age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Background retinopathy and retinal vascular changes
DOID EFO Endpoint Browser PheWeb
H7_BCKRNDRETINOPAT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
749 |
4. Check minimum number of eventsNone |
749 |
5. Include endpointsNone |
749 |
6. Filter based on genotype QC (FinnGen only) |
749 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- H35
- Name in latin
- Retinopathia recessualis et commutationes vasculares retinae
Similar endpoints
↥List of similar endpoints to
Background retinopathy and retinal vascular changes
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6024 | 2953 | 3018 |
| Only index persons | 5178 | 2570 | 2608 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 59.07 | 63.57 | 54.72 |
| Only index persons | 58.11 | 62.71 | 53.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 749 | 363 | 386 |
| Unadjusted period prevalence (%) | 0.15 | 0.12 | 0.17 |
| Median age at first event (years) | 57.61 | 57.63 | 57.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 688
- Matched controls
- 6878
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
4503599627370496.0
323.0
638
*
XCK10
NOMESCO Finland
Photography of fundus of eye
14.3
134.7
249
262
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
232.7
131.8
132
7
CKC12
NOMESCO Finland
Photocoagulation of retina
228.4
129.6
130
7
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
17.0
104.1
173
133
XCD20
NOMESCO Finland
Photoangiography of eye
264.9
92.0
92
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
499.9
90.4
88
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
9.6
86.0
192
266
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
16.6
84.3
140
104
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
10.1
77.8
166
209
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
178.1
76.8
79
5
CKC10
NOMESCO Finland
Local photocoagulation of retina
140.0
71.5
75
6
H43.1
ICD-10 Finland
Vitreous haemorrhage
36.0
70.5
91
29
H34.8
ICD-10 Finland
Other retinal vascular occlusions
368.4
66.7
66
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.7
66.4
223
533
A10AA02
ATC
NA
19.1
65.5
102
62
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
21.1
64.6
97
53
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
72.9
63.7
72
11
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
32.4
62.8
83
29
H3601, E113
ICD-10 Finland
NA
+∞
62.5
59
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
28.5
59.3
81
32
A10AA01
ATC
NA
27.2
59.2
82
34
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
19.8
54.9
84
48
H36.01
ICD-10 Finland
Diabetic maculopathy
202.8
54.8
56
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.6
54.8
179
403
H3603, E103
ICD-10 Finland
NA
+∞
52.8
50
*
A10AE04
ATC
insulin glargine; parenteral
6.1
50.7
152
305
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
20.6
49.2
74
40
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
512.5
49.0
48
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
48.5
46
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
7.2
48.4
126
208
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
12.3
47.3
88
81
T89
ICPC
Diabetes insulin dependent
13.7
46.5
82
67
A10AE05
ATC
insulin detemir; parenteral
8.6
46.3
106
143
103
Kela drug reimbursment
Diabetes, insulin-treated
3.4
44.6
290
1211
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.3
43.8
102
141
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
32.6
43.4
57
19
H3600, E103
ICD-10 Finland
NA
+∞
43.2
41
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
443.7
42.6
42
*
WX140
NOMESCO Finland
Parabulbar anesthesy
17.1
41.8
67
43
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.1
41.8
67
43
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.4
40.6
252
1000
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
15.3
40.6
68
49
H3601, E103
ICD-10 Finland
NA
+∞
38.9
37
*
H3603, E113
ICD-10 Finland
NA
+∞
38.9
37
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.1
38.6
293
1331
H04AA01
ATC
glucagon; nasal, parenteral
21.3
38.6
57
29
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.0
38.5
313
1488
H36.00
ICD-10 Finland
Diabetic background retinopathy
89.4
38.2
42
5
H3600, E113
ICD-10 Finland
NA
+∞
36.8
35
*
Z94.0
ICD-10 Finland
Kidney transplant status
33.5
33.9
44
14
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
43.5
33.5
41
10
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
78.2
33.2
37
5
CKD40
NOMESCO Finland
Endophotocoagulation of retina
342.7
33.2
33
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
57.3
32.6
38
7
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.6
32.5
100
201
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
12.3
32.2
59
52
A11CC03
ATC
alfacalcidol; systemic
11.8
32.1
60
55
Z3229
NOMESCO Finland
Other healthcare associate professional
4.7
31.2
116
287
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
327.0
31.1
31
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
26.4
29.1
40
16
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
35.4
29.0
37
11
XCH00
NOMESCO Finland
Eye pressure measurement
8.5
28.6
64
82
127
Kela drug reimbursment
Transplant complication
21.2
28.6
42
21
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
28.4
464
3109
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
292.8
28.0
28
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
292.8
28.0
28
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
292.8
28.0
28
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
20.7
27.7
41
21
A12AA04
ATC
calcium carbonate; oral
14.9
27.5
46
33
C08CA01
ATC
amlodipine; oral
2.5
27.1
313
1731
C03CA01
ATC
furosemide; systemic
2.5
27.0
281
1467
ZXA10
NOMESCO Finland
Bilateral
3.1
26.7
177
701
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
26.2
25
*
137
Kela drug reimbursment
Uraemia requiring dialysis
25.2
25.9
36
15
H35.6
ICD-10 Finland
Retinal haemorrhage
270.2
25.9
26
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
26.2
25.5
35
14
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
40.5
25.1
31
8
N18.0
ICD-10 Finland
End-stage renal disease
20.5
25.0
37
19
H35.7
ICD-10 Finland
Separation of retinal layers
259.0
24.8
25
*
C02AC05
ATC
moxonidine; oral
6.5
24.4
65
108
A10AE06
ATC
insulin degludec; parenteral
10.0
23.9
48
51
XCK00
NOMESCO Finland
Perimetry
4.5
23.9
90
224
205
Kela drug reimbursment
Chronic hypertension
2.4
23.5
270
1456
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
23.4
221
1073
N18.8
ICD-10 Finland
Other chronic renal failure
7.9
23.4
54
73
L04AA06
ATC
mycophenolic acid; systemic
14.7
23.3
39
28
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
19.3
23.3
35
19
C09AA02
ATC
enalapril; systemic
2.6
23.2
199
916
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
46.7
22.5
27
6
H35.9
ICD-10 Finland
Retinal disorder, unspecified
+∞
22.0
21
*
SPAT1262
SPAT
Handing over of treatment supplies
2.8
21.9
169
726
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.5
21.8
48
60
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
82.9
21.8
24
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.5
21.6
209
1020
B05DA
ATC
Isotonic solutions
27.4
21.5
29
11
TK800
NOMESCO Finland
Hemodialysis
9.7
21.1
43
47
V03AE01
ATC
polystyrene sulfonate; oral
15.5
20.9
34
23
S01EC01
ATC
acetazolamide; systemic
7.9
20.8
48
65
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
216.2
20.7
21
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
17.6
20.7
32
19
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
14.8
20.5
34
24
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
28.0
20.2
27
10
H26.4
ICD-10 Finland
After-cataract
3.6
20.0
96
296
S01BC03
ATC
diclofenac; ophthalmic
8.1
19.9
45
59
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
19.9
19
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
75.8
19.8
22
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
108.2
19.7
21
*
B05DB
ATC
Hypertonic solutions
25.5
19.7
27
11
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
25.5
19.7
27
11
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
32.3
19.4
25
8
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.3
19.1
33
26
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
18.9
328
2083
Z49.2
ICD-10 Finland
Other dialysis
24.5
18.8
26
11
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
21.6
18.7
27
13
B03XA02
ATC
darbepoetin alfa; parenteral
9.5
18.1
37
41
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
68.5
17.8
20
*
S01ED51
ATC
timolol, combinations; ophthalmic
3.8
17.8
79
228
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
19.2
17.4
26
14
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
17.3
292
1813
H26.02
ICD-10 Finland
Presenil cataract
8.6
17.2
37
45
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
32.4
17.1
22
7
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
11.1
17.1
32
30
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
22.5
17.0
24
11
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
10.1
16.8
33
34
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
36.0
16.7
21
6
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
16.7
16
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
41.2
16.4
20
5
ZXA05
NOMESCO Finland
Left side
2.2
16.3
200
1077
ZXA00
NOMESCO Finland
Right side
2.2
16.3
210
1154
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
30.9
16.2
21
7
V03AE02
ATC
sevelamer; oral
30.9
16.2
21
7
B01AC04
ATC
clopidogrel; oral
2.4
15.7
145
678
C10AA05
ATC
atorvastatin; oral
2.0
15.7
285
1801
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.4
15.7
78
247
H43.8
ICD-10 Finland
Other disorders of vitreous body
3.6
15.6
74
225
C07AB07
ATC
bisoprolol; oral
1.9
15.6
357
2460
WX002
NOMESCO Finland
Sedation and analgesia
2.4
15.6
155
752
J01FF01
ATC
clindamycin; systemic
2.1
15.6
206
1143
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.1
15.6
92
329
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
39.0
15.4
19
5
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
10.8
15.3
29
28
C10AA01
ATC
simvastatin; oral
1.9
14.9
328
2215
177
Kela drug reimbursment
Insulin glargine 300 U / ml
8.6
14.9
32
39
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
32.5
14.9
19
6
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.2
14.7
182
975
H35.36
ICD-10 Finland
Macular cyst
+∞
14.6
14
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
14.6
206
1170
V03AE03
ATC
lanthanum carbonate; oral
36.9
14.5
18
5
H26.2
ICD-10 Finland
Complicated cataract
15.8
14.5
23
15
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.9
14.4
40
71
T90
ICPC
Diabetes non-insulin dependent
2.2
14.2
177
952
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.1
14.1
196
1103
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
20.5
13.8
20
10
B03XA01
ATC
erythropoietin; parenteral
13.9
13.8
23
17
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
13.6
13
*
36701
ICD-8 Finland
Inflammation of optic nerve and retina, Periphlebitis retinae
+∞
13.6
13
*
C08CA13
ATC
lercanidipine; oral
2.5
13.2
112
498
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
40.9
13.2
16
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
29.0
13.0
17
6
H20.1
ICD-10 Finland
Chronic iridocyclitis
13.3
13.0
22
17
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
13.0
162
868
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
12.9
93
378
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
5.3
12.6
38
75
S01BC05
ATC
ketorolac; ophthalmic
4.4
12.6
45
107
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
12.5
12
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
12.5
12
*
37709
ICD-8 Finland
Other diseases of retina and optic nerve, Laesio vascularis retinae NUD
+∞
12.5
12
*
1LA05
NOMESCO Finland
NA
+∞
12.5
12
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
24.8
12.5
17
7
Z3231
NOMESCO Finland
Registered nurse
2.0
12.5
199
1171
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
132.3
12.5
13
*
H40.0
ICD-10 Finland
Glaucoma suspect
3.2
12.4
65
214
H25.8
ICD-10 Finland
Other senile cataract
2.6
12.4
99
425
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
6.3
12.2
32
53
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
38.3
12.2
15
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
12.2
100
435
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
4.7
12.1
41
92
C08CA02
ATC
felodipine; oral
2.6
12.1
91
376
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
12.1
63
207
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.4
11.9
43
103
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.6
11.9
88
362
S01ED01
ATC
timolol; ophthalmic
4.3
11.7
43
105
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
66.1
11.6
13
*
ZX198
NOMESCO Finland
Other local administration
19.3
11.6
17
9
H3602, E103
ICD-10 Finland
NA
+∞
11.5
11
*
H35.37
ICD-10 Finland
Macular holes
+∞
11.5
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
11.5
124
618
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
35.7
11.3
14
*
TK820
NOMESCO Finland
Peritoneal dialysis
17.4
11.2
17
10
N02BE01
ATC
paracetamol; systemic, rectal
2.0
11.2
572
4905
S01EE01
ATC
latanoprost; ophthalmic
3.3
11.2
57
184
S01EC04
ATC
brinzolamide; ophthalmic
4.3
11.2
41
100
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
25.5
11.2
15
6
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
6.0
11.1
30
52
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
11.1
89
383
S01EA03
ATC
apraclonidine; ophthalmic
14.2
11.0
18
13
SPAT1254
SPAT
Administration of medicine
2.2
11.0
119
596
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
10.9
107
510
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
10.9
267
1810
L04AA01
ATC
[U] ciclosporin; systemic
9.1
10.8
22
25
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
9.8
10.8
21
22
196
Kela drug reimbursment
Paricalcitol and cinacalcet
18.2
10.8
16
9
H47.1
ICD-10 Finland
Papilloedema, unspecified
61.0
10.6
12
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
10.6
124
640
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
+∞
10.4
10
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
10.4
10
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
+∞
10.4
10
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
+∞
10.4
10
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
10.4
10
*
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
6.4
10.2
26
42
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
6.4
10.2
26
42
J01DB01
ATC
cefalexin; oral
1.8
10.2
532
4487
A02BC02
ATC
pantoprazole; systemic
1.7
10.2
420
3297
A10BB01
ATC
glibenclamide; oral
3.3
10.2
50
158
C01DA14
ATC
isosorbide mononitrate; oral
2.0
10.1
136
743
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.3
10.1
51
165
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
10.0
151
862
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
10.0
120
625
H05BX01
ATC
cinacalcet; oral
12.4
9.9
17
14
SPAT1301
SPAT
No procedures
1.8
9.8
213
1380
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
26.4
9.8
13
5
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
20.4
9.8
14
7
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.9
9.7
149
855
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
9.7
181
1117
A10BA02
ATC
metformin; oral
1.8
9.7
203
1301
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
9.6
136
756
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
11.6
9.6
17
15
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.5
9.5
44
133
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
9.4
205
1328
R06.0
ICD-10 Finland
Dyspnoea
1.8
9.4
177
1092
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
9.4
9
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
9.4
9
*
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
9.4
9
*
3621A
ICD-9 Finland
Other retinal disorders, Other background retinopathy and retinal vascular changes
+∞
9.4
9
*
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
9.4
9
*
S01EC03
ATC
dorzolamide; ophthalmic
7.1
9.4
22
32
N19
ICD-10 Finland
Unspecified kidney failure
3.9
9.4
37
98
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
9.3
228
1528
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
5.2
9.3
28
56
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
9.3
65
257
NHQ40
NOMESCO Finland
Amputation of toe
6.6
9.3
23
36
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
9.2
165
999
U14
ICPC
Kidney symptom/complaint
6.8
9.2
22
33
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
8.5
9.1
19
23
ZXD05
NOMESCO Finland
Urgent procedure
1.7
9.1
213
1407
ZX120
NOMESCO Finland
Intravenous
2.4
9.0
76
335
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
9.0
72
308
H02AB06
ATC
prednisolone; systemic
1.6
8.8
309
2283
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
8.8
44
142
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
50.6
8.7
10
*
SPAT1263
SPAT
Sampling
1.7
8.7
268
1911
C09AA05
ATC
ramipril; oral
1.8
8.6
187
1202
114
Kela drug reimbursment
Glaucoma
2.4
8.6
71
311
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.4
8.6
40
122
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
8.5
146
869
H25.0
ICD-10 Finland
Senile incipient cataract
3.0
8.5
48
167
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.8
8.4
20
30
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
8.3
8
*
H360, E113
ICD-10 Finland
NA
+∞
8.3
8
*
37712
ICD-8 Finland
Other diseases of retina and optic nerve, Retinitis exsudativa externa (Coats)
+∞
8.3
8
*
G63.2
ICD-10 Finland
Diabetic polyneuropathy
14.7
8.2
13
9
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
8.2
102
539
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
8.1
95
488
171
Kela drug reimbursment
Degludekinsuliini
33.8
8.1
10
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
33.8
8.1
10
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
8.0
121
688
WX199
NOMESCO Finland
Other local analgesia
4.5
8.0
27
62
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.0
161
1009
H16.0
ICD-10 Finland
Corneal ulcer
3.4
8.0
37
113
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
7.9
140
841
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
7.9
51
195
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.1
7.9
96
504
ZXE00
NOMESCO Finland
One hour or less
1.6
7.9
253
1815
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.1
7.8
29
73
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.2
7.8
39
126
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
7.8
36
110
A10BB12
ATC
glimepiride; oral
2.4
7.7
67
301
I21.4
ICD-10 Finland
Acute subendocardial myocardial infarction
6.8
7.6
18
27
PC5DE
NOMESCO Finland
Ultrasound of kidney circulation with Doppler technic
25.3
7.6
10
*
A10AB06
ATC
insulin glulisine; parenteral
9.0
7.6
15
17
C09CA06
ATC
candesartan; oral
1.8
7.6
148
917
C10AA04
ATC
fluvastatin; oral
2.3
7.6
67
305
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
7.5
111
626
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
6.6
7.4
18
28
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.7
7.4
48
184
N08.3
ICD-10 Finland
Glomerular disorders in diabetes mellitus
80.9
7.4
8
*
D31.2
ICD-10 Finland
Benign neoplasm: Retina
80.9
7.4
8
*
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
7.8
7.4
16
21
I15.0
ICD-10 Finland
Renovascular hypertension
13.5
7.4
12
9
Z2446
NOMESCO Finland
Social worker
2.6
7.3
52
211
H02AB04
ATC
methylprednisolone; systemic
1.9
7.3
103
571
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
+∞
7.3
7
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
7.3
7
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
7.3
7
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
7.3
7
*
H360, E103
ICD-10 Finland
NA
+∞
7.3
7
*
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
7.3
7
*
3624A
ICD-9 Finland
Other retinal disorders, Separation of retinal layers[RETINOPATHIA CENTRALIS SEROSA]
+∞
7.3
7
*
H34.9
ICD-10 Finland
Retinal vascular occlusion, unspecified
+∞
7.3
7
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.2
7.3
26
64
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
15.9
7.2
11
7
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.4
7.2
57
245
L04AD01
ATC
ciclosporin; systemic
4.9
7.2
22
46
J01MA12
ATC
levofloxacin; systemic
1.8
7.2
126
756
L04AX01
ATC
azathioprine; systemic
3.2
7.1
36
118
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.9
7.1
41
146
H53.4
ICD-10 Finland
Visual field defects
4.8
7.1
22
47
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
7.1
55
233
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
2.6
7.0
49
196
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
7.0
175
1165
C02CA01
ATC
prazosin; oral
4.3
7.0
24
57
L28
ICPC
Limited function/disability (L)
1.9
6.9
109
628
C09CA01
ATC
losartan; oral
1.7
6.9
159
1034
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.9
6.9
21
44
SPAT1325
SPAT
Vaccination
1.6
6.9
213
1501
AN1
HP
Coronary angiography
2.0
6.9
90
483
3AC01
NOMESCO Finland
NA
8.4
6.8
14
17
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
6.8
60
273
H18.2
ICD-10 Finland
Other corneal oedema
40.5
6.8
8
*
M14.6
ICD-10 Finland
Neuropathic arthropathy
40.5
6.8
8
*
C07AB02
ATC
metoprolol; systemic
1.7
6.8
150
963
XF402
NOMESCO Finland
ECG with work load test
2.1
6.7
79
405
R51.80
ICD-10 Finland
Headache
2.0
6.7
85
450
Z2221
NOMESCO Finland
Medical doctor
1.6
6.7
178
1201
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
6.7
64
304
RS221
NOMESCO Finland
NA
5.6
6.6
18
33
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.8
6.5
26
71
E87.5
ICD-10 Finland
Hyperkalaemia
5.1
6.5
19
38
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
6.5
86
466
S97
ICPC
Chronic ulcer skin
2.7
6.5
42
161
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
6.5
52
225
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.4
6.5
21
553
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
6.5
46
187
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
4.3
6.5
22
52
QDH
NOMESCO Finland
Operations on toe nails
70.5
6.4
7
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
14.5
6.4
10
7
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.4
269
2034
A46
ICD-10 Finland
Erysipelas
1.9
6.4
99
567
A10AA03
ATC
NA
8.3
6.4
13
16
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.3
180
1235
N03AX16
ATC
pregabalin; oral
1.7
6.3
152
996
S18
ICPC
Laceration/cut
1.5
6.3
257
1928
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
5.6
6.3
17
31
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.3
227
1655
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
6.3
6
*
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
+∞
6.3
6
*
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
6.3
6
*
JL9AE
NOMESCO Finland
Ultrasound examination of pancreas transplant
+∞
6.3
6
*
R4190
NOMESCO Finland
Nutritional therapy
3.6
6.3
26
74
M14.6*A52.1
ICD-10 Finland
Charcot's or tabetic arthropathy
26.9
6.2
8
*
SPAT1097
SPAT
Recording of ECG
1.8
6.2
100
581
RD210
NOMESCO Finland
NA
5.1
6.2
18
36
H57.1
ICD-10 Finland
Ocular pain
4.5
6.2
20
45
WX892
NOMESCO Finland
Monitored bed care
2.3
6.2
56
259
R60.0
ICD-10 Finland
Localized oedema
2.0
6.2
79
420
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.1
250
1871
E66.01
ICD-10 Finland
Obesity due to excess calories
2.4
6.1
49
211
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.6
6.0
16
29
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint H7_BCKRNDRETINOPAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BCKRNDRETINOPAT | 1.398 [1.23, 1.59] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.678 |
During the follow-up period (1.1.1998 — 31.12.2019), 810 out of 2446 females with H7_BCKRNDRETINOPAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BCKRNDRETINOPAT | 1.353 [1.17, 1.56] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 716 out of 2418 males with H7_BCKRNDRETINOPAT died.
Mortality risk
Mortality risk for people of age
years, who have H7_BCKRNDRETINOPAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.271% |
| 5 | 0.836% | 1.616% |
| 10 | 2.152% | 4.152% |
| 15 | 4.438% | 7.965% |
| 20 | 7.889% | 13.748% |
Relationships between endpoints
↥Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data