generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
509860 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
929 |
6. Filter based on genotype QC (FinnGen only) |
880 |
Control definitions (FinnGen only)
- Control exclude
- G6_EPLEPSY
- Control conditions
- not FE
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Generalized epilepsy, strict definition
based on the number of shared cases.
Similar with more cases:
- Generalized epilepsy
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13436 | 6594 | 6672 |
| Only index persons | 9660 | 5220 | 4440 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | 0.19 |
| Only index persons | 0.18 | 0.19 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 26.02 | 23.13 | 28.07 |
| Only index persons | 19.95 | 20.03 | 19.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 880 | 541 | 339 |
| Unadjusted period prevalence (%) | 0.18 | 0.19 | 0.16 |
| Median age at first event (years) | 25.10 | 23.15 | 28.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 929
- Matched controls
- 9290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G40.39
ICD-10 Finland
Other or unspecified generalized epileptic syndromes with atonic, clonic, myoclonic or tonic-clonic seizures
+∞
307.7
423
*
N03AG01
ATC
valproic acid; systemic, rectal
49.0
307.7
483
201
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
307.7
735
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3160.9
307.7
368
*
N03AX14
ATC
levetiracetam; systemic
119.7
307.7
183
19
R56.8
ICD-10 Finland
Other and unspecified convulsions
34.3
307.7
298
126
N03AF01
ATC
carbamazepine; oral, rectal
21.5
255.3
204
120
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
+∞
192.6
178
*
183
Kela drug reimbursment
Lamotrigin and topiramate
+∞
181.3
168
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2053.5
174.7
164
*
G40.3
ICD-10 Finland
Generalized idiopathic epilepsy and epileptic syndromes
+∞
170.2
158
*
N03AX09
ATC
lamotrigine; oral
10.3
158.4
198
238
G40.30
ICD-10 Finland
Benign myoclonic eplilepsy in infancy
+∞
156.8
146
*
N03AF02
ATC
oxcarbazepine; oral
24.8
141.1
102
46
G40.36
ICD-10 Finland
Juvenile myoclonic epilepsy [impulsive petit mal]
+∞
132.5
124
*
G40
ICD-10 Finland
Epilepsy
1374.7
126.1
120
*
N05BA01
ATC
diazepam; systemic, rectal
5.6
102.2
235
531
N88
ICPC
Epilepsy
+∞
82.5
78
*
7803A
ICD-9 Finland
General symptoms, Convulsions
17.4
81.2
68
42
34519
ICD-8 Finland
Epilepsy, Generalisata convulsiva NUD
+∞
78.2
74
*
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
+∞
78.2
74
*
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
+∞
75.0
71
*
N03AE01
ATC
clonazepam; systemic
6.5
59.6
103
174
3450A
ICD-9 Finland
Epilepsy, Generalised nonconvulsive epilepsy
+∞
52.6
50
*
G40.35
ICD-10 Finland
Juvenile absence epilepsy
+∞
52.6
50
*
G40.33
ICD-10 Finland
Juvenile absence epilepsy
+∞
51.5
49
*
N05CD08
ATC
midazolam; nasal, systemic
12.2
51.1
52
45
3459X
ICD-9 Finland
Epilepsy, unspecified
+∞
49.4
47
*
N03AD01
ATC
ethosuximide; oral
+∞
49.4
47
*
34599
ICD-8 Finland
Epilepsy, Other and unspecified
+∞
47.3
45
*
N05BA09
ATC
clobazam; oral
161.1
44.2
46
*
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
7.2
41.2
63
93
N03AB02
ATC
phenytoin; systemic
54.9
39.9
47
9
G40.89
ICD-10 Finland
Other epilepsy
+∞
39.9
38
*
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
13.8
38.4
36
27
34510
ICD-8 Finland
Epilepsy, """"Grand mal""""
+∞
35.6
34
*
3453A
ICD-9 Finland
Epilepsy, Grand mal status
+∞
28.3
27
*
N03AX11
ATC
topiramate; oral
5.0
22.9
50
104
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
20.5
101
370
XA800
NOMESCO Finland
Neuropsychological investigation
3.5
19.1
67
200
AA1AD
NOMESCO Finland
CT of head and brain
2.2
18.9
198
1032
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.9
18.9
92
335
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
18.5
74
240
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.9
18.2
91
336
N05AD01
ATC
haloperidol; systemic
5.0
17.7
38
78
R55
ICD-10 Finland
Syncope and collapse
2.7
17.5
100
396
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
16.7
99
400
N05AX08
ATC
risperidone; systemic
2.7
16.6
93
365
N03AX22
ATC
perampanel; oral
+∞
14.6
14
*
N03AX23
ATC
brivaracetam; systemic
+∞
14.6
14
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
36.7
14.5
18
5
N05AA02
ATC
levomepromazine; systemic
3.5
14.0
49
146
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.2
13.2
27
53
N03AX18
ATC
lacosamide; systemic
131.7
12.5
13
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.0
12.2
26
53
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
11.9
193
1157
34500
ICD-8 Finland
Epilepsy, """"Petit mal""""
+∞
11.5
11
*
G40.7
ICD-10 Finland
Petit mal, unspecified, without grand mal seizures
+∞
11.5
11
*
G40.37
ICD-10 Finland
Baltic myoclonus
+∞
11.5
11
*
R25.2
ICD-10 Finland
Cramp and spasm
4.2
11.2
30
74
3452A
ICD-9 Finland
Epilepsy, Petit mal status
+∞
10.4
10
*
G40.31
ICD-10 Finland
Benign neonatal convulsions (familial)
+∞
10.4
10
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.0
10.4
46
159
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.7
10.2
54
206
N05AH02
ATC
clozapine; systemic
3.7
9.4
30
84
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
30.4
9.4
12
*
G40.34
ICD-10 Finland
Epilepsy with grand mal seizures on awakening
+∞
9.4
9
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
9.4
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
9.4
95
483
Z2445
NOMESCO Finland
Psychologist
2.4
9.4
63
270
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
9.4
141
822
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
9.3
174
1081
N05AH04
ATC
quetiapine; oral
1.7
9.2
181
1140
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
9.1
123
692
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
8.9
176
1111
XA400
NOMESCO Finland
EEG
10.8
8.8
16
15
R56.0
ICD-10 Finland
Febrile convulsions
7.3
8.8
20
28
N06AB04
ATC
citalopram; systemic
1.7
8.8
163
1011
N05AH03
ATC
olanzapine; systemic
2.2
8.6
72
339
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.1
8.3
76
371
34598
ICD-8 Finland
Epilepsy, Alia definita
+∞
8.3
8
*
N05CD07
ATC
temazepam; oral
2.2
8.1
72
348
Y0209
ICD-8 Finland
Examination of the nervous system and sensory organs, Nervous system
11.8
8.1
14
12
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
8.0
78
391
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
7.9
121
709
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.0
7.8
18
26
A04
ICPC
Weakness/tiredness general
1.8
7.8
136
827
N03AA02
ATC
phenobarbital; systemic
45.4
7.7
9
*
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.6
7.7
18
40
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
7.6
61
283
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.4
7.5
50
214
G40.59
ICD-10 Finland
Other special epileptic syndromes
+∞
7.3
7
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.0
7.3
76
391
N03AX15
ATC
zonisamide; oral
30.3
7.2
9
*
N04AA02
ATC
biperiden; systemic
3.5
7.2
24
70
R42
ICD-10 Finland
Dizziness and giddiness
1.7
7.1
151
968
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.2
7.1
58
272
R11
ICD-10 Finland
Nausea and vomiting
1.9
7.0
86
468
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.4
6.9
24
72
R40.2
ICD-10 Finland
Coma, unspecified
11.0
6.8
12
11
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
6.2
6.8
17
28
N05AF03
ATC
chlorprothixene; systemic
3.1
6.8
27
88
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
40.4
6.8
8
*
R60.9
ICD-10 Finland
Oedema, unspecified
2.6
6.8
39
156
A10AB01
ATC
insulin (human); parenteral
2.5
6.7
39
157
7802X
ICD-9 Finland
General symptoms, Syncope and collapse[SYNCOPE ET COLLAPSUS NUD]
12.4
6.6
11
9
C03CA01
ATC
furosemide; systemic
1.6
6.6
149
971
N05AB03
ATC
perphenazine; systemic, rectal
2.8
6.5
32
118
G41.0
ICD-10 Finland
Grand mal status epilepticus
70.3
6.4
7
*
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.4
202
1421
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
11.1
6.3
11
10
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.1
6.2
25
82
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.3
6.2
44
194
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.2
187
1302
C07AA05
ATC
propranolol; systemic
1.6
6.2
180
1244
Z3231
NOMESCO Finland
Registered nurse
1.5
6.1
222
1609
E9509
ICD-8 Finland
Suicide and self-inflicted poisoning by solid or liquid substances, Other and unspecified solid and liquid substances
10.1
6.0
11
11
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.1
6.0
58
290
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
214
82
33.61
319.95
4.2
6.2
389.30
378.21
umol/l
0.25
198
72
51
17
31.68
77.77
3.3
1.7
16.61
13.75
umol/l
0.78
51
17
297
1650
2.18
24.93
2.5
2.0
197.67
227.46
u/l
0.28
290
1564
515
3872
1.74
15.05
5.1
5.0
6.44
6.47
mmol/l
0.09
473
3534
425
3035
1.74
14.89
6.2
7.4
1.21
1.22
mmol/l
2.17
369
2645
381
2747
1.66
12.15
5.6
7.2
1.21
1.22
mmol/l
2.30
356
2532
328
2400
1.57
9.20
3.5
3.4
31.50
31.34
u/l
0.03
310
2289
113
625
1.92
8.80
2.7
2.4
27.40
37.97
u/l
1.87
101
522
459
3702
1.47
7.72
6.2
6.4
31.78
30.40
%
1.74
430
3524
449
3664
1.44
6.78
5.8
6.2
53.93
55.20
%
1.34
421
3485
788
7203
1.62
6.44
14.8
12.2
139.20
139.58
mmol/l
3.49
765
7011
587
5068
1.43
6.27
6.6
6.7
77.51
81.15
u/l
1.28
545
4773
406
3286
1.42
6.25
5.7
6.0
10.05
12.48
umol/l
1.91
375
3109
278
2104
1.46
6.15
3.0
3.1
18.88
28.45
ng/l
1.62
138
1166
296
2276
1.44
6.00
1.9
1.8
98.31
96.59
pmol/l
0.24
158
1207
263
1992
1.45
5.74
2.6
2.5
53.32
59.62
u/l
0.96
244
1853
786
7227
1.57
5.74
14.7
12.2
3.96
3.94
mmol/l
0.83
759
7016
323
2542
1.41
5.70
4.5
5.2
36.21
36.72
g/l
0.88
301
2382
158
1081
1.56
5.65
1.9
1.7
1.41
1.42
%
0.01
147
988
498
4239
1.38
5.40
9.8
8.8
3.96
3.95
e9/l
0.04
423
3686
104
663
1.64
4.99
4.2
6.4
0.76
1.51
mmol/l
1.14
88
530
154
1079
1.51
4.91
3.4
3.2
509.01
702.89
ng/l
0.19
100
700
103
666
1.61
4.67
4.2
6.3
5.67
5.80
kpa
0.64
95
649
57
312
1.88
4.64
1.4
1.5
—
—
—
0
0
260
2031
1.39
4.63
2.5
3.0
2.35
2.36
mmol/l
0.60
231
1829
572
5085
1.32
4.13
3.8
3.0
48.10
40.17
u/l
1.86
550
4852
239
1881
1.36
3.99
3.3
3.4
7.37
8.13
mmol/l
1.45
200
1659
305
2491
1.33
3.99
10.2
10.0
1.09
1.16
inr
1.16
94
778
13
32
4.11
3.91
1.8
5.2
231.50
204.12
umol/l
—
6
17
823
7781
1.51
3.85
10.4
8.7
26.81
26.67
u/l
0.06
792
7546
344
2873
1.31
3.81
2.4
2.5
72.13
73.16
nmol/l
0.26
312
2662
91
602
1.57
3.78
2.3
2.9
0.24
0.22
g/l
1.46
86
571
14
46
3.07
3.54
1.4
1.2
1.75
1.76
mmol/l
0.01
14
46
83
549
1.56
3.46
4.3
7.2
0.75
1.31
mmol/l
0.97
62
402
52
306
1.74
3.41
1.3
1.3
—
—
—
0
0
46
261
1.80
3.41
1.1
1.1
1.27
6.03
u/ml
—
8
47
85
568
1.55
3.39
4.3
7.1
5.15
5.04
kpa
0.80
79
547
86
589
1.51
3.08
3.7
6.2
4.93
4.85
kpa
0.13
78
573
128
949
1.40
3.04
1.7
1.8
—
—
—
0
0
165
1276
1.36
3.03
1.5
1.5
22.13
20.89
nmol/l
0.42
148
1124
194
1569
1.30
2.61
1.7
2.1
1.76
1.17
mg/l
0.39
140
1162
26
136
1.94
2.52
1.1
1.2
79.20
145.57
iu/ml
—
5
47
194
1576
1.29
2.52
3.3
3.3
1.02
1.02
kg/l
0.33
31
223
79
557
1.46
2.49
8.2
9.7
1.29
0.80
mmol/l
0.40
68
448
82
585
1.44
2.44
1.9
2.3
7838.76
5704.93
u/l
0.18
35
256
63
427
1.51
2.42
1.8
1.7
—
—
—
0
0
7
18
3.91
2.25
5.3
3.5
—
—
—
0
0
7
18
3.91
2.25
5.3
3.5
—
—
—
0
0
32
188
1.73
2.19
1.3
1.3
300.72
315.84
ug/g
0.15
18
105
40
250
1.63
2.19
1.1
1.2
4.81
7.16
u/ml
0.39
17
157
247
2103
1.24
2.14
1.4
1.4
1.92
1.75
u/ml
0.07
50
549
116
901
1.33
2.09
1.8
1.6
1041.43
1170.61
nmol/l
0.93
87
692
9
31
2.92
2.07
1.2
1.2
—
—
—
0
0
9
31
2.92
2.07
1.2
1.2
—
—
—
0
0
780
7480
1.27
1.91
14.1
11.2
20.80
21.37
mg/l
0.17
625
5733
23
129
1.80
1.87
1.1
1.2
2.11
5.00
u/ml
—
9
43
504
4641
1.19
1.86
4.1
3.9
656.83
764.38
e6/l
0.08
12
68
5
12
4.18
1.82
1.2
1.3
—
—
—
0
0
71
524
1.38
1.80
7.0
9.6
1.51
1.40
mmol/l
0.41
71
508
7
23
3.06
1.80
1.4
2.2
199.29
210.48
u/l
—
7
23
85
646
1.35
1.80
1.7
1.7
—
—
—
0
0
182
1529
1.24
1.78
4.3
3.9
16.43
21.88
mg/mmol
0.18
125
1003
9
36
2.51
1.74
1.7
1.7
—
—
—
0
0
9
36
2.51
1.74
1.7
1.7
—
—
—
0
0
37
243
1.54
1.70
1.1
1.2
0.28
1.58
u/ml
1.52
15
131
62
452
1.40
1.70
1.5
1.5
274.71
291.70
mu/l
0.28
55
405
13
63
2.08
1.60
1.2
1.5
4.32
6.69
u/ml
—
8
37
10
43
2.34
1.59
1.1
1.0
—
—
—
0
0
10
44
2.29
1.56
2.7
2.7
34530.00
41109.09
ug/l
—
10
44
22
130
1.71
1.54
1.1
1.2
2.25
5.82
u/ml
—
8
57
84
654
1.31
1.54
1.6
1.8
—
—
—
0
0
15
79
1.91
1.50
1.5
1.4
—
—
—
0
0
682
6501
1.18
1.50
10.8
9.5
95.79
90.92
ml/min/173m2
6.33
533
5171
67
507
1.35
1.49
2.3
2.3
22.38
17.91
au/ml
—
5
37
25
389
0.63
1.47
1.2
1.8
3.37
3.63
mg/l
0.12
14
266
72
557
1.32
1.39
1.0
1.1
—
—
—
0
0
550
5171
1.16
1.38
3.6
3.8
10.18
9.74
mm/h
0.32
505
4826
6
23
2.62
1.37
1.2
1.2
—
—
—
0
0
21
128
1.66
1.34
1.1
1.1
—
—
—
0
0
39
275
1.44
1.33
1.2
1.2
2.07
3.11
u/ml
0.34
17
162
39
275
1.44
1.33
8.7
12.2
23.93
24.11
mmol/l
0.09
39
269
656
6843
0.86
1.31
4.0
3.7
4.71
4.71
mmol/l
0.05
618
6496
14
76
1.85
1.30
1.4
1.4
—
—
—
0
0
64
821
0.76
1.29
2.0
2.5
0.80
0.72
ug/l
0.21
36
454
702
6738
1.17
1.28
5.0
4.5
1.86
2.00
mu/l
0.35
651
6317
22
138
1.61
1.27
1.5
1.3
—
—
—
0
0
14
77
1.83
1.26
1.4
1.4
—
—
—
0
0
14
77
1.83
1.26
1.4
1.4
—
—
—
0
0
14
77
1.83
1.26
1.4
1.4
—
—
—
0
0
602
5718
1.15
1.25
4.2
3.9
14.25
14.50
pmol/l
1.78
552
5302
27
179
1.52
1.24
1.0
1.1
8.72
8.31
u/ml
0.02
12
86
653
6804
0.86
1.23
3.9
3.6
1.43
1.46
mmol/l
0.97
612
6431
153
1314
1.20
1.22
2.6
3.3
784.01
985.34
ng/l
0.47
116
1096
22
140
1.59
1.21
6.3
3.8
17.91
30.24
mg/l
1.74
15
96
664
6906
0.86
1.20
4.3
4.0
2.84
2.84
mmol/l
0.07
623
6506
26
173
1.52
1.19
1.0
1.1
0.18
0.34
u/ml
—
6
70
6
26
2.32
1.19
2.0
1.8
—
—
—
0
0
6
26
2.32
1.19
2.0
1.8
—
—
—
0
0
10
50
2.01
1.16
1.7
1.6
—
—
—
0
0
108
901
1.22
1.16
5.6
7.1
1.13
1.13
mmol/l
0.02
103
846
34
241
1.43
1.15
1.2
1.2
1.15
2.58
u/ml
0.84
15
145
16
95
1.70
1.14
1.8
2.2
—
—
—
0
0
16
95
1.70
1.14
1.3
1.3
—
—
—
0
0
5
114
0.44
1.12
1.2
1.8
—
—
—
0
0
5
114
0.44
1.12
1.2
1.8
—
—
—
0
0
8
40
2.01
1.12
1.0
1.1
—
—
—
0
0
8
40
2.01
1.12
1.6
2.8
—
—
—
0
0
34
243
1.41
1.11
1.9
1.8
—
—
—
0
0
28
193
1.46
1.10
1.0
1.1
1.37
7.54
u/ml
3.51
16
111
65
515
1.28
1.10
1.2
1.4
—
—
—
0
0
5
21
2.39
1.09
1.0
1.5
13.36
7.71
ug/l
—
5
21
178
1566
1.17
1.08
2.3
2.7
7177.03
5750.63
umol/l
0.11
154
1408
210
1873
1.16
1.07
1.4
1.5
2.34
2.14
g/l
0.66
111
1162
7
33
2.13
1.05
1.1
1.2
—
—
—
0
0
121
1034
1.20
1.04
2.1
2.9
6.75
2.78
e6/l
0.94
55
555
11
60
1.84
1.03
1.0
1.2
—
—
—
0
0
192
1708
1.16
1.01
2.0
2.2
2.64
2.85
mg/l
0.65
158
1474
5
108
0.46
1.01
1.2
1.5
—
—
—
0
0
12
68
1.77
1.01
1.9
2.0
—
—
—
0
0
11
61
1.81
0.98
1.0
1.2
—
—
—
0
0
63
506
1.26
0.97
1.5
1.5
22.49
22.52
iu/l
0.00
55
417
24
165
1.47
0.97
1.3
2.1
3.72
3.62
mmol/l
0.18
24
155
6
27
2.23
0.93
2.0
1.8
—
—
—
0
0
12
70
1.72
0.93
1.0
1.1
181.50
237.29
mg/l
0.74
12
60
94
1102
0.84
0.89
2.9
3.5
21.73
21.81
%
0.01
31
430
30
220
1.38
0.88
1.6
1.6
—
—
—
0
0
13
79
1.65
0.88
1.5
1.4
—
—
—
0
0
32
423
0.75
0.86
1.5
1.6
—
—
—
0
0
26
188
1.39
0.83
1.7
1.2
17.30
8.83
u/ml
—
7
29
123
1076
1.16
0.83
2.0
2.7
1.13
0.84
e6/l
0.47
56
593
11
65
1.70
0.82
1.0
1.0
—
—
—
0
0
217
1979
1.13
0.80
2.5
3.2
44.27
86.08
e6/l
0.53
167
1495
106
919
1.17
0.80
2.1
2.4
2.46
2.43
g/l
0.25
98
848
11
66
1.67
0.79
1.1
1.1
—
—
—
0
0
132
1488
0.87
0.79
1.4
1.5
—
—
—
0
0
5
96
0.52
0.78
1.2
1.7
—
—
—
0
0
10
162
0.61
0.77
4.0
2.6
—
—
—
0
0
698
6780
1.12
0.77
18.2
13.7
13.90
14.21
%
1.09
686
6685
634
6546
0.90
0.77
3.5
3.3
1.34
1.26
mmol/l
1.78
595
6168
78
662
1.19
0.76
1.2
1.2
145.92
157.05
iu/ml
0.08
20
271
93
806
1.17
0.72
3.2
3.4
5.86
7.59
umol/l
0.67
73
680
7
40
1.76
0.71
1.4
1.6
—
—
—
0
0
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
9
59
1.53
0.68
1.7
1.6
—
—
—
0
0
9
59
1.53
0.68
1.7
1.6
—
—
—
0
0
9
59
1.53
0.68
1.7
1.6
—
—
—
0
0
7
43
1.63
0.67
2.9
2.4
—
—
—
0
0
172
1882
0.89
0.65
3.3
3.4
0.00
0.01
estimate
1.08
57
670
11
70
1.58
0.65
4.4
2.5
106.00
105.73
mmol/l
0.11
11
70
11
70
1.58
0.65
4.4
2.5
4.09
4.04
mmol/l
0.18
11
70
34
269
1.27
0.64
1.4
1.3
—
—
—
0
0
77
667
1.17
0.62
4.1
3.5
31.85
31.75
%
0.02
55
490
95
837
1.15
0.61
2.1
2.5
25.40
23.31
%
0.60
77
742
5
30
1.67
0.61
1.0
1.3
—
—
—
0
0
13
187
0.69
0.61
1.8
1.7
—
—
—
0
0
43
353
1.23
0.61
1.6
1.6
7.80
8.49
u/l
0.13
33
280
29
367
0.78
0.61
1.9
1.7
—
—
—
0
0
51
427
1.21
0.60
1.6
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
53
446
1.20
0.59
3.1
4.8
86.86
72.00
ng/l
0.42
44
410
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
24
184
1.31
0.58
3.5
2.0
0.74
2.55
ug/l
0.62
19
164
15
106
1.42
0.58
2.5
2.5
15.97
16.71
%
—
6
61
5
87
0.57
0.56
1.2
1.6
—
—
—
0
0
33
266
1.25
0.56
4.7
5.2
0.61
0.66
%
0.43
33
266
47
394
1.20
0.56
2.0
2.2
12.21
7.92
ug/l
0.20
36
354
126
1388
0.89
0.55
2.9
3.8
1.61
1.99
ug/l
0.65
113
1269
6
38
1.58
0.54
1.0
1.0
—
—
—
0
0
21
161
1.31
0.52
1.1
1.1
3.47
1.73
u/ml
—
9
73
18
135
1.34
0.51
2.4
2.0
—
—
—
0
0
79
699
1.14
0.50
1.7
2.1
407.00
369.67
nmol/l
0.75
72
659
33
270
1.23
0.50
1.2
1.1
—
—
—
0
0
243
2286
1.09
0.50
2.5
3.3
—
—
—
0
0
128
1168
1.11
0.50
1.6
1.6
420.22
25342889.38
pmol/l
1.32
107
1022
10
67
1.50
0.50
1.2
1.2
5.49
5.64
umol/l
—
10
60
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
45
1.56
0.49
1.0
1.1
—
—
—
0
0
11
76
1.45
0.48
1.4
1.5
24.71
38.37
nmol/l
0.65
11
68
28
227
1.24
0.47
1.1
1.2
—
—
—
0
0
123
1126
1.11
0.46
2.0
2.7
80.70
103.04
ug/g
0.84
87
905
5
82
0.61
0.46
1.0
1.0
—
—
—
0
0
15
198
0.75
0.45
1.7
2.0
—
—
—
0
0
5
85
0.59
0.45
1.0
1.4
—
—
—
0
0
132
1215
1.10
0.45
1.2
1.3
25.10
26.96
iu/ml
0.07
45
382
9
129
0.69
0.43
1.8
1.7
—
—
—
0
0
27
221
1.23
0.42
1.2
1.3
—
—
—
0
0
845
8533
0.89
0.42
21.7
16.4
251.98
258.25
e9/l
2.17
819
8329
0
15
0.00
0.41
0.0
2.7
—
34.00
—
0
15
27
325
0.83
0.40
1.4
1.5
—
—
—
0
0
64
570
1.13
0.39
2.6
2.7
—
—
—
0
0
847
8548
0.90
0.39
21.8
16.5
135.46
136.10
g/l
0.69
839
8448
15
115
1.31
0.39
1.6
1.5
—
—
—
0
0
27
224
1.21
0.38
1.1
1.2
—
—
—
0
0
11
80
1.38
0.38
1.1
1.4
—
—
—
0
0
108
994
1.10
0.38
2.1
2.4
14.64
13.96
umol/l
0.40
100
931
8
113
0.71
0.37
1.0
1.1
—
—
—
0
0
19
152
1.26
0.37
1.4
2.2
10.86
10.40
g/l
0.21
19
142
53
470
1.14
0.36
2.2
3.5
4.55
4.76
pmol/l
0.74
46
419
177
1670
1.07
0.35
2.3
2.2
—
—
—
0
0
5
80
0.62
0.35
2.4
1.8
—
—
—
0
0
9
122
0.74
0.35
1.1
1.6
—
—
—
0
0
17
135
1.26
0.35
2.5
2.6
123.50
131.90
g/l
0.94
12
106
847
8542
0.90
0.35
21.6
16.3
4.52
4.56
e12/l
1.51
822
8320
79
865
0.91
0.34
2.0
1.9
—
—
—
0
0
105
971
1.09
0.34
2.4
2.6
2.42
2.43
mmol/l
0.36
90
845
36
312
1.16
0.33
1.8
1.7
—
—
—
0
0
16
127
1.26
0.33
2.1
2.4
30.82
106.70
ug/min
—
8
77
184
1744
1.07
0.33
2.3
2.2
—
—
—
0
0
142
1337
1.07
0.31
2.2
2.6
8.11
6.64
e6/l
0.39
126
1192
19
156
1.22
0.31
1.4
1.3
—
—
—
0
0
19
156
1.22
0.31
1.3
1.1
—
—
—
0
0
15
186
0.80
0.31
1.3
1.5
—
—
—
0
0
7
100
0.70
0.30
2.0
1.6
—
—
—
0
0
61
553
1.11
0.30
2.3
2.1
9.87
12.63
nmol/l
2.01
52
506
16
129
1.24
0.30
3.6
5.4
—
2352.67
—
0
12
20
166
1.21
0.30
1.4
2.1
6.61
7.26
g/l
1.33
20
157
20
166
1.21
0.30
1.4
2.1
—
—
—
0
0
20
166
1.21
0.30
1.4
2.1
3.56
3.58
g/l
0.03
20
157
19
157
1.21
0.29
1.4
2.2
2.62
2.90
g/l
0.51
19
148
26
222
1.18
0.29
1.4
1.9
—
—
—
0
0
847
8533
0.92
0.29
21.8
16.5
39.59
40.41
%
2.88
806
8119
322
3325
0.95
0.29
3.0
2.6
—
—
—
0
0
175
1666
1.06
0.28
1.8
1.7
1.51
1.40
mmol/l
0.54
147
1449
14
112
1.25
0.28
1.0
2.1
—
653.33
—
0
6
365
3548
1.05
0.27
3.3
3.2
0.00
0.00
estimate
0.80
64
711
16
131
1.23
0.27
7.6
4.1
53.62
55.44
%
0.20
16
131
9
121
0.74
0.27
1.3
1.2
—
—
—
0
0
8
65
1.23
0.27
1.0
1.1
—
—
—
0
0
28
321
0.87
0.27
1.4
1.4
—
—
—
0
0
37
415
0.89
0.26
2.2
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
132
1.22
0.26
3.8
4.7
0.27
0.33
u/ml
—
7
73
40
359
1.12
0.25
1.3
1.4
—
—
—
0
0
62
571
1.09
0.24
1.3
1.3
130.63
244.29
u/ml
1.27
56
532
365
3557
1.04
0.24
4.9
4.5
0.00
0.00
estimate
0.50
60
687
187
1794
1.05
0.24
2.5
3.1
0.29
0.31
e6/l
0.12
140
1331
227
2189
1.05
0.24
1.9
1.7
—
—
—
0
0
26
296
0.87
0.23
1.4
1.5
—
—
—
0
0
12
97
1.24
0.23
1.2
1.3
—
—
—
0
0
123
1168
1.06
0.23
1.3
1.3
3.60
10.41
u/ml
1.59
39
472
368
3592
1.04
0.22
3.4
3.3
0.00
0.00
estimate
0.50
58
660
164
1571
1.05
0.22
2.2
2.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
0.45
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
2.64
—
0
5
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
7.8
—
—
—
0
0
17
198
0.86
0.20
1.4
1.5
—
—
—
0
0
85
900
0.94
0.20
1.5
1.6
—
—
—
0
0
12
99
1.21
0.19
1.7
1.5
—
—
—
0
0
10
81
1.24
0.19
1.1
1.7
—
—
—
0
0
15
128
1.17
0.18
8.1
3.9
3.95
4.12
e9/l
0.11
15
128
24
214
1.12
0.17
2.2
2.8
6.52
6.72
umol/l
0.03
19
163
7
61
1.15
0.17
1.1
1.2
—
—
—
0
0
10
82
1.22
0.17
1.6
2.0
—
—
—
0
0
23
205
1.13
0.17
1.1
1.2
—
—
—
0
0
356
3627
0.97
0.16
3.0
2.9
116.51
87.11
ug/l
0.71
333
3419
69
653
1.06
0.15
4.2
5.8
—
—
—
0
0
6
80
0.75
0.15
1.2
1.6
—
—
—
0
0
81
850
0.95
0.15
1.3
1.5
—
—
—
0
0
48
449
1.07
0.15
4.5
4.2
3.54
41.09
ug/l
1.31
41
369
9
82
1.10
0.15
1.0
1.1
—
—
—
0
0
11
93
1.18
0.14
1.0
1.3
—
—
—
0
0
51
480
1.07
0.14
1.9
2.6
75.00
73.03
ml/min/173m2
0.12
18
180
8
99
0.81
0.13
1.1
1.5
—
—
—
0
0
17
151
1.13
0.13
1.4
2.3
2.14
0.58
g/l
0.54
17
138
46
433
1.07
0.12
3.7
3.3
1.22
1.23
mmol/l
0.14
41
371
16
142
1.13
0.12
1.3
1.3
—
—
—
0
0
16
142
1.13
0.12
1.3
1.3
—
—
—
0
0
10
85
1.18
0.12
1.0
1.1
—
—
—
0
0
10
86
1.16
0.11
1.0
1.1
—
—
—
0
0
621
6255
0.98
0.10
3.7
3.6
—
—
—
0
0
47
447
1.05
0.10
1.3
1.4
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
47
448
1.05
0.09
1.3
1.4
—
—
—
0
0
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
47
449
1.05
0.09
1.3
1.4
—
—
—
0
0
47
450
1.05
0.08
1.3
1.4
—
—
—
0
0
38
399
0.95
0.08
1.3
1.3
241.59
255.24
miu/ml
0.10
19
197
8
76
1.05
0.07
4.0
2.9
—
—
—
0
0
22
235
0.93
0.07
1.5
1.5
290.21
213.33
u/ml
0.43
14
127
26
245
1.06
0.07
1.5
1.6
0.08
0.27
iu/ml
—
10
43
57
552
1.03
0.06
1.5
1.4
—
—
—
0
0
24
254
0.94
0.06
1.4
1.5
1.05
1.18
g/l
1.08
19
240
50
485
1.03
0.05
1.2
1.5
—
—
—
0
0
17
159
1.07
0.05
1.2
1.1
—
—
—
0
0
11
120
0.92
0.05
1.6
1.7
8.74
7.67
mmol/l
0.73
11
114
273
2752
0.99
0.04
3.3
3.2
—
—
—
0
0
18
189
0.95
0.03
1.4
1.7
—
—
—
0
0
14
148
0.95
0.02
1.5
1.8
—
—
—
0
0
14
148
0.95
0.02
1.5
1.4
6.84
19.27
u/l
—
9
127
14
148
0.95
0.02
1.5
1.8
—
—
—
0
0
108
1069
1.01
0.02
2.3
2.0
—
—
—
0
0
603
6043
0.99
0.02
5.5
4.6
39.24
38.47
mmol/mol
0.92
559
5703
13
137
0.95
0.01
1.3
2.2
39.22
39.68
g/l
0.11
13
128
658
6591
0.99
0.01
4.0
3.6
5.84
5.74
mmol/l
0.96
614
6122
22
213
1.03
0.01
1.2
1.3
3.04
3.40
ug/l
0.20
22
196
14
134
1.05
0.00
1.1
1.4
—
—
—
0
0
24
246
0.97
0.00
1.6
1.5
0.17
0.24
g/l
2.89
19
234
13
128
1.02
0.00
1.3
2.2
0.00
0.00
g/l
-0.00
13
120
14
137
1.02
0.00
1.3
2.2
0.00
0.04
g/l
0.50
14
129
13
127
1.02
0.00
1.3
2.2
0.00
0.00
g/l
-0.00
13
120
24
243
0.99
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.2
—
—
—
0
0
15
150
1.00
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.3
1.62
1.31
nmol/l
—
6
57
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.8
—
20.40
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.0
—
4.56
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
53
0.94
-0.00
3.0
3.1
30.60
25.65
umol/l
—
5
53
0
5
0.00
-0.00
0.0
5.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint GE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 3.042 [2.55, 3.62] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.156 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 3730 females with GE_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 2.983 [2.53, 3.52] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 387 out of 3234 males with GE_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have GE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.259% | 0.522% |
| 5 | 1.7% | 3.308% |
| 10 | 4.063% | 8.705% |
| 15 | 8.056% | 15.884% |
| 20 | 14.044% | 25.461% |
Relationships between endpoints
↥Index endpoint: GE_STRICT – Generalized epilepsy, strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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