Periodontal disease, other/unspecified

K11_PERIODONTAL_NOS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K05.5, K05.6 Hospital discharge: ICD-9 — 523[6-9] Hospital discharge: ICD-8 — 523[6-9] Cause of death: ICD-10 — K05.5, K05.6 Cause of death: ICD-9 — 523[6-9] Cause of death: ICD-8 — 523[6-9] 2 out of 7 registries used, show all original rules.	133
4. Check minimum number of events None	133
5. Include endpoints None	133
6. Filter based on genotype QC (FinnGen only)	133

Control definitions (FinnGen only)

Control exclude: K11_GINGIVITIS_PERIODONTAL

Extra metadata

First used in FinnGen datafreeze: DF5

NAME	K11_PERIODONTAL_NOS
CONTROL_EXCLUDE	K11_GINGIVITIS_PERIODONTAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K05[5-6]
HD_ICD_9	523[6-9]
HD_ICD_8	523[6-9]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K05[5-6]
COD_ICD_9	523[6-9]
COD_ICD_8	523[6-9]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Periodontal disease, other/unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1191	575	607
Only index persons	1018	487	531
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	45.87	49.92	41.85
Only index persons	43.14	47.83	38.84

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	133	62	71
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	54.12	52.73	55.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
117: Matched controls
1171

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K05.6

ICD-10 Finland

Periodontal disease, unspecified

+∞

66.0

K05.5

ICD-10 Finland

Other periodontal diseases

+∞

43.5

K05.30

ICD-10 Finland

Periodontitis complex

+∞

38.7

K05.31

ICD-10 Finland

Periodontitis pronounced

+∞

21.5

K05.10

ICD-10 Finland

Gingivitis (chronic) NOS

+∞

21.5

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

40.3

18.8

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

5.6

16.9

247

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

29.8

15.3

SAA03

NOMESCO Finland

Extended examination of mouth

4.4

12.9

243

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

15.8

12.5

SBB10

NOMESCO Finland

Teeth copy

11.2

12.2

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

4.3

11.5

195

52398

ICD-8 Finland

Periodontal diseases, Alii definiti

+∞

10.6

SBA00

NOMESCO Finland

Microbiological examinations

26.2

10.5

SBB20

NOMESCO Finland

Tooth X-ray examination in conjunction with visit to dentist

108.4

9.6

EBA10

NOMESCO Finland

Surgical removal of tooth

6.7

9.4

SAA04

NOMESCO Finland

Special inverstigation of mouth

9.2

9.3

K03.66

ICD-10 Finland

Tooth plaque

12.1

9.1

WZB00

NOMESCO Finland

Telephone receipt or other advice

3.8

9.1

170

K05.1

ICD-10 Finland

Chronic gingivitis

+∞

8.4

SDA03

NOMESCO Finland

Demanding parodonthologic therapy

3.6

8.2

162

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

5.6

7.9

K04.5

ICD-10 Finland

Chronic apical periodontitis

3.7

7.9

134

K05.39

ICD-10 Finland

Periodontitis UNS

+∞

7.4

SPC20

NOMESCO Finland

Attachment of crone of tooth to implant

32.2

7.3

SAA02

NOMESCO Finland

Basic examination of mouth

2.9

7.1

417

EBA15

NOMESCO Finland

Extraction of large number of teeth

12.0

7.0

EBA00

NOMESCO Finland

Extraction of tooth

3.1

6.8

198

T84.62

ICD-10 Finland

Osteitis associated with dental implants

73.7

6.5

SXC05

NOMESCO Finland

Other oral or dental procedure

7.8

6.4

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

19.3

6.4

SCA01

NOMESCO Finland

Simple analysis and advice of nutrition with regard to dentistry

3.3

6.3

128

EBB15

NOMESCO Finland

Insertion of dental implant abutment

28.4

6.3

SXC02

NOMESCO Finland

Other oral or dental procedure, restricted

28.4

6.3

SXC03

NOMESCO Finland

Other oral or dental procedure

+∞

6.3

K05.18

ICD-10 Finland

Chronic gingivitis

+∞

6.3

EB1AD

NOMESCO Finland

Cone beam CT of teeth and jaws (one quarter)

+∞

6.3

SDA01

NOMESCO Finland

Simple parodonthologic therapy

3.4

6.1

117

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

328

3.50

11.56

6.3

6.5

—

(3019198) Lymphocytes [#/volume] in Blood

506

2.88

7.93

7.2

6.6

1.80

1.79

e9/l

0.04

447

(3001604) Monocytes [#/volume] in Blood

497

2.78

7.51

7.3

6.5

0.65

0.57

e9/l

2.13

430

(3006315) Basophils [#/volume] in Blood

498

2.77

7.46

7.3

6.6

0.04

e9/l

0.49

433

(3013115) Eosinophils [#/volume] in Blood

514

2.64

6.75

7.5

6.7

0.16

0.19

e9/l

1.02

446

(3024928) Oxygen saturation in Venous blood

5.62

5.63

4.8

2.5

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

141

2.78

5.56

3.6

2.5

22.00

23.33

0.17

125

(3023368) Bacteria identified in Blood by Culture

296

2.39

5.42

5.6

4.5

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

137

2.76

5.36

12.0

6.5

1.05

mmol/l

0.03

128

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

397

2.32

5.33

2.1

1.9

112.19

92.36

pmol/l

1.34

199

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

228

2.39

4.94

2.6

2.5

2.21

3.18

mg/l

2.60

200

(3013650) Neutrophils [#/volume] in Blood by Automated count

590

2.29

4.94

13.0

9.2

4.03

4.17

e9/l

0.21

521

(3026389) Candida sp identified in Specimen by Organism specific culture

10.54

4.58

2.6

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

184

2.40

4.51

2.0

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.92

4.12

2.9

1.7

—

(3023520) Reticulocytes [#/volume] in Blood

2.82

4.03

2.2

3.9

67.71

70.76

e9/l

0.14

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

4.04

3.89

1.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

145

2.38

3.85

2.9

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

350

2.04

3.80

2.6

2.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

126

2.43

3.74

1.9

1.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

423

1.99

3.68

3.7

2.7

218.32

132.07

ug/l

0.43

390

(3007853) Bacteria identified in Skin by Aerobe culture

120

2.45

3.68

1.7

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.75

3.57

9.3

4.2

104.11

74.79

ng/l

0.65

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

501

1.95

3.52

5.8

4.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

258

2.05

3.51

2.6

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

6.00

3.39

1.0

—

(3021960) Folate [Moles/volume] in Serum or Plasma

230

2.06

3.34

1.9

1.5

19.07

20.87

nmol/l

0.39

192

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

112

2.39

3.31

1.8

3.3

7.36

7.07

umol/l

0.03

103

(3032080) INR in Blood by Coagulation assay

426

1.91

3.30

12.7

7.3

1.23

1.24

inr

0.03

121

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

412

1.89

3.18

4.2

3.0

—

(3021788) Differential panel - Synovial fluid

6.09

3.06

2.0

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.74

2.90

1.4

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

126

2.21

2.89

2.0

1.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

652

1.84

2.84

8.1

4.8

7.07

6.75

mmol/l

0.56

601

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

107

2.27

2.76

4.8

3.3

—

(40768797) Stomach Pathology biopsy report

136

2.13

2.75

1.5

1.3

—

(3002256) Pathology report gross observation

116

2.19

2.65

1.5

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

4.86

2.63

1.1

—

(3017704) Immunofixation for Urine

7.36

2.57

1.2

1.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

7.36

2.57

2.6

5.3

5.48

4.83

e9/l

—

(3026782) Osmolality of Urine

211

1.89

2.50

3.5

2.4

519.53

573.12

mosm/kgh2o

0.70

185

(3014148) Varicella zoster virus Ab [Titer] in Serum

5.18

2.43

1.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

222

1.85

2.39

5.3

3.3

303.16

287.74

ng/l

0.03

175

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

6.44

2.39

2.8

5.3

61.20

64.50

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

107

2.14

2.36

2.6

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.37

2.35

2.2

1.7

—

(3026008) Bacteria identified in Urine by Culture

316

1.75

2.35

4.3

3.1

—

(36660697) Celiac disease serology panel - Serum

2.35

2.32

1.4

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

508

1.69

2.32

15.1

7.3

1.21

mmol/l

0.08

432

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.49

2.31

12.4

9.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.92

2.25

1.6

1.9

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

5.72

2.23

1.4

1.1

—

(3044941) Cell count panel - Synovial fluid

5.72

2.23

1.2

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.43

2.17

1.3

1.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

192

1.80

2.01

1.9

1.7

1088.14

1197.42

nmol/l

0.30

144

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.25

2.01

6.1

9.6

23.61

24.94

mmol/l

0.72

(3027315) Oxygen [Partial pressure] in Blood

3.46

1.99

1.3

2.7

8.87

8.40

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.46

1.99

1.3

2.7

4.91

4.92

kpa

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

169

1.83

1.97

1.9

2.8

29.60

29.21

0.15

162

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

4.68

1.96

4.0

2.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

4.68

1.96

1.0

1.5

—

(3022806) Fractional oxyhemoglobin in Capillary blood

4.68

1.96

1.0

1.4

90.90

88.65

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.30

1.91

2.1

1.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.30

1.91

2.1

1.5

—

(1761868) Lipid panel - Serum or Plasma

402

0.56

1.88

3.5

2.8

—

(40768804) Tissue Pathology biopsy report

406

1.60

1.86

2.8

2.1

—

(3018418) pH of Serum or Plasma

316

1.64

1.86

9.1

4.0

7.38

7.40

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

4.28

1.84

2.0

3.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

4.28

1.84

1.2

1.0

—

(3037756) Immunofixation for Serum or Plasma

3.15

1.82

2.0

1.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.15

1.82

1.1

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.15

1.82

2.4

1.2

—

(40768443) Skin Pathology biopsy report

2.87

1.82

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

363

1.60

1.80

4.7

3.1

30.18

31.96

u/l

0.32

350

(40758558) Short blood count panel - Blood

267

1.65

1.77

10.1

7.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

112

1.92

1.76

4.2

2.1

331.70

371.01

nmol/l

0.42

104

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.95

1.73

1.0

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

3.26

1.68

3.0

2.0

54.33

65.12

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.67

1.63

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

213

1.66

1.61

2.2

1.8

516.92

433.63

pmol/l

0.98

178

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.78

1.60

2.0

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.09

1.60

1.0

1.3

—

(1616796) Gas panel - Central venous blood

3.09

1.60

2.7

3.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.09

1.60

4.3

3.0

—

(3000991) Gas panel - Venous blood

102

1.88

1.54

12.5

9.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

182

1.68

1.53

1.3

1.8

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

3.42

1.53

1.0

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

174

1.69

1.53

4.1

2.8

9.17

2.22

e6/l

0.39

(3002582) Erythrocytes [#/volume] in Urine

348

1.54

1.52

4.7

2.8

76.01

53.60

e6/l

0.18

263

(3037467) Urinalysis macro (dipstick) panel - Urine

735

1.53

1.51

8.5

4.4

—

(3012544) pH of Venous blood

119

1.80

1.48

10.7

4.9

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.58

1.47

1.7

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.00

1.45

3.9

4.8

0.40

0.38

—

(3011412) CD3 cells [#/volume] in Blood

3.20

1.45

4.0

1.9

1.33

0.99

e9/l

—

(3037522) Nuclear Ab [Titer] in Serum

136

1.74

1.44

1.8

1.5

420.00

332.80

titre

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.49

1.41

1.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.49

1.41

1.3

1.1

—

(3003396) Base excess in Arterial blood by calculation

130

1.73

1.37

10.8

7.6

1.32

1.15

mmol/l

0.08

103

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

1.37

0.0

1.2

—

0.87

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.22

1.36

1.7

—

(3019225) pH of Specimen

1.89

1.33

6.2

5.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.57

1.32

1.3

1.4

—

(3021901) Oxygen saturation in Capillary blood

2.57

1.32

2.5

2.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

148

1.67

1.31

2.5

1.6

—

(3003181) Sodium [Moles/volume] in Urine

2.84

1.29

2.0

1.2

43.20

54.67

mmol/l

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.84

1.29

2.2

1.2

—

(3018095) Leukocytes [#/volume] in Urine

397

1.46

1.27

5.9

3.3

85.25

88.27

e6/l

0.02

285

(3021589) Normoblasts [#/volume] in Blood

482

1.45

1.27

13.8

10.0

0.00

e9/l

0.99

398

(36304419) Bacteria [Presence] in Urine

306

1.49

1.26

4.9

2.7

—

(3025941) Bacteria identified in Stool by Culture

2.01

1.21

1.5

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.17

1.20

1.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.41

1.14

1.3

1.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.81

1.14

3.4

2.4

64.58

65.40

g/l

0.16

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

285

1.47

1.13

1.9

1.7

1.43

1.36

mmol/l

0.19

237

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

414

1.42

1.13

6.1

3.9

18.41

33.94

ng/l

1.77

288

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.33

1.12

1.7

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.25

1.10

3.1

2.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.25

1.10

1.6

1.7

—

(3000963) Hemoglobin [Mass/volume] in Blood

115

1216

0.60

1.09

42.3

20.4

133.09

136.94

g/l

1.83

115

1197

(3024731) MCV [Entitic volume]

115

1216

0.60

1.09

41.8

20.2

92.10

90.89

2.13

115

1198

(3007164) IgA [Mass/volume] in Serum or Plasma

216

1.50

1.08

2.0

1.5

2.35

2.77

g/l

0.46

143

(3021440) Promyelocytes/100 leukocytes in Blood

1.81

1.07

3.9

5.0

0.00

0.20

—

(3035941) MCH [Entitic mass]

115

1215

0.60

1.06

41.7

20.2

30.65

30.32

1.26

115

1197

(3007461) Platelets [#/volume] in Blood

115

1215

0.60

1.06

42.2

20.3

249.75

242.85

e9/l

0.59

115

1183

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.02

1.06

1.6

1.9

—

(3049717) Cytology report of Urine Cyto stain

2.02

1.06

3.9

2.4

—

(40761535) Cells panel - Urine sediment

1.73

1.06

2.6

3.2

—

(1002224) Polysomnography panel

2.12

1.04

1.0

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

2.12

1.04

1.9

3.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.32

1.04

1.4

1.7

—

(3017181) Myelocytes/100 leukocytes in Blood

1.75

1.02

3.7

4.7

1.00

—

(3000494) Fungus identified in Specimen by Culture

133

1.59

1.02

2.0

1.5

—

(3028626) Oxygen [Partial pressure] in Capillary blood

2.00

0.98

6.7

3.4

8.33

8.55

kpa

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.00

0.98

1.1

1.4

—

(3012516) Albumin [Mass/volume] in Urine

320

1.41

0.98

4.9

3.3

2275.82

251.51

mg/l

0.65

213

(3022621) pH of Urine by Test strip

1.84

0.97

6.5

2.3

—

(3009261) Glucose [Presence] in Urine by Test strip

529

1.36

0.97

5.2

3.7

0.00

estimate

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

161

1.52

0.95

1.4

1.2

18.40

34.00

iu/ml

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.28

0.95

1.3

2.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.12

0.90

1.2

1.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

243

1.42

0.89

4.3

3.7

—

(3025159) Blasts/100 leukocytes in Blood

1.73

0.88

4.2

4.8

0.00

0.04

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

2.05

0.88

1.2

1.8

1685.50

106.17

e6/l

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

2.05

0.88

1.0

1.7

16.33

2.63

e6/l

—

(3034770) Mitochondria Ab [Titer] in Serum

1.83

0.86

1.3

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.98

0.85

2.0

1.9

—

(3029937) Albumin [Presence] in Urine by Test strip

291

1.38

0.84

5.9

4.0

0.00

0.01

estimate

0.50

(3030467) Casts [#/volume] in Urine by Automated count

319

1.36

0.83

5.1

2.8

0.65

0.41

e6/l

0.28

239

(3004588) Protein electrophoresis panel - Serum or Plasma

1.73

0.81

3.3

1.8

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

252

0.67

0.81

3.3

2.8

0.54

0.77

ug/l

1.83

170

(3045414) Leukocytes [Presence] in Urine

1.86

0.80

1.7

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

1045

0.73

0.78

5.7

4.5

6.43

6.02

mmol/l

1.03

952

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.75

0.78

3.9

3.1

0.72

0.71

—

(3009508) Creatinine [Moles/volume] in Urine

341

1.34

0.78

4.8

3.1

6.86

7.77

mmol/l

0.85

284

(3005322) IgE [Units/volume] in Serum or Plasma

1.75

0.77

2.1

1.1

169.33

234.83

u/ml

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.22

0.77

3.6

3.2

—

1127.40

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.68

0.75

1.1

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.67

0.74

1.9

1.4

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

2.04

0.73

2.8

1.3

14.38

6.28

u/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

526

1.29

0.73

6.5

4.9

0.00

estimate

0.00

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.65

0.71

12.5

7.6

23.73

24.46

mmol/l

0.22

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

354

0.74

0.70

5.0

4.4

17.84

20.98

0.63

179

(3035350) Ketones [Presence] in Urine by Test strip

519

1.28

0.70

5.4

3.7

0.00

estimate

0.00

100

(3044290) Cell count panel - Cerebral spinal fluid

1.88

0.69

1.0

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

104

1.50

0.66

1.5

1.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

192

1.37

0.65

4.2

2.7

0.41

0.98

e6/l

1.31

113

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

101

0.58

0.65

2.7

1.8

—

(4035726)

1.51

0.64

1.4

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

341

1.29

0.63

6.0

4.0

3.10

9.68

mg/mmol

1.95

217

(3044889) 12 lead EKG panel

734

1.26

0.62

5.7

4.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

111

1163

0.72

0.62

18.3

10.2

28.88

27.44

u/l

0.46

111

1121

(3022313) Gas panel - Capillary blood

1.54

0.59

6.4

4.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

223

1.32

0.59

1.5

1.3

0.52

2.22

u/ml

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

107

1119

0.78

0.48

34.8

16.2

4.01

3.97

mmol/l

0.85

107

1085

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.45

0.47

4.6

2.8

855.29

49.45

u/ml

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

105

1098

0.79

0.45

6.1

4.9

2.74

2.71

mmol/l

0.15

1009

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.39

0.45

1.4

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

107

1116

0.79

0.44

34.3

16.1

139.07

139.71

mmol/l

1.64

107

1083

(3008898) HLA-B27 [Presence]

1.64

0.43

1.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.44

0.40

9.6

10.2

95.36

95.02

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

170

1.28

0.40

3.2

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

665

1.18

0.38

3.3

3.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.33

0.38

2.0

1.7

—

(3019150) Specific gravity of Urine by Refractometry

229

1.22

0.36

5.7

4.1

1.02

kg/l

—

(3019060) Gas panel - Arterial blood

1.38

0.33

11.2

4.4

—

(40761536) Microorganisms panel - Urine sediment

1.32

0.31

5.3

3.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

104

1078

0.84

0.31

5.8

4.5

4.63

4.58

mmol/l

0.22

994

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

774

1.15

0.30

5.6

3.6

14.75

14.81

pmol/l

0.07

688

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.24

0.29

3.0

2.1

—

(3013512) EKG study

314

1.16

0.26

5.7

3.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

218

1.18

0.25

5.6

6.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.33

0.23

1.8

1.2

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.20

0.21

1.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

289

1.14

0.21

1.4

1.5

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

1.6

—

13.36

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.9

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

111

1081

1.16

0.21

28.6

14.1

23.98

23.07

mg/l

0.10

826

(4146454)

0.00

0.21

0.0

3.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3022145) Colonoscopy Study observation

109

1.21

0.19

1.6

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

131

0.83

0.18

3.5

7.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

988

0.90

0.17

34.9

14.7

39.78

39.95

0.11

709

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

1006

0.90

0.16

23.4

12.8

78.00

80.73

ml/min/173m2

0.52

821

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.13

0.15

2.2

1.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.10

0.15

2.1

1.7

—

(40761511) CBC panel - Blood by Automated count

112

1141

0.88

0.15

25.8

13.0

—

(3000492) Spirometry study

1.19

0.13

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

105

1070

0.91

0.12

5.7

4.5

1.43

1.44

mmol/l

0.06

980

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

105

1.16

0.11

1.4

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

137

1.11

0.08

1.7

1.4

—

(4010399)

0.86

0.07

1.3

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

293

0.94

0.06

6.1

3.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

417

1.05

0.05

5.6

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

103

1039

0.96

0.02

5.0

4.0

1.35

1.30

mmol/l

0.40

946

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

965

0.98

0.00

6.6

4.2

1.96

mu/l

0.02

866

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.3

—

118.30

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.21

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

6.13

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.7

—

(3020393) Adenovirus Ag [Presence] in Stool

0.00

0.0

1.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.90

0.00

1.8

1.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

2.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.5

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.7

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

20.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.2

—

(37020300) Entamoeba histolytica DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.1

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.9

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.9

—

15.79

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

1.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.98

0.00

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.7

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.94

0.00

2.4

1.4

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

27.80

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.4

—

217.20

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.7

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint K11_PERIODONTAL_NOS and mortality.

Females

Parameter	HR [95% CI]	p-value
K11_PERIODONTAL_NOS	1.776 [1.09, 2.88]	0.02
Birth year	0.995 [0.99, 1.0]	0.252

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 350 females with K11_PERIODONTAL_NOS died.

Males

Parameter	HR [95% CI]	p-value
K11_PERIODONTAL_NOS	2.488 [1.67, 3.72]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.025

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 352 males with K11_PERIODONTAL_NOS died.

Mortality risk

Mortality risk for people of age

years, who have K11_PERIODONTAL_NOS.

N-year risk	Females	Males
1	0.191%	0.469%
5	0.983%	2.888%
10	2.583%	7.357%
15	5.177%	13.92%
20	9.002%	22.794%

Relationships between endpoints

↥

Index endpoint: K11_PERIODONTAL_NOS – Periodontal disease, other/unspecified

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Periodontal disease, other/unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints