pterygium: A wedge-shaped fibrovascular lesion arising from the bulbar conjunctiva and extending to the cornea. It is caused by chronic exposure to solar ultraviolet radiation, heat, and dust. It may cause severe vision loss. Studies have linked pterygium to neoplastic proliferation and suggest that it may be a stem cell disorder.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1052 |
4. Check minimum number of eventsNone |
1052 |
5. Include endpointsNone |
1052 |
6. Filter based on genotype QC (FinnGen only) |
1052 |
Control definitions (FinnGen only)
- Control exclude
- H7_CONJUNCTIVA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H11
- Name in latin
- Pterygium
Similar endpoints
↥List of similar endpoints to
Pterygium
based on the number of shared cases.
Similar with more cases:
- Other disorders of conjunctiva
- Disorders of conjunctiva
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10019 | 3736 | 6008 |
| Only index persons | 8003 | 3281 | 4722 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.11 | 0.17 |
| Only index persons | 0.16 | 0.12 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 59.38 | 58.25 | 60.83 |
| Only index persons | 58.52 | 56.95 | 59.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1052 | 394 | 658 |
| Unadjusted period prevalence (%) | 0.23 | 0.13 | 0.29 |
| Median age at first event (years) | 60.53 | 56.76 | 62.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 924
- Matched controls
- 9242
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H11.0
ICD-10 Finland
Pterygium
14489.1
323.0
782
*
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
+∞
251.9
230
*
CGE50
NOMESCO Finland
Excision of pterygium
+∞
167.9
156
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.7
105.4
575
2399
37299
ICD-8 Finland
Pterygium
+∞
91.2
86
*
3724A
ICD-9 Finland
Disorders of conjunctiva, Pterygium
+∞
86.8
82
*
3402
FHL
Local change removal and plastic (includes pterygium surgery)
+∞
82.5
78
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.0
53.1
450
2209
CG2S4
NOMESCO Finland
Photography of cornea
137.5
49.3
52
*
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
73.1
37.2
42
6
S01GX01
ATC
cromoglicic acid; ophthalmic
3.6
31.7
157
495
XCK10
NOMESCO Finland
Photography of fundus of eye
3.3
29.0
161
552
CF2S4
NOMESCO Finland
Photography of conjunctiva
89.1
23.8
26
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
21.3
106
331
H16.0
ICD-10 Finland
Corneal ulcer
4.9
20.1
67
145
CFD10
NOMESCO Finland
Repair of conjunctiva
193.7
18.6
19
*
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
172.9
16.5
17
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
16.2
116
461
CG2T4
NOMESCO Finland
Topography assessment of cornea
18.1
15.2
23
13
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
14.5
81
274
CD2S4
NOMESCO Finland
Photography of eye
15.0
13.6
22
15
ZZU10
NOMESCO Finland
Free graft of conjunctiva
+∞
13.6
13
*
H16.9
ICD-10 Finland
Keratitis, unspecified
8.9
13.0
27
31
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
22.9
12.9
18
8
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
12.1
133
662
H10.4
ICD-10 Finland
Chronic conjunctivitis
30.4
11.7
15
5
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
14.4
10.5
17
12
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.9
10.5
42
111
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
10.4
154
862
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
40.5
10.0
12
*
H57.1
ICD-10 Finland
Ocular pain
4.5
9.9
34
78
WX110
NOMESCO Finland
Local anesthesy
1.6
9.8
554
4516
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
3.7
9.1
39
110
H11.4
ICD-10 Finland
Other conjunctival vascular disorders and cysts
50.5
8.7
10
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
8.6
110
579
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
+∞
8.3
8
*
ZXA00
NOMESCO Finland
Right side
1.6
8.3
255
1777
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
33.6
8.1
10
*
ZXA10
NOMESCO Finland
Bilateral
1.7
8.0
165
1026
S01GX02
ATC
levocabastine; ophthalmic
3.2
7.9
39
124
H02.1
ICD-10 Finland
Ectropion of eyelid
5.1
7.8
23
46
CGE10
NOMESCO Finland
Keratectomy
45.3
7.7
9
*
S01GX05
ATC
lodoxamide; ophthalmic
12.0
7.6
13
11
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
12.0
7.6
13
11
H18.4
ICD-10 Finland
Corneal degeneration
12.0
7.6
13
11
H11.8
ICD-10 Finland
Other specified disorders of conjunctiva
80.7
7.4
8
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
80.7
7.4
8
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
7.2
299
2226
CFA20
NOMESCO Finland
Biopsy of conjunctiva
30.2
7.2
9
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
30.2
7.2
9
*
H17.1
ICD-10 Finland
Other central corneal opacity
20.2
7.1
10
5
H01.0
ICD-10 Finland
Blepharitis
2.7
6.8
44
168
S01GX09
ATC
olopatadine; ophthalmic
6.2
6.8
17
28
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.7
178
1189
ZXA05
NOMESCO Finland
Left side
1.5
6.4
235
1692
H25.8
ICD-10 Finland
Other senile cataract
1.8
6.3
108
633
3401
FHL
Removal of local modification or taking a specimen in the operating room
+∞
6.3
6
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.1
6.0
64
314
Mortality – FinRegistry
↥Association
Association between endpoint H7_PTERYGIUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTERYGIUM | 0.801 [0.69, 0.92] | 0.002 |
| Birth year | 0.993 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 2393 females with H7_PTERYGIUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTERYGIUM | 0.781 [0.7, 0.87] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 750 out of 3406 males with H7_PTERYGIUM died.
Mortality risk
Mortality risk for people of age
years, who have H7_PTERYGIUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.067% | 0.156% |
| 5 | 0.458% | 1.033% |
| 10 | 1.213% | 2.673% |
| 15 | 2.145% | 5.331% |
| 20 | 3.639% | 9.071% |
Relationships between endpoints
↥Index endpoint: H7_PTERYGIUM – Pterygium
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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