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Pyogenic granuloma

DOID EFO PheWeb R13 (public) Endpoint Browser PheWeb

L12_PYOGENGRANUL

Hodgkins lymphoma: Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L98.0
  • Hospital discharge: ICD-9 — 6861
  • Hospital discharge: ICD-8 — 68610
  • Cause of death: ICD-10 — L98.0
  • Cause of death: ICD-9 — 6861
  • Cause of death: ICD-8 — 68610

2 out of 7 registries used, show all original rules.

725

4. Check minimum number of events

None

725

5. Include endpoints

None

725

6. Filter based on genotype QC (FinnGen only)

700

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L98
Name in latin
Granuloma pyogenicum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4805 2431 2340
Only index persons 4301 2212 2089
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 42.38 42.80 41.78
Only index persons 43.15 42.91 43.40

-FinnGen-

Key figures

All Female Male
Number of individuals 700 396 304
Unadjusted period prevalence (%) 0.14 0.14 0.14
Median age at first event (years) 53.04 47.30 60.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
725
Matched controls
7250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.0
ICD-10 Finland
Pyogenic granuloma
4503599627370496.0
307.7
698
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
44.1
94.9
57
14
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.7
80.0
145
262
ZXC10
NOMESCO Finland
Use of laser
8.9
39.0
50
60
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.4
34.5
46
58
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
11.1
28.8
31
29
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
24.3
26.3
37
16
ZXC50
NOMESCO Finland
Cryotherapy
6.3
22.7
39
65
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
9.1
22.5
28
32
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.5
19.8
72
221
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
6.9
19.3
30
45
ZXC07
NOMESCO Finland
Carbon dioxide laser
102.7
18.6
20
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
5.6
17.8
34
63
XQ848
NOMESCO Finland
Dermatological photography
5.1
16.8
36
74
6861A
ICD-9 Finland
Other local infections of skin and subcutaneous tissue, Pyogenic granuloma
+∞
16.7
16
*
D18.0
ICD-10 Finland
Haemangioma, any site
4.9
15.3
34
72
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
4.4
13.2
33
77
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
12.7
41
116
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.9
12.1
59
216
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.6
11.9
71
289
68610
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Granuloma pyogenicum
+∞
11.5
11
*
J01DB01
ATC
cefalexin; oral
1.9
10.4
598
5136
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.3
10.1
81
377
S18
ICPC
Laceration/cut
1.7
10.0
328
2406
S04
ICPC
Lump/swelling localized
2.2
10.0
94
468
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
9.9
88
428
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
26.4
9.8
13
5
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
30.5
9.4
12
*
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
22.0
9.4
13
6
E0000UV, ,
ATC
1.6
8.9
291
2119
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.8
8.7
155
959
C08CA01
ATC
amlodipine; oral
1.6
8.5
240
1679
QCA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of upper limb
27.9
8.5
11
*
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
4.8
8.1
18
38
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
22.3
8.0
11
5
A46
ICD-10 Finland
Erysipelas
2.0
8.0
95
515
TQW99
NOMESCO Finland
Other minor procedure on skin
2.9
7.9
38
138
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.7
7.9
18
39
L89
ICD-10 Finland
Decubitus ulcer and pressure area
13.2
7.9
13
10
D02AX
ATC
Other emollients and protectives
3.3
7.7
28
86
A28
ICPC
Limited function/disability NOS
1.8
7.7
117
687
XQ845
NOMESCO Finland
Dermatoscopy
4.6
7.7
18
40
NHQ40
NOMESCO Finland
Amputation of toe
9.0
7.6
15
17
S21
ICPC
Skin texture symptom/complaint
1.8
7.5
111
647
E000001, ,
ATC
1.7
7.5
140
875
E000003, ,
ATC
2.8
7.4
37
138
ZZR00
NOMESCO Finland
Flap of skin
4.2
7.3
19
46
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
5.9
7.3
19
33
S97
ICPC
Chronic ulcer skin
2.6
7.2
41
163
L04AA06
ATC
mycophenolic acid; systemic
4.6
7.2
17
38
ZZA00
NOMESCO Finland
Split skin graft
3.6
7.2
23
65
J01FF01
ATC
clindamycin; systemic
1.6
7.2
178
1199
L30.3
ICD-10 Finland
Infective dermatitis
3.1
7.2
30
101
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
20.2
7.1
10
5
J01CF05
ATC
flucloxacillin; systemic
2.2
7.1
58
272
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.4
7.0
47
202
ZXE00
NOMESCO Finland
One hour or less
1.5
6.9
260
1928
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
3.7
6.8
21
58
Z2221
NOMESCO Finland
Medical doctor
1.6
6.7
186
1283
DHB10
NOMESCO Finland
Excision of lesion of internal nose
12.4
6.6
11
9
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
10.1
6.5
12
12
S29
ICPC
Skin symptom/complaint other
1.7
6.5
137
883
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
4.0
6.5
18
46
D07AC13
ATC
mometasone; topical
1.6
6.4
188
1314
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.4
244
1810
ZXA05
NOMESCO Finland
Left side
1.6
6.3
151
1004
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.3
6.3
45
200
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
2.2
6.1
48
223
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.0
142
941

TimeCodeWAS

↥

TimeCodeWAS is a tool for exploring time-dependent associations between an endpoint and health codes (diagnoses, lab tests, procedures, etc.).

The TimeCodeWAS analysis is done in three steps:

  1. Build a matched case-control set for this endpoint. Each case is matched to 5–10 controls on sex and year of birth, and controls must be at risk at the same age as the case's age of onset. TimeCodeWAS allows for controls to be reused.
  2. Count cases and controls. For each health code, and for each time window: tally the counts into a 2×2 table. To be eligible in a time window, a case or control must have data coverage for at least 50% of that time window.
  3. Perform association tests. If all cells of the 2×2 table have N≥10, then a χ² test is performed, otherwise a Fisher's exact test is done. The corresponding p-value and confidence interval are reported below, along with the standard odds ratio when a χ² test is done, or Fisher's MLE odds ratio otherwise.

TimeCodeWAS currently uses the same default set of time windows for all the endpoints. Please reach out to us if you have suggestions for better time windows for some endpoints. The default time windows are: TimeCodeWAS time windows

Sort & Filter
Sort
Odds Ratio
among windows:
Filter
Code & OMOP
Cases and controls with code
in
Odds Ratio
in
OMOP Concept
Code (OMOP Vocabulary) [OMOP Concept ID]
OMOP Concept Class / OMOP Domain
Odds Ratio
TimeCodeWAS O.R. time legend
Cases and controls with code
TimeCodeWAS Cases and Controls percentages time legend
Outpatient Visit
OP (Visit) [9202]
Visit / Visit
3.1e-01 6.3e-01 1.0e+00 5.5e+00 1.7e+00 8.7e-01 6.1e-01
77.13%/71.12% 64.20%/48.79% 23.44%/10.06% 51.85%/0.43% 36.75%/9.64% 68.84%/48.17% 85.39%/76.09%
cefalexin; oral
J01DB01 (ATC) [21602870]
ATC 5th / Drug
4.2e-01 1.3e+00 2.7e+00 4.3e+00 2.1e+00 7.3e-01 6.3e-01
36.22%/27.13% 24.57%/8.46% 12.64%/0.97% 4.83%/0.07% 7.83%/1.04% 16.32%/8.58% 39.08%/25.50%
Plastic And Reconstructive Surgery
24 (Medicare Specialty) [38004467]
Physician Specialty / Provider
5.0e-01 1.4e+00 3.1e+00 1.0e+50 4.2e+00 2.2e+00 1.0e+00
3.84%/2.35% 3.41%/0.90% 2.98%/0.14% 6.11%/0.00% 5.41%/0.09% 6.82%/0.78% 5.81%/2.19%
Clinical & Laboratory Dermatological Immunology Physician
207NI0002X (NUCC) [38003841]
Physician Specialty / Provider
7.8e-01 1.5e+00 2.7e+00 — 3.9e+00 2.5e+00 1.1e+00
12.64%/6.24% 10.37%/2.51% 6.39%/0.44% —/— 19.52%/0.47% 22.70%/2.42% 16.55%/6.10%
Case Management Agency
251B00000X (NUCC) [38004193]
Visit / Visit
1.0e-01 2.9e-01 9.4e-01 3.7e+00 7.5e-01 2.4e-01 1.0e-01
66.76%/64.45% 64.49%/57.68% 44.03%/23.58% 37.50%/1.44% 40.31%/24.13% 65.43%/59.77% 78.87%/77.08%
Laboratory Visit
OMOP4822461 (Visit) [32036]
Visit / Visit
9.3e-04 2.7e-01 7.4e-01 3.7e+00 7.4e-01 1.6e-01 1.0e-01
42.76%/42.73% 45.88%/39.40% 21.45%/11.56% 17.76%/0.53% 21.51%/11.53% 44.81%/40.92% 61.09%/58.66%
Inpatient Hospital
21 (CMS Place of Service) [8717]
Visit / Visit
1.5e-01 8.9e-01 1.3e+00 3.5e+00 1.4e+00 7.1e-01 4.4e-01
33.52%/30.28% 20.17%/9.40% 4.26%/1.24% 2.70%/0.09% 5.13%/1.27% 14.84%/7.85% 31.34%/22.65%
Other and unspecified skin changes
R23.8 (ICD10) [45573020]
ICD10 code / Condition
4.0e-01 2.1e+00 3.4e+00 — — 7.1e-01 4.0e-02
2.70%/1.82% 5.11%/0.64% 3.41%/0.11% —/— —/— 1.78%/0.89% 3.35%/3.22%
Ophthalmology
18 (Medicare Specialty) [38004463]
Physician Specialty / Provider
2.9e-01 3.0e-01 7.0e-01 3.4e+00 1.0e+00 4.3e-01 2.0e-01
17.47%/13.62% 8.10%/6.10% 1.70%/0.85% 2.41%/0.09% 2.85%/1.06% 9.35%/6.29% 17.96%/15.15%

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
381
2358
2.30
26.40
2.4
2.0
—
—
—
0
0
132
684
2.14
12.76
2.3
1.5
—
—
—
0
0
263
1830
1.69
9.79
7.4
6.1
—
—
—
0
0
136
790
1.89
9.36
1.5
1.3
—
—
—
0
0
340
2557
1.62
9.16
6.8
4.9
35.63
36.12
g/l
0.86
326
2415
400
3245
1.52
7.00
7.7
6.3
1.82
1.94
e9/l
1.45
360
2869
224
1607
1.57
6.90
2.8
2.3
2.86
2.80
mg/l
0.14
205
1383
375
3023
1.50
6.62
7.7
6.3
27.15
28.09
%
0.89
353
2888
389
3161
1.50
6.60
7.6
6.2
0.57
0.57
e9/l
0.02
338
2716
390
3172
1.50
6.58
7.7
6.2
0.04
0.04
e9/l
0.58
340
2730
366
2950
1.49
6.38
7.9
6.3
8.61
8.77
%
0.51
340
2787
430
3589
1.49
6.23
6.0
4.9
6.80
6.57
mmol/l
1.10
401
3352
382
3116
1.48
6.21
4.2
3.1
100.95
106.95
ug/l
0.34
366
2920
364
2943
1.48
6.17
7.8
6.2
2.68
2.79
%
0.41
339
2772
363
2938
1.47
6.10
8.0
6.3
0.66
0.67
%
0.06
339
2758
139
913
1.65
6.09
2.7
2.4
2.41
2.33
g/l
0.71
134
843
368
2987
1.47
6.09
7.5
6.2
58.17
57.20
%
0.83
351
2868
398
3281
1.47
6.08
7.9
6.6
0.17
0.19
e9/l
1.15
356
2868
241
1800
1.51
6.03
2.3
2.1
128.15
237.57
u/l
2.21
231
1716
70
380
1.93
5.86
4.1
3.1
162.28
208.12
ng/l
0.47
62
343
661
6119
1.91
5.84
20.4
14.3
24.55
23.18
mg/l
0.45
560
4984
203
1473
1.53
5.79
3.0
2.7
343.97
343.15
umol/l
0.04
183
1315
223
1652
1.51
5.76
3.3
3.2
1825.79
1172.30
ng/l
1.07
186
1391
334
2680
1.46
5.76
21.6
12.9
1.32
1.22
inr
2.31
291
2218
326
2606
1.46
5.72
2.1
2.1
92.59
95.36
pmol/l
0.44
168
1404
423
3553
1.46
5.70
10.5
9.6
4.14
4.11
e9/l
0.09
372
3075
584
5243
1.59
5.63
26.3
17.8
13.68
13.53
%
1.84
577
5192
357
2912
1.45
5.58
3.6
2.8
—
—
estimate
—
0
0
266
2062
1.46
5.41
7.6
6.1
—
—
—
0
0
339
2753
1.43
5.35
2.8
2.5
75.61
75.31
nmol/l
0.07
314
2505
98
608
1.71
5.31
5.6
4.1
7.37
7.38
ph
0.87
62
341
103
650
1.68
5.24
6.3
8.1
5.05
5.07
kpa
0.05
97
625
524
4622
1.48
5.24
9.7
7.7
80.44
78.51
u/l
0.37
496
4387
474
4103
1.45
5.21
5.5
4.4
1047.50
831.23
e6/l
—
6
65
102
643
1.68
5.21
6.2
8.3
1.25
0.92
mmol/l
0.31
87
537
103
651
1.68
5.21
6.2
8.1
12.61
12.33
kpa
0.14
97
629
342
2793
1.42
5.18
14.3
10.8
0.00
0.00
e9/l
0.34
283
2267
120
792
1.62
5.12
7.3
7.4
104.32
104.49
mmol/l
0.13
120
792
130
878
1.59
5.04
2.6
1.8
—
—
—
0
0
147
1022
1.55
5.03
3.2
3.5
0.81
0.82
mmol/l
0.31
136
977
489
4274
1.44
4.98
5.6
4.3
—
3.32
—
0
8
360
2981
1.41
4.97
8.8
7.1
1.21
1.21
mmol/l
0.94
321
2594
121
807
1.60
4.94
7.7
5.5
1.08
1.04
mmol/l
0.84
114
753
610
5582
1.59
4.88
6.8
5.9
39.61
38.80
mmol/mol
1.32
582
5265
24
91
2.69
4.69
4.0
3.5
3.71
4.23
e9/l
0.66
24
91
166
1201
1.50
4.69
3.7
2.8
529.29
545.46
mosm/kgh2o
0.45
149
1049
679
6406
1.94
4.68
13.9
11.0
27.28
26.43
u/l
0.63
662
6244
192
1443
1.45
4.45
5.2
4.7
—
—
—
0
0
50
267
1.94
4.43
2.1
1.8
—
—
—
0
0
99
646
1.62
4.42
6.5
8.3
7.40
7.42
ph
0.39
47
368
119
816
1.55
4.30
1.3
1.2
—
—
—
0
0
91
587
1.63
4.26
5.8
4.1
2.15
1.76
mmol/l
0.48
77
495
393
3359
1.37
4.22
4.5
3.7
0.00
4.96
estimate
0.80
82
706
208
1605
1.42
4.14
5.3
4.1
—
—
—
0
0
229
1802
1.40
4.06
6.2
3.9
7.40
7.40
ph
0.13
166
1265
700
6712
2.24
4.03
30.9
21.8
90.40
90.65
fl
0.80
694
6648
700
6712
2.24
4.03
31.2
21.9
253.21
251.05
e9/l
0.37
691
6589
700
6714
2.24
3.99
30.9
21.8
30.06
30.24
pg
2.10
694
6649
700
6714
2.24
3.99
31.1
21.8
4.49
4.52
e12/l
1.23
688
6581
700
6714
2.24
3.99
31.5
22.3
40.20
40.57
%
1.26
694
6645
322
2683
1.36
3.99
8.1
6.4
1.20
1.21
mmol/l
1.85
301
2496
193
1479
1.42
3.97
4.3
3.6
1.02
1.02
kg/l
0.10
135
978
388
3330
1.36
3.95
4.5
3.7
0.00
0.00
estimate
0.50
82
698
700
6716
2.23
3.95
31.1
21.9
6.84
6.74
e9/l
0.46
688
6575
14
43
3.30
3.92
2.6
3.4
687.14
1054.91
mg
0.66
14
43
700
6718
2.22
3.91
31.2
22.0
133.98
135.92
g/l
2.87
694
6653
266
2161
1.36
3.84
3.0
3.1
31.23
32.18
u/l
0.22
253
2054
240
1919
1.37
3.82
3.5
2.6
53.15
62.88
u/l
1.87
220
1802
169
1273
1.43
3.82
1.7
1.7
—
—
—
0
0
321
2687
1.35
3.81
4.0
3.3
6.19
6.21
ph
0.06
190
1507
652
6139
1.62
3.73
23.7
16.4
139.66
139.66
mmol/l
0.01
641
6016
97
656
1.55
3.73
2.6
2.9
2.03
1.82
%
0.68
90
591
229
1827
1.37
3.67
3.8
2.9
0.00
0.06
—
5
34
391
3386
1.34
3.63
4.6
3.7
0.04
0.46
estimate
0.46
80
670
87
581
1.57
3.54
6.5
8.6
93.03
95.50
%
0.90
81
566
125
904
1.46
3.49
1.7
1.7
1118.36
1174.61
nmol/l
0.28
100
709
41
223
1.89
3.48
1.4
1.2
—
—
—
0
0
651
6148
1.58
3.43
24.0
16.5
3.95
3.96
mmol/l
0.03
638
6009
72
463
1.62
3.43
5.6
4.0
87.37
80.84
ng/l
0.28
63
413
80
528
1.58
3.42
8.8
9.0
—
—
—
0
0
75
490
1.59
3.35
1.6
1.6
1079.62
982.43
mu/l
0.51
64
419
177
1375
1.38
3.31
3.2
2.5
6.48
6.38
e6/l
0.02
163
1243
148
1117
1.41
3.28
4.6
3.7
251.11
400.06
ng/l
0.50
118
809
610
5698
1.44
3.26
5.8
5.1
1.89
1.87
mu/l
0.16
580
5295
92
636
1.51
3.21
2.5
2.0
387.77
386.90
nmol/l
0.02
87
594
77
512
1.56
3.20
4.5
3.8
4.42
4.60
kpa
0.47
72
497
15
55
2.76
3.17
2.1
3.0
—
—
—
0
0
225
1835
1.33
3.03
4.4
3.4
64.84
51.01
mg/l
0.41
162
1186
244
2017
1.32
2.98
3.9
3.2
2.36
2.35
mmol/l
0.28
228
1837
664
6332
1.58
2.96
18.2
12.8
—
—
—
0
0
25
121
2.10
2.96
4.6
3.1
56.68
58.17
%
0.28
25
121
250
2078
1.31
2.93
4.2
3.4
7.49
8.06
mmol/l
1.18
220
1775
228
1876
1.31
2.86
5.2
4.1
12.31
8.32
mg/mmol
0.72
163
1175
525
4825
1.32
2.80
4.7
4.2
14.50
14.68
pmol/l
1.07
490
4433
673
6452
1.60
2.75
26.3
18.1
78.79
75.57
umol/l
1.76
668
6381
221
1821
1.31
2.73
3.9
2.9
—
—
—
0
0
635
6019
1.44
2.71
5.7
5.3
2.59
2.73
mmol/l
3.66
597
5643
361
3171
1.28
2.70
7.1
6.2
11.77
11.35
umol/l
0.34
342
3023
124
942
1.38
2.63
1.7
1.9
—
—
—
0
0
44
268
1.68
2.63
2.2
2.2
—
—
—
0
0
39
230
1.74
2.61
1.7
1.9
1.04
2.86
ug/l
0.72
34
202
7
15
4.70
2.60
2.4
1.6
0.59
0.60
mmol/l
—
7
15
144
1125
1.35
2.56
3.5
2.8
2.45
2.44
mmol/l
0.14
129
1008
54
352
1.58
2.48
2.8
2.9
—
—
—
0
0
206
1703
1.29
2.45
1.7
1.6
20.20
20.15
nmol/l
0.02
184
1444
72
503
1.48
2.42
2.7
2.7
82.36
71.34
e9/l
0.98
51
377
97
717
1.41
2.42
3.4
2.6
10.01
7.64
umol/l
0.38
88
627
626
5945
1.39
2.40
5.2
4.7
4.46
4.62
mmol/l
3.75
592
5592
29
161
1.83
2.38
4.1
6.0
1.39
1.25
mmol/l
0.26
23
141
72
506
1.47
2.36
3.8
4.9
0.04
0.08
%
0.33
23
135
293
2540
1.26
2.35
4.4
3.5
0.00
0.03
estimate
1.95
70
590
225
1891
1.28
2.34
4.0
3.1
0.00
0.06
estimate
0.77
68
570
9
28
3.24
2.31
1.3
1.4
126.89
148.26
nmol/l
—
9
28
271
2334
1.26
2.29
5.6
3.9
88.47
93.84
e6/l
0.05
206
1626
235
1994
1.26
2.25
1.8
1.6
—
—
—
0
0
29
167
1.77
2.14
1.2
1.2
—
—
—
0
0
97
733
1.37
2.14
1.6
1.4
—
—
—
0
0
620
5908
1.34
2.07
5.0
4.7
1.41
1.45
mmol/l
1.76
583
5530
133
1060
1.31
2.06
3.7
2.9
0.91
0.89
e6/l
0.03
75
549
24
132
1.85
2.06
4.5
2.8
—
—
—
0
0
465
4283
1.24
2.04
3.4
3.3
48.13
44.87
u/l
0.33
441
4074
31
185
1.71
2.04
1.0
1.2
—
—
—
0
0
235
2022
1.24
1.95
4.6
3.2
33.75
87.77
e6/l
0.92
191
1535
6
16
3.77
1.94
4.2
2.9
—
—
—
0
0
150
1227
1.28
1.91
1.9
1.7
439.00
26978508.56
pmol/l
1.20
125
1049
59
417
1.45
1.91
2.2
2.4
4.08
8.41
ug/l
1.95
51
366
73
537
1.40
1.90
3.9
4.8
0.90
0.82
%
0.14
25
168
125
1003
1.30
1.85
4.3
3.1
3.14
2.29
e6/l
0.47
65
492
236
2042
1.23
1.84
2.6
2.3
—
—
—
0
0
181
1522
1.25
1.83
2.3
2.1
—
—
—
0
0
24
138
1.76
1.81
5.1
4.7
—
—
—
0
0
203
1735
1.24
1.77
4.2
3.1
0.61
0.41
e6/l
0.48
160
1254
281
2490
1.21
1.71
3.1
2.9
—
—
—
0
0
604
5770
1.28
1.71
5.5
4.7
5.97
5.89
mmol/l
0.75
572
5330
14
68
2.08
1.71
2.8
2.7
0.89
1.17
g/24h
—
7
50
108
864
1.29
1.64
1.6
1.6
—
—
—
0
0
21
120
1.77
1.63
1.7
1.9
—
—
—
0
0
13
63
2.08
1.60
3.4
5.9
11.88
11.33
%
0.15
13
63
70
528
1.36
1.60
3.8
5.2
0.05
0.10
%
0.26
20
132
139
1152
1.26
1.60
1.4
1.3
17.87
29.37
iu/ml
1.23
42
349
31
200
1.57
1.56
1.3
1.2
—
—
—
0
0
211
1833
1.21
1.56
5.2
5.3
2.03
2.38
ug/l
0.48
192
1660
16
85
1.90
1.56
3.1
3.3
1.06
1.40
%
0.22
16
77
88
691
1.31
1.54
1.5
1.4
—
—
—
0
0
54
394
1.40
1.51
3.9
3.6
4.38
4.61
pmol/l
1.17
44
354
9
37
2.45
1.48
1.3
1.5
184.76
185.50
pmol/l
—
9
37
67
509
1.35
1.48
3.7
4.6
0.60
0.56
%
0.09
24
151
9
38
2.39
1.46
2.6
3.1
0.56
0.92
index
—
9
38
7
28
2.51
1.45
1.0
1.9
53.04
92.88
ng/l
—
7
28
14
73
1.94
1.44
1.1
1.4
26.29
28.74
ng/l
0.12
14
73
5
122
0.41
1.38
1.4
1.1
—
—
—
0
0
9
42
2.16
1.34
1.0
1.2
—
—
—
0
0
15
83
1.82
1.32
1.4
1.4
—
—
—
0
0
15
83
1.82
1.32
1.4
1.4
—
—
—
0
0
15
83
1.82
1.32
1.4
1.4
—
—
—
0
0
15
83
1.82
1.32
1.4
1.4
—
—
—
0
0
47
345
1.39
1.30
1.3
1.2
—
—
—
0
0
34
235
1.47
1.29
1.6
1.4
8.36
8.48
u/l
0.02
28
186
8
34
2.37
1.29
1.5
1.5
5.14
6.25
mmol/l
—
8
34
108
895
1.24
1.26
3.0
2.6
212.60
114.53
ug/g
1.03
91
711
35
245
1.45
1.26
2.0
1.8
22.80
9.05
iu/ml
—
5
47
18
108
1.68
1.23
4.8
2.7
9.30
8.37
pmol/l
0.14
18
108
58
445
1.33
1.23
4.9
3.6
1.23
1.23
mmol/l
0.43
48
383
105
870
1.24
1.23
1.3
1.4
500.00
532.09
titre
0.09
28
182
70
552
1.30
1.22
3.1
2.5
11.33
12.94
nmol/l
0.85
64
503
5
19
2.64
1.22
1.0
1.9
34.60
25.79
%
—
5
19
26
173
1.52
1.19
4.7
4.7
24.96
85.80
mg/l
1.11
21
150
161
1400
1.19
1.17
1.8
1.7
1.05
1.25
mg/l
0.72
127
1083
251
2266
1.16
1.16
4.3
3.5
26.91
61.01
ng/l
0.70
179
1522
126
1072
1.21
1.15
1.3
1.3
15.00
11.37
u/ml
0.21
50
402
16
96
1.68
1.11
1.9
1.3
—
—
—
0
0
175
1542
1.18
1.09
5.3
3.8
88.48
90.63
%
0.51
170
1515
7
32
2.20
1.08
1.0
2.3
—
—
—
0
0
11
59
1.88
1.08
1.8
1.7
—
—
—
0
0
5
22
2.28
1.03
2.6
1.6
—
—
—
0
0
205
1839
1.16
1.02
4.2
3.7
0.00
0.01
estimate
0.99
79
659
30
214
1.42
1.01
1.6
1.5
—
—
—
0
0
20
132
1.53
0.98
1.1
1.1
—
—
—
0
0
20
132
1.53
0.98
1.1
1.1
—
—
—
0
0
0
30
0.00
0.97
0.0
1.3
—
129.79
—
0
21
581
5616
1.17
0.96
4.5
4.0
1.28
1.27
mmol/l
0.07
543
5216
82
682
1.23
0.96
1.4
1.4
—
—
—
0
0
38
286
1.35
0.95
1.6
1.6
108.92
62.64
ug/l
0.68
33
246
90
757
1.22
0.94
3.4
3.1
4.10
5.52
e9/l
1.00
79
681
177
1581
1.16
0.93
1.4
1.3
0.66
1.87
u/ml
2.54
50
451
60
483
1.26
0.93
1.1
1.3
102.50
155.03
u/ml
0.59
22
189
29
211
1.39
0.89
1.5
1.5
1.21
1.27
mm
0.48
22
154
25
177
1.43
0.89
1.2
1.1
—
—
—
0
0
6
29
2.08
0.89
1.8
1.7
—
—
—
0
0
9
153
0.58
0.89
1.7
1.3
—
—
—
0
0
15
96
1.57
0.85
1.1
1.1
—
—
—
0
0
68
563
1.23
0.84
1.4
1.5
—
—
—
0
0
24
171
1.42
0.84
1.3
1.4
303.65
282.63
ug/g
0.31
14
100
20
284
0.70
0.83
1.4
1.3
169.90
245.72
miu/ml
—
10
138
12
74
1.63
0.78
2.8
1.5
31.25
33.14
pg
0.82
12
74
13
82
1.60
0.78
1.4
3.2
—
—
—
0
0
50
404
1.26
0.78
1.1
1.2
—
—
—
0
0
63
524
1.22
0.76
4.0
3.5
—
—
—
0
0
29
218
1.34
0.76
1.7
1.6
—
—
—
0
0
10
59
1.70
0.76
1.9
1.4
—
—
—
0
0
18
255
0.70
0.75
2.1
1.8
—
—
—
0
0
9
54
1.67
0.74
2.0
1.3
—
—
—
0
0
9
55
1.64
0.73
2.8
2.9
13.11
13.50
index
—
9
38
44
354
1.26
0.72
1.7
1.4
20.17
22.12
iu/l
0.15
37
299
41
328
1.26
0.71
1.0
1.1
—
—
—
0
0
67
568
1.20
0.68
1.8
2.1
0.00
0.03
estimate
0.50
11
119
50
412
1.23
0.68
6.2
3.9
7.40
7.42
ph
1.20
45
340
14
95
1.48
0.64
1.4
1.2
—
—
—
0
0
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
44
530
0.82
0.61
4.4
4.2
7.28
7.35
ph
0.55
36
388
29
227
1.29
0.61
2.9
2.7
—
—
—
0
0
0
20
0.00
0.60
0.0
2.1
—
14.81
—
0
20
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
3.9
—
36.96
—
0
16
8
52
1.54
0.59
1.1
1.2
—
—
—
0
0
59
503
1.19
0.59
1.4
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
60
513
1.18
0.58
1.3
1.2
—
—
—
0
0
8
54
1.49
0.57
1.5
2.0
41.14
40.87
%
—
8
54
21
160
1.32
0.54
4.7
4.3
0.98
2.79
ratio
2.11
12
91
9
61
1.48
0.54
2.9
3.5
2.04
3.46
nmol/l
—
9
61
9
64
1.41
0.51
1.7
2.7
25.94
24.07
nmol/l
—
9
58
19
145
1.32
0.49
1.9
1.5
15278.00
14967.41
e6/l
0.02
14
107
29
235
1.24
0.49
1.8
1.6
40.27
7.45
u/ml
—
6
56
42
355
1.19
0.48
2.4
2.4
6312.16
5900.76
u/l
0.03
19
157
64
562
1.15
0.47
1.7
1.7
3.43
3.43
mmol/l
0.01
38
403
8
117
0.68
0.46
1.1
1.0
—
—
—
0
0
10
69
1.46
0.44
2.2
2.8
1.20
1.19
mmol/l
—
10
69
7
51
1.38
0.44
1.0
1.3
—
—
—
0
0
5
31
1.62
0.43
6.2
2.7
605.00
631.65
u/ml
—
5
31
30
249
1.21
0.42
1.2
1.1
0.88
0.87
g/l
0.02
30
249
263
2507
1.08
0.42
2.0
1.9
1.35
1.35
mmol/l
0.03
223
2156
10
70
1.43
0.42
2.2
2.8
102.60
105.71
mmol/l
—
10
70
10
70
1.43
0.42
2.2
2.8
3.98
4.03
mmol/l
—
10
70
0
15
0.00
0.41
0.0
1.3
—
8.65
—
0
15
0
15
0.00
0.41
0.0
1.1
—
0.67
—
0
8
17
132
1.29
0.40
1.8
2.4
392.80
73.19
ug/min
0.61
11
74
5
34
1.47
0.40
7.4
1.9
27.60
29.62
umol/l
—
5
29
0
18
0.00
0.40
0.0
1.4
—
12.13
—
0
12
8
61
1.31
0.39
2.0
3.0
63.38
57.71
%
—
8
55
5
35
1.43
0.39
2.2
3.3
15.12
16.45
%
—
5
35
0
19
0.00
0.39
0.0
1.4
—
26.68
—
0
19
22
179
1.24
0.37
2.0
2.0
213.05
221.40
pmol/l
0.08
22
166
9
70
1.29
0.36
1.0
1.1
—
—
—
0
0
20
163
1.23
0.34
2.7
2.3
14.25
11.80
mg/l
0.49
20
151
19
154
1.24
0.34
1.9
2.2
—
—
—
0
0
17
136
1.26
0.34
1.9
1.6
0.70
0.95
nmol/l
1.07
17
114
27
229
1.19
0.32
1.1
1.1
0.66
0.66
ratio
—
6
23
7
97
0.72
0.31
2.9
6.0
290.14
379.90
umol/l
—
7
87
7
55
1.28
0.30
1.0
1.2
—
—
—
0
0
21
176
1.20
0.29
1.2
1.1
2.17
3.34
u/ml
0.32
16
91
7
57
1.23
0.29
2.0
1.2
—
—
—
0
0
28
242
1.16
0.28
1.1
1.1
1.51
1.53
g/l
0.19
28
242
10
77
1.30
0.26
1.1
1.2
—
—
—
0
0
60
550
1.10
0.26
3.0
4.5
8.83
31.08
ug/l
0.86
46
459
9
72
1.25
0.25
1.0
1.3
—
—
—
0
0
22
189
1.17
0.24
1.0
1.1
1.18
9.04
eliau/ml
—
6
25
27
306
0.88
0.23
1.4
1.6
0.29
0.29
mg/l
—
10
142
5
39
1.28
0.23
3.2
1.5
79.80
76.31
umol/l
—
5
39
5
39
1.28
0.23
1.4
3.1
10.68
7.32
mmol/l
—
5
39
21
181
1.17
0.22
1.6
2.0
3.43
4.41
iu/l
—
10
74
7
92
0.76
0.22
1.6
1.2
—
—
—
0
0
63
584
1.09
0.22
2.7
2.4
30.63
33.48
u/l
0.38
51
487
5
40
1.25
0.22
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
2.82
—
0
11
0
10
0.00
0.21
0.0
1.0
—
5.83
—
0
10
0
10
0.00
0.21
0.0
1.1
—
0.02
—
0
10
0
10
0.00
0.21
0.0
1.6
—
7700.80
—
0
10
148
1418
1.05
0.21
1.8
1.5
2.51
2.32
g/l
0.34
87
911
0
12
0.00
0.21
0.0
4.8
—
8.83
—
0
12
0
12
0.00
0.21
0.0
2.4
—
43.00
—
0
12
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
47
433
1.09
0.19
2.4
2.4
40.21
17.45
au/ml
—
7
35
15
127
1.18
0.19
1.5
1.5
0.22
0.35
nmol/l
1.05
15
103
115
1098
1.06
0.19
3.3
3.1
0.69
0.74
ug/l
0.40
72
695
10
81
1.24
0.19
1.3
1.3
43.72
73.69
mu/l
—
10
75
53
493
1.08
0.18
2.9
2.3
5.97
6.14
ph
0.75
38
322
7
60
1.17
0.18
1.4
2.5
—
—
—
0
0
5
67
0.74
0.17
1.0
1.4
—
—
nmol/l
—
0
0
5
69
0.72
0.17
1.4
2.9
—
—
—
0
0
9
78
1.16
0.15
1.3
1.4
321.78
367.70
pmol/l
—
9
70
17
190
0.89
0.13
1.4
1.2
—
—
—
0
0
22
200
1.10
0.12
2.2
1.5
1.19
1.22
g/l
0.22
22
189
10
116
0.86
0.12
1.8
1.6
—
—
—
0
0
10
115
0.87
0.10
1.1
1.2
—
—
—
0
0
5
45
1.11
0.10
1.2
1.0
—
—
—
0
0
5
62
0.81
0.08
1.0
1.2
—
—
—
0
0
5
64
0.78
0.08
1.0
1.3
—
—
—
0
0
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
14
127
1.10
0.08
1.0
1.1
14.86
14.32
au/ml
—
5
41
8
74
1.08
0.07
2.6
2.4
—
—
—
0
0
21
196
1.07
0.07
2.2
1.5
0.23
0.24
g/l
0.17
21
188
28
265
1.06
0.07
1.3
1.4
—
—
—
0
0
24
226
1.06
0.06
2.0
4.5
321.21
312.46
mg/l
0.02
14
107
35
365
0.96
0.06
1.4
1.6
—
—
—
0
0
13
141
0.92
0.05
1.7
1.4
—
—
—
0
0
10
110
0.91
0.05
1.3
1.4
31.62
22.02
u/l
—
10
90
33
343
0.96
0.05
1.5
1.6
—
—
—
0
0
35
340
1.03
0.03
1.6
1.7
—
—
—
0
0
11
102
1.08
0.03
1.2
1.1
—
20.75
—
0
21
28
271
1.03
0.02
1.1
1.1
—
—
—
0
0
17
162
1.05
0.02
1.2
1.4
489.71
449.64
mg/l
0.12
17
154
30
292
1.03
0.02
5.8
4.2
—
—
—
0
0
32
312
1.03
0.02
1.7
2.2
0.00
2.46
estimate
—
8
102
12
113
1.06
0.02
1.4
1.9
—
—
—
0
0
12
114
1.05
0.00
2.7
2.0
3.99
5.08
mmol/24h
0.65
12
102
10
104
0.96
0.00
3.3
4.0
2955.56
2649.02
u/ml
—
10
99
19
194
0.98
0.00
15.1
9.3
—
—
—
0
0
37
365
1.01
0.00
1.5
1.7
—
—
—
0
0
85
845
1.01
0.00
1.6
1.6
—
—
—
0
0
14
142
0.99
0.00
1.1
1.3
3.38
3.69
mmol/l
0.83
14
133
37
367
1.01
0.00
1.5
1.7
—
—
—
0
0
11
109
1.01
0.00
1.1
1.0
6.76
2.27
eliau/ml
—
5
42
37
369
1.00
0.00
1.5
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
49.78
—
0
9
5
57
0.88
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
2.08
—
0
9
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
1.5
1.5
—
—
—
0
0
5
49
1.02
-0.00
2.2
1.2
98.00
106.12
pmol/l
—
5
49
5
51
0.98
-0.00
1.0
1.2
—
—
—
0
0
13
130
1.00
-0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.03
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
582.44
—
0
5
7
74
0.95
-0.00
2.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
189.80
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
66.80
—
0
5
9
95
0.95
-0.00
1.3
1.3
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.1
—
7.47
—
0
14
0
5
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
402.00
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PYOGENGRANUL and mortality.

Females

Parameter HR [95% CI] p-value
L12_PYOGENGRANUL 1.543 [1.27, 1.88] < 0.001
Birth year 0.995 [0.99, 1.0] 0.298

During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 1977 females with L12_PYOGENGRANUL died.

Males

Parameter HR [95% CI] p-value
L12_PYOGENGRANUL 1.421 [1.16, 1.73] < 0.001
Birth year 0.989 [0.98, 1.0] 0.039

During the follow-up period (1.1.1998 — 31.12.2019), 274 out of 1844 males with L12_PYOGENGRANUL died.

Mortality risk

Mortality risk for people of age

years, who have L12_PYOGENGRANUL.

N-year risk Females Males
1 0.179% 0.302%
5 1.04% 1.5%
10 2.355% 4.318%
15 4.488% 8.409%
20 7.648% 14.355%

Relationships between endpoints

↥

Index endpoint: L12_PYOGENGRANUL – Pyogenic granuloma

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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