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Disorder of the sleep-wake schedule

EFO Endpoint Browser PheWeb

F5_SLEEPWAKE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F51.2, G47.2
  • Hospital discharge: ICD-9 — 3074F
  • Cause of death: ICD-10 — F51.2, G47.2
  • Cause of death: ICD-9 — 3074F

2 out of 7 registries used, show all original rules.

712

4. Check minimum number of events

None

712

5. Include endpoints

None

712

6. Filter based on genotype QC (FinnGen only)

677

Control definitions (FinnGen only)

Control exclude
F5_SLEEP

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6901 3035 3847
Only index persons 5380 2449 2931
Unadjusted period prevalence (%)
Whole population 0.10 0.09 0.11
Only index persons 0.10 0.09 0.11
Median age at first event (years)
Whole population 17.72 18.07 17.36
Only index persons 23.48 23.54 23.43

-FinnGen-

Key figures

All Female Male
Number of individuals 677 368 309
Unadjusted period prevalence (%) 0.14 0.13 0.14
Median age at first event (years) 43.34 39.82 47.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
711
Matched controls
7110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F51.2
ICD-10 Finland
Nonorganic disorder of the sleep-wake schedule
988.1
307.7
327
6
G47.2
ICD-10 Finland
Disorders of the sleep-wake schedule
6663.7
307.7
364
*
F51.0
ICD-10 Finland
Nonorganic insomnia
+∞
277.9
248
*
N05AH04
ATC
quetiapine; oral
6.8
133.9
298
685
G47.3
ICD-10 Finland
Sleep apnoea
6.3
124.9
309
778
N06AX11
ATC
mirtazapine; oral
5.6
115.9
367
1135
G47.9
ICD-10 Finland
Sleep disorder, unspecified
15.7
94.5
85
61
IAB13
NOMESCO Finland
Psychiatric sleep disorder consultation
936.2
86.5
83
*
N06AX12
ATC
bupropion; oral
6.4
77.9
149
284
F51.9
ICD-10 Finland
Nonorganic sleep disorder, unspecified
17.8
74.5
62
38
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.9
70.1
191
496
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
14.9
69.8
64
47
N06AX16
ATC
venlafaxine; oral
4.7
67.0
190
508
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.6
65.3
193
532
N06AX22
ATC
agomelatine; oral
15.6
61.9
55
38
N05CF01
ATC
zopiclone; oral
3.8
61.5
267
967
N06AX05
ATC
trazodone; oral
13.9
61.2
58
45
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.9
59.8
119
233
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
8.5
59.4
81
106
F61.0
ICD-10 Finland
Mixed personality disorders
15.0
58.5
53
38
N05CF02
ATC
zolpidem; oral
4.2
53.3
172
501
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
6.9
53.0
87
140
G47.0
ICD-10 Finland
Disorders of initiating and maintaining sleep [insomnias]
+∞
52.8
50
*
P06
ICPC
Sleep disturbance
4.6
52.5
147
384
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
6.8
52.4
88
145
IEY18
NOMESCO Finland
Psychiatric sleep coaching, individual
546.1
52.2
51
*
N05BA04
ATC
oxazepam; oral
3.5
51.8
241
899
N06AB04
ATC
citalopram; systemic
3.8
50.8
193
629
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.7
48.1
98
195
N06AB10
ATC
escitalopram; oral
3.4
47.5
237
917
ZY010
NOMESCO Finland
Hospital outpatient
5.0
46.9
111
252
N06AX21
ATC
duloxetine; oral
4.4
46.4
133
352
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.3
45.8
139
384
N06AB06
ATC
sertraline; oral
4.0
44.9
151
449
N03AX16
ATC
[U] pregabalin
3.4
43.1
197
717
3074F
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Specific disorders of sleep of nonorganic origin[UNIVALVERYTMIN HÄIRIÖ]
+∞
42.1
40
*
N06AB03
ATC
fluoxetine; oral
3.9
41.4
141
422
N05AH03
ATC
olanzapine; systemic
4.8
41.3
102
239
F34.1
ICD-10 Finland
Dysthymia
7.0
41.2
66
103
R5140
NOMESCO Finland
Monitoring the use of the aid
4.2
39.1
118
323
N03AX09
ATC
lamotrigine; oral
5.2
38.9
87
187
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.6
38.9
154
509
R53
ICD-10 Finland
Malaise and fatigue
3.0
38.0
230
979
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
6.5
37.8
65
109
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
5.2
36.9
82
175
N06BA04
ATC
methylphenidate; oral
4.6
36.4
93
223
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
5.3
35.8
76
156
Z2445
NOMESCO Finland
Psychologist
4.7
35.6
89
210
P03
ICPC
Feeling depressed
3.5
35.4
146
493
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.1
34.7
107
296
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
6.8
34.2
55
86
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.3
33.3
95
248
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
5.2
33.3
73
154
N06AX03
ATC
mianserin; oral
6.9
31.9
51
79
IBA03
NOMESCO Finland
Psychotherapy evaluation
9.3
30.9
38
43
N05AX12
ATC
aripiprazole; systemic
4.8
30.9
75
172
N03AE01
ATC
clonazepam; systemic
5.2
30.8
67
140
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.0
30.6
70
153
N05BA01
ATC
diazepam; systemic, rectal
3.5
30.4
118
381
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
7.8
30.4
43
58
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.7
30.0
74
172
P76
ICPC
Depressive disorder
3.9
30.0
97
277
F41.1
ICD-10 Finland
Generalized anxiety disorder
4.1
30.0
89
239
N06AA09
ATC
amitriptyline; systemic
4.4
29.8
80
199
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
4.7
29.0
71
164
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.2
28.2
130
466
IGY02
NOMESCO Finland
Psychiatric monitoring contact
4.8
27.9
66
148
XG466
NOMESCO Finland
Sleep oxymetry
7.1
27.9
43
64
N06AX26
ATC
vortioxetine; oral
3.8
27.9
94
276
R06.5
ICD-10 Finland
Mouth breathing
3.5
27.5
106
340
N03AG01
ATC
valproic acid; systemic, rectal
4.1
27.1
79
209
N06AB05
ATC
paroxetine; oral
4.5
27.0
69
165
M79.7
ICD-10 Finland
Fibromyalgia
6.6
26.8
44
70
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
10.8
25.5
28
27
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
5.1
25.0
54
112
N05AA02
ATC
levomepromazine; systemic
5.5
24.9
50
97
P29
ICPC
Psychological sympt/compl other
3.2
24.6
106
364
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
21.0
24.5
36
18
N05CD07
ATC
temazepam; oral
3.9
24.3
77
216
Z2446
NOMESCO Finland
Social worker
3.4
24.0
97
320
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.7
23.6
80
235
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.8
23.4
76
217
N03AX12
ATC
[U] gabapentin; oral
2.9
23.3
128
504
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
5.1
23.3
51
107
N04BC05
ATC
pramipexole; oral
4.2
22.9
65
168
N06BA12
ATC
lisdexamfetamine; oral
7.0
22.7
35
52
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
6.4
22.6
38
62
F51
ICD-10 Finland
Nonorganic sleep disorders
5.3
22.4
46
91
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
8.6
22.4
29
35
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.9
22.1
70
196
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.8
22.1
52
116
F41.09
ICD-10 Finland
UNS Panic Syndrome
4.9
22.0
50
108
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
6.1
22.0
39
67
F33
ICD-10 Finland
Recurrent depressive disorder
6.2
21.9
38
64
ZYC01
NOMESCO Finland
Remote contact by phone
3.7
21.7
73
213
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
6.0
21.7
39
68
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
6.5
21.6
36
58
IGY99
NOMESCO Finland
Other psychiatric treatment contact
4.7
21.6
51
114
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.4
21.5
82
260
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.2
21.4
45
91
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
21.3
104
383
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
21.0
194
978
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.4
20.9
54
130
WX723
NOMESCO Finland
CPAP therapy
4.9
20.8
47
101
N05AX08
ATC
risperidone; systemic
3.4
20.8
80
255
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.5
20.7
77
240
A04
ICPC
Weakness/tiredness general
2.6
20.7
138
598
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.6
20.7
72
215
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
5.4
20.6
41
79
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
6.4
20.4
34
55
N05AF03
ATC
chlorprothixene; systemic
6.1
20.3
36
62
F60.9
ICD-10 Finland
Personality disorder, unspecified
8.2
20.1
27
34
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
19.7
291
1765
R40.0
ICD-10 Finland
Somnolence
41.4
19.6
24
6
A06AC01
ATC
ispaghula (psylla seeds); oral
2.4
19.4
172
849
WX722
NOMESCO Finland
PEEP
4.3
19.3
52
129
C07AA05
ATC
propranolol; systemic
2.3
19.2
172
852
P01
ICPC
Feeling anxious/nervous/tense
2.4
18.6
155
743
R03AC02
ATC
salbutamol; inhalant
2.0
18.4
421
2966
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
6.3
18.3
31
51
F41.8
ICD-10 Finland
Other specified anxiety disorders
4.3
18.2
48
117
A02BC02
ATC
pantoprazole; systemic
2.0
18.2
426
3020
R51.80
ICD-10 Finland
Headache
2.4
17.8
149
715
Z3231
NOMESCO Finland
Registered nurse
2.1
17.5
217
1222
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.8
17.2
54
150
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.4
17.1
64
200
G47.8
ICD-10 Finland
Other sleep disorders
6.1
17.1
30
51
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.5
16.9
61
186
P74
ICPC
Anxiety disorder/anxiety state
3.4
16.7
64
203
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
16.5
78
281
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
16.1
168
881
SPAT1240
SPAT
Therapeutic discussion
2.5
15.9
110
482
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
15.9
78
287
N02AX02
ATC
tramadol; systemic, rectal
2.0
15.6
262
1632
N05BE01
ATC
buspirone; oral
4.7
15.6
36
79
F39
ICD-10 Finland
Unspecified mood [affective] disorder
5.4
15.4
31
60
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.7
15.4
29
53
A02BC05
ATC
esomeprazole; systemic
1.9
15.1
252
1564
C03CA01
ATC
furosemide; systemic
2.3
15.0
138
686
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
14.9
83
326
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
5.0
14.9
32
66
P99
ICPC
Psychological disorders other
4.0
14.8
43
113
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.5
14.7
101
440
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
14.7
281
1819
R06.0
ICD-10 Finland
Dyspnoea
2.1
14.7
174
954
N06AG02
ATC
moclobemide; oral
4.5
14.7
36
83
F32.1
ICD-10 Finland
Moderate depressive episode
3.0
14.6
68
242
WX780
NOMESCO Finland
Remote monitoring CPAP
4.0
14.6
43
114
R52.2
ICD-10 Finland
Other chronic pain
4.3
14.6
38
92
N06AA12
ATC
doxepin; systemic
4.0
14.4
41
106
N06AA06
ATC
trimipramine; systemic
6.1
14.4
25
42
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
4.3
14.4
38
93
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
14.2
138
700
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
6.0
14.1
25
43
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.8
13.8
75
291
F32
ICD-10 Finland
Depressive episode
3.2
13.7
57
190
F31.8
ICD-10 Finland
Other bipolar affective disorders
4.6
13.7
33
75
N05AN01
ATC
lithium; oral
4.7
13.7
32
71
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.0
13.6
24
41
E66.8
ICD-10 Finland
Other obesity
3.3
13.6
52
165
D11
ICPC
Diarrhoea
2.3
13.4
115
554
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
5.5
13.3
26
49
M79.6
ICD-10 Finland
Pain in limb
1.8
13.3
274
1805
D01
ICPC
Abdominal pain/cramps general
2.3
13.3
112
535
K59.09
ICD-10 Finland
Constipation, unspecified
3.3
13.2
52
168
L28
ICPC
Limited function/disability (L)
2.4
13.2
96
430
L03
ICPC
Low back symptom/complaint
1.9
13.1
202
1212
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
4.1
12.9
36
92
R52.9
ICD-10 Finland
Pain, unspecified
2.6
12.8
81
339
A06AD11
ATC
lactulose; oral
2.5
12.8
84
358
N02BF02
ATC
pregabalin; oral
3.2
12.8
51
166
Z71.8
ICD-10 Finland
Other specified counselling
1.8
12.8
245
1574
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
12.6
54
183
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.3
12.6
48
152
G47.1
ICD-10 Finland
Disorders of excessive somnolence [hypersomnias]
+∞
12.5
12
*
R01AD09
ATC
mometasone; nasal
1.8
12.3
333
2364
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
12.2
104
499
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
5.0
12.0
26
54
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
12.0
169
980
L01
ICPC
Neck symptom/complaint
2.1
11.9
120
615
C07AB07
ATC
bisoprolol; oral
1.8
11.8
244
1595
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.8
11.8
36
98
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.5
11.7
77
328
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
11.6
232
1502
N05BA12
ATC
alprazolam; oral
2.6
11.5
68
275
H03AA01
ATC
levothyroxine sodium; systemic
2.0
11.5
144
800
M54.5
ICD-10 Finland
Low back pain
1.8
11.5
237
1548
R03BA05
ATC
fluticasone; inhalant
2.0
11.4
153
871
E66.00
ICD-10 Finland
Metabolic syndrome
3.2
11.4
46
151
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.6
11.4
68
277
ZY000
NOMESCO Finland
Hospital inpatient
5.0
11.3
24
49
Z2221
NOMESCO Finland
Medical doctor
1.9
11.2
193
1191
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
4.5
11.1
27
62
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
11.0
60
233
Z29
ICPC
Social problem NOS
4.3
10.9
28
67
A02BC03
ATC
lansoprazole; oral
1.9
10.9
160
937
K07.60
ICD-10 Finland
Snapping jaw
2.9
10.9
52
188
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
4.5
10.8
26
59
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.6
10.7
35
100
R03DC03
ATC
montelukast; oral
2.0
10.7
130
714
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
10.6
153
890
A28
ICPC
Limited function/disability NOS
2.3
10.6
82
377
A01
ICPC
Pain general/multiple sites
2.5
10.5
68
288
F51.1
ICD-10 Finland
Nonorganic hypersomnia
+∞
10.4
10
*
J02AC01
ATC
fluconazole; systemic
1.7
10.4
243
1635
SPAT1051
SPAT
Guidance regarding sleep disorders
5.0
10.3
22
45
N05BA06
ATC
lorazepam; systemic, sublingual
3.3
10.3
40
128
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.8
10.2
52
195
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
40.7
10.0
12
*
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
7.8
10.0
22
29
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.4
10.0
73
327
H02AB06
ATC
prednisolone; systemic
1.7
9.9
286
2031
F32.8
ICD-10 Finland
Other depressive episodes
5.2
9.9
20
39
G44.2
ICD-10 Finland
Tension-type headache
2.1
9.8
102
527
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
9.8
171
1054
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.0
9.8
44
154
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
9.7
79
370
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
9.7
94
473
N06BA07
ATC
modafinil; oral
13.6
9.7
16
12
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
9.7
86
418
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
9.7
119
654
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.0
9.7
44
155
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
9.6
62
262
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
9.6
62
262
A99
ICPC
Disease/condition unspecnature/site
2.5
9.6
64
275
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
9.6
269
1895
F51.8
ICD-10 Finland
Other nonorganic sleep disorders
15.3
9.5
15
10
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.7
9.5
52
202
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.7
9.5
30
84
Z3226
NOMESCO Finland
Physiotherapist
1.9
9.4
127
720
J31.0
ICD-10 Finland
Chronic rhinitis
2.3
9.4
73
335
A02BA02
ATC
ranitidine; systemic
2.1
9.4
98
507
M79.1
ICD-10 Finland
Myalgia
2.0
9.4
110
594
F51.3
ICD-10 Finland
Sleepwalking [somnambulism]
+∞
9.4
9
*
M25.5
ICD-10 Finland
Pain in joint
1.7
9.3
211
1400
R02
ICPC
Shortness of breath/dyspnoea
2.2
9.3
83
404
R96
ICPC
Asthma
2.4
9.3
66
292
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.8
9.2
28
76
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
13.9
9.2
15
11
DHB50
NOMESCO Finland
Turbinoplasty
3.7
9.2
29
81
R06AE07
ATC
cetirizine; oral
1.6
9.2
308
2263
D06
ICPC
Abdominal pain localized other
2.3
9.2
71
326
F93.89
ICD-10 Finland
Other childhood emotional disorders
4.5
9.1
22
50
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
4.9
9.1
20
42
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.6
9.0
30
87
TAB00
NOMESCO Finland
Lumbar puncture
2.9
8.9
43
157
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.8
8.8
157
971
G43.9
ICD-10 Finland
Migraine, unspecified
2.4
8.7
60
261
R11
ICD-10 Finland
Nausea and vomiting
2.3
8.6
70
328
L02
ICPC
Back symptom/complaint
2.1
8.6
81
403
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
7.1
8.6
20
29
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.5
135
805
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.8
8.5
26
71
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
8.5
146
892
F40.1
ICD-10 Finland
Social phobias
3.2
8.5
34
111
N02BE01
ATC
paracetamol; systemic, rectal
1.8
8.5
577
5019
P20
ICPC
Memory disturbance
2.5
8.5
54
227
N05AB03
ATC
perphenazine; systemic, rectal
3.6
8.4
28
81
SPAT1307
SPAT
Psychosocial counselling and guidance
2.2
8.4
74
358
Z01.2
ICD-10 Finland
Dental examination
1.6
8.4
346
2654
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
13.0
8.4
14
11
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.6
8.3
48
192
IBB03
NOMESCO Finland
Assessment of vocational rehabilitation needs in a mental health context
10.9
8.3
15
14
N03AX11
ATC
topiramate; oral
3.6
8.3
27
77
F41.00
ICD-10 Finland
Moderate panic disorder
4.2
8.3
22
54
N05AB01
ATC
dixyrazine; systemic
9.6
8.3
16
17
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
9.6
8.3
16
17
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
3.1
8.3
35
118
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
8.3
170
1093
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
8.2
88
459
A02BA03
ATC
famotidine; systemic
4.0
8.2
23
59
F84.5
ICD-10 Finland
Asperger syndrome
7.7
8.2
18
24
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
8.1
88
462
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
8.1
131
786
L17
ICPC
Foot/toe symptom/complaint
1.7
8.1
188
1251
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
8.0
264
1915
R03BA02
ATC
budesonide; inhalant
1.8
8.0
123
726
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.9
308
2321
A02BC01
ATC
omeprazole; systemic
1.7
7.9
157
999
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
4.7
7.9
18
39
IER01
NOMESCO Finland
Psychoeducation, group
7.9
7.9
17
22
F32.0
ICD-10 Finland
Mild depressive episode
3.6
7.9
26
75
T83
ICPC
Overweight
3.9
7.8
23
61
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
7.8
91
489
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
7.8
269
1969
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
7.1
7.8
18
26
S29
ICPC
Skin symptom/complaint other
1.8
7.8
128
771
L29
ICPC
Musculoskeletal sympt/complt other
2.4
7.8
56
249
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.8
162
1045
A07AA02
ATC
nystatin; oral
2.9
7.7
36
129
D07AC01
ATC
betamethasone; topical
1.6
7.7
217
1514
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.7
7.7
41
158
H02AB07
ATC
prednisone; oral
2.1
7.6
78
400
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
7.6
95
523
L12
ICPC
Hand/finger symptom/complaint
1.8
7.6
121
721
R4110
NOMESCO Finland
Physiotherapy
1.7
7.6
172
1133
SPAT1243
SPAT
Psychiatric/psychological examination
3.0
7.6
34
119
A07DA03
ATC
loperamide; oral
3.9
7.6
22
58
J46
ICD-10 Finland
Status asthmaticus
4.3
7.5
19
45
R05
ICPC
Cough
1.7
7.5
166
1088
M01AB05
ATC
diclofenac; systemic, rectal
1.5
7.5
393
3157
IEY01
NOMESCO Finland
Psychoeducation, individual
6.6
7.4
18
28
K30
ICD-10 Finland
Functional dyspepsia
2.1
7.4
71
356
R01AD58
ATC
fluticasone, combinations; nasal
1.7
7.4
179
1201
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
3.7
7.4
23
64
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.8
7.3
109
636
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
7.3
127
777
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
7.3
65
317
SPAT1153
SPAT
Removal of sutures
1.7
7.2
169
1122
M70.6
ICD-10 Finland
Trochanteric bursitis
2.1
7.2
66
325
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
3.3
7.2
27
85
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
7.1
130
806
R25.1
ICD-10 Finland
Tremor, unspecified
3.8
7.1
21
56
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
7.1
71
361
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
5.7
7.1
19
34
UJF32
NOMESCO Finland
Coloscopy
1.7
7.1
134
839
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.1
7.1
67
334
M03BX02
ATC
tizanidine; oral
1.5
7.1
376
3012
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.5
7.0
24
71
D02
ICPC
Abdominal pain epigastric
2.4
7.0
49
215
SAA02
NOMESCO Finland
Basic examination of mouth
1.6
7.0
512
4393
M02AA10
ATC
ketoprofen; topical
2.0
7.0
83
449
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.7
7.0
37
142
IGP01
NOMESCO Finland
Psychiatric family contact
3.8
7.0
21
57
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
6.9
128
796
N07BB01
ATC
disulfiram; oral
2.9
6.9
32
114
N05AE04
ATC
ziprasidone; systemic
7.6
6.9
15
20
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
6.9
107
632
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.3
6.9
26
82
SPAT1395
SPAT
Health check-up of persons outside student and working life
3.4
6.9
24
72
K59.0
ICD-10 Finland
Constipation
2.6
6.9
39
155
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
8.4
6.8
14
17
F41.3
ICD-10 Finland
Other mixed anxiety disorders
3.9
6.8
20
53
XF402
NOMESCO Finland
ECG with work load test
2.2
6.8
57
270
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
11.1
6.8
12
11
ZXY83
NOMESCO Finland
Social worker in multidisciplinary team
11.1
6.8
12
11
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.7
6.8
37
144
K02.1
ICD-10 Finland
Caries of dentine
1.5
6.8
435
3613
ZXC60
NOMESCO Finland
Application of heat
4.3
6.8
17
40
IHZ05, ,
SPAT
2.4
6.8
44
187
J01AA02
ATC
doxycycline; systemic
1.5
6.7
440
3666
F45.8
ICD-10 Finland
Other somatoform disorders
2.2
6.7
59
286
C09CA06
ATC
candesartan; oral
1.7
6.7
126
788
R42
ICD-10 Finland
Dizziness and giddiness
1.8
6.7
115
701
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.1
6.7
62
307
Z08
ICPC
Social welfare problem
6.5
6.7
16
25
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.9
6.7
31
111
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
6.6
160
1068
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.6
219
1576
J34.2
ICD-10 Finland
Deviated nasal septum
2.4
6.6
45
195
SPAT1238
SPAT
Brief therapy
3.6
6.6
21
59
J01FA06
ATC
roxithromycin; oral
1.6
6.6
222
1603
R21
ICPC
Throat symptom/complaint
1.6
6.6
198
1393
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
6.6
507
4365
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
6.6
181
1247
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.6
270
2037
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.1
6.6
27
90
SPAT1053
SPAT
Memory test
2.2
6.6
53
248
ZXY03
NOMESCO Finland
Occupational therapist
10.1
6.5
12
12
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.6
6.5
38
153
R06AX22
ATC
ebastine; oral
1.8
6.5
107
643
N06AB08
ATC
fluvoxamine; oral
3.6
6.5
21
60
XA800
NOMESCO Finland
Neuropsychological investigation
2.5
6.5
40
166
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.0
6.5
18
46
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.5
6.5
22
65
S18
ICPC
Laceration/cut
1.5
6.4
265
2000
F50.9
ICD-10 Finland
Eating disorder, unspecified
4.1
6.4
17
42
R03BA08
ATC
ciclesonide; inhalant
2.1
6.4
57
278
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
8.3
6.4
13
16
N06AX17
ATC
milnacipran; oral
8.3
6.4
13
16
F60.5
ICD-10 Finland
Anankastic personality disorder
6.0
6.3
16
27
A97
ICPC
No disease
1.7
6.3
134
865
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.3
73
392
J45
ICD-10 Finland
Asthma
2.0
6.3
65
335
WZC00, ,
SPAT
1.9
6.2
80
445
C08CA02
ATC
felodipine; oral
2.5
6.2
39
163
EB1MA
NOMESCO Finland
Cephalometry with X-ray
2.6
6.2
35
139
K60.1
ICD-10 Finland
Chronic anal fissure
3.6
6.2
20
57
T90
ICPC
Diabetes non-insulin dependent
1.7
6.1
113
701
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
7.8
6.1
13
17
ZXY60
NOMESCO Finland
2-person team, nurses
7.8
6.1
13
17
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
6.1
89
515
N05AD01
ATC
haloperidol; systemic
3.8
6.1
18
48
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
4.2
6.1
16
39
R60.0
ICD-10 Finland
Localized oedema
2.1
6.1
60
304
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.2
6.1
51
243
P80
ICPC
Personality disorder
10.1
6.0
11
11
R73.0
ICD-10 Finland
Abnormal glucose tolerance test
3.4
6.0
21
63
F41.01
ICD-10 Finland
Severe panic disorder
6.1
6.0
15
25
SPAT1197
SPAT
Extensive health check-up of expecting family
0.4
6.0
31
719

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
205
743
3.47
45.41
2.4
2.4
14.51
13.95
umol/l
0.50
195
691
347
1740
2.94
43.45
2.2
1.8
96.03
95.05
pmol/l
0.14
195
908
190
679
3.45
42.77
2.3
2.4
2.40
2.40
g/l
0.02
177
629
237
977
3.14
42.00
1.6
1.4
19.08
20.72
nmol/l
1.01
216
832
177
625
3.44
40.40
2.4
2.4
24.09
23.55
%
0.20
162
551
314
1538
2.87
40.39
2.6
3.2
2.36
2.36
mmol/l
0.18
291
1397
377
2140
2.62
34.77
6.4
7.7
1.23
1.22
mmol/l
1.65
350
1970
563
3904
3.12
34.75
7.5
7.0
79.83
81.70
u/l
0.41
540
3671
375
2128
2.61
34.53
2.7
2.3
72.25
73.41
nmol/l
0.34
351
1943
87
207
4.65
34.37
2.2
2.6
—
—
—
0
0
397
2339
2.58
33.44
6.8
7.8
1.22
1.22
mmol/l
2.34
342
2005
581
4251
3.01
29.54
4.9
3.7
14.48
14.59
pmol/l
0.46
541
3863
166
696
2.81
27.15
2.0
1.7
1048.69
1126.42
nmol/l
0.51
130
522
333
1952
2.33
26.43
4.8
5.4
36.81
36.51
g/l
0.44
309
1828
319
1849
2.32
25.85
3.6
3.4
26.97
31.36
u/l
1.94
303
1764
538
3925
2.52
24.93
4.7
3.8
9.66
9.93
mm/h
0.22
514
3621
407
2650
2.25
24.45
3.7
2.7
94.00
94.25
ug/l
0.01
380
2456
132
536
2.80
22.64
2.4
2.2
408.74
373.88
nmol/l
0.91
121
500
462
3249
2.20
21.85
9.2
8.9
4.09
3.96
e9/l
0.63
400
2819
403
2693
2.15
21.67
6.4
6.6
—
—
—
0
0
102
368
3.07
21.64
2.1
2.1
—
—
—
0
0
427
2935
2.14
21.11
6.3
6.6
0.19
0.19
e9/l
0.27
377
2596
174
847
2.40
20.34
1.8
1.6
43662392.74
30332833.54
pmol/l
0.11
142
722
629
5133
2.95
20.05
6.2
4.3
1.80
2.09
mu/l
0.65
591
4734
413
2840
2.08
19.93
6.1
6.2
0.04
0.04
e9/l
0.24
367
2461
424
2949
2.08
19.78
6.2
6.2
2.13
2.02
e9/l
0.91
384
2630
411
2834
2.07
19.53
6.2
6.2
0.58
0.56
e9/l
0.52
365
2456
90
323
3.05
19.19
3.2
2.8
—
—
—
0
0
383
2587
2.04
19.11
6.7
6.4
0.68
0.67
%
0.11
365
2428
395
2703
2.04
18.95
6.8
6.5
8.11
8.33
%
0.78
380
2546
403
2780
2.04
18.88
6.3
6.1
55.42
55.40
%
0.01
387
2630
383
2598
2.03
18.77
5.7
6.3
11.88
13.78
umol/l
1.16
353
2450
405
2807
2.03
18.63
6.7
6.3
30.43
30.03
%
0.34
388
2654
392
2689
2.02
18.52
6.5
6.3
2.73
2.89
%
0.74
376
2527
516
3923
2.15
18.21
4.1
3.0
44.38
40.48
u/l
0.59
496
3723
620
5095
2.69
18.11
4.8
3.7
5.88
5.78
mmol/l
0.88
574
4676
110
460
2.65
17.59
2.1
2.1
—
—
—
0
0
655
5560
3.26
17.54
17.4
12.6
139.66
139.59
mmol/l
0.37
644
5386
111
467
2.63
17.53
2.1
2.1
—
—
—
0
0
233
1348
2.08
17.46
4.4
4.0
7.40
7.40
ph
0.01
37
255
106
437
2.68
17.43
2.1
2.2
—
—
—
0
0
582
4677
2.35
17.35
5.8
4.8
39.37
38.76
mmol/mol
0.35
543
4375
109
457
2.64
17.33
1.8
2.0
—
—
—
0
0
110
464
2.62
17.27
2.1
2.1
—
—
—
0
0
231
1339
2.07
17.17
2.1
2.0
247.60
272.71
u/l
0.10
212
1264
654
5575
3.16
16.80
17.6
12.7
3.93
3.95
mmol/l
0.74
641
5389
219
1261
2.06
16.46
2.8
2.1
2.71
2.91
mg/l
0.72
189
1075
253
1564
1.96
15.38
2.9
2.5
81.93
62.01
u/l
0.32
233
1444
412
2999
1.89
15.06
5.4
5.3
6.63
6.49
mmol/l
0.63
385
2732
50
146
3.61
14.81
1.2
1.2
—
—
—
0
0
149
768
2.19
14.78
1.5
1.4
498.00
519.73
titre
0.03
20
150
231
1408
1.95
14.47
1.7
1.5
2.23
2.20
g/l
0.12
139
851
109
498
2.40
14.34
2.6
2.4
24.72
32.44
u/l
3.17
86
424
245
1528
1.92
14.30
3.2
3.5
8.60
8.15
mmol/l
0.51
208
1312
128
629
2.26
14.23
1.2
1.2
—
—
—
0
0
47
136
3.63
14.11
1.4
1.4
293.39
277.19
ug/g
0.17
28
75
22
33
6.85
14.09
2.9
2.6
36372.73
40297.12
ug/l
0.40
22
33
154
834
2.08
13.33
2.7
2.5
127.15
115.03
ug/g
0.12
124
664
25
47
5.48
12.85
1.5
2.0
—
—
—
0
0
242
1565
1.83
12.24
1.6
1.4
0.70
1.84
u/ml
2.13
56
391
675
6051
3.28
12.05
12.2
8.9
28.96
27.38
u/l
0.94
660
5841
652
5747
2.62
11.95
16.5
11.3
18.58
21.69
mg/l
1.91
519
4349
85
377
2.43
11.87
2.5
2.3
12.67
14.18
au/ml
—
6
30
451
3531
1.76
11.48
5.0
3.8
1865.10
744.20
e6/l
—
10
45
273
1864
1.75
11.30
4.9
3.6
35.49
88.85
e6/l
1.52
193
1258
134
730
2.03
11.27
2.5
2.8
2.42
2.44
mmol/l
0.61
122
644
470
3735
1.76
11.23
5.1
3.9
—
—
—
0
0
136
761
1.97
10.56
3.5
4.7
0.81
0.82
mmol/l
0.17
120
723
86
404
2.28
10.53
4.9
4.0
—
—
—
0
0
193
1212
1.81
10.49
3.3
3.3
1.02
1.02
kg/l
0.45
27
174
122
664
2.01
10.23
6.2
7.5
1.13
1.11
mmol/l
0.36
114
627
214
1408
1.74
9.83
3.8
3.0
—
—
—
0
0
214
1412
1.74
9.71
7.3
6.6
—
—
—
0
0
229
1543
1.71
9.62
4.1
3.1
14.05
115.01
e6/l
1.49
179
1173
421
3357
1.62
8.88
3.9
3.2
—
—
—
0
0
41
146
2.92
8.84
1.9
2.7
—
—
—
0
0
168
1061
1.76
8.78
3.1
2.6
6.71
6.86
e6/l
0.04
145
930
70
327
2.27
8.67
1.3
1.4
—
—
—
0
0
210
1420
1.68
8.54
3.9
3.0
0.26
0.34
e6/l
0.38
164
1062
52
214
2.54
8.51
1.1
1.1
—
—
—
0
0
296
2187
1.61
8.43
3.4
3.0
6.12
5.85
ph
0.92
25
207
70
332
2.23
8.36
1.1
1.2
—
—
—
0
0
666
6105
2.44
8.08
15.3
10.2
—
—
—
0
0
185
1231
1.68
7.91
4.1
3.3
—
—
—
0
0
110
629
1.89
7.90
3.0
3.4
6.93
8.89
umol/l
0.59
91
542
604
5359
1.84
7.86
4.8
4.1
2.75
2.80
mmol/l
0.81
562
4994
162
1042
1.72
7.85
3.2
2.6
536.18
555.71
mosm/kgh2o
0.47
129
885
97
535
1.94
7.76
1.3
1.3
—
—
—
0
0
80
412
2.06
7.75
7.2
7.5
7.42
7.41
ph
—
6
40
231
1642
1.60
7.55
4.4
3.1
29.94
34.05
ng/l
0.16
141
962
333
2582
1.54
7.40
10.7
8.9
0.00
0.00
e9/l
0.49
267
2087
69
342
2.13
7.39
5.0
3.4
4.60
4.77
pmol/l
0.75
57
304
88
480
1.95
7.26
2.9
2.2
11.45
13.03
nmol/l
0.99
82
442
145
932
1.70
6.98
1.4
1.2
18.03
27.02
iu/ml
1.12
43
292
80
428
1.98
6.98
7.8
9.4
6.79
7.84
mmol/l
0.90
74
411
85
465
1.94
6.95
2.1
3.0
10.61
10.17
g/l
0.43
74
422
266
1983
1.55
6.95
10.6
10.3
1.13
1.20
inr
0.77
74
617
156
1033
1.65
6.69
3.5
3.5
1239.63
1004.93
ng/l
0.15
120
854
188
1310
1.59
6.54
4.8
4.4
93.17
92.03
%
0.26
182
1280
71
373
2.00
6.52
2.0
1.8
1.06
1.35
g/l
1.14
59
345
101
598
1.80
6.46
1.7
1.4
—
—
—
0
0
14
19
7.49
6.43
1.8
2.1
14.76
17.57
umol/l
0.40
14
19
69
363
2.00
6.31
1.1
1.2
—
118.00
—
0
7
25
83
3.09
6.13
1.8
1.6
—
—
—
0
0
135
882
1.65
6.06
1.3
1.2
16.42
8.36
u/ml
0.46
45
350
590
5305
1.66
6.00
4.5
3.8
4.55
4.66
mmol/l
1.91
554
4987
335
2679
1.47
6.00
3.9
3.2
0.00
0.00
estimate
0.50
69
549
588
5283
1.65
5.99
4.4
3.7
1.45
1.44
mmol/l
0.04
547
4943
41
179
2.37
5.97
1.3
1.5
260.83
230.56
u/ml
0.32
24
99
94
559
1.79
5.92
1.4
1.2
—
—
—
0
0
19
54
3.59
5.91
1.3
1.4
2.81
2.57
g/l
0.19
14
34
19
54
3.59
5.91
1.4
1.4
—
—
—
0
0
261
1994
1.49
5.84
2.2
2.0
—
—
—
0
0
62
324
2.00
5.79
7.7
8.0
—
—
—
0
0
15
27
5.65
5.71
2.6
4.9
64.83
167.47
umol/l
—
6
15
335
2701
1.45
5.63
4.0
3.2
0.00
0.00
estimate
-0.00
65
504
35
146
2.47
5.63
1.5
1.9
406.54
463.78
mg/l
0.48
35
139
169
1188
1.55
5.56
5.3
4.0
—
—
—
0
0
122
798
1.64
5.42
3.8
2.8
3.45
2.53
e6/l
0.31
68
432
331
2681
1.44
5.34
5.4
4.4
0.00
0.00
estimate
-0.00
68
534
27
102
2.71
5.30
1.3
1.8
0.57
0.81
g/l
0.67
19
76
21
69
3.11
5.26
1.9
2.7
—
—
—
0
0
62
336
1.93
5.23
4.0
4.8
82.96
71.94
ng/l
0.38
55
311
18
54
3.39
5.19
1.3
1.4
0.37
0.37
g/l
0.01
13
32
18
54
3.39
5.19
1.3
1.4
7.21
6.69
g/l
0.29
13
34
693
6617
2.87
5.07
24.5
16.4
260.76
255.40
e9/l
1.38
679
6438
693
6625
2.82
4.90
24.3
16.3
30.07
30.01
pg
0.40
686
6534
693
6625
2.82
4.90
24.3
16.3
89.94
89.68
fl
0.77
686
6535
693
6626
2.81
4.88
24.4
16.4
4.59
4.59
e12/l
0.01
680
6435
19
62
3.12
4.82
1.7
3.2
41.56
35.64
%
0.86
19
62
693
6629
2.79
4.81
24.5
16.4
6.95
6.75
e9/l
1.83
678
6438
170
1231
1.50
4.81
2.8
2.8
352.84
5910.60
umol/l
4.18
146
1086
25
96
2.66
4.77
3.8
3.4
—
—
—
0
0
693
6632
2.77
4.75
24.6
16.5
137.14
136.95
g/l
0.12
687
6539
32
139
2.36
4.75
1.5
1.9
11.15
9.07
e6/l
0.08
26
108
166
1200
1.50
4.73
3.5
3.5
51.41
121.83
mg/l
0.65
110
785
692
6620
2.70
4.71
24.3
16.6
40.81
41.34
%
0.32
661
6260
13
26
5.07
4.65
1.2
1.5
1.26
8.55
nmol/l
—
8
21
17
53
3.26
4.64
2.6
2.8
—
—
—
0
0
58
322
1.87
4.57
1.1
1.2
—
—
—
0
0
172
1264
1.48
4.50
4.2
4.0
9.63
9.77
mg/mmol
0.02
111
811
79
484
1.71
4.49
1.3
1.2
85.69
148.70
iu/ml
1.13
18
190
16
49
3.32
4.49
1.2
2.1
32.94
32.63
pg
0.07
16
49
559
5064
1.49
4.46
4.1
3.4
1.41
1.26
mmol/l
2.77
515
4734
158
1152
1.48
4.28
2.1
2.1
0.98
1.21
mg/l
0.65
113
859
104
693
1.59
4.27
2.0
2.1
—
—
—
0
0
568
5184
1.48
4.15
19.6
14.0
14.64
14.33
%
0.66
561
5095
81
511
1.66
4.14
2.9
3.5
1.76
1.66
%
0.43
68
458
28
123
2.33
4.08
1.6
2.0
—
—
—
0
0
15
47
3.24
4.07
1.3
1.9
—
—
—
0
0
177
1333
1.44
4.03
1.8
1.7
1.51
1.38
mmol/l
1.10
153
1134
11
22
5.06
4.01
1.9
2.7
—
—
—
0
0
37
184
2.07
4.01
1.0
1.1
1.21
9.83
u/ml
—
8
24
186
1421
1.42
3.90
2.8
2.5
—
—
—
0
0
60
358
1.74
3.77
3.7
5.5
0.05
0.04
%
0.07
20
101
119
840
1.50
3.76
3.2
3.2
98.14
700.59
ng/l
2.23
77
561
74
468
1.65
3.76
5.7
10.9
—
—
—
0
0
16
55
2.95
3.75
1.9
2.4
—
—
—
0
0
23
97
2.42
3.68
2.2
6.7
—
—
—
0
0
37
192
1.98
3.60
1.2
1.2
—
—
—
0
0
186
1441
1.39
3.57
4.0
3.4
0.00
0.01
estimate
0.69
63
520
55
327
1.74
3.51
1.4
1.4
—
—
—
0
0
78
510
1.59
3.48
4.5
5.8
2.20
1.53
mmol/l
0.96
65
406
125
911
1.45
3.36
1.8
1.6
—
—
—
0
0
44
248
1.83
3.36
1.5
2.8
—
—
—
0
0
83
556
1.56
3.34
3.7
8.2
103.75
104.40
mmol/l
0.57
83
556
36
192
1.92
3.26
1.6
1.6
—
—
—
0
0
16
60
2.71
3.24
1.3
1.3
—
—
—
0
0
13
39
3.38
3.23
2.8
3.2
—
—
—
0
0
206
1646
1.35
3.23
2.5
2.3
—
—
—
0
0
23
104
2.25
3.19
4.7
2.6
1.96
2.27
mmol/l
0.19
17
57
56
345
1.68
3.17
5.9
3.9
1.23
1.23
mmol/l
0.29
45
311
46
269
1.76
3.13
1.5
1.7
5.24
7.87
u/l
2.13
32
222
73
483
1.57
3.11
2.8
2.8
0.23
0.22
g/l
0.26
68
451
94
659
1.49
3.08
1.7
1.9
—
—
—
0
0
156
1201
1.38
3.07
3.5
3.1
—
—
—
0
0
23
452
0.49
2.92
1.5
1.3
—
—
—
0
0
70
468
1.55
2.86
4.3
10.6
1.67
0.97
mmol/l
0.83
59
378
35
194
1.85
2.85
3.9
5.7
0.24
0.35
g/l
0.73
17
101
93
663
1.46
2.81
1.8
1.6
—
—
—
0
0
12
39
3.11
2.78
2.1
1.2
—
—
—
0
0
30
160
1.91
2.75
1.2
1.3
—
—
—
0
0
55
353
1.60
2.68
2.3
3.2
68.79
67.39
e9/l
0.12
41
256
7
15
4.70
2.60
2.4
1.8
—
—
—
0
0
211
1740
1.30
2.59
2.4
2.0
—
—
—
0
0
59
392
1.55
2.50
3.8
5.3
0.64
1.03
%
0.70
22
137
21
103
2.07
2.44
1.0
1.0
2.56
2.99
u/ml
0.12
12
40
56
372
1.55
2.39
3.9
5.5
0.00
0.13
%
3.06
18
117
29
161
1.84
2.38
1.5
1.6
—
—
—
0
0
39
237
1.68
2.37
2.8
6.7
—
—
—
0
0
54
359
1.55
2.30
3.4
5.0
0.63
0.51
%
0.11
16
113
35
212
1.68
2.17
2.3
2.2
—
—
—
0
0
20
101
2.01
2.17
3.1
3.6
52.55
54.73
%
0.29
20
101
186
1544
1.28
2.13
3.9
2.8
—
—
—
0
0
48
317
1.55
2.12
3.8
2.1
—
—
—
0
0
7
20
3.52
2.06
1.1
1.4
131.14
139.50
nmol/l
—
7
20
13
56
2.35
2.06
2.3
1.5
—
—
—
0
0
58
403
1.48
2.04
1.6
1.4
—
—
—
0
0
19
97
1.99
2.02
2.3
3.3
4.13
3.96
e9/l
0.12
19
97
29
171
1.73
1.99
1.3
1.2
—
—
—
0
0
44
291
1.55
1.95
1.0
1.1
—
—
—
0
0
36
227
1.62
1.94
1.3
1.3
—
—
—
0
0
13
58
2.26
1.91
2.1
4.7
—
—
—
0
0
13
59
2.23
1.85
1.5
3.0
3.82
93.53
nmol/l
0.49
13
59
6
17
3.55
1.84
1.2
1.3
112.62
70.06
nmol/24h
—
6
17
5
12
4.19
1.82
1.2
1.1
87.26
73.83
ug/l
—
5
12
81
613
1.36
1.79
1.3
1.2
—
—
—
0
0
79
596
1.37
1.79
1.5
1.5
—
—
—
0
0
287
2546
1.21
1.75
2.5
2.6
—
—
—
0
0
9
36
2.52
1.74
1.0
1.1
—
—
—
0
0
5
13
3.86
1.71
1.8
2.1
2.30
1.72
nmol/l
—
5
13
11
48
2.31
1.71
2.0
2.8
—
—
—
0
0
20
111
1.83
1.70
1.1
1.1
376.80
93.85
iu/ml
—
5
33
24
141
1.73
1.70
2.7
2.0
12.75
11.55
mg/l
0.33
24
131
151
1255
1.26
1.70
2.4
2.3
—
—
—
0
0
25
149
1.70
1.69
1.4
1.6
122.70
99.15
u/ml
—
10
20
52
370
1.44
1.65
3.5
3.2
—
—
—
0
0
46
320
1.47
1.64
1.4
1.6
20.75
20.91
iu/l
0.01
31
271
164
1381
1.24
1.64
3.8
4.2
2.19
2.13
ug/l
0.03
147
1245
36
238
1.54
1.63
3.8
9.2
24.82
24.33
mmol/l
0.46
36
223
10
42
2.40
1.62
1.4
1.5
4.33
5.92
ug/l
—
10
34
20
113
1.79
1.62
2.2
1.4
—
—
—
0
0
6
20
3.02
1.58
1.0
1.8
5.87
4.45
nmol/l
—
6
20
10
44
2.29
1.56
1.5
1.3
1.15
1.54
nmol/l
—
10
37
5
15
3.35
1.52
1.0
1.3
—
—
—
0
0
53
386
1.40
1.50
1.8
2.4
4.15
5.61
e9/l
0.72
40
334
12
59
2.05
1.44
1.3
1.3
—
—
nmol/l
—
0
0
5
16
3.14
1.44
1.6
1.5
—
—
—
0
0
57
424
1.37
1.44
2.1
2.3
4037.53
3315.54
u/l
0.08
15
172
41
288
1.45
1.42
2.5
3.0
91.46
156.29
ng/l
1.46
34
258
13
67
1.96
1.39
1.3
1.3
0.57
0.55
nmol/l
0.08
13
61
64
490
1.34
1.36
4.2
3.2
—
—
—
0
0
9
43
2.11
1.30
2.0
1.2
—
—
—
0
0
16
91
1.78
1.30
1.7
1.7
—
—
—
0
0
73
574
1.30
1.29
1.4
1.3
—
—
—
0
0
11
55
2.02
1.28
1.5
3.1
—
—
—
0
0
30
205
1.48
1.22
2.3
5.1
0.54
0.66
%
1.84
30
205
5
19
2.64
1.22
5.2
3.1
—
—
—
0
0
8
37
2.18
1.21
1.0
1.4
1.63
1.80
mmol/l
—
8
37
29
197
1.49
1.21
1.4
1.1
—
—
—
0
0
55
421
1.33
1.19
4.5
11.4
94.50
96.33
%
0.86
55
405
6
26
2.32
1.19
1.5
2.5
9.02
8.88
mmol/l
—
6
26
8
39
2.06
1.15
1.1
1.1
—
—
—
0
0
5
20
2.51
1.15
6.2
2.1
—
—
—
0
0
17
103
1.67
1.13
1.7
1.5
11.17
19.25
u/l
0.68
12
87
8
40
2.01
1.12
1.0
1.2
—
—
—
0
0
60
756
0.77
1.11
1.2
1.3
—
—
—
0
0
19
120
1.60
1.09
3.0
1.9
—
—
—
0
0
11
59
1.88
1.08
1.8
1.4
282.33
290.32
mosm/kgh2o
—
6
44
10
52
1.94
1.06
1.2
1.2
—
—
—
0
0
9
46
1.97
1.04
2.0
2.0
—
—
—
0
0
5
22
2.28
1.03
1.8
2.3
1.76
4.46
ug/l
—
5
22
10
53
1.90
1.01
1.1
1.4
148.35
184.94
pmol/l
—
10
53
30
215
1.41
0.99
1.6
1.5
—
—
—
0
0
32
234
1.38
0.95
12.3
10.0
8.93
9.18
kpa
0.37
32
227
6
27
2.23
0.93
2.7
2.4
532.33
508.06
min
—
6
16
6
28
2.15
0.91
1.3
5.0
—
7.43
—
0
7
6
28
2.15
0.91
1.2
1.8
1.21
1.28
nmol/l
—
6
21
24
169
1.43
0.88
7.3
8.9
—
—
—
0
0
8
44
1.83
0.86
3.3
10.9
10.88
11.76
%
—
8
44
12
72
1.68
0.85
1.2
1.8
—
—
—
0
0
6
31
1.94
0.84
2.3
2.1
308.67
801.61
u/ml
—
6
31
17
248
0.68
0.82
1.4
1.4
—
—
—
0
0
6
32
1.88
0.82
1.0
1.0
—
—
—
0
0
80
940
0.83
0.81
1.5
1.5
—
—
—
0
0
13
81
1.62
0.81
3.5
3.4
—
—
—
0
0
8
47
1.71
0.81
1.6
1.6
—
—
—
0
0
17
247
0.68
0.80
1.4
1.4
—
—
—
0
0
16
106
1.52
0.79
1.1
1.1
—
—
—
0
0
14
90
1.57
0.78
3.5
2.8
17.43
16.00
%
—
7
47
0
27
0.00
0.77
0.0
1.0
—
—
—
0
0
6
34
1.77
0.76
1.5
1.2
—
—
—
0
0
6
34
1.77
0.76
2.7
2.3
571.83
562.50
ml
—
6
18
21
149
1.42
0.76
3.3
5.3
—
—
—
0
0
10
59
1.70
0.76
1.8
1.2
—
—
—
0
0
5
24
2.09
0.74
1.4
5.1
—
—
—
0
0
7
38
1.85
0.73
2.3
1.4
74.43
75.95
umol/l
—
7
38
18
253
0.70
0.73
1.5
1.5
—
—
—
0
0
7
40
1.76
0.71
5.6
3.3
0.81
0.93
nmol/l
—
7
29
5
26
1.93
0.70
1.8
3.3
—
—
—
0
0
48
395
1.23
0.66
4.4
10.6
125.77
122.34
g/l
0.49
48
384
5
28
1.79
0.66
2.4
3.3
2.64
2.67
mmol/l
—
5
20
5
28
1.79
0.66
5.0
7.8
—
—
—
0
0
13
87
1.50
0.63
1.5
1.2
—
—
—
0
0
19
138
1.39
0.63
3.7
2.6
—
—
—
0
0
10
63
1.60
0.62
1.3
1.3
—
—
—
0
0
194
2093
0.90
0.61
2.7
2.4
—
—
—
0
0
15
105
1.44
0.60
1.9
2.7
136.40
128.13
g/l
—
10
79
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
8
54
1.49
0.57
1.3
1.4
—
—
—
0
0
11
73
1.51
0.56
1.6
2.0
—
—
—
0
0
12
82
1.47
0.54
1.1
1.0
—
—
—
0
0
6
38
1.58
0.54
1.7
5.1
—
117.48
—
0
14
90
801
1.14
0.53
2.6
2.7
0.62
0.73
ug/l
0.89
58
480
23
183
1.27
0.45
2.1
2.1
1.63
1.37
g/l
0.57
18
151
12
86
1.40
0.44
3.2
4.9
—
—
—
0
0
5
31
1.62
0.43
1.8
2.0
—
—
—
0
0
5
31
1.62
0.43
1.2
1.1
118.62
191.35
iu/ml
—
5
31
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
6.3
—
—
—
0
0
100
1091
0.90
0.40
2.1
1.8
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
7
104
0.67
0.39
1.6
1.2
—
—
—
0
0
8
112
0.71
0.37
2.0
3.9
—
—
—
0
0
28
235
1.20
0.36
5.1
15.2
—
—
—
0
0
11
81
1.36
0.36
1.4
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
6
44
1.37
0.34
2.2
3.3
—
—
—
0
0
10
74
1.36
0.32
1.1
1.3
0.49
3.39
u/ml
—
5
36
32
277
1.16
0.31
1.3
1.4
222.21
245.29
miu/ml
0.09
12
140
13
103
1.27
0.28
1.7
1.1
—
—
—
0
0
11
86
1.28
0.26
1.9
4.8
—
—
—
0
0
5
72
0.69
0.26
1.0
1.0
12.26
8.67
mu/l
—
5
67
133
1401
0.94
0.26
1.8
1.7
—
—
—
0
0
5
39
1.28
0.23
1.4
2.9
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
6631.91
—
0
11
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.25
0.20
2.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
63.22
—
0
9
0
14
0.00
0.20
0.0
8.6
—
—
—
0
0
6
51
1.18
0.19
1.0
1.0
—
—
—
0
0
18
207
0.87
0.19
1.1
1.2
4.89
2.88
u/ml
—
9
129
7
60
1.17
0.18
1.4
1.7
—
—
—
0
0
12
142
0.84
0.17
1.0
1.1
—
—
—
0
0
16
182
0.88
0.15
1.1
1.1
2.70
1.81
u/ml
—
6
104
14
121
1.16
0.15
1.1
1.1
1.18
5.39
u/ml
—
7
64
13
113
1.15
0.13
1.8
4.5
36.10
29.50
mg/l
—
7
89
13
113
1.15
0.13
1.8
4.5
49.59
99.96
mg/l
—
7
88
9
107
0.84
0.13
1.1
1.5
—
—
—
0
0
36
337
1.07
0.11
2.8
2.4
2.46
7.80
ug/l
5.34
27
303
185
1890
0.97
0.11
1.5
1.6
—
—
—
0
0
10
86
1.17
0.11
1.6
1.6
—
—
—
0
0
5
46
1.09
0.09
2.8
1.5
0.70
1.02
g/l
—
5
46
16
176
0.91
0.09
1.1
1.1
0.25
2.55
u/ml
—
8
110
10
87
1.15
0.09
2.5
11.6
11.40
11.08
mmol/l
—
10
76
5
47
1.06
0.09
1.4
1.1
—
—
—
0
0
6
55
1.09
0.09
1.7
1.2
—
—
—
0
0
10
88
1.14
0.08
1.2
1.3
—
—
—
0
0
10
88
1.14
0.08
2.5
11.5
106.30
105.53
mmol/l
—
10
77
11
98
1.12
0.07
1.0
1.1
—
—
—
0
0
13
143
0.91
0.07
1.0
1.1
—
—
—
0
0
11
121
0.91
0.06
1.2
1.2
—
—
—
0
0
10
107
0.93
0.02
1.0
1.1
—
—
—
0
0
18
187
0.96
0.01
1.1
1.1
2.25
6.39
u/ml
2.05
11
125
10
96
1.04
0.00
2.4
2.6
—
—
—
0
0
38
382
0.99
0.00
2.7
4.7
3.52
19.55
ug/l
0.79
33
307
14
139
1.01
0.00
1.1
1.1
0.40
5.49
u/ml
—
6
79
22
219
1.00
0.00
2.5
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.1
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
16.58
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
34.60
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
32
320
1.00
-0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
237.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
15.0
—
110.17
—
0
6
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_SLEEPWAKE and mortality.

Females

Parameter HR [95% CI] p-value
F5_SLEEPWAKE 2.192 [1.67, 2.88] < 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 2225 females with F5_SLEEPWAKE died.

Males

Parameter HR [95% CI] p-value
F5_SLEEPWAKE 2.046 [1.64, 2.55] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 2839 males with F5_SLEEPWAKE died.

Mortality risk

Mortality risk for people of age

years, who have F5_SLEEPWAKE.

N-year risk Females Males
1 0.236% 0.3%
5 1.1% 2.454%
10 2.53% 6.216%
15 4.99% 11.799%
20 8.937% 19.409%

Relationships between endpoints

↥

Index endpoint: F5_SLEEPWAKE – Disorder of the sleep-wake schedule

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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