10 Finland
Corneal degeneration
8.3
8.6
18
22
WX002
NOMESCO Finland
Sedation and analgesia
1.6
8.2
217
1464
S01GX09
ATC
olopatadine; ophthalmic
4.2
8.0
21
51
S01BA07
ATC
fluorometholone; ophthalmic
4.3
8.0
20
47
CFA20
NOMESCO Finland
Biopsy of conjunctiva
18.5
7.6
11
6
CGE10
NOMESCO Finland
Keratectomy
25.2
7.6
10
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
7.6
340
2568
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
80.6
7.4
8
*
H52.2
ICD-10 Finland
Astigmatism
3.8
7.4
22
59
A98
ICPC
Health maint/preventive medicine
1.8
7.3
995
9262
F73
ICPC
Eye infection/inflammation other
3.7
7.2
22
60
F13
ICPC
Eye sensation abnormal
2.9
7.2
32
111
F01
ICPC
Eye pain
3.1
7.2
29
95
H11.8
ICD-10 Finland
Other specified disorders of conjunctiva
20.2
7.1
10
5
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
4.2
7.0
18
43
ZXA10
NOMESCO Finland
Bilateral
1.5
6.7
200
1384
L01
ICPC
Neck symptom/complaint
1.7
6.7
130
811
H17.1
ICD-10 Finland
Other central corneal opacity
12.3
6.6
11
9
H10.8
ICD-10 Finland
Other conjunctivitis
10.1
6.5
12
12
ZXA00
NOMESCO Finland
Right side
1.5
6.5
291
2186
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.4
6.5
45
196
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.6
6.5
169
1134
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
6.4
251
1836
S29
ICPC
Skin symptom/complaint other
1.6
6.4
181
1237
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.4
112
680
H16.8
ICD-10 Finland
Other keratitis
18.1
6.3
9
5
3401
FHL
Removal of local modification or taking a specimen in the operating room
+∞
6.3
6
*
XCX10
NOMESCO Finland
Other photography of eye
26.8
6.2
8
*
S01KA02
ATC
hypromellose; ophthalmic
3.7
6.2
19
52

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
984
9074
1.79
8.21
18.0
19.7
3.98
4.00
mmol/l
1.49
950
8833
1014
9445
1.92
8.07
22.7
24.2
134.22
134.32
g/l
0.08
995
9277
1012
9441
1.88
7.70
22.5
24.0
91.10
91.60
fl
3.03
993
9274
1012
9442
1.88
7.69
22.6
24.1
6.76
6.84
e9/l
0.33
974
9149
1012
9442
1.88
7.69
22.5
24.0
30.29
30.46
pg
2.37
993
9273
1012
9443
1.88
7.67
22.6
24.1
4.46
4.44
e12/l
0.41
976
9151
988
9157
1.76
7.61
18.1
19.5
83.08
83.57
umol/l
0.13
988
9152
1011
9440
1.86
7.51
22.6
24.1
241.78
240.70
e9/l
0.22
976
9174
1010
9440
1.84
7.30
22.6
24.2
39.23
39.76
%
1.31
926
8717
976
9051
1.69
7.04
17.8
19.6
139.55
139.64
mmol/l
0.48
946
8819
926
8489
1.57
6.89
5.1
4.9
5.93
6.08
mmol/l
3.18
821
7629
702
6135
1.40
6.46
4.3
4.4
—
—
—
0
0
980
9142
1.65
6.35
10.6
11.0
26.01
25.79
u/l
0.11
935
8770
495
4106
1.37
6.16
5.2
5.8
57.52
58.23
%
0.58
461
3849
429
3479
1.38
6.13
2.2
2.2
—
—
—
0
0
496
4119
1.37
6.11
5.6
6.3
8.57
8.92
%
1.40
463
3851
494
4100
1.37
6.11
5.3
5.9
2.85
2.85
%
0.02
462
3831
501
4182
1.36
5.91
5.6
6.1
26.68
26.42
%
0.18
466
3921
927
8607
1.49
5.39
15.9
16.4
22.83
27.26
mg/l
3.69
745
6966
935
8702
1.49
5.31
5.5
5.2
2.71
2.61
mmol/l
2.82
844
7915
722
6445
1.35
5.16
4.7
4.1
12.57
13.76
mm/h
1.38
658
5901
473
3983
1.33
5.00
5.4
5.9
0.66
0.65
%
0.13
440
3714
907
8427
1.43
4.87
4.9
4.6
1.49
1.42
mmol/l
4.91
820
7654
508
4342
1.32
4.76
5.0
5.7
0.04
0.04
e9/l
0.70
440
3743
945
8866
1.46
4.63
14.8
15.8
—
—
—
0
0
521
4485
1.31
4.57
5.2
5.8
0.19
0.20
e9/l
0.10
454
3927
504
4332
1.30
4.42
5.0
5.6
0.60
0.61
e9/l
0.51
437
3728
910
8497
1.41
4.41
4.9
4.6
4.63
4.48
mmol/l
4.22
829
7789
513
4421
1.30
4.41
5.3
5.7
1.84
1.93
e9/l
0.36
452
3900
453
3852
1.30
4.27
9.6
10.3
0.00
0.00
e9/l
0.35
381
3172
842
7811
1.33
3.90
4.5
4.4
2.19
2.02
mu/l
0.49
749
7022
438
3740
1.28
3.90
4.6
4.0
60.80
57.24
ng/l
0.07
331
2880
93
613
1.56
3.88
2.5
3.0
—
—
—
0
0
347
2878
1.30
3.86
4.8
4.1
—
—
—
0
0
875
8167
1.35
3.86
6.0
6.3
40.47
40.75
mmol/mol
0.42
784
7486
693
6278
1.28
3.76
3.6
3.6
14.97
14.95
pmol/l
0.05
607
5611
660
5955
1.27
3.65
4.7
4.6
33.92
2387.96
e6/l
1.89
12
107
792
7315
1.29
3.60
17.5
19.5
15.38
15.34
%
0.05
777
7182
86
567
1.56
3.59
3.6
3.3
4.07
5.96
e9/l
1.01
66
456
492
4302
1.26
3.49
3.7
3.8
0.00
0.00
estimate
0.50
107
787
279
2276
1.30
3.47
3.4
3.6
—
—
—
0
0
84
1233
0.65
3.46
7.0
7.8
1.29
1.14
mmol/l
0.20
75
968
697
6375
1.25
3.23
4.0
4.2
—
—
—
0
0
80
533
1.54
3.22
1.3
1.3
—
—
—
0
0
865
8132
1.30
3.12
4.4
4.1
1.21
1.28
mmol/l
2.34
771
7343
39
669
0.57
3.09
8.2
9.2
1.20
1.37
%
0.47
39
663
481
4245
1.24
3.01
5.2
5.0
0.00
0.00
estimate
-0.00
109
821
22
102
2.18
2.88
1.2
1.2
—
—
—
0
0
481
4266
1.23
2.81
3.7
3.8
0.01
0.00
estimate
0.24
122
876
40
661
0.59
2.78
8.2
9.5
94.44
94.02
%
0.24
40
655
13
48
2.73
2.72
11.3
16.4
—
—
—
0
0
180
1429
1.31
2.70
1.5
1.5
2.50
2.69
g/l
0.60
100
854
462
4096
1.22
2.68
5.9
6.2
—
—
—
0
0
41
663
0.60
2.63
7.9
9.4
0.66
0.68
%
0.12
41
657
15
329
0.45
2.57
3.3
4.2
4.01
3.96
mmol/l
0.07
15
324
63
919
0.67
2.55
2.0
2.3
0.20
0.21
g/l
0.25
53
857
196
1591
1.28
2.49
1.3
1.2
1.85
1.59
u/ml
0.14
47
433
384
3363
1.22
2.47
3.4
3.5
5.86
5.76
ph
0.23
18
168
77
543
1.45
2.41
1.1
1.2
—
—
—
0
0
276
2350
1.23
2.32
1.7
1.6
1.26
1.35
mmol/l
1.25
224
1918
32
185
1.75
2.30
1.2
1.1
5.37
7.95
u/ml
—
8
14
105
793
1.36
2.24
4.8
4.2
1.22
1.22
mmol/l
0.16
94
684
36
218
1.67
2.21
1.8
2.0
8.31
12.66
mg/l
2.52
31
198
743
6969
1.20
2.18
7.1
7.8
82.00
80.48
u/l
0.25
695
6534
55
374
1.50
2.09
1.4
1.2
—
—
—
0
0
373
3303
1.20
2.07
3.8
3.9
54.16
136.67
e6/l
1.95
271
2441
599
5529
1.18
2.05
4.2
5.0
6.75
6.86
mmol/l
0.59
564
5226
16
76
2.12
2.03
1.1
1.1
0.56
1.24
u/ml
—
10
32
518
4730
1.18
2.00
15.2
18.2
1.35
1.35
inr
0.00
165
1335
70
504
1.42
2.00
3.3
3.9
—
—
—
0
0
475
4308
1.18
1.99
5.9
5.4
5.73
3.01
ug/l
0.56
417
3818
232
1973
1.22
1.96
2.7
3.1
551.92
551.79
mosm/kgh2o
0.00
203
1699
131
1044
1.29
1.94
1.4
1.3
907.06
490.09
titre
0.94
34
230
309
2704
1.20
1.94
3.1
3.1
—
—
—
0
0
70
509
1.40
1.90
2.6
2.4
—
—
—
0
0
216
1835
1.22
1.84
1.7
1.6
1.84
1.38
mg/l
0.46
167
1443
550
5077
1.17
1.79
7.5
9.0
4.10
4.25
e9/l
0.69
488
4429
107
841
1.30
1.77
2.0
2.2
125.09
140.86
ug/g
0.22
86
674
151
1240
1.25
1.77
1.3
1.2
—
—
—
0
0
52
724
0.70
1.70
5.1
5.2
—
—
—
0
0
328
2918
1.18
1.68
3.4
3.4
100.44
101.65
e6/l
0.01
260
2299
34
225
1.53
1.53
1.2
1.1
—
—
—
0
0
155
1301
1.22
1.50
1.4
1.3
39.77
39.17
iu/ml
0.02
43
410
37
251
1.49
1.49
1.3
1.5
343.68
274.16
ug/g
0.93
19
156
41
285
1.46
1.47
3.9
4.8
—
—
—
0
0
320
2870
1.16
1.46
2.4
2.2
188.14
269.31
u/l
1.18
298
2695
9
39
2.32
1.43
2.1
2.3
33423.56
39379.62
ug/l
—
9
39
296
2647
1.16
1.40
3.3
3.3
0.26
0.53
e6/l
3.38
235
2062
275
2457
1.16
1.32
2.6
2.8
11891.40
7248.25
umol/l
0.48
229
2125
429
3956
1.14
1.30
2.0
2.1
94.22
93.36
pmol/l
0.11
219
2109
36
252
1.44
1.27
1.6
1.6
—
—
—
0
0
15
84
1.80
1.27
1.1
1.0
10.13
2.23
u/ml
—
7
33
103
845
1.24
1.26
1.5
1.6
—
—
—
0
0
179
1552
1.18
1.25
3.2
3.1
2.08
1.54
e6/l
0.26
111
918
29
420
0.68
1.23
4.0
4.6
—
—
—
0
0
33
229
1.45
1.23
3.7
3.9
36.32
29.62
mg/l
0.38
22
143
274
2463
1.15
1.21
3.6
3.3
0.81
0.80
ug/l
0.06
200
1749
204
1801
1.16
1.15
2.7
3.1
2.45
2.46
mmol/l
0.32
176
1579
116
975
1.21
1.14
1.2
1.3
—
—
—
0
0
7
30
2.34
1.12
1.4
2.2
3.41
8.29
nmol/l
—
7
24
93
766
1.23
1.12
3.7
4.0
—
—
—
0
0
88
722
1.24
1.10
4.6
4.3
0.04
0.10
%
0.88
28
252
5
21
2.39
1.09
2.0
1.4
—
—
—
0
0
5
21
2.39
1.09
1.6
2.0
134.74
90.19
nmol/24h
—
5
21
124
1060
1.19
1.04
1.6
1.8
—
—
—
0
0
16
99
1.63
1.00
1.3
1.3
—
0.46
nmol/l
—
0
8
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.4
—
21.24
—
0
21
69
844
0.81
0.97
6.7
8.7
—
—
—
0
0
9
50
1.81
0.96
2.0
4.0
13.27
13.16
%
—
9
50
102
865
1.20
0.95
1.6
1.5
—
—
—
0
0
11
62
1.78
0.94
1.3
1.1
—
—
—
0
0
15
93
1.62
0.94
1.3
1.3
—
—
—
0
0
10
55
1.83
0.92
1.0
1.0
—
—
—
0
0
82
684
1.21
0.91
4.8
4.4
0.04
0.50
%
0.60
24
220
207
1864
1.14
0.90
4.3
3.9
905.93
331.66
ng/l
0.80
177
1566
5
101
0.49
0.89
1.2
1.2
—
—
—
0
0
376
3509
1.11
0.88
2.3
2.2
81.91
77.86
nmol/l
1.79
323
3086
47
369
1.29
0.88
2.6
2.6
9.18
10.71
g/l
2.07
40
333
91
770
1.20
0.88
4.6
4.2
0.76
0.92
%
0.26
31
298
11
64
1.73
0.86
1.0
1.0
0.80
0.67
u/ml
—
5
17
16
239
0.66
0.85
1.1
1.2
—
440.00
—
0
6
67
807
0.82
0.84
3.6
3.3
—
—
—
0
0
138
1562
0.87
0.84
2.6
3.3
0.83
0.82
mmol/l
0.56
129
1464
86
728
1.20
0.83
2.3
2.7
—
—
—
0
0
333
3098
1.11
0.83
3.0
3.5
2.34
2.34
mmol/l
0.00
277
2719
20
138
1.46
0.82
1.4
1.4
118.38
100.01
u/ml
—
8
24
14
89
1.58
0.81
1.2
1.2
—
—
—
0
0
82
695
1.19
0.79
3.8
4.1
0.50
0.58
%
0.17
26
259
89
760
1.19
0.79
1.6
1.5
—
—
—
0
0
274
2960
0.90
0.79
2.9
3.3
270.31
278.39
mg/l
0.01
165
1995
0
26
0.00
0.78
0.0
1.1
—
1.58
—
0
19
14
90
1.56
0.78
1.2
1.3
—
—
nmol/l
—
0
0
13
82
1.59
0.78
2.0
2.0
4.50
2.40
u/field
—
6
30
139
1234
1.14
0.76
1.3
1.3
3.85
13.10
u/ml
3.12
39
440
30
392
0.76
0.76
3.2
3.5
40.60
3743.28
u/ml
0.81
25
330
18
124
1.46
0.75
1.1
1.1
—
—
—
0
0
55
451
1.23
0.75
1.1
1.2
—
—
—
0
0
181
1638
1.13
0.74
3.2
2.9
0.70
1.11
e6/l
2.27
112
997
7
38
1.85
0.73
1.3
1.4
—
—
—
0
0
7
38
1.85
0.73
1.3
1.4
—
—
—
0
0
9
55
1.64
0.73
1.6
1.2
—
—
—
0
0
283
3040
0.91
0.73
2.8
3.2
7.09
7.53
mmol/l
1.14
232
2537
80
932
0.85
0.72
6.6
7.2
9.73
10.86
mmol/l
0.64
73
884
34
264
1.30
0.72
1.1
1.1
—
—
—
0
0
330
3091
1.10
0.71
3.3
3.1
1383.81
1692.33
ng/l
1.16
286
2688
7
40
1.75
0.71
1.3
1.6
—
—
—
0
0
11
170
0.64
0.71
2.7
1.5
—
—
—
0
0
273
2536
1.10
0.70
3.3
3.3
—
—
—
0
0
134
1195
1.14
0.70
1.5
1.3
—
—
—
0
0
9
144
0.62
0.70
1.6
1.3
—
—
—
0
0
235
2168
1.11
0.69
6.1
6.9
—
—
—
0
0
46
374
1.24
0.69
2.4
3.1
0.18
0.27
g/l
0.80
19
147
22
161
1.37
0.68
3.3
3.0
5.53
4.58
e9/l
0.64
22
161
5
27
1.86
0.68
1.2
1.0
—
—
—
0
0
11
69
1.60
0.68
1.1
1.0
1.46
2.53
u/ml
—
5
23
7
42
1.67
0.68
2.1
2.4
770.86
1605.26
u/ml
—
7
42
82
708
1.17
0.67
2.5
2.2
12.19
12.27
nmol/l
0.02
71
626
18
128
1.41
0.66
1.1
1.1
—
—
—
0
0
14
95
1.48
0.64
2.3
1.8
3344.88
1197.55
u/l
—
5
31
95
834
1.15
0.63
1.4
1.4
—
—
—
0
0
118
1052
1.14
0.63
1.6
1.4
—
—
—
0
0
8
50
1.60
0.61
1.4
1.8
49.74
36.94
%
—
8
50
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
26
202
1.29
0.57
2.6
2.8
—
—
—
0
0
428
4088
1.08
0.57
3.8
5.0
35.04
34.77
g/l
0.45
381
3796
93
1048
0.88
0.57
2.2
2.7
7.42
9.60
umol/l
1.24
70
921
5
87
0.57
0.56
1.2
1.2
—
—
—
0
0
44
366
1.21
0.56
1.7
1.5
—
—
—
0
0
56
477
1.18
0.56
1.4
1.4
—
—
—
0
0
296
3135
0.92
0.55
3.4
3.8
3.92
8.64
mg/mmol
4.61
180
2059
156
1428
1.11
0.55
2.4
2.5
2.31
2.26
g/l
0.60
140
1323
22
168
1.32
0.55
1.8
1.5
—
—
—
0
0
555
5358
1.07
0.55
3.1
3.2
47.46
54.75
u/l
1.41
511
4944
19
142
1.34
0.54
2.8
2.7
—
—
—
0
0
214
2295
0.92
0.54
2.4
2.5
—
—
—
0
0
21
160
1.32
0.53
1.4
1.3
—
—
—
0
0
9
61
1.48
0.53
1.0
1.1
—
—
—
0
0
22
169
1.31
0.53
3.4
3.3
62.91
59.44
%
0.51
22
169
98
876
1.13
0.53
2.7
2.9
66.63
66.21
g/l
0.24
89
803
20
259
0.77
0.51
1.7
2.4
40.47
116.10
ug/min
—
10
158
63
548
1.16
0.50
2.9
3.0
0.17
0.29
e6/l
0.78
63
535
43
508
0.84
0.50
1.4
1.8
1.35
1.54
g/l
0.86
35
445
215
2294
0.92
0.49
1.4
1.3
—
—
—
0
0
28
227
1.24
0.47
1.8
2.3
130.24
128.92
g/l
0.07
21
168
27
218
1.24
0.47
3.2
5.1
2.63
2.55
mmol/l
0.05
18
150
8
120
0.66
0.45
1.3
1.4
—
—
—
0
0
267
2530
1.07
0.44
2.1
2.2
2.89
3.05
mg/l
0.46
230
2156
417
4330
0.94
0.44
2.7
2.7
—
—
—
0
0
299
2847
1.07
0.43
3.4
3.2
—
—
—
0
0
216
2033
1.08
0.43
2.6
2.7
3.52
4.61
e6/l
1.19
196
1837
11
78
1.41
0.43
1.0
1.2
—
—
—
0
0
8
56
1.43
0.42
1.1
1.3
—
—
—
0
0
251
2378
1.07
0.42
1.5
1.6
21.13
19.97
nmol/l
0.50
215
2016
16
122
1.32
0.42
1.0
1.2
—
—
—
0
0
47
407
1.16
0.42
1.3
1.3
—
—
—
0
0
253
2400
1.07
0.41
3.9
4.1
0.01
0.00
estimate
0.24
103
775
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
153.61
—
0
12
5
34
1.47
0.40
1.2
1.1
—
113.57
—
0
7
146
1359
1.09
0.39
2.5
2.6
22.12
23.03
%
0.34
118
1160
50
569
0.87
0.39
6.5
8.0
24.89
24.67
mmol/l
0.21
50
564
15
115
1.31
0.39
1.4
1.2
—
—
—
0
0
211
1995
1.07
0.38
3.6
3.7
—
—
—
0
0
24
197
1.22
0.38
1.3
1.2
—
—
—
0
0
50
567
0.88
0.38
6.6
10.9
—
—
—
0
0
151
1411
1.08
0.37
1.8
2.1
—
—
—
0
0
19
235
0.81
0.37
1.6
1.6
12699.15
17806.26
e6/l
0.23
13
171
17
134
1.27
0.37
1.1
1.3
98.58
203.85
miu/ml
—
8
50
15
191
0.78
0.37
1.1
1.2
4.07
3.78
mmol/l
0.57
15
176
109
1006
1.09
0.36
1.8
1.6
—
—
—
0
0
9
71
1.27
0.36
1.2
1.3
—
—
—
0
0
20
162
1.24
0.35
2.4
2.5
—
—
—
0
0
5
79
0.63
0.35
1.6
1.1
—
—
—
0
0
16
126
1.27
0.35
1.1
1.1
—
—
—
0
0
26
218
1.20
0.34
1.8
2.8
16.86
15.82
%
0.47
14
116
373
3605
1.05
0.33
2.7
2.8
145.62
153.99
ug/l
0.27
331
3282
44
388
1.14
0.33
1.7
1.9
—
—
—
0
0
487
4741
1.05
0.32
6.1
7.2
1.22
1.21
mmol/l
1.49
420
4029
6
47
1.28
0.32
1.0
1.0
—
—
—
0
0
499
4864
1.05
0.31
5.4
6.4
11.23
12.16
umol/l
1.57
467
4633
7
52
1.35
0.31
1.0
1.5
73.43
88.71
umol/l
—
7
52
42
473
0.88
0.30
2.0
1.9
1.17
1.89
ug/l
0.35
36
418
7
55
1.27
0.30
1.7
1.6
—
—
—
0
0
26
222
1.18
0.29
2.5
4.0
—
—
—
0
0
11
141
0.78
0.29
1.1
1.3
19918.83
71179.72
e6/l
—
6
81
53
478
1.11
0.29
2.3
2.8
—
—
—
0
0
35
307
1.14
0.29
2.3
2.5
38.00
37.39
g/l
0.25
27
272
83
767
1.09
0.29
1.6
1.5
—
—
—
0
0
20
167
1.20
0.28
1.3
2.1
1.60
1.67
mmol/l
0.17
20
161
39
347
1.13
0.27
2.3
3.7
30.95
76.93
mg/l
1.80
34
281
298
2882
1.05
0.26
4.0
4.5
—
—
—
0
0
11
86
1.28
0.26
1.1
1.5
—
—
—
0
0
42
467
0.90
0.26
1.2
1.4
—
—
—
0
0
23
197
1.17
0.26
1.0
1.1
—
—
—
0
0
9
75
1.20
0.25
2.4
2.5
—
—
—
0
0
28
245
1.15
0.25
2.9
2.9
7.71
7.83
kpa
0.12
28
239
9
77
1.17
0.24
1.0
1.3
—
35.33
—
0
6
294
2852
1.04
0.23
2.6
2.6
60.19
87.99
u/l
0.49
261
2657
24
274
0.87
0.22
3.3
3.6
—
—
—
0
0
87
925
0.94
0.22
3.9
2.5
8.38
6.99
ug/l
0.28
72
817
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
162
1554
1.05
0.21
2.4
2.5
12.34
12.69
umol/l
0.27
146
1447
45
491
0.91
0.21
3.6
3.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
7.58
—
0
6
118
1239
0.95
0.20
3.0
2.4
1.57
1.78
%
1.54
103
1100
0
14
0.00
0.20
0.0
1.4
—
34.43
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
9
114
0.79
0.20
1.1
1.1
—
—
—
0
0
19
218
0.87
0.19
2.3
2.9
—
—
—
0
0
88
930
0.94
0.19
2.5
2.7
66.69
68.31
e9/l
0.15
68
738
60
643
0.93
0.19
1.4
1.4
—
—
—
0
0
201
1944
1.04
0.19
1.7
1.8
1016.55
1168.41
nmol/l
2.01
151
1486
21
238
0.88
0.18
3.3
3.0
0.92
0.84
nmol/l
0.60
14
184
12
100
1.20
0.18
1.8
1.3
41.98
50.26
mu/l
0.15
12
86
38
348
1.10
0.18
2.3
3.7
21.87
97.23
mg/l
1.28
33
284
7
59
1.19
0.18
2.0
1.9
—
—
—
0
0
103
1080
0.95
0.18
3.3
4.2
32.98
26.32
ug/l
0.10
83
913
7
60
1.17
0.18
1.4
1.6
—
—
—
0
0
7
60
1.17
0.18
1.1
1.1
—
—
—
0
0
27
243
1.11
0.17
2.1
2.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.1
—
—
—
0
0
13
152
0.85
0.17
1.8
1.4
—
—
—
0
0
15
173
0.87
0.16
1.3
1.3
54.20
64.05
mmol/l
—
10
146
8
72
1.11
0.16
1.0
1.3
—
—
—
0
0
9
78
1.16
0.15
1.1
1.2
—
—
—
0
0
81
771
1.05
0.15
2.1
2.1
362.28
367.75
nmol/l
0.07
72
709
9
79
1.14
0.15
1.1
1.2
—
—
—
0
0
31
285
1.09
0.14
2.8
3.1
24.76
24.83
mmol/l
0.04
31
278
8
98
0.81
0.13
3.3
3.1
—
—
—
0
0
26
238
1.09
0.13
2.3
1.7
—
—
—
0
0
285
2797
1.03
0.12
3.0
3.3
31.58
34.74
u/l
0.55
271
2660
98
945
1.04
0.12
4.1
4.7
—
—
—
0
0
69
720
0.96
0.11
2.7
3.9
95.10
96.02
ng/l
0.02
58
630
10
86
1.16
0.11
1.4
1.6
—
—
—
0
0
193
1889
1.03
0.10
4.0
4.2
1.02
1.02
kg/l
0.39
39
282
65
678
0.96
0.10
3.6
3.7
7.43
7.41
ph
—
7
94
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
10
114
0.88
0.09
3.2
2.4
—
—
—
0
0
6
55
1.09
0.09
2.3
2.9
1573.33
1811.70
ml
—
6
47
6
55
1.09
0.09
1.0
1.3
136.50
143.99
nmol/l
—
6
55
295
2988
0.98
0.08
2.6
2.5
—
—
—
0
0
14
154
0.91
0.08
1.6
1.3
—
—
—
0
0
27
287
0.94
0.08
8.0
11.7
—
—
—
0
0
44
424
1.04
0.06
1.0
1.1
153.20
145.82
iu/ml
0.03
13
162
16
172
0.93
0.06
1.5
1.7
—
—
—
0
0
17
159
1.07
0.05
1.6
1.7
2.72
4.96
iu/l
—
6
50
18
169
1.07
0.05
1.6
1.2
—
—
—
0
0
43
416
1.04
0.05
2.6
3.2
4.53
4.44
pmol/l
0.26
38
364
13
120
1.08
0.05
3.2
2.6
—
—
—
0
0
13
120
1.08
0.05
1.2
1.3
—
—
—
0
0
431
4336
0.99
0.04
5.1
6.4
1.21
1.21
mmol/l
0.77
393
3963
21
199
1.06
0.04
1.2
1.2
—
—
—
0
0
131
1328
0.98
0.04
4.9
5.6
1.00
1.02
mmol/l
0.45
118
1231
25
239
1.05
0.04
1.4
1.6
—
—
—
0
0
13
121
1.08
0.03
1.2
1.3
—
—
—
0
0
24
250
0.96
0.03
1.1
1.2
—
—
—
0
0
10
92
1.09
0.03
1.0
1.1
—
—
—
0
0
13
122
1.07
0.02
1.2
1.3
—
—
—
0
0
13
122
1.07
0.02
1.2
1.3
—
—
—
0
0
33
339
0.97
0.02
1.6
1.4
—
—
—
0
0
13
137
0.95
0.01
1.1
1.6
—
—
—
0
0
213
2122
1.00
0.01
1.8
1.8
422.66
21912769.96
pmol/l
1.76
164
1757
10
94
1.06
0.01
1.2
1.4
—
—
—
0
0
11
116
0.95
0.00
1.2
1.3
—
—
—
0
0
15
144
1.04
0.00
1.5
1.4
—
—
—
0
0
16
154
1.04
0.00
2.1
1.7
293.25
272.90
mu/l
0.16
16
143
27
264
1.02
0.00
1.8
3.8
—
—
—
0
0
13
134
0.97
0.00
1.1
1.4
—
—
—
0
0
10
98
1.02
0.00
1.2
1.4
—
—
—
0
0
12
118
1.02
0.00
8.7
5.0
—
—
—
0
0
280
2799
1.00
0.00
3.7
4.2
7.40
7.40
ph
0.92
62
534
12
117
1.03
0.00
3.0
1.9
—
—
—
0
0
96
959
1.00
0.00
3.7
3.6
1.57
1.95
mmol/l
0.45
85
779
19
193
0.98
0.00
1.7
1.6
—
—
—
0
0
83
829
1.00
0.00
2.0
2.3
28.99
34.91
u/l
1.89
75
696
30
295
1.02
0.00
1.2
1.2
—
—
—
0
0
15
145
1.03
0.00
2.6
2.7
—
—
—
0
0
15
145
1.03
0.00
1.4
1.2
274.56
264.22
u/ml
—
9
78
18
185
0.97
0.00
2.3
2.2
—
—
—
0
0
17
165
1.03
0.00
5.1
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
57
0.88
0.00
2.2
1.7
—
46.96
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
330.60
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
0.92
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
82
0.98
-0.00
2.1
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.1
45.10
44.10
mg/l
—
5
49
6
62
0.97
-0.00
2.0
2.7
—
—
—
0
0
5
54
0.93
-0.00
1.2
1.1
326.00
274.45
mg/l
—
5
49
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
54
0.93
-0.00
1.6
1.5
0.99
0.99
g/l
—
5
54
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_PTERYGIUM and mortality.

Females

Parameter HR [95% CI] p-value
H7_PTERYGIUM 0.801 [0.69, 0.92] 0.002
Birth year 0.993 [0.98, 1.0] 0.096

During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 2393 females with H7_PTERYGIUM died.

Males

Parameter HR [95% CI] p-value
H7_PTERYGIUM 0.781 [0.7, 0.87] < 0.001
Birth year 0.993 [0.98, 1.0] 0.137

During the follow-up period (1.1.1998 — 31.12.2019), 750 out of 3406 males with H7_PTERYGIUM died.

Mortality risk

Mortality risk for people of age

years, who have H7_PTERYGIUM.

N-year risk Females Males
1 0.067% 0.156%
5 0.458% 1.033%
10 1.213% 2.673%
15 2.145% 5.331%
20 3.639% 9.071%

Relationships between endpoints

↥

Index endpoint: H7_PTERYGIUM – Pterygium

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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