Hodgkins lymphoma: Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
684 |
4. Check minimum number of eventsNone |
684 |
5. Include endpointsNone |
684 |
6. Filter based on genotype QC (FinnGen only) |
662 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L98
- Name in latin
- Granuloma pyogenicum
Similar endpoints
↥List of similar endpoints to
Pyogenic granuloma
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4805 | 2431 | 2340 |
| Only index persons | 4301 | 2212 | 2089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.38 | 42.80 | 41.78 |
| Only index persons | 43.15 | 42.91 | 43.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 662 | 371 | 291 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | 53.05 | 47.27 | 60.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 684
- Matched controls
- 6840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.0
ICD-10 Finland
Pyogenic granuloma
4503599627370496.0
307.7
657
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
43.2
86.1
52
13
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.6
76.2
139
253
ZXC10
NOMESCO Finland
Use of laser
9.0
38.7
49
58
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.8
33.3
43
52
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
29.1
26.9
36
13
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.7
20.2
67
194
ZXC50
NOMESCO Finland
Cryotherapy
5.9
19.6
36
64
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
6.9
18.0
28
42
D18.0
ICD-10 Finland
Haemangioma, any site
5.7
17.6
33
60
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
13.0
17.3
30
24
6861A
ICD-9 Finland
Other local infections of skin and subcutaneous tissue, Pyogenic granuloma
+∞
16.7
16
*
ZXC07
NOMESCO Finland
Carbon dioxide laser
92.4
16.6
18
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
5.2
14.4
30
60
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.9
13.7
41
110
XQ848
NOMESCO Finland
Dermatological photography
4.8
13.7
31
67
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.8
12.8
68
261
J01DB01
ATC
cefalexin; oral
2.1
12.0
568
4787
S18
ICPC
Laceration/cut
1.8
11.5
297
2076
68610
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Granuloma pyogenicum
+∞
11.5
11
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
4.2
11.2
30
74
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
8.8
11.1
23
27
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.5
11.0
72
306
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
10.5
85
398
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
26.4
9.8
13
5
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
26.4
9.8
13
5
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.7
9.8
53
205
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
30.5
9.4
12
*
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
37.2
9.0
11
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.9
8.6
126
735
TQW99
NOMESCO Finland
Other minor procedure on skin
3.0
8.5
37
127
QCA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of upper limb
27.9
8.5
11
*
E0000UV, ,
ATC
1.6
8.2
266
1930
E000003, ,
ATC
3.0
8.2
37
130
A46
ICD-10 Finland
Erysipelas
2.1
8.1
86
448
ZXE00
NOMESCO Finland
One hour or less
1.6
8.0
255
1841
C08CA01
ATC
amlodipine; oral
1.6
7.9
218
1517
L30.3
ICD-10 Finland
Infective dermatitis
3.3
7.9
29
90
A28
ICPC
Limited function/disability NOS
1.9
7.9
102
570
L89
ICD-10 Finland
Decubitus ulcer and pressure area
15.2
7.7
12
8
J01FF01
ATC
clindamycin; systemic
1.7
7.7
171
1123
E000001, ,
ATC
1.8
7.7
134
823
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.5
7.6
46
189
D07AC13
ATC
mometasone; topical
1.7
7.4
179
1202
S19
ICPC
Skin injury other
3.2
7.4
29
94
NHQ40
NOMESCO Finland
Amputation of toe
8.9
7.1
14
16
A02BC02
ATC
pantoprazole; systemic
1.5
7.0
414
3404
S04
ICPC
Lump/swelling localized
2.0
6.9
73
379
DHB10
NOMESCO Finland
Excision of lesion of internal nose
13.9
6.9
11
8
Z2221
NOMESCO Finland
Medical doctor
1.6
6.9
180
1229
ZZA00
NOMESCO Finland
Split skin graft
3.5
6.9
23
67
J01CF05
ATC
flucloxacillin; systemic
2.4
6.9
45
192
ZXA00
NOMESCO Finland
Right side
1.7
6.8
157
1040
B01AB05
ATC
enoxaparin; parenteral
1.6
6.7
182
1254
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
12.4
6.6
11
9
S21
ICPC
Skin texture symptom/complaint
1.9
6.6
91
519
A10BJ06
ATC
semaglutide; parenteral
2.6
6.6
36
141
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
3.7
6.5
20
55
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
5.8
6.5
17
30
D02AX
ATC
Other emollients and protectives
3.1
6.4
26
86
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.4
98
578
ZXA05
NOMESCO Finland
Left side
1.7
6.3
145
956
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
18.2
6.3
9
5
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.1
230
1701
C03CA01
ATC
furosemide; systemic
1.6
6.0
162
1110
ZZR00
NOMESCO Finland
Flap of skin
3.9
6.0
17
44
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
290
2120
1.64
8.84
6.3
4.6
35.36
35.97
g/l
1.05
275
1982
116
676
1.86
7.88
2.4
2.3
21.19
23.47
%
1.01
97
583
190
1280
1.67
7.80
2.7
2.2
3.05
2.94
mg/l
0.21
174
1097
118
718
1.78
6.93
2.3
2.2
2.42
2.36
g/l
0.32
113
658
379
3085
1.51
6.51
5.4
4.5
6.73
6.61
mmol/l
0.50
343
2840
108
654
1.77
6.43
6.4
5.2
1.10
1.05
mmol/l
1.26
101
606
314
2462
1.51
6.43
3.7
2.7
103.59
108.74
ug/l
0.24
301
2279
330
2617
1.50
6.38
7.4
5.8
27.20
28.37
%
1.09
308
2472
549
4887
1.63
5.94
22.6
15.3
14.51
14.68
%
0.34
540
4813
324
2587
1.48
5.90
7.2
5.6
57.88
56.84
%
0.80
304
2447
296
2333
1.47
5.70
22.4
13.0
1.32
1.24
inr
0.80
90
722
310
2481
1.46
5.44
7.8
6.6
1.21
1.21
mmol/l
1.21
268
2119
260
2013
1.47
5.41
2.0
1.9
92.70
94.83
pmol/l
0.26
128
1064
16
43
3.79
5.39
1.3
1.8
—
—
—
0
0
203
1496
1.51
5.39
2.2
2.0
122.51
247.02
u/l
2.07
194
1411
121
808
1.60
4.95
3.3
3.4
0.80
0.82
mmol/l
0.99
112
766
94
594
1.68
4.78
7.5
7.5
104.00
104.55
mmol/l
0.41
94
594
601
5550
1.68
4.75
18.0
12.6
23.81
22.81
mg/l
0.27
488
4349
234
1814
1.44
4.70
2.9
3.0
32.22
31.79
u/l
0.09
220
1726
315
2576
1.41
4.69
3.3
2.5
—
—
—
0
0
63
358
1.84
4.63
4.0
2.9
175.56
204.55
ng/l
0.23
55
324
282
2268
1.41
4.59
7.1
5.9
1.20
1.21
mmol/l
2.00
262
2077
181
1341
1.48
4.59
3.2
3.1
1939.33
1213.04
ng/l
1.02
149
1122
85
533
1.68
4.45
6.4
7.9
5.10
5.06
kpa
0.10
80
508
85
534
1.68
4.42
6.4
7.9
13.12
12.43
kpa
0.33
80
512
66
387
1.78
4.38
4.6
4.0
85.80
78.12
ng/l
0.31
56
346
23
89
2.64
4.35
4.0
3.5
3.63
4.22
e9/l
0.74
23
89
366
3104
1.39
4.25
10.1
8.8
4.19
4.10
e9/l
0.27
325
2705
80
501
1.68
4.21
2.6
1.9
381.08
379.52
nmol/l
0.03
75
459
269
2172
1.39
4.18
2.5
2.3
76.33
75.58
nmol/l
0.16
247
1954
60
347
1.80
4.18
2.0
1.6
—
—
—
0
0
461
4073
1.40
4.12
8.9
6.9
79.69
78.21
u/l
0.24
434
3826
23
92
2.55
4.08
4.8
3.7
55.87
56.74
%
0.13
23
92
170
1270
1.45
4.08
2.9
2.6
2721.20
5582.01
umol/l
0.53
154
1118
413
3587
1.38
4.07
5.1
4.2
1256.00
1762.20
e6/l
—
5
55
83
531
1.64
4.03
6.4
8.0
1.45
1.17
mmol/l
0.20
69
430
624
5866
1.73
4.02
11.9
9.3
28.29
26.46
u/l
1.28
605
5669
536
4875
1.46
4.00
6.1
5.2
40.22
39.35
mmol/mol
1.21
507
4552
158
1171
1.45
3.94
1.7
1.6
—
—
—
0
0
550
5045
1.46
3.76
5.1
4.4
1.90
1.86
mu/l
0.28
518
4629
120
859
1.48
3.56
1.7
1.7
1140.63
1184.06
nmol/l
0.20
95
666
315
2665
1.34
3.45
4.0
3.4
0.00
0.00
estimate
0.50
65
550
210
1671
1.37
3.44
3.8
3.1
2.35
2.35
mmol/l
0.27
194
1477
60
368
1.69
3.44
2.4
3.0
65.95
66.82
g/l
0.38
60
334
652
6245
1.94
3.42
26.6
18.5
252.59
250.42
e9/l
0.35
643
6091
652
6246
1.94
3.40
26.3
18.6
39.81
40.42
%
1.66
605
5873
124
902
1.46
3.39
3.4
2.8
2.45
2.44
mmol/l
0.34
108
791
652
6249
1.93
3.35
26.5
18.5
4.49
4.53
e12/l
1.23
639
6085
90
614
1.54
3.35
3.4
2.5
10.62
8.04
umol/l
0.38
80
528
152
1152
1.41
3.32
1.5
1.5
20.37
20.62
nmol/l
0.08
138
979
36
638
0.54
3.30
4.4
4.1
29.66
31.54
%
0.54
29
440
652
6253
1.91
3.28
26.6
18.6
133.79
136.04
g/l
3.44
644
6165
128
944
1.44
3.25
4.4
3.6
273.35
373.28
ng/l
0.27
103
683
205
1639
1.36
3.23
3.3
2.4
54.30
61.60
u/l
1.27
187
1528
313
2665
1.32
3.21
5.8
4.6
0.00
0.00
estimate
0.50
60
522
317
2704
1.32
3.21
6.8
5.7
11.79
11.09
umol/l
0.58
301
2558
465
4190
1.34
3.19
4.3
3.7
14.37
14.66
pmol/l
1.92
432
3804
22
98
2.29
3.16
2.0
1.6
—
—
—
0
0
595
5593
1.49
3.10
20.5
14.1
139.66
139.64
mmol/l
0.07
583
5435
68
447
1.58
2.99
5.6
4.3
2.28
1.82
mmol/l
0.51
58
358
13
46
2.86
2.93
1.5
1.3
—
—
—
0
0
144
1107
1.38
2.87
3.1
2.4
6.38
6.31
e6/l
0.01
132
988
313
2695
1.30
2.86
4.0
3.4
0.00
0.00
estimate
-0.00
59
504
594
5609
1.45
2.74
20.7
14.2
3.95
3.96
mmol/l
0.30
580
5434
136
1047
1.37
2.68
1.8
1.6
448.59
18778710.35
pmol/l
1.04
114
884
180
1464
1.31
2.45
4.6
3.7
12.29
9.57
mg/mmol
0.37
130
928
439
3992
1.28
2.44
4.4
3.8
13.76
11.00
mm/h
2.88
415
3694
147
1163
1.34
2.43
3.9
3.5
1.02
1.02
kg/l
0.18
18
169
11
39
2.85
2.35
2.6
3.1
—
—
—
0
0
45
285
1.62
2.35
1.6
1.4
—
—
—
0
0
170
1382
1.31
2.31
4.3
3.2
1394.38
253.55
mg/l
1.04
123
899
75
534
1.45
2.31
3.5
3.0
—
—
—
0
0
25
134
1.90
2.29
1.9
1.5
—
—
—
0
0
62
426
1.50
2.28
1.6
1.5
—
—
—
0
0
13
54
2.43
2.21
1.7
1.3
—
—
—
0
0
22
115
1.94
2.18
1.8
1.6
—
—
—
0
0
24
130
1.88
2.15
1.1
2.6
0.06
0.00
g/l
0.48
24
121
176
1458
1.28
2.06
3.8
3.0
0.66
0.44
e6/l
0.47
144
1103
55
378
1.49
2.04
4.6
3.4
1.23
1.23
mmol/l
0.14
45
329
17
83
2.07
2.02
1.5
1.6
—
—
—
0
0
100
768
1.35
2.01
2.0
2.0
29.55
29.42
s
0.09
100
746
28
165
1.73
1.94
2.0
2.4
—
—
—
0
0
22
121
1.85
1.90
1.0
2.7
0.00
0.00
g/l
-0.00
22
113
22
122
1.83
1.86
1.0
2.7
0.00
0.00
g/l
-0.00
22
113
191
1619
1.25
1.83
4.3
3.1
33.61
92.84
e6/l
0.81
157
1249
571
5438
1.30
1.81
4.8
4.4
2.66
2.78
mmol/l
2.51
530
5041
16
80
2.02
1.81
1.6
1.6
—
—
—
0
0
16
80
2.02
1.81
1.6
1.6
—
—
—
0
0
193
1640
1.25
1.80
4.4
4.7
2.00
2.42
ug/l
0.56
175
1472
25
146
1.74
1.80
1.4
1.2
—
—
—
0
0
186
1575
1.25
1.79
3.8
3.1
7.17
7.95
mmol/l
1.59
168
1341
111
883
1.31
1.77
1.3
1.3
19.84
30.66
iu/ml
0.81
33
290
15
74
2.05
1.76
3.3
3.1
1.13
1.50
%
0.21
15
66
27
163
1.68
1.74
1.6
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
141
1.73
1.70
3.5
2.5
0.28
0.38
u/ml
0.92
15
72
27
165
1.66
1.67
2.0
2.4
3.33
3.59
g/l
0.75
27
152
10
41
2.46
1.65
1.6
2.4
2.60
2.29
u/field
—
5
17
157
1317
1.25
1.64
3.8
4.1
22.29
21.21
%
0.36
65
595
21
120
1.77
1.64
1.5
1.2
—
—
—
0
0
27
166
1.65
1.64
2.9
1.7
—
—
—
0
0
237
2079
1.21
1.62
4.1
3.5
—
—
—
0
0
20
113
1.79
1.62
1.6
1.6
—
—
—
0
0
58
424
1.40
1.60
2.8
2.3
10.89
12.87
nmol/l
0.98
52
381
53
382
1.42
1.58
2.5
2.4
56.15
71.72
ml/min/173m2
1.73
20
154
6
20
3.02
1.58
1.0
1.0
—
—
—
0
0
42
290
1.48
1.57
1.5
1.4
—
—
—
0
0
12
57
2.13
1.55
1.4
1.5
—
—
—
0
0
12
57
2.13
1.55
1.4
1.5
—
—
—
0
0
75
576
1.34
1.54
2.0
1.8
—
—
—
0
0
14
72
1.96
1.49
1.4
1.6
—
—
—
0
0
404
3746
1.19
1.46
3.2
3.0
51.78
44.84
u/l
0.74
378
3530
18
102
1.79
1.46
2.4
1.9
16.16
16.65
%
—
10
52
9
38
2.39
1.46
1.6
1.6
—
—
—
0
0
9
38
2.39
1.46
1.6
1.6
—
—
—
0
0
9
38
2.39
1.46
1.6
1.6
—
—
—
0
0
6
22
2.74
1.43
1.7
1.9
—
—
—
0
0
141
1188
1.24
1.41
1.7
1.7
1.14
1.17
mg/l
0.08
108
903
9
40
2.27
1.40
3.3
1.9
—
—
—
0
0
73
568
1.32
1.39
1.9
1.7
—
—
—
0
0
12
60
2.02
1.38
2.7
1.5
31.42
33.67
pg
1.10
12
60
12
60
2.02
1.38
1.4
1.7
—
—
—
0
0
36
248
1.48
1.38
6.6
10.6
23.81
24.49
mmol/l
0.56
36
242
31
207
1.52
1.37
1.7
1.6
—
—
—
0
0
6
23
2.62
1.37
1.7
1.9
—
—
—
0
0
23
144
1.62
1.33
6.7
3.4
8.18
8.48
kpa
0.35
23
139
558
5359
1.22
1.26
4.5
4.0
4.52
4.66
mmol/l
2.59
522
4996
27
179
1.53
1.25
1.2
1.3
—
—
—
0
0
105
869
1.25
1.25
3.1
2.8
0.81
0.94
e6/l
0.24
62
489
8
36
2.24
1.24
1.8
1.4
0.90
0.97
g/l
—
8
36
100
825
1.25
1.22
2.1
1.8
—
—
—
0
0
102
844
1.25
1.22
3.9
2.9
3.40
2.27
e6/l
0.62
60
465
101
836
1.24
1.20
1.2
1.3
18.80
11.34
u/ml
0.40
40
322
24
157
1.55
1.19
1.2
1.1
—
—
—
0
0
12
64
1.89
1.18
1.6
1.6
—
—
—
0
0
150
1299
1.20
1.15
3.0
2.2
—
—
—
0
0
27
183
1.49
1.15
2.0
1.7
—
—
—
0
0
544
5236
1.19
1.06
4.9
4.1
5.96
5.88
mmol/l
0.74
514
4786
552
5321
1.19
1.05
4.3
4.0
1.40
1.46
mmol/l
3.01
514
4942
23
154
1.51
1.05
2.3
2.8
—
—
—
0
0
23
155
1.50
1.02
1.2
1.1
—
—
—
0
0
12
68
1.78
1.01
1.9
1.6
—
—
—
0
0
24
165
1.47
0.98
2.0
2.3
3.57
3.63
g/l
0.08
24
159
15
92
1.64
0.97
1.2
1.2
3.45
2.86
ug/l
0.44
15
80
0
30
0.00
0.97
0.0
1.2
—
1.07
—
0
11
7
36
1.95
0.97
2.0
1.7
—
—
—
0
0
22
149
1.49
0.96
1.5
1.5
—
191.43
—
0
7
6
27
2.23
0.93
1.7
1.8
—
—
—
0
0
533
5146
1.16
0.88
17.1
11.5
81.40
85.04
ml/min/173m2
2.69
432
4172
214
1948
1.14
0.88
4.1
3.4
27.77
34.72
ng/l
0.91
147
1257
6
30
2.01
0.87
1.5
1.4
1.54
1.52
g/l
—
6
30
161
1438
1.16
0.86
4.0
3.6
0.00
0.00
estimate
0.80
60
513
8
44
1.83
0.86
2.0
1.4
—
—
—
0
0
145
1287
1.16
0.84
1.3
1.3
0.72
1.55
u/ml
1.63
37
356
48
383
1.27
0.82
2.3
2.2
4.63
8.57
ug/l
1.34
42
332
6
33
1.83
0.79
1.3
1.6
—
—
—
0
0
6
33
1.83
0.79
1.0
1.4
—
—
—
0
0
42
332
1.28
0.78
4.0
3.3
4.19
4.62
pmol/l
2.39
34
298
529
5123
1.14
0.76
4.2
3.6
1.30
1.27
mmol/l
0.53
492
4731
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
30
227
1.34
0.76
1.5
1.4
—
—
—
0
0
9
53
1.71
0.75
2.6
3.5
2.11
3.91
nmol/l
—
9
53
30
228
1.33
0.74
1.5
1.4
—
—
—
0
0
30
228
1.33
0.74
1.5
1.4
—
—
—
0
0
30
228
1.33
0.74
1.5
1.4
—
—
—
0
0
7
39
1.80
0.72
1.3
1.5
168.11
177.54
pmol/l
—
7
39
9
56
1.62
0.72
2.2
1.7
—
—
—
0
0
409
3907
1.12
0.72
3.6
3.3
—
—
—
0
0
41
328
1.27
0.71
6.0
3.8
1.03
1.87
mmol/l
0.66
33
240
7
41
1.71
0.70
1.0
1.2
—
—
—
0
0
7
42
1.67
0.68
1.0
1.2
—
—
—
0
0
18
127
1.43
0.68
1.4
1.2
—
—
—
0
0
16
112
1.44
0.64
1.3
1.4
—
—
—
0
0
5
29
1.73
0.64
1.2
2.0
—
—
—
0
0
5
29
1.73
0.64
1.2
2.0
—
—
—
0
0
37
297
1.26
0.63
1.6
1.6
—
—
—
0
0
25
190
1.33
0.63
1.4
1.4
—
—
—
0
0
15
104
1.45
0.63
2.1
1.5
—
—
—
0
0
16
222
0.71
0.62
1.4
1.3
199.50
244.30
miu/ml
—
8
112
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
12
80
1.51
0.60
1.9
1.7
—
—
—
0
0
0
22
0.00
0.59
0.0
3.2
—
208.91
—
0
22
19
140
1.37
0.59
5.0
4.2
35.66
32.46
mg/l
0.13
14
118
19
140
1.37
0.59
4.9
4.2
24.78
98.93
mg/l
1.04
13
118
6
35
1.72
0.58
1.0
1.1
—
—
—
0
0
8
54
1.49
0.57
3.4
3.9
—
—
—
0
0
61
524
1.18
0.56
2.2
1.9
—
—
—
0
0
40
332
1.22
0.53
1.3
1.3
—
—
—
0
0
18
134
1.35
0.53
2.6
2.1
13.86
11.81
mg/l
0.36
18
123
10
66
1.52
0.52
2.2
2.9
102.60
105.76
mmol/l
—
10
66
12
83
1.45
0.52
1.3
1.1
—
—
—
0
0
11
156
0.70
0.50
1.5
1.8
—
—
—
0
0
35
289
1.22
0.50
2.1
2.4
6250.02
2776.57
u/l
0.24
14
128
47
400
1.19
0.50
1.1
1.2
108.06
165.07
iu/ml
0.54
19
155
7
46
1.53
0.48
1.6
1.7
—
—
—
0
0
11
76
1.45
0.48
1.1
1.1
—
—
—
0
0
17
218
0.77
0.43
1.7
1.7
—
—
—
0
0
30
249
1.21
0.42
1.7
1.5
—
—
—
0
0
18
140
1.29
0.42
1.2
1.4
307.00
284.18
ug/g
—
8
79
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.2
1.5
5.26
6.30
mmol/l
—
5
33
5
33
1.52
0.41
1.6
1.5
9.10
6.12
u/l
—
5
26
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
361.20
—
0
10
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
16
123
1.31
0.40
1.7
2.4
392.80
76.24
ug/min
0.61
11
71
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
11
149
0.73
0.40
1.2
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
7
103
0.68
0.39
1.1
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
3.4
—
—
—
0
0
0
19
0.00
0.39
0.0
3.4
—
—
—
0
0
5
36
1.39
0.38
1.2
1.8
—
—
—
0
0
6
44
1.37
0.34
4.3
2.8
24.32
52.93
u/ml
—
6
44
14
109
1.29
0.33
1.3
1.3
—
—
—
0
0
14
109
1.29
0.33
1.3
1.3
—
—
—
0
0
20
164
1.23
0.33
1.2
1.5
1.19
1.21
g/l
0.13
20
155
7
54
1.30
0.30
1.6
1.6
—
—
—
0
0
35
307
1.15
0.29
1.0
1.0
—
—
—
0
0
8
109
0.73
0.29
2.0
1.8
—
—
—
0
0
7
57
1.23
0.29
1.4
1.2
—
—
—
0
0
19
158
1.21
0.28
1.2
1.5
0.24
0.24
g/l
0.01
19
152
102
956
1.08
0.27
3.0
2.9
0.71
0.75
ug/l
0.22
63
614
26
226
1.16
0.25
2.2
2.0
34.71
39.26
u/l
0.63
21
203
12
148
0.81
0.24
1.4
1.3
—
—
—
0
0
9
76
1.19
0.24
1.3
1.3
—
—
—
0
0
9
76
1.19
0.24
1.2
1.1
—
—
—
0
0
6
85
0.70
0.24
2.2
5.4
292.00
376.19
umol/l
—
6
75
14
116
1.21
0.22
1.4
1.4
934.07
1068.86
e6/l
0.04
14
92
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
8.06
—
0
8
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
24.17
—
0
14
13
108
1.21
0.20
1.5
1.7
—
—
—
0
0
52
482
1.09
0.19
2.7
2.3
31.53
33.52
u/l
0.20
47
404
19
168
1.13
0.16
1.0
1.1
1.18
6.00
u/ml
—
5
23
15
130
1.16
0.15
1.1
1.4
516.33
434.57
mg/l
0.23
15
122
14
123
1.14
0.12
2.1
1.9
168.50
232.08
pmol/l
2.19
14
113
51
483
1.06
0.12
2.8
4.1
8.00
33.81
ug/l
0.89
39
404
56
587
0.95
0.11
10.2
6.1
—
—
—
0
0
53
555
0.95
0.10
1.8
1.6
—
—
—
0
0
138
1414
0.97
0.10
1.8
1.6
1.44
1.38
mmol/l
0.31
116
1204
39
412
0.94
0.10
2.4
1.8
—
—
—
0
0
71
735
0.96
0.09
1.8
1.8
1.47
1.42
%
0.19
66
648
22
204
1.08
0.08
2.4
1.8
—
—
—
0
0
5
60
0.83
0.08
3.2
2.4
—
—
—
0
0
9
88
1.02
0.07
1.3
1.5
6.88
7.30
mmol/l
—
9
75
8
90
0.89
0.07
1.3
1.1
—
19.03
—
0
23
11
121
0.91
0.06
1.1
1.4
—
—
—
0
0
10
90
1.11
0.05
1.2
1.1
—
—
—
0
0
15
161
0.93
0.05
1.3
1.5
—
—
—
0
0
15
140
1.07
0.04
1.5
1.7
3.63
5.59
iu/l
—
6
46
39
379
1.03
0.03
2.5
2.3
50.54
19.21
au/ml
—
5
24
89
903
0.98
0.03
2.6
2.2
—
—
—
0
0
10
92
1.09
0.03
1.3
1.4
31.62
23.10
u/l
—
10
74
10
108
0.92
0.03
1.0
1.2
—
40.27
—
0
7
81
822
0.98
0.03
2.3
2.0
—
—
—
0
0
22
228
0.96
0.02
1.8
1.8
—
—
—
0
0
11
103
1.07
0.02
1.6
1.5
0.17
0.37
nmol/l
1.83
11
84
12
114
1.05
0.00
1.1
1.3
3.42
3.68
mmol/l
0.55
12
105
91
916
0.99
0.00
1.4
1.5
—
—
—
0
0
19
193
0.98
0.00
2.5
1.7
—
—
—
0
0
10
98
1.02
0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
65.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.0
1.1
—
—
—
0
0
6
68
0.88
0.00
2.3
1.4
—
—
—
0
0
6
68
0.88
0.00
1.8
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
0.00
2.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
10.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
2.3
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
67
0.89
-0.00
1.8
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.7
—
24.43
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
9
98
0.92
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
1.7
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
67
0.89
-0.00
1.8
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
12
120
1.00
-0.00
2.3
1.6
0.78
0.90
nmol/l
0.30
12
101
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
2.1
1.7
13.56
13.11
%
—
7
73
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PYOGENGRANUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.543 [1.27, 1.88] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 1977 females with L12_PYOGENGRANUL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYOGENGRANUL | 1.421 [1.16, 1.73] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 274 out of 1844 males with L12_PYOGENGRANUL died.
Mortality risk
Mortality risk for people of age
years, who have L12_PYOGENGRANUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.179% | 0.302% |
| 5 | 1.04% | 1.5% |
| 10 | 2.355% | 4.318% |
| 15 | 4.488% | 8.409% |
| 20 | 7.648% | 14.355% |
Relationships between endpoints
↥Index endpoint: L12_PYOGENGRANUL – Pyogenic granuloma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data