Disorder of the sleep-wake schedule

F5_SLEEPWAKE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F51.2, G47.2
  • Hospital discharge: ICD-9 3074F
  • Cause of death: ICD-10 F51.2, G47.2
  • Cause of death: ICD-9 3074F

2 out of 7 registries used, show all original rules.

661

4. Check minimum number of events

None

661

5. Include endpoints

None

661

6. Filter based on genotype QC (FinnGen only)

661

Control definitions (FinnGen only)

Control exclude
F5_SLEEP

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6901 3035 3847
Only index persons 5380 2449 2931
Unadjusted period prevalence (%)
Whole population 0.10 0.09 0.11
Only index persons 0.10 0.09 0.11
Median age at first event (years)
Whole population 17.72 18.07 17.36
Only index persons 23.48 23.54 23.43

-FinnGen-

Key figures

All Female Male
Number of individuals 661 358 303
Unadjusted period prevalence (%) 0.13 0.12 0.13
Median age at first event (years) 41.67 37.75 46.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
579
Matched controls
5789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G47.2
ICD-10 Finland
Disorders of the sleep-wake schedule
2785.7
323.0
285
*
F51.2
ICD-10 Finland
Nonorganic disorder of the sleep-wake schedule
555.7
294.0
269
9
G47.3
ICD-10 Finland
Sleep apnoea
5.9
70.2
242
627
N05AH04
ATC
quetiapine; oral
5.8
65.7
224
564
N06AX11
ATC
mirtazapine; oral
4.4
55.6
272
972
F51.0
ICD-10 Finland
Nonorganic insomnia
6.4
55.1
163
333
IAB13
NOMESCO Finland
Psychiatric sleep disorder consultation
519.5
49.1
48
*
G47.9
ICD-10 Finland
Sleep disorder, unspecified
15.2
37.6
63
46
N05CF01
ATC
zopiclone; oral
3.6
37.1
216
828
3074F
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Specific disorders of sleep of nonorganic origin[UNIVALVERYTMIN HÄIRIÖ]
+∞
36.9
35
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.1
33.7
152
464
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.3
33.1
137
385
IEY18
NOMESCO Finland
Psychiatric sleep coaching, individual
+∞
29.4
28
*
N06AX12
ATC
bupropion; oral
5.1
29.4
99
223
N06AX05
ATC
trazodone; oral
14.4
28.8
49
37
N05BA04
ATC
oxazepam; oral
3.2
28.0
183
736
N06AB10
ATC
escitalopram; oral
3.1
27.2
180
729
N06AX16
ATC
venlafaxine; oral
3.7
27.1
136
447
F51.9
ICD-10 Finland
Nonorganic sleep disorder, unspecified
15.8
26.9
44
30
N05AH03
ATC
olanzapine; systemic
5.6
25.9
79
158
N06AB04
ATC
citalopram; systemic
3.1
24.8
159
625
N03AX16
ATC
pregabalin; oral
3.1
24.5
160
634
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
12.8
23.7
42
35
G47.0
ICD-10 Finland
Disorders of initiating and maintaining sleep [insomnias]
13.8
23.3
40
31
N06AB03
ATC
fluoxetine; oral
3.6
23.1
115
371
R5140
NOMESCO Finland
Monitoring the use of the aid
4.3
23.1
93
249
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.0
23.0
58
90
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
6.5
22.8
61
103
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.3
22.4
88
230
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
8.5
21.7
48
61
F61.0
ICD-10 Finland
Mixed personality disorders
10.2
21.7
43
45
N03AX09
ATC
lamotrigine; oral
5.5
21.6
66
132
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.9
21.3
73
166
N05CF02
ATC
zolpidem; oral
3.2
20.9
127
472
R40.0
ICD-10 Finland
Somnolence
217.5
20.7
21
*
N06AB06
ATC
sertraline; oral
3.5
20.5
105
345
P06
ICPC
Sleep disturbance
3.6
19.4
95
301
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.4
19.3
102
343
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
8.1
19.0
43
57
N06BA04
ATC
methylphenidate; oral
5.7
18.7
55
105
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.4
18.4
98
331
F34.1
ICD-10 Finland
Dysthymia
6.0
18.3
51
91
R06.5
ICD-10 Finland
Mouth breathing
3.7
18.3
86
263
N05BA01
ATC
diazepam; systemic, rectal
3.4
18.2
96
322
N03AG01
ATC
valproic acid; systemic, rectal
5.0
17.3
57
124
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
6.8
17.1
43
67
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
5.8
17.0
49
91
R53
ICD-10 Finland
Malaise and fatigue
2.6
16.9
140
629
N05AX12
ATC
aripiprazole; systemic
5.0
16.6
54
116
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.7
16.5
58
135
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
5.6
16.3
48
92
N03AE01
ATC
clonazepam; systemic
5.1
16.2
52
110
N06AX03
ATC
mianserin; oral
6.7
16.1
41
65
N06AX22
ATC
agomelatine; oral
8.4
16.0
35
44
P03
ICPC
Feeling depressed
2.9
16.0
107
421
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.9
16.0
69
196
N04BC05
ATC
pramipexole; oral
4.8
15.8
53
118
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.1
15.6
91
325
N06AB05
ATC
paroxetine; oral
4.4
15.4
57
140
F41.1
ICD-10 Finland
Generalized anxiety disorder
4.3
15.4
58
145
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
10.1
15.4
30
31
N05CD07
ATC
temazepam; oral
3.9
15.3
65
182
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.4
15.2
56
137
N06AX21
ATC
duloxetine; oral
3.3
15.1
83
283
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.7
15.0
52
120
P76
ICPC
Depressive disorder
3.5
14.8
73
231
N06AX26
ATC
vortioxetine; oral
4.0
14.8
61
166
N05AA02
ATC
levomepromazine; systemic
5.7
14.2
41
77
N06AA09
ATC
amitriptyline; systemic
3.6
14.1
66
201
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
7.0
13.9
34
51
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
20.7
13.9
20
10
N03AX12
ATC
gabapentin; oral
2.7
13.8
100
410
A02BC02
ATC
pantoprazole; systemic
2.0
13.6
326
2303
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
13.6
228
1403
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
6.1
13.4
36
62
C07AA05
ATC
propranolol; systemic
2.4
13.1
125
597
WX722
NOMESCO Finland
PEEP
4.7
13.0
44
99
N05AX08
ATC
risperidone; systemic
3.6
12.9
60
182
R03AC02
ATC
salbutamol; inhalant
1.9
12.6
314
2224
XG466
NOMESCO Finland
Sleep oxymetry
5.4
12.5
37
72
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.8
11.8
33
60
M79.6
ICD-10 Finland
Pain in limb
2.0
11.8
189
1129
IGY02
NOMESCO Finland
Psychiatric monitoring contact
4.8
11.6
38
83
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.7
11.6
39
88
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
11.3
155
867
N06AA12
ATC
doxepin; systemic
4.9
11.1
36
78
IGY99
NOMESCO Finland
Other psychiatric treatment contact
5.5
11.1
32
61
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.2
11.0
41
102
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
10.9
66
241
R06.0
ICD-10 Finland
Dyspnoea
2.2
10.8
130
684
R03BA05
ATC
fluticasone; inhalant
2.2
10.7
124
646
N05BE01
ATC
buspirone; oral
5.4
10.3
30
58
R52.9
ICD-10 Finland
Pain, unspecified
3.0
10.3
59
209
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.7
10.2
34
76
WX723
NOMESCO Finland
CPAP therapy
4.7
10.2
34
76
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
10.2
128
686
IBA03
NOMESCO Finland
Psychotherapy evaluation
8.7
10.1
21
25
P74
ICPC
Anxiety disorder/anxiety state
3.4
10.1
49
154
M79.7
ICD-10 Finland
Fibromyalgia
4.9
10.1
32
68
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
6.0
10.1
27
47
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
10.0
112
572
A02BC05
ATC
esomeprazole; systemic
1.8
10.0
202
1301
F33
ICD-10 Finland
Recurrent depressive disorder
6.1
9.9
26
44
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
7.6
9.8
22
30
P99
ICPC
Psychological disorders other
4.7
9.7
32
71
G47.1
ICD-10 Finland
Disorders of excessive somnolence [hypersomnias]
55.9
9.7
11
*
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
11.6
9.6
17
15
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
9.5
106
538
R03DC03
ATC
montelukast; oral
2.2
9.5
104
526
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
8.9
9.3
19
22
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.9
9.3
58
216
D11
ICPC
Diarrhoea
2.3
9.3
90
429
P29
ICPC
Psychological sympt/compl other
2.8
9.2
61
236
N05AF03
ATC
chlorprothixene; systemic
4.9
9.2
29
62
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
9.1
74
323
R51.80
ICD-10 Finland
Headache
2.2
9.1
105
540
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.7
9.1
61
239
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
5.6
9.0
25
46
F60.9
ICD-10 Finland
Personality disorder, unspecified
7.6
9.0
20
27
C03CA01
ATC
furosemide; systemic
2.2
8.9
100
511
L01
ICPC
Neck symptom/complaint
2.2
8.7
90
442
R01AD09
ATC
mometasone; nasal
1.7
8.6
256
1833
A04
ICPC
Weakness/tiredness general
2.2
8.6
91
452
N02AX02
ATC
tramadol; systemic, rectal
1.8
8.5
205
1379
F31.8
ICD-10 Finland
Other bipolar affective disorders
5.8
8.5
23
41
A02BC03
ATC
lansoprazole; oral
1.9
8.5
130
750
N05AB03
ATC
perphenazine; systemic, rectal
5.0
8.5
26
54
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.8
8.5
53
199
E66.00
ICD-10 Finland
Metabolic syndrome
3.5
8.4
38
114
F39
ICD-10 Finland
Unspecified mood [affective] disorder
5.4
8.4
24
46
Z29
ICPC
Social problem NOS
5.5
8.2
23
43
A06AD11
ATC
lactulose; oral
2.5
8.2
67
292
H03AA01
ATC
levothyroxine sodium; systemic
2.0
8.1
110
605
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
17.5
8.1
12
7
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
9.1
8.1
16
18
F51
ICD-10 Finland
Nonorganic sleep disorders
3.9
8.1
32
86
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.5
8.0
36
108
F41.09
ICD-10 Finland
UNS Panic Syndrome
3.8
8.0
32
87
J31.0
ICD-10 Finland
Chronic rhinitis
2.6
7.9
55
221
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
5.0
7.8
24
50
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.3
7.8
75
355
SPAT1240
SPAT
Therapeutic discussion
2.1
7.8
90
462
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.8
204
1400
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.2
7.8
39
127
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
7.8
131
783
M25.5
ICD-10 Finland
Pain in joint
1.8
7.7
151
947
M79.1
ICD-10 Finland
Myalgia
2.2
7.7
79
385
L28
ICPC
Limited function/disability (L)
2.3
7.6
70
326
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.6
7.6
33
96
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
7.6
193
1313
N05AB01
ATC
dixyrazine; systemic
10.2
7.6
14
14
L03
ICPC
Low back symptom/complaint
1.8
7.6
137
836
N06AG02
ATC
moclobemide; oral
3.6
7.5
32
92
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.5
7.5
60
258
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
5.2
7.5
22
44
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
6.6
7.5
18
28
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.1
7.5
40
137
N06AA04
ATC
clomipramine; systemic
8.5
7.4
15
18
H02AB06
ATC
prednisolone; systemic
1.7
7.3
224
1600
N05AE04
ATC
ziprasidone; systemic
9.5
7.3
14
15
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
9.5
7.3
14
15
N05AN01
ATC
lithium; oral
4.9
7.2
22
46
N05BA06
ATC
lorazepam; systemic, sublingual
3.6
7.2
31
90
P01
ICPC
Feeling anxious/nervous/tense
2.0
7.1
97
533
N05BA12
ATC
alprazolam; oral
2.5
7.1
55
234
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.0
449
3874
DHB50
NOMESCO Finland
Turbinoplasty
3.9
7.0
27
72
F51.8
ICD-10 Finland
Other nonorganic sleep disorders
14.0
6.9
11
8
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
6.9
88
473
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
6.9
169
1130
E66.8
ICD-10 Finland
Other obesity
3.0
6.8
37
128
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.6
6.8
22
49
H02AB07
ATC
prednisone; oral
2.2
6.8
67
323
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
6.8
140
888
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
6.8
47
188
L02
ICPC
Back symptom/complaint
2.3
6.8
61
280
F51.1
ICD-10 Finland
Nonorganic hypersomnia
40.5
6.8
8
*
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
16.9
6.8
10
6
L29
ICPC
Musculoskeletal sympt/complt other
2.6
6.8
47
189
R52.2
ICD-10 Finland
Other chronic pain
4.0
6.8
25
64
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.6
6.7
48
197
M01AB05
ATC
diclofenac; systemic, rectal
1.6
6.6
324
2585
N06BA07
ATC
modafinil; oral
12.4
6.6
11
9
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
6.5
55
247
N06AA06
ATC
trimipramine; systemic
4.8
6.5
20
43
WX110
NOMESCO Finland
Local anesthesy
1.6
6.4
403
3408
K59.09
ICD-10 Finland
Constipation, unspecified
3.0
6.4
36
126
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
6.4
121
746
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
8.3
6.4
13
16
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.2
6.4
66
326
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
6.3
65
316
J34.2
ICD-10 Finland
Deviated nasal septum
2.8
6.3
38
141
K07.60
ICD-10 Finland
Snapping jaw
2.8
6.3
38
141
A28
ICPC
Limited function/disability NOS
2.3
6.3
58
269
N06BA12
ATC
lisdexamfetamine; oral
9.4
6.3
12
13
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.1
6.3
68
342
N03AX11
ATC
topiramate; oral
4.4
6.3
21
49
G47.8
ICD-10 Finland
Other sleep disorders
7.1
6.2
14
20
WX780
NOMESCO Finland
Remote monitoring CPAP
3.4
6.2
28
85
M54.5
ICD-10 Finland
Low back pain
1.6
6.2
170
1166
G47.4
ICD-10 Finland
Narcolepsy and cataplexy
27.0
6.2
8
*
SPAT1051
SPAT
Guidance regarding sleep disorders
5.4
6.2
17
32
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.8
6.2
118
732
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.1
6.1
31
103
R06AE07
ATC
cetirizine; oral
1.6
6.1
242
1821
F32.1
ICD-10 Finland
Moderate depressive episode
2.6
6.1
43
174
K59.0
ICD-10 Finland
Constipation
3.3
6.1
29
92
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.1
122
765
G44.2
ICD-10 Finland
Tension-type headache
2.0
6.1
74
388
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
8.7
6.1
12
14
D01
ICPC
Abdominal pain/cramps general
2.0
6.0
74
391
R05
ICPC
Cough
1.7
6.0
126
801
C07AB07
ATC
bisoprolol; oral
1.6
6.0
180
1265

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
180
711
3.11
33.80
2.5
2.4
14.3
14.1
umol/l
0.15
167
654
312
1680
2.63
32.09
2.2
1.8
96.1
95.7
pmol/l
0.05
175
884
165
650
3.05
30.85
2.4
2.4
2.4
2.4
g/l
0.00
153
596
154
599
3.05
29.32
2.5
2.5
23.3
23.9
%
0.19
139
523
350
2051
2.50
29.31
6.5
7.7
1.2
1.2
mmol/l
2.07
322
1878
281
1488
2.55
29.29
2.7
3.2
2.4
2.4
mmol/l
0.16
257
1332
205
951
2.68
27.86
1.7
1.4
18.8
20.2
nmol/l
0.85
184
807
76
196
4.25
27.01
2.3
2.3
—
—
—
0
0
515
3708
2.77
26.50
7.7
7.1
80.4
81.1
u/l
0.13
493
3475
338
2038
2.35
25.39
2.8
2.4
72.5
73.3
nmol/l
0.20
315
1851
362
2248
2.35
25.38
7.0
7.8
1.2
1.2
mmol/l
2.45
309
1915
157
674
2.74
24.52
2.0
1.7
1068.6
1141.0
nmol/l
0.44
121
509
531
4035
2.62
21.75
5.0
3.7
14.5
14.6
pmol/l
0.38
491
3668
125
519
2.74
20.55
2.4
2.2
406.9
373.0
nmol/l
0.87
114
486
301
1877
2.11
19.17
5.1
5.4
36.5
36.5
g/l
0.01
278
1754
495
3770
2.25
18.08
4.8
3.8
9.9
9.9
mm/h
0.01
471
3472
285
1784
2.05
17.55
6.6
6.2
—
—
—
0
0
423
3054
2.07
17.46
9.7
8.9
4.1
4.0
e9/l
0.63
366
2657
163
825
2.30
17.30
1.8
1.7
47328669.8
19236638.1
pmol/l
0.24
131
707
366
2523
2.01
17.02
3.8
2.7
95.1
98.0
ug/l
0.14
339
2339
389
2754
2.00
16.60
6.5
6.5
0.2
0.2
e9/l
0.26
343
2443
89
349
2.79
16.16
2.1
2.0
—
—
—
0
0
357
2475
1.96
15.95
5.9
6.4
12.0
13.8
umol/l
0.99
328
2331
350
2430
1.94
15.36
6.9
6.4
0.7
0.7
%
0.05
334
2280
376
2674
1.94
15.35
6.3
6.1
0.0
0.0
e9/l
0.13
330
2318
368
2600
1.94
15.30
6.4
6.1
55.3
55.4
%
0.05
351
2457
386
2773
1.94
15.25
6.3
6.1
2.1
2.0
e9/l
0.98
346
2462
374
2662
1.93
15.15
6.3
6.1
0.6
0.6
e9/l
0.74
331
2308
360
2533
1.93
15.07
6.9
6.5
8.2
8.4
%
0.47
346
2388
370
2632
1.92
14.93
6.8
6.2
30.6
30.0
%
0.48
352
2476
78
297
2.84
14.93
3.5
2.7
—
—
—
0
0
357
2521
1.91
14.62
6.7
6.2
2.8
2.9
%
0.42
341
2352
578
4851
2.54
14.53
6.3
4.3
1.8
2.1
mu/l
0.59
540
4482
215
1290
1.99
14.29
4.5
4.0
7.4
7.4
ph
0.14
36
245
239
1496
1.94
13.98
2.9
2.6
53.7
57.6
u/l
0.85
219
1379
213
1287
1.97
13.79
2.2
2.1
260.7
273.8
u/l
0.05
194
1219
93
404
2.52
13.70
2.1
2.0
—
—
—
0
0
202
1203
1.98
13.61
2.9
2.1
2.8
2.9
mg/l
0.54
172
1032
570
4801
2.37
13.39
4.8
3.8
5.9
5.8
mmol/l
0.98
527
4416
137
713
2.16
13.26
1.6
1.4
498.0
480.3
titre
0.02
20
136
97
437
2.43
13.19
2.1
2.0
—
—
—
0
0
96
432
2.43
13.09
2.1
2.0
—
—
—
0
0
96
432
2.43
13.09
1.8
1.9
—
—
—
0
0
96
434
2.42
12.95
2.1
2.0
—
—
—
0
0
605
5257
2.81
12.91
17.9
13.0
139.6
139.6
mmol/l
0.23
594
5097
535
4421
2.11
12.75
5.9
4.8
39.7
38.7
mmol/mol
0.60
497
4142
604
5272
2.72
12.23
18.1
13.1
3.9
4.0
mmol/l
0.52
591
5099
124
641
2.15
12.14
1.3
1.2
—
—
—
0
0
384
2879
1.80
11.99
5.5
5.3
6.7
6.5
mmol/l
0.78
358
2638
43
133
3.39
11.70
1.4
1.5
277.5
276.1
ug/g
0.01
26
74
211
1332
1.86
11.62
1.7
1.5
2.2
2.2
g/l
0.04
129
803
224
1448
1.83
11.39
3.3
3.5
8.4
8.3
mmol/l
0.16
187
1235
144
826
1.95
10.50
2.7
2.5
134.1
120.5
ug/g
0.13
116
651
97
481
2.19
10.47
2.5
2.3
24.5
34.9
u/l
2.79
75
405
253
1762
1.71
9.58
5.0
3.7
31.3
88.9
e6/l
1.66
178
1220
220
1480
1.73
9.42
1.6
1.4
0.7
1.6
u/ml
1.94
51
376
128
730
1.93
9.41
3.6
4.5
0.8
0.8
mmol/l
0.05
112
694
624
5667
2.85
9.23
12.4
9.1
29.2
27.5
u/l
0.90
609
5477
418
3350
1.68
9.04
5.2
3.9
2055.0
738.6
e6/l
—
9
41
13
18
7.35
8.87
1.8
2.2
15.2
17.7
umol/l
0.32
13
18
80
396
2.16
8.64
5.2
4.0
—
—
—
0
0
433
3525
1.66
8.60
5.2
3.9
—
—
—
0
0
603
5431
2.28
8.39
17.1
11.6
18.7
21.6
mg/l
1.68
482
4151
113
645
1.91
8.23
6.4
7.7
1.1
1.1
mmol/l
0.37
105
607
177
1163
1.71
8.06
3.5
3.3
1.0
1.0
kg/l
0.14
26
164
159
1015
1.75
8.03
3.1
2.6
6.9
6.8
e6/l
0.03
135
880
213
1472
1.66
8.01
4.3
3.2
14.6
129.6
e6/l
1.70
166
1125
120
705
1.86
7.98
2.7
2.6
2.4
2.4
mmol/l
0.35
108
621
67
319
2.22
7.96
5.1
3.4
4.6
4.7
pmol/l
0.41
55
280
34
117
3.01
7.81
4.8
4.6
37.8
37.7
umol/l
0.01
27
103
153
973
1.75
7.81
3.3
2.6
539.9
565.5
mosm/kgh2o
0.63
121
823
198
1352
1.66
7.76
7.6
6.4
—
—
—
0
0
19
44
4.42
7.72
1.2
1.9
—
—
—
0
0
38
141
2.80
7.64
1.1
1.2
—
—
—
0
0
196
1345
1.65
7.50
3.9
3.0
—
—
—
0
0
66
322
2.17
7.39
1.4
1.4
—
—
—
0
0
36
137
2.72
6.92
2.1
2.9
—
—
—
0
0
194
1354
1.61
6.84
4.1
3.1
0.3
0.3
e6/l
0.39
149
1013
11
17
6.56
6.79
1.9
2.6
—
—
—
0
0
13
24
5.51
6.79
2.3
5.6
43.4
169.1
umol/l
—
5
11
93
531
1.87
6.72
1.3
1.3
—
—
—
0
0
79
437
1.92
6.29
2.1
2.9
10.8
10.2
g/l
0.53
68
396
19
52
3.73
6.24
1.3
1.3
2.8
2.6
g/l
0.19
14
32
19
52
3.73
6.24
1.6
3.8
10.5
14.8
%
—
8
33
68
359
2.00
6.19
2.0
1.8
1.1
1.4
g/l
1.10
57
329
19
53
3.66
6.07
1.4
1.3
—
—
—
0
0
134
881
1.65
5.92
1.4
1.3
18.9
29.5
iu/ml
1.21
40
274
63
329
2.01
5.91
1.1
1.2
—
—
—
0
0
616
5719
2.16
5.90
15.9
10.6
—
—
—
0
0
100
613
1.74
5.71
3.1
3.4
7.1
8.4
umol/l
0.30
83
518
171
1205
1.57
5.65
4.2
3.3
—
—
—
0
0
21
67
3.20
5.51
1.6
3.3
1.1
1.4
e9/l
0.45
16
36
18
52
3.53
5.48
1.3
1.3
7.2
7.0
g/l
0.11
13
33
18
52
3.53
5.48
1.3
1.3
0.4
0.4
g/l
0.03
13
31
556
5028
1.67
5.45
4.8
4.2
2.8
2.8
mmol/l
0.70
517
4669
59
311
1.99
5.41
4.2
5.0
84.0
73.6
ng/l
0.33
52
285
72
409
1.85
5.29
7.7
7.5
7.4
7.4
ph
—
5
40
73
417
1.84
5.27
8.5
9.5
7.1
7.7
mmol/l
0.44
67
402
23
80
2.94
5.24
1.9
1.6
—
—
—
0
0
304
2444
1.45
5.21
11.1
8.9
0.0
0.0
e9/l
0.41
244
1993
162
1147
1.55
5.19
5.4
4.0
—
—
—
0
0
26
98
2.72
5.13
1.3
1.7
0.6
0.9
g/l
0.70
18
74
32
134
2.46
5.13
1.5
1.9
409.0
454.5
mg/l
0.33
32
128
313
2536
1.45
5.11
4.0
3.2
0.0
0.0
estimate
0.00
61
498
76
444
1.80
5.10
1.3
1.2
88.9
156.6
iu/ml
1.14
17
182
386
3254
1.45
5.08
4.0
3.2
—
—
—
0
0
12
27
4.51
5.05
2.1
1.2
—
—
—
0
0
246
1908
1.46
5.05
2.2
2.0
—
—
—
0
0
215
1625
1.48
5.03
4.6
3.1
30.7
43.5
ng/l
0.44
136
952
91
563
1.71
5.02
1.7
1.4
—
—
—
0
0
218
1666
1.46
4.78
6.1
7.1
1.1
1.2
inr
0.15
68
528
59
325
1.90
4.77
4.9
6.7
24.6
23.7
mmol/l
1.39
51
307
124
842
1.58
4.75
1.3
1.3
17.5
9.1
u/ml
0.44
42
338
171
1248
1.50
4.71
4.9
4.3
93.3
92.4
%
0.17
165
1223
61
343
1.86
4.64
1.1
1.2
—
104.5
—
0
8
47
242
2.01
4.62
1.1
1.1
—
—
—
0
0
18
59
3.11
4.54
1.7
3.1
—
37.0
—
0
6
312
2570
1.41
4.44
4.1
3.3
0.0
0.0
estimate
0.00
61
490
113
764
1.58
4.39
3.9
2.9
3.7
2.5
e6/l
0.36
62
417
79
488
1.70
4.39
3.0
2.3
12.1
13.3
nmol/l
0.62
71
441
19
66
2.93
4.36
1.9
2.7
—
—
—
0
0
16
50
3.25
4.36
1.2
1.8
32.9
32.5
pg
0.10
16
50
156
1134
1.49
4.35
3.5
3.5
53.0
136.9
mg/l
0.77
103
752
78
486
1.69
4.20
2.9
3.7
1.8
1.7
%
0.25
65
437
308
2548
1.39
4.20
5.5
4.5
0.0
0.0
estimate
0.50
64
520
56
318
1.83
4.14
8.2
8.1
—
—
—
0
0
542
4958
1.52
4.11
4.4
3.8
1.5
1.4
mmol/l
0.06
505
4623
161
1190
1.47
4.11
4.5
4.2
9.7
11.2
mg/mmol
0.20
102
772
29
130
2.29
4.05
1.6
1.9
12.2
8.1
e6/l
0.16
23
96
543
4978
1.51
3.99
4.5
3.8
4.5
4.7
mmol/l
1.80
510
4668
35
171
2.11
3.98
1.3
1.5
268.9
231.2
u/ml
0.36
20
90
56
325
1.79
3.87
1.1
1.2
—
—
—
0
0
25
107
2.39
3.87
1.6
2.1
—
—
—
0
0
15
49
3.11
3.83
3.0
3.0
—
—
—
0
0
642
6173
2.47
3.73
25.0
16.9
260.9
255.2
e9/l
1.41
628
6018
569
5291
1.55
3.67
17.2
12.5
40.6
40.6
%
0.03
426
4230
642
6180
2.42
3.59
24.9
16.8
30.0
30.1
pg
0.06
636
6103
642
6180
2.42
3.59
24.9
16.8
89.9
89.8
fl
0.12
636
6104
98
672
1.54
3.57
2.1
2.1
—
—
—
0
0
642
6181
2.42
3.57
25.0
16.9
4.6
4.6
e12/l
0.10
630
6018
23
99
2.37
3.54
4.1
3.3
—
—
—
0
0
642
6185
2.39
3.49
25.1
16.9
7.0
6.8
e9/l
1.82
627
6019
642
6186
2.39
3.47
25.2
17.1
137.1
137.1
g/l
0.02
636
6106
82
544
1.58
3.46
1.4
1.2
—
—
—
0
0
58
353
1.71
3.43
3.7
5.3
0.0
0.0
%
0.80
16
90
155
1174
1.42
3.42
2.9
2.8
354.4
6170.0
umol/l
4.18
132
1029
42
232
1.87
3.42
1.5
2.5
—
—
—
0
0
12
37
3.28
3.35
3.0
3.1
—
—
—
0
0
35
183
1.96
3.35
1.2
1.2
—
—
—
0
0
68
438
1.62
3.25
5.5
11.1
—
—
—
0
0
160
1234
1.39
3.17
3.5
4.6
—
—
—
0
0
169
1321
1.38
3.08
2.9
2.6
—
—
—
0
0
22
100
2.24
3.02
2.2
7.0
—
—
—
0
0
67
438
1.59
3.02
3.9
10.6
1.8
0.9
mmol/l
0.99
56
350
34
183
1.90
3.02
1.6
1.6
—
—
—
0
0
20
412
0.47
2.92
1.5
1.3
—
—
—
0
0
15
58
2.62
2.89
1.3
1.2
—
—
—
0
0
54
340
1.64
2.84
2.3
3.3
69.0
67.9
e9/l
0.08
40
246
14
53
2.68
2.81
2.0
2.4
—
—
—
0
0
161
1268
1.36
2.77
1.8
1.7
1.6
1.4
mmol/l
1.03
137
1086
173
1378
1.35
2.77
4.2
3.5
0.0
0.0
estimate
1.08
59
507
77
531
1.51
2.76
3.3
7.9
103.5
104.3
mmol/l
0.68
71
523
515
4770
1.36
2.75
4.1
3.5
1.4
1.3
mmol/l
2.59
475
4455
145
1125
1.37
2.74
2.2
2.1
1.0
1.2
mg/l
0.35
102
830
22
105
2.13
2.71
4.9
2.7
9.4
9.0
kpa
0.42
22
105
22
105
2.13
2.71
4.9
2.7
2.1
2.6
mmol/l
0.31
16
61
22
105
2.13
2.71
4.9
2.7
4.9
4.8
kpa
0.25
22
105
53
337
1.62
2.69
6.2
3.9
1.2
1.2
mmol/l
0.02
43
294
72
493
1.52
2.67
4.6
6.1
2.1
1.6
mmol/l
0.64
59
382
88
630
1.46
2.63
1.8
1.8
—
—
—
0
0
47
292
1.66
2.62
3.9
2.3
—
—
—
0
0
7
15
4.70
2.60
2.4
1.9
—
—
—
0
0
87
623
1.46
2.59
1.9
1.6
—
—
—
0
0
33
188
1.80
2.50
3.8
5.7
0.3
0.3
g/l
0.46
15
98
67
460
1.51
2.46
2.8
2.8
0.2
0.2
g/l
0.16
62
430
49
313
1.61
2.46
1.4
1.4
—
—
—
0
0
13
51
2.58
2.45
2.3
1.5
—
—
—
0
0
36
212
1.74
2.44
4.6
13.9
25.5
24.4
mmol/l
0.90
31
201
56
371
1.56
2.42
1.6
1.4
—
—
—
0
0
509
4736
1.33
2.41
20.3
14.4
13.5
13.5
%
0.23
501
4648
42
262
1.64
2.33
1.5
1.7
5.0
8.0
u/l
2.53
29
214
196
1625
1.29
2.32
2.5
2.1
—
—
—
0
0
107
812
1.38
2.32
3.4
3.1
46.3
689.3
ng/l
2.42
72
544
143
1140
1.32
2.25
3.5
3.2
—
—
—
0
0
57
386
1.52
2.25
3.9
5.1
0.6
0.9
%
0.63
18
115
38
236
1.65
2.16
2.7
6.5
—
—
—
0
0
34
205
1.69
2.15
2.3
2.2
—
—
—
0
0
114
885
1.35
2.14
1.8
1.6
—
—
—
0
0
13
55
2.39
2.13
2.1
4.7
—
—
—
0
0
33
198
1.70
2.13
1.4
1.5
—
8.5
u/ml
—
0
7
20
102
1.99
2.12
3.1
3.6
52.5
55.2
%
0.38
20
102
54
367
1.51
2.11
3.9
5.3
0.0
0.1
%
2.84
16
104
187
1569
1.27
1.98
2.6
2.3
—
—
—
0
0
52
356
1.50
1.97
3.5
4.8
0.9
0.5
%
0.34
11
81
9
33
2.75
1.93
1.0
1.2
—
—
—
0
0
19
99
1.95
1.92
2.3
3.3
4.1
3.9
e9/l
0.14
19
99
26
152
1.74
1.86
1.2
1.3
—
—
—
0
0
23
130
1.80
1.84
2.7
2.1
13.1
11.5
mg/l
0.45
23
122
5
12
4.19
1.82
1.2
1.1
87.3
79.5
ug/l
—
5
12
5
12
4.19
1.82
1.8
2.2
2.3
1.5
nmol/l
—
5
12
26
153
1.73
1.82
1.5
1.6
—
—
—
0
0
176
1480
1.26
1.82
4.0
2.9
—
—
—
0
0
41
272
1.54
1.81
1.0
1.1
—
—
—
0
0
11
47
2.36
1.78
2.0
3.0
—
—
—
0
0
12
55
2.20
1.68
1.5
3.1
4.0
3.4
nmol/l
0.25
12
55
51
361
1.45
1.67
3.5
3.1
—
—
—
0
0
6
19
3.18
1.66
1.2
1.4
137.0
147.8
nmol/l
—
6
19
77
589
1.35
1.62
1.3
1.2
—
—
—
0
0
6
20
3.02
1.58
1.2
1.6
—
—
—
0
0
12
58
2.09
1.50
1.3
1.4
—
—
nmol/l
—
0
0
33
219
1.53
1.49
1.3
1.3
—
—
—
0
0
9
37
2.45
1.48
2.0
1.1
—
—
—
0
0
28
179
1.59
1.48
1.3
1.2
—
—
—
0
0
61
457
1.37
1.48
4.2
3.3
—
—
—
0
0
43
303
1.45
1.46
1.4
1.6
21.8
19.5
iu/l
0.14
29
253
13
66
1.99
1.44
1.3
1.4
0.6
0.6
nmol/l
0.04
13
60
6
23
2.62
1.37
1.2
1.8
1.2
1.2
nmol/l
—
6
18
10
47
2.15
1.34
1.4
1.3
0.0
0.1
u/ml
—
5
16
9
42
2.16
1.34
1.3
1.5
4.4
6.4
ug/l
—
9
35
155
1331
1.22
1.31
3.9
4.3
2.3
2.1
ug/l
0.06
138
1205
5
18
2.79
1.28
2.6
1.8
—
—
—
0
0
5
18
2.79
1.28
6.2
1.9
—
—
—
0
0
9
44
2.06
1.27
2.0
1.9
—
—
—
0
0
6
25
2.41
1.24
2.7
2.3
532.3
521.4
min
—
6
15
8
36
2.24
1.24
1.0
1.1
—
—
—
0
0
264
2394
1.17
1.19
3.9
4.1
—
—
—
0
0
16
94
1.72
1.18
1.7
1.5
11.8
20.4
u/l
0.66
11
79
17
102
1.68
1.17
2.2
1.4
—
—
—
0
0
15
87
1.74
1.16
1.7
1.8
—
—
—
0
0
8
39
2.06
1.15
1.1
1.1
—
—
—
0
0
22
143
1.56
1.13
1.5
1.6
126.4
102.6
u/ml
—
8
23
52
399
1.33
1.12
4.0
11.3
94.4
96.2
%
0.79
52
384
48
364
1.34
1.12
1.8
2.4
4.3
4.1
e9/l
0.14
33
302
12
66
1.83
1.09
1.2
1.8
—
—
—
0
0
5
21
2.39
1.09
6.2
1.8
—
—
—
0
0
8
41
1.96
1.09
1.3
1.2
—
—
—
0
0
139
1203
1.20
1.08
2.4
2.3
—
—
—
0
0
10
52
1.94
1.06
1.8
1.2
—
—
—
0
0
58
727
0.78
1.04
1.2
1.3
—
—
—
0
0
74
899
0.80
1.02
1.5
1.5
—
—
—
0
0
28
197
1.44
1.01
1.4
1.1
—
—
—
0
0
70
568
1.26
1.01
1.5
1.5
—
—
—
0
0
9
48
1.89
1.00
1.6
2.6
—
—
—
0
0
5
23
2.18
0.98
1.8
2.1
1.8
4.1
ug/l
—
5
23
28
199
1.43
0.97
1.6
1.5
—
—
—
0
0
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
68
555
1.25
0.95
1.4
1.4
—
—
—
0
0
18
117
1.55
0.94
4.4
1.7
0.9
0.8
nmol/l
0.24
18
101
24
167
1.45
0.93
7.3
9.1
—
—
—
0
0
6
28
2.15
0.91
1.3
5.1
—
7.4
—
0
9
8
42
1.92
0.89
1.4
2.8
13.3
23.1
ug/l
—
8
42
180
1988
0.87
0.86
2.7
2.4
—
—
—
0
0
6
31
1.94
0.84
2.7
2.3
571.8
582.6
ml
—
6
16
0
26
0.00
0.78
0.0
1.0
—
—
—
0
0
36
280
1.30
0.76
2.5
2.6
88.5
162.0
ng/l
1.53
30
248
7
38
1.85
0.73
2.3
1.4
—
69.6
—
0
5
5
25
2.01
0.73
1.4
4.8
—
—
—
0
0
13
84
1.56
0.72
3.5
3.3
—
—
—
0
0
10
61
1.65
0.69
1.9
1.4
280.4
288.6
mosm/kgh2o
—
5
46
5
27
1.86
0.68
5.0
8.8
—
—
—
0
0
5
28
1.79
0.66
1.2
1.1
118.6
176.9
iu/ml
—
5
28
5
28
1.79
0.66
1.0
1.0
—
—
—
0
0
11
71
1.56
0.62
1.6
1.9
—
—
—
0
0
10
63
1.60
0.62
1.3
1.4
—
—
—
0
0
49
409
1.21
0.60
2.2
2.3
4944.6
3015.1
u/l
0.18
12
165
8
51
1.58
0.60
3.3
10.1
10.9
11.8
%
—
8
51
19
140
1.37
0.59
3.7
2.5
—
—
—
0
0
8
53
1.52
0.58
1.3
1.4
—
—
—
0
0
20
149
1.35
0.58
3.2
5.1
—
—
—
0
0
6
37
1.63
0.55
6.3
3.3
0.9
0.7
nmol/l
—
6
27
13
91
1.44
0.53
3.7
2.8
17.1
16.3
%
—
6
48
10
66
1.52
0.52
1.1
1.3
0.5
3.5
u/ml
—
5
31
90
1003
0.88
0.51
2.1
1.8
—
—
—
0
0
12
84
1.44
0.49
1.5
1.3
—
—
—
0
0
16
212
0.75
0.49
1.4
1.4
—
—
—
0
0
16
212
0.75
0.49
1.4
1.4
—
—
—
0
0
7
106
0.66
0.49
2.1
3.9
—
—
—
0
0
22
172
1.29
0.48
2.1
2.2
1.7
1.4
g/l
0.73
17
145
13
94
1.39
0.46
1.9
1.7
—
—
—
0
0
86
773
1.13
0.46
2.6
2.7
0.6
0.7
ug/l
0.71
55
467
11
77
1.44
0.45
1.4
1.1
—
—
—
0
0
17
218
0.77
0.43
1.5
1.5
—
—
—
0
0
5
31
1.62
0.43
2.4
3.1
2.6
2.4
mmol/l
—
5
23
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
122
1318
0.91
0.41
1.8
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
5.6
—
135.6
—
0
12
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
14
107
1.32
0.37
1.1
1.1
—
—
—
0
0
5
37
1.35
0.37
1.4
2.6
—
—
—
0
0
6
42
1.43
0.35
1.2
1.1
—
—
—
0
0
14
108
1.30
0.35
1.9
2.5
134.9
128.8
g/l
—
9
80
6
43
1.40
0.35
1.8
1.6
—
—
—
0
0
16
197
0.81
0.31
1.1
1.2
6.2
1.9
u/ml
—
7
96
7
99
0.70
0.31
1.6
1.2
—
—
—
0
0
26
222
1.18
0.30
4.1
14.9
—
—
—
0
0
27
232
1.17
0.29
14.0
10.1
9.0
9.2
kpa
0.29
27
221
14
172
0.81
0.27
1.1
1.1
1.0
1.4
u/ml
—
5
95
13
104
1.26
0.26
1.7
1.2
—
—
—
0
0
10
77
1.30
0.26
2.0
4.7
—
—
—
0
0
5
72
0.69
0.26
1.0
1.0
12.3
8.7
mu/l
—
5
67
9
72
1.25
0.25
1.1
1.0
—
—
—
0
0
28
319
0.87
0.25
1.6
1.5
—
—
—
0
0
19
161
1.19
0.24
2.4
7.7
1.8
1.5
%
0.50
19
146
10
78
1.29
0.24
1.6
1.6
—
—
—
0
0
12
146
0.82
0.22
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
2.8
1.6
0.7
1.0
g/l
—
5
41
169
1756
0.95
0.21
1.5
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.4
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
9.2
—
—
—
0
0
0
14
0.00
0.20
0.0
7.6
—
—
—
0
0
6
49
1.23
0.20
1.7
1.2
—
—
—
0
0
6
49
1.23
0.20
1.0
1.0
—
—
—
0
0
7
58
1.21
0.18
3.4
2.2
—
—
—
0
0
7
59
1.19
0.18
1.4
1.6
—
—
—
0
0
11
91
1.21
0.17
2.6
3.1
17.4
62.7
u/ml
0.46
11
83
35
322
1.09
0.16
2.8
2.4
2.5
6.6
ug/l
4.61
26
290
10
83
1.21
0.15
1.2
1.3
—
—
—
0
0
9
79
1.14
0.15
1.6
1.2
—
—
—
0
0
11
93
1.19
0.14
1.0
1.1
—
—
—
0
0
8
99
0.81
0.13
1.1
1.5
—
—
—
0
0
18
161
1.12
0.13
1.9
7.7
0.9
0.9
%
0.12
18
147
12
104
1.16
0.12
1.9
4.0
40.6
30.4
mg/l
—
6
80
12
104
1.16
0.12
1.8
4.0
56.3
108.7
mg/l
—
6
79
10
85
1.18
0.12
3.3
4.9
—
—
—
0
0
13
147
0.88
0.11
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.8
3.0
—
—
—
0
0
16
176
0.91
0.09
1.1
1.1
1.6
7.2
u/ml
—
9
120
10
87
1.15
0.09
2.5
11.7
106.3
105.4
mmol/l
—
10
76
10
87
1.15
0.09
2.5
11.7
11.4
11.4
mmol/l
—
10
76
21
195
1.08
0.08
2.3
4.2
25.6
25.1
mmol/l
0.50
21
187
10
91
1.10
0.04
2.4
2.5
—
—
—
0
0
11
103
1.07
0.02
1.2
1.2
—
—
—
0
0
10
106
0.94
0.01
1.0
1.1
—
—
—
0
0
12
118
1.02
0.00
1.1
1.1
1.4
5.6
u/ml
—
5
61
28
277
1.01
0.00
1.3
1.4
166.3
262.7
miu/ml
—
9
140
20
199
1.01
0.00
2.7
3.0
—
—
—
0
0
35
351
1.00
0.00
2.7
4.5
3.5
19.3
ug/l
0.71
30
287
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
12.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
6091.7
—
0
9
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
15.0
—
110.2
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
6
67
0.89
0.00
1.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
34.6
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint F5_SLEEPWAKE and mortality.

Females

Parameter HR [95% CI] p-value
F5_SLEEPWAKE 2.192 [1.67, 2.88] < 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 2225 females with F5_SLEEPWAKE died.

Males

Parameter HR [95% CI] p-value
F5_SLEEPWAKE 2.046 [1.64, 2.55] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 2839 males with F5_SLEEPWAKE died.

Mortality risk

Mortality risk for people of age

years, who have F5_SLEEPWAKE.

N-year risk Females Males
1 0.236% 0.3%
5 1.1% 2.454%
10 2.53% 6.216%
15 4.99% 11.799%
20 8.937% 19.409%

Relationships between endpoints

Index endpoint: F5_SLEEPWAKE – Disorder of the sleep-wake schedule

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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