Hodgkins lymphoma: Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
634 |
4. Check minimum number of eventsNone |
634 |
5. Include endpointsNone |
634 |
6. Filter based on genotype QC (FinnGen only) |
634 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L98
- Name in latin
- Granuloma pyogenicum
Similar endpoints
↥List of similar endpoints to
Pyogenic granuloma
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4805 | 2431 | 2340 |
| Only index persons | 4301 | 2212 | 2089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.38 | 42.80 | 41.78 |
| Only index persons | 43.15 | 42.91 | 43.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 634 | 355 | 279 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | 52.24 | 46.38 | 59.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 548
- Matched controls
- 5479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.0
ICD-10 Finland
Pyogenic granuloma
4503599627370496.0
323.0
524
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.0
40.7
108
185
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
427.3
40.6
40
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
52.7
25.5
30
6
ZXC10
NOMESCO Finland
Use of laser
13.6
25.3
44
35
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
4.9
16.1
53
116
6861A
ICD-9 Finland
Other local infections of skin and subcutaneous tissue, Pyogenic granuloma
+∞
15.7
15
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
17.1
14.9
23
14
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
7.8
14.1
32
43
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.6
12.9
33
53
ZXC07
NOMESCO Finland
Carbon dioxide laser
71.5
12.6
14
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.5
11.5
54
165
ZXC50
NOMESCO Finland
Cryotherapy
6.8
11.4
28
43
J01DB01
ATC
cefalexin; oral
2.1
11.1
447
3719
S18
ICPC
Laceration/cut
1.8
9.9
220
1468
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
56.0
9.7
11
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
9.3
9.6
19
21
68610
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Granuloma pyogenicum
+∞
9.4
9
*
D18.0
ICD-10 Finland
Haemangioma, any site
6.1
8.8
23
39
XQ848
NOMESCO Finland
Dermatological photography
6.3
8.7
22
36
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
28.0
8.5
11
*
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
20.4
8.5
12
6
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.0
8.2
47
166
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
4.9
8.0
25
53
ZXA00
NOMESCO Finland
Right side
1.9
8.0
135
809
ZZA00
NOMESCO Finland
Split skin graft
5.4
7.8
22
42
QCA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of upper limb
45.6
7.7
9
*
E000003
ATC
NA
3.5
7.7
34
101
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
6.8
7.6
18
27
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
18.7
7.6
11
6
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
16.0
7.2
11
7
A46
ICD-10 Finland
Erysipelas
2.3
7.2
66
306
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.8
7.1
22
47
TQW99
NOMESCO Finland
Other minor procedure on skin
3.5
6.7
30
90
A28
ICPC
Limited function/disability NOS
2.1
6.4
73
375
A98
ICPC
Health maint/preventive medicine
2.5
6.3
521
4851
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
+∞
6.3
6
*
QCE99
NOMESCO Finland
Other excision or repair of lesion of skin of upper limb
27.0
6.2
8
*
S91.3
ICD-10 Finland
Open wound of other parts of foot
5.4
6.2
17
32
L89
ICD-10 Finland
Decubitus ulcer and pressure area
12.7
6.1
10
8
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.7
6.0
40
158
D07AB08
ATC
desonide; topical
2.2
6.0
63
312
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
266
1987
1.58
7.19
6.2
4.6
35.2
35.9
g/l
1.14
252
1853
103
596
1.87
7.18
6.2
5.4
1.1
1.0
mmol/l
1.18
96
551
352
2873
1.51
5.96
5.5
4.5
6.8
6.6
mmol/l
1.03
319
2638
496
4375
1.61
5.76
23.0
15.7
13.7
13.6
%
1.20
488
4298
16
41
3.98
5.74
1.3
1.8
—
—
—
0
0
171
1206
1.57
5.67
2.7
2.2
3.1
2.9
mg/l
0.31
157
1034
103
642
1.72
5.56
2.4
2.3
21.0
23.4
%
1.01
86
549
174
1252
1.54
5.23
3.3
3.1
1997.1
1237.7
ng/l
1.02
143
1050
288
2297
1.47
5.22
7.6
6.6
1.2
1.2
mmol/l
1.23
247
1943
286
2284
1.46
5.12
3.6
2.7
107.0
109.3
ug/l
0.09
273
2115
82
494
1.76
4.98
6.2
7.8
5.1
5.1
kpa
0.03
77
470
82
495
1.75
4.95
6.2
7.8
13.2
12.4
kpa
0.38
77
474
22
80
2.81
4.66
4.0
3.2
3.7
4.1
e9/l
0.43
22
80
186
1394
1.47
4.51
2.3
2.0
122.4
258.7
u/l
2.14
177
1319
62
354
1.83
4.51
4.5
3.9
84.9
79.2
ng/l
0.20
53
315
80
493
1.71
4.49
6.2
7.9
1.5
1.1
mmol/l
0.27
64
395
262
2096
1.43
4.48
7.2
5.9
1.2
1.2
mmol/l
1.37
240
1908
111
746
1.59
4.45
3.4
3.4
0.8
0.8
mmol/l
1.08
103
702
293
2398
1.41
4.38
5.8
4.0
—
—
—
0
0
22
83
2.71
4.36
5.0
3.4
56.4
56.3
%
0.00
22
83
59
340
1.81
4.17
4.2
2.9
177.7
190.5
ng/l
0.09
53
304
216
1686
1.43
4.17
2.8
3.1
32.5
32.0
u/l
0.10
202
1609
237
1883
1.41
4.13
1.9
1.9
92.6
94.4
pmol/l
0.20
118
998
75
465
1.70
4.13
2.5
1.9
378.9
380.9
nmol/l
0.03
70
426
500
4526
1.50
4.11
6.3
5.3
40.4
39.5
mmol/mol
1.36
473
4224
146
1064
1.48
4.03
1.7
1.6
—
—
—
0
0
511
4659
1.50
3.93
5.2
4.4
1.9
1.9
mu/l
0.42
483
4269
554
5142
1.61
3.91
18.0
12.8
23.9
22.7
mg/l
0.31
453
4029
56
326
1.79
3.84
1.9
1.6
—
—
—
0
0
578
5430
1.73
3.80
11.7
9.4
28.5
26.5
u/l
1.36
559
5245
196
1525
1.41
3.79
3.2
2.4
53.2
57.5
u/l
1.23
177
1419
13
39
3.38
3.78
1.5
1.4
—
—
—
0
0
159
1192
1.45
3.77
2.8
2.6
2923.5
5996.7
umol/l
0.53
142
1036
436
3876
1.40
3.72
4.3
3.7
14.4
14.7
pmol/l
1.94
405
3518
383
3335
1.37
3.69
5.1
4.2
1256.0
1862.5
e6/l
—
5
52
67
416
1.68
3.68
7.1
8.6
111.6
120.7
g/l
2.58
61
401
246
2002
1.37
3.61
2.5
2.3
76.6
75.7
nmol/l
0.17
227
1796
48
272
1.83
3.61
8.3
7.1
23.8
24.6
mmol/l
0.35
41
255
426
3785
1.38
3.56
8.6
7.0
79.5
77.9
u/l
0.25
400
3547
33
604
0.52
3.38
4.6
4.2
29.5
31.7
%
0.60
26
416
292
2461
1.35
3.35
4.0
3.4
0.0
0.0
estimate
0.00
53
481
85
576
1.55
3.29
3.3
2.5
11.0
8.2
umol/l
0.38
76
496
553
5177
1.53
3.23
20.7
14.3
139.7
139.6
mmol/l
0.05
541
5032
112
808
1.47
3.22
1.8
1.7
1145.8
1190.1
nmol/l
0.19
90
620
604
5788
1.92
3.13
26.7
18.8
133.7
136.0
g/l
3.29
596
5709
291
2471
1.33
3.10
5.7
4.6
0.0
0.0
estimate
0.50
55
487
332
2873
1.33
3.10
9.7
8.9
4.2
4.1
e9/l
0.46
297
2512
21
93
2.30
3.06
2.1
1.5
—
—
—
0
0
518
4803
1.43
3.03
19.3
13.8
39.6
40.2
%
1.00
382
3622
45
265
1.75
3.01
1.6
1.4
—
—
—
0
0
296
2528
1.32
3.00
6.6
5.8
11.9
11.1
umol/l
0.65
278
2387
56
351
1.65
2.99
2.1
3.0
65.5
66.7
g/l
0.53
56
317
130
978
1.41
2.98
1.8
1.7
449.6
20170538.8
pmol/l
1.04
109
823
64
419
1.59
2.88
5.4
4.4
2.3
1.8
mmol/l
0.40
53
328
552
5192
1.49
2.87
20.9
14.4
4.0
4.0
mmol/l
0.28
538
5031
172
1369
1.35
2.79
4.7
3.9
12.2
9.9
mg/mmol
0.30
126
864
60
390
1.59
2.79
1.5
1.5
—
—
—
0
0
291
2497
1.31
2.79
4.1
3.4
0.0
0.0
estimate
0.00
53
468
117
880
1.40
2.68
4.5
3.7
301.8
348.8
ng/l
0.10
93
641
191
1557
1.32
2.62
3.8
3.1
2.4
2.3
mmol/l
0.09
176
1367
11
38
2.93
2.59
2.6
3.3
—
—
—
0
0
81
578
1.46
2.47
35.0
20.6
1.7
1.3
inr
1.56
16
84
139
1090
1.35
2.47
1.5
1.5
20.6
20.4
nmol/l
0.05
127
926
138
1085
1.35
2.40
3.8
3.6
1.0
1.0
kg/l
0.45
17
156
24
128
1.91
2.24
1.9
1.6
—
—
—
0
0
17
80
2.16
2.20
1.5
1.6
—
—
—
0
0
21
110
1.94
2.08
1.6
1.6
—
—
—
0
0
533
5047
1.35
2.07
4.8
4.5
2.7
2.8
mmol/l
2.01
495
4665
109
850
1.34
2.00
3.3
2.8
2.4
2.4
mmol/l
0.05
96
745
176
1468
1.28
1.98
3.7
3.0
7.0
7.9
mmol/l
2.16
157
1233
21
113
1.89
1.94
1.5
1.2
—
—
—
0
0
26
152
1.74
1.86
1.5
1.5
—
—
—
0
0
50
345
1.49
1.84
4.6
3.4
1.2
1.2
mmol/l
0.27
43
300
20
108
1.88
1.83
1.6
1.6
—
—
—
0
0
24
138
1.77
1.82
1.2
1.2
—
—
—
0
0
402
3701
1.24
1.80
4.4
3.8
13.7
11.0
mm/h
2.68
378
3417
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
131
1.78
1.80
3.4
2.5
0.3
0.4
u/ml
0.92
15
69
67
496
1.39
1.72
3.6
3.0
—
—
—
0
0
14
68
2.08
1.71
1.4
1.6
—
—
—
0
0
72
541
1.37
1.69
2.0
1.8
—
—
—
0
0
11
49
2.27
1.64
1.8
1.3
—
—
—
0
0
161
1358
1.25
1.62
3.9
3.0
0.7
0.4
e6/l
0.53
131
1016
20
113
1.79
1.62
1.1
2.6
0.0
0.0
g/l
0.00
20
105
220
1920
1.22
1.62
4.1
3.5
—
—
—
0
0
21
121
1.76
1.60
1.1
2.5
0.1
0.0
g/l
0.48
21
112
50
357
1.43
1.58
2.5
2.5
56.2
70.0
ml/min/173m2
1.47
20
145
20
114
1.78
1.58
1.1
2.6
0.0
0.0
g/l
0.00
20
105
27
169
1.62
1.54
2.0
1.7
—
—
—
0
0
180
1548
1.23
1.51
4.4
4.7
2.0
2.4
ug/l
0.43
163
1386
12
58
2.09
1.50
1.4
1.7
—
—
—
0
0
70
537
1.34
1.46
1.9
1.8
—
—
—
0
0
6
22
2.74
1.43
1.7
1.9
—
—
—
0
0
520
4969
1.26
1.43
4.5
4.1
4.5
4.7
mmol/l
2.27
486
4622
17
96
1.79
1.40
2.5
2.0
15.6
16.6
%
—
9
49
375
3477
1.19
1.38
3.2
3.0
53.1
45.3
u/l
0.80
351
3282
53
393
1.38
1.38
2.9
2.3
10.7
12.9
nmol/l
1.05
48
347
38
265
1.46
1.38
1.6
1.4
—
—
—
0
0
6
23
2.62
1.37
1.7
1.9
—
—
—
0
0
100
817
1.27
1.33
1.3
1.3
19.9
30.3
iu/ml
0.71
31
263
98
802
1.26
1.29
3.1
2.8
0.8
1.0
e6/l
0.30
59
445
5
18
2.79
1.28
1.0
1.0
—
—
—
0
0
95
775
1.27
1.28
2.1
1.8
—
—
—
0
0
145
1240
1.22
1.28
3.8
4.1
22.6
21.1
%
0.52
62
559
12
62
1.95
1.28
1.6
1.6
—
—
—
0
0
131
1109
1.23
1.28
1.7
1.7
1.2
1.2
mg/l
0.03
100
847
29
195
1.51
1.26
1.7
1.5
—
—
—
0
0
515
4935
1.23
1.26
4.3
4.0
1.4
1.5
mmol/l
2.90
480
4573
24
155
1.57
1.24
2.2
2.3
—
—
—
0
0
23
147
1.59
1.24
1.2
1.1
—
—
—
0
0
87
707
1.27
1.22
2.1
2.0
29.3
29.5
s
0.11
87
686
8
37
2.18
1.21
1.0
1.6
—
—
—
0
0
8
37
2.18
1.21
1.0
1.6
—
—
—
0
0
8
37
2.18
1.21
1.0
1.6
—
—
—
0
0
198
1755
1.19
1.19
4.6
3.2
—
—
—
0
0
6
26
2.32
1.19
1.7
1.8
—
—
—
0
0
12
65
1.86
1.14
1.9
1.6
—
—
—
0
0
139
1199
1.20
1.13
3.1
2.3
—
—
—
0
0
7
31
2.27
1.10
1.9
1.5
0.9
1.0
g/l
—
7
31
505
4851
1.20
1.08
5.1
4.2
6.0
5.9
mmol/l
1.08
478
4428
22
145
1.54
1.07
1.2
1.1
—
—
—
0
0
20
129
1.57
1.06
1.1
2.4
36.7
38.3
g/l
0.60
20
112
380
3573
1.16
1.04
3.7
3.3
—
—
—
0
0
9
46
1.97
1.04
2.6
3.3
2.1
3.7
nmol/l
—
9
46
93
778
1.23
1.03
3.9
2.9
2.5
2.3
e6/l
0.09
55
423
7
34
2.07
1.03
2.0
1.7
—
—
—
0
0
39
295
1.34
0.95
4.2
3.3
4.2
4.6
pmol/l
2.10
31
265
12
196
0.60
0.93
1.8
1.6
—
—
—
0
0
21
143
1.48
0.91
2.0
2.9
—
—
—
0
0
6
29
2.08
0.89
1.0
1.3
—
—
—
0
0
91
774
1.21
0.87
1.3
1.3
20.2
11.0
u/ml
0.47
37
297
8
43
1.87
0.87
2.0
1.4
—
—
—
0
0
13
80
1.64
0.85
1.2
1.3
3.4
2.9
ug/l
0.36
13
70
150
1336
1.16
0.85
4.0
3.6
0.0
0.0
estimate
0.80
54
479
492
4751
1.16
0.82
4.1
3.7
1.3
1.3
mmol/l
0.73
459
4387
6
32
1.88
0.82
1.0
1.2
—
—
—
0
0
18
122
1.49
0.81
2.6
2.1
13.9
11.7
mg/l
0.39
18
112
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
6
33
1.83
0.79
1.3
1.6
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
1.1
—
0
9
200
1830
1.14
0.77
4.2
3.4
28.4
34.5
ng/l
0.70
141
1183
9
53
1.71
0.75
2.2
1.7
—
—
—
0
0
45
362
1.26
0.74
2.4
2.3
3.6
8.6
ug/l
2.39
39
312
7
38
1.85
0.73
4.0
1.9
—
—
—
0
0
10
60
1.68
0.72
2.2
3.0
102.6
105.4
mmol/l
—
10
60
17
117
1.47
0.72
1.4
1.2
—
—
—
0
0
12
76
1.59
0.72
1.9
1.8
—
—
—
0
0
22
160
1.39
0.71
2.6
1.7
—
—
—
0
0
5
27
1.86
0.68
1.2
2.0
—
—
—
0
0
5
27
1.86
0.68
1.2
2.0
—
—
—
0
0
7
43
1.63
0.67
1.6
1.8
—
—
—
0
0
35
280
1.26
0.62
1.7
1.6
—
—
—
0
0
491
4772
1.13
0.61
17.2
11.6
81.2
84.8
ml/min/173m2
2.36
399
3863
9
138
0.65
0.61
1.2
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
22
167
1.33
0.57
1.2
1.3
—
—
—
0
0
12
81
1.49
0.57
1.3
1.1
—
—
—
0
0
56
477
1.19
0.57
2.2
1.9
—
—
—
0
0
10
149
0.67
0.57
1.6
1.9
—
—
—
0
0
23
176
1.32
0.57
1.4
1.4
—
—
—
0
0
16
115
1.40
0.57
1.1
1.1
2.7
2.9
u/ml
0.02
11
44
16
115
1.40
0.57
1.7
2.6
392.8
58.4
ug/min
0.65
11
65
18
133
1.36
0.55
3.6
4.2
24.8
103.2
mg/l
1.01
13
109
33
267
1.25
0.55
2.2
2.4
6250.0
2881.4
u/l
0.23
14
119
44
369
1.21
0.53
1.1
1.2
113.2
161.8
iu/ml
0.41
18
146
26
205
1.28
0.53
1.4
1.4
—
—
—
0
0
26
205
1.28
0.53
1.4
1.4
—
—
—
0
0
6
39
1.54
0.53
1.0
1.2
—
—
—
0
0
15
203
0.73
0.52
1.5
1.3
213.4
247.1
miu/ml
—
7
104
17
126
1.36
0.52
8.5
4.2
3.8
3.9
mmol/l
0.34
17
115
26
206
1.27
0.51
1.4
1.4
—
—
—
0
0
26
206
1.27
0.51
1.4
1.4
—
—
—
0
0
6
40
1.50
0.51
1.0
1.2
—
—
—
0
0
129
1182
1.11
0.49
1.3
1.3
0.7
1.3
u/ml
2.35
33
330
7
50
1.40
0.45
1.6
1.7
—
—
—
0
0
5
31
1.62
0.43
1.2
1.5
5.3
6.3
mmol/l
—
5
31
8
56
1.43
0.42
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
1.2
1.9
—
—
—
0
0
36
305
1.19
0.41
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
361.2
—
0
10
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
3.5
—
—
—
0
0
0
18
0.00
0.40
0.0
3.5
—
—
—
0
0
14
106
1.33
0.39
1.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
3.5
—
215.9
—
0
19
36
308
1.18
0.38
4.6
3.6
0.7
1.8
mmol/l
0.87
29
226
10
135
0.74
0.36
1.5
1.3
—
—
—
0
0
25
209
1.20
0.34
2.3
1.9
33.9
39.3
u/l
0.77
20
188
13
100
1.31
0.33
1.8
1.5
—
—
—
0
0
14
109
1.29
0.33
1.4
1.4
934.1
1113.3
e6/l
0.05
14
88
7
54
1.30
0.30
3.6
4.1
—
—
—
0
0
13
102
1.28
0.30
1.2
1.3
—
—
—
0
0
13
102
1.28
0.30
1.2
1.3
—
—
—
0
0
18
148
1.22
0.29
1.2
1.4
1.2
1.2
g/l
0.02
18
140
26
224
1.17
0.27
1.7
1.5
—
—
—
0
0
15
123
1.22
0.25
1.1
1.4
516.3
427.1
mg/l
0.26
15
115
17
142
1.20
0.25
1.4
1.5
—
216.7
—
0
6
17
143
1.19
0.23
1.2
1.4
0.2
0.2
g/l
0.15
17
138
7
95
0.73
0.22
1.0
1.2
—
—
—
0
0
5
41
1.22
0.22
1.0
2.8
17.6
55.5
u/ml
—
5
41
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
8.1
—
0
8
0
14
0.00
0.20
0.0
1.0
—
24.2
—
0
14
6
53
1.13
0.18
1.2
1.4
315.5
333.8
pmol/l
—
6
42
10
82
1.22
0.17
1.3
1.4
31.6
24.9
u/l
—
10
66
12
101
1.19
0.16
1.5
1.8
—
—
—
0
0
8
70
1.14
0.16
1.1
1.3
—
—
—
0
0
6
76
0.79
0.15
2.2
5.1
292.0
378.2
umol/l
—
6
67
94
900
1.05
0.15
3.1
2.9
0.7
0.7
ug/l
0.23
59
581
7
87
0.80
0.14
1.1
1.3
—
—
—
0
0
13
113
1.15
0.13
2.2
1.9
166.5
224.1
pmol/l
1.83
13
104
11
95
1.16
0.11
1.6
1.5
0.2
0.4
nmol/l
1.67
11
78
31
290
1.07
0.10
1.0
1.0
—
—
—
0
0
6
55
1.09
0.09
1.5
1.2
—
—
—
0
0
129
1319
0.97
0.08
1.8
1.6
1.5
1.4
mmol/l
0.43
109
1126
12
107
1.12
0.08
1.1
1.3
3.4
3.7
mmol/l
0.51
12
98
36
379
0.95
0.08
2.4
1.8
—
—
—
0
0
7
65
1.08
0.08
2.1
1.8
13.6
13.1
%
—
7
65
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
7
83
0.84
0.07
1.0
1.2
—
3.7
—
0
36
7
83
0.84
0.07
1.0
1.2
—
1.7
—
0
28
47
453
1.04
0.06
2.4
2.3
32.8
33.8
u/l
0.09
42
381
10
111
0.90
0.06
1.1
1.3
—
—
—
0
0
82
837
0.98
0.05
1.4
1.5
—
—
—
0
0
49
503
0.97
0.04
1.9
1.6
—
—
—
0
0
69
676
1.02
0.04
1.9
1.8
1.5
1.4
%
0.13
64
599
81
823
0.98
0.03
2.6
2.2
—
—
—
0
0
20
191
1.05
0.03
1.9
1.8
—
—
—
0
0
17
178
0.95
0.02
1.9
1.7
—
—
—
0
0
54
547
0.99
0.01
10.5
6.0
—
—
—
0
0
12
115
1.04
0.00
2.3
1.6
0.8
0.9
nmol/l
0.18
12
97
21
214
0.98
0.00
1.8
1.9
—
—
—
0
0
75
753
1.00
0.00
2.3
2.0
—
—
—
0
0
46
462
1.00
0.00
3.0
4.1
8.4
35.2
ug/l
0.88
36
386
13
131
0.99
0.00
1.5
1.7
4.1
5.7
iu/l
—
5
44
15
151
0.99
0.00
1.3
1.5
—
—
—
0
0
35
349
1.00
0.00
2.6
2.3
50.5
17.6
au/ml
—
5
17
0
5
0.00
0.00
0.0
10.2
—
—
—
0
0
7
72
0.97
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
9
89
1.01
0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
97
0.93
0.00
1.0
1.3
—
46.9
—
0
6
8
79
1.01
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
57
0.88
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
65.2
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
0.00
1.3
1.1
—
19.8
—
0
21
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PYOGENGRANUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.543 [1.27, 1.88] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 1977 females with L12_PYOGENGRANUL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.421 [1.16, 1.73] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 274 out of 1844 males with L12_PYOGENGRANUL died.
Mortality risk
Mortality risk for people of age
years, who have L12_PYOGENGRANUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.179% | 0.302% |
| 5 | 1.04% | 1.5% |
| 10 | 2.355% | 4.318% |
| 15 | 4.488% | 8.409% |
| 20 | 7.648% | 14.355% |
Relationships between endpoints
↥Index endpoint: L12_PYOGENGRANUL – Pyogenic granuloma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data