generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
510657 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
922 |
6. Filter based on genotype QC (FinnGen only) |
922 |
Control definitions (FinnGen only)
- Control exclude
- G6_EPLEPSY
- Control conditions
- not FE
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Generalized epilepsy, strict definition
based on the number of shared cases.
Similar with more cases:
- Generalized epilepsy
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13436 | 6594 | 6672 |
| Only index persons | 9660 | 5220 | 4440 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | 0.19 |
| Only index persons | 0.18 | 0.19 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 26.02 | 23.13 | 28.07 |
| Only index persons | 19.95 | 20.03 | 19.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 922 | 562 | 360 |
| Unadjusted period prevalence (%) | 0.18 | 0.19 | 0.16 |
| Median age at first event (years) | 24.69 | 23.06 | 27.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 842
- Matched controls
- 8419
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
323.0
660
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
1285.7
323.0
321
*
G40.39
ICD-10 Finland
Other or unspecified generalized epileptic syndromes with atonic, clonic, myoclonic or tonic-clonic seizures
+∞
323.0
382
*
N03AG01
ATC
valproic acid; systemic, rectal
52.3
323.0
428
163
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
+∞
179.8
166
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
24.7
176.3
258
148
G40.3
ICD-10 Finland
Generalized idiopathic epilepsy and epileptic syndromes
+∞
157.3
146
*
183
Kela drug reimbursment
Lamotrigin and topiramate
+∞
154.0
143
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
842.4
147.8
141
*
N03AX14
ATC
levetiracetam; systemic
124.4
144.7
153
15
G40.30
ICD-10 Finland
Benign myoclonic eplilepsy in infancy
+∞
140.6
131
*
N03AF01
ATC
carbamazepine; oral, rectal
26.4
135.5
192
93
G40.36
ICD-10 Finland
Juvenile myoclonic epilepsy [impulsive petit mal]
+∞
114.2
107
*
G40
ICD-10 Finland
Epilepsy
1029.4
95.9
92
*
N03AX09
ATC
lamotrigine; oral
11.6
85.9
169
179
N03AF02
ATC
oxcarbazepine; oral
37.6
73.6
94
28
34519
ICD-8 Finland
Epilepsy, Generalisata convulsiva NUD
+∞
70.8
67
*
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
+∞
67.6
64
*
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
+∞
64.4
61
*
N05BA01
ATC
diazepam; systemic, rectal
5.2
59.5
210
507
N88
ICPC
Epilepsy
596.7
57.3
56
*
3450A
ICD-9 Finland
Epilepsy, Generalised nonconvulsive epilepsy
+∞
51.6
49
*
3459X
ICD-9 Finland
Epilepsy, unspecified
+∞
46.3
44
*
G40.35
ICD-10 Finland
Juvenile absence epilepsy
+∞
46.3
44
*
34599
ICD-8 Finland
Epilepsy, Other and unspecified
+∞
45.2
43
*
7803A
ICD-9 Finland
General symptoms, Convulsions
19.9
41.6
63
34
G40.33
ICD-10 Finland
Juvenile absence epilepsy
+∞
41.0
39
*
N03AD01
ATC
ethosuximide; oral
+∞
37.8
36
*
N03AB02
ATC
phenytoin; systemic
47.4
37.2
45
10
34510
ICD-8 Finland
Epilepsy, """"Grand mal""""
+∞
34.6
33
*
G40.89
ICD-10 Finland
Other epilepsy
+∞
29.3
28
*
N03AE01
ATC
clonazepam; systemic
5.8
29.3
86
161
N05BA09
ATC
clobazam; oral
107.2
28.8
31
*
3453A
ICD-9 Finland
Epilepsy, Grand mal status
+∞
25.1
24
*
N05CD08
ATC
midazolam; nasal, systemic
13.2
25.1
44
35
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
7.8
21.2
49
66
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
15.1
19.5
32
22
N03AX11
ATC
topiramate; oral
6.2
16.1
43
72
N05AX08
ATC
risperidone; systemic
3.2
15.8
86
289
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.8
14.3
62
174
XA800
NOMESCO Finland
Neuropsychological investigation
3.9
14.2
58
155
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
14.1
85
305
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.0
14.1
86
312
G41.9
ICD-10 Finland
Status epilepticus, unspecified
76.4
13.6
15
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
13.2
84
313
N05AD01
ATC
haloperidol; systemic
5.1
12.8
40
82
N05AA02
ATC
levomepromazine; systemic
4.1
12.7
49
124
34500
ICD-8 Finland
Epilepsy, """"Petit mal""""
+∞
11.5
11
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
11.3
77
299
AA1AD
NOMESCO Finland
CT of head and brain
2.1
11.1
143
759
R55
ICD-10 Finland
Syncope and collapse
2.5
10.6
83
348
G40.31
ICD-10 Finland
Benign neonatal convulsions (familial)
+∞
10.4
10
*
G40.37
ICD-10 Finland
Baltic myoclonus
+∞
10.4
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
9.8
153
874
N05AH02
ATC
clozapine; systemic
5.3
9.6
28
54
G40.7
ICD-10 Finland
Petit mal, unspecified, without grand mal seizures
+∞
9.4
9
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
9.4
9
*
G40.34
ICD-10 Finland
Epilepsy with grand mal seizures on awakening
+∞
9.4
9
*
R56.0
ICD-10 Finland
Febrile convulsions
10.8
9.3
17
16
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.0
9.2
53
187
N05AH04
ATC
quetiapine; oral
1.9
9.1
153
899
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.2
9.0
46
149
N05AH03
ATC
olanzapine; systemic
2.6
9.0
65
264
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
8.9
105
537
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.1
8.7
47
159
N03AX18
ATC
lacosamide; systemic
50.5
8.7
10
*
R53
ICD-10 Finland
Malaise and fatigue
1.8
8.6
154
922
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
8.6
145
850
N03AA02
ATC
phenobarbital; systemic
90.9
8.4
9
*
N03AX22
ATC
perampanel; oral
90.9
8.4
9
*
34598
ICD-8 Finland
Epilepsy, Alia definita
+∞
8.3
8
*
3452A
ICD-9 Finland
Epilepsy, Petit mal status
+∞
8.3
8
*
XA400
NOMESCO Finland
EEG
10.9
8.3
15
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
8.2
79
370
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
8.2
157
961
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
8.0
116
644
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.4
7.9
69
306
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
6.9
7.3
17
25
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.5
7.3
24
54
N03AX23
ATC
brivaracetam; systemic
+∞
7.3
7
*
R40.2
ICD-10 Finland
Coma, unspecified
15.9
7.2
11
7
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.3
7.2
65
296
N04AA02
ATC
biperiden; systemic
4.6
7.1
23
51
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
8.9
7.1
14
16
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.1
6.9
25
62
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
13.9
6.9
11
8
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.2
6.8
24
58
Y0209
ICD-8 Finland
Examination of the nervous system and sensory organs, Nervous system
8.4
6.8
14
17
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.2
6.8
17
28
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.0
6.8
37
128
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
6.7
115
674
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.3
6.6
56
248
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.9
6.6
38
134
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.6
182
1229
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.2
6.5
16
26
G41.0
ICD-10 Finland
Grand mal status epilepticus
70.4
6.4
7
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
6.4
66
320
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.6
6.3
45
182
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.9
6.3
24
63
M79.6
ICD-10 Finland
Pain in limb
1.5
6.3
237
1725
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
26.9
6.2
8
*
N05AF03
ATC
chlorprothixene; systemic
3.5
6.1
26
75
R25.2
ICD-10 Finland
Cramp and spasm
4.1
6.1
22
55
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.1
53
240
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
214
84
32.87
317.33
4.2
6.2
388.6
375.3
umol/l
0.32
196
74
51
17
31.70
77.78
3.3
1.7
16.6
13.7
umol/l
0.78
51
17
291
1653
2.11
22.75
2.5
2.0
201.1
226.6
u/l
0.23
284
1567
422
3025
1.73
14.50
6.2
7.4
1.2
1.2
mmol/l
1.95
364
2620
510
3861
1.72
14.28
5.1
4.9
6.5
6.5
mmol/l
0.03
467
3522
377
2737
1.64
11.58
5.7
7.1
1.2
1.2
mmol/l
2.42
351
2510
113
625
1.92
8.81
2.7
2.5
27.4
37.9
u/l
1.85
101
522
324
2392
1.55
8.64
3.5
3.3
31.6
31.5
u/l
0.01
306
2282
407
3271
1.44
6.66
5.7
6.0
9.9
12.1
umol/l
1.66
374
3097
296
2261
1.46
6.28
1.9
1.8
98.3
96.9
pmol/l
0.19
159
1202
584
5051
1.43
6.13
6.7
6.7
78.4
81.2
u/l
0.83
539
4756
781
7165
1.59
5.96
14.9
12.2
139.2
139.6
mmol/l
3.62
758
6976
276
2100
1.45
5.91
3.0
3.1
19.0
29.9
ng/l
1.87
137
1165
263
1987
1.45
5.84
2.6
2.5
53.3
56.4
u/l
0.48
243
1847
157
1074
1.56
5.62
1.9
1.8
1.4
1.4
%
0.00
146
983
321
2545
1.40
5.37
4.6
5.2
36.1
36.7
g/l
1.11
295
2384
779
7190
1.54
5.27
14.8
12.3
4.0
3.9
mmol/l
1.00
752
6983
105
664
1.66
5.20
4.1
6.2
0.8
1.6
mmol/l
1.15
84
519
493
4220
1.36
5.04
9.9
8.8
4.0
4.0
e9/l
0.04
420
3671
13
32
4.11
4.91
1.8
5.2
231.5
204.1
umol/l
—
6
17
153
1072
1.51
4.89
3.5
3.3
510.4
635.3
ng/l
0.12
100
695
57
307
1.91
4.86
1.4
1.5
—
—
—
0
0
104
668
1.63
4.85
4.1
6.2
5.7
5.8
kpa
0.61
96
649
259
2028
1.39
4.54
2.5
3.0
2.3
2.4
mmol/l
0.52
225
1819
74
446
1.72
4.40
4.0
6.8
23.5
23.7
mmol/l
0.40
67
421
571
5060
1.34
4.33
3.8
3.0
48.3
40.2
u/l
1.91
548
4828
346
2854
1.34
4.30
2.4
2.5
72.1
73.2
nmol/l
0.30
313
2645
239
1866
1.38
4.23
3.3
3.4
7.3
8.1
mmol/l
1.49
198
1624
86
562
1.58
3.76
4.3
6.8
5.2
5.0
kpa
0.77
78
531
83
542
1.58
3.65
4.3
7.0
0.8
1.4
mmol/l
1.07
62
395
816
7741
1.47
3.46
10.4
8.7
26.8
26.7
u/l
0.08
784
7510
46
260
1.81
3.45
1.1
1.1
1.3
6.2
u/ml
—
7
45
52
306
1.74
3.41
1.3
1.3
—
—
—
0
0
88
598
1.52
3.26
2.3
2.9
0.2
0.2
g/l
1.15
83
568
165
1269
1.37
3.15
1.5
1.5
22.3
20.9
nmol/l
0.49
148
1118
128
947
1.41
3.08
1.7
1.8
—
—
—
0
0
86
590
1.50
3.06
3.7
6.0
4.9
4.8
kpa
0.15
78
572
13
45
2.92
3.03
1.4
1.2
1.8
1.7
mmol/l
0.07
13
45
194
1557
1.31
2.77
1.7
2.1
1.7
1.2
mg/l
0.37
140
1151
26
135
1.95
2.57
1.1
1.2
79.2
152.0
iu/ml
—
5
45
81
572
1.46
2.53
2.0
2.3
7838.8
5439.8
u/l
0.21
35
249
192
1566
1.29
2.42
3.4
3.3
1.0
1.0
kg/l
0.34
30
221
7
18
3.91
2.25
5.3
3.5
—
—
—
0
0
7
18
3.91
2.25
5.3
3.5
—
—
—
0
0
117
903
1.34
2.20
1.8
1.6
1041.4
1172.8
nmol/l
0.95
87
694
32
188
1.73
2.19
1.3
1.3
300.7
321.4
ug/g
0.21
18
105
61
421
1.48
2.17
1.8
1.7
—
—
—
0
0
9
30
3.02
2.15
1.2
1.2
—
—
—
0
0
9
30
3.02
2.15
1.2
1.2
—
—
—
0
0
77
560
1.41
2.09
8.3
9.7
1.3
0.8
mmol/l
0.36
65
447
244
2081
1.23
2.08
1.4
1.4
1.9
1.8
u/ml
0.06
49
539
23
127
1.83
1.95
1.1
1.2
2.1
5.0
u/ml
—
9
43
503
4626
1.19
1.91
4.1
3.9
656.8
775.1
e6/l
0.09
12
67
16
79
2.04
1.86
1.4
1.4
—
—
—
0
0
62
444
1.42
1.86
1.5
1.5
274.7
297.5
mu/l
0.41
55
398
85
644
1.35
1.83
1.7
1.7
—
—
—
0
0
5
12
4.18
1.82
1.2
1.2
—
—
—
0
0
182
1527
1.24
1.80
4.5
4.1
16.4
21.8
mg/mmol
0.17
125
1003
7
23
3.06
1.80
1.4
2.2
199.3
210.5
u/l
—
7
23
9
36
2.51
1.74
1.7
1.7
—
—
—
0
0
9
36
2.51
1.74
1.7
1.7
—
—
—
0
0
9
36
2.51
1.74
1.7
1.7
—
—
—
0
0
9
36
2.51
1.74
1.7
1.7
—
—
—
0
0
773
7435
1.25
1.68
14.2
11.2
20.9
21.5
mg/l
0.16
621
5706
15
76
1.99
1.65
1.4
1.4
—
—
—
0
0
22
128
1.74
1.61
1.1
1.2
2.3
5.8
u/ml
—
8
55
10
43
2.34
1.60
1.1
1.0
—
—
—
0
0
15
77
1.96
1.60
1.4
1.4
—
—
—
0
0
15
77
1.96
1.60
1.4
1.4
—
—
—
0
0
15
77
1.96
1.60
1.4
1.4
—
—
—
0
0
84
651
1.32
1.58
1.6
1.8
—
—
—
0
0
651
6824
0.84
1.56
4.0
3.7
4.7
4.7
mmol/l
0.03
612
6464
27
169
1.62
1.53
4.6
6.2
23.7
24.3
mmol/l
0.32
22
151
23
139
1.67
1.49
1.5
1.3
—
—
—
0
0
39
268
1.48
1.48
1.2
1.2
1.5
2.0
u/ml
0.14
16
133
69
525
1.34
1.48
7.1
9.5
1.4
1.4
mmol/l
0.24
64
498
601
5680
1.17
1.45
4.2
3.9
14.2
14.5
pmol/l
1.96
550
5263
27
172
1.59
1.44
1.0
1.1
8.7
8.5
u/ml
0.01
12
83
699
6688
1.19
1.44
5.0
4.5
1.9
2.0
mu/l
0.35
646
6266
25
385
0.64
1.41
1.2
1.8
3.4
3.5
mg/l
0.06
14
254
21
126
1.68
1.41
1.1
1.1
—
—
—
0
0
26
166
1.58
1.38
1.0
1.1
0.2
0.4
u/ml
—
6
58
6
23
2.62
1.37
1.2
1.2
—
—
—
0
0
650
6786
0.86
1.33
3.9
3.6
1.4
1.5
mmol/l
0.88
608
6399
546
5145
1.15
1.30
3.7
3.8
10.2
9.8
mm/h
0.34
500
4805
661
6886
0.86
1.29
4.3
4.0
2.8
2.8
mmol/l
0.04
619
6470
674
6453
1.17
1.27
10.9
9.5
95.6
90.8
ml/min/173m2
6.21
528
5130
28
186
1.52
1.27
1.0
1.1
1.5
8.5
u/ml
3.25
15
91
193
1686
1.18
1.27
2.0
2.2
2.6
2.8
mg/l
0.62
157
1456
16
92
1.75
1.25
1.3
1.3
—
—
—
0
0
35
245
1.45
1.25
2.0
1.8
—
—
—
0
0
109
905
1.23
1.22
5.6
7.0
1.1
1.1
mmol/l
0.15
103
851
179
1562
1.18
1.19
2.3
2.7
7222.1
5813.2
umol/l
0.11
153
1392
65
822
0.77
1.19
1.9
2.5
0.8
0.7
ug/l
0.15
37
454
6
26
2.32
1.19
2.0
1.8
—
—
—
0
0
6
26
2.32
1.19
2.0
1.8
—
—
—
0
0
22
141
1.57
1.18
6.3
3.8
17.9
30.2
mg/l
1.73
15
96
14
79
1.78
1.17
1.4
1.4
—
—
—
0
0
10
50
2.01
1.16
1.7
1.6
—
—
—
0
0
70
556
1.28
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.5
13.4
7.7
ug/l
—
5
20
8
40
2.01
1.12
1.0
1.1
—
—
—
0
0
8
40
2.01
1.12
1.6
2.8
—
—
—
0
0
152
1317
1.18
1.11
2.7
3.3
791.3
985.8
ng/l
0.45
115
1100
7
33
2.13
1.05
1.1
1.2
—
—
—
0
0
628
6528
0.88
1.02
3.5
3.3
1.3
1.3
mmol/l
1.84
588
6150
31
222
1.41
1.01
1.6
1.6
—
—
—
0
0
5
107
0.46
1.01
1.2
1.6
—
—
—
0
0
120
1030
1.19
0.99
2.1
2.9
6.8
2.8
e6/l
0.94
55
552
63
506
1.26
0.98
1.5
1.5
22.5
22.5
iu/l
0.00
55
419
12
69
1.75
0.96
1.9
2.0
—
—
—
0
0
64
517
1.26
0.95
1.2
1.4
—
—
—
0
0
11
62
1.78
0.94
1.0
1.2
—
—
—
0
0
6
27
2.23
0.93
2.0
1.8
—
—
—
0
0
37
279
1.34
0.91
9.1
12.3
24.0
24.1
mmol/l
0.08
37
265
11
63
1.76
0.90
1.0
1.2
—
—
—
0
0
12
71
1.70
0.89
1.0
1.1
181.5
235.4
mg/l
0.71
12
61
26
187
1.40
0.86
1.7
1.2
17.3
8.6
u/ml
—
7
30
18
120
1.51
0.86
1.2
1.5
7.9
7.3
mmol/l
0.35
13
80
95
1107
0.84
0.85
2.9
3.5
21.7
21.8
%
0.01
31
430
106
914
1.18
0.85
2.1
2.4
2.4
2.4
g/l
0.09
98
843
23
163
1.42
0.82
1.3
2.1
3.8
3.6
mmol/l
0.33
23
153
78
656
1.21
0.82
1.2
1.2
145.9
156.9
iu/ml
0.08
20
271
55
446
1.25
0.81
3.1
4.8
85.1
72.5
ng/l
0.35
45
409
10
163
0.61
0.79
4.0
2.6
—
—
—
0
0
11
66
1.67
0.79
1.0
1.0
—
—
—
0
0
169
1871
0.88
0.77
3.3
3.4
0.0
0.0
estimate
1.08
55
663
32
415
0.76
0.77
1.5
1.6
—
—
—
0
0
122
1075
1.16
0.76
2.1
2.7
1.1
0.9
e6/l
0.44
56
592
11
67
1.65
0.75
1.1
1.1
—
—
—
0
0
49
399
1.24
0.72
2.0
2.2
12.0
7.9
ug/l
0.19
37
359
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
130
1158
1.14
0.70
1.6
1.6
421.3
25618624.0
pmol/l
1.32
108
1011
43
346
1.25
0.70
1.6
1.6
7.8
8.5
u/l
0.13
33
276
11
69
1.60
0.68
4.4
2.4
106.0
105.8
mmol/l
0.08
11
69
11
69
1.60
0.68
4.4
2.4
4.1
4.0
mmol/l
0.20
11
69
9
59
1.53
0.68
1.7
1.6
—
—
—
0
0
9
59
1.53
0.68
1.7
1.6
—
—
—
0
0
9
59
1.53
0.68
1.7
1.6
—
—
—
0
0
78
671
1.18
0.67
4.1
3.5
31.8
31.7
%
0.01
55
487
5
92
0.54
0.67
1.2
1.7
—
—
—
0
0
133
1479
0.88
0.66
1.4
1.5
—
—
—
0
0
7
44
1.60
0.65
2.9
2.4
—
—
—
0
0
34
269
1.27
0.64
1.4
1.3
—
—
—
0
0
675
6579
1.10
0.60
18.5
13.8
13.3
13.4
%
2.21
662
6470
15
105
1.44
0.60
2.5
2.5
16.0
16.8
%
—
6
59
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
24
183
1.32
0.60
3.5
1.9
0.7
2.6
ug/l
0.63
19
163
94
830
1.15
0.59
2.2
2.5
25.2
23.2
%
0.58
76
736
51
428
1.20
0.59
1.6
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
5
86
0.58
0.56
1.0
1.4
—
—
—
0
0
91
807
1.14
0.55
3.2
3.4
5.7
7.2
umol/l
0.54
71
683
14
194
0.72
0.55
1.8
2.0
—
—
—
0
0
13
182
0.71
0.54
1.8
1.7
—
—
—
0
0
11
74
1.49
0.53
1.4
1.4
24.7
38.5
nmol/l
0.66
11
66
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
29
359
0.80
0.52
1.9
1.7
—
—
—
0
0
10
66
1.52
0.52
1.2
1.2
5.5
5.5
umol/l
—
10
59
127
1393
0.90
0.52
2.9
3.8
1.6
2.0
ug/l
0.62
113
1276
79
697
1.15
0.52
1.7
2.1
407.0
369.1
nmol/l
0.77
72
660
21
161
1.31
0.52
1.0
1.1
2.5
1.7
u/ml
—
8
73
6
40
1.50
0.51
1.5
1.6
—
—
—
0
0
18
135
1.34
0.51
2.4
2.0
—
—
—
0
0
746
7324
1.10
0.51
16.4
12.2
39.4
40.3
%
2.17
594
6018
33
270
1.23
0.50
1.2
1.1
—
—
—
0
0
840
8491
0.88
0.49
21.9
16.5
135.4
136.1
g/l
0.72
832
8394
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
45
1.56
0.49
1.0
1.1
—
—
—
0
0
179
1669
1.09
0.46
2.3
2.2
—
—
—
0
0
5
84
0.59
0.45
1.0
1.0
—
—
—
0
0
5
85
0.59
0.45
1.2
1.6
—
—
—
0
0
66
583
1.14
0.44
12.2
17.3
1.1
1.2
inr
0.37
14
88
9
127
0.71
0.43
1.8
1.7
—
—
—
0
0
11
78
1.42
0.43
1.1
1.5
—
—
—
0
0
5
31
1.62
0.43
1.0
1.3
—
—
—
0
0
242
2293
1.08
0.42
2.5
3.3
—
—
—
0
0
108
988
1.11
0.42
2.1
2.4
14.4
13.9
umol/l
0.26
99
918
131
1212
1.09
0.41
1.2
1.3
25.2
26.9
iu/ml
0.07
45
371
53
465
1.15
0.40
2.2
3.5
4.6
4.8
pmol/l
0.76
46
414
21
168
1.26
0.40
1.4
2.1
3.8
3.7
g/l
0.06
15
130
21
168
1.26
0.40
1.4
2.1
—
—
—
0
0
8
112
0.71
0.37
1.0
1.1
—
—
—
0
0
15
116
1.30
0.37
1.6
1.5
—
—
—
0
0
16
125
1.28
0.37
7.6
4.1
53.6
55.7
%
0.23
16
125
182
1717
1.07
0.36
2.3
2.3
—
—
—
0
0
64
574
1.12
0.36
2.6
2.7
—
—
—
0
0
26
217
1.20
0.36
1.2
1.3
—
—
—
0
0
5
78
0.64
0.35
2.4
1.8
—
—
—
0
0
17
135
1.26
0.35
2.5
2.6
123.5
132.1
g/l
0.98
12
105
176
1661
1.07
0.35
1.8
1.7
1.5
1.4
mmol/l
0.57
148
1442
16
126
1.27
0.35
2.2
2.5
30.8
105.3
ug/min
—
8
78
61
547
1.12
0.35
2.3
2.1
10.1
12.8
nmol/l
1.92
51
490
27
319
0.84
0.35
1.4
1.5
—
—
—
0
0
36
311
1.16
0.34
1.8
1.7
—
—
—
0
0
78
851
0.91
0.32
2.0
1.9
—
—
—
0
0
41
361
1.14
0.32
1.3
1.4
—
—
—
0
0
19
156
1.22
0.31
1.3
1.1
—
—
—
0
0
7
98
0.71
0.31
2.0
1.7
—
—
—
0
0
142
1338
1.07
0.30
2.2
2.6
8.2
6.8
e6/l
0.36
123
1174
16
129
1.24
0.30
3.6
5.4
—
2352.7
—
0
12
12
93
1.29
0.30
1.3
1.4
—
—
—
0
0
15
185
0.81
0.30
1.3
1.5
—
—
—
0
0
19
157
1.21
0.29
1.4
1.3
—
—
—
0
0
14
112
1.25
0.28
1.0
2.1
—
1474.3
—
0
7
27
233
1.16
0.27
1.1
1.2
—
—
—
0
0
9
118
0.76
0.27
1.3
1.2
—
—
—
0
0
9
120
0.75
0.27
1.1
1.5
—
—
—
0
0
8
65
1.23
0.27
1.0
1.1
—
—
—
0
0
15
122
1.23
0.27
8.1
3.9
3.9
4.2
e9/l
0.14
15
122
71
655
1.09
0.26
4.2
5.9
—
—
—
0
0
37
415
0.89
0.26
2.2
1.9
—
—
—
0
0
103
966
1.07
0.26
2.4
2.6
2.4
2.4
mmol/l
0.39
88
843
225
2166
1.05
0.25
1.9
1.7
—
—
—
0
0
26
297
0.87
0.24
1.4
1.5
—
—
—
0
0
162
1548
1.06
0.24
2.2
2.1
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
40.8
32.5
u/l
—
5
29
5
38
1.32
0.23
1.0
1.1
97.4
104.8
u/l
—
5
29
84
895
0.93
0.22
1.5
1.6
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
135
1.19
0.21
3.8
4.6
0.3
0.3
u/ml
—
7
74
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
0.5
—
0
11
0
10
0.00
0.21
0.0
8.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
25
220
1.14
0.21
1.4
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
2.6
—
0
5
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
26
230
1.13
0.20
1.1
1.2
—
—
—
0
0
10
80
1.25
0.20
1.1
1.7
—
—
—
0
0
23
202
1.14
0.20
1.1
1.2
—
—
—
0
0
12
99
1.21
0.19
1.7
1.5
—
—
—
0
0
122
1165
1.05
0.19
1.3
1.2
3.6
10.5
u/ml
1.60
39
470
323
3305
0.97
0.19
4.6
4.1
—
—
—
0
0
186
1797
1.04
0.19
2.5
3.1
0.3
0.3
e6/l
0.11
138
1325
24
213
1.13
0.18
2.3
2.9
6.5
6.7
umol/l
0.03
19
163
46
425
1.09
0.18
3.7
3.3
1.2
1.2
mmol/l
0.15
41
366
61
571
1.07
0.18
1.3
1.3
132.6
243.9
u/ml
1.22
55
533
7
60
1.17
0.18
2.3
2.3
—
—
—
0
0
17
195
0.87
0.17
1.4
1.5
—
—
—
0
0
29
320
0.90
0.17
1.4
1.4
—
—
—
0
0
6
78
0.77
0.15
1.2
1.5
—
—
—
0
0
10
83
1.21
0.15
1.6
2.0
—
—
—
0
0
11
93
1.19
0.14
1.0
1.3
—
—
—
0
0
8
97
0.82
0.13
1.1
1.5
—
—
—
0
0
51
481
1.06
0.13
1.9
2.5
75.0
73.1
ml/min/173m2
0.12
18
181
359
3535
1.03
0.13
4.9
4.5
0.0
0.0
estimate
0.50
59
680
16
142
1.13
0.12
1.3
1.3
—
—
—
0
0
16
142
1.13
0.12
1.3
1.3
—
—
—
0
0
47
443
1.06
0.12
1.3
1.4
—
—
—
0
0
17
152
1.12
0.12
1.4
2.3
2.1
0.6
g/l
0.54
17
139
47
444
1.06
0.12
1.3
1.4
—
—
—
0
0
57
542
1.06
0.12
1.5
1.5
—
—
—
0
0
362
3570
1.02
0.11
3.4
3.2
0.0
0.0
estimate
0.50
56
653
47
445
1.06
0.11
1.3
1.4
—
—
—
0
0
47
446
1.06
0.10
1.3
1.4
—
—
—
0
0
269
2732
0.98
0.10
3.4
3.2
—
—
—
0
0
356
3517
1.02
0.09
3.3
3.2
0.0
0.0
estimate
0.50
58
659
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
50
479
1.05
0.08
1.2
1.5
—
—
—
0
0
10
88
1.14
0.08
1.0
1.1
—
—
—
0
0
8
74
1.08
0.07
4.0
2.9
—
—
—
0
0
9
84
1.07
0.07
1.0
1.1
—
—
—
0
0
10
89
1.12
0.07
1.0
1.1
—
—
—
0
0
47
453
1.04
0.06
4.6
4.3
3.5
41.3
ug/l
1.34
41
374
9
101
0.89
0.06
2.1
2.8
5.7
8.0
u/ml
—
9
91
82
840
0.97
0.06
1.4
1.5
—
—
—
0
0
617
6199
0.99
0.06
3.7
3.6
—
—
—
0
0
599
6019
0.99
0.06
5.6
4.6
39.3
38.5
mmol/mol
0.92
554
5681
38
395
0.96
0.05
1.3
1.3
241.6
256.1
miu/ml
0.11
19
194
24
253
0.95
0.05
1.4
1.5
1.0
1.2
g/l
1.02
19
239
22
208
1.06
0.05
1.2
1.3
3.0
3.2
ug/l
0.09
22
191
22
231
0.95
0.04
1.5
1.5
290.2
212.6
u/ml
0.44
14
127
17
160
1.06
0.04
1.2
1.1
—
—
—
0
0
107
1054
1.02
0.04
2.3
2.0
—
—
—
0
0
14
131
1.07
0.03
1.1
1.4
—
—
—
0
0
11
118
0.93
0.02
1.6
1.7
8.5
7.3
mmol/l
—
6
74
13
138
0.94
0.02
1.3
2.1
39.2
39.5
g/l
0.07
13
125
358
3593
0.99
0.02
3.0
2.9
116.8
88.1
ug/l
0.68
333
3386
25
243
1.03
0.01
1.6
1.6
0.1
0.3
iu/ml
—
10
44
18
184
0.98
0.00
1.4
1.7
—
—
—
0
0
13
128
1.02
0.00
1.3
2.2
0.0
0.0
g/l
0.00
13
121
14
138
1.01
0.00
1.3
2.2
0.0
0.0
g/l
0.50
14
130
24
238
1.01
0.00
1.4
1.5
—
—
—
0
0
657
6573
1.00
0.00
4.0
3.6
5.8
5.7
mmol/l
0.98
611
6106
15
147
1.02
0.00
1.3
1.2
—
—
—
0
0
13
129
1.01
0.00
1.3
2.2
0.0
0.0
g/l
0.00
13
121
24
245
0.98
0.00
1.6
1.5
0.2
0.2
g/l
2.84
19
233
5
53
0.94
0.00
3.0
3.2
30.6
25.1
umol/l
—
5
53
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
9.8
—
20.4
—
0
5
15
150
1.00
0.00
1.5
1.4
6.8
18.9
u/l
—
9
130
6
67
0.89
0.00
1.2
1.2
—
—
—
0
0
6
67
0.89
0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
4.2
—
4.6
—
0
6
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
66
0.91
0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint GE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 3.042 [2.55, 3.62] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.156 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 3730 females with GE_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 2.983 [2.53, 3.52] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 387 out of 3234 males with GE_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have GE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.259% | 0.522% |
| 5 | 1.7% | 3.308% |
| 10 | 4.063% | 8.705% |
| 15 | 8.056% | 15.884% |
| 20 | 14.044% | 25.461% |
Relationships between endpoints
↥Index endpoint: GE_STRICT – Generalized epilepsy, strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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