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Other specified/unspecified disorders of bone/cartilage

DOID EFO Endpoint Browser PheWeb

M13_BONEDISNAS

cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

1052

4. Check minimum number of events

None

1052

5. Include endpoints

None

1052

6. Filter based on genotype QC (FinnGen only)

1052

Control definitions (FinnGen only)

Control exclude
M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8627 3501 5069
Only index persons 7527 3030 4497
Unadjusted period prevalence (%)
Whole population 0.12 0.10 0.14
Only index persons 0.15 0.11 0.17
Median age at first event (years)
Whole population 30.25 43.37 20.93
Only index persons 28.79 40.76 20.73

-FinnGen-

Key figures

All Female Male
Number of individuals 1052 476 576
Unadjusted period prevalence (%) 0.21 0.16 0.25
Median age at first event (years) 32.17 42.28 23.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
953
Matched controls
9530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
72398
ICD-8 Finland
Other diseases of bone, Alii definiti
+∞
323.0
326
*
M89.9
ICD-10 Finland
Disorder of bone, unspecified
+∞
147.8
138
*
M94.9
ICD-10 Finland
Disorder of cartilage, unspecified
556.1
147.8
143
*
72399
ICD-8 Finland
Other diseases of bone
+∞
103.0
97
*
M94.8
ICD-10 Finland
Other specified disorders of cartilage
358.7
96.8
96
*
7339X
ICD-9 Finland
Other disorders of bone and cartilage, Other and unspecified disorders of bone and cartilage
+∞
95.4
90
*
M89.88
ICD-10 Finland
Other specified disorders of bone, other
+∞
64.3
61
*
9102
FHL
Trepanation or removal of the local bone process
28.7
32.7
44
16
M89.0
ICD-10 Finland
Algoneurodystrophy
+∞
29.3
28
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.7
23.2
108
320
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
21.3
21.3
31
15
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
5.3
21.0
65
129
M25.5
ICD-10 Finland
Pain in joint
2.1
20.1
286
1616
N02AX02
ATC
tramadol; systemic, rectal
1.9
18.5
414
2766
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.6
18.4
147
624
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.1
15.7
205
1100
M54.5
ICD-10 Finland
Low back pain
1.8
14.6
302
1925
N03AX16
ATC
pregabalin; oral
1.9
13.8
229
1348
M03BX02
ATC
tizanidine; oral
1.7
13.6
581
4578
N06AX21
ATC
duloxetine; oral
2.5
13.4
110
473
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
13.1
111
487
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.2
12.8
144
723
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
12.4
255
1605
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.3
12.4
29
41
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.4
12.2
112
510
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.4
12.0
108
486
M01AH05
ATC
etoricoxib; oral
1.6
11.9
558
4427
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
11.8
256
1638
R51.80
ICD-10 Finland
Headache
2.1
11.5
135
691
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
5.1
11.2
34
68
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
11.0
82
333
M02AA07
ATC
piroxicam; topical
1.6
10.7
327
2300
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
7.1
10.6
25
36
1220
FHL
Arthroscopy
3.2
10.5
54
175
M79.6
ICD-10 Finland
Pain in limb
1.7
10.5
302
2088
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
10.4
152
844
9476
FHL
Splitting of fascia or aponeurosis
8.9
10.3
21
24
N03AX12
ATC
gabapentin; oral
1.9
9.9
145
807
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
9.9
93
429
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.8
426
3254
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
9.7
343
2486
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
9.7
98
467
M01AB05
ATC
diclofenac; systemic, rectal
1.5
9.3
614
5141
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.2
361
2677
N06AX16
ATC
venlafaxine; oral
1.9
8.8
125
687
A03FA02
ATC
cisapride; oral, rectal
2.4
8.8
72
311
J01FF01
ATC
clindamycin; systemic
1.6
8.7
243
1652
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.7
288
2046
R03DC03
ATC
montelukast; oral
1.9
8.6
141
816
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
5.4
8.5
24
45
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.2
8.4
90
440
M89.81
ICD-10 Finland
Other specified disorders of bone, shoulder region
+∞
8.3
8
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
8.3
233
1583
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.1
8.3
93
464
M01AH01
ATC
celecoxib; oral (coxibs)
1.8
8.2
163
1001
J01AA02
ATC
doxycycline; systemic
1.5
8.2
700
6112
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.6
8.2
57
226
M23.8
ICD-10 Finland
Other internal derangements of knee
3.0
8.2
44
149
N06AA09
ATC
amitriptyline; systemic
2.1
8.1
88
434
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
8.1
332
2472
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.2
8.1
85
412
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
8.1
152
919
M01AE02
ATC
naproxen; oral, rectal
1.5
8.0
499
4061
A02BC01
ATC
omeprazole; systemic
1.6
8.0
232
1587
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.9
177
1129
9101
FHL
Bone biopsy
45.3
7.7
9
*
H02AB06
ATC
prednisolone; systemic
1.5
7.7
401
3132
WX002
NOMESCO Finland
Sedation and analgesia
1.7
7.7
169
1073
T92.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of upper limb
8.9
7.6
15
17
R05FB02
ATC
cough suppressants and expectorants
1.5
7.5
314
2338
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
7.4
206
1390
SPAT1312
SPAT
General health counselling
1.6
7.4
252
1790
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
80.7
7.4
8
*
M01AX05
ATC
glucosamine; oral
1.7
7.3
161
1017
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.4
7.3
58
248
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
7.3
7
*
M94.2
ICD-10 Finland
Chondromalacia
30.2
7.2
9
*
N02AA05
ATC
oxycodone; systemic
1.9
7.1
110
621
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
5.1
7.1
21
42
R96
ICPC
Asthma
2.1
7.1
76
373
A02BA02
ATC
ranitidine; systemic
1.7
7.0
167
1085
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
7.0
223
1559
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
6.9
137
840
M01AC06
ATC
meloxicam; systemic, rectal
1.5
6.8
310
2341
Y0899
ICD-8 Finland
Investigation of musculoskeletal system
9.4
6.8
13
14
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.1
6.8
78
393
B01AB05
ATC
enoxaparin; parenteral
1.5
6.6
248
1794
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
6.6
79
406
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
6.6
89
481
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.5
161
1052
UKC02
NOMESCO Finland
Cystoscopy
1.8
6.5
122
736
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
70.3
6.4
7
*
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
4.9
6.4
19
39
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
4.2
6.3
22
53
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.8
6.3
112
665
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
9.3
6.3
12
13
R03AC02
ATC
salbutamol; inhalant
1.4
6.3
436
3564
M84.8
ICD-10 Finland
Other disorders of continuity of bone
+∞
6.3
6
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
6.3
85
462
WX320
NOMESCO Finland
Spinalanesthesy
1.6
6.2
179
1218
M01AE01
ATC
ibuprofen; systemic, rectal
1.6
6.1
820
7577
X58
ICD-10 Finland
Exposure to other specified factors
1.7
6.1
125
772
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.1
534
4536
J01DB01
ATC
cefalexin; oral
1.5
6.1
725
6523
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.9
6.0
92
517
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
6.0
236
1721

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
448
3289
1.63
13.04
7.8
8.3
1.3
1.2
inr
0.66
128
959
765
6420
1.70
12.93
8.2
7.3
76.7
77.2
u/l
0.10
718
6038
471
3526
1.61
12.50
7.7
5.8
1.2
1.2
mmol/l
0.33
431
3207
455
3396
1.60
12.11
4.9
4.8
35.9
35.9
g/l
0.00
430
3170
539
4240
1.56
11.08
6.1
6.2
10.9
11.5
umol/l
0.66
520
4022
541
4267
1.55
10.94
6.2
6.1
0.2
0.2
e9/l
0.26
475
3765
359
2586
1.59
10.80
2.7
2.5
58.3
57.7
u/l
0.06
334
2402
428
3244
1.54
10.12
2.7
2.1
76.7
75.6
nmol/l
0.34
383
2919
495
3877
1.52
10.02
8.9
6.5
1.2
1.2
mmol/l
0.31
422
3303
530
4229
1.51
9.71
6.0
5.8
2.2
2.0
e9/l
0.28
472
3741
517
4107
1.51
9.66
6.0
5.8
0.6
0.6
e9/l
0.83
453
3575
519
4127
1.51
9.64
6.0
5.8
0.0
0.0
e9/l
0.23
454
3587
307
2180
1.58
9.61
3.3
2.9
—
—
—
0
0
300
2132
1.57
9.31
4.6
4.1
—
—
—
0
0
177
1105
1.72
9.18
1.3
1.3
391.8
500.8
titre
0.50
34
221
164
1007
1.74
9.02
5.9
5.9
1.0
1.0
mmol/l
0.42
156
939
722
6195
1.53
9.01
4.8
3.9
11.4
11.1
mm/h
0.29
682
5739
365
2744
1.51
8.63
5.9
5.7
—
—
—
0
0
232
1577
1.60
8.62
1.6
1.4
2.4
2.5
g/l
0.78
148
1000
414
3196
1.49
8.58
4.6
3.3
29.7
56.9
ng/l
1.20
303
2190
180
1153
1.68
8.46
2.8
2.3
2.3
2.4
g/l
1.39
171
1083
170
1074
1.70
8.41
2.9
2.4
23.7
23.3
%
0.16
150
928
94
498
1.97
8.24
2.5
2.3
—
—
—
0
0
189
1245
1.63
7.94
2.8
2.3
13.7
13.5
umol/l
0.15
177
1164
53
228
2.39
7.83
3.0
3.3
27.1
33.6
mg/l
0.89
47
180
481
3875
1.44
7.77
6.6
6.2
8.5
8.7
%
1.11
453
3651
308
2281
1.50
7.66
4.7
3.9
7.4
7.4
ph
0.28
58
435
52
224
2.39
7.66
3.0
3.2
2.8
2.0
ratio
—
5
19
485
3927
1.44
7.55
5.9
5.8
57.1
56.9
%
0.15
458
3698
490
3976
1.44
7.54
6.2
6.0
28.0
28.1
%
0.11
460
3726
52
228
2.35
7.37
3.1
3.3
39.7
73.7
mg/l
0.64
46
181
105
600
1.83
7.33
2.5
2.7
66.7
66.9
g/l
0.07
96
562
587
4938
1.43
7.30
5.5
4.6
6.7
6.7
mmol/l
0.01
560
4610
621
5285
1.43
7.19
5.1
4.0
1701.8
2583.2
e6/l
—
6
85
473
3847
1.42
7.02
3.9
3.9
—
—
—
0
0
473
3853
1.41
6.92
6.2
5.9
2.9
2.9
%
0.25
445
3603
460
3737
1.41
6.80
6.2
5.9
0.7
0.7
%
0.60
432
3503
566
4770
1.40
6.74
8.4
9.1
4.1
4.1
e9/l
0.02
506
4188
143
917
1.65
6.63
1.3
1.3
—
—
—
0
0
121
743
1.71
6.61
5.7
4.0
—
—
—
0
0
655
5675
1.41
6.55
4.9
3.9
—
—
—
0
0
227
1638
1.49
6.26
2.6
2.5
6.6
5.3
e6/l
0.51
193
1441
188
1311
1.53
6.09
3.5
3.5
0.8
0.8
mmol/l
0.21
173
1241
10
16
6.30
5.96
2.0
2.1
90.6
60.2
ug/l
—
10
16
311
2406
1.42
5.90
4.9
3.6
—
—
—
0
0
63
328
1.98
5.85
1.7
2.0
1.5
1.6
g/l
0.63
52
289
923
8600
1.60
5.82
17.0
12.7
21.2
23.6
mg/l
1.54
769
6755
296
2276
1.42
5.79
2.8
2.5
2390.8
5948.7
umol/l
0.93
262
2005
309
2400
1.41
5.70
3.8
3.1
29.7
91.4
e6/l
1.44
242
1843
92
546
1.75
5.68
4.7
3.7
78.9
83.1
ng/l
0.20
74
489
210
1522
1.47
5.62
3.2
2.7
543.6
567.8
mosm/kgh2o
0.86
177
1316
284
2179
1.42
5.60
3.5
3.0
0.4
0.5
e6/l
0.23
218
1627
149
1005
1.56
5.59
2.7
2.4
126.4
138.2
ug/g
0.18
111
810
128
833
1.61
5.59
2.3
2.5
1.8
1.8
%
0.17
110
754
38
168
2.31
5.35
3.3
3.6
—
—
—
0
0
315
2480
1.39
5.30
2.3
2.1
259.2
224.2
u/l
0.12
297
2338
22
74
3.02
5.28
1.7
2.6
—
—
—
0
0
86
513
1.74
5.23
1.9
1.6
1.2
1.5
g/l
1.21
75
473
270
2076
1.40
5.21
4.3
3.7
91.9
91.4
%
0.13
261
2033
98
612
1.66
5.05
2.1
2.6
67.1
72.7
e9/l
1.09
77
478
105
668
1.64
5.03
10.8
8.1
—
—
—
0
0
101
637
1.65
5.01
2.5
2.4
10.0
10.6
g/l
0.80
92
588
390
3202
1.35
4.97
2.2
2.0
—
—
—
0
0
245
1870
1.40
4.91
1.7
1.7
1.3
1.1
mg/l
0.38
188
1430
95
593
1.66
4.90
1.3
1.5
—
—
—
0
0
193
1411
1.45
4.90
1.3
1.3
20.9
34.4
iu/ml
1.37
59
460
65
368
1.82
4.73
4.8
3.7
23.5
24.4
mmol/l
1.34
59
337
273
2138
1.37
4.66
3.5
2.9
—
—
—
0
0
316
2533
1.35
4.65
2.5
2.3
—
—
—
0
0
37
174
2.17
4.55
1.2
1.3
249.3
1213.3
e6/l
0.66
28
138
37
174
2.17
4.55
1.2
1.2
6.8
6.6
e6/l
0.02
28
132
110
726
1.58
4.54
2.2
2.1
361.1
367.9
nmol/l
0.15
101
670
249
1929
1.38
4.53
2.4
2.2
—
—
—
0
0
323
2610
1.34
4.48
3.1
3.3
2.3
2.4
mmol/l
0.41
274
2303
142
997
1.49
4.42
1.4
1.4
—
—
—
0
0
258
2021
1.37
4.37
6.9
6.6
—
—
—
0
0
159
1155
1.44
4.16
2.1
2.0
—
—
—
0
0
235
1827
1.37
4.15
1.7
1.5
20.9
20.9
nmol/l
0.01
189
1575
48
258
1.90
4.14
1.4
1.5
280.7
278.2
ug/g
0.03
32
154
41
209
2.00
4.11
1.2
1.2
4.7
2.6
u/ml
—
6
22
171
1262
1.42
4.11
1.9
1.9
30.1
29.6
s
0.31
163
1222
65
386
1.73
4.06
2.4
2.3
—
—
—
0
0
286
2301
1.33
4.03
3.1
2.8
987.2
1135.7
ng/l
0.38
241
1939
108
733
1.53
3.96
4.9
3.6
1.1
2.1
mmol/l
1.51
91
586
831
7730
1.36
3.93
5.2
4.4
1.9
2.1
mu/l
0.62
750
7097
381
3200
1.30
3.92
2.2
1.9
98.1
94.4
pmol/l
0.76
191
1707
33
159
2.11
3.85
1.1
1.3
—
—
—
0
0
224
1748
1.36
3.85
1.3
1.3
0.8
1.4
u/ml
1.18
56
483
337
2798
1.30
3.75
4.6
3.5
133.7
92.0
e6/l
0.24
255
1990
93
619
1.55
3.73
3.8
2.8
4.7
4.6
kpa
0.14
88
599
81
522
1.60
3.73
3.8
3.1
7.4
7.4
ph
0.33
12
72
10
25
4.03
3.70
1.0
1.2
—
—
—
0
0
323
2671
1.30
3.69
3.4
3.0
8.0
8.1
mmol/l
0.04
262
2258
31
151
2.08
3.54
1.6
1.6
—
—
—
0
0
35
179
1.99
3.52
3.0
3.9
—
—
—
0
0
233
1859
1.33
3.42
4.5
3.2
—
—
—
0
0
129
935
1.43
3.42
2.1
1.6
—
—
—
0
0
404
3468
1.27
3.38
3.3
2.7
138.7
143.6
ug/l
0.16
373
3204
933
8899
1.43
3.33
19.8
14.5
139.5
139.7
mmol/l
1.16
913
8669
28
135
2.10
3.30
2.4
3.8
—
—
—
0
0
15
54
2.80
3.26
1.0
1.0
910.6
670.5
ng/l
—
10
33
15
54
2.80
3.26
1.0
1.0
291.5
237.4
ng/l
—
10
34
105
739
1.47
3.26
2.1
2.3
0.2
0.2
g/l
0.66
98
706
52
311
1.71
3.22
1.7
1.9
23.6
21.3
s
1.02
44
278
180
1396
1.35
3.20
1.8
1.7
1141.5
1181.2
nmol/l
0.25
126
1055
82
551
1.53
3.18
2.6
3.1
4.2
4.1
e9/l
0.06
56
435
34
180
1.92
3.13
1.4
1.4
—
—
—
0
0
853
8042
1.32
3.11
6.2
5.5
39.9
39.8
mmol/mol
0.09
775
7524
123
904
1.41
3.03
2.4
2.8
6.1
8.6
umol/l
1.56
106
783
934
8938
1.40
3.00
19.8
14.6
4.0
4.0
mmol/l
0.50
913
8697
946
9080
1.42
2.92
16.3
12.2
—
—
—
0
0
21
95
2.24
2.91
2.1
2.6
—
—
—
0
0
58
370
1.60
2.84
4.3
3.0
—
—
—
0
0
116
858
1.40
2.77
3.0
2.2
13.3
13.5
nmol/l
0.13
104
779
297
2511
1.25
2.73
3.6
3.2
767.7
309.7
mg/l
0.58
180
1616
39
227
1.75
2.70
1.7
1.9
37.8
37.7
g/l
0.03
33
198
173
1368
1.32
2.69
1.3
1.2
2.7
10.6
u/ml
3.69
60
540
148
1145
1.34
2.68
1.3
1.2
—
—
—
0
0
234
1928
1.27
2.66
4.1
4.5
—
—
—
0
0
961
9273
1.42
2.64
11.9
9.8
28.2
27.9
u/l
0.16
935
8973
96
701
1.41
2.49
2.4
2.3
6.0
7.5
ug/l
0.44
73
627
59
391
1.54
2.49
3.3
2.5
0.6
0.7
%
0.46
59
376
461
4118
1.21
2.46
4.5
3.3
0.0
0.0
estimate
0.80
98
729
12
45
2.69
2.45
1.1
1.1
—
—
—
0
0
308
2646
1.23
2.41
4.2
3.9
15.3
8.1
mg/mmol
0.56
196
1707
261
2203
1.25
2.40
4.9
3.6
0.0
0.0
estimate
0.69
96
754
88
637
1.42
2.40
3.9
4.6
0.1
0.2
%
0.25
26
184
681
6329
1.22
2.37
4.4
3.7
14.8
14.7
pmol/l
0.27
614
5761
83
596
1.43
2.37
3.6
4.7
0.0
0.7
%
0.57
23
153
37
221
1.70
2.37
2.9
3.0
—
—
—
0
0
38
229
1.68
2.36
1.5
1.4
6.8
9.1
u/l
0.89
29
188
49
317
1.57
2.31
4.0
3.3
24.5
24.9
mmol/l
0.35
49
302
91
668
1.40
2.30
4.2
3.2
—
—
—
0
0
84
611
1.41
2.25
3.8
4.3
0.6
0.4
%
0.42
22
145
419
3734
1.20
2.24
11.1
9.0
0.0
0.0
e9/l
0.28
351
3084
18
86
2.11
2.23
1.2
1.2
—
—
—
0
0
30
172
1.77
2.22
3.3
3.1
—
—
—
0
0
229
1924
1.24
2.19
2.6
2.1
2.8
3.0
mg/l
0.74
191
1641
91
679
1.37
2.11
3.8
4.5
0.7
0.9
%
0.40
28
207
17
82
2.09
2.07
1.3
1.3
8469.7
228304.5
e6/l
—
10
59
29
170
1.73
2.02
2.4
2.7
16.3
16.7
%
0.20
18
92
451
4080
1.18
1.98
5.8
4.5
0.0
0.0
estimate
0.00
101
781
14
65
2.17
1.88
2.0
1.8
546.0
708.0
e6/l
—
5
20
45
301
1.52
1.88
1.6
2.6
—
—
—
0
0
187
1563
1.24
1.87
4.3
3.7
327.7
414.6
ng/l
0.19
131
1206
16
79
2.04
1.86
1.5
1.3
—
—
—
0
0
199
1681
1.23
1.81
1.8
1.7
39130849.1
33570838.8
pmol/l
0.05
161
1406
9
35
2.58
1.80
1.2
1.3
138.1
154.1
nmol/l
—
9
35
6
18
3.35
1.75
1.0
1.2
1.6
2.0
mmol/l
—
6
18
68
501
1.38
1.74
4.1
3.0
130.8
130.8
g/l
0.00
68
496
18
96
1.89
1.71
1.2
1.1
—
—
—
0
0
79
599
1.34
1.69
1.2
1.2
—
—
—
0
0
445
4061
1.17
1.68
4.5
3.3
0.0
0.0
estimate
0.00
95
757
14
69
2.04
1.65
3.5
3.2
—
—
—
0
0
29
181
1.62
1.64
3.2
2.4
132.0
133.2
g/l
0.10
22
141
69
515
1.36
1.64
5.1
5.9
—
—
—
0
0
152
1261
1.24
1.64
4.1
2.8
2.7
2.3
e6/l
0.14
86
683
47
330
1.44
1.59
5.2
4.6
—
—
—
0
0
113
910
1.27
1.58
10.2
7.9
0.1
1.0
mmol/l
1.63
94
730
17
92
1.86
1.56
4.4
7.0
11.6
11.3
mg/l
0.11
17
85
6
21
2.87
1.50
1.0
1.5
—
—
—
0
0
38
259
1.48
1.50
2.7
3.7
0.4
0.3
g/l
0.39
15
109
88
692
1.30
1.49
1.6
1.4
—
—
—
0
0
14
72
1.96
1.49
1.2
1.1
—
—
—
0
0
10
45
2.23
1.46
1.4
1.2
—
—
—
0
0
62
465
1.35
1.46
3.7
3.2
4.4
4.6
pmol/l
0.79
56
403
16
88
1.83
1.42
2.6
2.4
—
—
—
0
0
644
6090
1.15
1.40
4.1
3.6
—
—
—
0
0
7
29
2.42
1.39
4.4
2.1
—
—
—
0
0
13
67
1.95
1.38
1.9
1.8
1.3
1.0
e9/l
—
6
40
15
82
1.84
1.36
4.1
3.7
—
—
—
0
0
15
82
1.84
1.36
1.1
1.3
—
—
—
0
0
10
47
2.14
1.34
1.2
1.1
—
—
—
0
0
12
61
1.98
1.33
1.2
1.2
—
—
—
0
0
205
1791
1.18
1.31
4.9
3.4
1.0
1.0
kg/l
0.76
21
243
6
24
2.51
1.30
1.0
1.9
—
—
—
0
0
18
106
1.71
1.30
1.4
1.6
74.8
60.9
%
—
10
72
135
1138
1.21
1.28
1.5
1.6
—
—
—
0
0
12
62
1.95
1.28
1.4
1.5
—
—
—
0
0
9
44
2.05
1.27
1.8
1.5
—
—
—
0
0
75
592
1.29
1.26
2.2
2.9
137.0
183.8
ng/l
0.60
70
532
66
513
1.31
1.25
1.1
1.2
126.1
140.3
iu/ml
0.08
23
202
20
123
1.64
1.24
1.3
1.3
47.2
61.4
mmol/l
1.60
12
105
6
25
2.41
1.24
1.2
1.7
—
—
—
0
0
100
820
1.24
1.24
3.8
4.2
12.4
15.9
ug/l
0.16
82
672
160
1378
1.19
1.22
1.6
1.8
—
—
—
0
0
95
777
1.24
1.21
1.3
1.3
—
—
—
0
0
16
94
1.71
1.18
1.4
2.2
34.3
33.3
pg
0.47
16
94
161
1395
1.18
1.15
3.0
3.1
2.4
2.4
mmol/l
0.15
137
1223
44
327
1.36
1.14
1.3
1.2
—
—
—
0
0
111
930
1.22
1.14
1.5
1.6
—
—
—
0
0
24
159
1.52
1.12
3.0
2.5
—
—
—
0
0
55
424
1.31
1.12
15.9
11.0
—
—
—
0
0
47
354
1.34
1.12
2.3
1.6
—
—
—
0
0
21
135
1.57
1.12
1.2
1.2
—
—
—
0
0
10
51
1.97
1.11
3.4
3.4
—
—
—
0
0
12
66
1.83
1.09
1.5
1.8
16.9
20.8
nmol/l
1.26
12
61
7
32
2.20
1.08
1.0
1.0
—
—
—
0
0
13
74
1.77
1.07
1.6
1.7
—
—
—
0
0
23
153
1.51
1.07
1.6
1.7
—
—
—
0
0
39
288
1.37
1.06
1.8
1.7
—
—
—
0
0
15
90
1.68
1.04
3.1
2.4
—
—
—
0
0
5
22
2.28
1.03
2.2
1.7
—
—
—
0
0
28
196
1.44
1.03
3.0
2.4
7.9
8.2
kpa
0.47
28
182
9
47
1.92
1.02
1.3
1.3
—
—
—
0
0
59
467
1.28
1.01
1.3
1.2
—
—
—
0
0
7
36
1.95
0.97
6.7
2.8
—
—
—
0
0
12
69
1.75
0.96
1.1
1.1
—
—
—
0
0
42
320
1.33
0.96
1.1
1.1
—
—
—
0
0
25
174
1.45
0.96
4.1
5.0
2.4
2.5
mmol/l
0.06
15
115
865
8430
1.15
0.95
4.9
4.4
6.1
6.0
mmol/l
0.85
779
7757
30
218
1.39
0.92
1.1
1.4
—
—
—
0
0
22
151
1.47
0.91
1.2
1.2
—
—
—
0
0
984
9697
1.23
0.89
24.8
18.9
250.0
247.5
e9/l
0.59
967
9450
21
144
1.47
0.87
1.1
1.1
0.7
2.1
u/ml
—
6
62
21
144
1.47
0.87
1.2
1.1
1.0
36.7
iu/ml
—
6
30
19
128
1.49
0.86
1.1
1.0
6.9
6.6
u/ml
—
10
64
824
8021
1.13
0.86
17.3
13.6
40.8
40.7
%
0.25
593
5978
984
9701
1.22
0.85
24.7
18.8
30.5
30.4
pg
0.70
972
9562
984
9701
1.22
0.85
24.7
18.8
91.2
90.9
fl
0.84
972
9564
6
31
1.94
0.84
7.7
3.0
—
—
—
0
0
984
9703
1.22
0.84
24.8
18.9
4.5
4.6
e12/l
1.45
964
9438
22
154
1.44
0.84
1.6
1.3
—
—
—
0
0
53
427
1.25
0.82
1.1
1.1
—
—
—
0
0
984
9706
1.21
0.81
24.8
18.9
6.8
6.7
e9/l
0.73
964
9438
82
694
1.20
0.80
4.0
3.7
—
—
—
0
0
984
9707
1.21
0.80
24.9
19.0
136.9
138.0
g/l
1.41
972
9569
28
207
1.36
0.80
1.5
1.7
9855.6
13848.8
e6/l
0.36
19
155
8
48
1.67
0.79
2.3
2.0
—
—
—
0
0
18
123
1.47
0.78
1.1
1.0
1.3
0.8
u/ml
—
8
48
18
123
1.47
0.78
1.4
1.2
—
—
—
0
0
17
115
1.49
0.77
1.2
1.6
—
—
—
0
0
13
83
1.57
0.75
1.5
1.4
17.3
28.3
%
—
7
54
5
24
2.09
0.74
1.2
2.3
—
—
—
0
0
29
219
1.33
0.74
2.0
2.3
1688.5
3337.6
u/l
0.40
13
84
18
125
1.45
0.73
2.9
2.9
13.3
13.2
%
0.11
18
125
5
25
2.00
0.72
1.0
1.3
—
—
—
0
0
115
1012
1.15
0.72
19.2
22.5
1.3
1.3
inr
0.11
12
142
7
39
1.80
0.72
1.0
1.6
—
—
—
0
0
15
101
1.49
0.70
1.0
1.2
—
—
—
0
0
73
621
1.19
0.70
5.2
3.8
1.2
1.2
mmol/l
0.51
67
543
9
59
1.53
0.68
1.6
1.3
—
—
—
0
0
5
28
1.79
0.66
1.4
5.5
—
—
—
0
0
10
62
1.62
0.65
1.5
1.3
—
—
—
0
0
22
163
1.36
0.64
2.9
1.8
—
—
—
0
0
5
29
1.73
0.64
2.6
17.4
—
—
—
0
0
36
288
1.26
0.63
1.0
1.1
—
—
—
0
0
47
388
1.22
0.63
1.0
1.1
—
76.6
—
0
7
375
3555
1.09
0.62
4.6
4.2
2.0
2.2
ug/l
0.34
339
3240
102
904
1.14
0.60
1.5
1.5
—
—
—
0
0
32
254
1.27
0.60
1.3
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
0.8
—
0
11
18
131
1.38
0.59
1.6
1.4
—
—
—
0
0
11
72
1.53
0.59
1.4
2.2
3.9
5.5
umol/l
—
5
49
24
184
1.31
0.58
1.3
1.7
—
—
—
0
0
244
2281
1.09
0.56
3.7
3.1
—
—
—
0
0
67
580
1.17
0.55
1.4
1.5
—
—
—
0
0
14
99
1.42
0.54
1.4
1.7
—
—
—
0
0
14
99
1.42
0.54
1.4
1.7
—
—
—
0
0
14
99
1.42
0.54
1.4
1.7
—
—
—
0
0
14
99
1.42
0.54
1.4
1.7
—
—
—
0
0
6
40
1.50
0.51
1.0
1.1
—
534.7
—
0
9
13
180
0.72
0.51
1.4
1.3
—
—
—
0
0
42
352
1.20
0.51
1.6
2.7
40.4
55.9
u/ml
0.33
42
338
21
162
1.30
0.50
1.2
1.5
103.8
130.0
u/ml
—
8
29
29
234
1.25
0.50
1.1
1.2
—
1211.3
—
0
8
14
101
1.39
0.49
4.1
2.8
—
—
—
0
0
34
282
1.21
0.46
12.2
8.7
—
—
—
0
0
742
7272
1.07
0.44
19.7
15.6
13.7
13.6
%
1.08
725
7119
11
78
1.41
0.43
3.2
1.9
—
—
—
0
0
8
56
1.43
0.42
1.3
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
7.1
—
0
7
0
16
0.00
0.41
0.0
1.0
—
30.1
—
0
7
0
18
0.00
0.40
0.0
8.3
—
—
—
0
0
5
35
1.43
0.39
1.6
1.1
154.0
243.2
iu/ml
—
5
35
37
317
1.17
0.38
3.5
3.3
48.0
1325.3
u/ml
1.41
30
269
22
179
1.23
0.37
1.4
1.5
—
—
—
0
0
896
8856
1.08
0.37
5.2
4.8
2.7
2.8
mmol/l
0.86
815
8229
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
247
2355
1.06
0.36
1.8
1.7
1.5
1.4
mmol/l
0.28
208
1990
6
42
1.43
0.35
2.3
2.8
1237.5
1380.6
u/ml
—
6
42
9
124
0.72
0.35
1.1
1.2
—
—
—
0
0
11
82
1.35
0.34
1.0
1.1
—
—
—
0
0
12
91
1.32
0.34
1.3
1.2
—
—
—
0
0
17
137
1.24
0.32
1.3
1.7
—
—
—
0
0
12
154
0.78
0.32
1.2
1.1
—
—
—
0
0
12
154
0.78
0.32
1.2
1.1
—
—
—
0
0
32
276
1.16
0.32
1.3
1.4
—
—
—
0
0
19
230
0.82
0.31
1.2
1.4
118.5
240.9
miu/ml
—
9
107
32
277
1.16
0.31
1.3
1.4
—
—
—
0
0
7
53
1.32
0.31
1.4
1.7
—
—
—
0
0
32
278
1.16
0.30
1.3
1.4
—
—
—
0
0
7
56
1.25
0.29
1.0
1.1
—
—
—
0
0
18
148
1.22
0.29
1.1
1.1
—
—
—
0
0
8
106
0.75
0.29
1.9
1.5
—
—
—
0
0
11
85
1.30
0.28
1.4
1.2
—
—
—
0
0
222
2132
1.05
0.26
2.9
2.7
0.7
0.7
ug/l
0.10
133
1302
17
141
1.21
0.26
1.4
1.5
—
—
—
0
0
26
298
0.87
0.25
1.5
1.7
—
—
—
0
0
12
96
1.25
0.24
1.9
1.4
—
—
—
0
0
11
87
1.27
0.24
1.6
1.6
—
—
—
0
0
336
3453
0.96
0.23
2.8
2.8
—
—
—
0
0
105
991
1.07
0.23
1.4
1.4
—
—
—
0
0
5
39
1.28
0.23
1.8
2.3
—
—
—
0
0
5
39
1.28
0.23
4.0
3.6
—
—
—
0
0
7
93
0.75
0.22
1.0
1.2
—
—
—
0
0
18
153
1.18
0.22
2.7
3.2
3.8
4.2
e9/l
0.38
18
153
104
983
1.06
0.22
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
7.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
2.1
—
0
12
8
103
0.77
0.21
1.7
1.4
—
—
—
0
0
8
103
0.77
0.21
1.8
1.4
—
—
—
0
0
878
8711
1.05
0.21
4.9
4.4
4.6
4.7
mmol/l
1.02
813
8147
0
14
0.00
0.20
0.0
9.1
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
0
14
0.00
0.20
0.0
6.3
—
—
—
0
0
28
250
1.12
0.20
1.2
1.2
—
—
—
0
0
6
50
1.20
0.19
9.3
6.6
—
—
—
0
0
19
165
1.15
0.19
1.0
1.2
373.6
259.1
u/ml
0.48
14
101
845
8384
1.04
0.18
4.4
3.9
1.4
1.3
mmol/l
0.76
770
7765
41
378
1.09
0.17
5.0
3.2
—
—
—
0
0
8
73
1.10
0.15
1.5
1.2
—
—
—
0
0
18
159
1.13
0.15
3.1
3.5
56.7
55.3
%
0.23
18
159
54
508
1.07
0.14
3.5
2.5
—
—
—
0
0
8
98
0.81
0.13
2.3
2.4
—
—
—
0
0
61
642
0.95
0.13
1.2
1.4
—
—
—
0
0
12
104
1.16
0.12
2.3
1.4
0.2
0.3
nmol/l
0.21
12
82
67
640
1.05
0.12
1.4
1.7
—
—
—
0
0
19
209
0.91
0.11
6.8
4.2
—
—
—
0
0
56
534
1.05
0.11
1.2
1.3
—
—
—
0
0
23
212
1.09
0.10
2.4
2.3
14.3
124.8
ug/min
1.83
15
124
871
8673
1.02
0.09
4.9
4.3
1.4
1.4
mmol/l
2.27
799
8071
14
126
1.11
0.09
1.3
1.3
—
—
—
0
0
233
2363
0.98
0.07
1.4
1.4
—
—
—
0
0
15
137
1.10
0.07
1.1
1.0
—
—
—
0
0
29
274
1.06
0.07
1.3
1.4
—
—
—
0
0
8
75
1.07
0.07
1.0
1.2
—
—
—
0
0
94
963
0.97
0.07
1.5
1.6
—
—
—
0
0
745
7482
0.99
0.06
20.7
16.4
333.6
333.3
g/l
0.28
740
7426
28
266
1.05
0.06
1.2
1.3
—
—
—
0
0
23
217
1.06
0.06
1.1
1.1
—
—
—
0
0
10
91
1.10
0.04
2.3
2.3
—
—
—
0
0
10
91
1.10
0.04
1.0
1.3
—
—
nmol/l
—
0
0
27
260
1.04
0.03
8.2
7.8
1.5
1.2
mmol/l
0.40
22
231
15
142
1.06
0.02
1.2
1.1
—
11.6
—
0
8
46
451
1.02
0.02
1.4
1.7
—
—
—
0
0
13
124
1.05
0.00
1.0
1.1
1.5
1.5
g/l
0.11
13
113
14
136
1.03
0.00
1.4
1.2
13.1
3.4
u/ml
—
7
56
22
216
1.02
0.00
1.2
1.2
—
—
—
0
0
10
99
1.01
0.00
1.3
1.3
—
—
—
0
0
11
105
1.05
0.00
1.3
1.3
0.9
0.6
nmol/l
0.83
11
97
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.8
1.4
6.6
6.7
u/l
—
5
44
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
7.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
41.9
—
0
7
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
2.5
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
7.3
—
16.8
—
0
6
0
5
0.00
0.00
0.0
2.4
—
203.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
0.00
1.4
2.1
11.8
11.6
%
—
7
73
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
0.1
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
34.3
—
0
5
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_BONEDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_BONEDISNAS 1.434 [1.18, 1.74] < 0.001
Birth year 0.994 [0.99, 1.0] 0.203

During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 1536 females with M13_BONEDISNAS died.

Males

Parameter HR [95% CI] p-value
M13_BONEDISNAS 1.396 [1.14, 1.7] 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 1231 males with M13_BONEDISNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_BONEDISNAS.

N-year risk Females Males
1 0.111% 0.265%
5 0.864% 1.517%
10 2.15% 3.733%
15 3.897% 7.014%
20 7.024% 12.433%

Relationships between endpoints

↥

Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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