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Idiopathic urticaria

DOID EFO Endpoint Browser PheWeb

L12_URTICA_IDIOPAT

urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L50.1
  • Hospital discharge: ICD-9 — 7081
  • Cause of death: ICD-10 — L50.1
  • Cause of death: ICD-9 — 7081

2 out of 7 registries used, show all original rules.

775

4. Check minimum number of events

None

775

5. Include endpoints

None

775

6. Filter based on genotype QC (FinnGen only)

775

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria idiopathica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5662 3560 2061
Only index persons 5072 3268 1804
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.06
Only index persons 0.10 0.12 0.07
Median age at first event (years)
Whole population 30.93 35.13 23.53
Only index persons 33.36 36.62 27.47

-FinnGen-

Key figures

All Female Male
Number of individuals 775 589 186
Unadjusted period prevalence (%) 0.17 0.20 0.08
Median age at first event (years) 42.54 41.48 45.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
685
Matched controls
6850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.1
ICD-10 Finland
Idiopathic urticaria
4503599627370496.0
323.0
624
*
L50.9
ICD-10 Finland
Urticaria, unspecified
72.1
187.2
211
42
L50.8
ICD-10 Finland
Other urticaria
290.2
121.1
120
5
L50.3
ICD-10 Finland
Dermatographic urticaria
398.4
103.1
101
*
H02AB06
ATC
prednisolone; systemic
5.7
97.2
477
1963
R06AX27
ATC
desloratadine; oral
4.9
80.9
385
1417
C01CA24
ATC
epinephrine; parenteral
9.8
78.2
171
225
L50.0
ICD-10 Finland
Allergic urticaria
36.2
75.2
97
31
R03DC03
ATC
montelukast; oral
5.5
72.5
260
683
R06AE07
ATC
cetirizine; oral
4.2
67.4
460
2245
7081A
ICD-9 Finland
Urticaria, Idiopathic urticaria
+∞
63.5
60
*
XQ800
NOMESCO Finland
Prick test
7.1
62.0
167
297
L50
ICD-10 Finland
Urticaria
31.2
54.8
73
26
R06AE09
ATC
levocetirizine; oral
4.7
53.9
220
631
344
Kela drug reimbursment
Omalizumab
+∞
51.7
49
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.7
49.1
157
340
R03DX05
ATC
omalizumab; parenteral
+∞
46.4
44
*
T78.3
ICD-10 Finland
Angioneurotic oedema
29.5
46.0
62
23
T78.4
ICD-10 Finland
Allergy, unspecified
7.8
45.1
110
164
R06AX22
ATC
ebastine; oral
3.4
33.7
199
744
H02AB07
ATC
prednisone; oral
3.9
31.6
145
439
A02BA02
ATC
ranitidine; systemic
3.0
23.6
154
597
A92
ICPC
Allergy/allergic reaction NOS
7.1
23.6
59
90
R03AC02
ATC
salbutamol; inhalant
2.2
20.8
410
2793
S98
ICPC
Urticaria
17.4
19.3
30
18
L04AD01
ATC
ciclosporin; systemic
9.9
18.1
36
38
H02AB04
ATC
methylprednisolone; systemic
2.7
15.8
115
470
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
15.7
148
697
R06AX13
ATC
loratadine; oral
2.4
15.1
147
705
E0000UV
ATC
NA
2.0
15.1
298
1937
ZX112
NOMESCO Finland
Subcutaneous
7.2
14.6
35
51
R03AK07
ATC
formoterol and budesonide; inhalant
2.2
13.8
154
786
L50.5
ICD-10 Finland
Cholinergic urticaria
76.7
13.6
15
*
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
12.5
13.2
23
19
J01FF01
ATC
clindamycin; systemic
2.1
13.2
189
1072
S88
ICPC
Dermatitis contact/allergic
6.6
13.1
33
52
N02AX02
ATC
tramadol; systemic, rectal
1.9
13.0
260
1675
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
11.9
12.9
23
20
L50.2
ICD-10 Finland
Urticaria due to cold and heat
71.2
12.6
14
*
N05BB01
ATC
hydroxyzine; systemic
3.4
12.5
62
196
D07AB08
ATC
desonide; topical
2.5
11.7
93
398
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
11.7
126
629
XQ802
NOMESCO Finland
Epicutan test
3.6
11.5
52
153
XQ818
NOMESCO Finland
Conjunctival allergen provocation test
+∞
11.5
11
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
11.3
69
251
R03BA02
ATC
budesonide; inhalant
2.1
10.8
136
726
J01AA02
ATC
doxycycline; systemic
1.8
10.7
494
4050
R01AD08
ATC
fluticasone; nasal
1.8
10.7
211
1332
J01FA10
ATC
azithromycin; systemic
1.7
10.5
428
3367
3DX05
NOMESCO Finland
NA
+∞
10.4
10
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
10.3
169
998
S21
ICPC
Skin texture symptom/complaint
2.4
10.0
92
423
J01MA02
ATC
ciprofloxacin; systemic
1.8
9.9
227
1499
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.9
9.8
60
218
A02BC02
ATC
pantoprazole; systemic
1.7
9.7
397
3093
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
9.7
137
765
Z71.8
ICD-10 Finland
Other specified counselling
1.8
9.6
188
1176
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
9.6
174
1061
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
9.6
231
1544
R02
ICPC
Shortness of breath/dyspnoea
2.4
9.5
85
387
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
9.3
247
1696
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
9.1
122
665
R06.0
ICD-10 Finland
Dyspnoea
1.9
9.1
151
894
R06AX26
ATC
fexofenadine; oral
2.7
9.0
63
250
D07AC01
ATC
betamethasone; topical
1.7
8.6
212
1416
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.5
8.6
65
271
D07AA02
ATC
hydrocortisone; topical
2.1
8.6
107
566
P01AB01
ATC
metronidazole; oral, rectal
1.6
8.4
267
1913
L17
ICPC
Foot/toe symptom/complaint
1.8
8.4
163
1010
L20.0
ICD-10 Finland
Besnier prurigo
2.4
8.3
72
324
R51.80
ICD-10 Finland
Headache
1.9
8.2
121
682
R03BA08
ATC
ciclesonide; inhalant
2.5
8.2
66
285
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.7
8.2
34
95
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.1
254
1814
D02AX
ATC
Other emollients and protectives
3.5
8.0
36
107
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.8
7.9
169
1079
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.1
7.8
41
137
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
7.8
187
1232
R01AD09
ATC
mometasone; nasal
1.6
7.7
313
2377
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
7.7
72
334
D07AC13
ATC
mometasone; topical
1.7
7.6
184
1217
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
7.5
168
1088
XQ817
NOMESCO Finland
NA
80.9
7.4
8
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
7.4
345
2703
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.4
7.4
34
104
70891
ICD-8 Finland
Urticaria, Recidivans, Chronica
+∞
7.3
7
*
C07AA05
ATC
propranolol; systemic
1.8
7.3
141
869
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.3
7.3
18
29
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
7.3
91
480
X58
ICD-10 Finland
Exposure to other specified factors
2.0
7.3
93
496
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.4
7.3
60
264
N03AX16
ATC
pregabalin; oral
1.8
7.2
133
809
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
6.1
7.1
18
30
J31.0
ICD-10 Finland
Chronic rhinitis
2.4
7.0
58
254
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
7.0
123
734
J02AC01
ATC
fluconazole; systemic
1.6
7.0
285
2150
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.0
172
1140
R03AC13
ATC
formoterol; inhalant
3.0
7.0
37
126
R4110
NOMESCO Finland
Physiotherapy
1.7
6.9
160
1042
R05
ICPC
Cough
1.7
6.9
148
944
R03BA05
ATC
fluticasone; inhalant
1.8
6.7
127
779
R03AC03
ATC
terbutaline; inhalant
1.9
6.7
98
550
R03DA04
ATC
theophylline; systemic, rectal
3.8
6.6
26
70
J01FA06
ATC
roxithromycin; oral
1.6
6.6
250
1848
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.7
6.6
43
167
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.4
6.5
30
92
L15
ICPC
Knee symptom/complaint
1.8
6.5
122
746
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.5
156
1025
J45
ICD-10 Finland
Asthma
2.1
6.4
69
343
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
6.4
60
281
R60.0
ICD-10 Finland
Localized oedema
2.3
6.4
59
273
C08CA01
ATC
amlodipine; oral
1.7
6.4
148
960
X57
ICD-10 Finland
Unspecified privation
4.3
6.4
22
53
J01FA15
ATC
telithromycin; oral
2.2
6.3
65
316
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
6.3
82
442
R03BB04
ATC
tiotropium bromide; inhalant
2.6
6.3
44
177
J46
ICD-10 Finland
Status asthmaticus
3.7
6.2
25
69
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.1
549
4893
M54.5
ICD-10 Finland
Low back pain
1.6
6.1
215
1559
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.1
86
477
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
5.6
6.0
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
141
193
8.71
100.74
1.6
1.6
0.2
0.2
g/l
0.02
133
185
142
200
8.47
98.99
1.6
1.5
1.2
1.2
g/l
0.45
134
190
208
453
5.91
95.05
1.6
1.3
219.2
226.6
u/ml
0.04
203
411
58
32
19.51
73.13
1.4
1.4
5.9
6.2
ug/l
0.12
53
27
541
3301
3.12
46.79
6.9
6.0
0.2
0.2
e9/l
0.16
487
2930
527
3171
3.07
46.71
6.7
5.6
0.5
0.5
e9/l
0.18
468
2782
528
3185
3.06
46.50
6.8
5.6
0.0
0.0
e9/l
2.23
470
2790
389
2016
2.87
45.16
6.0
5.7
—
—
—
0
0
491
2876
2.93
45.11
6.8
5.7
0.6
0.7
%
4.05
472
2686
533
3288
2.99
43.96
6.7
5.6
2.0
2.0
e9/l
0.12
479
2941
497
2995
2.84
42.09
6.8
5.6
2.8
2.8
%
0.04
480
2791
497
3010
2.82
41.42
7.1
5.8
8.0
8.2
%
0.76
480
2833
562
3672
2.93
39.67
8.7
8.6
4.2
4.0
e9/l
1.81
506
3222
503
3118
2.75
39.11
7.1
5.6
29.0
29.4
%
0.45
484
2927
75
143
5.70
38.20
1.1
1.1
4.4
5.4
u/ml
0.25
61
76
496
3090
2.68
37.55
6.8
5.4
56.7
56.4
%
0.19
476
2908
71
140
5.48
34.82
1.1
1.1
0.7
0.8
u/ml
0.04
51
59
77
165
5.07
34.38
1.2
1.2
2.5
3.1
u/ml
0.14
53
67
70
143
5.28
32.99
1.1
1.1
1.1
6.2
u/ml
1.93
26
33
208
904
2.78
31.94
1.5
1.3
600.0
516.5
titre
0.21
37
195
625
4629
2.81
29.27
4.9
3.8
10.5
10.0
mm/h
0.44
601
4294
297
1595
2.40
28.82
6.6
6.2
—
—
—
0
0
41
56
7.67
28.65
1.3
1.3
0.1
0.4
u/ml
0.51
13
23
28
25
11.58
26.80
1.2
1.0
1.0
1.7
u/ml
0.30
23
13
114
432
2.92
22.06
1.2
1.2
—
—
—
0
0
138
593
2.61
20.93
1.3
1.2
158.0
144.8
iu/ml
0.15
43
248
59
156
4.01
20.10
1.2
2.0
10.9
10.3
g/l
0.43
51
141
33
53
6.46
19.87
1.1
1.1
0.2
3.2
u/ml
0.79
17
17
333
2103
2.02
19.69
4.5
3.4
30.2
86.4
e6/l
1.68
240
1402
416
2865
1.98
18.95
7.9
8.4
0.0
0.0
e9/l
0.60
332
2354
53
140
3.99
18.07
1.2
2.0
39.5
38.6
g/l
0.40
47
128
28
42
6.88
17.96
1.1
1.0
0.7
0.4
u/ml
—
6
7
71
232
3.27
17.63
1.2
1.2
—
—
—
0
0
45
107
4.40
17.61
1.2
1.1
6.1
6.8
u/ml
0.06
28
40
278
1709
1.98
17.22
3.7
2.9
16.8
60.0
e6/l
3.27
226
1279
42
99
4.43
16.62
1.1
1.1
0.1
0.7
u/ml
0.99
24
24
165
856
2.18
16.05
2.8
2.6
4.1
3.5
e6/l
0.25
95
437
91
363
2.71
15.83
2.6
2.7
68.3
67.3
g/l
0.75
82
333
575
4565
2.01
15.82
8.1
6.6
74.6
75.9
u/l
0.24
549
4271
255
1559
1.95
15.79
3.5
2.8
0.3
0.3
e6/l
0.12
206
1135
557
4383
1.96
15.61
5.1
4.0
—
—
—
0
0
253
1550
1.94
15.52
3.3
2.8
—
—
—
0
0
28
50
5.77
15.17
1.1
1.2
0.4
5.2
u/ml
0.66
14
21
46
126
3.82
14.91
1.2
1.1
4.2
6.2
u/ml
0.26
28
41
117
541
2.37
14.91
2.4
2.2
31.6
32.3
u/l
0.09
99
456
240
1475
1.91
14.40
1.5
1.4
2.3
2.2
g/l
0.17
133
939
528
4158
1.85
13.82
5.1
4.0
9.7
1098.4
e6/l
—
6
56
88
373
2.53
13.51
1.4
1.4
—
—
—
0
0
76
300
2.70
13.47
2.0
2.3
—
—
—
0
0
222
1365
1.88
13.11
2.5
2.4
1917.3
5544.5
umol/l
1.15
200
1201
68
259
2.78
12.90
1.3
1.3
1.4
1.5
u/ml
—
9
21
729
6511
3.02
12.88
16.3
11.2
18.2
20.7
mg/l
1.56
618
4994
621
5207
1.97
12.69
4.8
4.1
14.4
14.5
pmol/l
0.23
598
4792
163
913
1.99
12.66
3.7
3.3
950.5
348.2
ng/l
0.31
94
592
66
250
2.79
12.65
1.7
1.6
—
—
—
0
0
693
6056
2.36
12.62
5.8
4.7
1.7
2.0
mu/l
0.69
673
5647
196
1180
1.88
12.25
3.1
2.4
5.2
7.8
e6/l
2.04
175
1025
309
2142
1.74
12.01
2.1
1.8
95.9
96.8
pmol/l
0.15
160
1104
151
838
2.00
11.99
3.1
3.4
0.8
0.8
mmol/l
0.23
142
783
336
2387
1.72
11.93
4.9
5.5
1.2
1.2
mmol/l
0.73
310
2166
223
1413
1.81
11.77
3.7
3.2
—
—
—
0
0
278
1879
1.75
11.76
2.6
2.1
—
—
—
0
0
121
632
2.08
11.31
1.6
1.3
—
—
—
0
0
357
2609
1.68
11.19
2.6
2.3
73.3
75.1
nmol/l
0.62
340
2370
243
1600
1.76
11.16
3.7
3.5
7.4
7.4
ph
0.14
23
299
391
2948
1.66
10.71
5.4
5.5
10.6
10.4
umol/l
0.15
372
2774
103
517
2.14
10.66
16.5
14.1
1.3
1.1
inr
0.54
18
81
362
2685
1.65
10.51
5.5
6.1
1.2
1.2
mmol/l
0.14
324
2260
48
170
2.94
10.41
1.2
1.2
1.5
3.0
u/ml
—
6
20
231
1550
1.70
9.69
2.6
2.1
165.9
211.7
u/l
0.28
224
1466
45
163
2.87
9.38
1.2
1.3
—
—
—
0
0
185
1177
1.75
9.36
1.4
1.3
25.8
29.9
iu/ml
0.21
50
373
312
2277
1.62
9.35
5.0
4.4
36.6
36.5
g/l
0.13
293
2126
23
55
4.28
8.97
1.3
1.1
—
—
—
0
0
149
902
1.81
8.89
2.4
2.5
119.8
105.5
ug/g
0.26
119
711
409
3219
1.57
8.69
3.4
2.7
89.3
83.5
ug/l
0.26
390
3015
41
148
2.87
8.62
2.1
3.0
—
—
—
0
0
179
1153
1.72
8.59
1.4
1.2
10.3
12.7
u/ml
0.14
63
479
420
3346
1.56
8.31
4.4
4.4
6.4
6.5
mmol/l
0.18
392
3048
105
581
1.93
8.27
1.2
1.2
—
—
—
0
0
209
1423
1.64
8.07
2.1
1.7
0.8
0.9
mg/l
0.62
170
1048
172
1118
1.69
7.92
3.0
2.6
552.6
550.3
mosm/kgh2o
0.04
144
946
639
5661
1.73
7.78
19.0
13.5
13.6
13.5
%
0.52
631
5549
113
654
1.85
7.75
2.7
2.4
8.3
6.7
umol/l
0.34
98
555
205
1405
1.62
7.66
2.7
2.1
—
—
—
0
0
237
1707
1.56
7.10
1.4
1.3
3.6
1.9
u/ml
0.39
40
473
105
612
1.83
7.02
1.4
1.5
—
—
—
0
0
145
929
1.69
6.99
2.3
2.6
2.4
2.4
mmol/l
0.30
126
815
75
393
2.01
6.90
1.2
1.2
—
—
—
0
0
189
1300
1.60
6.87
4.3
4.0
—
—
—
0
0
254
1881
1.52
6.62
3.1
3.2
2.3
2.4
mmol/l
0.91
224
1684
128
808
1.70
6.49
2.2
2.2
14.6
13.7
umol/l
0.69
122
744
729
6814
2.18
6.35
11.8
8.8
25.3
25.5
u/l
0.07
715
6588
206
1469
1.55
6.35
2.3
2.0
2.5
3.0
mg/l
2.94
180
1250
102
610
1.77
6.26
2.1
1.9
372.1
380.4
nmol/l
0.17
97
567
6
0
+∞
6.26
1.0
0.0
0.3
—
u/ml
—
6
0
692
6364
1.82
6.22
15.8
12.0
3.9
3.9
mmol/l
1.94
679
6173
79
438
1.89
6.18
2.9
3.5
4.6
4.6
pmol/l
0.23
71
392
690
6343
1.80
6.18
15.5
12.0
139.5
139.6
mmol/l
0.32
678
6165
30
111
2.77
6.08
1.2
1.2
2.0
7.1
u/ml
1.53
13
48
322
2538
1.46
6.03
2.3
2.0
—
—
—
0
0
109
675
1.72
5.92
2.3
2.2
23.1
23.1
%
0.00
95
589
242
1810
1.49
5.89
3.0
2.6
—
—
—
0
0
386
3180
1.43
5.55
3.7
3.2
0.0
0.0
estimate
0.50
51
636
360
2933
1.42
5.49
4.6
4.0
—
—
—
0
0
171
1207
1.53
5.43
1.6
1.4
20.3
21.3
nmol/l
0.38
150
1047
22
74
3.03
5.29
2.2
2.3
—
—
—
0
0
58
310
1.94
5.08
1.1
1.1
—
—
—
0
0
42
200
2.16
5.01
1.2
1.2
—
—
—
0
0
246
1895
1.44
5.00
2.3
2.0
—
—
—
0
0
27
106
2.60
4.93
1.4
1.2
—
—
—
0
0
382
3200
1.38
4.70
5.5
4.4
0.0
0.0
estimate
0.50
53
652
14
38
3.73
4.66
1.0
1.3
—
—
—
0
0
7
5
14.11
4.58
1.0
1.0
—
—
—
0
0
207
1567
1.44
4.57
4.1
4.2
—
—
—
0
0
602
5461
1.46
4.54
5.0
4.8
38.6
38.5
mmol/mol
0.10
575
5131
20
70
2.91
4.52
1.1
1.3
—
—
—
0
0
384
3241
1.37
4.41
3.8
3.3
0.0
0.0
estimate
0.50
52
631
114
772
1.56
4.32
2.5
2.0
—
—
—
0
0
136
958
1.51
4.31
1.7
1.5
—
—
—
0
0
54
302
1.85
4.16
2.6
3.0
182.4
149.3
ng/l
0.22
49
272
19
69
2.80
4.04
2.4
4.6
100.7
70.0
u/ml
—
6
22
58
335
1.79
4.04
1.3
1.3
240.6
243.6
miu/ml
0.02
34
166
245
1946
1.38
4.03
3.7
3.0
48.6
54.5
ng/l
0.06
117
1093
17
59
2.92
3.92
2.7
2.6
—
—
—
0
0
71
439
1.68
3.90
2.4
2.6
4.1
4.0
e9/l
0.08
54
371
457
4012
1.34
3.82
3.5
3.1
—
—
—
0
0
67
415
1.67
3.67
3.0
2.3
—
—
—
0
0
30
143
2.14
3.63
2.4
1.9
—
—
—
0
0
667
6245
1.49
3.61
18.8
11.8
40.6
40.1
%
1.77
563
4972
77
498
1.61
3.56
3.6
2.8
1.6
1.8
%
1.47
68
447
110
774
1.49
3.50
1.3
1.2
—
—
—
0
0
15
52
2.92
3.48
1.0
1.0
—
—
—
0
0
758
7354
2.40
3.36
23.9
16.6
266.9
259.6
e9/l
2.51
749
7182
18
71
2.57
3.31
1.2
1.2
—
—
—
0
0
18
71
2.57
3.31
1.1
1.3
—
—
nmol/l
—
0
0
758
7360
2.36
3.24
23.9
16.5
4.5
4.5
e12/l
0.53
750
7173
758
7364
2.34
3.17
23.9
16.6
6.9
6.7
e9/l
2.66
748
7168
721
6902
1.64
3.12
12.6
10.4
—
—
—
0
0
638
5975
1.38
2.98
4.2
3.8
5.7
5.7
mmol/l
0.05
608
5514
24
114
2.14
2.97
1.3
1.1
—
—
—
0
0
199
1596
1.33
2.96
3.2
3.1
7.7
7.9
mmol/l
0.27
172
1361
59
377
1.61
2.90
6.1
7.9
—
—
—
0
0
24
116
2.10
2.85
1.5
1.1
—
—
—
0
0
12
42
2.89
2.76
1.8
2.8
—
—
—
0
0
97
700
1.44
2.73
2.2
1.5
—
—
—
0
0
216
1778
1.30
2.63
3.2
2.3
57.3
55.6
u/l
0.25
199
1640
15
61
2.49
2.63
1.3
1.3
—
—
—
0
0
15
61
2.49
2.63
1.3
1.3
0.3
0.4
g/l
0.03
15
44
15
61
2.49
2.63
1.3
1.3
2.8
2.6
g/l
0.38
15
43
15
61
2.49
2.63
1.3
1.3
5.3
6.4
g/l
1.57
15
44
47
292
1.65
2.60
1.4
1.2
—
—
—
0
0
9
25
3.63
2.58
1.0
1.2
—
—
—
0
0
29
157
1.88
2.55
1.6
1.4
318.5
313.7
ug/g
0.03
17
88
658
6231
1.37
2.55
4.5
4.1
2.8
2.9
mmol/l
0.40
628
5829
15
62
2.45
2.55
1.1
1.8
—
—
—
0
0
174
1397
1.32
2.54
3.8
3.4
1.0
1.0
kg/l
0.09
33
184
66
450
1.51
2.48
4.8
3.7
2.3
1.9
mmol/l
0.49
53
356
8
21
3.84
2.47
1.1
1.3
—
—
—
0
0
233
1953
1.28
2.45
8.5
6.6
1.2
1.1
inr
0.38
57
645
22
110
2.03
2.43
2.0
1.7
24976.1
14426.9
e6/l
0.34
17
80
16
70
2.31
2.42
1.3
2.2
—
—
—
0
0
10
34
2.97
2.42
1.1
1.1
139.3
163.1
iu/ml
—
10
34
8
22
3.66
2.37
1.0
1.0
—
—
—
0
0
101
756
1.39
2.33
1.3
1.2
—
—
—
0
0
186
1530
1.28
2.25
1.9
1.7
—
—
—
0
0
66
462
1.47
2.21
3.3
3.8
—
—
—
0
0
244
2083
1.25
2.16
1.5
1.6
—
—
—
0
0
16
74
2.19
2.16
1.9
1.5
—
—
—
0
0
27
152
1.80
2.14
1.5
2.0
62.6
293.7
ug/l
4.23
27
136
90
673
1.38
2.10
1.9
1.4
—
—
—
0
0
26
149
1.77
1.97
2.0
2.4
—
—
—
0
0
11
45
2.47
1.93
1.0
1.2
—
—
—
0
0
646
6160
1.29
1.92
4.2
3.8
4.7
4.8
mmol/l
1.73
618
5791
49
334
1.50
1.89
3.7
2.7
73.4
74.0
e9/l
0.04
36
250
7
22
3.20
1.88
1.1
1.2
—
—
—
0
0
68
495
1.41
1.88
4.7
8.8
0.6
1.1
mmol/l
0.64
51
387
17
86
2.00
1.86
1.3
1.0
—
—
—
0
0
10
40
2.52
1.84
2.9
2.4
—
—
—
0
0
643
6138
1.28
1.82
4.1
3.8
1.4
1.5
mmol/l
4.03
618
5757
24
138
1.76
1.81
1.2
1.1
—
—
—
0
0
621
5908
1.26
1.78
3.7
3.4
1.3
1.2
mmol/l
0.77
595
5524
63
457
1.41
1.78
1.4
1.4
—
—
—
0
0
49
339
1.48
1.77
2.5
1.7
—
—
—
0
0
64
468
1.40
1.74
4.3
3.9
64.6
31.0
ug/l
0.34
48
377
8
30
2.68
1.72
2.3
2.9
—
—
—
0
0
30
187
1.63
1.71
2.0
1.9
2.5
5.1
iu/l
—
10
70
60
436
1.41
1.69
2.3
1.7
—
—
—
0
0
40
581
0.67
1.68
4.1
3.6
—
—
—
0
0
60
437
1.40
1.67
2.3
1.7
—
—
—
0
0
6
19
3.17
1.66
2.7
2.7
—
—
—
0
0
13
62
2.12
1.66
1.1
2.1
—
—
—
0
0
60
439
1.40
1.63
2.3
1.7
—
—
—
0
0
31
198
1.59
1.62
3.1
2.0
—
—
—
0
0
5
14
3.59
1.61
3.8
2.9
54.5
56.3
%
—
5
14
60
441
1.39
1.60
2.3
1.7
—
—
—
0
0
85
662
1.32
1.57
1.6
1.3
—
—
—
0
0
86
673
1.31
1.54
5.3
5.4
1.1
1.0
mmol/l
0.55
81
630
20
115
1.76
1.53
3.5
4.1
27.8
27.3
mg/l
0.03
15
91
16
86
1.88
1.51
1.6
1.3
—
—
—
0
0
11
51
2.17
1.51
1.1
1.2
—
—
—
0
0
46
327
1.43
1.48
1.2
1.1
—
—
—
0
0
144
1207
1.24
1.48
1.8
1.7
—
—
—
0
0
40
277
1.47
1.48
3.0
3.0
—
—
—
0
0
109
888
1.26
1.44
1.6
1.7
921.0
1205.3
nmol/l
3.26
88
668
55
407
1.38
1.43
2.4
1.8
—
—
—
0
0
15
81
1.87
1.41
2.9
2.3
4.2
4.0
u/ml
0.08
15
71
31
207
1.52
1.37
1.3
1.2
—
—
—
0
0
13
68
1.93
1.34
1.8
1.5
—
—
—
0
0
13
68
1.93
1.34
1.8
1.5
—
—
—
0
0
13
68
1.93
1.34
1.8
1.5
—
—
—
0
0
13
68
1.93
1.34
1.8
1.5
—
—
—
0
0
39
275
1.44
1.33
3.4
6.9
—
—
—
0
0
40
285
1.43
1.30
2.2
1.7
—
—
—
0
0
178
1547
1.20
1.28
1.7
1.6
1.3
1.4
mmol/l
0.99
164
1317
9
44
2.06
1.27
1.2
1.1
—
—
—
0
0
22
139
1.60
1.24
1.5
1.2
266.4
245.0
u/ml
0.14
17
79
56
428
1.33
1.21
3.8
3.2
—
—
—
0
0
41
301
1.38
1.15
1.4
1.5
—
—
—
0
0
59
459
1.31
1.14
3.7
4.4
0.5
0.2
%
0.44
20
117
5
21
2.39
1.09
1.6
1.7
—
—
—
0
0
121
1032
1.20
1.08
1.7
1.5
—
—
—
0
0
56
438
1.30
1.06
3.4
4.2
0.4
0.6
%
0.57
11
96
41
306
1.36
1.06
4.5
2.1
—
—
—
0
0
7
33
2.13
1.05
1.0
1.0
—
—
—
0
0
14
82
1.72
1.05
1.6
1.8
—
—
—
0
0
152
1327
1.18
1.05
3.5
3.3
459.5
155.1
mg/l
0.34
102
847
15
90
1.68
1.04
2.2
1.7
—
—
—
0
0
7
34
2.07
1.03
3.9
8.3
—
—
—
0
0
160
1406
1.17
1.02
4.2
4.1
12.7
9.7
mg/mmol
0.24
108
884
5
106
0.47
1.01
8.0
2.8
—
—
—
0
0
22
147
1.51
1.01
1.1
1.9
—
—
—
0
0
7
35
2.01
1.00
1.0
1.1
—
—
—
0
0
25
173
1.46
0.98
1.3
1.6
456.5
455.2
mg/l
0.01
25
163
16
100
1.61
0.97
1.2
1.1
11.0
115.9
iu/ml
—
5
30
0
31
0.00
0.96
0.0
1.0
—
—
—
0
0
9
51
1.77
0.94
1.2
1.3
—
—
—
0
0
60
482
1.27
0.94
3.8
4.3
1.9
1.1
%
0.41
20
130
6
28
2.15
0.91
1.0
1.3
19328.3
36165.6
e6/l
—
6
16
16
102
1.58
0.91
1.2
1.0
—
—
—
0
0
6
30
2.01
0.87
1.0
1.3
1407.7
2238.2
e6/l
—
6
21
54
436
1.26
0.83
3.2
4.5
0.0
0.1
%
0.71
12
99
38
293
1.31
0.83
1.4
1.4
—
—
—
0
0
19
131
1.46
0.79
2.0
1.3
—
—
—
0
0
22
157
1.41
0.77
1.2
1.8
37.2
8.6
e6/l
0.36
17
124
22
157
1.41
0.77
1.2
1.8
99.2
164.1
e6/l
0.26
17
128
28
210
1.35
0.74
10.9
9.1
—
—
—
0
0
7
39
1.80
0.72
1.1
1.1
—
—
—
0
0
37
291
1.29
0.72
1.4
1.4
—
—
—
0
0
74
865
0.84
0.72
1.3
1.3
—
—
—
0
0
9
57
1.59
0.71
1.1
1.1
—
—
—
0
0
32
249
1.30
0.68
2.1
2.2
—
—
—
0
0
14
94
1.50
0.67
2.6
2.6
—
—
—
0
0
30
232
1.30
0.67
7.3
11.3
—
—
—
0
0
5
28
1.79
0.66
2.6
3.4
—
—
—
0
0
61
515
1.20
0.65
2.1
2.2
14344.6
4897.5
u/l
0.82
25
219
20
146
1.38
0.64
1.9
1.7
—
—
—
0
0
42
510
0.81
0.62
1.9
1.7
—
—
—
0
0
58
491
1.20
0.61
1.5
1.4
35.5
23.8
iu/l
1.52
52
414
16
113
1.42
0.61
1.3
1.1
—
—
—
0
0
8
53
1.51
0.58
1.5
3.1
—
—
—
0
0
6
35
1.72
0.57
1.2
1.2
—
—
—
0
0
21
158
1.34
0.57
1.4
1.1
—
—
—
0
0
8
125
0.64
0.55
1.3
1.4
—
—
—
0
0
59
507
1.18
0.54
2.6
3.5
—
—
—
0
0
6
39
1.54
0.53
1.3
2.7
—
—
—
0
0
7
107
0.65
0.49
4.3
2.8
9.4
9.1
kpa
—
7
107
7
107
0.65
0.49
4.3
2.8
4.9
4.9
kpa
—
7
107
12
85
1.42
0.47
1.4
1.3
—
—
—
0
0
93
839
1.12
0.46
1.8
1.9
—
—
—
0
0
7
49
1.43
0.46
1.1
2.2
—
44.0
—
0
6
239
2521
0.92
0.45
2.3
2.5
—
—
—
0
0
100
908
1.12
0.45
4.8
4.2
2.0
2.1
ug/l
0.08
93
822
5
31
1.62
0.43
1.0
1.4
—
—
—
0
0
5
32
1.57
0.42
1.2
1.6
—
—
—
0
0
20
158
1.27
0.42
1.4
1.1
—
—
—
0
0
27
222
1.22
0.41
4.6
2.9
0.8
0.7
%
0.71
27
214
0
15
0.00
0.41
0.0
2.5
—
4702.1
—
0
8
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
10.0
—
—
—
0
0
13
171
0.76
0.39
1.3
1.2
—
—
—
0
0
37
431
0.85
0.39
2.5
3.5
1.2
1.2
mmol/l
0.33
28
364
5
36
1.39
0.38
3.2
5.4
12.3
11.5
%
—
5
36
12
89
1.35
0.38
5.1
4.6
—
—
—
0
0
8
111
0.72
0.37
1.6
1.4
—
—
—
0
0
20
161
1.25
0.37
1.2
1.2
—
—
—
0
0
9
69
1.31
0.37
1.3
1.1
25.8
32.4
mg/l
—
9
50
5
37
1.35
0.37
6.4
1.9
—
—
—
0
0
6
43
1.40
0.35
1.0
1.3
—
—
—
0
0
10
73
1.37
0.34
1.6
1.7
—
—
—
0
0
21
173
1.22
0.33
6.6
4.6
—
—
—
0
0
7
54
1.30
0.30
7.6
3.3
—
—
—
0
0
195
1863
1.06
0.29
3.0
2.9
—
—
—
0
0
10
76
1.32
0.28
1.4
1.4
—
—
—
0
0
8
64
1.25
0.27
1.3
1.3
43.0
37.1
nmol/l
—
8
55
8
65
1.23
0.27
1.3
1.1
223.1
219.5
mg/l
—
8
54
24
274
0.87
0.23
1.4
1.5
9.2
10.1
u/l
0.14
19
217
5
40
1.25
0.22
1.0
1.5
—
2335.5
—
0
6
39
353
1.11
0.22
2.4
2.2
11.2
12.7
nmol/l
0.51
34
324
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
3.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
7.8
—
—
—
0
0
5
43
1.16
0.21
1.8
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
6.3
—
25.5
—
0
14
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
153
1472
1.05
0.19
3.6
3.2
—
—
—
0
0
7
58
1.21
0.18
1.3
1.3
—
—
—
0
0
7
62
1.13
0.17
4.4
2.3
106.6
106.5
mmol/l
—
7
62
7
62
1.13
0.17
4.4
2.3
—
—
—
0
0
7
62
1.13
0.17
4.4
2.3
4.0
4.0
mmol/l
—
7
62
6
80
0.75
0.15
2.5
2.1
—
—
—
0
0
22
200
1.10
0.12
2.7
3.7
0.1
0.3
g/l
—
8
82
56
535
1.05
0.10
1.3
1.4
—
—
—
0
0
12
135
0.89
0.10
3.6
3.9
—
—
—
0
0
6
57
1.05
0.08
1.3
1.2
—
—
—
0
0
22
236
0.93
0.08
5.3
3.8
—
—
—
0
0
7
67
1.05
0.08
1.6
2.1
—
—
—
0
0
18
166
1.09
0.08
6.0
4.0
1.2
1.4
mg/l
0.55
18
154
117
1149
1.02
0.05
1.4
1.6
83000436.9
26348347.2
pmol/l
0.30
100
983
169
1709
0.99
0.04
3.8
3.6
0.0
0.0
estimate
1.34
53
644
40
389
1.03
0.03
1.4
1.5
260.7
300.7
mu/l
0.88
35
353
31
318
0.97
0.02
4.8
3.6
5.2
5.1
kpa
0.10
26
300
12
113
1.06
0.02
1.7
2.2
136.5
133.0
g/l
—
6
83
10
94
1.06
0.01
2.8
4.1
—
—
—
0
0
13
126
1.03
0.00
2.5
4.0
57.5
56.6
%
0.10
13
126
10
97
1.03
0.00
4.3
3.0
—
—
—
0
0
13
127
1.02
0.00
5.0
3.6
9.0
8.4
kpa
0.47
13
122
30
296
1.01
0.00
1.5
1.3
—
—
—
0
0
54
536
1.01
0.00
2.6
2.8
0.8
0.7
ug/l
0.08
32
317
13
128
1.02
0.00
10.2
2.7
7.4
7.4
ph
—
7
107
12
121
0.99
0.00
2.6
3.7
4.1
4.2
e9/l
0.05
12
121
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
33.9
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
314.0
—
0
5
0
5
0.00
0.00
0.0
2.6
—
194.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
10.8
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
15.3
—
0
7
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
11
110
1.00
0.00
1.5
1.2
—
—
—
0
0
5
49
1.02
0.00
1.6
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
5
50
1.00
0.00
1.4
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_URTICA_IDIOPAT and mortality.

Females

Parameter HR [95% CI] p-value
L12_URTICA_IDIOPAT 1.082 [0.86, 1.37] 0.511
Birth year 0.995 [0.99, 1.0] 0.272

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 2558 females with L12_URTICA_IDIOPAT died.

Males

Parameter HR [95% CI] p-value
L12_URTICA_IDIOPAT 1.073 [0.8, 1.43] 0.632
Birth year 0.991 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1446 males with L12_URTICA_IDIOPAT died.

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_IDIOPAT.

N-year risk Females Males
1 0.094% 0.229%
5 0.676% 1.245%
10 1.577% 3.287%
15 3.005% 6.357%
20 5.357% 10.726%

Relationships between endpoints

↥

Index endpoint: L12_URTICA_IDIOPAT – Idiopathic urticaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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