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Aggressive periodontitis

EFO Endpoint Browser PheWeb

K11_PERIODONTOSIS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K05.4
  • Hospital discharge: ICD-10 — K05.4
  • Hospital discharge: ICD-9 — 5235
  • Hospital discharge: ICD-8 — 5235
  • Cause of death: ICD-10 — K05.4
  • Cause of death: ICD-9 — 5235
  • Cause of death: ICD-8 — 5235

3 out of 7 registries used, show all original rules.

783

4. Check minimum number of events

None

783

5. Include endpoints

None

783

6. Filter based on genotype QC (FinnGen only)

730

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 730 396 334
Unadjusted period prevalence (%) 0.15 0.14 0.15
Median age at first event (years) 63.22 61.36 65.42

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
783
Matched controls
7830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K05.4
ICD-10 Finland
Periodontosis
+∞
307.7
779
*
K05.31
ICD-10 Finland
Periodontitis pronounced
10.1
217.7
333
536
EBA00
NOMESCO Finland
Extraction of tooth
7.1
154.2
548
1945
SDA
NOMESCO Finland
Treatment of periodontitis and gingival lesions
31.9
106.4
70
24
SDA12
NOMESCO Finland
Treatment of complicated periodontal disease
15.8
94.3
84
59
K05.30
ICD-10 Finland
Periodontitis complex
4.9
89.3
260
720
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
5.1
83.4
619
3342
K05.38
ICD-10 Finland
Other chronic periodontitis
9.9
79.9
97
110
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.1
79.0
499
2369
WX110
NOMESCO Finland
Infiltration anesthesia
7.8
74.3
716
4529
SDA02
NOMESCO Finland
Periodontal treatment, brief
3.8
73.5
436
1958
SAA02
NOMESCO Finland
Basic examination of mouth
5.6
73.1
673
4072
SAA01
NOMESCO Finland
Simple examination of mouth
7.9
72.9
719
4595
KMAK, ,
NOMESCO Finland
4.1
70.9
565
3053
SDA03
NOMESCO Finland
Periodontal treatment
3.7
70.6
473
2280
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
5.1
69.7
175
422
SDA04
NOMESCO Finland
Demanding periodontal treatment
3.7
69.1
355
1439
SDA10
NOMESCO Finland
Periodontal treatment of complicated disease
22.7
63.4
47
22
K05.3
ICD-10 Finland
Chronic periodontitis
6.4
61.7
112
200
K04.5
ICD-10 Finland
Chronic apical periodontitis
3.4
61.1
350
1496
SBA00
NOMESCO Finland
Microbiological examinations
10.4
59.1
68
71
D19
ICPC
Teeth/gum symptom/complaint
3.3
58.0
339
1458
SAA03
NOMESCO Finland
Extended examination of mouth
3.2
56.8
434
2178
K02.1
ICD-10 Finland
Caries of dentine
3.6
54.6
587
3567
SAA04
NOMESCO Finland
Special examination of mouth
6.0
53.6
102
190
Z01.2
ICD-10 Finland
Dental examination
3.1
53.2
471
2541
EMAK, ,
NOMESCO Finland
6.8
52.1
87
142
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
3.1
51.9
493
2754
SFA10
NOMESCO Finland
One-surface restoration
3.3
50.9
550
3289
WX290
NOMESCO Finland
Other blockage of nerve
3.1
50.2
482
2689
SDA05
NOMESCO Finland
Very demanding periodontal treatment
5.1
49.6
115
256
SDA13
NOMESCO Finland
Treatment of complicated periodontal disease, extensive and demanding
57.9
42.0
49
9
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.6
41.3
165
547
SFA20
NOMESCO Finland
Two-surface restoration
2.9
40.7
560
3616
SDC30
NOMESCO Finland
Reinforced periodontal fixation, simple
14.5
39.3
36
26
SCA01
NOMESCO Finland
Preventive oral health care, short
2.7
37.5
292
1406
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.6
36.7
312
1566
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
2.7
34.5
272
1308
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.3
33.0
70
143
VALMI, ,
NOMESCO Finland
2.6
31.1
249
1197
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.5
29.9
251
1231
SPA02
NOMESCO Finland
Preparation for dental prosthetics
5.6
29.8
59
113
WZC00
NOMESCO Finland
Treatment plan or consultation
2.3
29.0
343
1954
-1, ,
NOMESCO Finland
2.4
28.9
318
1757
A29
ICPC
General symptom/complaint other
2.9
27.6
150
588
SFA30
NOMESCO Finland
Three-surface restoration
2.2
26.5
409
2576
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
2.2
25.4
411
2622
K02.2
ICD-10 Finland
Caries of cementum
4.1
25.3
73
191
SDA01
NOMESCO Finland
Periodontal treatment, very brief
2.3
24.7
258
1376
K05.39
ICD-10 Finland
Periodontitis UNS
6.7
24.1
39
61
SPA47
NOMESCO Finland
Precision impression for denture
5.4
24.1
49
96
SDE04
NOMESCO Finland
Periodontal treatment by dental hygienist, very extensive
3.0
23.7
117
433
EAV, ,
NOMESCO Finland
6.8
23.2
37
57
SPE01
NOMESCO Finland
Mucosa-supported partial denture
6.2
23.1
40
67
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
3.5
22.8
85
265
SDA11
NOMESCO Finland
Periodontal treatment, complicated disease – extensive and demanding
123.6
22.7
24
*
K05.28
ICD-10 Finland
Another acute periodontitis
8.0
22.7
31
40
SDC10
NOMESCO Finland
Periodontal fixation, simple
8.0
22.7
31
40
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.2
21.0
218
1147
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.0
18.5
399
2719
SCA02
NOMESCO Finland
Preventive oral health care
2.8
18.3
99
383
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
5.0
18.0
39
81
K05.20
ICD-10 Finland
Periodontal abscess without fistula
6.7
17.6
28
43
EB1VA, ,
NOMESCO Finland
2.4
16.8
128
586
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
2.0
16.2
245
1466
K04.4
ICD-10 Finland
Acute apical periodontitis of pulpal origin
2.6
16.2
101
420
TUPKY, ,
NOMESCO Finland
12.6
15.9
28
23
D82
ICPC
Teeth/gum disease
1.9
15.9
307
1991
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
2.1
15.4
190
1054
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.9
15.3
78
292
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
15.2
207
1191
SGB10
NOMESCO Finland
Root filling of tooth with one root canal
2.3
15.0
122
573
SAE02, ,
NOMESCO Finland
13.5
14.8
25
19
S21
ICPC
Skin texture symptom/complaint
2.2
14.6
132
648
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
14.5
164
880
SPA51
NOMESCO Finland
Determination of bite and dental arch location, demanding
12.9
14.5
25
20
SGA02
NOMESCO Finland
Opening and preparing the root canals
2.2
14.3
130
639
SPE02
NOMESCO Finland
Metal-framed partial denture
5.4
14.3
28
53
SPF02
NOMESCO Finland
Impression for dental prosthesis repair, restricted
6.8
14.1
22
33
S29
ICPC
Skin symptom/complaint other
2.0
13.7
164
897
N07BA03
ATC
varenicline; oral
3.1
13.6
57
191
SFA00
NOMESCO Finland
Small restoration
2.2
13.4
126
627
EBA30
NOMESCO Finland
Extraction of root of tooth
2.9
13.2
66
244
-69
ICPC
Other reason for encounter NEC
3.5
13.1
45
133
L29
ICPC
Musculoskeletal sympt/complt other
2.6
13.0
81
336
EBA10
NOMESCO Finland
Operative extraction of tooth
2.4
12.8
99
453
SBB10
NOMESCO Finland
Dental impressions
2.9
12.7
62
226
K04.1
ICD-10 Finland
Necrosis of pulp
2.3
12.6
104
490
ECA50
NOMESCO Finland
Periodontal flap surgery
9.5
12.5
25
27
ECB00
NOMESCO Finland
Suture of gingiva
3.6
12.4
42
123
-60
ICPC
Result test/procedure
2.9
12.3
60
219
SPE90
NOMESCO Finland
Other partial denture
4.5
12.0
29
66
F16
ICPC
Eyelid symptom/complaint
3.0
11.8
52
179
TUPEI, ,
NOMESCO Finland
3.5
11.8
40
117
K08.3
ICD-10 Finland
Retained dental root
2.5
11.8
74
308
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.1
11.7
49
164
K05.21
ICD-10 Finland
Periodontal abscess with fistula
9.1
11.3
23
26
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
3.0
11.1
49
169
SPE00
NOMESCO Finland
Partial denture with metal framework
5.1
11.0
23
46
K05
ICD-10 Finland
Gingivitis and periodontal diseases
5.1
11.0
23
46
SPA50
NOMESCO Finland
Determination of bite and dental arch location
4.7
10.8
25
55
ZYD01, ,
SPAT
14.4
10.5
17
12
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
5.5
10.4
20
37
K25
ICPC
Fear of hypertension
3.1
10.2
42
139
SDC40
NOMESCO Finland
Reinforced periodontal fixation, extensive
13.3
10.2
17
13
SGA01
NOMESCO Finland
Emergency treatment
1.9
10.2
135
760
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.6
10.0
33
95
SGA03
NOMESCO Finland
Opening and preparing the root canals, complicated
2.2
9.6
85
412
N02BE01
ATC
paracetamol; systemic, rectal
2.1
9.4
701
6286
S02.5
ICD-10 Finland
Fracture of tooth
3.4
9.4
34
104
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.5
9.3
31
90
R05
ICPC
Cough
1.7
9.2
191
1232
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
4.5
9.1
22
50
S02.51
ICD-10 Finland
Fracture of tooth, open
2.1
9.1
92
470
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
8.9
98
516
SAAPA, ,
NOMESCO Finland
6.9
8.9
21
31
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.6
8.8
50
198
SPF40
NOMESCO Finland
Removal and reattachment of crown or small bridge
4.8
8.6
19
40
K05.19
ICD-10 Finland
Gingivitis (chronic) ulcerative
3.4
8.6
31
95
SXA20
NOMESCO Finland
Local application of medicine to mouth
2.6
8.5
51
208
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.7
8.5
184
1198
SDA14
NOMESCO Finland
Treatment of complicated periodontal disease, extensive and very demanding
91.0
8.4
9
*
L03
ICPC
Low back symptom/complaint
1.7
8.4
210
1418
SPA60
NOMESCO Finland
Fitting of intermediary dental prosthesis structures, 1 to 3 units
4.5
8.4
20
45
P17
ICPC
Tobacco abuse
5.0
8.4
18
37
K85
ICPC
Elevated blood pressure
1.8
8.4
134
799
L17
ICPC
Foot/toe symptom/complaint
1.6
8.2
223
1539
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
8.1
202
1361
Z72.0
ICD-10 Finland
Tobacco use
3.4
8.0
28
84
SGC00
NOMESCO Finland
Medication, disinfection of root canals
2.0
7.9
90
480
XA402
NOMESCO Finland
ENMG
3.3
7.9
29
90
WYA10
NOMESCO Finland
Emergency care or similar visit
2.3
7.9
63
293
S04
ICPC
Lump/swelling localized
2.0
7.7
81
420
WZC00, ,
SPAT
2.1
7.7
79
406
A04
ICPC
Weakness/tiredness general
1.9
7.6
104
589
Z2221, ,
SPAT
25.3
7.6
10
*
K04.09
ICD-10 Finland
Pulpit UNS
2.6
7.5
43
171
P25
ICPC
Phase of life problem adult
2.9
7.5
34
120
K02.8
ICD-10 Finland
Other dental caries
3.3
7.5
28
88
K84
ICPC
Heart disease other
3.5
7.3
25
74
P01
ICPC
Feeling anxious/nervous/tense
2.0
7.2
75
386
P15
ICPC
Chronic alcohol abuse
3.0
7.2
32
111
A01
ICPC
Pain general/multiple sites
2.0
7.2
75
387
P01AB01
ATC
metronidazole; oral, rectal
1.5
7.2
308
2343
SDD01
NOMESCO Finland
Treatment of periodontal bite, restricted
8.0
7.1
15
19
SXC05
NOMESCO Finland
Other oral or dental procedure
2.4
7.1
49
214
ECA55
NOMESCO Finland
Complicated periodontal flap surgery
10.1
7.0
13
13
H29
ICPC
Ear symptom/complaint other
1.9
6.9
87
479
K29
ICPC
Cardiovascular sympt/complt other
2.7
6.9
36
137
K00.09
ICD-10 Finland
Lack of teeth due to lack of dental development UNS
4.2
6.8
18
44
S18
ICPC
Laceration/cut
1.5
6.8
348
2735
WZA00
NOMESCO Finland
Concise certificate
2.3
6.8
50
225
L08
ICPC
Shoulder symptom/complaint
1.6
6.7
166
1111
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.8
6.7
20
54
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.0
6.6
29
100
H13
ICPC
Plugged feeling ear
1.7
6.6
141
909
HMAK, ,
NOMESCO Finland
1.8
6.5
92
526
L28
ICPC
Limited function/disability (L)
1.7
6.5
124
777
T90
ICPC
Diabetes non-insulin dependent
1.6
6.4
185
1284
SPF12
NOMESCO Finland
Fitting of the denture in the mouth during the repair of the loose prosthesis
6.0
6.3
16
27
SPA48
NOMESCO Finland
Precision impression for denture, demanding
9.4
6.3
12
13
R02
ICPC
Shortness of breath/dyspnoea
1.8
6.3
97
571
N17
ICPC
Vertigo/dizziness
1.9
6.2
85
481
K08
ICD-10 Finland
Other disorders of teeth and supporting structures
26.9
6.2
8
*
SPC35
NOMESCO Finland
Production and attachment of fibre-reinforced dental bridge
4.0
6.2
17
43
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
6.2
214
1546
SGB20
NOMESCO Finland
Root filling of tooth with onetwo root canals
2.2
6.2
53
254
K86
ICPC
Hypertension uncomplicated
1.8
6.1
98
583
A97
ICPC
No disease
1.7
6.1
129
829
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
1.6
6.1
187
1315

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
589
4692
2.03
16.14
3.8
3.7
—
—
—
0
0
672
5693
2.27
14.64
19.9
16.6
14.73
15.02
%
0.74
656
5595
749
6795
3.36
11.98
18.9
16.0
139.69
139.71
mmol/l
0.08
735
6626
750
6820
3.37
11.73
19.1
16.1
3.99
3.97
mmol/l
1.02
735
6642
244
1602
1.76
11.32
7.0
7.0
—
—
—
0
0
271
1870
1.69
10.33
4.9
4.2
7.39
7.40
ph
0.84
61
361
247
1666
1.70
10.23
4.3
3.8
90.97
91.76
%
0.18
240
1622
380
2865
1.63
10.20
10.6
9.5
0.00
0.00
e9/l
0.09
317
2354
715
6443
2.26
9.75
5.0
4.6
6.10
5.96
mmol/l
1.48
664
5911
473
3831
1.59
8.94
5.6
4.8
6.80
6.70
mmol/l
0.40
449
3585
248
1744
1.62
8.45
3.2
3.0
—
—
—
0
0
386
3021
1.55
8.20
16.5
13.1
1.25
1.23
inr
0.20
134
882
127
753
1.82
8.06
4.2
2.7
7.82
8.72
umol/l
0.22
108
657
251
1790
1.59
7.99
3.3
3.1
0.34
0.48
e6/l
0.85
202
1360
769
7280
4.15
7.60
24.1
20.5
250.71
249.52
e9/l
0.18
753
7105
769
7280
4.15
7.60
24.4
20.6
40.01
40.34
%
0.61
706
6818
769
7283
4.13
7.53
24.0
20.5
91.44
91.13
fl
1.01
758
7181
769
7283
4.13
7.53
23.9
20.4
30.35
30.36
pg
0.02
758
7181
769
7283
4.13
7.53
24.0
20.6
6.91
6.69
e9/l
2.01
750
7086
769
7284
4.12
7.51
24.0
20.5
4.50
4.51
e12/l
0.06
752
7091
769
7286
4.10
7.46
24.1
20.7
135.30
135.99
g/l
0.65
756
7183
750
7013
2.65
7.42
12.3
10.6
25.87
26.69
u/l
0.73
721
6778
736
6851
2.24
6.93
14.6
13.2
—
—
—
0
0
379
3027
1.49
6.89
6.1
6.0
2.98
2.92
%
0.22
359
2843
353
2780
1.49
6.87
6.0
5.0
35.56
35.57
g/l
0.01
323
2608
713
6571
1.95
6.75
4.9
4.5
4.63
4.69
mmol/l
0.90
665
6122
40
163
2.53
6.70
2.7
2.4
—
—
—
0
0
94
537
1.85
6.70
5.0
3.8
—
—
—
0
0
379
3042
1.48
6.63
6.5
6.3
8.61
8.60
%
0.02
360
2864
385
3101
1.48
6.61
6.3
6.1
28.20
27.78
%
0.31
366
2925
263
1968
1.51
6.48
3.3
3.2
34.28
88.33
e6/l
0.88
207
1525
663
6000
1.69
6.43
4.9
4.6
1.87
2.10
mu/l
0.57
620
5494
380
3064
1.47
6.43
5.9
5.9
56.27
57.12
%
0.74
360
2889
579
5088
1.53
6.25
9.2
7.7
81.13
78.38
u/l
0.57
546
4774
35
140
2.57
6.10
2.8
2.8
—
—
—
0
0
89
517
1.81
6.01
4.4
3.8
1.22
1.23
mmol/l
0.60
74
450
328
2597
1.45
5.96
2.0
1.9
96.47
95.78
pmol/l
0.10
182
1344
155
1052
1.59
5.87
3.2
3.5
0.80
0.82
mmol/l
1.05
145
991
201
1461
1.51
5.57
3.6
3.6
—
—
—
0
0
55
279
2.04
5.55
4.5
3.8
23.56
24.25
mmol/l
0.69
55
273
717
6690
1.85
5.50
5.2
5.0
2.77
2.78
mmol/l
0.08
673
6195
704
6535
1.77
5.48
4.7
4.5
1.40
1.47
mmol/l
4.61
661
6058
384
3167
1.42
5.42
7.8
7.1
1.21
1.21
mmol/l
0.19
320
2716
279
2173
1.44
5.41
4.3
3.3
30.45
32.35
u/l
0.51
265
2065
359
2927
1.42
5.40
6.2
6.0
0.68
0.68
%
0.01
340
2742
149
1035
1.54
5.06
2.9
2.9
2.09
2.10
e6/l
0.01
92
571
49
247
2.05
5.05
1.0
1.0
—
—
—
0
0
155
1092
1.52
4.93
3.0
2.7
0.65
0.95
e6/l
1.35
100
624
393
3290
1.39
4.91
6.1
5.9
1.95
2.00
e9/l
0.18
350
2929
547
4850
1.42
4.82
4.1
4.1
13.66
11.87
mm/h
1.96
515
4494
168
1209
1.50
4.82
3.3
3.9
237.47
397.81
ng/l
0.52
134
950
128
870
1.56
4.78
2.7
2.5
22.23
23.56
%
0.42
114
749
71
415
1.78
4.72
2.5
2.5
—
—
—
0
0
349
2879
1.38
4.69
7.2
6.3
1.21
1.21
mmol/l
0.28
322
2639
32
140
2.34
4.67
3.1
3.6
3.25
2.55
mmol/l
0.53
17
93
509
4477
1.39
4.56
5.1
4.2
—
—
—
0
0
384
3229
1.37
4.54
6.0
5.9
0.04
0.04
e9/l
0.51
332
2817
700
6548
1.65
4.51
17.3
14.0
21.84
23.88
mg/l
0.87
567
5150
101
658
1.61
4.51
1.4
1.4
—
—
—
0
0
382
3219
1.36
4.41
6.0
5.9
0.61
0.58
e9/l
1.20
331
2803
679
6317
1.56
4.35
4.3
4.0
1.39
1.30
mmol/l
1.76
635
5823
53
292
1.87
4.27
2.2
1.7
—
—
—
0
0
557
5003
1.39
4.20
4.1
3.9
14.60
14.78
pmol/l
1.02
513
4560
432
3729
1.35
4.18
10.2
9.3
4.12
4.07
e9/l
0.19
379
3273
241
1899
1.39
4.17
3.2
2.9
—
—
—
0
0
391
3327
1.35
4.15
6.3
6.1
0.20
0.19
e9/l
0.11
344
2948
55
310
1.83
4.14
2.7
3.3
—
—
—
0
0
37
182
2.08
4.11
2.6
3.1
1.48
1.53
mg/l
0.17
32
168
139
993
1.49
4.10
2.7
2.4
12.32
13.32
umol/l
0.87
132
926
664
6173
1.50
3.99
6.3
5.7
40.09
39.83
mmol/mol
0.32
620
5742
373
3165
1.34
3.97
3.9
3.5
0.00
0.00
estimate
0.50
94
634
248
1985
1.36
3.85
2.4
2.1
157.45
239.57
u/l
1.15
229
1871
373
3175
1.33
3.85
5.2
4.7
0.00
0.00
estimate
-0.00
89
600
278
2267
1.35
3.82
4.0
3.7
107.48
94.67
e6/l
0.13
221
1628
224
1771
1.37
3.74
1.5
1.4
—
—
—
0
0
399
3441
1.33
3.71
7.3
6.5
10.84
11.43
umol/l
0.48
372
3266
136
987
1.46
3.70
2.2
2.0
—
—
—
0
0
374
3211
1.32
3.53
3.9
3.5
0.00
0.01
estimate
0.80
87
576
16
390
0.40
3.51
1.5
1.5
—
—
—
0
0
127
919
1.46
3.50
2.7
2.4
2.24
2.33
g/l
1.13
122
851
255
2075
1.34
3.50
4.1
3.8
19.20
8.78
mg/mmol
1.03
162
1303
8
14
5.76
3.34
1.1
1.1
—
—
—
0
0
220
1764
1.34
3.31
4.2
4.3
—
—
—
0
0
176
1372
1.36
3.16
2.6
2.6
5.93
4.92
e6/l
0.63
158
1240
76
511
1.54
3.00
11.8
9.2
—
—
—
0
0
19
81
2.38
3.00
1.7
1.4
—
—
—
0
0
71
471
1.56
2.98
1.1
1.1
—
—
—
0
0
187
1487
1.34
2.94
1.6
1.5
18.46
20.85
nmol/l
1.35
173
1254
9
22
4.13
2.89
3.6
6.3
—
—
—
0
0
249
2070
1.30
2.84
3.4
3.1
7.36
7.63
mmol/l
0.41
212
1752
81
561
1.50
2.80
3.9
3.6
5.92
5.84
kpa
0.23
81
546
81
561
1.50
2.80
3.9
3.6
1.30
2.11
mmol/l
0.84
73
455
312
2674
1.28
2.79
2.4
2.3
73.67
76.73
nmol/l
1.10
280
2386
9
23
3.95
2.78
1.2
1.4
—
—
—
0
0
131
996
1.38
2.74
1.7
1.8
—
—
—
0
0
159
1252
1.34
2.66
1.6
1.4
2.51
2.51
g/l
0.00
83
778
26
134
1.97
2.63
2.9
2.5
17.71
16.24
%
0.70
14
70
80
561
1.47
2.61
9.3
7.5
1.39
1.36
mmol/l
0.11
80
551
235
1959
1.29
2.59
3.8
3.3
638.05
291.46
mg/l
0.41
155
1264
164
1303
1.33
2.58
2.6
2.8
555.13
550.39
mosm/kgh2o
0.09
142
1120
224
1872
1.28
2.40
1.8
1.7
1.61
1.41
mmol/l
1.92
189
1584
245
2070
1.27
2.40
2.5
2.6
57.22
59.83
u/l
0.36
224
1921
255
2166
1.26
2.39
3.5
3.6
2.34
2.35
mmol/l
0.62
238
1928
84
606
1.43
2.38
2.8
2.4
52.48
38.83
u/l
0.30
71
521
346
3044
1.24
2.38
6.9
6.4
—
—
—
0
0
85
615
1.43
2.38
2.0
2.2
0.22
0.21
g/l
0.54
72
573
65
448
1.49
2.33
1.4
1.4
—
—
—
0
0
62
425
1.50
2.29
2.2
1.6
1.45
1.36
g/l
0.06
56
393
6
13
4.64
2.27
1.2
1.9
12.42
17.75
umol/l
—
6
13
6
13
4.64
2.27
1.2
1.2
—
—
—
0
0
71
505
1.45
2.19
3.8
4.2
0.95
0.57
%
0.92
31
174
188
1554
1.28
2.18
2.2
2.0
2.75
3.09
mg/l
1.07
171
1325
69
490
1.45
2.15
3.8
4.4
2.69
0.06
%
0.56
29
144
40
613
0.63
2.12
1.3
1.4
—
—
—
0
0
8
25
3.22
2.10
1.0
1.1
—
—
—
0
0
111
859
1.34
2.09
7.1
6.0
1.09
1.03
mmol/l
1.14
104
796
17
82
2.10
2.08
2.0
2.7
—
—
—
0
0
0
57
0.00
2.06
0.0
1.1
—
—
—
0
0
20
104
1.95
2.02
2.0
2.1
69.23
61.24
%
0.88
20
104
8
26
3.10
2.01
1.0
1.0
—
—
—
0
0
141
1137
1.29
1.99
1.9
1.7
1101.47
1211.11
nmol/l
0.76
112
868
44
648
0.66
1.95
6.2
4.5
—
—
—
0
0
62
440
1.44
1.95
3.6
2.9
3.68
7.09
e9/l
1.47
54
365
24
136
1.79
1.89
2.1
2.3
11553.47
5023.50
u/l
—
6
53
18
328
0.54
1.87
1.7
1.7
—
—
—
0
0
32
198
1.64
1.86
3.5
2.8
—
—
—
0
0
92
706
1.34
1.85
1.7
1.6
—
—
—
0
0
20
108
1.87
1.83
1.1
1.1
15123.74
148.03
iu/ml
—
5
25
217
1860
1.23
1.82
2.8
3.1
1735.11
1175.86
ng/l
0.84
186
1589
9
35
2.59
1.80
2.2
1.6
1.89
2.31
u/field
—
9
29
28
169
1.68
1.79
1.6
1.3
—
—
—
0
0
97
755
1.33
1.77
1.7
1.6
—
—
—
0
0
28
170
1.67
1.76
1.6
1.3
—
—
—
0
0
28
170
1.67
1.76
1.6
1.3
—
—
—
0
0
26
155
1.70
1.74
1.6
1.3
—
—
—
0
0
175
1474
1.24
1.72
1.7
1.7
1.50
1.17
mg/l
0.35
130
1131
106
845
1.29
1.64
1.7
1.6
—
—
—
0
0
28
174
1.63
1.63
1.1
1.1
—
—
—
0
0
5
14
3.59
1.61
1.2
1.1
—
—
—
0
0
21
121
1.76
1.59
1.6
2.9
—
—
—
0
0
25
152
1.67
1.58
1.2
1.2
—
—
—
0
0
27
169
1.62
1.54
1.6
1.3
—
—
—
0
0
6
140
0.42
1.53
1.2
1.7
—
—
—
0
0
30
193
1.58
1.53
1.3
1.2
—
1586.67
—
0
6
163
1382
1.23
1.50
1.2
1.2
3.39
1.52
u/ml
0.35
33
387
72
551
1.34
1.50
4.1
4.3
1.29
0.96
%
0.53
31
204
103
829
1.28
1.49
1.4
1.4
—
—
—
0
0
20
117
1.73
1.46
2.4
1.5
—
—
—
0
0
7
28
2.51
1.45
1.7
3.5
—
—
—
0
0
68
522
1.33
1.40
4.2
4.4
0.07
0.11
%
0.30
28
174
9
40
2.26
1.40
1.2
1.5
—
—
—
0
0
9
40
2.26
1.40
2.2
1.6
90.67
76.12
umol/l
—
9
40
281
2522
1.18
1.40
3.8
3.5
30.29
41.67
ng/l
1.17
189
1766
20
119
1.70
1.39
1.4
1.5
—
—
—
0
0
468
4379
1.17
1.37
3.7
3.2
47.17
52.07
u/l
0.74
438
4090
29
191
1.54
1.36
2.2
1.6
283.79
281.26
mu/l
0.02
24
171
282
2542
1.17
1.32
3.4
3.3
5.81
5.84
ph
0.05
13
203
17
98
1.75
1.32
1.2
1.2
2.63
6.93
u/ml
—
8
42
20
121
1.67
1.31
4.0
3.3
4.07
4.50
e9/l
0.50
20
121
141
1195
1.22
1.31
2.6
3.1
2.46
2.45
mmol/l
0.79
119
1060
198
1734
1.19
1.31
3.2
2.7
2823.75
6232.91
umol/l
0.94
177
1522
20
122
1.66
1.28
2.8
2.6
—
—
—
0
0
298
2706
1.16
1.26
3.0
2.7
142.04
136.36
ug/l
0.16
277
2502
160
1379
1.20
1.26
1.7
1.7
440.79
19688199.48
pmol/l
1.29
126
1153
12
63
1.92
1.23
1.2
1.1
—
—
—
0
0
5
19
2.64
1.21
1.0
1.5
—
—
—
0
0
21
323
0.64
1.21
3.8
3.6
—
—
—
0
0
37
264
1.42
1.21
2.3
2.5
—
—
—
0
0
34
472
0.71
1.18
1.2
1.4
—
—
—
0
0
14
79
1.79
1.17
1.6
1.2
—
—
—
0
0
338
3113
1.15
1.16
2.9
2.5
—
—
—
0
0
12
210
0.56
1.16
23.7
9.6
—
—
—
0
0
161
1400
1.19
1.15
3.3
3.8
1.02
1.02
kg/l
0.35
66
201
20
126
1.60
1.15
4.2
3.7
58.20
58.08
%
0.02
20
126
109
913
1.23
1.15
1.2
1.2
—
—
—
0
0
64
504
1.29
1.14
3.3
3.0
67.41
72.04
e9/l
0.44
47
395
17
103
1.66
1.13
1.4
1.4
—
—
—
0
0
33
234
1.43
1.12
1.5
2.3
231.17
470.50
ug/l
0.63
33
220
85
695
1.25
1.12
2.8
2.9
1.63
1.79
%
1.14
80
626
5
21
2.39
1.09
1.6
1.6
—
—
—
0
0
8
41
1.96
1.09
2.0
3.7
—
—
—
0
0
41
544
0.74
1.09
2.7
3.3
—
—
—
0
0
7
32
2.20
1.08
1.0
1.3
—
—
—
0
0
89
736
1.24
1.07
9.4
8.3
5.05
5.13
kpa
0.30
84
710
89
736
1.24
1.07
9.4
8.3
11.98
12.08
kpa
0.08
83
713
17
105
1.63
1.06
1.1
1.0
—
—
—
0
0
10
52
1.94
1.06
2.0
2.4
985.80
682.72
ml
—
5
32
288
2637
1.15
1.06
2.0
2.1
—
—
—
0
0
83
682
1.24
1.06
4.3
4.3
4.62
32.71
ug/l
1.53
73
574
41
541
0.74
1.05
1.3
1.3
—
—
—
0
0
5
22
2.28
1.03
2.6
1.5
—
—
—
0
0
30
213
1.42
1.03
2.3
2.7
9.81
10.52
g/l
0.51
30
194
196
1749
1.16
1.03
3.6
3.1
—
—
—
0
0
61
485
1.28
1.02
2.7
3.0
160.03
199.88
ng/l
0.54
56
443
17
107
1.60
1.00
2.0
1.7
—
—
—
0
0
28
198
1.43
0.99
6.9
4.3
63.56
85.05
mg/l
0.26
21
162
9
49
1.85
0.99
2.9
1.3
—
—
—
0
0
11
61
1.81
0.98
1.1
1.4
—
—
—
0
0
35
258
1.37
0.98
3.9
3.5
196.10
5393.42
u/ml
0.75
30
222
25
174
1.45
0.96
1.3
1.3
215.44
214.93
miu/ml
0.00
12
80
250
2283
1.14
0.94
5.4
4.9
2.58
2.38
ug/l
0.22
230
2062
17
110
1.56
0.91
1.2
1.1
—
—
—
0
0
20
135
1.49
0.90
1.8
1.3
—
—
—
0
0
20
135
1.49
0.90
2.2
2.7
—
—
—
0
0
6
29
2.08
0.89
1.2
1.7
—
—
—
0
0
9
152
0.59
0.89
1.6
1.4
1228.89
207.44
pmol/l
—
9
147
8
43
1.87
0.87
7.0
2.8
—
—
—
0
0
12
72
1.68
0.85
1.3
1.7
—
—
—
0
0
16
104
1.55
0.85
3.9
3.6
1.75
1.24
%
0.22
16
99
8
45
1.79
0.84
1.0
1.2
—
—
—
0
0
8
46
1.75
0.82
1.9
3.5
—
—
—
0
0
86
731
1.20
0.82
9.6
8.4
0.24
1.23
mmol/l
1.36
71
592
27
198
1.38
0.81
7.1
4.3
69.68
31.14
mg/l
0.59
21
164
61
505
1.23
0.77
5.7
3.9
104.61
87.51
ng/l
0.64
56
453
13
83
1.58
0.75
1.5
2.4
34.00
32.59
pg
0.37
13
83
12
75
1.61
0.75
1.2
1.3
—
—
—
0
0
5
24
2.09
0.74
1.4
1.0
—
—
—
0
0
53
434
1.24
0.74
3.5
2.7
—
—
—
0
0
189
1724
1.13
0.73
4.4
3.9
0.00
0.01
estimate
0.88
86
588
72
611
1.20
0.72
1.4
1.4
—
—
—
0
0
25
186
1.36
0.70
1.3
2.8
36.11
38.04
g/l
0.68
25
168
21
152
1.39
0.69
8.6
4.6
—
—
—
0
0
7
42
1.67
0.68
1.4
2.2
8.71
10.11
mmol/l
—
7
42
19
136
1.41
0.67
1.3
1.4
—
—
—
0
0
5
28
1.79
0.66
2.4
2.6
39320.00
38928.75
ug/l
—
5
28
11
166
0.66
0.65
4.2
4.1
—
—
—
0
0
43
351
1.24
0.64
14.7
10.9
—
—
—
0
0
60
508
1.20
0.63
2.1
2.2
12.77
13.04
nmol/l
0.08
51
455
11
71
1.56
0.62
3.2
2.5
—
—
—
0
0
127
1143
1.13
0.61
1.3
1.3
21.61
33.25
iu/ml
1.10
56
356
16
113
1.42
0.61
1.1
1.1
—
—
—
0
0
44
365
1.22
0.58
1.3
1.3
—
—
—
0
0
39
320
1.23
0.57
2.0
2.4
—
—
—
0
0
6
36
1.67
0.56
2.8
1.7
—
—
—
0
0
9
61
1.48
0.54
6.3
2.6
—
—
—
0
0
36
296
1.23
0.52
1.9
2.4
1.94
1.20
%
1.46
36
296
18
135
1.34
0.51
1.8
1.3
—
—
—
0
0
34
279
1.23
0.51
1.1
1.2
—
—
—
0
0
9
65
1.39
0.50
2.2
1.9
—
—
—
0
0
19
145
1.32
0.49
3.7
1.8
—
—
—
0
0
51
439
1.17
0.47
1.1
1.2
176.13
149.72
iu/ml
—
8
185
18
137
1.32
0.47
1.2
1.2
273.00
262.31
u/ml
—
10
80
10
68
1.48
0.47
4.1
3.3
50.00
53.59
%
—
10
63
7
48
1.46
0.47
2.3
1.9
46.57
35.66
%
—
7
48
229
2423
0.92
0.46
3.1
2.8
—
—
—
0
0
5
84
0.59
0.45
1.0
1.2
—
—
—
0
0
94
851
1.12
0.44
1.4
1.3
—
—
—
0
0
120
1102
1.11
0.44
1.2
1.3
13.75
11.44
u/ml
0.12
39
429
99
900
1.11
0.43
1.3
1.3
300.95
523.52
titre
1.56
21
193
6
91
0.66
0.42
1.3
1.4
—
—
—
0
0
8
57
1.41
0.42
1.0
1.3
—
—
—
0
0
20
158
1.27
0.42
1.3
1.2
—
—
—
0
0
10
70
1.43
0.42
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
6.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
6.8
—
—
—
0
0
13
171
0.76
0.39
1.0
1.2
497.62
492.80
mg/l
0.01
13
162
7
102
0.68
0.39
1.7
2.6
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
85
772
1.11
0.39
2.3
2.2
152.69
127.24
ug/g
0.37
72
631
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
33.93
—
0
14
20
160
1.26
0.39
1.6
1.7
2.30
5.11
iu/l
—
8
50
83
754
1.11
0.38
1.4
1.7
—
—
—
0
0
32
272
1.18
0.36
1.9
2.2
1.57
1.54
g/l
0.05
27
235
5
78
0.64
0.35
1.2
1.1
—
—
—
0
0
6
42
1.43
0.35
1.7
1.4
—
—
—
0
0
12
91
1.32
0.34
1.1
1.0
0.82
4.36
u/ml
—
5
42
6
90
0.66
0.33
1.3
1.4
—
—
—
0
0
14
110
1.28
0.32
1.1
1.5
—
—
—
0
0
23
193
1.20
0.31
1.7
1.4
322.09
296.76
ug/g
0.22
17
114
7
96
0.73
0.31
1.0
1.1
—
—
—
0
0
10
75
1.34
0.30
2.4
2.4
—
—
—
0
0
13
102
1.28
0.30
1.2
1.7
0.36
0.92
g/l
—
8
79
10
76
1.32
0.28
7.8
4.0
—
—
—
0
0
8
64
1.25
0.27
1.4
1.7
—
—
—
0
0
8
65
1.23
0.27
1.3
1.4
—
—
—
0
0
25
288
0.86
0.26
1.1
1.1
—
166.57
—
0
7
9
72
1.25
0.25
1.1
1.1
—
—
—
0
0
9
73
1.24
0.25
1.3
1.2
—
—
—
0
0
6
85
0.70
0.24
1.5
1.2
0.78
0.62
nmol/l
—
6
78
215
2074
1.05
0.23
2.8
2.4
—
—
—
0
0
5
38
1.32
0.23
1.2
1.0
—
—
—
0
0
7
93
0.75
0.22
1.4
1.5
—
—
—
0
0
7
95
0.73
0.22
1.1
1.2
—
—
—
0
0
7
95
0.73
0.22
1.0
1.1
—
—
—
0
0
19
163
1.17
0.21
1.5
1.3
9.41
9.35
u/l
0.00
14
128
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
81.34
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
57.38
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
27
303
0.89
0.20
2.5
3.4
26.11
25.02
mmol/l
0.98
27
297
47
432
1.09
0.20
1.2
1.2
—
—
—
0
0
6
48
1.25
0.20
3.0
1.7
11.53
10.40
%
—
6
48
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
6
49
1.23
0.20
2.3
1.4
1.00
1.06
g/l
—
6
49
6
50
1.20
0.19
1.0
1.1
330.17
248.11
mg/l
—
6
45
14
164
0.85
0.18
1.4
1.3
—
—
—
0
0
15
174
0.86
0.18
1.3
1.2
—
2.63
—
0
22
40
434
0.92
0.17
3.7
3.5
7.41
7.41
ph
0.09
12
58
22
195
1.13
0.17
1.4
1.2
—
—
—
0
0
7
61
1.15
0.17
1.1
1.2
—
—
—
0
0
10
82
1.22
0.17
2.4
2.4
—
—
—
0
0
8
69
1.16
0.16
1.3
1.1
—
—
—
0
0
11
130
0.84
0.16
1.1
1.2
—
—
—
0
0
22
245
0.90
0.15
3.5
5.1
—
—
—
0
0
6
77
0.78
0.15
1.5
1.2
—
—
—
0
0
6
80
0.75
0.15
1.5
1.2
—
—
nmol/l
—
0
0
9
81
1.11
0.15
1.7
2.7
—
—
—
0
0
9
83
1.09
0.14
1.7
2.6
4.19
4.00
mmol/l
—
9
83
9
83
1.09
0.14
1.7
2.6
105.56
105.43
mmol/l
—
9
83
31
286
1.09
0.13
1.0
1.1
—
—
—
0
0
22
199
1.11
0.13
1.2
1.2
—
—
—
0
0
22
242
0.91
0.13
1.9
3.7
0.54
0.23
g/l
0.72
14
101
139
1350
1.04
0.12
3.1
3.1
0.77
0.76
ug/l
0.08
107
886
157
1608
0.97
0.11
2.9
2.3
—
—
—
0
0
5
47
1.06
0.09
1.2
1.0
208.60
274.59
ng/l
—
5
29
5
48
1.04
0.09
1.2
1.0
796.80
616.73
ng/l
—
5
30
6
54
1.11
0.09
1.2
1.1
54.17
40.60
mg/l
—
6
47
22
205
1.08
0.08
1.5
1.6
0.26
0.23
g/l
1.07
22
195
197
1940
1.02
0.07
3.9
3.7
—
—
—
0
0
8
75
1.07
0.07
1.3
2.2
12.88
13.04
%
—
8
75
8
76
1.05
0.07
1.1
1.4
30.45
30.89
g/l
—
8
66
22
234
0.94
0.06
1.0
1.1
—
—
—
0
0
22
232
0.95
0.05
1.4
1.6
—
—
—
0
0
25
258
0.97
0.02
1.3
1.3
—
1.54
—
0
20
43
422
1.02
0.01
4.0
5.2
—
—
—
0
0
46
452
1.02
0.01
1.4
1.7
—
—
—
0
0
13
126
1.03
0.00
3.0
1.9
5.01
5.13
mmol/24h
0.04
13
109
22
216
1.02
0.00
1.5
1.5
1.20
1.17
g/l
0.18
22
205
18
177
1.02
0.00
2.2
2.4
100.78
99.21
ug/min
—
9
106
12
122
0.98
0.00
1.1
1.4
—
—
—
0
0
76
762
1.00
0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
3.03
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.05
—
0
6
7
71
0.99
-0.00
1.1
1.4
146.29
306.42
pmol/l
—
7
66
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.0
239.40
279.91
mg/l
—
5
47
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: K11_PERIODONTOSIS – Aggressive periodontitis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).