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Pterygium

DOID EFO Endpoint Browser PheWeb

H7_PTERYGIUM

pterygium: A wedge-shaped fibrovascular lesion arising from the bulbar conjunctiva and extending to the cornea. It is caused by chronic exposure to solar ultraviolet radiation, heat, and dust. It may cause severe vision loss. Studies have linked pterygium to neoplastic proliferation and suggest that it may be a stem cell disorder.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H11.0
  • Hospital discharge: ICD-9 — 3724
  • Hospital discharge: ICD-8 — 372
  • Cause of death: ICD-10 — H11.0
  • Cause of death: ICD-9 — 3724
  • Cause of death: ICD-8 — 372

2 out of 7 registries used, show all original rules.

1052

4. Check minimum number of events

None

1052

5. Include endpoints

None

1052

6. Filter based on genotype QC (FinnGen only)

1052

Control definitions (FinnGen only)

Control exclude
H7_CONJUNCTIVA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H11
Name in latin
Pterygium

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10019 3736 6008
Only index persons 8003 3281 4722
Unadjusted period prevalence (%)
Whole population 0.15 0.11 0.17
Only index persons 0.16 0.12 0.18
Median age at first event (years)
Whole population 59.38 58.25 60.83
Only index persons 58.52 56.95 59.61

-FinnGen-

Key figures

All Female Male
Number of individuals 1052 394 658
Unadjusted period prevalence (%) 0.23 0.13 0.29
Median age at first event (years) 60.53 56.76 62.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
924
Matched controls
9242
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H11.0
ICD-10 Finland
Pterygium
14489.1
323.0
782
*
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
+∞
251.9
230
*
CGE50
NOMESCO Finland
Excision of pterygium
+∞
167.9
156
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.7
105.4
575
2399
37299
ICD-8 Finland
Pterygium
+∞
91.2
86
*
3724A
ICD-9 Finland
Disorders of conjunctiva, Pterygium
+∞
86.8
82
*
3402
FHL
Local change removal and plastic (includes pterygium surgery)
+∞
82.5
78
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.0
53.1
450
2209
CG2S4
NOMESCO Finland
Photography of cornea
137.5
49.3
52
*
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
73.1
37.2
42
6
S01GX01
ATC
cromoglicic acid; ophthalmic
3.6
31.7
157
495
XCK10
NOMESCO Finland
Photography of fundus of eye
3.3
29.0
161
552
CF2S4
NOMESCO Finland
Photography of conjunctiva
89.1
23.8
26
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
21.3
106
331
H16.0
ICD-10 Finland
Corneal ulcer
4.9
20.1
67
145
CFD10
NOMESCO Finland
Repair of conjunctiva
193.7
18.6
19
*
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
172.9
16.5
17
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
18.1
15.2
23
13
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
14.5
81
274
CD2S4
NOMESCO Finland
Photography of eye
15.0
13.6
22
15
ZZU10
NOMESCO Finland
Free graft of conjunctiva
+∞
13.6
13
*
H16.9
ICD-10 Finland
Keratitis, unspecified
8.9
13.0
27
31
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
22.9
12.9
18
8
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
12.1
133
662
H10.4
ICD-10 Finland
Chronic conjunctivitis
30.4
11.7
15
5
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
14.4
10.5
17
12
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.9
10.5
42
111
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
10.4
154
862
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
40.5
10.0
12
*
H57.1
ICD-10 Finland
Ocular pain
4.5
9.9
34
78
WX110
NOMESCO Finland
Local anesthesy
1.6
9.8
554
4516
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
3.7
9.1
39
110
H11.4
ICD-10 Finland
Other conjunctival vascular disorders and cysts
50.5
8.7
10
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
8.6
110
579
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
+∞
8.3
8
*
ZXA00
NOMESCO Finland
Right side
1.6
8.3
255
1777
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
33.6
8.1
10
*
ZXA10
NOMESCO Finland
Bilateral
1.7
8.0
165
1026
S01GX02
ATC
levocabastine; ophthalmic
3.2
7.9
39
124
H02.1
ICD-10 Finland
Ectropion of eyelid
5.1
7.8
23
46
CGE10
NOMESCO Finland
Keratectomy
45.3
7.7
9
*
S01GX05
ATC
lodoxamide; ophthalmic
12.0
7.6
13
11
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
12.0
7.6
13
11
H18.4
ICD-10 Finland
Corneal degeneration
12.0
7.6
13
11
H11.8
ICD-10 Finland
Other specified disorders of conjunctiva
80.7
7.4
8
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
80.7
7.4
8
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
7.2
299
2226
H17.8
ICD-10 Finland
Other corneal scars and opacities
30.2
7.2
9
*
CFA20
NOMESCO Finland
Biopsy of conjunctiva
30.2
7.2
9
*
H17.1
ICD-10 Finland
Other central corneal opacity
20.2
7.1
10
5
H01.0
ICD-10 Finland
Blepharitis
2.7
6.8
44
168
S01GX09
ATC
olopatadine; ophthalmic
6.2
6.8
17
28
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.7
178
1189
ZXA05
NOMESCO Finland
Left side
1.5
6.4
235
1692
H25.8
ICD-10 Finland
Other senile cataract
1.8
6.3
108
633
3401
FHL
Removal of local modification or taking a specimen in the operating room
+∞
6.3
6
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.1
6.0
64
314

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
937
8617
1.80
8.16
18.3
19.7
4.0
4.0
mmol/l
1.34
906
8386
965
8971
1.92
7.88
23.1
24.2
134.0
134.3
g/l
0.26
949
8811
963
8967
1.87
7.52
22.9
24.0
91.1
91.6
fl
2.69
947
8808
963
8968
1.87
7.50
22.8
23.9
30.3
30.5
pg
2.20
947
8807
963
8969
1.87
7.48
22.9
24.0
4.4
4.4
e12/l
0.22
930
8692
940
8693
1.76
7.47
18.4
19.5
83.3
83.5
umol/l
0.06
940
8688
963
8971
1.87
7.45
23.0
24.1
6.8
6.8
e9/l
0.21
928
8694
962
8966
1.85
7.32
23.0
24.0
241.4
240.8
e9/l
0.10
930
8713
930
8598
1.70
7.10
18.2
19.5
139.6
139.6
mmol/l
0.50
902
8375
478
3899
1.41
6.95
5.3
5.8
57.5
58.3
%
0.61
443
3645
479
3912
1.41
6.90
5.6
6.2
8.6
8.9
%
1.25
447
3653
477
3893
1.41
6.90
5.4
5.9
2.9
2.9
%
0.08
445
3621
484
3970
1.41
6.75
5.6
6.0
26.8
26.4
%
0.33
442
3689
880
8054
1.57
6.67
5.1
4.9
5.9
6.1
mmol/l
2.69
780
7236
932
8679
1.65
6.20
10.8
10.9
25.8
25.7
u/l
0.06
891
8319
667
5835
1.39
6.05
4.4
4.4
—
—
—
0
0
886
8165
1.54
6.04
16.2
16.5
23.5
27.3
mg/l
2.50
712
6614
458
3787
1.37
5.81
5.5
5.8
0.7
0.7
%
0.19
426
3529
689
6114
1.37
5.38
4.8
4.1
12.7
13.7
mm/h
1.05
632
5591
402
3287
1.36
5.35
2.2
2.2
—
—
—
0
0
889
8249
1.50
5.34
5.5
5.2
2.7
2.6
mmol/l
2.57
801
7488
490
4133
1.35
5.31
5.1
5.6
0.0
0.0
e9/l
0.60
423
3564
504
4272
1.35
5.28
5.3
5.8
0.2
0.2
e9/l
0.05
440
3746
486
4116
1.34
5.04
5.1
5.6
0.6
0.6
e9/l
0.48
420
3538
355
2879
1.35
4.89
5.1
5.7
—
—
—
0
0
493
4202
1.33
4.82
5.3
5.7
1.8
1.9
e9/l
0.17
431
3691
861
7988
1.43
4.71
4.9
4.6
1.5
1.4
mmol/l
4.16
777
7245
435
3667
1.32
4.50
9.8
10.2
0.0
0.0
e9/l
0.32
365
3024
422
3560
1.31
4.29
4.6
4.0
61.9
58.1
ng/l
0.07
318
2735
897
8422
1.44
4.25
15.1
15.9
—
—
—
0
0
864
8059
1.40
4.25
4.9
4.6
4.6
4.5
mmol/l
3.86
786
7375
671
6041
1.31
4.11
4.0
4.2
—
—
—
0
0
90
583
1.59
4.04
2.5
3.0
—
—
—
0
0
832
7741
1.36
3.92
6.0
6.3
40.5
40.7
mmol/mol
0.28
745
7096
472
4083
1.28
3.84
3.6
3.8
0.0
0.0
estimate
0.50
102
751
796
7373
1.33
3.76
4.5
4.4
2.0
2.0
mu/l
0.06
709
6615
630
5665
1.28
3.69
4.7
4.6
33.9
2480.5
e6/l
1.89
12
103
659
5962
1.28
3.66
3.6
3.6
15.0
15.0
pmol/l
0.10
578
5319
83
542
1.58
3.62
3.7
3.2
4.1
4.1
e9/l
0.06
62
414
77
500
1.58
3.45
1.3
1.3
—
—
—
0
0
462
4026
1.26
3.42
5.2
5.1
0.0
0.0
estimate
0.00
104
779
771
7150
1.29
3.34
16.8
17.7
38.0
39.1
%
1.55
489
4624
326
2729
1.28
3.34
4.9
4.1
—
—
—
0
0
266
2174
1.30
3.27
3.5
3.6
—
—
—
0
0
175
1351
1.35
3.20
1.5
1.5
2.5
2.7
g/l
0.44
98
809
188
1486
1.32
2.93
1.3
1.2
4.1
1.6
u/ml
0.50
47
404
458
4037
1.24
2.93
3.5
3.8
0.0
0.0
estimate
0.00
101
779
13
46
2.85
2.92
11.3
17.0
—
—
—
0
0
83
1173
0.68
2.85
7.1
7.8
1.3
1.1
mmol/l
0.23
73
904
21
96
2.21
2.84
1.2
1.2
—
—
—
0
0
819
7711
1.28
2.81
4.4
4.1
1.2
1.3
mmol/l
2.25
730
6958
38
631
0.59
2.70
8.4
9.2
1.1
1.4
%
1.01
38
625
713
6622
1.24
2.66
18.7
20.1
13.7
13.9
%
1.09
699
6476
576
5236
1.22
2.64
4.3
5.1
6.8
6.8
mmol/l
0.45
543
4939
103
756
1.40
2.58
4.9
4.0
1.2
1.2
mmol/l
0.10
92
651
74
511
1.48
2.57
1.2
1.2
—
—
—
0
0
59
871
0.66
2.54
2.1
2.3
0.2
0.2
g/l
0.07
49
815
710
6618
1.22
2.44
7.3
7.7
82.2
80.4
u/l
0.30
665
6190
262
2212
1.25
2.41
1.7
1.6
1.3
1.3
mmol/l
0.92
212
1803
39
621
0.61
2.37
8.4
9.6
94.6
94.0
%
0.35
39
616
40
627
0.62
2.28
8.1
9.4
0.6
0.7
%
0.50
40
621
530
4821
1.20
2.28
7.6
8.9
4.1
4.2
e9/l
0.69
470
4207
69
484
1.46
2.24
3.3
3.9
—
—
—
0
0
357
3139
1.21
2.19
3.8
3.9
56.1
139.7
e6/l
1.85
260
2328
104
790
1.35
2.15
2.0
2.2
128.1
135.8
ug/g
0.09
83
628
125
980
1.31
2.09
1.4
1.3
924.8
445.2
titre
1.10
33
217
208
1741
1.24
2.06
1.7
1.6
1.9
1.4
mg/l
0.46
161
1369
434
3912
1.19
1.99
10.5
11.1
1.3
1.3
inr
0.04
143
1083
309
2704
1.20
1.97
2.4
2.2
190.8
276.2
u/l
1.18
288
2535
34
212
1.62
1.90
1.2
1.1
—
—
—
0
0
34
212
1.62
1.90
1.8
2.0
7.8
12.8
mg/l
2.93
29
193
51
351
1.48
1.86
1.4
1.2
—
—
—
0
0
290
2539
1.20
1.82
3.1
3.1
—
—
—
0
0
36
231
1.58
1.81
1.3
1.5
327.7
276.2
ug/g
0.59
19
144
216
1843
1.22
1.78
2.6
2.9
554.4
559.1
mosm/kgh2o
0.11
187
1573
447
4071
1.17
1.75
6.1
5.4
5.9
3.0
ug/l
0.57
393
3606
314
2778
1.19
1.75
3.4
3.5
103.9
101.8
e6/l
0.01
249
2190
143
1171
1.26
1.73
1.3
1.2
—
—
—
0
0
66
487
1.38
1.68
2.6
2.4
—
—
—
0
0
33
214
1.56
1.61
3.7
4.0
36.3
29.9
mg/l
0.36
22
136
264
2325
1.18
1.54
2.6
2.8
12415.6
7558.5
umol/l
0.48
219
1991
411
3751
1.16
1.52
2.1
2.1
94.5
93.4
pmol/l
0.13
213
2001
147
1228
1.23
1.50
1.4
1.3
42.9
37.8
iu/ml
0.14
39
384
14
72
1.96
1.49
1.1
1.1
0.1
1.1
u/ml
—
6
20
40
276
1.47
1.49
3.9
4.9
—
—
—
0
0
99
793
1.27
1.46
1.5
1.6
—
—
—
0
0
51
689
0.73
1.43
5.2
5.3
—
—
—
0
0
282
2513
1.17
1.42
3.3
3.3
0.3
0.5
e6/l
3.17
221
1943
173
1481
1.20
1.39
3.2
3.1
2.1
1.5
e6/l
0.30
108
884
36
249
1.46
1.34
1.6
1.6
—
—
—
0
0
91
731
1.27
1.33
3.6
3.9
—
—
—
0
0
111
922
1.23
1.22
1.2
1.3
—
—
—
0
0
193
1691
1.17
1.20
2.7
3.1
2.5
2.5
mmol/l
0.26
167
1482
258
2315
1.15
1.18
3.8
3.2
0.8
0.8
ug/l
0.13
186
1647
194
1707
1.17
1.15
4.5
4.5
—
—
—
0
0
98
814
1.22
1.10
1.6
1.5
—
—
—
0
0
5
21
2.39
1.09
2.0
1.4
—
—
—
0
0
416
3873
1.12
1.06
3.9
5.0
35.0
34.8
g/l
0.31
370
3595
14
82
1.72
1.05
1.2
1.2
—
—
—
0
0
200
1778
1.15
1.04
4.3
3.9
921.1
340.0
ng/l
0.79
174
1487
28
391
0.71
1.01
3.8
4.6
—
—
—
0
0
83
686
1.23
0.99
4.9
4.3
0.0
0.1
%
0.92
24
210
7
36
1.95
0.97
1.3
1.5
—
—
—
0
0
7
36
1.95
0.97
1.3
1.5
—
—
—
0
0
10
54
1.86
0.96
1.0
1.0
—
—
—
0
0
85
709
1.22
0.94
1.6
1.5
—
—
—
0
0
83
691
1.22
0.93
2.3
2.7
—
—
—
0
0
320
2956
1.12
0.92
3.3
3.1
1380.8
1694.4
ng/l
1.15
278
2575
6
28
2.15
0.91
1.5
2.2
3.7
8.9
nmol/l
—
6
22
18
118
1.53
0.91
1.1
1.1
—
—
—
0
0
154
1358
1.16
0.91
2.4
2.5
2.3
2.3
g/l
0.50
138
1259
15
94
1.60
0.91
1.3
1.3
—
0.5
nmol/l
—
0
7
63
768
0.81
0.88
3.1
3.4
—
—
—
0
0
13
79
1.65
0.88
2.0
2.1
4.5
2.5
u/field
—
6
28
22
153
1.45
0.86
3.3
2.8
5.5
4.6
e9/l
0.61
22
153
14
88
1.60
0.84
1.3
1.3
—
—
—
0
0
6
31
1.94
0.84
1.7
2.2
—
—
—
0
0
19
129
1.48
0.83
1.4
1.4
118.4
99.3
u/ml
—
8
21
79
664
1.21
0.83
2.5
2.2
12.1
12.4
nmol/l
0.11
68
583
18
121
1.50
0.83
1.1
1.1
—
—
—
0
0
261
2398
1.12
0.83
2.1
2.2
2.9
3.1
mg/l
0.47
225
2043
67
804
0.82
0.82
6.8
8.6
—
—
—
0
0
26
189
1.39
0.81
2.6
2.8
—
—
—
0
0
86
731
1.19
0.81
4.8
4.2
0.8
1.0
%
0.28
25
233
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
26
0.00
0.78
0.0
1.1
—
1.6
—
0
19
225
2057
1.12
0.78
6.2
6.8
—
—
—
0
0
0
27
0.00
0.77
0.0
1.4
—
22.2
—
0
19
17
245
0.69
0.77
1.8
2.5
55.1
120.2
ug/min
—
7
151
260
2402
1.11
0.75
3.3
3.3
—
—
—
0
0
9
54
1.67
0.74
1.6
1.2
—
—
—
0
0
76
645
1.19
0.74
5.1
4.4
0.1
0.6
%
0.57
18
187
131
1162
1.15
0.74
1.3
1.3
4.0
13.5
u/ml
2.91
36
409
7
38
1.85
0.73
1.3
1.6
—
—
—
0
0
315
2943
1.10
0.73
3.1
3.4
2.3
2.3
mmol/l
0.04
261
2569
144
1288
1.14
0.72
2.6
2.6
22.2
23.1
%
0.30
116
1098
44
354
1.25
0.71
2.5
3.2
0.2
0.3
g/l
0.80
19
134
116
1023
1.15
0.71
1.6
1.8
—
—
—
0
0
7
40
1.75
0.71
2.1
2.5
770.9
1650.6
u/ml
—
7
40
15
217
0.69
0.71
1.3
2.7
25.6
32.6
umol/l
—
10
180
22
160
1.38
0.70
3.4
3.1
62.9
59.8
%
0.44
22
160
32
248
1.30
0.69
1.1
1.1
—
—
—
0
0
10
61
1.65
0.68
1.3
1.1
—
—
—
0
0
16
227
0.70
0.68
1.1
1.2
—
440.0
—
0
6
244
2259
1.10
0.68
1.5
1.6
21.2
19.9
nmol/l
0.57
209
1913
484
4623
1.09
0.68
5.5
6.3
11.3
12.2
umol/l
1.29
452
4392
28
214
1.32
0.67
1.8
2.3
130.2
129.0
g/l
0.07
21
157
51
421
1.22
0.67
1.1
1.2
—
—
—
0
0
14
94
1.50
0.67
2.3
1.8
3344.9
1276.7
u/l
—
5
29
5
95
0.52
0.66
1.2
1.2
—
—
—
0
0
13
86
1.52
0.66
1.2
1.3
—
—
nmol/l
—
0
0
53
442
1.21
0.64
1.5
1.4
—
—
—
0
0
199
2159
0.90
0.63
2.4
2.5
—
—
—
0
0
204
1880
1.11
0.62
3.5
3.7
—
—
—
0
0
76
657
1.17
0.62
4.0
4.1
0.6
0.5
%
0.05
14
172
95
837
1.15
0.61
2.7
2.9
66.6
66.3
g/l
0.16
87
765
112
999
1.14
0.60
1.6
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
8
53
1.51
0.58
1.1
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
2.0
—
—
—
0
0
36
441
0.81
0.58
3.2
3.8
23.9
24.0
mmol/l
0.06
28
401
21
158
1.34
0.57
1.8
1.5
—
—
—
0
0
360
3421
1.08
0.56
2.8
2.8
146.9
153.7
ug/l
0.20
320
3114
20
150
1.34
0.56
1.5
1.3
—
—
—
0
0
26
203
1.29
0.56
1.8
2.7
16.9
15.9
%
0.43
14
107
61
525
1.17
0.54
2.9
3.0
0.1
0.3
e6/l
2.36
61
516
392
4101
0.93
0.54
4.3
4.3
—
—
—
0
0
468
4497
1.07
0.53
6.2
7.2
1.2
1.2
mmol/l
1.07
399
3792
15
108
1.39
0.53
1.4
1.3
—
—
—
0
0
30
370
0.81
0.52
3.2
3.5
40.9
3969.1
u/ml
0.81
25
311
263
2790
0.92
0.52
2.9
3.3
282.9
295.7
mg/l
0.02
157
1860
9
134
0.67
0.52
1.6
1.3
—
—
—
0
0
11
157
0.70
0.51
2.7
1.5
—
—
—
0
0
11
75
1.47
0.50
1.0
1.2
—
—
—
0
0
41
343
1.20
0.50
1.8
1.5
—
—
—
0
0
145
1331
1.10
0.50
1.8
2.2
—
—
—
0
0
124
1130
1.11
0.49
1.5
1.3
—
—
—
0
0
207
1934
1.09
0.49
2.6
2.7
3.6
4.7
e6/l
1.19
183
1706
280
2650
1.08
0.48
3.4
3.3
—
—
—
0
0
26
208
1.26
0.48
3.3
5.1
2.7
2.6
mmol/l
0.08
17
142
243
2288
1.08
0.48
3.8
4.1
0.0
0.0
estimate
0.24
98
739
18
137
1.32
0.47
2.9
2.7
—
—
—
0
0
20
155
1.30
0.47
1.3
2.0
1.6
1.7
mmol/l
0.21
20
150
286
2713
1.07
0.47
2.6
2.6
60.2
56.9
u/l
0.33
255
2523
289
2743
1.07
0.46
4.1
4.4
—
—
—
0
0
5
82
0.61
0.46
1.2
1.2
—
—
—
0
0
204
2172
0.92
0.45
1.4
1.3
—
—
—
0
0
272
2864
0.93
0.44
2.8
3.2
7.1
7.5
mmol/l
1.12
223
2374
88
794
1.12
0.43
1.5
1.4
—
—
—
0
0
43
369
1.17
0.42
1.7
1.9
—
—
—
0
0
104
949
1.11
0.42
1.8
1.6
—
—
—
0
0
19
149
1.28
0.42
5.8
4.2
2.0
1.2
%
0.41
13
126
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
173.3
—
0
10
15
114
1.32
0.41
1.1
1.1
—
—
—
0
0
79
875
0.89
0.40
6.6
7.2
9.8
10.8
mmol/l
0.58
72
830
39
453
0.86
0.40
1.2
1.4
—
—
—
0
0
103
943
1.10
0.39
3.6
3.6
—
7.4
—
0
5
81
732
1.12
0.39
2.1
2.1
362.3
367.7
nmol/l
0.07
72
672
137
1473
0.92
0.39
2.6
3.3
0.8
0.8
mmol/l
0.75
127
1376
14
181
0.77
0.38
1.1
1.2
4.0
3.8
mmol/l
0.48
14
166
23
188
1.23
0.37
1.0
1.1
—
—
—
0
0
9
68
1.33
0.37
1.1
1.1
—
—
—
0
0
9
68
1.33
0.37
1.2
1.2
—
—
—
0
0
158
1480
1.08
0.37
2.5
2.5
12.2
12.7
umol/l
0.39
141
1370
9
69
1.31
0.37
1.1
1.1
—
—
—
0
0
8
115
0.69
0.37
1.3
1.4
—
—
—
0
0
18
224
0.80
0.37
1.6
1.6
13725.7
17920.8
e6/l
0.16
12
165
11
81
1.36
0.36
1.5
1.4
—
—
—
0
0
9
71
1.27
0.36
2.4
2.5
—
—
—
0
0
284
2961
0.94
0.35
3.6
4.0
4.0
8.6
mg/mmol
4.27
173
1943
6
44
1.37
0.34
1.0
1.1
—
—
—
0
0
25
209
1.20
0.34
2.6
4.0
—
—
—
0
0
15
118
1.28
0.33
1.0
1.2
—
—
—
0
0
24
201
1.20
0.32
1.9
2.2
—
—
—
0
0
11
83
1.33
0.32
1.1
1.5
—
—
—
0
0
16
128
1.25
0.32
1.0
1.3
75.2
207.2
miu/ml
—
7
49
48
537
0.89
0.31
6.7
8.0
24.8
24.7
mmol/l
0.08
48
532
7
54
1.30
0.30
2.0
2.0
—
—
—
0
0
7
56
1.25
0.29
1.4
1.8
—
—
—
0
0
7
56
1.25
0.29
1.4
1.6
—
—
—
0
0
8
106
0.75
0.29
2.4
1.7
—
—
—
0
0
8
106
0.75
0.29
2.4
1.7
—
—
—
0
0
8
106
0.75
0.29
2.4
1.7
—
—
—
0
0
8
106
0.75
0.29
2.4
1.7
—
—
—
0
0
7
57
1.23
0.29
1.1
1.1
—
—
—
0
0
194
1852
1.06
0.28
1.8
1.8
1028.5
1168.9
nmol/l
1.72
147
1420
43
480
0.89
0.28
1.4
1.8
1.4
1.5
g/l
0.83
35
422
37
328
1.13
0.27
2.4
3.7
30.8
77.8
mg/l
1.73
32
268
50
452
1.11
0.27
2.4
2.8
—
—
—
0
0
8
66
1.21
0.26
1.0
1.3
—
—
—
0
0
22
187
1.18
0.26
1.3
1.2
—
—
—
0
0
5
75
0.67
0.26
1.6
1.1
—
—
—
0
0
33
292
1.13
0.25
2.4
2.5
38.0
37.3
g/l
0.27
26
253
22
255
0.86
0.24
3.6
3.7
—
—
—
0
0
12
148
0.81
0.24
1.5
1.3
—
—
—
0
0
10
78
1.28
0.24
1.4
1.7
—
—
—
0
0
6
85
0.70
0.24
1.0
1.2
—
—
—
0
0
93
990
0.93
0.23
2.2
2.8
7.4
9.8
umol/l
1.36
70
870
50
546
0.91
0.23
6.6
10.8
—
—
—
0
0
188
1806
1.05
0.23
3.8
4.2
1.0
1.0
kg/l
0.38
39
267
26
228
1.14
0.23
2.3
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
7.0
—
0
5
0
10
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
12
145
0.83
0.21
1.9
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
11
134
0.82
0.20
1.1
1.3
19918.8
72902.5
e6/l
—
6
77
0
14
0.00
0.20
0.0
1.4
—
34.4
—
0
14
42
384
1.10
0.20
2.6
3.2
4.5
4.4
pmol/l
0.34
37
335
6
50
1.20
0.19
1.0
1.3
136.5
145.4
nmol/l
—
6
50
272
2646
1.04
0.19
3.7
4.2
7.4
7.4
ph
0.82
61
504
17
146
1.17
0.19
1.6
1.7
2.7
5.2
iu/l
—
6
42
41
447
0.91
0.19
2.0
2.0
1.2
1.8
ug/l
0.29
35
395
6
52
1.15
0.19
2.3
2.7
1573.3
1805.7
ml
—
6
44
7
58
1.21
0.18
1.0
1.1
—
—
—
0
0
36
329
1.10
0.18
2.4
3.7
21.9
98.8
mg/l
1.23
31
271
16
138
1.16
0.17
2.5
2.8
—
—
—
0
0
57
609
0.93
0.17
1.5
1.4
—
—
—
0
0
8
69
1.16
0.16
1.0
1.3
—
35.3
—
0
6
20
224
0.89
0.15
3.2
3.1
0.9
0.8
nmol/l
0.50
13
173
19
213
0.89
0.15
2.3
2.8
—
—
—
0
0
9
83
1.09
0.14
1.0
1.1
—
—
—
0
0
11
93
1.18
0.14
1.8
1.3
42.5
52.5
mu/l
0.17
11
81
14
160
0.87
0.14
1.5
1.7
—
—
—
0
0
9
108
0.83
0.13
1.1
1.1
—
—
—
0
0
15
133
1.13
0.12
2.5
2.4
—
—
—
0
0
75
719
1.05
0.12
1.7
1.5
—
—
—
0
0
13
114
1.14
0.12
3.2
2.5
—
—
—
0
0
44
465
0.94
0.11
3.6
3.8
—
—
—
0
0
128
1246
1.03
0.10
5.0
5.6
1.0
1.0
mmol/l
0.40
115
1148
17
154
1.11
0.10
5.1
3.4
—
—
—
0
0
85
879
0.96
0.10
4.0
2.5
8.5
7.0
ug/l
0.31
70
773
29
309
0.94
0.09
1.7
1.4
—
—
—
0
0
279
2830
0.98
0.09
2.6
2.6
—
—
—
0
0
6
54
1.11
0.09
1.5
1.6
—
—
—
0
0
6
56
1.07
0.08
1.2
1.1
—
—
—
0
0
115
1179
0.97
0.08
3.0
2.4
1.6
1.8
%
1.38
100
1051
40
382
1.05
0.07
1.4
1.3
—
—
—
0
0
15
137
1.10
0.07
1.5
1.4
—
—
—
0
0
8
90
0.89
0.06
3.3
3.4
—
—
—
0
0
42
404
1.04
0.06
1.0
1.1
153.2
133.4
iu/ml
0.10
13
157
15
162
0.92
0.06
1.3
1.4
54.2
64.2
mmol/l
—
10
135
86
880
0.98
0.06
2.4
2.6
66.4
68.4
e9/l
0.18
67
702
10
90
1.11
0.05
1.2
1.4
—
—
—
0
0
414
4111
1.01
0.05
5.2
6.3
1.2
1.2
mmol/l
0.31
376
3727
10
110
0.91
0.05
10.2
5.2
—
—
—
0
0
19
179
1.06
0.05
1.7
1.6
—
—
—
0
0
20
189
1.06
0.04
1.2
1.2
—
—
—
0
0
133
1312
1.02
0.04
23.0
28.0
1.6
1.4
inr
0.58
23
173
88
896
0.98
0.04
4.1
4.5
—
—
—
0
0
17
160
1.06
0.04
1.6
1.2
—
—
—
0
0
16
151
1.06
0.03
2.1
1.7
293.3
278.7
mu/l
0.11
16
140
26
270
0.96
0.03
8.0
12.0
—
—
—
0
0
26
251
1.04
0.02
1.8
3.8
—
—
—
0
0
64
651
0.98
0.02
3.5
3.6
5.0
5.1
kpa
0.51
58
605
204
2028
1.01
0.02
1.8
1.8
425.3
22944403.8
pmol/l
1.76
157
1678
10
107
0.93
0.02
3.2
2.4
—
—
—
0
0
67
679
0.99
0.01
2.6
3.9
97.1
96.8
ng/l
0.01
56
594
24
233
1.03
0.01
1.1
1.2
—
—
—
0
0
92
912
1.01
0.01
3.7
3.6
1.5
2.0
mmol/l
0.55
76
718
11
114
0.96
0.00
3.2
2.1
—
—
—
0
0
14
136
1.03
0.00
1.4
1.2
274.6
268.2
u/ml
—
9
76
12
119
1.01
0.00
1.2
1.3
—
—
—
0
0
12
119
1.01
0.00
1.2
1.3
—
—
—
0
0
12
119
1.01
0.00
1.2
1.3
—
—
—
0
0
13
129
1.01
0.00
1.1
1.4
—
—
—
0
0
64
642
1.00
0.00
3.5
3.6
7.4
7.4
ph
—
7
86
11
113
0.97
0.00
1.2
1.3
—
—
—
0
0
12
117
1.03
0.00
1.2
1.3
—
—
—
0
0
13
133
0.98
0.00
1.1
1.6
—
—
—
0
0
23
233
0.99
0.00
1.5
1.6
—
—
—
0
0
28
277
1.01
0.00
1.2
1.2
—
—
—
0
0
10
95
1.05
0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
7
76
0.92
0.00
2.3
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
102
1020
1.00
0.00
3.2
4.2
37.4
27.7
ug/l
0.14
82
858
5
53
0.94
0.00
1.2
1.1
45.1
43.7
mg/l
—
5
46
6
61
0.98
0.00
2.0
2.7
—
—
—
0
0
5
52
0.96
0.00
1.6
1.5
1.0
1.0
g/l
—
5
52
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
0.00
1.2
1.1
326.0
271.7
mg/l
—
5
46

Mortality – FinRegistry

↥

Association

Association between endpoint H7_PTERYGIUM and mortality.

Females

Parameter HR [95% CI] p-value
H7_PTERYGIUM 0.801 [0.69, 0.92] 0.002
Birth year 0.993 [0.98, 1.0] 0.096

During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 2393 females with H7_PTERYGIUM died.

Males

Parameter HR [95% CI] p-value
H7_PTERYGIUM 0.781 [0.7, 0.87] < 0.001
Birth year 0.993 [0.98, 1.0] 0.137

During the follow-up period (1.1.1998 — 31.12.2019), 750 out of 3406 males with H7_PTERYGIUM died.

Mortality risk

Mortality risk for people of age

years, who have H7_PTERYGIUM.

N-year risk Females Males
1 0.067% 0.156%
5 0.458% 1.033%
10 1.213% 2.673%
15 2.145% 5.331%
20 3.639% 9.071%

Relationships between endpoints

↥

Index endpoint: H7_PTERYGIUM – Pterygium

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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