endocrine system disease: A disease involving the endocrine system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
746 |
4. Check minimum number of eventsNone |
746 |
5. Include endpointsNone |
746 |
6. Filter based on genotype QC (FinnGen only) |
746 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Endocrine disorders, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4629 | 2915 | 1690 |
| Only index persons | 4059 | 2629 | 1430 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.05 |
| Only index persons | 0.08 | 0.10 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 45.31 | 43.58 | 47.96 |
| Only index persons | 42.47 | 41.28 | 44.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 746 | 499 | 247 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.11 |
| Median age at first event (years) | 43.89 | 40.67 | 50.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 703
- Matched controls
- 7031
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
323.0
558
*
H02AB09
ATC
hydrocortisone; systemic
32.3
66.5
88
31
ZXE00
NOMESCO Finland
One hour or less
4.0
65.9
428
1961
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
138.1
59.9
63
5
25898
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Alii definiti
+∞
58.1
55
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
111.2
56.8
61
6
H03AA01
ATC
levothyroxine sodium; systemic
3.9
53.1
287
1062
25899
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Other and unspecified diseases of endocrine system
+∞
48.5
46
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.2
46.0
355
1684
XX3DW
NOMESCO Finland
Time consuming IT work
5.4
44.9
149
334
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
42.1
40
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
40.0
38
*
E34.8
ICD-10 Finland
Other specified endocrine disorders
+∞
40.0
38
*
SPAT1262
SPAT
Handing over of treatment supplies
3.8
39.1
198
663
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.7
35.0
107
214
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
4.3
34.8
143
393
SPAT1312
SPAT
General health counselling
2.8
34.3
311
1551
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.7
34.2
362
1978
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
6.6
33.0
89
151
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.2
32.8
204
786
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
32.5
31
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
7.5
32.5
80
119
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
31.2
353
1967
SPAT1249
SPAT
Treatment-related counselling outside office
2.5
28.1
345
1973
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
+∞
26.2
25
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
270.1
25.9
26
*
H01CB02
ATC
octreotide; parenteral
140.2
25.8
27
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.8
25.5
75
142
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
25.3
243
1201
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
25.2
24
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
258.8
24.8
25
*
WX723
NOMESCO Finland
CPAP therapy
7.0
24.2
61
94
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
24.1
250
1281
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
24.0
137
484
SPAT1263
SPAT
Sampling
2.3
23.9
355
2170
UJF32
NOMESCO Finland
Coloscopy
2.5
23.1
218
1055
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
23.0
22
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
23.0
22
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
22.7
254
1346
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
22.4
232
1176
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
4.4
22.2
84
209
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.2
21.9
46
53
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.4
21.1
79
195
J01MA12
ATC
levofloxacin; systemic
2.7
20.3
155
656
SPAT1310
SPAT
Counselling related to known health issue
2.2
19.9
264
1496
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
19.9
19
*
SPAT1377
SPAT
Polysomnography
5.8
19.2
55
101
104
Kela drug reimbursment
Thyroid insufficiency
3.8
18.4
83
242
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
18.2
18.4
28
16
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
18.0
82
241
-1
SPAT
NA
5.6
17.9
53
101
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
17.9
93
304
ZXD00
NOMESCO Finland
Emergency procedure
5.7
17.9
52
97
A02BC01
ATC
omeprazole; systemic
2.2
17.6
220
1199
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.6
17.6
62
144
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.3
17.5
94
315
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
17.2
125
512
A11CC03
ATC
alfacalcidol; systemic
8.4
17.0
37
46
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
16.8
99
353
G02CB01
ATC
bromocriptine; systemic
9.6
16.8
34
37
SPAT1153
SPAT
Removal of sutures
2.1
16.7
245
1424
H01AC01
ATC
somatropin; parenteral
+∞
16.7
16
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.6
16.7
49
93
-44
ICPC
Preventive immunization/medic
3.5
16.5
81
253
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
16.4
199
1061
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
6.1
16.1
44
76
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
21.6
16.1
23
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
16.0
277
1720
N06AA09
ATC
amitriptyline; systemic
3.1
15.8
94
337
G47.3
ICD-10 Finland
Sleep apnoea
2.3
15.8
167
835
SPAT1301
SPAT
No procedures
2.1
15.7
246
1461
E26.0
ICD-10 Finland
Primary hyperaldosteronism
+∞
15.7
15
*
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
87.1
15.6
17
*
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
87.1
15.6
17
*
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
163.5
15.5
16
*
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
3.1
15.4
91
324
XFE00
NOMESCO Finland
Epicardial ultrasonography
7.6
15.1
35
48
WX780
NOMESCO Finland
Remote monitoring CPAP
4.7
15.1
52
118
WX110
NOMESCO Finland
Local anesthesy
2.0
14.9
499
3903
H01CB03
ATC
lanreotide; parenteral
58.0
14.8
17
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
14.8
259
1600
A02BC02
ATC
pantoprazole; systemic
1.9
14.8
462
3518
WX402
NOMESCO Finland
General anaesthesia
2.4
14.8
141
668
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
11.7
14.4
26
23
A12AA04
ATC
calcium carbonate; oral
11.2
14.1
26
24
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
9.1
14.1
29
33
S02.51
ICD-10 Finland
Fracture of tooth, open
2.8
13.8
91
349
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
13.6
13
*
BCA30
NOMESCO Finland
Unilateral adrenalectomy
+∞
13.6
13
*
XF404
NOMESCO Finland
Ambulatory ECG
3.0
13.5
81
292
UDC00
NOMESCO Finland
Ear microscopy
3.2
13.4
73
247
Z01.9
ICD-10 Finland
Special examination, unspecified
3.7
13.4
60
175
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
40.9
13.2
16
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
40.9
13.2
16
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
13.2
334
2328
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
6.0
13.2
36
63
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
5.1
13.1
41
84
205
Kela drug reimbursment
Chronic hypertension
2.1
13.1
179
996
WX400
NOMESCO Finland
Inhalation anesthesy
3.9
12.7
53
145
C03CA01
ATC
furosemide; systemic
2.0
12.7
178
998
121
Kela drug reimbursment
Severe hypofunction of sexual glands
6.8
12.6
31
47
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
12.6
159
851
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
12.5
12
*
8240/3-C17.9
ICD-O-3
Neuroendocrine tumor, NOS, of small intestine, NOS
+∞
12.5
12
*
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.5
12
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
12.5
12
*
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
12.5
12
*
E83.50
ICD-10 Finland
Hypercalcemia
14.7
12.3
20
14
SPAT1324
SPAT
Screening procedure
0.3
12.2
27
837
H02AB06
ATC
prednisolone; systemic
1.8
12.1
327
2304
N02AX02
ATC
tramadol; systemic, rectal
1.8
12.1
291
1976
HAHOM
NOMESCO Finland
NA
7.4
12.1
28
39
-50
ICPC
Medication/prescr/renewal
4.0
12.1
48
126
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
11.9
176
1003
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
11.9
137
702
E0000UV
ATC
NA
1.8
11.9
293
2004
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
11.8
76
286
SPAT1211
SPAT
Application of soft bandage
2.8
11.8
79
304
J01DB01
ATC
cefalexin; oral
2.0
11.7
576
4902
JN7AN
NOMESCO Finland
Somatostatin receptor isotope imaging
+∞
11.5
11
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
121.9
11.5
12
*
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
121.9
11.5
12
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
11.4
39
89
T90
ICPC
Diabetes non-insulin dependent
2.1
11.4
151
823
N06AX16
ATC
venlafaxine; oral
2.3
11.4
119
583
Z2221
NOMESCO Finland
Medical doctor
0.4
11.4
61
1294
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
9.1
11.3
23
26
UKC02
NOMESCO Finland
Cystoscopy
2.4
11.3
103
473
N04BC06
ATC
cabergoline; oral (dopamine agonists)
35.7
11.3
14
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.4
11.3
103
475
JN4AD
NOMESCO Finland
Body CT examination
3.0
11.1
65
231
R50.9
ICD-10 Finland
Fever, unspecified
2.3
11.1
107
505
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
11.0
41
102
Z56.5
ICD-10 Finland
Uncongenial work
44.0
10.9
13
*
N05BA04
ATC
oxazepam; oral
1.9
10.9
183
1092
Z31.5
ICD-10 Finland
Genetic counselling
3.4
10.8
52
161
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
28.5
10.8
14
5
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
7.7
10.7
24
32
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
10.7
122
623
N02AA05
ATC
oxycodone; systemic
2.4
10.6
96
439
AA1AD
NOMESCO Finland
CT of head and brain
2.0
10.6
159
907
SPAT1260
SPAT
Consultation of another employee
2.1
10.4
137
741
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
10.4
72
284
T99
ICPC
Endocr/metab/nutrit disease other
8.4
10.4
22
27
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
10.3
121
624
C07AB02
ATC
metoprolol; systemic
2.1
10.3
134
723
SAD02
NOMESCO Finland
Assessment of need for oral health care, extensive
3.8
10.2
43
120
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
10.2
144
802
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
10.2
105
512
N02BE01
ATC
paracetamol; systemic, rectal
2.0
10.2
596
5205
N05AH04
ATC
quetiapine; oral
2.1
10.1
127
673
SPAT1281
SPAT
Other administrative function
2.7
10.1
70
276
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.9
10.1
189
1164
C03DA01
ATC
spironolactone; oral
2.6
10.1
74
303
E66.01
ICD-10 Finland
Obesity due to excess calories
2.6
10.1
76
314
YHMAS
NOMESCO Finland
NA
9.3
10.1
20
22
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
10.2
10.1
19
19
H02AA02
ATC
fludrocortisone; oral
14.8
10.0
16
11
R68.8
ICD-10 Finland
Other specified general symptoms and signs
12.4
9.9
17
14
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
9.8
81
353
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
9.8
78
333
R01AD12
ATC
fluticasone furoate; nasal
1.8
9.7
225
1483
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
13.6
9.7
16
12
C07AB07
ATC
bisoprolol; oral
1.7
9.7
288
2046
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
55.8
9.7
11
*
N06AX21
ATC
duloxetine; oral
2.3
9.6
90
418
K02
ICD-10 Finland
Dental caries
2.8
9.6
63
239
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
5.5
9.4
27
51
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
101.4
9.4
10
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
101.4
9.4
10
*
J01FF01
ATC
clindamycin; systemic
1.8
9.4
197
1258
H05BX01
ATC
cinacalcet; oral
+∞
9.4
9
*
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
9.4
9
*
WX610
NOMESCO Finland
Patient controlled analgesia
12.6
9.4
16
13
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
9.4
145
832
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
8.8
9.3
19
22
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
3.7
9.3
39
109
HMAK
NOMESCO Finland
NA
2.2
9.2
97
477
H03BB01
ATC
carbimazole; oral
3.4
9.2
43
131
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
9.1
283
2027
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
9.1
349
2646
SPAT1254
SPAT
Administration of medicine
2.2
9.1
100
501
-54
ICPC
Repair/fix-suture/cast/prosth device
5.0
9.1
28
58
OAB72
NOMESCO Finland
Weight control and weight loss guidance
10.2
9.1
17
17
Y0099
ICD-8 Finland
Investigation of endocrine system and metabolism
15.8
9.1
14
9
SPAT1097
SPAT
Recording of ECG
2.1
9.1
102
517
T82
ICPC
Obesity
3.5
9.1
41
122
SAA04
NOMESCO Finland
Special inverstigation of mouth
3.0
9.0
52
184
A02BA02
ATC
ranitidine; systemic
1.9
9.0
139
799
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
9.0
95
469
A02BC05
ATC
esomeprazole; systemic
1.7
8.9
276
1974
ED1AA
NOMESCO Finland
Mandipular X-ray examination
12.7
8.9
15
12
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
8.9
148
875
130
Kela drug reimbursment
Malignant tumour
2.7
8.8
59
229
M79.6
ICD-10 Finland
Pain in limb
1.7
8.8
243
1680
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.4
8.7
72
315
E03
ICD-10 Finland
Other hypothyroidism
2.8
8.7
55
206
ZX070
NOMESCO Finland
Intensity modified radiotherapy
6.7
8.7
21
32
321
Kela drug reimbursment
Paricalcitol and cinacalcet
50.6
8.7
10
*
SPAT1094
SPAT
Continuous Positive Airway Pressure
7.8
8.7
19
25
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
8.7
221
1491
R51
ICD-10 Finland
Headache
3.2
8.7
45
149
B03BA03
ATC
hydroxocobalamin; parenteral
3.1
8.6
47
161
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.2
8.6
88
427
N06AB04
ATC
citalopram; systemic
1.8
8.6
160
979
ZXD05
NOMESCO Finland
Urgent procedure
1.7
8.6
223
1512
R55
ICD-10 Finland
Syncope and collapse
2.3
8.6
76
345
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.5
168
1049
WZC30
NOMESCO Finland
Teaching
2.1
8.4
97
494
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.7
8.4
35
98
A04AA02
ATC
granisetron; systemic, transdermal
2.9
8.4
49
176
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
2.6
8.4
60
243
E27.5
ICD-10 Finland
Adrenomedullary hyperfunction
+∞
8.3
8
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
8.3
8
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
+∞
8.3
8
*
318
Kela drug reimbursment
Teriparatide
+∞
8.3
8
*
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
+∞
8.3
8
*
E21.2
ICD-10 Finland
Other hyperparathyroidism
+∞
8.3
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
8.3
71
313
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
10.9
8.3
15
14
R4180
NOMESCO Finland
Podiatric therapy
9.6
8.3
16
17
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
7.2
8.3
19
27
WZA10
NOMESCO Finland
Long statement of health and health related matters
7.2
8.3
19
27
N06AX11
ATC
mirtazapine; oral
1.7
8.3
212
1431
N03AX16
ATC
pregabalin; oral
1.8
8.2
157
965
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.4
8.2
39
121
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.7
8.2
55
213
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
8.2
124
706
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.8
8.2
152
929
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
8.2
129
745
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
6.9
8.1
19
28
D82
ICPC
Teeth/gum disease
1.6
8.0
248
1759
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.5
8.0
27
62
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
8.0
160
1001
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
8.0
98
513
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
3.8
7.9
32
87
ZXA00
NOMESCO Finland
Right side
0.5
7.9
60
1144
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.1
7.9
90
457
C08CA01
ATC
amlodipine; oral
1.7
7.9
205
1384
JN4CD
NOMESCO Finland
Very extensive body CT
3.6
7.8
33
94
C10AC01
ATC
colestyramine; oral
4.0
7.7
29
74
SCA03
NOMESCO Finland
Preventive oral health care, extensive
3.1
7.6
40
134
R53
ICD-10 Finland
Malaise and fatigue
1.8
7.6
138
835
SPAT1238
SPAT
Brief therapy
4.4
7.6
26
61
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
7.5
173
1125
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
80.9
7.4
8
*
A11CC02
ATC
dihydrotachysterol; oral
80.9
7.4
8
*
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
80.9
7.4
8
*
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
5.7
7.4
20
36
L68.0
ICD-10 Finland
Hirsutism
13.5
7.4
12
9
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.4
7.4
63
281
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
7.4
94
501
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.1
7.3
27
68
R06AE07
ATC
cetirizine; oral
1.6
7.3
302
2286
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.3
79
392
103
Kela drug reimbursment
Diabetes, insulin-treated
1.7
7.3
158
1007
E21.5
ICD-10 Finland
Disorder of parathyroid gland, unspecified
+∞
7.3
7
*
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
7.3
7
*
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
7.3
7
*
BB1AN
NOMESCO Finland
Parathyroid gland isotope imaging, 1 isotope
+∞
7.3
7
*
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
7.3
7
*
N03AE01
ATC
clonazepam; systemic
2.8
7.3
46
172
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.0
7.3
39
133
SPAT1240
SPAT
Therapeutic discussion
2.1
7.3
83
422
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.5
7.3
20
37
E29.1
ICD-10 Finland
Testicular hypofunction
15.9
7.2
11
7
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
7.4
7.2
16
22
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
7.2
42
151
WX204
NOMESCO Finland
Axillary plexus blockaced
3.6
7.2
31
90
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
30.3
7.2
9
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.2
7.2
35
112
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
7.1
59
259
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.7
7.1
29
80
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
7.1
7.0
16
23
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.5
7.0
31
92
A10BK03
ATC
empagliflozin; oral
2.6
7.0
50
204
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
6.4
7.0
17
27
BAA60
NOMESCO Finland
Total thyroidectomy
4.5
6.9
23
53
N06AX12
ATC
bupropion; oral
2.5
6.9
52
219
R83
ICPC
Respiratory infection other
0.5
6.8
66
1171
S02.5
ICD-10 Finland
Fracture of tooth
3.8
6.8
27
73
E87.6
ICD-10 Finland
Hypokalaemia
3.9
6.8
26
68
ZXC50
NOMESCO Finland
Cryotherapy
4.6
6.8
22
49
SPAT1325
SPAT
Vaccination
1.6
6.8
213
1504
E83.51
ICD-10 Finland
Hypocalcemia
16.9
6.8
10
6
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.4
6.7
56
247
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
5.0
6.7
20
41
ZXH04
NOMESCO Finland
Procedure performed in other inpatient unit
22.8
6.7
9
*
S18
ICPC
Laceration/cut
1.5
6.7
261
1942
XKD00
NOMESCO Finland
Uroflowmetry
2.0
6.6
79
410
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.3
6.6
58
262
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.0
6.6
36
125
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
4.4
6.6
22
51
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.6
113
672
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.2
6.6
23
56
GD2SN
NOMESCO Finland
Lung ventilation SPECT
10.1
6.6
12
12
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
6.9
6.5
15
22
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.1
6.5
34
115
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
70.5
6.4
7
*
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.7
6.4
41
155
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
6.4
113
674
N06AX18
ATC
reboxetine; oral
6.6
6.4
15
23
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
6.6
6.4
15
23
SPAT1341
SPAT
Referral to physician or dentist
8.3
6.4
13
16
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.3
6.3
54
242
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
6.0
6.3
16
27
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
6.3
72
365
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
4.6
6.3
20
44
U04
ICPC
Incontinence urine
3.0
6.3
33
112
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
18.2
6.3
9
5
NA3CM
NOMESCO Finland
Lumbar spine extensive MRI examination with 3 Tesla magnet
18.2
6.3
9
5
B81
ICPC
Anaemia vit B12/folate deficiency
3.2
6.3
31
101
A09AA02
ATC
multienzymes (lipase, protease etc.)
4.9
6.3
19
40
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.9
6.3
19
40
C74.0
ICD-10 Finland
Malignant neoplasm: Cortex of adrenal gland
+∞
6.3
6
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
+∞
6.3
6
*
E26.9
ICD-10 Finland
Hyperaldosteronism, unspecified
+∞
6.3
6
*
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
+∞
6.3
6
*
2520A
ICD-9 Finland
Disorders of parathyroid gland, Hyperparathyroidism
+∞
6.3
6
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
H05AA02
ATC
teriparatide; parenteral
+∞
6.3
6
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
7.1
6.2
14
20
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
26.9
6.2
8
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
26.9
6.2
8
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
6.2
118
720
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
2.7
6.2
41
160
B01AB10
ATC
tinzaparin; parenteral
2.3
6.2
55
248
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
6.2
93
527
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
6.2
51
225
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
6.2
89
496
N03AX12
ATC
gabapentin; oral
1.8
6.2
101
586
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.1
92
519
N03AX09
ATC
lamotrigine; oral
2.7
6.1
40
155
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
12.7
6.1
10
8
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.0
6.0
22
56
Mortality – FinRegistry
↥Association
Association between endpoint E4_ENDODISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDODISNAS | 1.723 [1.5, 1.98] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.433 |
During the follow-up period (1.1.1998 — 31.12.2019), 435 out of 2137 females with E4_ENDODISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDODISNAS | 2.082 [1.77, 2.45] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 361 out of 1294 males with E4_ENDODISNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ENDODISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.487% |
| 5 | 0.917% | 2.933% |
| 10 | 2.625% | 6.936% |
| 15 | 5.304% | 12.736% |
| 20 | 8.779% | 21.356% |
Relationships between endpoints
↥Index endpoint: E4_ENDODISNAS – Endocrine disorders, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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