Allergic contact dermatitis due to drugs in contact with skin

ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L23.3#

1 out of 7 registries used, show all original rules.

833

4. Check minimum number of events

None

833

5. Include endpoints

None

833

6. Filter based on genotype QC (FinnGen only)

818

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5347 3692 1635
Only index persons 5018 3503 1515
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.05
Only index persons 0.11 0.13 0.06
Median age at first event (years)
Whole population 53.77 53.75 53.80
Only index persons 53.05 52.95 53.27

-FinnGen-

Key figures

All Female Male
Number of individuals 818 579 239
Unadjusted period prevalence (%) 0.18 0.21 0.11
Median age at first event (years) 55.36 53.13 60.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
833
Matched controls
8330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
XQ802
NOMESCO Finland
Epicutan test
44.2
307.7
397
168
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
4503599627370496.0
307.7
830
5
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
18.5
307.7
424
443
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
61.7
276.8
156
31
XQ800
NOMESCO Finland
Prick test
14.0
273.6
308
336
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
47.5
249.7
149
38
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.0
141.6
384
1045
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
38.2
137.8
86
25
E0000UV, ,
ATC
5.0
108.0
570
2523
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
38.4
103.0
64
18
L20.0
ICD-10 Finland
Besnier prurigo
6.8
101.4
182
327
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
55.6
100.0
57
11
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
9.3
99.9
130
162
D07AC13
ATC
mometasone; topical
4.1
87.1
419
1664
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
20.4
84.8
66
35
D07AC01
ATC
betamethasone; topical
3.9
83.1
476
2111
L30.3
ICD-10 Finland
Infective dermatitis
8.8
74.3
99
126
E000001, ,
ATC
3.8
70.7
298
1055
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.3
66.6
214
623
D07AB08
ATC
desonide; topical
4.4
65.2
197
547
R06AE07
ATC
cetirizine; oral
3.2
59.3
515
2772
D07AD01
ATC
clobetasol; topical
3.5
52.2
235
848
D11AH01
ATC
tacrolimus; topical
19.5
52.1
41
22
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
11.0
51.3
56
54
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
47.4
359
1733
XQ899
NOMESCO Finland
Other assessment of skin
19.8
46.0
36
19
H02AB06
ATC
prednisolone; systemic
2.8
44.7
505
2967
T78.4
ICD-10 Finland
Allergy, unspecified
5.6
43.9
88
171
D07BC01
ATC
betamethasone and antiseptics; topical
3.6
43.8
171
558
E000006, ,
ATC
4.2
41.2
121
323
D07CC01
ATC
betamethasone and antibiotics; topical
3.3
40.6
184
657
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
11.6
39.1
41
37
D02AE01
ATC
carbamide; topical
4.3
38.9
110
285
D09AB01
ATC
zinc bandage without supplements; topical
9.0
37.3
47
55
TQW80
NOMESCO Finland
Local dermatologic skincare
7.2
36.9
56
82
D02AX
ATC
Other emollients and protectives
6.1
36.8
66
115
R06AX27
ATC
desloratadine; oral
2.6
35.8
325
1668
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
35.2
134
427
E000002, ,
ATC
3.3
34.5
151
525
XQ801
NOMESCO Finland
Intracutantest
13.8
34.1
32
24
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.5
34.1
69
135
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
31.1
256
1240
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
10.4
31.1
35
35
R06AE09
ATC
levocetirizine; oral
2.7
28.5
180
763
C01CA24
ATC
epinephrine; parenteral
3.6
28.3
102
312
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.2
28.1
122
419
L30.8
ICD-10 Finland
Other specified dermatitis
5.8
27.1
51
93
L50.0
ICD-10 Finland
Allergic urticaria
5.9
26.3
48
85
D07XC01
ATC
betamethasone; topical
2.9
26.0
141
549
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.4
25.8
102
330
L30.0
ICD-10 Finland
Nummular dermatitis
4.8
25.8
60
132
N05BB01
ATC
hydroxyzine; systemic
3.6
25.3
90
272
H02AB07
ATC
prednisone; oral
2.6
24.2
158
677
E000003, ,
ATC
4.0
23.0
69
185
D07AA02
ATC
hydrocortisone; topical
2.5
22.9
163
726
R06AX22
ATC
ebastine; oral
2.4
22.8
190
910
J01FF01
ATC
clindamycin; systemic
2.1
21.1
269
1529
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
5.3
20.4
42
83
E000004, ,
ATC
5.7
20.2
38
69
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.5
20.1
144
641
L20
ICD-10 Finland
Atopic dermatitis
4.9
19.6
44
94
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.3
17.6
71
232
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.9
17.1
52
141
L23
ICD-10 Finland
Allergic contact dermatitis
13.6
17.1
29
22
S29
ICPC
Skin symptom/complaint other
2.1
16.7
184
978
E000007, ,
ATC
3.1
16.3
70
237
J01DB01
ATC
cefalexin; oral
2.3
16.0
707
5942
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
34.1
15.8
20
6
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
15.1
15.4
25
17
H02AB04
ATC
methylprednisolone; systemic
2.2
15.4
147
737
S87
ICPC
Dermatitis/atopic eczema
4.5
14.9
37
86
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
14.8
200
1141
A46
ICD-10 Finland
Erysipelas
2.3
14.8
127
609
XQ848
NOMESCO Finland
Dermatological photography
4.1
14.5
40
101
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.6
14.4
34
76
L50.9
ICD-10 Finland
Urticaria, unspecified
3.5
14.3
51
154
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
13.9
383
2720
S88
ICPC
Dermatitis contact/allergic
4.6
13.6
32
71
L50.8
ICD-10 Finland
Other urticaria
4.8
13.6
31
67
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.3
13.5
53
170
D05BB02
ATC
acitretin; oral
4.8
13.4
30
64
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
13.3
169
940
J02AC01
ATC
fluconazole; systemic
1.7
13.0
366
2601
L04AX03
ATC
methotrexate; systemic
2.3
12.7
99
455
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
4.4
12.5
31
72
XQ820
NOMESCO Finland
Exposure to medicinal substance
16.2
12.2
19
12
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
12.0
198
1199
L29.9
ICD-10 Finland
Pruritus, unspecified
3.7
11.9
37
102
R06AX13
ATC
loratadine; oral
2.0
11.9
146
801
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
11.9
316
2197
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
5.0
11.3
24
49
R03DC03
ATC
montelukast; oral
1.9
11.2
157
900
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
11.1
128
685
D07AC14
ATC
methylprednisolone aceponate; topical
2.9
11.0
53
192
J02AC02
ATC
itraconazole; systemic
1.9
10.9
164
961
SPAT1263
SPAT
Sampling
1.6
10.8
350
2544
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
10.8
42
134
D06AX01
ATC
fusidic acid; topical
2.2
10.8
94
452
ZXX05
NOMESCO Finland
Extent of procedure, 5 units
28.4
10.7
14
5
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
5.7
10.7
20
36
R03AC02
ATC
salbutamol; inhalant
1.6
10.6
474
3729
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
5.1
10.6
22
44
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
10.5
352
2577
C05AA08
ATC
fluocortolone; rectal, topical
2.0
10.5
126
684
D07CB01
ATC
triamcinolone and antibiotics; topical
4.5
10.3
25
57
R01AD08
ATC
fluticasone; nasal
1.7
10.3
243
1623
D07XB05
ATC
dexamethasone; topical
3.6
10.1
33
94
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
9.9
246
1662
R03BA05
ATC
fluticasone; inhalant
1.8
9.9
162
972
L26
ICD-10 Finland
Exfoliative dermatitis
26.4
9.8
13
5
A92
ICPC
Allergy/allergic reaction NOS
3.3
9.8
36
111
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.1
9.6
41
139
J01DA01
ATC
[U] cefalexin
1.6
9.5
515
4192
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
4.2
9.5
25
61
L30.4
ICD-10 Finland
Erythema intertrigo
5.0
9.3
20
41
A02BC05
ATC
esomeprazole; systemic
1.6
9.2
336
2488
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
9.2
102
537
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
3.0
9.2
40
137
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
9.2
359
2704
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.7
9.1
28
77
J01CF05
ATC
flucloxacillin; systemic
2.5
9.0
59
250
ZXX03
NOMESCO Finland
Extent of procedure, 3 units
12.7
8.9
15
12
L30.1
ICD-10 Finland
Dyshidrosis [pompholyx]
10.8
8.8
16
15
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
8.7
85
427
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.4
8.7
58
248
J01AA04
ATC
lymecycline; systemic
1.9
8.6
117
661
D11AX14
ATC
[U] tacrolimus
11.7
8.6
15
13
A02BC02
ATC
pantoprazole; systemic
1.6
8.4
548
4589
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.3
8.4
65
297
D11AH02
ATC
pimecrolimus; topical
12.9
8.4
14
11
D06
ICPC
Abdominal pain localized other
2.2
8.3
74
359
D05AX52
ATC
calcipotriol, combinations; topical
2.6
8.3
48
192
S76
ICPC
Skin infection other
2.5
8.1
50
206
L25.9
ICD-10 Finland
Unspecified contact dermatitis, unspecified cause
8.2
8.1
17
21
L23.7
ICD-10 Finland
Allergic contact dermatitis due to plants, except food
33.7
8.1
10
*
D07AB01
ATC
clobetasone; topical
2.9
8.0
37
131
Z04.3
ICD-10 Finland
Examination and observation following other accident
3.6
8.0
26
74
S06
ICPC
Rash localized
2.5
8.0
50
208
R06.2
ICD-10 Finland
Wheezing
2.7
8.0
43
166
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
7.9
152
954
L17
ICPC
Foot/toe symptom/complaint
1.6
7.7
238
1683
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
7.7
278
2037
R01AD09
ATC
mometasone; nasal
1.5
7.7
376
2939
L23.4
ICD-10 Finland
Allergic contact dermatitis due to dyes
25.3
7.6
10
*
R51.80
ICD-10 Finland
Headache
1.7
7.5
136
837
J01MA12
ATC
levofloxacin; systemic
1.7
7.4
147
928
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.7
7.4
40
155
XCK00
NOMESCO Finland
Perimetry
2.3
7.4
55
248
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
7.3
157
1014
L01
ICPC
Neck symptom/complaint
1.7
7.2
132
815
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
7.2
102
583
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
7.4
7.2
16
22
L29.8
ICD-10 Finland
Other pruritus
6.7
7.1
17
26
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
4.3
7.0
18
43
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
3.4
7.0
25
76
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.4
7.0
46
196
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.0
180
1216
L43.8
ICD-10 Finland
Other lichen planus
3.8
6.9
21
57
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.9
45
191
L50.3
ICD-10 Finland
Dermatographic urticaria
3.4
6.9
24
72
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.9
173
1162
WQ000
NOMESCO Finland
Hyposensibilisation
11.0
6.8
12
11
H60.8
ICD-10 Finland
Other otitis externa
2.9
6.8
32
115
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
9.4
6.8
13
14
Z51.6
ICD-10 Finland
Desensitization to allergens
6.2
6.8
17
28
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
4.3
6.8
17
40
H01.0
ICD-10 Finland
Blepharitis
2.1
6.7
62
305
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.2
6.7
55
258
D11AH04
ATC
alitretinoin; oral
22.7
6.7
9
*
NF1AA
NOMESCO Finland
Hip X-ray examination
2.0
6.7
72
376
N02BE01
ATC
paracetamol; systemic, rectal
1.7
6.6
726
6631
SPAT1229
SPAT
Assessment of need for aid
2.1
6.6
61
300
EKA10
NOMESCO Finland
iopsy of buccal mucosa
3.4
6.6
23
69
S21
ICPC
Skin texture symptom/complaint
1.8
6.6
113
685
H25.8
ICD-10 Finland
Other senile cataract
1.9
6.5
83
459
D07AC03
ATC
desoximetasone; topical
3.7
6.5
20
55
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
6.5
102
603
SPAT1255
SPAT
Intravenous administration of medicine
2.2
6.4
55
263
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.4
6.4
42
179
WZC30
NOMESCO Finland
Teaching
1.7
6.4
123
770
D07XB02
ATC
triamcinolone; topical
4.1
6.4
17
42
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
6.3
108
653
L24.0
ICD-10 Finland
Irritant contact dermatitis due to detergents
9.3
6.3
12
13
C03CA01
ATC
furosemide; systemic
1.5
6.3
214
1537
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.0
6.3
68
356
N03AX16
ATC
[U] pregabalin
1.6
6.2
189
1323
M75.3
ICD-10 Finland
Calcific tendinitis of shoulder
3.7
6.2
19
52
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.8
6.2
30
110
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.4
6.2
21
62
M79.6
ICD-10 Finland
Pain in limb
1.4
6.2
334
2632
M25.5
ICD-10 Finland
Pain in joint
1.5
6.1
265
1998
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.5
6.0
20
58
T78.3
ICD-10 Finland
Angioneurotic oedema
5.2
6.0
17
33

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
154
446
4.01
47.15
1.5
1.2
578.27
208.14
u/ml
1.79
147
409
92
295
3.38
23.59
1.4
1.2
—
—
—
0
0
179
831
2.47
23.07
2.0
1.4
—
—
—
0
0
151
655
2.59
22.42
4.5
4.3
—
—
—
0
0
456
3107
2.03
21.99
7.1
5.7
0.68
0.67
%
0.18
429
2898
657
5136
2.32
21.89
4.8
4.1
12.43
12.01
mm/h
0.30
608
4735
463
3207
2.00
20.91
7.2
5.6
3.30
2.81
%
3.44
437
3003
463
3225
1.98
20.38
7.6
5.9
8.60
8.42
%
0.65
439
3024
467
3275
1.97
20.01
7.0
5.5
55.83
57.15
%
1.59
442
3079
471
3318
1.97
19.86
7.4
5.7
28.24
28.03
%
0.15
445
3120
313
1965
1.95
18.11
4.8
3.7
—
—
—
0
0
489
3555
1.91
18.04
6.9
5.9
0.24
0.19
e9/l
3.23
444
3156
48
120
4.18
17.59
1.1
1.1
1.73
2.76
u/ml
0.35
27
67
482
3526
1.87
17.03
7.0
5.5
2.04
1.90
e9/l
0.49
443
3154
44
107
4.29
16.72
1.1
1.0
7.31
3.12
u/ml
0.55
23
57
471
3433
1.86
16.70
6.9
5.5
0.04
0.04
e9/l
1.58
425
2996
470
3427
1.85
16.61
6.9
5.5
0.61
0.56
e9/l
2.93
427
2985
439
3232
1.76
14.10
7.5
6.1
—
—
—
0
0
37
91
4.21
13.86
1.3
1.3
—
—
—
0
0
172
954
2.01
13.71
1.5
1.3
641.05
533.08
titre
0.25
38
211
317
2148
1.77
13.44
2.9
2.4
53.51
58.29
u/l
1.08
288
1988
146
774
2.07
13.13
2.3
1.6
—
—
—
0
0
638
5300
1.87
12.97
9.4
7.3
77.25
77.83
u/l
0.14
604
4973
569
4596
1.75
12.38
4.2
3.0
46.33
44.52
u/l
0.24
520
4295
510
4010
1.70
12.11
9.3
8.8
4.08
4.05
e9/l
0.11
458
3523
377
2739
1.69
12.07
2.2
2.0
98.67
96.12
pmol/l
0.39
190
1392
197
1205
1.83
11.50
1.7
1.7
1044.12
1194.24
nmol/l
1.41
141
904
18
12
15.30
11.34
1.0
1.1
—
—
—
0
0
63
252
2.62
10.84
4.9
4.1
25.38
24.96
mmol/l
0.58
56
240
431
3305
1.63
10.74
7.7
6.5
1.22
1.22
mmol/l
0.72
371
2812
89
426
2.22
10.32
1.5
1.3
56.38
36.82
au/ml
—
5
26
19
19
10.20
10.05
1.1
1.0
12.63
14.94
u/ml
—
7
13
451
3532
1.60
10.04
6.9
6.0
10.05
10.96
umol/l
1.76
424
3353
95
472
2.14
10.03
2.9
2.4
13.19
25.12
au/ml
—
7
29
395
2998
1.60
10.02
6.2
5.7
1.22
1.22
mmol/l
0.59
344
2727
34
101
3.47
9.82
1.0
1.1
0.56
0.68
u/ml
0.14
18
46
572
4762
1.64
9.75
5.6
4.3
—
—
—
0
0
117
648
1.94
9.16
2.3
2.0
380.96
374.99
nmol/l
0.10
105
600
67
299
2.35
9.15
4.7
3.5
—
—
—
0
0
484
3909
1.57
9.03
5.0
4.5
6.52
6.58
mmol/l
0.32
455
3650
392
3033
1.55
8.76
14.6
13.7
1.20
1.22
inr
0.21
101
905
339
2558
1.55
8.37
4.5
3.5
197.53
50.22
ng/l
0.40
235
1725
245
1720
1.60
8.26
2.3
2.1
2.76
3.01
mg/l
0.97
213
1462
82
419
2.06
8.04
4.7
3.5
5.17
5.10
kpa
0.41
76
404
768
7067
2.11
7.92
20.1
15.1
139.60
139.67
mmol/l
0.36
744
6872
719
6492
1.79
7.64
6.1
4.8
1.89
2.06
mu/l
0.45
650
5959
768
7088
2.07
7.52
20.4
15.2
3.95
3.95
mmol/l
0.02
744
6882
630
5507
1.59
7.50
5.1
4.0
14.90
14.71
pmol/l
1.05
564
5007
254
1848
1.54
7.16
3.1
3.0
1421.17
1172.68
ng/l
0.41
200
1569
371
2928
1.48
7.04
2.7
2.3
79.35
77.14
nmol/l
0.76
323
2614
157
1028
1.65
6.89
2.3
2.3
12.75
13.13
umol/l
0.30
147
954
273
2036
1.51
6.79
2.3
2.1
167.17
203.98
u/l
0.47
258
1917
98
569
1.82
6.60
1.3
1.2
—
—
—
0
0
785
7355
2.17
6.55
13.8
10.0
25.54
24.98
u/l
0.49
766
7098
29
101
2.94
6.53
1.3
1.2
—
—
—
0
0
29
102
2.91
6.42
1.0
1.0
2.62
1.46
u/ml
0.30
16
55
19
51
3.79
6.39
1.8
1.1
0.56
1.00
u/ml
0.20
13
26
728
6684
1.71
6.16
5.1
4.4
5.79
5.87
mmol/l
1.08
652
6098
147
973
1.62
6.15
2.4
1.9
—
—
—
0
0
236
1744
1.49
6.02
5.2
4.1
—
—
—
0
0
51
244
2.16
5.96
1.6
1.6
—
—
—
0
0
14
22
6.45
5.87
1.0
1.0
0.58
0.85
u/ml
—
5
11
216
1576
1.50
5.84
1.9
1.6
0.90
1.13
mg/l
1.11
159
1209
142
945
1.61
5.79
2.3
2.2
2.41
2.34
g/l
0.67
132
874
42
188
2.30
5.76
5.0
4.3
—
—
—
0
0
24
82
2.98
5.61
1.0
1.0
12.56
2.73
u/ml
0.88
15
37
530
4588
1.43
5.59
5.6
4.4
403.29
3005.55
e6/l
—
7
71
219
1621
1.48
5.47
1.4
1.3
3.90
1.91
u/ml
0.53
39
435
744
6917
1.71
5.41
19.7
13.4
18.80
22.56
mg/l
2.83
625
5421
216
1601
1.47
5.35
1.6
1.5
20.18
21.50
nmol/l
0.51
177
1356
85
506
1.76
5.28
4.3
4.0
0.44
0.61
%
0.54
32
166
22
76
2.95
5.06
1.0
1.1
15.54
5.43
u/ml
—
8
27
28
112
2.55
4.92
1.1
1.5
—
—
—
0
0
87
534
1.70
4.85
2.1
2.9
66.12
66.95
g/l
0.41
77
490
62
344
1.87
4.85
4.8
3.4
—
—
—
0
0
193
1429
1.46
4.75
1.3
1.5
2.49
2.31
g/l
0.67
116
872
46
236
2.00
4.53
3.0
3.3
0.24
0.33
g/l
0.52
18
91
128
882
1.53
4.46
2.6
2.3
21.10
22.78
%
0.93
107
763
84
525
1.67
4.39
4.6
4.1
0.06
0.13
%
0.61
31
162
80
494
1.69
4.38
4.6
4.2
0.03
0.78
%
0.60
29
135
373
3123
1.35
4.37
2.9
2.7
108.99
111.56
ug/l
0.08
349
2881
11
20
5.56
4.30
1.1
1.5
91.82
76.25
nmol/24h
0.24
11
20
728
6807
1.55
4.27
4.9
4.3
4.72
4.72
mmol/l
0.03
666
6311
88
562
1.63
4.24
4.5
4.0
0.80
1.05
%
0.53
35
198
342
2836
1.35
4.23
6.7
4.5
35.35
35.67
g/l
0.50
322
2651
270
2159
1.37
4.21
3.0
2.3
—
—
—
0
0
170
1256
1.44
4.19
1.3
1.3
45.23
31.37
iu/ml
0.34
51
425
76
470
1.68
4.14
2.5
2.9
7.99
5.63
e9/l
0.25
57
384
800
7686
2.03
4.01
27.1
19.9
39.16
39.84
%
1.78
763
7215
800
7688
2.02
3.97
27.4
19.9
255.17
254.16
e9/l
0.16
786
7496
12
27
4.49
3.94
3.9
2.9
42600.00
35452.04
ug/l
1.15
12
27
146
1060
1.46
3.94
3.5
3.2
0.84
0.82
mmol/l
1.02
129
990
800
7691
2.01
3.92
27.3
19.8
30.27
30.26
pg
0.08
791
7577
800
7691
2.01
3.92
27.3
19.8
91.06
90.96
fl
0.28
791
7578
21
82
2.60
3.91
10.8
5.4
10.17
11.63
mg/l
1.02
21
73
278
2255
1.35
3.91
3.7
3.1
31.42
30.54
u/l
0.14
262
2146
800
7692
2.01
3.90
27.4
19.9
4.43
4.46
e12/l
1.04
782
7478
800
7692
2.01
3.90
27.4
19.9
6.86
6.65
e9/l
1.02
784
7477
273
2209
1.35
3.90
3.8
3.0
—
—
—
0
0
800
7695
2.00
3.85
27.6
20.0
133.37
134.20
g/l
0.99
791
7579
78
496
1.63
3.83
1.4
1.4
—
—
—
0
0
722
6773
1.50
3.80
4.9
4.3
1.48
1.51
mmol/l
1.09
653
6245
122
862
1.49
3.77
2.9
2.3
185.14
122.52
ug/g
0.92
90
687
6
5
12.07
3.77
1.5
1.4
105.67
67.20
ng/l
—
6
5
340
2857
1.32
3.71
2.1
2.1
—
—
—
0
0
109
758
1.50
3.64
2.3
2.4
11.02
7.19
umol/l
0.42
88
652
49
278
1.81
3.63
1.1
1.6
—
8.06
—
0
8
73
464
1.63
3.60
1.8
2.4
—
—
—
0
0
699
6541
1.43
3.49
4.5
3.8
1.29
1.26
mmol/l
0.46
629
5990
206
1630
1.35
3.34
3.0
2.2
—
—
—
0
0
733
6935
1.47
3.30
5.3
4.8
2.81
2.79
mmol/l
0.13
664
6394
100
698
1.49
3.29
2.0
2.6
1.86
1.83
%
0.09
83
628
55
333
1.70
3.28
2.5
2.4
—
—
—
0
0
132
978
1.42
3.18
1.3
1.2
—
—
—
0
0
36
196
1.87
3.07
2.0
3.8
56.50
82.83
mg/l
0.33
29
155
157
1206
1.37
3.06
1.3
1.3
12.47
11.74
u/ml
0.03
54
464
41
234
1.79
3.02
1.5
2.1
9.90
10.59
g/l
0.46
35
214
134
1005
1.40
3.01
1.9
1.9
29.22
29.53
s
0.28
129
973
18
76
2.40
2.91
3.4
3.7
—
—
—
0
0
16
64
2.53
2.88
1.3
1.3
0.39
0.35
g/l
—
8
44
16
64
2.53
2.88
1.3
1.3
5.81
7.18
g/l
—
8
46
16
64
2.53
2.88
1.3
1.3
3.07
2.48
g/l
—
8
44
372
3240
1.27
2.87
3.1
2.5
—
—
—
0
0
755
7221
1.49
2.84
18.7
12.8
—
—
—
0
0
672
6304
1.34
2.83
6.4
5.5
39.76
39.39
mmol/mol
0.45
603
5839
84
586
1.48
2.79
6.2
3.2
1.82
2.02
mmol/l
0.15
78
473
107
782
1.42
2.79
1.2
1.3
—
—
—
0
0
18
78
2.34
2.76
1.4
1.3
—
—
—
0
0
35
196
1.82
2.76
2.0
3.8
33.83
45.64
mg/l
0.31
28
155
16
66
2.45
2.72
1.3
1.2
—
—
—
0
0
276
2331
1.28
2.71
2.9
3.3
2.34
2.35
mmol/l
0.96
221
2054
6
10
6.03
2.70
2.8
4.5
—
—
—
0
0
171
1356
1.33
2.70
3.9
2.8
573.96
532.80
mosm/kgh2o
1.66
157
1167
206
1680
1.30
2.65
2.9
2.6
3634.64
6847.81
umol/l
0.64
181
1473
74
512
1.49
2.57
2.1
2.7
75.80
72.07
e9/l
0.41
57
387
68
463
1.51
2.55
1.3
1.2
—
—
—
0
0
34
195
1.78
2.50
1.3
1.4
278.00
297.60
ug/g
0.19
21
120
33
188
1.79
2.48
1.2
2.4
11.36
12.21
mg/l
0.23
28
173
20
96
2.11
2.44
1.3
1.3
—
53.97
—
0
7
47
299
1.61
2.38
2.1
1.8
—
—
—
0
0
14
58
2.44
2.38
1.1
1.1
—
—
—
0
0
5
8
6.28
2.37
1.2
1.0
0.83
0.02
u/ml
—
5
8
33
193
1.74
2.29
2.7
3.3
—
—
—
0
0
176
1433
1.29
2.28
1.6
1.7
471.02
21471276.75
pmol/l
1.32
150
1183
8
23
3.50
2.27
4.0
1.3
26.75
32.70
umol/l
—
8
23
109
829
1.36
2.27
7.3
5.0
1.13
1.03
mmol/l
2.71
101
762
21
106
2.01
2.27
1.1
1.2
—
—
—
0
0
75
535
1.44
2.26
3.9
3.5
128.14
77.20
ng/l
1.14
62
482
7
19
3.71
2.15
1.0
1.1
—
—
—
0
0
7
19
3.71
2.15
1.0
1.1
—
—
—
0
0
7
19
3.71
2.15
1.0
1.1
—
—
—
0
0
18
88
2.07
2.12
4.2
2.6
—
—
—
0
0
26
146
1.81
2.08
2.0
4.3
—
—
—
0
0
18
91
2.00
1.96
1.6
2.0
6.60
5.20
umol/l
0.32
12
61
16
78
2.07
1.92
1.1
1.3
—
—
nmol/l
—
0
0
275
2402
1.22
1.89
4.1
3.6
113.78
86.30
e6/l
0.30
201
1680
441
4780
0.84
1.82
3.6
3.7
—
—
—
0
0
50
348
1.46
1.75
2.5
2.8
0.16
0.17
e6/l
0.02
50
336
68
502
1.39
1.74
4.9
2.6
4.51
4.52
kpa
0.03
68
484
8
30
2.68
1.72
1.1
3.6
1140.63
815.97
u/ml
—
8
30
13
251
0.51
1.65
5.5
4.6
—
—
—
0
0
375
3409
1.18
1.61
4.1
3.7
0.00
0.00
estimate
0.50
71
685
13
63
2.08
1.60
3.0
2.7
—
—
—
0
0
15
77
1.97
1.60
1.8
2.1
—
—
—
0
0
18
99
1.84
1.58
1.3
1.8
0.61
0.83
g/l
—
10
74
148
1235
1.24
1.57
1.8
1.8
—
—
—
0
0
26
161
1.63
1.54
1.8
1.3
—
—
—
0
0
98
780
1.29
1.54
1.8
1.7
—
—
—
0
0
226
1974
1.20
1.52
3.9
3.8
11.30
8.39
mg/mmol
0.38
141
1218
31
202
1.56
1.50
1.5
2.0
36.15
38.16
g/l
0.73
26
183
374
3418
1.17
1.47
6.0
5.0
0.00
0.00
estimate
0.50
68
646
16
87
1.86
1.46
5.5
2.6
—
—
—
0
0
25
387
0.64
1.44
12.1
9.2
94.89
94.25
%
0.57
25
382
5
16
3.14
1.44
4.2
1.3
—
—
—
0
0
217
1898
1.19
1.44
4.6
3.4
—
—
—
0
0
94
752
1.28
1.43
1.6
1.5
—
—
—
0
0
7
29
2.43
1.39
1.1
2.0
3.30
8.55
nmol/l
—
7
23
16
90
1.79
1.33
1.1
1.3
0.55
0.59
nmol/l
0.22
16
83
15
83
1.82
1.32
1.1
1.2
—
—
—
0
0
6
24
2.51
1.30
1.8
1.7
—
—
—
0
0
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
15
84
1.80
1.27
1.1
1.2
—
—
—
0
0
9
44
2.06
1.27
1.2
1.3
—
—
—
0
0
31
211
1.49
1.27
1.3
1.3
—
—
—
0
0
59
451
1.33
1.26
3.4
3.0
—
—
—
0
0
14
77
1.83
1.26
1.4
1.1
—
—
—
0
0
375
3463
1.15
1.23
4.2
3.7
0.00
0.01
estimate
0.80
69
626
11
56
1.98
1.22
1.1
1.7
5.28
6.59
mmol/l
—
5
35
8
37
2.17
1.21
3.0
2.4
—
—
—
0
0
8
37
2.17
1.21
1.4
1.2
—
—
—
0
0
6
26
2.32
1.19
1.8
1.8
—
—
—
0
0
24
157
1.54
1.18
3.0
3.9
10.57
26.47
mg/l
2.63
12
96
26
174
1.51
1.16
1.4
1.1
38.57
68.57
titre
—
7
14
122
1033
1.21
1.15
1.6
1.6
—
—
—
0
0
8
152
0.52
1.15
1.6
3.4
13.50
28.41
u/ml
—
8
147
7
33
2.13
1.05
1.0
1.0
—
—
—
0
0
73
591
1.26
1.05
1.3
1.4
—
—
—
0
0
142
1231
1.19
1.05
4.5
3.7
288.41
314.25
ng/l
0.04
104
909
15
90
1.68
1.04
6.9
3.3
—
—
—
0
0
331
3060
1.14
1.03
10.9
9.1
0.00
0.00
e9/l
0.49
274
2530
12
68
1.78
1.01
1.1
1.8
—
—
—
0
0
209
1879
1.15
0.98
3.2
3.2
1313.15
406.01
mg/l
0.80
130
1188
224
2024
1.15
0.97
3.9
3.1
25.20
89.03
e6/l
1.25
187
1554
220
1986
1.15
0.97
3.7
3.8
7.40
7.40
ph
0.17
42
379
7
36
1.95
0.97
1.0
1.0
—
—
—
0
0
300
2769
1.13
0.94
3.5
3.4
6.09
5.80
ph
0.68
16
222
205
1848
1.14
0.92
4.0
3.0
0.25
0.46
e6/l
2.21
168
1398
9
52
1.74
0.92
2.0
1.2
—
—
—
0
0
67
547
1.24
0.92
3.7
3.7
1.23
1.23
mmol/l
0.02
59
477
53
661
0.79
0.91
1.4
1.3
—
—
—
0
0
120
1041
1.18
0.89
3.5
2.8
2.61
2.78
e6/l
0.11
76
564
6
30
2.01
0.87
1.2
1.2
—
—
—
0
0
6
30
2.01
0.87
1.0
1.1
—
—
—
0
0
22
308
0.71
0.84
1.0
1.1
—
—
—
0
0
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
73
609
1.22
0.84
3.3
2.3
29.25
32.67
u/l
0.40
60
514
64
528
1.23
0.82
1.9
2.4
5.20
6.30
ug/l
0.33
50
461
221
2019
1.13
0.81
3.3
3.1
6.97
7.36
mmol/l
0.75
184
1694
8
48
1.67
0.79
1.3
1.3
1.77
1.94
mmol/l
—
8
48
135
1515
0.87
0.77
3.5
4.0
1.02
1.02
kg/l
0.22
28
210
55
450
1.24
0.77
3.8
3.4
4.38
4.54
pmol/l
0.44
47
404
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
10
59
1.70
0.76
1.3
1.2
—
—
—
0
0
141
1575
0.87
0.75
3.6
3.6
—
—
—
0
0
5
24
2.09
0.74
1.0
1.2
—
—
—
0
0
6
110
0.54
0.72
1.2
1.8
—
—
—
0
0
18
126
1.44
0.70
3.3
3.2
0.75
0.90
nmol/l
0.48
13
99
19
135
1.42
0.69
4.5
3.8
57.84
58.80
%
0.13
19
135
12
77
1.57
0.69
1.2
1.1
—
—
—
0
0
7
42
1.67
0.68
1.1
1.0
293.29
300.35
mg/l
—
7
37
18
128
1.42
0.66
1.3
1.1
—
—
—
0
0
41
332
1.25
0.65
7.3
9.0
—
—
—
0
0
17
120
1.43
0.65
1.0
1.1
—
—
—
0
0
5
29
1.73
0.64
1.0
1.3
120.40
151.67
nmol/l
—
5
29
19
138
1.39
0.63
1.9
2.3
15.86
16.29
%
—
7
69
82
715
1.16
0.61
6.8
7.3
0.84
1.28
mmol/l
0.53
68
570
5
30
1.67
0.61
4.0
3.2
—
—
—
0
0
124
1114
1.13
0.61
3.4
2.6
1.33
1.06
e6/l
0.23
79
635
8
50
1.61
0.61
1.4
1.3
73.88
73.44
umol/l
—
8
50
18
131
1.38
0.59
4.2
3.5
4.54
4.34
e9/l
0.17
18
131
37
300
1.24
0.59
6.4
3.2
23.89
24.18
mmol/l
0.16
37
292
0
23
0.00
0.58
0.0
1.2
—
1.39
—
0
18
0
23
0.00
0.58
0.0
1.3
—
54.88
—
0
16
77
673
1.16
0.57
1.4
1.6
—
—
—
0
0
10
65
1.55
0.55
1.4
1.3
—
—
—
0
0
81
715
1.15
0.53
6.8
7.2
5.12
5.09
kpa
0.09
76
686
9
63
1.43
0.52
2.4
2.9
—
—
—
0
0
17
126
1.36
0.52
1.6
1.4
—
—
—
0
0
57
491
1.17
0.51
1.4
1.4
—
—
—
0
0
153
1412
1.10
0.49
3.1
2.5
6.47
7.01
e6/l
0.18
143
1267
98
883
1.12
0.48
1.3
1.2
—
—
—
0
0
11
76
1.45
0.48
1.1
1.1
—
—
—
0
0
16
120
1.34
0.46
4.9
2.3
—
—
—
0
0
16
120
1.34
0.46
1.0
1.1
—
—
—
0
0
193
1807
1.09
0.46
3.8
2.9
—
—
—
0
0
48
556
0.85
0.46
3.6
3.4
—
—
—
0
0
34
283
1.21
0.45
1.6
2.0
1.62
1.51
g/l
0.28
29
247
26
210
1.25
0.45
7.9
9.2
—
—
—
0
0
24
192
1.26
0.45
1.0
1.2
—
—
—
0
0
10
141
0.71
0.45
2.0
1.7
41.20
41.11
nmol/l
—
10
133
194
1820
1.09
0.44
1.8
1.6
1.41
1.35
mmol/l
0.37
174
1529
5
31
1.62
0.43
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
74
665
1.12
0.40
1.7
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
44.05
—
0
8
10
71
1.41
0.39
3.0
2.6
—
—
—
0
0
47
411
1.15
0.38
4.3
4.5
—
—
—
0
0
18
143
1.26
0.37
1.1
1.6
—
—
—
0
0
159
1493
1.08
0.36
4.8
5.1
2.37
2.46
ug/l
0.09
144
1335
33
384
0.85
0.35
1.3
1.2
—
—
—
0
0
17
135
1.26
0.35
2.5
3.2
2.52
2.57
mmol/l
0.03
12
91
6
43
1.40
0.35
2.3
2.9
—
—
—
0
0
48
425
1.14
0.34
3.5
2.8
48.60
50.24
u/ml
0.03
43
409
17
210
0.81
0.33
1.2
1.2
—
—
—
0
0
6
46
1.31
0.33
1.3
1.6
0.17
3.24
u/field
—
6
34
18
147
1.23
0.31
2.5
2.5
41.72
31.69
umol/l
0.64
18
129
7
53
1.32
0.31
1.1
1.2
—
—
—
0
0
7
53
1.32
0.31
1.4
1.0
—
—
—
0
0
175
1836
0.94
0.28
4.4
4.0
0.00
0.00
estimate
0.50
66
633
198
1893
1.06
0.28
1.4
1.4
—
—
—
0
0
8
64
1.25
0.27
1.6
1.6
—
—
—
0
0
12
95
1.27
0.26
1.8
1.5
—
—
—
0
0
6
83
0.72
0.24
2.0
1.9
32.00
32.33
pg
—
6
83
13
106
1.23
0.23
1.1
1.1
—
—
—
0
0
16
134
1.20
0.23
1.8
2.2
129.50
131.15
g/l
—
10
103
5
39
1.28
0.23
3.0
1.8
—
—
—
0
0
55
506
1.09
0.22
10.3
8.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
13
156
0.83
0.21
1.4
1.4
—
—
—
0
0
22
251
0.87
0.21
1.5
1.5
—
—
—
0
0
6
48
1.25
0.20
2.7
1.9
43.83
38.09
%
—
6
48
13
108
1.21
0.20
4.5
1.9
—
—
—
0
0
68
637
1.07
0.19
7.2
7.6
96.32
96.05
%
0.21
63
616
73
687
1.07
0.18
3.3
4.1
5.62
15.29
ug/l
0.88
58
562
31
280
1.11
0.18
1.1
1.1
—
—
—
0
0
13
109
1.20
0.18
1.8
1.6
—
—
—
0
0
7
59
1.19
0.18
1.7
1.3
—
—
—
0
0
53
494
1.08
0.17
3.8
2.8
197.25
187.04
ng/l
0.08
48
451
19
167
1.14
0.17
1.1
1.1
—
—
—
0
0
13
152
0.85
0.17
1.3
1.3
—
—
—
0
0
17
194
0.87
0.17
3.7
1.6
—
—
—
0
0
20
177
1.13
0.16
4.0
2.4
—
—
—
0
0
13
151
0.86
0.16
1.3
1.3
—
—
—
0
0
23
254
0.90
0.14
3.2
1.5
—
—
—
0
0
23
253
0.91
0.13
3.2
1.5
—
—
—
0
0
23
253
0.91
0.13
3.1
1.5
—
—
—
0
0
9
106
0.85
0.13
1.6
1.6
66.78
62.75
%
—
9
106
17
152
1.12
0.12
1.6
1.6
11582.80
17299.71
e6/l
—
10
114
15
168
0.89
0.11
4.3
2.0
—
—
—
0
0
122
1256
0.97
0.11
3.5
2.8
2.45
2.45
mmol/l
0.01
101
1101
5
45
1.11
0.10
1.6
1.5
—
—
—
0
0
46
439
1.05
0.09
1.3
1.4
—
—
—
0
0
6
54
1.11
0.09
1.3
1.1
—
—
—
0
0
6
55
1.09
0.09
1.5
1.1
—
—
—
0
0
6
57
1.05
0.08
1.2
1.5
1.28
1.41
nmol/l
—
6
49
5
65
0.77
0.08
2.4
2.4
—
—
—
0
0
6
72
0.83
0.07
1.2
1.9
—
—
—
0
0
6
73
0.82
0.07
1.5
1.3
—
—
—
0
0
7
82
0.85
0.07
2.0
1.5
—
—
—
0
0
9
87
1.03
0.07
1.6
2.1
—
—
—
0
0
88
859
1.03
0.06
2.6
3.1
0.75
0.74
ug/l
0.04
57
578
176
1735
1.02
0.06
7.5
6.7
—
—
—
0
0
26
247
1.05
0.05
2.2
2.5
—
—
—
0
0
28
267
1.05
0.05
2.0
2.1
19.49
3678.71
u/l
—
7
113
57
586
0.97
0.05
6.5
3.8
—
—
—
0
0
24
228
1.05
0.05
1.4
1.3
280.00
249.94
miu/ml
0.13
12
110
13
121
1.08
0.03
1.2
1.2
194.88
265.47
u/ml
—
8
69
57
558
1.02
0.03
1.3
1.2
193.55
148.46
iu/ml
0.32
22
237
14
132
1.06
0.02
3.3
2.1
—
—
—
0
0
41
418
0.98
0.01
1.7
1.7
—
—
—
0
0
15
144
1.04
0.00
2.6
1.8
—
—
—
0
0
11
114
0.96
0.00
1.3
1.5
—
—
—
0
0
21
205
1.03
0.00
1.3
1.3
—
—
—
0
0
23
235
0.98
0.00
3.1
1.5
—
—
—
0
0
32
323
0.99
0.00
8.7
9.5
23.92
24.52
mmol/l
0.61
32
315
18
178
1.01
0.00
1.2
1.3
624.89
479.35
mg/l
0.57
18
164
248
2483
1.00
0.00
3.3
2.8
—
—
—
0
0
69
691
1.00
0.00
1.3
1.4
—
—
—
0
0
10
97
1.03
0.00
1.1
1.2
—
—
—
0
0
11
111
0.99
0.00
1.0
1.1
—
—
—
0
0
13
125
1.04
0.00
1.4
1.2
—
—
—
0
0
14
135
1.04
0.00
2.8
2.9
—
—
—
0
0
6
66
0.91
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
10.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
188.80
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
326.83
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
2.8
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
17.87
—
0
7
6
60
1.00
-0.00
1.7
1.2
5.87
6.71
mmol/l
—
6
54
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.1
—
117.50
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
7.45
—
0
8
12
120
1.00
-0.00
3.7
2.3
—
—
—
0
0
7
71
0.99
-0.00
2.0
1.6
—
—
—
0
0
6
64
0.94
-0.00
1.2
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN and mortality.

Females

Parameter HR [95% CI] p-value
ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN 1.27 [1.11, 1.45] < 0.001
Birth year 0.991 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 3292 females with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.

Males

Parameter HR [95% CI] p-value
ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN 1.183 [1.01, 1.38] 0.037
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1473 males with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.

Mortality risk

Mortality risk for people of age

years, who have ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN.

N-year risk Females Males
1 0.111% 0.179%
5 0.634% 1.323%
10 1.575% 3.396%
15 3.293% 6.513%
20 5.733% 11.263%

Relationships between endpoints

Index endpoint: ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN – Allergic contact dermatitis due to drugs in contact with skin

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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