No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2269 |
4. Check minimum number of eventsNone |
2269 |
5. Include endpointsNone |
2269 |
6. Filter based on genotype QC (FinnGen only) |
1995 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Embolic stroke
based on the number of shared cases.
Similar with more cases:
- Ischaemic Stroke, excluding all haemorrhages
- Stroke, excluding SAH
- Stroke, including SAH
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 28696 | 13054 | 14985 |
| Only index persons | 13155 | 5750 | 7405 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.37 | 0.42 |
| Only index persons | 0.25 | 0.21 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 72.78 | 75.89 | 70.17 |
| Only index persons | 71.63 | 74.92 | 69.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1995 | 674 | 1321 |
| Unadjusted period prevalence (%) | 0.48 | 0.24 | 0.61 |
| Median age at first event (years) | 70.95 | 71.56 | 70.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2049
- Matched controls
- 20470
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint I9_STR_EMBOLIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STR_EMBOLIC | 2.405 [2.14, 2.7] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.196 |
During the follow-up period (1.1.1998 — 31.12.2019), 2865 out of 4903 females with I9_STR_EMBOLIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STR_EMBOLIC | 1.916 [1.72, 2.13] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3377 out of 6534 males with I9_STR_EMBOLIC died.
Mortality risk
Mortality risk for people of age
years, who have I9_STR_EMBOLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.377% |
| 5 | 1.3% | 1.977% |
| 10 | 3.466% | 4.817% |
| 15 | 6.705% | 9.438% |
| 20 | 11.651% | 15.913% |
Relationships between endpoints
↥Index endpoint: I9_STR_EMBOLIC – Embolic stroke
GWS hits: 1