No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1189 |
4. Check minimum number of eventsNone |
1189 |
5. Include endpointsNone |
1189 |
6. Filter based on genotype QC (FinnGen only) |
1189 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E04
- Name in latin
- Struma atoxica diffusa
Similar endpoints
↥List of similar endpoints to
Nontoxic diffuse goitre
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8966 | 7514 | 1404 |
| Only index persons | 7805 | 6684 | 1121 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.04 |
| Only index persons | 0.22 | 0.25 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 54.97 | 54.35 | 58.33 |
| Only index persons | 53.79 | 53.13 | 57.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1189 | 1003 | 186 |
| Unadjusted period prevalence (%) | 0.30 | 0.34 | 0.08 |
| Median age at first event (years) | 52.77 | 51.70 | 58.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1045
- Matched controls
- 10450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
298.0
323.0
368
19
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
4503599627370496.0
323.0
871
*
H03AA01
ATC
levothyroxine sodium; systemic
92.4
323.0
571
134
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
279.3
274.8
270
13
104
Kela drug reimbursment
Thyroid insufficiency
616.4
252.1
240
5
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
130.1
206.4
217
21
BAA60
NOMESCO Finland
Total thyroidectomy
2234.4
188.4
177
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
101.5
176.4
191
23
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
162.6
136.0
141
10
24099
ICD-8 Finland
Simple goitre, Unspecified
+∞
120.2
113
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
580.0
107.8
105
*
H03BB01
ATC
carbimazole; oral
104.4
87.6
95
10
E03
ICD-10 Finland
Other hypothyroidism
57.0
75.5
89
17
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
69.6
66
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
245.9
68.1
69
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
178.7
64.8
67
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
326.1
61.0
61
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
44.0
53.5
66
16
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.0
49.6
130
209
T86
ICPC
Hypothyroidism/myxoedema
56.8
46.0
54
10
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
467.1
45.6
45
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
44.1
42
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
43.0
41
*
E04.8
ICD-10 Finland
Other specified nontoxic goitre
81.0
35.1
39
5
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
19.2
34.7
53
29
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
+∞
34.6
33
*
2504
FHL
Unilateral resection or enucleation
337.2
33.1
33
*
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
54.7
31.5
37
7
2400A
ICD-9 Finland
Simple and unspecified goitre, Goitre, specified as simple
+∞
30.4
29
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
11.1
30.3
58
55
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
27.2
26
*
E04
ICD-10 Finland
Other nontoxic goitre
53.1
26.3
31
6
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
22.6
24.4
35
16
24010
ICD-8 Finland
Simple goitre, Sporadic
+∞
23.0
22
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
122.7
22.7
24
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
20.9
20
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
19.8
19
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
203.6
19.6
20
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
+∞
18.8
18
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
193.3
18.6
19
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
96.7
17.6
19
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
91.5
16.6
18
*
T81
ICPC
Goitre
86.4
15.6
17
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.4
14.7
73
227
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
13.6
13
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
13.6
13
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
141.7
13.5
14
*
106
Kela drug reimbursment
Hypoparathyroidism
131.5
12.5
13
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
13.4
12.5
21
16
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
11.7
276
1801
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
11.5
11
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
11.5
11
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
8.0
11.4
25
32
N02BE01
ATC
paracetamol; systemic, rectal
1.8
11.2
897
8040
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
60.6
10.6
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.6
217
1349
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
10.5
386
2822
A11CC03
ATC
alfacalcidol; systemic
5.7
10.5
29
52
GB1AA
NOMESCO Finland
Tracheal X-ray examination
111.1
10.4
11
*
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
10.4
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
9.4
181
1101
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
9.4
9
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.3
221
1429
BA1AE
SPAT
NA
10.8
9.3
17
16
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.2
382
2853
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.9
246
1659
R13
ICD-10 Finland
Dysphagia
2.5
8.8
69
288
XA402
NOMESCO Finland
ENMG
3.9
8.8
35
93
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
7.3
8.8
20
28
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.1
8.7
46
153
M01AE02
ATC
naproxen; oral, rectal
1.5
8.6
560
4587
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
+∞
8.3
8
*
24000
ICD-8 Finland
Simple goitre, Endemic
+∞
8.3
8
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
8.3
8
*
A11CC02
ATC
dihydrotachysterol; oral
33.6
8.1
10
*
L03
ICPC
Low back symptom/complaint
1.6
8.0
239
1644
A02BC02
ATC
pantoprazole; systemic
1.5
7.8
644
5489
A03FA02
ATC
cisapride; oral, rectal
2.1
7.6
85
424
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
7.5
294
2148
A02BC05
ATC
esomeprazole; systemic
1.5
7.5
397
3092
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
80.6
7.4
8
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
6.0
7.4
19
32
E83.51
ICD-10 Finland
Hypocalcemia
13.5
7.4
12
9
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
7.3
7
*
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
+∞
7.3
7
*
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.2
402
3156
C07AB07
ATC
bisoprolol; oral
1.4
7.2
440
3515
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.1
123
721
M01AX17
ATC
nimesulide; oral
1.5
7.1
254
1810
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
20.2
7.1
10
5
N03AX16
ATC
pregabalin; oral
1.5
7.1
234
1642
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.7
515
4273
R00.2
ICD-10 Finland
Palpitations
2.1
6.6
75
376
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.6
338
2597
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
6.5
44
173
E06
ICD-10 Finland
Thyroiditis
70.2
6.4
7
*
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.3
135
843
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
6.3
162
1066
ZXA00
NOMESCO Finland
Right side
1.5
6.3
272
2018
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
+∞
6.3
6
*
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
+∞
6.3
6
*
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
6.3
6
*
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
6.3
6
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
6.3
6
*
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
6.3
6
*
BAA30
NOMESCO Finland
Excision of thyroid isthmus
+∞
6.3
6
*
UJC01
NOMESCO Finland
Scopy of lower throat
6.3
6.2
15
24
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.1
445
3632
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.0
113
679
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
226
301
9.04
165.38
4.3
1.7
4.6
4.5
pmol/l
1.38
194
258
63
32
20.73
82.21
5.0
1.3
411.8
57.3
u/ml
—
19
7
93
104
9.62
76.71
1.8
1.2
3.0
2.3
iu/l
0.28
28
16
1048
7497
4.36
66.33
8.0
2.6
15.7
14.5
pmol/l
41.92
989
6721
758
4944
2.47
47.99
6.3
5.8
1.2
1.2
mmol/l
1.34
655
4165
160
477
3.72
46.01
1.2
1.2
105.1
79.0
iu/ml
0.36
61
158
689
4448
2.31
42.57
6.3
5.1
1.2
1.2
mmol/l
1.10
629
4003
202
732
3.12
42.42
3.2
3.3
65.2
86.1
ng/l
4.41
170
624
90
224
4.26
33.04
1.3
1.2
—
—
—
0
0
1083
9126
3.09
29.12
9.2
3.5
1.6
1.9
mu/l
11.41
1018
8265
572
4249
1.67
16.35
2.4
2.3
79.8
79.1
nmol/l
0.21
507
3815
878
7402
1.71
14.46
4.7
4.1
12.2
13.0
mm/h
0.95
813
6825
211
1219
1.89
14.37
18.7
23.3
1.2
1.3
inr
0.10
22
167
479
3645
1.53
10.92
3.9
3.6
167.1
169.7
ng/l
0.00
320
2465
467
3541
1.53
10.80
3.3
3.4
2.4
2.4
mmol/l
1.30
399
3096
266
1798
1.62
10.08
1.3
1.3
36.8
36.1
iu/ml
0.03
69
582
676
5584
1.49
10.03
4.9
4.2
6.7
6.6
mmol/l
0.71
641
5218
334
2389
1.55
9.92
2.3
2.2
—
—
—
0
0
881
7699
1.56
9.91
7.7
7.2
77.4
78.0
u/l
0.15
827
7208
379
2789
1.53
9.88
3.1
2.8
1120.0
1265.1
ng/l
0.36
331
2377
577
4644
1.47
9.60
3.6
3.9
—
—
—
0
0
138
824
1.76
8.26
2.3
1.9
359.9
381.7
nmol/l
0.72
127
746
1017
9323
1.63
7.97
14.9
12.8
79.6
79.3
ml/min/173m2
0.16
877
7574
392
3024
1.44
7.68
2.6
2.3
57.2
58.0
u/l
0.13
354
2774
174
1133
1.63
7.53
4.6
4.5
1.0
1.0
mmol/l
0.49
158
1053
242
1713
1.52
7.27
1.4
1.2
10.5
11.5
u/ml
0.09
94
650
227
1586
1.53
7.25
2.8
2.6
1.1
1.3
e6/l
0.69
150
851
613
5178
1.38
6.86
5.6
5.9
10.2
11.0
umol/l
1.81
581
4901
107
661
1.68
5.68
2.4
2.4
7.2
15.4
au/ml
—
6
26
259
1945
1.42
5.64
3.2
2.9
2.4
2.5
mmol/l
1.32
228
1731
281
2153
1.40
5.43
1.3
1.2
1.0
1.6
u/ml
1.02
73
546
167
1160
1.51
5.42
1.9
2.1
106.1
103.3
ug/g
0.05
125
896
1082
10263
1.60
5.16
18.1
15.4
3.9
4.0
mmol/l
0.96
1054
9955
1080
10240
1.60
5.16
18.1
15.3
140.0
139.7
mmol/l
3.88
1054
9950
152
1049
1.51
5.08
2.6
2.5
5.1
7.5
umol/l
3.41
127
906
486
4094
1.32
4.98
2.0
2.0
95.2
95.3
pmol/l
0.02
219
1962
178
1282
1.46
4.82
4.6
4.4
33.4
33.3
%
0.05
118
820
10
20
5.03
4.78
1.0
1.3
—
—
—
0
0
326
2619
1.34
4.59
3.2
2.9
0.3
0.4
e6/l
1.48
257
1927
51
270
1.93
4.56
1.2
1.3
1.6
5.6
u/ml
—
7
59
201
1496
1.41
4.54
2.8
3.0
0.8
0.8
mmol/l
0.33
185
1395
43
215
2.04
4.51
1.1
1.2
1.2
5.8
u/ml
—
5
20
50
264
1.93
4.50
1.2
1.3
1.3
3.6
u/ml
—
6
36
297
2364
1.34
4.43
2.5
2.4
9261.0
6635.9
umol/l
0.33
260
2030
1042
9865
1.46
4.35
16.5
13.4
19.6
23.2
mg/l
3.44
856
7728
642
5679
1.28
4.33
9.3
8.8
3.9
4.1
e9/l
1.10
561
4935
277
2199
1.34
4.18
2.0
1.6
1.1
1.1
mg/l
0.21
209
1691
40
203
2.00
4.06
1.2
1.3
5.3
44.7
u/ml
—
7
32
970
9099
1.36
4.04
6.3
5.5
40.5
39.5
mmol/mol
2.82
901
8395
210
1607
1.37
4.01
1.5
1.4
—
—
—
0
0
353
2915
1.30
4.00
3.8
3.8
6.2
8.2
mg/mmol
0.62
203
1733
1024
9693
1.41
4.00
5.2
4.5
6.0
5.9
mmol/l
1.55
931
8785
196
1487
1.38
3.95
3.0
2.7
3.1
3.5
e6/l
0.14
123
757
57
329
1.77
3.92
2.1
2.0
—
—
—
0
0
361
3001
1.29
3.87
2.1
2.1
147.9
209.4
u/l
1.24
342
2816
739
6702
1.27
3.86
5.3
4.6
1562.1
3492.0
e6/l
—
9
97
88
577
1.57
3.74
1.4
1.5
—
—
—
0
0
77
491
1.61
3.68
5.8
7.4
24.8
24.4
mmol/l
0.71
70
459
345
2880
1.28
3.53
3.0
3.0
6.9
6.7
mmol/l
0.41
288
2412
10
26
3.87
3.52
1.0
1.3
—
—
—
0
0
139
1020
1.41
3.41
5.3
4.1
243.2
254.0
u/l
0.24
128
959
493
4310
1.25
3.37
4.1
4.2
35.9
35.4
g/l
1.19
458
4012
31
154
2.04
3.37
1.2
1.2
17.2
14.6
u/l
0.46
25
124
53
316
1.71
3.30
3.7
3.8
24.8
24.9
mmol/l
0.03
46
288
27
129
2.12
3.25
1.0
1.3
—
—
—
0
0
47
273
1.75
3.22
1.6
1.4
272.9
303.9
ug/g
0.53
28
151
47
273
1.75
3.22
1.2
1.2
—
—
—
0
0
26
123
2.14
3.21
1.0
1.3
—
—
—
0
0
27
130
2.10
3.20
1.0
1.3
—
—
—
0
0
471
4119
1.24
3.16
3.0
2.6
111.9
110.2
ug/l
0.06
419
3807
26
124
2.12
3.15
1.0
1.3
—
—
—
0
0
26
124
2.12
3.15
1.0
1.3
—
—
—
0
0
85
578
1.51
3.11
7.3
7.4
0.7
0.7
%
0.03
85
573
1091
10527
1.44
3.04
11.5
10.2
23.4
24.0
u/l
1.00
1059
10143
26
129
2.04
2.87
1.0
1.3
—
—
—
0
0
256
2109
1.27
2.86
1.5
1.7
460.3
18775709.0
pmol/l
1.57
203
1731
983
9356
1.29
2.84
4.3
3.8
1.3
1.3
mmol/l
1.65
890
8487
84
582
1.48
2.83
7.2
7.2
1.2
1.3
%
0.82
84
577
5
6
8.36
2.75
1.6
1.0
—
—
—
0
0
46
279
1.67
2.74
1.8
1.7
—
—
—
0
0
1039
9993
1.31
2.54
5.3
4.8
2.8
2.8
mmol/l
0.09
944
9143
641
5868
1.20
2.52
3.1
2.8
—
—
—
0
0
283
2406
1.23
2.38
2.3
2.1
3.2
3.1
mg/l
0.52
238
2040
539
4880
1.19
2.33
4.5
3.8
0.0
0.0
estimate
0.00
88
881
190
1548
1.27
2.32
1.9
1.8
—
—
—
0
0
17
79
2.17
2.25
1.8
2.5
6.0
2.5
u/field
—
9
28
80
577
1.41
2.23
7.7
7.5
94.6
94.1
%
0.44
80
572
1015
9778
1.26
2.12
4.8
4.3
4.7
4.8
mmol/l
1.02
928
8988
251
2135
1.22
2.09
5.2
4.2
1.0
1.0
kg/l
0.15
45
324
90
673
1.36
2.05
1.3
1.5
—
—
—
0
0
24
132
1.84
2.04
2.1
2.3
10.6
30.5
mg/l
—
5
32
24
133
1.82
2.00
1.2
1.4
0.4
0.3
nmol/l
0.61
14
103
235
1996
1.22
1.98
2.5
2.4
4.7
7.2
e6/l
2.79
204
1738
24
134
1.81
1.96
1.4
1.3
28.8
31.3
u/l
0.14
19
107
65
464
1.42
1.95
1.5
1.3
36.5
33.6
iu/l
0.27
56
402
5
11
4.56
1.94
2.8
2.9
0.6
1.2
u/field
—
5
11
137
1100
1.28
1.91
1.9
1.7
—
—
—
0
0
1007
9718
1.24
1.90
4.7
4.3
1.5
1.6
mmol/l
4.78
915
8891
9
34
2.66
1.86
1.2
1.1
—
—
—
0
0
9
34
2.66
1.86
1.2
1.1
—
—
—
0
0
666
6210
1.16
1.86
2.9
2.9
42.9
46.2
u/l
0.37
615
5739
107
835
1.31
1.85
3.6
3.1
2.0
2.1
mmol/l
0.05
90
675
28
167
1.69
1.85
1.3
1.2
—
—
—
0
0
115
907
1.30
1.84
2.5
2.1
31.0
38.2
u/l
1.40
92
761
136
1100
1.27
1.79
1.9
1.7
—
—
—
0
0
13
60
2.18
1.78
1.0
1.3
—
—
—
0
0
52
364
1.45
1.75
1.4
1.3
0.3
1.4
u/ml
—
10
27
150
1235
1.25
1.71
7.3
6.6
—
—
—
0
0
36
235
1.55
1.69
1.7
2.1
13.0
12.2
mg/l
0.26
30
216
139
1136
1.25
1.69
3.1
4.0
11.0
15.0
ug/l
0.26
112
917
37
244
1.53
1.67
1.6
1.9
22.8
4313.6
u/l
—
10
93
535
4936
1.15
1.66
6.1
5.2
0.0
0.0
estimate
0.50
85
886
17
90
1.90
1.65
1.6
1.3
—
—
—
0
0
540
4986
1.15
1.65
4.6
3.8
0.0
0.0
estimate
0.80
88
864
1117
10946
1.34
1.62
24.5
20.0
257.8
257.0
e9/l
0.14
1097
10638
1117
10948
1.33
1.60
24.5
20.0
4.5
4.4
e12/l
8.44
1093
10600
1117
10949
1.33
1.59
24.5
20.0
6.6
6.6
e9/l
0.08
1093
10603
1117
10950
1.33
1.58
24.6
20.1
134.2
132.5
g/l
4.25
1104
10771
25
396
0.62
1.56
3.4
4.2
1.7
1.6
%
0.28
25
369
23
137
1.69
1.56
1.2
1.2
0.5
0.6
nmol/l
1.68
23
127
95
749
1.29
1.56
2.8
2.4
63.2
67.8
ml/min/173m2
0.64
45
287
0
43
0.00
1.52
0.0
3.6
—
43.2
—
0
5
77
592
1.32
1.52
2.0
1.7
—
—
—
0
0
66
496
1.35
1.51
3.5
3.4
1.7
1.9
mmol/l
0.11
48
375
37
251
1.49
1.49
1.7
1.4
387.0
301.3
mu/l
0.54
32
225
20
117
1.72
1.45
1.2
1.3
214.1
278.0
pmol/l
1.01
15
89
11
52
2.13
1.44
1.4
1.1
9.2
10.7
u/l
0.45
11
47
7
29
2.42
1.39
3.3
1.7
8.6
94.5
u/l
—
7
29
30
198
1.53
1.38
1.6
1.5
253.2
1891.4
e6/l
0.67
25
162
30
198
1.53
1.38
1.5
1.5
6.8
14.0
e6/l
0.55
25
151
12
60
2.01
1.38
1.0
1.3
—
—
—
0
0
408
3733
1.14
1.37
5.0
4.0
—
—
—
0
0
68
523
1.32
1.36
3.5
3.4
5.3
5.2
kpa
0.49
61
480
98
791
1.26
1.36
2.2
2.3
5.2
5.9
ug/l
0.20
79
680
28
183
1.54
1.35
1.6
1.3
—
—
—
0
0
86
685
1.28
1.33
3.2
3.1
1.0
0.8
ug/l
0.29
57
447
37
260
1.44
1.28
1.8
2.6
—
—
—
0
0
206
1806
1.17
1.25
1.8
1.7
1207.0
1187.5
nmol/l
0.09
153
1329
8
36
2.23
1.24
1.6
1.5
—
—
—
0
0
8
36
2.23
1.24
1.6
1.5
—
—
—
0
0
8
36
2.23
1.24
1.8
1.5
—
—
—
0
0
8
36
2.23
1.24
1.3
1.1
—
—
—
0
0
99
813
1.24
1.20
3.5
3.6
1.2
1.2
mmol/l
1.79
89
717
13
71
1.84
1.19
1.3
1.2
—
—
—
0
0
13
71
1.84
1.19
1.3
1.2
—
—
—
0
0
9
169
0.53
1.19
1.1
1.5
—
—
—
0
0
51
385
1.34
1.18
1.7
2.0
41.7
39.3
u/l
0.41
42
341
13
72
1.81
1.15
1.3
1.2
—
—
—
0
0
13
72
1.81
1.15
1.3
1.2
—
—
—
0
0
13
72
1.81
1.15
1.3
1.2
—
—
—
0
0
29
199
1.47
1.15
2.6
3.4
1035.2
1897.3
u/ml
0.22
24
180
0
35
0.00
1.15
0.0
1.8
—
2.3
—
0
18
163
1416
1.18
1.11
2.7
2.2
13.3
12.7
umol/l
0.47
147
1303
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
9
162
0.55
1.09
1.1
1.4
—
—
—
0
0
9
162
0.55
1.09
1.1
1.4
—
—
—
0
0
34
244
1.41
1.08
1.4
1.4
—
—
—
0
0
23
153
1.51
1.06
1.3
1.5
—
—
—
0
0
17
105
1.63
1.06
2.5
3.8
—
—
—
0
0
17
105
1.63
1.06
1.2
1.1
60.5
53.7
u/l
0.17
11
74
9
49
1.84
0.98
1.2
1.2
—
—
—
0
0
9
161
0.56
0.98
1.1
1.4
—
—
—
0
0
9
161
0.56
0.98
1.1
1.4
—
—
—
0
0
285
2604
1.12
0.96
5.1
4.1
0.0
0.0
estimate
1.08
91
870
124
1069
1.18
0.95
6.0
6.1
5.1
5.1
kpa
0.03
118
1021
9
51
1.77
0.94
1.2
1.2
—
—
—
0
0
124
1070
1.18
0.94
6.0
6.1
12.4
12.6
kpa
0.19
118
1022
137
1193
1.17
0.93
5.8
5.1
2.7
2.7
ug/l
0.02
121
1054
212
1906
1.14
0.93
4.1
3.5
291.4
328.1
ng/l
0.07
143
1470
6
28
2.15
0.91
1.0
1.0
—
—
—
0
0
45
349
1.30
0.91
1.5
1.8
—
—
—
0
0
15
94
1.60
0.90
1.1
1.1
—
46.9
—
0
7
94
795
1.20
0.90
2.8
2.8
66.6
67.0
g/l
0.23
84
721
26
185
1.41
0.90
1.7
1.7
—
—
—
0
0
111
955
1.18
0.88
4.5
4.4
20.0
21.9
%
0.90
57
452
15
95
1.59
0.87
1.1
1.1
—
41.1
—
0
13
8
45
1.78
0.84
1.6
1.4
—
—
—
0
0
8
45
1.78
0.84
1.6
1.4
—
—
—
0
0
8
45
1.78
0.84
1.6
1.4
—
—
—
0
0
8
45
1.78
0.84
1.6
1.4
—
—
—
0
0
10
57
1.76
0.83
1.4
1.6
—
—
—
0
0
8
46
1.74
0.82
1.0
1.1
—
—
—
0
0
14
89
1.58
0.81
1.1
1.1
—
2.0
—
0
5
246
2674
0.90
0.78
1.7
1.6
1.3
1.3
mmol/l
0.13
202
2286
6
34
1.77
0.76
1.8
3.7
1009.0
1040.1
u/ml
—
6
34
11
67
1.65
0.75
1.7
1.6
—
—
—
0
0
32
245
1.31
0.74
1.1
1.1
—
—
—
0
0
29
219
1.33
0.73
2.3
1.5
—
—
—
0
0
27
203
1.34
0.71
1.4
1.2
3.5
3.8
mmol/l
1.16
27
192
44
355
1.25
0.70
1.6
1.8
0.7
2.1
ug/l
0.96
39
311
19
135
1.41
0.69
1.3
1.1
—
—
—
0
0
120
1063
1.14
0.69
6.1
6.1
1.3
1.2
mmol/l
0.12
103
835
256
2371
1.10
0.69
1.5
1.5
20.9
21.5
nmol/l
0.24
208
1987
16
110
1.46
0.68
2.6
2.2
—
360.2
—
0
9
27
205
1.32
0.67
1.3
1.4
—
—
—
0
0
27
205
1.32
0.67
1.3
1.4
—
—
—
0
0
5
28
1.79
0.66
1.0
1.0
1576.8
1936.1
miu/ml
—
5
28
5
28
1.79
0.66
1.6
2.1
—
—
—
0
0
12
78
1.54
0.65
1.0
1.2
—
—
—
0
0
10
62
1.62
0.65
1.8
1.5
4.4
8.0
u/l
—
5
29
46
377
1.23
0.65
1.9
1.9
—
—
—
0
0
38
308
1.24
0.60
1.1
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
50
418
1.20
0.59
4.0
3.0
24.3
24.2
mmol/l
0.06
40
372
35
282
1.25
0.58
1.3
1.3
—
—
—
0
0
31
246
1.27
0.58
1.6
1.6
9913.9
11308.5
e6/l
0.14
24
181
144
1307
1.12
0.58
2.8
2.2
2.4
2.4
g/l
0.00
131
1206
8
53
1.51
0.58
1.0
1.0
—
—
—
0
0
8
54
1.48
0.57
1.3
1.1
204.4
264.5
mg/l
—
8
46
11
73
1.51
0.56
1.5
1.3
—
—
—
0
0
11
73
1.51
0.56
1.5
1.3
—
—
—
0
0
11
73
1.51
0.56
1.5
1.3
—
—
—
0
0
21
274
0.76
0.56
1.1
1.5
—
—
—
0
0
31
382
0.81
0.53
1.4
1.5
—
—
—
0
0
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
27
214
1.27
0.52
1.3
1.4
—
—
—
0
0
16
117
1.37
0.52
1.2
1.2
—
—
—
0
0
37
305
1.22
0.52
1.1
1.2
—
—
—
0
0
9
132
0.68
0.52
1.0
1.4
—
—
—
0
0
18
135
1.34
0.51
1.8
1.4
—
—
—
0
0
82
728
1.14
0.49
2.0
1.9
—
—
—
0
0
12
84
1.43
0.49
1.0
1.1
—
—
—
0
0
223
2089
1.08
0.49
1.3
1.4
—
—
—
0
0
7
50
1.40
0.45
1.0
1.0
—
—
—
0
0
74
658
1.13
0.45
1.9
1.8
—
—
—
0
0
37
311
1.20
0.45
3.9
2.1
38.4
37.8
g/l
0.27
32
270
28
229
1.23
0.44
1.1
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
276
1.20
0.42
2.0
2.5
0.3
0.4
u/ml
0.36
19
153
18
140
1.29
0.42
1.1
1.1
0.1
1.5
u/ml
—
7
53
131
1209
1.09
0.42
2.9
2.3
22.9
22.2
%
0.20
115
1035
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
17
132
1.29
0.40
1.4
1.1
2.1
2.2
u/ml
—
8
42
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
25
205
1.22
0.39
1.5
2.1
137.2
127.6
g/l
0.97
15
146
5
35
1.43
0.39
3.8
4.6
—
—
—
0
0
5
36
1.39
0.38
1.2
1.1
91.8
98.0
%
—
5
31
9
68
1.33
0.37
2.2
1.9
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
5
77
0.65
0.35
1.6
1.2
—
—
—
0
0
13
99
1.32
0.35
1.1
1.5
—
—
—
0
0
23
190
1.21
0.35
2.0
3.4
56.7
59.0
%
0.39
23
190
45
396
1.14
0.34
3.4
3.0
110.6
992.7
u/ml
1.23
35
340
37
321
1.16
0.34
6.4
3.9
1.3
1.4
mmol/l
0.27
37
315
13
166
0.78
0.33
1.2
1.3
—
—
—
0
0
6
46
1.31
0.33
1.0
1.0
—
—
—
0
0
25
213
1.18
0.29
1.3
1.4
—
—
—
0
0
26
223
1.17
0.28
1.5
1.2
—
—
—
0
0
13
103
1.27
0.28
7.8
5.6
12.6
11.9
mg/l
0.24
13
95
8
63
1.27
0.27
1.0
1.1
—
—
—
0
0
9
120
0.75
0.27
1.1
1.3
—
—
—
0
0
86
923
0.93
0.26
1.3
1.7
1.4
1.4
%
0.08
70
801
16
132
1.22
0.25
1.4
1.1
1.4
1.7
u/ml
—
8
34
15
123
1.22
0.25
1.7
1.5
—
—
—
0
0
9
74
1.22
0.25
1.0
1.0
—
—
—
0
0
16
133
1.21
0.24
1.0
1.0
3.0
1.9
u/ml
—
8
59
26
227
1.15
0.24
2.3
2.7
1.8
1.5
mg/l
0.58
21
206
105
990
1.07
0.23
2.9
3.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
82.3
—
0
6
16
189
0.84
0.22
1.3
1.4
—
—
—
0
0
25
284
0.88
0.22
1.3
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
8
104
0.77
0.21
4.5
2.4
13.3
13.3
%
—
8
104
5
43
1.16
0.21
2.0
1.3
—
—
—
0
0
5
43
1.16
0.21
2.0
1.3
—
—
—
0
0
151
1446
1.05
0.21
2.2
1.8
30.5
29.4
s
0.57
145
1393
11
89
1.24
0.21
1.5
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
1.3
—
0
13
0
13
0.00
0.21
0.0
5.6
—
—
—
0
0
12
144
0.83
0.20
1.2
1.3
—
—
—
0
0
56
520
1.08
0.19
1.1
1.0
—
—
—
0
0
883
8908
0.97
0.19
17.9
14.8
39.0
38.8
%
0.31
625
6251
22
194
1.14
0.18
1.8
1.7
—
—
—
0
0
14
119
1.18
0.17
1.1
1.4
—
—
—
0
0
7
62
1.13
0.17
1.0
1.5
—
—
—
0
0
36
330
1.09
0.17
1.4
1.6
—
—
—
0
0
46
427
1.08
0.17
1.6
1.7
—
—
—
0
0
70
740
0.94
0.16
1.7
1.7
—
—
—
0
0
8
72
1.11
0.16
1.1
1.5
—
—
—
0
0
9
83
1.08
0.14
1.6
1.3
—
—
—
0
0
38
355
1.07
0.12
1.4
1.7
2.1
4.1
mg/l
0.67
31
265
94
906
1.04
0.12
2.3
2.0
0.2
0.2
g/l
0.35
86
864
22
240
0.92
0.11
4.0
3.6
22.7
25.7
mg/l
0.12
13
145
43
454
0.95
0.10
1.2
1.4
—
—
—
0
0
14
125
1.12
0.10
1.2
1.5
49.8
60.4
%
—
8
75
5
45
1.11
0.10
2.4
2.6
—
—
—
0
0
39
369
1.06
0.09
3.7
2.3
9.1
10.1
g/l
1.38
34
317
25
266
0.94
0.07
1.1
1.3
203.4
247.6
miu/ml
—
10
125
29
274
1.06
0.07
1.5
1.5
0.0
0.1
iu/ml
0.67
12
57
52
502
1.04
0.06
1.2
1.4
—
—
—
0
0
812
8150
0.99
0.05
19.6
16.7
13.6
13.7
%
2.44
802
7966
28
291
0.96
0.04
3.6
3.4
23.4
40.9
mg/l
0.94
23
229
13
121
1.08
0.03
1.1
1.1
—
—
—
0
0
16
151
1.06
0.03
1.2
1.3
—
—
—
0
0
314
3122
1.01
0.03
3.0
3.0
27.8
34.2
u/l
1.47
299
2977
10
108
0.93
0.03
2.0
1.6
—
—
—
0
0
22
213
1.03
0.01
3.8
3.0
0.9
0.8
nmol/l
0.06
16
170
27
274
0.99
0.00
1.5
1.7
—
—
—
0
0
39
394
0.99
0.00
3.8
2.3
7.2
7.5
g/l
0.54
34
296
39
394
0.99
0.00
3.8
2.3
—
—
—
0
0
39
394
0.99
0.00
3.8
2.3
3.4
3.7
g/l
1.40
32
284
14
138
1.01
0.00
1.1
1.2
—
—
—
0
0
21
208
1.01
0.00
2.0
2.4
88.0
95.8
ug/min
—
8
118
12
123
0.98
0.00
1.2
1.3
—
—
—
0
0
27
267
1.01
0.00
3.1
1.9
89.7
92.2
%
0.23
27
251
14
135
1.04
0.00
1.1
1.1
—
—
—
0
0
12
125
0.96
0.00
1.8
1.4
—
116.5
—
0
28
12
125
0.96
0.00
1.0
1.1
—
—
—
0
0
8
86
0.93
0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
7.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.6
2.2
—
—
—
0
0
8
81
0.99
0.00
1.0
1.0
—
—
—
0
0
9
97
0.93
0.00
2.8
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
22.5
—
0
7
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
37.3
—
0
7
0
7
0.00
0.00
0.0
1.0
—
9.0
—
0
7
5
50
1.00
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITREDIFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREDIFF | 1.08 [0.97, 1.2] | 0.166 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 753 out of 4980 females with E4_GOITREDIFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREDIFF | 1.199 [1.0, 1.44] | 0.05 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 886 males with E4_GOITREDIFF died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITREDIFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.187% |
| 5 | 0.582% | 1.244% |
| 10 | 1.489% | 3.239% |
| 15 | 2.926% | 5.961% |
| 20 | 5.264% | 10.079% |
Relationships between endpoints
↥Index endpoint: E4_GOITREDIFF – Nontoxic diffuse goitre
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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