No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1235 |
4. Check minimum number of eventsNone |
1235 |
5. Include endpointsNone |
1235 |
6. Filter based on genotype QC (FinnGen only) |
1191 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E04
- Name in latin
- Struma atoxica diffusa
Similar endpoints
↥List of similar endpoints to
Nontoxic diffuse goitre
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8966 | 7514 | 1404 |
| Only index persons | 7805 | 6684 | 1121 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.04 |
| Only index persons | 0.22 | 0.25 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 54.97 | 54.35 | 58.33 |
| Only index persons | 53.79 | 53.13 | 57.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1191 | 1008 | 183 |
| Unadjusted period prevalence (%) | 0.32 | 0.36 | 0.08 |
| Median age at first event (years) | 53.09 | 52.09 | 58.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1235
- Matched controls
- 12350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
138.2
313.0
157
13
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
265.6
307.7
331
17
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
476.4
307.7
453
15
H03AA01
ATC
levothyroxine sodium; systemic
102.3
307.7
690
151
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
12635.3
307.7
1050
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
132.0
307.7
269
26
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
143.5
307.7
287
26
104
Kela drug reimbursment
Thyroid insufficiency
608.3
298.1
284
6
BAA60
NOMESCO Finland
Total thyroidectomy
883.4
230.1
219
*
H03BB01
ATC
carbimazole; oral
91.3
221.0
116
14
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
153.4
144
*
T86
ICPC
Hypothyroidism/myxoedema
82.1
144.5
77
10
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
38.6
134.1
83
23
24099
ICD-8 Finland
Simple goitre, Unspecified
+∞
126.3
119
*
E03
ICD-10 Finland
Other hypothyroidism
179.2
110.3
114
7
E03.89
ICD-10 Finland
Other specified hypothyroidism
156.9
96.7
101
7
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.4
86.4
155
272
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
83.3
79
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
13.8
77.3
73
56
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
76.9
73
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
15.0
70.3
63
44
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
152.8
68.7
72
5
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
21.7
64.0
48
23
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
24.3
55.8
40
17
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
188.0
52.4
54
*
E04.8
ICD-10 Finland
Other specified nontoxic goitre
260.3
49.4
50
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
49.3
47
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
475.0
46.6
46
*
BA1AE, ,
SPAT
12.6
39.4
39
32
2504
FHL
Unilateral resection or enucleation
70.5
36.2
41
6
E04
ICD-10 Finland
Other nontoxic goitre
82.7
36.0
40
5
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
179.9
33.9
35
*
2400A
ICD-9 Finland
Simple and unspecified goitre, Goitre, specified as simple
+∞
32.4
31
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
28.2
27
*
24010
ICD-8 Finland
Simple goitre, Sporadic
+∞
26.1
25
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
25.1
24
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
+∞
25.1
24
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
68.8
23.9
27
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
127.5
23.7
25
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.9
23.6
71
190
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
111.9
20.6
22
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
20.6
517
3563
EP1AE, ,
SPAT
5.3
19.0
38
73
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.0
18.9
86
300
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
18.8
18
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
101.6
18.6
20
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
17.7
17
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
50.8
17.0
20
*
T81
ICPC
Goitre
19.6
16.9
25
13
R06.0
ICD-10 Finland
Dyspnoea
1.8
16.9
348
2239
A11CC03
ATC
alfacalcidol; systemic
4.9
16.4
36
75
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
7.2
16.1
24
34
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
15.7
15
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
15.7
15
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
22.4
15.6
22
10
N02BE01
ATC
paracetamol; systemic, rectal
2.2
14.9
1114
9999
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
14.6
14
*
106
Kela drug reimbursment
Hypoparathyroidism
81.1
14.6
16
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.6
14.3
27
49
GB1AA
NOMESCO Finland
Tracheal X-ray examination
+∞
13.6
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
13.3
313
2068
N02AX02
ATC
tramadol; systemic, rectal
1.6
12.8
515
3872
XA402
NOMESCO Finland
ENMG
3.4
12.5
44
131
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
12.5
12
*
R13
ICD-10 Finland
Dysphagia
2.3
12.4
94
423
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
11.9
478
3575
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
11.8
279
1841
A02BC05
ATC
esomeprazole; systemic
1.5
11.7
503
3816
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
30.3
11.7
15
5
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
11.7
227
1420
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
11.5
11
*
A11CC02
ATC
dihydrotachysterol; oral
121.1
11.4
12
*
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
60.5
10.6
12
*
R01AD09
ATC
mometasone; nasal
1.5
10.6
540
4222
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
10.6
432
3225
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
10.4
10
*
R42
ICD-10 Finland
Dizziness and giddiness
1.6
10.4
290
1986
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
32.8
10.3
13
*
A02BC02
ATC
pantoprazole; systemic
1.5
10.3
828
7082
WZC30
NOMESCO Finland
Teaching
1.7
10.1
191
1183
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
10.0
160
943
R51.80
ICD-10 Finland
Headache
1.7
9.8
191
1191
N03AX16
ATC
[U] pregabalin
1.6
9.7
289
2007
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
9.6
337
2428
J01FA09
ATC
clarithromycin; systemic
1.5
9.4
370
2725
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
9.4
9
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
9.4
9
*
G44.2
ICD-10 Finland
Tension-type headache
1.7
9.3
178
1105
M01AE02
ATC
naproxen; oral, rectal
1.4
9.2
672
5577
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
9.1
328
2372
G47.3
ICD-10 Finland
Sleep apnoea
1.6
9.1
215
1411
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
4.1
9.0
24
59
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
9.0
222
1472
C07AB07
ATC
bisoprolol; oral
1.4
9.0
563
4537
UJF32
NOMESCO Finland
Coloscopy
1.5
8.9
310
2225
Z50.5
ICD-10 Finland
Speech therapy
4.5
8.9
21
47
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
8.7
347
2558
J01AA02
ATC
doxycycline; systemic
1.5
8.6
946
8441
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
8.5
127
733
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
8.5
213
1416
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
90.7
8.4
9
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
90.7
8.4
9
*
L03
ICPC
Low back symptom/complaint
1.5
8.4
334
2457
24000
ICD-8 Finland
Simple goitre, Endemic
+∞
8.3
8
*
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
+∞
8.3
8
*
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
8.3
8
*
XG466
NOMESCO Finland
Sleep oxymetry
2.9
8.3
37
128
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
8.2
345
2566
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.7
8.2
25
68
A12AA04
ATC
calcium carbonate; oral
4.4
8.2
20
46
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
8.1
63
287
J01FA06
ATC
roxithromycin; oral
1.4
8.1
477
3779
R03AC02
ATC
salbutamol; inhalant
1.4
7.9
644
5390
C08CA02
ATC
felodipine; oral
1.8
7.8
113
645
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.8
524
4238
M03BX02
ATC
tizanidine; oral
1.4
7.8
734
6291
M54.5
ICD-10 Finland
Low back pain
1.4
7.7
414
3216
XG410
NOMESCO Finland
Flow-volume spirometry
2.5
7.7
49
204
M70.6
ICD-10 Finland
Trochanteric bursitis
1.6
7.7
190
1255
T72
ICPC
Benign neoplasm thyroid
15.1
7.7
12
8
M01AH05
ATC
etoricoxib; oral
1.4
7.7
723
6189
E83.51
ICD-10 Finland
Hypocalcemia
8.9
7.6
15
17
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.5
326
2433
M01AX17
ATC
nimesulide; oral
1.5
7.5
303
2230
J01DB01
ATC
cefalexin; oral
1.5
7.5
967
8746
J01DA01
ATC
[U] cefalexin
1.4
7.4
725
6229
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
7.4
615
5145
T71
ICPC
Malignant neoplasm thyroid
+∞
7.3
7
*
BAA99
NOMESCO Finland
Other operation on thyroid gland
+∞
7.3
7
*
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
7.3
7
*
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
+∞
7.3
7
*
E06
ICD-10 Finland
Thyroiditis
+∞
7.3
7
*
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
7.3
7
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
7.3
509
4132
C07AA05
ATC
propranolol; systemic
1.5
7.3
230
1609
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.6
7.2
42
168
M79.6
ICD-10 Finland
Pain in limb
1.4
7.2
497
4027
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.2
7.2
28
90
B01AB05
ATC
enoxaparin; parenteral
1.4
7.1
377
2916
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
7.1
156
1002
A29
ICPC
General symptom/complaint other
1.7
7.0
146
925
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.0
425
3364
ZXA05
NOMESCO Finland
Left side
1.5
7.0
291
2152
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.6
7.0
151
967
R60.0
ICD-10 Finland
Localized oedema
1.7
6.9
146
928
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.9
269
1962
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.9
808
7115
R02
ICPC
Shortness of breath/dyspnoea
1.6
6.9
146
930
M79.7
ICD-10 Finland
Fibromyalgia
2.3
6.8
48
210
R51
ICD-10 Finland
Headache
2.1
6.8
64
316
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.8
270
1977
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
6.8
408
3221
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
16.8
6.7
10
6
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.8
6.7
110
652
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
12.3
6.6
11
9
Z01.2
ICD-10 Finland
Dental examination
1.4
6.5
498
4080
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.7
6.5
111
666
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.8
6.5
96
553
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.5
510
4199
M25.5
ICD-10 Finland
Pain in joint
1.4
6.4
376
2949
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.4
195
1350
ZXA00
NOMESCO Finland
Right side
1.4
6.4
311
2361
ZYC01
NOMESCO Finland
Remote contact by phone
2.0
6.4
65
331
ZYC01, ,
SPAT
1.8
6.3
97
565
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.3
699
6058
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
18.1
6.3
9
5
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
6.3
6
*
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
6.3
6
*
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
+∞
6.3
6
*
S04
ICPC
Lump/swelling localized
1.7
6.3
116
713
E06.9
ICD-10 Finland
Thyroiditis, unspecified
26.8
6.2
8
*
K08.80
ICD-10 Finland
Toothache NOS
1.8
6.2
98
575
R49.01
ICD-10 Finland
Functional dysphonia
2.4
6.2
42
181
R00.2
ICD-10 Finland
Palpitations
1.8
6.2
96
561
R49.03
ICD-10 Finland
Atrophic dysphonia
4.0
6.2
17
43
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.1
315
2414
L01
ICPC
Neck symptom/complaint
1.5
6.1
187
1297
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.9
6.1
70
372
J01FA10
ATC
azithromycin; systemic
1.3
6.1
653
5620
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.6
6.1
148
975
L28
ICPC
Limited function/disability (L)
1.5
6.0
207
1469
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
244
288
10.31
197.30
4.2
1.6
4.63
4.40
pmol/l
2.74
210
246
101
93
11.74
95.76
1.7
1.2
2.87
1.44
iu/l
1.73
29
16
64
31
21.72
85.23
4.9
1.3
391.84
57.31
u/ml
—
20
7
1092
7768
4.50
71.12
7.9
2.6
15.63
14.46
pmol/l
39.06
1032
6958
175
465
4.22
59.61
1.2
1.1
130.92
73.52
iu/ml
0.92
66
146
789
5114
2.50
51.21
6.3
5.8
1.22
1.22
mmol/l
1.43
685
4331
719
4607
2.34
45.81
6.2
5.1
1.21
1.22
mmol/l
1.20
662
4173
207
749
3.12
43.53
3.2
3.4
64.99
85.67
ng/l
4.46
174
636
96
232
4.40
36.62
1.3
1.2
—
—
—
0
0
1132
9503
3.29
32.03
9.2
3.5
1.55
1.92
mu/l
11.77
1065
8605
919
7673
1.77
16.74
4.7
4.1
12.19
12.97
mm/h
0.94
853
7068
593
4418
1.66
16.61
2.4
2.3
79.71
79.08
nmol/l
0.20
528
3963
710
5795
1.53
11.77
4.8
4.1
6.71
6.62
mmol/l
0.66
676
5418
496
3759
1.53
11.57
4.0
3.5
160.23
165.24
ng/l
0.01
335
2540
483
3649
1.53
11.38
3.3
3.4
2.35
2.36
mmol/l
1.28
420
3212
394
2867
1.55
10.92
3.0
2.8
1099.92
1269.51
ng/l
0.45
345
2438
149
850
1.86
10.37
2.3
1.9
353.42
379.42
nmol/l
0.96
138
769
277
1881
1.61
10.26
1.3
1.3
36.25
36.74
iu/ml
0.02
71
623
599
4813
1.47
10.07
2.4
2.5
—
—
—
0
0
912
7993
1.54
9.82
7.8
7.2
77.31
77.95
u/l
0.18
861
7490
344
2484
1.53
9.67
2.3
2.2
—
—
—
0
0
242
1640
1.59
8.93
2.8
2.6
1.10
1.34
e6/l
0.60
157
881
1059
9707
1.64
8.36
14.9
12.8
79.79
79.54
ml/min/173m2
0.14
917
7882
181
1163
1.65
8.25
4.5
4.7
1.03
1.05
mmol/l
0.43
164
1074
253
1780
1.53
7.83
1.4
1.2
10.31
12.05
u/ml
0.16
98
677
406
3147
1.43
7.68
2.6
2.4
56.84
87.00
u/l
0.62
367
2888
636
5367
1.38
7.16
5.6
5.8
10.20
10.96
umol/l
1.75
604
5085
334
2562
1.42
6.51
3.8
3.5
93.25
92.82
%
0.11
320
2498
350
2707
1.41
6.51
3.2
2.9
0.24
0.44
e6/l
1.67
279
2007
177
1206
1.55
6.27
1.8
2.2
97.87
105.69
ug/g
0.17
136
937
162
1082
1.57
6.26
2.5
2.5
5.25
7.59
umol/l
3.31
136
933
548
4585
1.35
6.19
15.2
14.1
1.28
1.24
inr
0.40
137
1293
56
278
2.06
5.90
1.2
1.3
1.64
5.81
u/ml
—
7
61
295
2249
1.41
5.88
1.3
1.2
0.98
1.52
u/ml
0.89
75
562
55
272
2.07
5.85
1.2
1.3
1.28
3.50
u/ml
—
6
37
1124
10629
1.64
5.82
18.0
15.2
139.97
139.66
mmol/l
4.15
1098
10325
268
2013
1.42
5.80
3.2
2.9
2.44
2.46
mmol/l
1.36
236
1786
1126
10655
1.64
5.78
18.0
15.3
3.94
3.95
mmol/l
1.00
1098
10331
111
691
1.67
5.71
2.4
2.3
10.87
19.62
au/ml
—
7
47
47
222
2.16
5.63
1.2
1.3
1.16
5.37
u/ml
—
5
22
373
2978
1.36
5.58
3.3
3.0
43.57
71.31
e6/l
0.51
303
2235
45
210
2.19
5.56
1.2
1.3
5.50
45.96
u/ml
—
8
31
13
21
6.24
5.39
1.0
1.3
—
—
—
0
0
313
2448
1.37
5.29
2.5
2.4
8741.96
6198.55
umol/l
0.34
276
2123
505
4250
1.32
5.21
2.0
2.0
95.82
95.46
pmol/l
0.05
232
2029
1086
10234
1.51
5.20
16.4
13.5
19.55
23.19
mg/l
3.70
895
8019
673
5899
1.31
5.13
9.1
8.9
3.89
4.06
e9/l
1.25
587
5125
372
3005
1.34
5.07
3.6
3.6
5.90
8.11
mg/mmol
0.75
214
1785
41
192
2.17
5.05
1.7
1.9
4.79
5.16
mmol/24h
0.29
34
167
209
1539
1.43
5.01
3.0
2.7
3.74
3.42
e6/l
0.11
128
785
1012
9431
1.40
4.96
6.3
5.5
40.46
39.49
mmol/mol
2.78
942
8695
227
1704
1.41
4.88
1.5
1.4
—
—
—
0
0
775
6952
1.31
4.85
5.3
4.6
1562.11
2778.41
e6/l
—
9
97
8
7
11.49
4.79
1.8
1.1
—
—
—
0
0
1067
10054
1.45
4.76
5.2
4.5
6.00
5.88
mmol/l
1.72
971
9100
290
2279
1.36
4.70
2.0
1.6
1.13
1.07
mg/l
0.15
220
1741
379
3101
1.32
4.67
2.1
2.0
144.55
206.72
u/l
1.33
359
2909
13
26
5.04
4.63
1.0
1.3
—
—
—
0
0
182
1325
1.44
4.63
4.6
4.4
33.58
33.35
%
0.09
123
849
208
1557
1.40
4.53
2.8
3.0
0.82
0.82
mmol/l
0.47
193
1458
60
336
1.83
4.51
2.0
1.9
—
—
—
0
0
248
1920
1.36
4.40
1.4
1.4
2.23
2.35
g/l
0.53
142
1108
363
2979
1.31
4.32
3.0
3.0
6.95
6.75
mmol/l
0.40
303
2507
349
2852
1.31
4.28
3.1
3.1
272.92
372.77
mg/l
0.18
204
1709
500
4289
1.28
4.21
2.9
2.6
110.02
110.17
ug/l
0.01
447
3965
516
4450
1.27
4.14
4.1
4.2
35.86
35.43
g/l
1.12
482
4142
34
161
2.14
4.12
1.2
1.2
16.86
13.94
u/l
0.55
26
131
552
4840
1.25
3.74
6.0
5.7
29.28
27.77
%
2.67
518
4506
51
290
1.79
3.70
1.8
1.7
—
—
—
0
0
1137
10941
1.49
3.60
11.5
10.1
23.40
24.07
u/l
1.09
1105
10538
144
1057
1.41
3.51
5.2
4.1
242.91
252.79
u/l
0.22
133
991
89
597
1.53
3.43
1.6
1.5
—
—
—
0
0
1023
9693
1.32
3.39
4.3
3.8
1.30
1.25
mmol/l
1.60
929
8785
541
4775
1.24
3.33
5.8
5.5
55.91
57.48
%
2.60
508
4438
49
285
1.75
3.32
1.5
1.4
278.69
305.60
ug/g
0.45
29
159
570
5064
1.23
3.29
4.5
3.8
0.00
0.00
estimate
0.75
107
997
77
506
1.56
3.27
5.8
7.1
24.86
24.39
mmol/l
0.80
72
493
254
2057
1.30
3.25
2.5
2.4
4.53
6.76
e6/l
3.28
229
1831
16
60
2.69
3.23
1.0
1.3
—
—
—
0
0
1082
10362
1.36
3.12
5.3
4.8
2.81
2.80
mmol/l
0.02
985
9485
54
329
1.67
3.12
3.7
3.9
24.80
24.90
mmol/l
0.08
47
297
87
595
1.50
3.09
7.2
7.1
0.70
0.69
%
0.04
87
590
48
284
1.72
3.09
1.2
1.2
—
—
—
0
0
675
6140
1.22
2.98
3.1
2.9
—
—
—
0
0
27
134
2.04
2.97
1.0
1.3
—
—
—
0
0
300
2509
1.26
2.94
2.3
2.1
3.16
3.08
mg/l
0.25
255
2129
26
128
2.05
2.93
1.0
1.3
—
—
—
0
0
27
135
2.02
2.92
1.0
1.3
—
—
—
0
0
263
2168
1.27
2.91
1.5
1.7
456.97
25084800.92
pmol/l
1.72
208
1778
26
129
2.04
2.87
1.0
1.3
—
—
—
0
0
26
129
2.04
2.87
1.0
1.3
—
—
—
0
0
86
598
1.47
2.84
7.0
7.0
1.21
1.32
%
0.71
86
593
15
59
2.56
2.79
1.0
1.3
—
—
—
0
0
5
6
8.36
2.75
1.0
1.0
4.06
6.53
nmol/l
—
5
6
1058
10139
1.30
2.72
4.8
4.3
4.73
4.79
mmol/l
1.32
969
9326
154
1197
1.33
2.65
5.9
5.6
104.25
104.17
mmol/l
0.07
154
1197
566
5103
1.20
2.62
6.0
5.2
0.00
0.00
estimate
0.50
93
932
26
134
1.96
2.61
1.0
1.3
—
—
—
0
0
571
5155
1.20
2.60
4.5
3.8
0.00
0.01
estimate
0.80
96
911
71
485
1.49
2.58
1.5
1.3
35.42
33.31
iu/l
0.19
61
423
27
142
1.92
2.57
1.3
1.2
—
0.64
nmol/l
—
0
7
1050
10074
1.28
2.52
4.7
4.3
1.50
1.56
mmol/l
5.07
957
9220
123
943
1.34
2.35
2.4
2.2
36.00
38.16
u/l
0.14
99
792
260
2196
1.23
2.30
5.2
4.2
1.01
1.02
kg/l
0.14
46
336
697
6456
1.18
2.24
2.9
2.9
42.35
45.97
u/l
0.44
647
5961
26
142
1.85
2.24
1.3
1.2
0.52
0.62
nmol/l
1.76
26
131
82
595
1.41
2.21
7.5
7.2
94.51
94.12
%
0.33
82
590
195
1608
1.25
2.15
1.9
1.8
—
—
—
0
0
25
137
1.84
2.14
1.2
1.5
0.38
0.35
nmol/l
0.17
14
105
1163
11362
1.40
2.10
24.3
19.9
40.00
39.37
%
3.05
1109
10591
111
854
1.33
2.09
3.6
3.1
2.06
2.08
mmol/l
0.01
100
720
55
376
1.48
2.04
1.3
1.3
0.28
1.43
u/ml
—
10
27
39
247
1.60
2.03
1.7
2.1
13.19
12.05
mg/l
0.45
33
227
41
264
1.57
2.00
1.7
1.9
20.85
4526.46
u/l
1.96
11
97
93
702
1.35
1.99
1.4
1.6
—
—
—
0
0
1163
11373
1.39
1.98
24.4
20.0
6.58
6.60
e9/l
0.11
1139
11012
1163
11373
1.39
1.98
24.4
19.9
257.72
257.33
e9/l
0.07
1143
11055
1163
11375
1.38
1.95
24.5
19.9
4.50
4.41
e12/l
9.39
1139
11012
29
172
1.70
1.94
1.3
1.2
—
—
—
0
0
1163
11377
1.38
1.93
24.5
20.1
134.18
132.52
g/l
4.50
1150
11192
24
135
1.79
1.92
2.1
2.3
10.60
32.77
mg/l
—
5
29
17
85
2.01
1.90
1.9
2.4
6.00
2.73
u/field
—
9
33
24
137
1.77
1.84
1.4
1.3
28.83
30.36
u/l
0.08
19
111
99
765
1.32
1.83
2.9
2.4
62.96
67.88
ml/min/173m2
0.73
47
291
9
35
2.58
1.80
1.2
1.1
—
—
—
0
0
9
35
2.58
1.80
1.2
1.1
—
—
—
0
0
144
1173
1.26
1.78
3.1
3.9
12.84
23.17
ug/l
0.48
116
945
140
1137
1.26
1.78
1.9
1.7
—
—
—
0
0
68
499
1.38
1.76
2.7
2.5
0.40
0.29
e6/l
0.36
63
480
107
841
1.30
1.76
3.6
3.5
1.22
1.23
mmol/l
1.70
97
738
15
74
2.04
1.75
1.3
1.2
—
—
—
0
0
15
74
2.04
1.75
1.3
1.2
—
—
—
0
0
154
1268
1.25
1.74
7.3
6.5
—
—
—
0
0
427
3864
1.16
1.71
4.9
4.0
—
—
—
0
0
15
75
2.01
1.70
1.3
1.2
—
—
—
0
0
15
75
2.01
1.70
1.3
1.2
—
—
—
0
0
15
75
2.01
1.70
1.3
1.2
—
—
—
0
0
139
1139
1.25
1.65
1.9
1.7
—
—
—
0
0
5
14
3.58
1.61
2.8
2.6
0.60
1.14
u/field
—
5
14
17
92
1.86
1.56
1.6
1.3
—
—
—
0
0
68
512
1.35
1.53
3.5
3.4
1.75
1.97
mmol/l
0.17
51
387
0
44
0.00
1.51
0.0
3.6
—
43.20
—
0
5
55
402
1.39
1.49
1.6
2.0
41.98
39.70
u/l
0.41
46
358
173
1471
1.20
1.46
2.6
2.2
13.35
12.81
umol/l
0.45
159
1366
7
28
2.51
1.45
3.3
1.7
8.61
97.69
u/l
—
7
28
101
813
1.26
1.42
2.3
2.3
5.09
6.09
ug/l
0.32
83
693
301
2694
1.16
1.38
5.0
4.1
0.00
0.00
estimate
1.08
99
917
87
691
1.28
1.37
3.2
3.1
1.01
0.79
ug/l
0.29
58
450
9
41
2.20
1.37
1.2
1.1
—
—
—
0
0
79
620
1.29
1.36
2.0
1.7
—
—
—
0
0
27
406
0.66
1.36
3.7
4.2
1.63
1.54
%
0.24
27
378
70
541
1.31
1.35
3.5
3.5
5.24
5.18
kpa
0.23
65
512
31
209
1.50
1.31
2.5
3.3
956.19
1807.66
u/ml
0.24
26
189
29
193
1.51
1.30
1.6
1.3
—
—
—
0
0
11
55
2.01
1.27
1.4
1.1
9.18
10.71
u/l
0.45
11
49
38
270
1.42
1.25
1.9
2.6
—
—
—
0
0
916
8841
1.14
1.23
18.5
16.3
15.57
14.97
%
1.80
907
8672
213
1874
1.17
1.23
1.8
1.7
1203.92
1179.96
nmol/l
0.12
159
1379
15
86
1.75
1.19
1.2
2.0
5.19
4.84
umol/l
—
7
57
8
38
2.11
1.18
1.6
1.5
—
—
—
0
0
8
38
2.11
1.18
1.6
1.5
—
—
—
0
0
8
38
2.11
1.18
1.6
1.5
—
—
—
0
0
10
186
0.53
1.17
1.1
1.5
—
—
—
0
0
0
36
0.00
1.14
0.0
1.8
—
2.21
—
0
19
30
208
1.45
1.13
1.5
1.4
6.80
13.61
e6/l
0.52
25
157
30
208
1.45
1.13
1.6
1.5
253.20
1949.69
e6/l
0.74
25
168
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
11
59
1.87
1.07
1.4
1.6
—
—
—
0
0
35
253
1.39
1.07
1.5
1.3
—
—
—
0
0
24
161
1.50
1.07
1.3
1.4
—
—
—
0
0
98
816
1.22
1.07
2.7
2.8
66.66
66.90
g/l
0.14
88
734
10
178
0.56
1.04
1.1
1.4
—
—
—
0
0
221
1976
1.14
1.04
4.0
3.5
279.99
323.59
ng/l
0.09
149
1518
140
1209
1.18
1.03
5.8
5.1
2.69
2.70
ug/l
0.01
124
1069
10
177
0.56
1.02
1.1
1.4
—
—
—
0
0
10
176
0.56
1.00
1.1
1.4
—
—
—
0
0
10
176
0.56
1.00
1.1
1.4
—
—
—
0
0
7
35
2.01
1.00
1.7
3.6
910.00
1020.77
u/ml
—
7
35
6
27
2.23
0.93
1.3
1.1
112.18
152.27
pmol/l
—
6
27
9
52
1.74
0.92
1.2
1.2
—
—
—
0
0
127
1101
1.17
0.91
6.0
6.0
5.12
5.11
kpa
0.05
121
1051
127
1101
1.17
0.91
6.0
5.9
12.28
12.58
kpa
0.28
121
1051
17
110
1.55
0.91
2.5
3.9
—
—
—
0
0
6
29
2.07
0.89
1.0
1.0
—
—
—
0
0
6
29
2.07
0.89
1.2
1.0
1916.00
1955.10
miu/ml
—
6
29
41
316
1.31
0.88
1.1
1.2
—
—
—
0
0
112
966
1.18
0.87
4.5
4.4
20.17
21.79
%
0.75
58
453
27
196
1.39
0.84
1.7
1.6
—
—
—
0
0
38
292
1.31
0.84
1.3
1.3
—
—
—
0
0
20
138
1.46
0.82
1.3
1.1
—
—
—
0
0
15
97
1.55
0.81
1.1
1.1
—
46.86
—
0
7
18
122
1.48
0.80
1.2
1.1
—
—
—
0
0
267
2458
1.11
0.79
1.5
1.5
20.96
21.42
nmol/l
0.19
220
2057
8
48
1.67
0.79
1.6
1.4
—
—
—
0
0
8
48
1.67
0.79
1.6
1.4
—
—
—
0
0
40
313
1.29
0.78
1.1
1.2
—
—
—
0
0
15
98
1.54
0.78
1.1
1.1
—
41.08
—
0
13
91
780
1.18
0.77
2.0
1.9
—
—
—
0
0
33
253
1.31
0.75
1.6
1.6
9527.16
11269.64
e6/l
0.19
25
188
33
253
1.31
0.75
1.2
1.1
—
—
—
0
0
18
124
1.46
0.75
1.1
1.1
10.49
3.23
u/ml
0.43
11
58
9
54
1.67
0.74
1.2
1.2
—
—
—
0
0
82
700
1.18
0.74
1.9
1.8
—
—
—
0
0
152
1360
1.13
0.74
2.7
2.2
2.35
2.35
g/l
0.00
139
1256
14
92
1.53
0.72
1.1
1.1
—
2.17
—
0
6
141
1259
1.14
0.71
2.8
2.3
22.79
22.30
%
0.16
125
1078
22
298
0.73
0.71
1.2
1.4
—
—
—
0
0
40
318
1.27
0.71
3.7
2.1
38.47
37.84
g/l
0.33
35
280
31
399
0.77
0.71
1.4
1.5
—
—
—
0
0
121
1070
1.15
0.71
2.6
2.5
1.69
1.84
%
1.17
96
938
5
26
1.93
0.70
4.2
1.4
122.60
61.00
nmol/24h
—
5
26
9
58
1.56
0.70
1.0
1.0
—
—
—
0
0
12
77
1.56
0.68
1.5
1.3
—
—
—
0
0
12
77
1.56
0.68
1.5
1.3
—
—
—
0
0
12
77
1.56
0.68
1.5
1.3
—
—
—
0
0
123
1093
1.14
0.67
6.1
6.0
1.33
1.16
mmol/l
0.20
106
870
28
214
1.32
0.67
1.3
1.3
—
—
—
0
0
28
214
1.32
0.67
1.3
1.3
—
—
—
0
0
5
28
1.79
0.66
1.6
2.1
—
—
—
0
0
11
70
1.58
0.65
1.7
1.6
—
—
—
0
0
44
359
1.23
0.64
1.6
1.9
0.73
2.08
ug/l
0.95
39
314
27
207
1.31
0.64
1.7
2.1
134.41
127.49
g/l
0.65
17
147
45
369
1.23
0.63
1.5
1.8
—
—
—
0
0
13
87
1.50
0.63
1.0
1.2
—
—
—
0
0
19
138
1.38
0.62
1.1
1.0
2.70
1.88
u/ml
—
9
61
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
29
227
1.28
0.60
2.3
1.4
—
—
—
0
0
8
53
1.51
0.58
1.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
40
329
1.22
0.56
6.3
4.0
1.29
1.36
mmol/l
0.29
40
323
49
412
1.20
0.56
3.2
3.0
104.81
957.23
u/ml
1.24
37
353
27
214
1.27
0.52
1.4
1.2
3.55
3.80
mmol/l
1.07
27
201
28
223
1.26
0.52
1.3
1.4
—
—
—
0
0
19
143
1.33
0.52
1.1
1.1
0.11
2.13
u/ml
—
10
74
16
117
1.37
0.52
2.6
2.4
—
360.22
—
0
9
6
98
0.61
0.52
1.0
1.2
—
—
—
0
0
233
2184
1.08
0.50
1.3
1.4
—
—
—
0
0
29
234
1.25
0.49
1.1
1.3
—
—
—
0
0
10
144
0.69
0.49
1.1
1.5
—
—
—
0
0
261
2766
0.93
0.49
1.7
1.6
1.33
1.34
mmol/l
0.06
213
2364
20
154
1.30
0.48
1.4
1.3
—
—
—
0
0
20
154
1.30
0.48
1.4
1.3
—
—
—
0
0
13
93
1.40
0.48
1.1
1.1
—
—
—
0
0
18
138
1.31
0.45
1.3
1.1
2.13
2.20
u/ml
—
8
45
8
58
1.38
0.41
1.3
1.1
204.38
268.92
mg/l
—
8
48
46
398
1.16
0.41
1.9
1.9
—
—
—
0
0
112
1027
1.10
0.41
3.0
3.3
—
—
—
0
0
5
34
1.47
0.40
3.8
4.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
9
66
1.37
0.38
1.0
1.1
—
—
—
0
0
25
206
1.22
0.38
1.8
1.6
—
—
—
0
0
18
143
1.26
0.37
1.8
1.6
—
—
—
0
0
18
224
0.80
0.37
2.3
2.7
25.96
25.15
mmol/l
0.30
18
218
24
198
1.22
0.36
2.0
3.4
57.88
58.57
%
0.09
24
198
9
71
1.27
0.36
2.1
1.8
—
—
—
0
0
17
135
1.26
0.35
1.6
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
283
1.17
0.34
2.0
2.5
0.33
0.38
u/ml
0.36
19
155
6
44
1.37
0.34
1.0
1.0
—
—
—
0
0
28
237
1.19
0.34
1.5
1.2
—
—
—
0
0
7
53
1.32
0.31
1.0
1.5
1.45
1.59
g/l
—
7
53
7
53
1.32
0.31
1.0
1.0
—
—
—
0
0
26
221
1.18
0.30
1.3
1.4
—
—
—
0
0
17
138
1.24
0.30
1.4
1.1
1.38
1.62
u/ml
—
8
37
17
207
0.82
0.30
1.2
1.4
—
—
—
0
0
101
939
1.08
0.30
2.2
2.0
0.21
0.21
g/l
0.02
93
894
16
196
0.81
0.30
2.7
2.3
16.27
16.09
%
0.06
11
88
12
93
1.29
0.30
1.5
1.3
—
—
—
0
0
41
364
1.13
0.29
1.5
1.6
—
—
—
0
0
27
232
1.17
0.28
2.5
2.7
1.80
1.50
mg/l
0.58
22
210
42
374
1.13
0.28
3.5
2.3
9.12
10.01
g/l
1.22
37
334
71
772
0.91
0.28
1.7
1.7
—
—
—
0
0
13
103
1.26
0.28
1.1
1.5
—
—
—
0
0
43
478
0.90
0.26
1.2
1.4
—
—
—
0
0
157
1494
1.06
0.25
2.2
1.9
30.47
29.43
s
0.59
151
1441
14
170
0.82
0.25
1.3
1.3
—
—
—
0
0
9
77
1.17
0.24
1.0
1.0
—
—
—
0
0
15
124
1.21
0.24
1.1
1.4
—
—
—
0
0
333
3237
1.04
0.23
3.0
3.0
28.15
33.96
u/l
1.35
318
3085
5
38
1.32
0.23
1.2
1.1
91.80
98.03
%
—
5
32
51
468
1.09
0.22
1.7
1.7
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
5
42
1.19
0.21
1.0
1.2
—
82.33
—
0
6
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
2.0
1.3
—
—
—
0
0
5
43
1.16
0.21
2.0
1.3
—
—
—
0
0
26
293
0.88
0.21
1.4
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
5.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
1.27
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.0
1.1
—
—
—
0
0
10
122
0.82
0.19
1.2
1.3
—
—
—
0
0
40
367
1.09
0.18
1.3
1.7
2.11
4.42
mg/l
0.92
33
284
11
91
1.21
0.17
1.9
2.3
—
—
—
0
0
13
110
1.18
0.17
7.8
5.6
12.61
12.15
mg/l
0.15
13
101
58
545
1.07
0.16
1.1
1.0
—
—
—
0
0
6
79
0.76
0.15
1.5
1.3
—
—
—
0
0
55
518
1.06
0.14
1.2
1.4
—
—
—
0
0
15
131
1.15
0.14
1.3
1.5
49.75
59.10
%
—
8
79
22
243
0.90
0.14
4.0
3.6
22.75
25.82
mg/l
0.12
13
144
9
110
0.82
0.13
4.3
2.4
13.41
13.29
%
—
9
110
12
137
0.87
0.12
1.8
1.4
—
116.87
—
0
32
13
147
0.88
0.11
1.3
1.3
—
—
—
0
0
31
290
1.07
0.10
1.5
1.5
0.03
0.10
iu/ml
0.83
13
61
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
45
1.11
0.10
1.0
1.1
—
—
—
0
0
12
106
1.13
0.09
1.3
1.3
—
—
—
0
0
12
106
1.13
0.09
1.3
1.3
—
—
—
0
0
5
47
1.06
0.09
2.4
2.6
—
—
—
0
0
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
7
64
1.09
0.08
1.0
1.4
—
—
—
0
0
10
88
1.14
0.08
1.6
1.3
—
—
—
0
0
7
65
1.08
0.08
1.7
1.4
72.14
79.92
umol/l
—
7
65
42
401
1.05
0.08
3.6
2.3
3.47
3.57
g/l
0.34
37
363
42
401
1.05
0.08
3.6
2.3
—
—
—
0
0
8
76
1.05
0.07
1.1
1.5
—
—
—
0
0
15
138
1.09
0.06
1.1
1.1
—
—
—
0
0
9
101
0.89
0.06
2.8
2.1
—
—
—
0
0
93
950
0.98
0.05
1.3
1.7
1.41
1.43
%
0.06
77
826
23
218
1.06
0.05
3.8
3.1
0.86
0.84
nmol/l
0.06
17
172
31
299
1.04
0.03
3.4
3.3
29.61
84.59
mg/l
1.42
26
238
27
280
0.96
0.03
1.1
1.3
203.40
237.82
miu/ml
—
10
130
29
280
1.04
0.03
1.6
1.7
—
—
—
0
0
11
116
0.95
0.00
1.8
1.6
—
—
—
0
0
14
146
0.96
0.00
1.1
1.2
—
—
—
0
0
22
214
1.03
0.00
1.9
2.3
78.67
81.90
ug/min
—
9
122
13
126
1.03
0.00
1.1
1.1
—
—
—
0
0
16
159
1.01
0.00
1.2
1.3
—
—
—
0
0
30
301
1.00
0.00
3.4
3.3
24.55
40.41
mg/l
0.86
24
240
10
97
1.03
0.00
1.2
1.4
—
—
—
0
0
13
127
1.02
0.00
1.2
1.3
—
—
—
0
0
5
53
0.94
0.00
1.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
22.49
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
6.95
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
37.30
—
0
7
13
130
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
9.01
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.6
2.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITREDIFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREDIFF | 1.08 [0.97, 1.2] | 0.166 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 753 out of 4980 females with E4_GOITREDIFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREDIFF | 1.199 [1.0, 1.44] | 0.05 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 886 males with E4_GOITREDIFF died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITREDIFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.187% |
| 5 | 0.582% | 1.244% |
| 10 | 1.489% | 3.239% |
| 15 | 2.926% | 5.961% |
| 20 | 5.264% | 10.079% |
Relationships between endpoints
↥Index endpoint: E4_GOITREDIFF – Nontoxic diffuse goitre
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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