cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).
Other specified/unspecified disorders of bone/cartilage
DOID EFO Endpoint Browser PheWeb
M13_BONEDISNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1073 |
4. Check minimum number of eventsNone |
1073 |
5. Include endpointsNone |
1073 |
6. Filter based on genotype QC (FinnGen only) |
1050 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified disorders of bone/cartilage
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8627 | 3501 | 5069 |
| Only index persons | 7527 | 3030 | 4497 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.14 |
| Only index persons | 0.15 | 0.11 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 30.25 | 43.37 | 20.93 |
| Only index persons | 28.79 | 40.76 | 20.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1050 | 484 | 566 |
| Unadjusted period prevalence (%) | 0.22 | 0.17 | 0.26 |
| Median age at first event (years) | 32.58 | 42.83 | 23.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1073
- Matched controls
- 10730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
72398
ICD-8 Finland
Other diseases of bone, Alii definiti
+∞
307.7
352
*
M94.9
ICD-10 Finland
Disorder of cartilage, unspecified
1013.5
179.7
171
*
M89.9
ICD-10 Finland
Disorder of bone, unspecified
+∞
177.1
165
*
M94.8
ICD-10 Finland
Other specified disorders of cartilage
1222.9
114.8
110
*
72399
ICD-8 Finland
Other diseases of bone
+∞
110.3
104
*
7339X
ICD-9 Finland
Other disorders of bone and cartilage, Other and unspecified disorders of bone and cartilage
+∞
101.7
96
*
M89.88
ICD-10 Finland
Other specified disorders of bone, other
+∞
77.0
73
*
9102
FHL
Trepanation or removal of the local bone process
32.0
75.1
49
16
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
16.2
41.9
36
23
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.7
35.2
119
347
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
4.9
31.7
72
155
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.7
29.0
41
55
M89.0
ICD-10 Finland
Algoneurodystrophy
106.3
28.8
31
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
24.1
496
3302
N03AX16
ATC
[U] pregabalin
2.1
22.5
272
1497
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.1
21.7
259
1416
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
8.2
21.0
28
35
M25.5
ICD-10 Finland
Pain in joint
1.9
20.1
372
2357
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.4
20.1
161
747
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
19.1
143
644
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
5.2
18.5
38
75
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
18.3
321
1989
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.3
18.2
147
683
M54.5
ICD-10 Finland
Low back pain
1.8
17.9
395
2624
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.2
17.8
160
779
R51.80
ICD-10 Finland
Headache
2.1
17.2
178
915
M03BX02
ATC
tizanidine; oral
1.7
16.6
686
5403
M79.6
ICD-10 Finland
Pain in limb
1.7
15.2
437
3095
1220
FHL
Arthroscopy
3.2
15.1
62
204
H02AB06
ATC
prednisolone; systemic
1.7
14.9
494
3624
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
14.9
301
1929
M01AB05
ATC
diclofenac; systemic, rectal
1.7
14.7
715
5789
M01AH05
ATC
etoricoxib; oral
1.7
14.5
683
5471
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
14.5
138
685
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
14.2
203
1167
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
14.0
364
2494
M23.8
ICD-10 Finland
Other internal derangements of knee
3.3
14.0
52
161
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
5.3
14.0
28
54
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
14.0
485
3583
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
13.9
391
2734
N03AX12
ATC
[U] gabapentin; oral
1.9
13.4
182
1028
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
13.0
453
3331
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
12.7
114
552
M02AA07
ATC
piroxicam; topical
1.6
12.6
375
2649
M94.2
ICD-10 Finland
Chondromalacia
+∞
12.5
12
*
R03DC03
ATC
montelukast; oral
1.9
12.4
175
998
N06AX21
ATC
duloxetine; oral
2.0
12.4
136
712
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
12.3
96
438
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
12.3
120
601
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
4.7
12.2
28
61
J01FF01
ATC
clindamycin; systemic
1.7
12.2
282
1863
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.7
12.1
67
260
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.1
11.7
116
584
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
11.7
203
1235
L15
ICPC
Knee symptom/complaint
1.7
11.6
243
1558
J01AA02
ATC
doxycycline; systemic
1.7
11.6
809
6942
WX002
NOMESCO Finland
Sedation and analgesia
1.8
11.3
194
1174
A03FA02
ATC
cisapride; oral, rectal
2.4
11.3
81
356
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
11.2
221
1392
N06AX16
ATC
venlafaxine; oral
1.9
11.2
153
862
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
11.2
454
3427
M01AH01
ATC
celecoxib; oral
1.8
11.1
189
1141
R03AC02
ATC
salbutamol; inhalant
1.5
10.7
552
4380
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.0
10.6
113
584
B01AB05
ATC
enoxaparin; parenteral
1.6
10.6
306
2127
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
10.5
102
510
M77.4
ICD-10 Finland
Metatarsalgia
2.4
10.4
71
306
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
10.3
285
1958
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
10.1
299
2086
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
10.1
176
1068
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
10.0
80
369
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.6
10.0
60
243
X58
ICD-10 Finland
Exposure to other specified factors
1.8
9.9
155
910
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.3
9.9
25
59
N06AA09
ATC
amitriptyline; systemic
2.1
9.8
98
495
A02BC01
ATC
omeprazole; systemic
1.6
9.7
263
1797
R02
ICPC
Shortness of breath/dyspnoea
1.9
9.6
126
700
L17
ICPC
Foot/toe symptom/complaint
1.6
9.6
271
1869
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
4.7
9.6
22
48
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
9.5
184
1149
KH1AD
NOMESCO Finland
CT of urinary organs
2.9
9.5
43
150
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
9.4
9
*
M89.81
ICD-10 Finland
Other specified disorders of bone, shoulder region
+∞
9.4
9
*
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
21.9
9.4
13
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
9.3
114
619
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
9.3
84
408
N02AA05
ATC
oxycodone; systemic
1.8
9.2
164
1001
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.2
213
1396
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.0
9.2
100
521
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
9.2
173
1073
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
9.1
228
1523
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
9.1
207
1350
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
9.0
100
524
S60.2
ICD-10 Finland
Contusion of other parts of wrist and hand
2.5
9.0
55
225
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
18.8
8.9
13
7
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
8.9
72
334
S29
ICPC
Skin symptom/complaint other
1.7
8.9
176
1107
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.8
8.8
45
168
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.9
8.8
116
646
R96
ICPC
Asthma
2.0
8.8
94
487
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
8.7
73
344
M05BA06
ATC
ibandronic acid; systemic
4.3
8.7
22
52
9476
FHL
Splitting of fascia or aponeurosis
6.7
8.7
21
32
UJF32
NOMESCO Finland
Coloscopy
1.6
8.7
255
1770
A02BA02
ATC
ranitidine; systemic
1.7
8.6
190
1229
T92.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of upper limb
7.0
8.6
20
29
M01AX17
ATC
nimesulide; oral
1.6
8.5
230
1563
A02BC02
ATC
pantoprazole; systemic
1.5
8.5
676
5742
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
8.4
404
3109
M01AE02
ATC
naproxen; oral, rectal
1.5
8.4
573
4719
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
3.4
8.4
29
86
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
8.6
8.3
17
20
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.3
370
2804
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.9
8.3
110
614
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
8.2
147
898
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.1
254
1783
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.1
225
1536
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.4
8.1
29
88
L03
ICPC
Low back symptom/complaint
1.5
8.1
259
1830
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.0
7.9
80
406
H02AB04
ATC
methylprednisolone; systemic
1.7
7.8
140
856
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
7.7
264
1889
A02BC05
ATC
esomeprazole; systemic
1.5
7.6
396
3080
NDA30
NOMESCO Finland
Exploration of joint of wrist or hand, arthroscopic
8.1
7.6
16
20
M22.4
ICD-10 Finland
Chondromalacia patellae
2.9
7.6
35
124
M01AX05
ATC
glucosamine; oral
1.6
7.5
180
1185
M01AH02
ATC
rofecoxib; oral
1.8
7.5
123
733
9101
FHL
Bone biopsy
80.6
7.4
8
*
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
80.6
7.4
8
*
R07.3
ICD-10 Finland
Other chest pain
1.9
7.4
102
576
M05BA04
ATC
alendronic acid; oral
2.2
7.3
61
287
H02AB07
ATC
prednisone; oral
1.7
7.3
127
768
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.3
246
1752
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.3
122
731
M05BX04
ATC
denosumab; parenteral
2.6
7.2
41
162
R06AE07
ATC
cetirizine; oral
1.4
7.0
403
3183
JN4AD
NOMESCO Finland
Body CT examination
1.8
7.0
97
549
R03BA08
ATC
ciclesonide; inhalant
1.9
7.0
85
461
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.9
6.9
90
499
R03BA01
ATC
beclometasone; inhalant
1.7
6.9
132
820
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
13.9
6.9
11
8
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
3.2
6.9
27
87
WX320
NOMESCO Finland
Spinalanesthesy
1.5
6.9
223
1573
ZXA05
NOMESCO Finland
Left side
1.5
6.9
228
1616
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.1
6.9
66
329
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.5
6.8
43
179
M09AX01
ATC
hyaluronic acid; parenteral
2.4
6.8
46
198
J01FA06
ATC
roxithromycin; oral
1.4
6.8
383
3010
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
6.8
84
458
R07.2
ICD-10 Finland
Precordial pain
3.1
6.8
27
88
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.8
139
880
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
2.4
6.8
47
205
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
6.7
333
2555
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.7
907
8328
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.7
6.7
137
867
N06AX11
ATC
mirtazapine; oral
1.4
6.7
323
2468
L02
ICPC
Back symptom/complaint
1.8
6.6
95
543
E0000UV, ,
ATC
1.4
6.6
377
2965
M77.1
ICD-10 Finland
Lateral epicondylitis
1.9
6.6
87
484
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.0
6.6
69
355
M01AB55
ATC
diclofenac, combinations; oral
2.1
6.6
64
321
SPAT1229
SPAT
Assessment of need for aid
2.0
6.5
65
328
N30.9
ICD-10 Finland
Cystitis, unspecified
2.2
6.5
51
234
S18
ICPC
Laceration/cut
1.4
6.5
424
3410
R05FB02
ATC
cough suppressants and expectorants; systemic
1.4
6.5
347
2697
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.5
450
3659
R04.0
ICD-10 Finland
Epistaxis
2.0
6.5
73
386
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.2
6.5
54
255
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
6.5
152
996
J01DB01
ATC
cefalexin; oral
1.5
6.4
836
7562
J02AC01
ATC
fluconazole; systemic
1.4
6.4
330
2544
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
3.4
6.4
22
65
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.3
6.4
23
70
Y0899
ICD-8 Finland
Investigation of musculoskeletal system
7.5
6.4
14
19
ZXA00
NOMESCO Finland
Right side
1.5
6.4
242
1763
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.3
126
791
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.3
89
506
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
6.3
46
205
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
6.3
702
6164
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
1.7
6.3
113
691
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.6
6.3
34
132
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
+∞
6.3
6
*
L28
ICPC
Limited function/disability (L)
1.6
6.3
141
914
L29
ICPC
Musculoskeletal sympt/complt other
1.9
6.2
75
405
M84.8
ICD-10 Finland
Other disorders of continuity of bone
26.8
6.2
8
*
S63.3
ICD-10 Finland
Traumatic rupture of ligament of wrist and carpus
3.6
6.2
20
57
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
6.1
104
625
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.1
169
1149
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.2
6.1
50
234
J01DA01
ATC
[U] cefalexin
1.4
6.1
602
5165
ZXE00
NOMESCO Finland
One hour or less
1.4
6.1
354
2786
J01FA10
ATC
azithromycin; systemic
1.4
6.1
554
4693
WZA90
NOMESCO Finland
Other medical or dental certificate
1.5
6.1
218
1568
R03BA05
ATC
fluticasone; inhalant
1.6
6.0
166
1129
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
785
6547
1.74
14.16
8.2
7.2
76.61
77.01
u/l
0.09
742
6168
484
3578
1.64
13.86
7.7
5.8
1.21
1.21
mmol/l
0.41
445
3269
514
3860
1.64
13.80
11.4
13.3
1.28
1.24
inr
0.34
150
1141
466
3458
1.61
12.84
4.9
4.8
35.94
35.90
g/l
0.06
441
3234
556
4325
1.59
12.43
6.0
6.2
10.79
11.47
umol/l
0.88
537
4107
371
2635
1.62
12.05
2.7
2.5
58.34
60.36
u/l
0.18
345
2446
439
3296
1.56
11.02
2.7
2.1
76.60
75.54
nmol/l
0.35
394
2960
507
3940
1.54
10.84
9.0
6.4
1.21
1.21
mmol/l
0.24
431
3387
743
6310
1.58
10.43
4.8
3.9
11.45
11.17
mm/h
0.23
703
5843
429
3252
1.53
10.06
4.5
3.3
29.32
58.35
ng/l
1.35
312
2219
168
1018
1.77
9.68
6.0
5.8
1.05
1.03
mmol/l
0.33
159
947
177
1093
1.74
9.55
2.9
2.4
23.33
23.36
%
0.01
156
945
187
1173
1.72
9.54
2.7
2.3
2.27
2.36
g/l
1.26
177
1098
106
561
1.99
9.31
1.7
1.6
—
—
—
0
0
196
1263
1.68
9.02
2.8
2.3
13.59
13.52
umol/l
0.05
183
1185
238
1613
1.61
8.96
1.6
1.4
2.36
2.51
g/l
0.68
153
1022
606
5020
1.48
8.78
5.5
4.6
6.73
6.72
mmol/l
0.03
580
4693
54
227
2.45
8.36
3.0
3.4
27.13
33.80
mg/l
0.92
47
180
498
3999
1.46
8.30
5.9
5.7
57.13
56.87
%
0.20
472
3771
503
4051
1.45
8.23
6.3
5.9
28.07
28.21
%
0.10
477
3818
53
224
2.44
8.12
3.0
3.3
2.85
2.04
ratio
—
5
18
53
227
2.40
7.90
3.0
3.4
39.68
71.91
mg/l
0.59
46
181
636
5379
1.45
7.87
5.1
4.0
1701.83
2647.32
e6/l
—
6
85
486
3916
1.44
7.79
2.6
2.5
—
—
—
0
0
107
605
1.85
7.71
2.4
2.5
66.76
66.80
g/l
0.02
98
568
582
4853
1.44
7.71
8.5
9.0
4.06
4.08
e9/l
0.09
521
4251
237
1667
1.54
7.47
2.6
2.5
6.29
5.27
e6/l
0.39
209
1504
183
1226
1.59
7.11
2.0
1.8
—
—
—
0
0
193
1331
1.55
6.59
3.6
3.5
0.81
0.82
mmol/l
0.29
177
1264
320
2446
1.44
6.57
3.8
3.0
28.89
91.42
e6/l
1.50
252
1871
945
8774
1.65
6.51
17.1
12.6
21.09
23.66
mg/l
1.78
790
6886
295
2226
1.45
6.48
3.6
2.9
0.37
0.45
e6/l
0.32
229
1670
155
1022
1.60
6.41
2.8
2.3
122.92
138.23
ug/g
0.27
119
828
131
837
1.64
6.15
2.3
2.6
1.84
1.80
%
0.14
112
757
280
2114
1.44
6.08
4.2
3.7
92.05
91.31
%
0.19
270
2070
256
1905
1.45
5.99
1.8
1.7
1.27
1.08
mg/l
0.36
193
1456
300
2300
1.42
5.97
2.8
2.5
2351.67
5648.87
umol/l
0.86
267
2047
200
1423
1.50
5.87
1.4
1.3
20.78
33.15
iu/ml
1.34
66
479
93
551
1.75
5.77
4.6
3.7
77.95
83.17
ng/l
0.27
75
492
323
2528
1.40
5.66
2.3
2.1
255.25
252.45
u/l
0.01
305
2384
151
1021
1.56
5.60
4.9
4.5
31.16
31.41
%
0.10
106
696
367
2942
1.38
5.55
4.0
3.0
—
—
—
0
0
335
2651
1.38
5.47
3.1
3.3
2.34
2.35
mmol/l
0.58
288
2358
63
337
1.92
5.43
1.7
2.0
1.45
1.59
g/l
0.64
52
300
244
1843
1.42
5.19
1.6
1.5
21.04
20.90
nmol/l
0.04
197
1589
11
15
7.40
5.15
2.1
2.1
98.36
61.05
ug/l
0.78
11
15
151
1042
1.52
5.10
8.0
6.4
—
—
—
0
0
114
740
1.60
5.03
2.2
2.1
357.63
369.46
nmol/l
0.28
104
682
296
2324
1.38
5.00
3.1
2.8
984.66
1127.45
ng/l
0.38
250
1959
129
872
1.54
4.79
3.5
4.2
235.71
239.94
u/l
0.19
123
829
38
177
2.19
4.77
1.2
1.2
6.59
6.48
e6/l
0.01
29
133
38
177
2.19
4.77
1.2
1.3
248.55
1205.78
e6/l
0.66
29
139
50
259
1.98
4.75
1.4
1.5
283.36
275.17
ug/g
0.09
33
155
74
435
1.75
4.75
1.9
1.6
—
—
—
0
0
392
3244
1.33
4.63
2.2
1.9
97.13
94.63
pmol/l
0.45
197
1724
43
213
2.06
4.62
1.2
1.2
4.68
2.69
u/ml
—
6
23
683
6107
1.33
4.62
3.4
3.1
46.06
50.83
u/l
1.05
640
5741
49
255
1.97
4.61
1.4
1.8
—
—
—
0
0
12
22
5.50
4.61
3.2
4.5
—
—
—
0
0
43
215
2.04
4.52
1.2
1.2
3.02
10.00
u/ml
—
6
32
112
746
1.56
4.44
4.8
3.5
5.84
5.83
kpa
0.01
107
727
111
739
1.56
4.41
4.8
3.6
1.06
2.11
mmol/l
1.61
93
608
253
1972
1.37
4.41
2.4
2.2
—
—
—
0
0
96
622
1.60
4.29
3.8
2.8
4.64
4.59
kpa
0.07
90
602
420
3538
1.31
4.29
3.3
2.7
137.96
143.36
ug/l
0.19
389
3266
332
2707
1.33
4.28
3.4
3.0
7.97
8.08
mmol/l
0.15
272
2300
49
264
1.90
4.19
1.6
1.6
—
—
—
0
0
38
187
2.07
4.18
1.4
1.5
—
—
—
0
0
124
858
1.50
4.14
1.8
1.8
—
—
—
0
0
173
1278
1.42
4.12
1.9
1.9
30.09
29.61
s
0.29
165
1240
850
7905
1.36
4.05
5.2
4.4
1.86
2.05
mu/l
0.64
768
7258
53
297
1.83
4.02
2.7
2.0
6.78
7.27
g/l
1.56
47
277
53
297
1.83
4.02
2.7
2.0
—
—
—
0
0
53
297
1.83
4.02
2.7
2.0
3.37
3.61
g/l
0.76
47
277
122
847
1.50
4.01
1.8
1.7
—
—
—
0
0
188
1418
1.40
3.97
1.8
1.7
1151.03
1169.85
nmol/l
0.11
132
1067
229
1785
1.36
3.95
1.3
1.3
0.81
1.36
u/ml
1.22
56
493
895
8402
1.39
3.95
15.6
11.7
81.86
82.81
ml/min/173m2
0.64
762
6908
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
45
241
1.91
3.93
3.2
2.6
0.32
0.34
u/ml
0.14
26
135
622
5561
1.28
3.85
3.0
2.9
—
—
—
0
0
953
9074
1.45
3.61
19.9
14.4
139.55
139.71
mmol/l
1.16
934
8840
107
740
1.50
3.60
8.4
6.6
1.51
1.43
mmol/l
0.27
107
725
34
171
2.02
3.57
1.3
1.4
—
—
—
0
0
35
178
2.00
3.57
1.2
1.1
14.60
34.66
u/ml
—
6
13
873
8210
1.34
3.42
6.2
5.5
39.87
39.77
mmol/mol
0.12
794
7675
274
2235
1.30
3.42
4.9
3.5
0.00
0.01
estimate
0.88
105
764
15
53
2.86
3.36
1.0
1.0
910.60
679.00
ng/l
—
10
32
15
53
2.86
3.36
1.0
1.0
291.50
226.36
ng/l
—
10
33
15
53
2.86
3.36
1.0
1.0
40.30
31.07
ng/l
—
10
31
478
4184
1.26
3.36
4.6
3.3
0.00
0.01
estimate
0.80
106
738
40
218
1.87
3.35
1.3
1.2
—
—
—
0
0
48
277
1.77
3.35
2.4
2.0
2.59
2.86
g/l
1.69
42
257
47
270
1.77
3.34
2.6
2.0
9.38
10.42
g/l
0.77
41
249
954
9112
1.42
3.29
19.9
14.5
3.99
3.98
mmol/l
0.49
934
8867
180
1390
1.35
3.28
1.3
1.2
2.84
10.52
u/ml
3.69
64
554
305
2539
1.28
3.24
3.6
3.2
727.94
327.05
mg/l
0.52
190
1648
77
508
1.56
3.24
3.8
3.1
1.66
1.66
mmol/l
0.00
63
372
43
245
1.79
3.15
2.2
2.1
0.78
0.91
g/l
0.10
37
225
106
753
1.45
3.14
2.1
2.3
0.21
0.22
g/l
0.67
99
718
118
858
1.42
3.08
2.9
2.2
13.31
13.48
nmol/l
0.09
106
789
240
1953
1.29
3.02
2.6
2.1
2.87
3.02
mg/l
0.56
202
1662
125
924
1.40
2.98
2.4
2.8
6.04
8.66
umol/l
1.72
108
801
16
63
2.56
2.96
1.0
1.0
—
—
—
0
0
13
46
2.85
2.92
1.5
1.5
—
—
—
0
0
13
46
2.85
2.92
1.5
1.5
—
—
—
0
0
60
384
1.60
2.89
2.2
2.0
39.23
39.16
u/l
0.01
48
343
17
70
2.45
2.89
4.3
2.9
—
—
—
0
0
982
9462
1.45
2.88
12.0
9.8
28.11
27.91
u/l
0.11
957
9148
23
109
2.13
2.86
1.4
1.5
—
—
—
0
0
50
307
1.66
2.84
2.1
1.8
—
—
—
0
0
468
4142
1.23
2.83
5.8
4.5
0.00
0.00
estimate
0.50
110
793
316
2681
1.25
2.81
4.0
3.7
15.07
7.67
mg/mmol
0.59
202
1730
183
1449
1.32
2.81
1.5
1.5
—
—
—
0
0
50
310
1.64
2.75
2.5
2.0
1.58
2.18
ug/l
0.19
45
285
39
227
1.75
2.70
1.7
1.9
37.77
37.81
g/l
0.01
33
207
698
6457
1.23
2.69
4.4
3.7
14.78
14.73
pmol/l
0.25
630
5875
98
712
1.41
2.60
2.4
2.3
5.89
7.73
ug/l
0.59
75
635
9
25
3.62
2.57
1.6
1.8
—
—
—
0
0
9
25
3.62
2.57
1.6
1.8
—
—
—
0
0
44
269
1.66
2.57
1.8
1.6
0.04
0.25
iu/ml
—
8
47
12
42
2.88
2.55
1.5
1.5
—
—
—
0
0
12
42
2.88
2.55
1.5
1.5
—
—
—
0
0
101
741
1.40
2.54
2.6
2.5
29.41
41.06
u/l
1.13
86
649
22
108
2.06
2.53
1.4
1.5
—
—
—
0
0
22
108
2.06
2.53
1.4
1.5
—
—
—
0
0
173
1380
1.30
2.52
3.4
2.6
0.73
1.00
e6/l
1.70
105
776
9
26
3.48
2.48
1.7
1.8
—
—
—
0
0
22
109
2.04
2.47
1.4
1.5
—
—
—
0
0
22
109
2.04
2.47
1.4
1.5
—
—
—
0
0
46
288
1.62
2.46
1.9
1.7
—
—
—
0
0
39
235
1.68
2.41
1.5
1.4
6.70
9.11
u/l
0.96
30
192
463
4142
1.21
2.40
4.5
3.3
0.00
0.00
estimate
0.50
111
833
371
3254
1.21
2.35
4.6
3.4
—
—
—
0
0
207
1706
1.26
2.33
1.8
1.7
37278521.27
37123232.75
pmol/l
0.00
169
1425
85
616
1.41
2.31
2.4
2.4
18.17
20.16
au/ml
—
6
49
21
106
2.00
2.26
1.0
1.1
—
—
—
0
0
69
483
1.46
2.26
1.3
1.4
—
—
—
0
0
37
225
1.67
2.23
2.0
2.1
11.97
11.78
mg/l
0.05
32
213
30
172
1.77
2.22
2.4
2.7
16.34
16.67
%
0.16
18
94
21
107
1.98
2.21
1.4
1.5
—
—
—
0
0
33
195
1.71
2.21
1.5
1.6
—
—
—
0
0
19
94
2.04
2.17
1.5
1.7
—
—
—
0
0
10
36
2.79
2.14
1.5
1.6
—
—
—
0
0
10
36
2.79
2.14
1.5
1.6
—
—
—
0
0
49
324
1.54
2.12
4.0
3.3
24.52
24.88
mmol/l
0.33
49
308
5
10
5.02
2.07
1.2
1.0
—
—
—
0
0
322
2817
1.20
2.05
3.2
3.3
29.87
32.26
u/l
1.27
306
2687
70
505
1.41
1.98
4.1
3.0
129.80
130.83
g/l
0.14
70
499
10
39
2.58
1.94
1.0
1.4
—
—
—
0
0
58
406
1.45
1.94
1.0
1.0
—
—
—
0
0
22
120
1.85
1.93
1.4
1.2
—
—
—
0
0
191
1594
1.24
1.93
4.3
3.6
588.85
467.85
ng/l
0.15
135
1230
24
136
1.78
1.88
1.5
1.7
—
—
—
0
0
24
136
1.78
1.88
1.5
1.7
—
—
—
0
0
24
136
1.78
1.88
1.5
1.7
—
—
—
0
0
107
835
1.31
1.86
3.5
3.2
—
—
—
0
0
17
86
1.99
1.85
1.5
1.7
—
—
—
0
0
6
17
3.54
1.84
1.0
1.1
1.65
2.22
mmol/l
—
6
17
19
101
1.90
1.81
1.3
1.1
—
—
—
0
0
17
87
1.97
1.80
1.3
1.3
8469.70
212814.32
e6/l
—
10
63
25
146
1.73
1.78
1.2
1.6
—
—
—
0
0
156
1287
1.25
1.76
4.0
2.8
2.64
2.34
e6/l
0.12
87
694
30
186
1.63
1.73
1.5
1.7
—
—
—
0
0
17
89
1.92
1.70
1.0
1.0
—
—
—
0
0
15
75
2.01
1.70
1.3
1.5
—
—
—
0
0
15
75
2.01
1.70
1.3
1.5
—
—
—
0
0
15
75
2.01
1.70
1.3
1.5
—
—
—
0
0
90
696
1.32
1.69
2.8
2.6
66.60
68.97
ml/min/173m2
0.26
39
272
29
181
1.62
1.64
3.2
2.4
131.95
132.84
g/l
0.07
22
140
115
923
1.28
1.64
10.1
7.9
0.31
1.00
mmol/l
0.88
96
747
17
91
1.88
1.61
4.4
7.0
11.61
11.35
mg/l
0.10
17
84
64
474
1.37
1.60
3.8
3.2
4.39
4.57
pmol/l
0.87
58
410
169
1422
1.22
1.60
3.0
3.1
2.44
2.44
mmol/l
0.26
145
1249
15
77
1.96
1.59
1.0
1.1
—
—
—
0
0
38
256
1.50
1.57
2.6
2.5
—
—
—
0
0
11
50
2.21
1.57
1.0
1.1
—
—
—
0
0
15
78
1.94
1.54
1.1
1.1
—
—
—
0
0
17
93
1.84
1.52
1.4
2.3
34.00
33.29
pg
0.32
17
93
69
524
1.34
1.49
1.1
1.2
121.33
141.70
iu/ml
0.12
24
206
81
630
1.31
1.48
5.0
3.7
1.22
1.23
mmol/l
0.61
73
546
73
560
1.33
1.47
1.3
1.3
37.72
51.60
au/ml
—
5
37
103
828
1.27
1.47
3.8
4.2
12.04
15.78
ug/l
0.17
85
676
5
16
3.13
1.44
1.0
1.0
—
—
—
0
0
5
16
3.13
1.44
1.0
1.0
—
—
—
0
0
148
1243
1.22
1.44
1.9
1.9
1.50
1.46
%
0.19
123
1103
13
66
1.98
1.43
1.2
1.1
—
—
—
0
0
13
66
1.98
1.43
1.5
1.8
16.39
20.65
nmol/l
1.45
13
61
6
22
2.74
1.43
1.3
1.2
—
—
—
0
0
16
88
1.83
1.42
1.4
1.5
169.16
280.34
pmol/l
0.53
16
88
24
149
1.62
1.42
1.7
1.7
—
—
—
0
0
6
136
0.44
1.41
1.5
1.6
—
—
—
0
0
19
111
1.72
1.39
1.3
1.5
—
—
—
0
0
19
111
1.72
1.39
1.0
1.1
—
—
—
0
0
209
1822
1.18
1.37
4.8
3.4
1.02
1.02
kg/l
0.62
22
243
34
233
1.47
1.33
1.3
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
54
2.05
1.33
1.0
1.1
—
—
—
0
0
15
83
1.82
1.31
1.3
1.3
—
—
—
0
0
20
121
1.67
1.31
1.2
1.6
—
—
—
0
0
9
44
2.05
1.27
1.6
1.8
—
—
—
0
0
13
70
1.87
1.24
1.4
1.7
—
—
—
0
0
13
70
1.87
1.24
1.1
1.1
—
—
—
0
0
13
70
1.87
1.24
1.1
1.1
—
—
—
0
0
13
71
1.84
1.19
1.1
1.1
—
—
—
0
0
13
71
1.84
1.19
1.1
1.1
—
—
—
0
0
13
71
1.84
1.19
1.1
1.1
—
—
—
0
0
18
110
1.65
1.16
1.4
1.6
75.00
61.77
%
0.82
11
74
20
126
1.60
1.15
1.3
1.5
—
—
—
0
0
52
398
1.32
1.12
14.5
9.9
23.17
24.23
mmol/l
1.41
52
391
49
372
1.33
1.11
5.8
3.5
48.91
49.84
%
0.09
49
367
884
8594
1.16
1.11
4.9
4.4
6.06
5.96
mmol/l
0.85
797
7896
47
355
1.34
1.10
1.6
1.8
6.02
4.82
mg/l
0.15
34
266
22
144
1.54
1.09
1.3
1.1
—
—
—
0
0
5
21
2.39
1.09
1.2
1.0
—
—
—
0
0
11
59
1.87
1.07
2.2
2.7
42.17
45.14
%
—
6
33
1005
9887
1.26
1.07
25.4
18.8
40.72
40.85
%
0.30
961
9286
75
607
1.25
1.06
2.2
2.9
137.05
180.06
ng/l
0.54
70
544
15
240
0.62
1.04
1.2
1.4
—
—
—
0
0
5
22
2.28
1.03
3.4
1.5
—
—
—
0
0
1005
9891
1.25
1.03
25.1
18.7
250.02
247.62
e9/l
0.58
989
9639
7
34
2.07
1.03
1.0
1.1
—
—
—
0
0
23
155
1.49
1.01
3.6
3.2
3.93
4.24
e9/l
0.32
23
155
31
222
1.41
1.01
1.9
2.3
1688.55
3320.79
u/l
0.39
13
84
1005
9897
1.24
0.98
25.1
18.7
4.52
4.56
e12/l
1.65
986
9625
31
224
1.40
0.97
1.8
1.7
—
—
—
0
0
7
36
1.95
0.97
1.0
1.1
64.71
79.39
u/l
—
7
36
7
36
1.95
0.97
1.0
1.1
15.57
19.61
u/l
—
7
36
14
85
1.66
0.94
1.2
1.3
—
—
—
0
0
1005
9901
1.24
0.94
25.2
18.8
136.78
137.91
g/l
1.59
994
9761
7
37
1.90
0.94
1.3
1.5
—
—
—
0
0
7
37
1.90
0.94
1.3
1.5
—
—
—
0
0
56
446
1.27
0.93
1.3
1.3
—
—
—
0
0
6
28
2.15
0.91
1.0
1.1
—
—
—
0
0
32
236
1.37
0.90
1.5
1.4
—
—
—
0
0
11
63
1.75
0.90
3.5
3.1
19.31
66.23
u/ml
1.12
11
63
13
79
1.65
0.88
1.2
1.3
—
—
—
0
0
8
43
1.87
0.87
1.5
1.6
—
—
—
0
0
23
161
1.44
0.87
3.9
3.5
56.87
55.12
%
0.38
23
161
6
30
2.01
0.87
1.0
1.1
—
—
—
0
0
6
30
2.01
0.87
1.0
1.1
—
—
—
0
0
8
44
1.82
0.86
1.5
1.6
—
—
—
0
0
21
145
1.46
0.85
1.2
1.1
1.00
36.50
iu/ml
—
6
31
17
112
1.53
0.85
1.0
1.1
—
—
—
0
0
14
88
1.60
0.84
1.5
1.8
—
—
—
0
0
8
47
1.71
0.80
1.4
1.3
—
—
—
0
0
18
122
1.48
0.80
1.1
1.0
2.01
2.27
u/ml
—
7
60
41
321
1.29
0.80
2.3
1.8
—
—
—
0
0
20
139
1.45
0.79
1.4
1.2
—
—
—
0
0
20
139
1.45
0.79
1.4
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
21
148
1.43
0.78
1.1
1.1
3.73
2.28
u/ml
—
10
80
6
34
1.77
0.76
1.0
1.2
—
—
—
0
0
9
53
1.70
0.75
1.4
1.5
—
—
—
0
0
9
57
1.58
0.71
1.0
1.1
—
—
—
0
0
89
770
1.17
0.70
1.7
1.8
—
—
—
0
0
9
59
1.53
0.68
1.4
1.6
—
—
—
0
0
30
231
1.31
0.68
1.5
1.3
—
—
—
0
0
28
214
1.32
0.67
1.6
1.7
9385.45
13557.07
e6/l
0.40
20
160
11
167
0.66
0.66
1.6
1.4
—
—
—
0
0
18
248
0.72
0.66
1.7
1.6
—
—
—
0
0
18
128
1.41
0.66
2.9
2.9
13.26
13.21
%
0.09
18
128
378
3578
1.09
0.65
4.6
4.2
2.00
2.23
ug/l
0.49
342
3257
12
79
1.52
0.62
4.8
2.5
—
—
—
0
0
8
50
1.60
0.61
1.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
17
122
1.40
0.60
1.3
1.6
—
—
—
0
0
6
36
1.67
0.56
1.3
1.0
—
—
—
0
0
19
142
1.34
0.54
1.1
1.1
—
—
—
0
0
785
7680
1.08
0.54
19.6
15.2
14.82
14.80
%
0.03
774
7539
6
38
1.58
0.54
1.0
1.3
—
54.00
—
0
5
6
98
0.61
0.52
1.5
1.5
—
—
—
0
0
14
100
1.41
0.52
1.4
1.7
—
—
—
0
0
14
100
1.41
0.52
1.4
1.7
—
—
—
0
0
11
75
1.47
0.50
1.4
2.2
3.86
5.52
umol/l
—
5
51
6
41
1.47
0.50
1.0
1.1
—
—
—
0
0
19
145
1.32
0.49
1.2
1.2
23.52
33.06
u/l
0.34
14
125
7
45
1.56
0.49
2.1
2.8
158.29
210.58
u/l
—
7
45
916
9032
1.10
0.49
5.2
4.8
2.76
2.80
mmol/l
0.76
833
8397
255
2406
1.08
0.48
1.8
1.7
1.48
1.44
mmol/l
0.24
212
2034
21
164
1.29
0.47
1.2
1.5
103.81
129.93
u/ml
—
8
30
20
156
1.29
0.45
1.4
1.5
—
—
—
0
0
43
368
1.18
0.43
1.6
2.7
40.10
54.71
u/ml
0.32
43
354
5
31
1.62
0.43
2.0
2.0
—
—
—
0
0
8
58
1.38
0.41
1.4
1.2
—
—
—
0
0
5
33
1.52
0.41
2.0
1.4
9.41
8.81
ug/l
—
5
33
0
16
0.00
0.41
0.0
2.9
—
9.00
—
0
7
30
250
1.21
0.40
1.2
1.2
—
—
—
0
0
10
138
0.72
0.40
1.7
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
45.69
—
0
18
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
30
252
1.20
0.38
1.2
1.2
—
—
—
0
0
94
859
1.10
0.38
1.8
1.9
—
—
—
0
0
5
37
1.35
0.37
1.6
1.1
153.96
233.01
iu/ml
—
5
37
8
116
0.69
0.37
1.1
1.8
—
—
—
0
0
9
125
0.72
0.35
1.7
1.4
—
—
—
0
0
9
125
0.72
0.35
1.7
1.4
—
—
—
0
0
9
125
0.72
0.35
1.7
1.4
—
—
—
0
0
9
125
0.72
0.35
1.7
1.4
—
—
—
0
0
6
44
1.37
0.34
2.3
2.8
1237.50
1342.14
u/ml
—
6
44
6
44
1.37
0.34
1.7
2.5
28623.17
38206.82
ug/l
—
6
44
865
8547
1.06
0.32
4.4
3.9
1.39
1.34
mmol/l
0.76
787
7909
37
323
1.15
0.32
3.5
3.3
47.87
1311.99
u/ml
1.41
30
272
898
8888
1.06
0.30
4.9
4.4
4.63
4.68
mmol/l
0.91
830
8316
16
130
1.23
0.29
1.3
1.2
—
—
—
0
0
223
2141
1.05
0.26
2.9
2.7
0.68
0.70
ug/l
0.10
133
1306
23
197
1.17
0.26
1.4
1.9
3.91
4.96
iu/l
—
5
64
20
169
1.19
0.26
1.1
1.2
382.60
259.38
u/ml
0.58
15
102
27
237
1.14
0.23
1.3
1.4
—
—
—
0
0
299
2905
1.04
0.22
3.7
3.7
20.76
21.16
%
0.15
134
1279
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.97
—
0
8
0
14
0.00
0.20
0.0
1.1
—
0.59
—
0
9
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
27.78
—
0
9
6
48
1.25
0.20
1.7
1.3
—
—
—
0
0
6
52
1.15
0.19
2.0
3.8
—
—
—
0
0
891
8847
1.04
0.18
4.9
4.3
1.39
1.43
mmol/l
2.10
816
8235
12
101
1.19
0.16
1.4
1.3
0.88
0.60
nmol/l
0.74
12
93
25
225
1.11
0.16
1.4
1.4
—
—
—
0
0
6
76
0.79
0.15
1.0
1.0
—
—
—
0
0
20
178
1.13
0.15
1.2
1.2
—
—
—
0
0
10
84
1.19
0.14
1.5
1.5
—
—
—
0
0
44
416
1.06
0.11
1.7
1.8
—
—
—
0
0
23
212
1.09
0.10
2.3
2.2
14.29
123.77
ug/min
1.81
15
123
5
46
1.09
0.09
1.4
1.3
—
—
—
0
0
10
87
1.15
0.09
1.0
1.2
—
—
—
0
0
6
57
1.05
0.08
1.7
1.5
—
—
—
0
0
12
107
1.12
0.08
1.1
1.1
105.67
99.38
%
0.29
12
101
11
123
0.89
0.08
1.0
1.1
—
—
—
0
0
17
156
1.09
0.08
1.9
1.6
—
—
—
0
0
12
108
1.11
0.07
2.2
1.4
0.22
0.25
nmol/l
0.21
12
87
7
81
0.86
0.07
1.0
1.1
—
—
—
0
0
17
158
1.08
0.06
2.6
1.5
—
—
—
0
0
15
140
1.07
0.04
1.4
1.2
13.14
4.95
u/ml
—
7
58
106
1076
0.98
0.04
1.5
1.4
—
—
—
0
0
21
202
1.04
0.02
1.3
1.2
—
—
—
0
0
95
959
0.99
0.01
1.5
1.8
—
—
—
0
0
34
344
0.99
0.00
1.6
1.7
—
—
—
0
0
23
232
0.99
0.00
1.3
1.4
105.51
240.78
miu/ml
2.19
11
107
13
127
1.02
0.00
1.0
1.1
1.51
1.48
g/l
0.13
13
116
10
95
1.05
0.00
2.3
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
5
58
0.86
0.00
1.8
1.4
6.62
6.65
u/l
—
5
45
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.47
—
0
6
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.2
—
—
—
0
0
7
77
0.91
-0.00
2.4
3.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.9
—
51.23
—
0
9
0
6
0.00
-0.00
0.0
7.3
—
412.33
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.434 [1.18, 1.74] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.203 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 1536 females with M13_BONEDISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.396 [1.14, 1.7] | 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 1231 males with M13_BONEDISNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.265% |
| 5 | 0.864% | 1.517% |
| 10 | 2.15% | 3.733% |
| 15 | 3.897% | 7.014% |
| 20 | 7.024% | 12.433% |
Relationships between endpoints
↥Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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