Background retinopathy and retinal vascular changes

H7_BCKRNDRETINOPAT

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H35.0
  • Hospital discharge: ICD-9 3621|3624A
  • Hospital discharge: ICD-8 36701|37705|37709|37712
  • Cause of death: ICD-10 H35.0
  • Cause of death: ICD-9 3621|3624A
  • Cause of death: ICD-8 36701|37705|37709|37712

2 out of 7 registries used, show all original rules.

794

4. Check minimum number of events

None

794

5. Include endpoints

None

794

6. Filter based on genotype QC (FinnGen only)

763

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
H35
Name in latin
Retinopathia recessualis et commutationes vasculares retinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6024 2953 3018
Only index persons 5178 2570 2608
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.08
Only index persons 0.10 0.09 0.10
Median age at first event (years)
Whole population 59.07 63.57 54.72
Only index persons 58.11 62.71 53.57

-FinnGen-

Key figures

All Female Male
Number of individuals 763 368 395
Unadjusted period prevalence (%) 0.16 0.13 0.18
Median age at first event (years) 58.30 58.83 57.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
794
Matched controls
7940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
4503599627370496.0
307.7
718
*
XCK10
NOMESCO Finland
Photography of fundus of eye
14.1
252.2
278
293
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.3
231.1
192
123
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
14.3
217.0
225
213
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.0
197.1
233
266
H43.1
ICD-10 Finland
Vitreous haemorrhage
47.1
185.1
110
27
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
362.5
175.5
171
6
CKC12
NOMESCO Finland
Photocoagulation of retina
299.1
168.6
166
7
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
37.5
152.5
96
29
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
37.9
145.1
91
27
A10AA02, ,
ATC
18.7
139.8
116
72
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
37.5
138.4
87
26
A10AB01
ATC
insulin (human); parenteral
18.9
133.7
110
67
A10AC01
ATC
insulin (human); parenteral
8.7
129.1
189
276
A10AA01, ,
ATC
24.9
128.7
93
42
T89
ICPC
Diabetes insulin dependent
14.3
117.0
112
90
A10AB04
ATC
insulin lispro; parenteral
17.4
113.8
97
63
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.7
112.6
280
692
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
420.4
112.4
110
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
13.3
104.3
104
89
XCD20
NOMESCO Finland
Photoangiography of eye
174.4
103.0
106
7
A10AE04
ATC
insulin glargine; parenteral
6.6
101.7
192
364
A10AB05
ATC
insulin aspart; parenteral
7.6
101.4
162
258
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
15.8
99.5
89
63
H04AA01
ATC
glucagon; nasal, parenteral
27.0
96.3
67
27
A10AE05
ATC
insulin detemir; parenteral
8.8
91.2
125
166
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
25.2
91.1
65
28
WX140
NOMESCO Finland
Parabulbar anesthesy
15.1
90.8
83
61
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
171.0
88.1
91
6
XCH00
NOMESCO Finland
Eye pressure measurement
10.0
84.8
103
117
CKC10
NOMESCO Finland
Local photocoagulation of retina
453.0
83.6
82
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.9
80.7
222
582
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.6
79.9
123
186
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
41.6
77.2
47
12
H34.8
ICD-10 Finland
Other retinal vascular occlusions
409.9
76.1
75
*
H36.01
ICD-10 Finland
Diabetic maculopathy
403.8
75.1
74
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.5
72.5
74
65
Z94.0
ICD-10 Finland
Kidney transplant status
26.6
71.8
50
20
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.7
71.4
72
62
H3601, E113,
ICD-10 Finland
+∞
69.8
66
*
103
Kela drug reimbursment
Diabetes, insulin-treated
3.5
64.9
349
1443
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
657.7
62.7
61
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
29.5
62.5
42
15
127
Kela drug reimbursment
Transplant complication
16.8
61.1
52
33
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.5
60.8
306
1205
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
60.2
57
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.6
59.3
125
257
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
20.3
59.3
46
24
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
11.1
58.6
64
62
H3603, E103,
ICD-10 Finland
+∞
58.0
55
*
A10AE06
ATC
insulin degludec; parenteral
8.9
57.7
75
92
A11CC03
ATC
alfacalcidol; systemic
9.6
56.6
69
78
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.3
54.7
40
18
H33.0
ICD-10 Finland
Retinal detachment with retinal break
553.3
53.1
52
*
137
Kela drug reimbursment
Uraemia requiring dialysis
22.7
52.8
39
18
E10
ICD-10 Finland
Type 1 diabetes mellitus
17.4
51.7
43
26
Z3229
NOMESCO Finland
Other healthcare associate professional
4.7
51.3
133
325
A12AA04
ATC
calcium carbonate; oral
12.6
51.0
51
43
XCK00
NOMESCO Finland
Perimetry
5.6
48.6
99
196
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.0
48.5
362
1748
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
16.6
48.1
41
26
Z49.0
ICD-10 Finland
Preparatory care for dialysis
17.0
46.4
39
24
L04AA06
ATC
mycophenolic acid; systemic
11.5
46.4
49
45
H3600, E103,
ICD-10 Finland
+∞
46.3
44
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
127.5
45.3
48
*
N18.0
ICD-10 Finland
End-stage renal disease
15.7
44.5
39
26
H3603, E113,
ICD-10 Finland
+∞
44.2
42
*
S01BC03
ATC
diclofenac; ophthalmic
10.4
44.0
50
51
N18.8
ICD-10 Finland
Other chronic renal failure
8.9
43.8
56
67
TK800
NOMESCO Finland
Hemodialysis
9.2
42.7
53
61
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.7
41.2
363
1874
S01EC01
ATC
acetazolamide; systemic
9.5
41.1
50
56
H3601, E103,
ICD-10 Finland
+∞
41.0
39
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.4
39.6
53
67
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
14.5
39.3
36
26
ZXA10
NOMESCO Finland
Bilateral
3.1
39.0
212
844
A10AD01
ATC
insulin (human); parenteral
12.0
39.0
40
35
H3600, E113,
ICD-10 Finland
+∞
38.9
37
*
V03AE01
ATC
polystyrene sulfonate; oral
12.8
38.6
38
31
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
75.5
38.3
43
6
Z49.1
ICD-10 Finland
Extracorporeal dialysis
11.7
37.4
39
35
CKD40
NOMESCO Finland
Endophotocoagulation of retina
384.6
37.3
37
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
384.6
37.3
37
*
C03CA01
ATC
furosemide; systemic
2.6
37.0
349
1841
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
193.8
36.1
37
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
193.8
36.1
37
*
H26.4
ICD-10 Finland
After-cataract
3.8
36.0
123
365
H33.3
ICD-10 Finland
Retinal breaks without detachment
362.5
35.2
35
*
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
9.8
34.7
41
44
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
34.6
33
*
B03XA02
ATC
darbepoetin alfa; parenteral
8.1
34.3
47
61
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
33.6
32
*
205
Kela drug reimbursment
Chronic hypertension
2.5
32.5
305
1584
C02AC05
ATC
moxonidine; oral
4.6
31.5
80
190
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
10.7
30.9
34
33
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
30.4
29
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
30.0
559
3881
C09AA02
ATC
enalapril; systemic
2.6
29.8
227
1061
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
29.3
28
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
33.2
29.3
38
12
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
29.2
29.1
39
14
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
35.2
28.9
37
11
C08CA01
ATC
amlodipine; oral
2.3
28.8
377
2237
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
40.6
28.2
35
9
177
Kela drug reimbursment
Insulin glargine 300 U / ml
8.5
27.6
36
44
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.6
26.8
96
292
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.1
26.8
59
124
H25.1
ICD-10 Finland
Senile nuclear cataract
2.3
26.8
280
1500
SPAT1262
SPAT
Handing over of treatment supplies
2.6
26.3
186
833
S01ED51
ATC
timolol, combinations; ophthalmic
3.6
26.1
94
287
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
37.0
25.4
32
9
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
60.1
25.2
29
5
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
5.3
24.5
51
102
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
24.1
23
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
7.0
24.0
37
55
T90
ICPC
Diabetes non-insulin dependent
2.3
23.7
229
1176
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
29.3
23.3
31
11
L04AD02
ATC
tacrolimus; systemic
19.2
23.2
35
19
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
23.1
250
1346
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
33.4
22.5
29
9
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.9
22.4
121
470
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
25.9
21.9
30
12
B05DB
ATC
Hypertonic solutions
23.0
21.8
31
14
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
226.0
21.7
22
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
118.3
21.7
23
*
B05DA
ATC
Isotonic solutions
21.4
21.4
31
15
H25.8
ICD-10 Finland
Other senile cataract
2.8
21.4
117
457
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
34.9
21.2
27
8
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
34.9
21.2
27
8
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
61.8
21.0
24
*
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
20.9
20
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
79.0
20.8
23
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
3.1
20.7
93
325
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
215.4
20.7
21
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
20.2
359
2306
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.5
20.2
51
120
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
20.2
406
2724
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
20.0
73
224
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.7
19.9
123
511
H26.02
ICD-10 Finland
Presenil cataract
5.5
19.8
39
74
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
16.9
19.8
31
19
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
107.7
19.6
21
*
J01FF01
ATC
clindamycin; systemic
2.1
19.3
240
1349
Z49.2
ICD-10 Finland
Other dialysis
18.8
19.2
29
16
WX002
NOMESCO Finland
Sedation and analgesia
2.3
18.9
178
896
H35.36
ICD-10 Finland
Macular cyst
+∞
18.8
18
*
V03AE02
ATC
sevelamer; oral
28.6
18.8
25
9
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
102.5
18.6
20
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
194.4
18.6
19
*
H26.2
ICD-10 Finland
Complicated cataract
19.9
18.3
27
14
C07AB07
ATC
bisoprolol; oral
1.9
18.2
434
3047
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.1
18.0
50
127
B01AC04
ATC
clopidogrel; oral
2.2
17.6
174
890
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
17.5
126
562
H20.1
ICD-10 Finland
Chronic iridocyclitis
21.5
17.4
25
12
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.0
17.3
230
1319
S01ED01
ATC
timolol; ophthalmic
4.1
17.2
48
122
ZXA00
NOMESCO Finland
Right side
2.0
17.2
241
1407
XCW10
NOMESCO Finland
Assessment of vision
16.4
17.1
27
17
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
26.3
17.0
23
9
A10AD05
ATC
insulin aspart; parenteral
5.5
17.0
33
62
C08CA13
ATC
lercanidipine; oral
2.3
16.9
142
677
Z3231
NOMESCO Finland
Registered nurse
2.0
16.8
238
1393
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
16.7
16
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.0
16.7
236
1380
C10AA05
ATC
atorvastatin; oral
1.9
16.6
359
2418
A10BB01
ATC
glibenclamide; oral
3.6
16.5
56
164
C10AA01
ATC
simvastatin; oral
1.9
16.2
375
2577
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
4.6
16.1
39
89
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
16.0
119
538
36701
ICD-8 Finland
Inflammation of optic nerve and retina, Periphlebitis retinae
+∞
15.7
15
*
ZXA05
NOMESCO Finland
Left side
2.0
15.6
223
1304
196
Kela drug reimbursment
Paricalcitol and cinacalcet
22.6
15.6
22
10
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
22.6
15.6
22
10
H35.37
ICD-10 Finland
Macular holes
163.1
15.5
16
*
S01EC03
ATC
dorzolamide; ophthalmic
6.6
15.4
25
39
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
15.4
217
1263
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
45.9
15.1
18
*
C08CA02
ATC
felodipine; oral
2.5
15.1
103
447
A10BA02
ATC
metformin; oral
1.9
14.8
254
1577
V03AE03
ATC
lanthanum carbonate; oral
25.6
14.7
20
8
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
14.6
101
440
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
14.6
161
854
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
14.6
14
*
37709
ICD-8 Finland
Other diseases of retina and optic nerve, Laesio vascularis retinae NUD
+∞
14.6
14
*
S01EA05
ATC
brimonidine; ophthalmic
4.6
14.6
35
79
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
14.5
14.6
24
17
H35.4
ICD-10 Finland
Peripheral retinal degeneration
152.7
14.5
15
*
NHQ40
NOMESCO Finland
Amputation of toe
5.7
14.4
27
49
H02AB04
ATC
methylprednisolone; systemic
2.2
14.2
133
661
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.8
14.1
22
33
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
14.0
150
786
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.0
14.0
65
231
ZX120
NOMESCO Finland
Intravenous
2.5
13.9
92
393
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.7
13.9
25
22
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.2
13.7
37
92
1LA05, ,
NOMESCO Finland
+∞
13.6
13
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
34.7
13.5
17
5
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
16.5
13.5
21
13
H40.0
ICD-10 Finland
Glaucoma suspect
2.7
13.2
75
297
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
40.8
13.2
16
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
13.0
78
317
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.4
13.0
33
78
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
4.6
12.9
31
70
B03XA01
ATC
erythropoietin; parenteral
11.8
12.9
23
20
S01EC04
ATC
brinzolamide; ophthalmic
3.5
12.8
45
135
C02CA01
ATC
prazosin; oral
5.2
12.8
26
51
S01EE01
ATC
latanoprost; ophthalmic
2.8
12.8
65
243
SPAT1254
SPAT
Administration of medicine
2.1
12.7
134
697
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.1
12.6
54
183
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
12.5
306
2092
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
+∞
12.5
12
*
H3601, H350,
ICD-10 Finland
+∞
12.5
12
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
12.5
12
*
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
+∞
12.5
12
*
ZX198
NOMESCO Finland
Other local administration
13.4
12.5
21
16
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
4.5
12.5
30
68
C09CA06
ATC
candesartan; oral
1.9
12.4
190
1126
S01EA03
ATC
apraclonidine; ophthalmic
11.9
12.4
22
19
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
12.2
170
977
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
6.1
12.2
21
35
H05BX01
ATC
cinacalcet; oral
11.9
11.9
21
18
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.1
11.8
32
80
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
16.7
11.7
18
11
TK820
NOMESCO Finland
Peritoneal dialysis
16.7
11.7
18
11
L04AD01
ATC
ciclosporin; systemic
5.6
11.7
22
40
J01DB01
ATC
cefalexin; oral
1.9
11.5
637
5413
H53.4
ICD-10 Finland
Visual field defects
4.6
11.5
27
60
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
11.5
11
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
11.5
11
*
H3602, E103,
ICD-10 Finland
+∞
11.5
11
*
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
11.5
11
*
S01BC05
ATC
ketorolac; ophthalmic
3.2
11.5
46
150
H34.2
ICD-10 Finland
Other retinal artery occlusions
121.7
11.5
12
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
121.7
11.5
12
*
A10BB12
ATC
glimepiride; oral
2.5
11.4
76
325
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
11.4
183
1099
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.6
11.4
68
276
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
11.3
273
1848
U14
ICPC
Kidney symptom/complaint
5.2
11.3
23
45
L04AA01
ATC
[U] ciclosporin
9.1
11.3
23
26
114
Kela drug reimbursment
Glaucoma
2.4
11.3
83
372
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
5.8
11.0
20
35
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
11.0
101
497
S97
ICPC
Chronic ulcer skin
2.7
10.9
62
245
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
12.1
10.9
19
16
N19
ICD-10 Finland
Unspecified kidney failure
3.2
10.8
44
145
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
10.6
146
833
R06.0
ICD-10 Finland
Dyspnoea
1.7
10.5
224
1459
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.1
10.5
110
570
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
5.5
10.4
20
37
S91.1
ICD-10 Finland
Open wound of toe(s) without damage to nail
5.5
10.4
20
37
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
10.4
10
*
SPAT1301
SPAT
No procedures
1.7
10.4
244
1633
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
10.4
55
210
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
33.0
10.4
13
*
C01DA14
ATC
isosorbide mononitrate; oral
1.9
10.3
153
893
C08CA10
ATC
nilvadipine; oral
4.5
10.3
25
57
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.7
10.3
57
223
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
10.2
199
1262
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
4.2
10.2
27
66
H02AB06
ATC
prednisolone; systemic
1.6
10.2
368
2750
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.7
10.2
32
89
J01MA02
ATC
ciprofloxacin; systemic
1.6
10.2
311
2229
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
10.1
57
225
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
10.1
120
650
C10AX09
ATC
ezetimibe; oral
2.0
10.1
127
702
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
9.9
225
1489
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.9
9.9
48
175
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
9.9
66
283
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
26.4
9.8
13
5
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
9.7
9.8
19
20
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
9.7
147
863
R4190
NOMESCO Finland
Nutritional therapy
3.3
9.7
36
112
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
9.7
40
133
H25.0
ICD-10 Finland
Senile incipient cataract
2.6
9.6
57
231
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
9.6
87
426
A02BC02
ATC
pantoprazole; systemic
1.6
9.5
515
4218
E87.5
ICD-10 Finland
Hyperkalaemia
4.3
9.4
24
57
H34.9
ICD-10 Finland
Retinal vascular occlusion, unspecified
+∞
9.4
9
*
3621A
ICD-9 Finland
Other retinal disorders, Other background retinopathy and retinal vascular changes
+∞
9.4
9
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
9.4
9
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
9.4
9
*
3624A
ICD-9 Finland
Other retinal disorders, Separation of retinal layers[RETINOPATHIA CENTRALIS SEROSA]
+∞
9.4
9
*
37712
ICD-8 Finland
Other diseases of retina and optic nerve, Retinitis exsudativa externa (Coats)
+∞
9.4
9
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
9.4
9
*
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
9.4
9
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
9.4
9
*
H3603, E106,
ICD-10 Finland
+∞
9.4
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.4
173
1078
A10AA03, ,
ATC
10.8
9.3
17
16
C09AA05
ATC
ramipril; oral
1.7
9.3
219
1460
RD210, ,
NOMESCO Finland
5.1
9.1
19
38
WX199
NOMESCO Finland
Other local analgesia
3.4
9.1
33
101
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.9
9.1
44
160
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
9.1
55
225
M14.6*A52.1
ICD-10 Finland
Charcot's or tabetic arthropathy
37.1
9.0
11
*
L28
ICPC
Limited function/disability (L)
1.8
9.0
149
898
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
18.8
9.0
13
7
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
8.9
115
639
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
24.3
8.9
12
5
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.7
8.9
196
1281
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.9
683
6075
L04AX01
ATC
azathioprine; systemic
3.0
8.8
39
135
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
2.4
8.8
60
260
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
8.8
107
584
R60.0
ICD-10 Finland
Localized oedema
2.0
8.7
98
519
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
14.2
8.7
14
10
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
50.6
8.7
10
*
J01MA12
ATC
levofloxacin; systemic
1.8
8.6
153
940
CS494
NOMESCO Finland
Other visual field testing
3.7
8.6
27
75
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
8.6
56
237
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.9
8.6
41
148
WX872
NOMESCO Finland
Intensive care
2.6
8.6
51
207
A46
ICD-10 Finland
Erysipelas
1.9
8.5
124
717
ZXD05
NOMESCO Finland
Urgent procedure
1.6
8.5
239
1662
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
8.5
70
329
A12AA12
ATC
[U] calcium acetate
27.8
8.5
11
*
171
Kela drug reimbursment
Degludekinsuliini
27.8
8.5
11
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
91.0
8.4
9
*
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.4
216
1469
H360, E113,
ICD-10 Finland
+∞
8.3
8
*
H3601, E116,
ICD-10 Finland
+∞
8.3
8
*
H360, E103,
ICD-10 Finland
+∞
8.3
8
*
H16.0
ICD-10 Finland
Corneal ulcer
2.6
8.3
47
186
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.6
8.2
47
187
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
8.2
100
546
Z2446
NOMESCO Finland
Social worker
2.4
8.1
58
256
C09CA01
ATC
losartan; oral
1.7
8.1
203
1368
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.7
8.1
169
1088
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
22.3
8.0
11
5
S18
ICPC
Laceration/cut
1.5
8.0
338
2576
OAB50, ,
SPAT
2.5
8.0
48
196
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
7.9
200
1350
I21.4
ICD-10 Finland
Acute subendocardial myocardial infarction
4.5
7.9
19
43
G63.2
ICD-10 Finland
Diabetic polyneuropathy
13.2
7.9
13
10
E66.01
ICD-10 Finland
Obesity due to excess calories
2.2
7.9
63
293
WZC30
NOMESCO Finland
Teaching
1.8
7.8
122
721
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.2
7.8
31
101
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
7.8
250
1790
RS221, ,
NOMESCO Finland
6.0
7.7
20
34
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.8
7.7
23
62
C07AB02
ATC
metoprolol; systemic
1.7
7.7
169
1101
WX142
NOMESCO Finland
Sub-tenon anesthesy
18.6
7.6
11
6
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
25.3
7.6
10
*
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
4.2
7.6
20
49
ZXE00
NOMESCO Finland
One hour or less
1.5
7.5
284
2104
A10AB06
ATC
insulin glulisine; parenteral
7.2
7.5
17
24
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
7.5
73
367
R4120
NOMESCO Finland
Occupational therapy
2.3
7.5
56
253
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
7.4
212
1472
D31.2
ICD-10 Finland
Benign neoplasm: Retina
80.8
7.4
8
*
BEF00, ,
SPAT
13.5
7.4
12
9
A10BH01
ATC
sitagliptin; oral
2.0
7.3
78
405
321
Kela drug reimbursment
Paricalcitol and cinacalcet
8.5
7.3
15
18
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
7.3
180
1205
JL9AE
NOMESCO Finland
Ultrasound examination of pancreas transplant
+∞
7.3
7
*
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
7.3
7
*
H3603, H350,
ICD-10 Finland
+∞
7.3
7
*
H3602, E113,
ICD-10 Finland
+∞
7.3
7
*
QDH
NOMESCO Finland
Operations on toe nails
+∞
7.3
7
*
H30.8
ICD-10 Finland
Other chorioretinal inflammations
+∞
7.3
7
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
7.3
131
806
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
7.3
117
697
Z2221
NOMESCO Finland
Medical doctor
1.6
7.2
199
1372
SPAT1263
SPAT
Sampling
1.5
7.0
301
2284
I50.0
ICD-10 Finland
Congestive heart failure
2.0
7.0
72
369
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
7.0
152
984
XF402
NOMESCO Finland
ECG with work load test
1.9
7.0
87
477
SPAT1097
SPAT
Recording of ECG
1.8
7.0
114
681
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.2
7.0
57
267
H01.0
ICD-10 Finland
Blepharitis
2.4
7.0
49
215
SPAT1325
SPAT
Vaccination
1.5
7.0
247
1799
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.7
6.9
140
889
S01FA01
ATC
atropine; ophthalmic
13.9
6.9
11
8
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.7
6.9
37
143
K08.3
ICD-10 Finland
Retained dental root
2.1
6.9
61
296
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.2
6.9
58
276
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
40.4
6.8
8
*
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
16.9
6.8
10
6
N03AX16
ATC
[U] pregabalin
1.6
6.7
173
1169
C03AA03
ATC
hydrochlorothiazide; oral
2.0
6.7
76
404
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
6.7
221
1583
R80
ICD-10 Finland
Isolated proteinuria
12.4
6.6
11
9
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
12.4
6.6
11
9
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
12.4
6.6
11
9
Z97.4
ICD-10 Finland
Presence of external hearing-aid
2.3
6.6
48
215
S91.3
ICD-10 Finland
Open wound of other parts of foot
3.1
6.6
27
90
3AC01, ,
NOMESCO Finland
6.9
6.5
15
22
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
5.4
6.5
18
34
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
3.0
6.5
28
96
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.5
324
2528
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.4
494
4185
N08.3
ICD-10 Finland
Glomerular disorders in diabetes mellitus
70.4
6.4
7
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
70.4
6.4
7
*
3643
FHL
Vitrectomy through pars Plana
70.4
6.4
7
*
N18.4
ICD-10 Finland
Chronic kidney disease, stage 4
7.5
6.4
14
19
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
7.5
6.4
14
19
C09BA02
ATC
enalapril and diuretics; systemic
2.0
6.4
69
360
M04AA01
ATC
allopurinol; systemic
1.7
6.4
112
683
H60.9
ICD-10 Finland
Otitis externa, unspecified
2.2
6.4
53
250
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
6.4
212
1517
DFF00
NOMESCO Finland
Pure tone audiometry
1.9
6.4
80
440
TK810
NOMESCO Finland
Hemofiltration
8.2
6.3
13
16
K65.0
ICD-10 Finland
Acute peritonitis
5.6
6.3
17
31
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.1
6.3
60
299
J01DA01
ATC
[U] cefalexin
1.5
6.3
451
3761
A41.8
ICD-10 Finland
Other specified sepsis
3.4
6.3
22
66
SBA00
NOMESCO Finland
Microbiological examinations
3.4
6.3
22
66
PC5DE
NOMESCO Finland
Ultrasound of kidney circulation with Doppler technic
11.1
6.3
11
10
H47.1
ICD-10 Finland
Papilloedema, unspecified
9.4
6.3
12
13
AN1
HP
Coronary angiography
1.8
6.3
96
563
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
18.2
6.3
9
5
H3603, E107,
ICD-10 Finland
+∞
6.3
6
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
6.3
6
*
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
+∞
6.3
6
*
M14.6
ICD-10 Finland
Neuropathic arthropathy
+∞
6.3
6
*
37700
ICD-8 Finland
Other diseases of retina and optic nerve, Haemorrhagia corporis vitrei
+∞
6.3
6
*
H18.2
ICD-10 Finland
Other corneal oedema
26.9
6.2
8
*
Z96.4
ICD-10 Finland
Presence of endocrine implants
26.9
6.2
8
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.9
6.2
29
104
B81
ICPC
Anaemia vit B12/folate deficiency
2.7
6.2
33
127
S92.3
ICD-10 Finland
Fracture of metatarsal bone
2.8
6.2
30
110
WX892
NOMESCO Finland
Monitored bed care
2.0
6.2
65
337
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.1
206
1477
J01MA14
ATC
moxifloxacin; systemic
1.9
6.1
73
395
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.8
6.1
29
105
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
12.6
6.1
10
8
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
6.1
43
190
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.0
6.1
63
325
CBB30
NOMESCO Finland
Excision of lesion of eyelid
3.2
6.1
23
73
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
6.1
84
478
N02AA05
ATC
oxycodone; systemic
1.6
6.0
147
978
S01BA07
ATC
fluorometholone; ophthalmic
5.2
6.0
17
33
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.0
215
1561
K29
ICPC
Cardiovascular sympt/complt other
2.6
6.0
34
135
C07AG02
ATC
carvedilol; oral
2.1
6.0
57
284

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
396
1875
3.22
57.18
6.6
3.7
32.46
7.49
mg/mmol
7.32
291
1224
377
1779
3.13
54.01
5.8
3.1
282.72
228.20
mg/l
0.13
289
1178
385
1884
3.03
50.97
5.8
3.0
6.43
7.70
mmol/l
8.83
335
1592
159
468
4.00
47.78
8.4
3.8
146.08
86.00
ng/l
6.34
148
409
171
550
3.69
45.01
18.0
6.5
13.03
10.19
mmol/l
4.96
163
518
222
903
3.02
39.33
5.3
2.4
2.24
2.30
g/l
0.85
205
831
213
850
3.06
39.00
5.4
2.4
21.48
22.59
%
0.54
175
723
232
974
2.95
38.76
5.3
2.4
11.82
12.84
umol/l
1.29
215
904
204
801
3.08
38.37
17.5
5.1
1.14
1.02
mmol/l
6.26
195
728
156
580
3.10
31.77
8.3
3.4
1.53
2.07
mmol/l
1.13
134
481
155
584
3.06
30.78
8.3
3.4
5.87
5.85
kpa
0.09
148
568
471
3099
2.28
27.66
17.1
6.6
1.21
1.21
mmol/l
0.07
415
2633
525
3704
2.23
24.74
8.7
4.8
7.86
6.70
mmol/l
13.82
500
3471
384
2461
2.09
22.45
3.5
2.2
75.64
77.00
nmol/l
0.48
351
2192
126
503
2.79
22.11
12.0
8.8
—
—
—
0
0
446
3043
2.06
21.74
18.4
16.1
1.32
1.29
inr
0.17
118
882
110
419
2.89
21.02
5.0
3.5
5.02
5.17
kpa
1.41
105
401
108
414
2.86
20.38
5.0
3.5
7.38
7.41
ph
—
9
45
405
2720
2.00
20.06
9.6
4.6
34.92
35.37
g/l
0.85
380
2531
299
1810
2.05
19.80
5.3
4.3
—
—
—
0
0
415
2820
1.99
19.77
13.5
6.0
1.21
1.21
mmol/l
0.09
377
2578
276
1627
2.07
19.62
4.3
2.5
1478.12
8758.02
umol/l
4.03
240
1419
33
54
6.33
19.51
1.1
1.1
—
—
—
0
0
48
111
4.54
19.45
2.0
1.5
—
—
—
0
0
422
2922
1.95
18.64
7.4
5.8
24.27
27.16
%
5.62
395
2743
416
2869
1.95
18.57
7.6
6.0
8.90
8.69
%
0.58
389
2687
606
4776
2.14
18.24
10.8
7.4
87.92
78.10
u/l
2.80
569
4469
33
58
5.89
18.18
2.2
2.3
—
—
—
0
0
414
2878
1.92
17.76
7.1
5.6
60.72
57.58
%
5.38
385
2703
34
63
5.59
17.73
3.0
2.7
1.96
1.08
g/24h
1.52
21
29
411
2854
1.91
17.65
7.3
5.7
2.68
2.88
%
1.06
382
2672
307
1939
1.95
17.53
5.9
3.3
21.97
95.46
e6/l
1.47
255
1511
302
1903
1.95
17.32
3.5
3.1
2198.73
1621.65
ng/l
1.24
257
1622
400
2772
1.89
17.10
7.4
5.7
0.63
0.65
%
0.32
374
2589
303
1922
1.93
16.95
4.0
3.2
—
—
—
0
0
28
20
14.47
16.90
2.5
1.6
—
—
—
0
0
43
103
4.36
16.67
2.0
1.5
122.11
103.35
u/ml
—
9
23
438
3143
1.88
16.62
7.2
5.8
0.20
0.19
e9/l
0.38
382
2765
213
1203
2.05
16.57
4.8
4.1
437.88
322.93
ng/l
0.32
174
983
146
711
2.29
16.56
2.5
1.7
—
—
—
0
0
379
2618
1.86
16.03
2.5
2.0
94.34
94.99
pmol/l
0.08
189
1366
547
4255
1.92
15.71
7.6
4.3
—
—
—
0
0
429
3092
1.84
15.71
7.1
5.6
1.81
1.86
e9/l
0.18
377
2736
113
503
2.45
15.67
5.0
2.6
5.19
4.48
kpa
2.05
108
488
181
984
2.09
15.50
2.5
1.9
29.67
29.69
s
0.01
176
955
247
1505
1.93
15.29
2.8
2.4
—
—
—
0
0
421
3036
1.82
15.21
7.1
5.5
0.04
0.04
e9/l
0.18
361
2629
126
602
2.30
14.86
9.1
4.3
—
—
—
0
0
524
4059
1.86
14.78
6.4
4.6
9028.83
3027.66
e6/l
0.35
12
71
80
309
2.77
14.78
4.8
3.6
—
—
—
0
0
330
2228
1.82
14.66
6.7
3.7
81.58
112.53
e6/l
0.49
260
1624
225
1346
1.94
14.61
4.8
2.6
4.05
5.08
e6/l
1.13
208
1214
302
1991
1.83
14.45
3.1
2.4
—
—
—
0
0
170
925
2.07
14.43
3.2
2.0
—
—
—
0
0
417
3029
1.79
14.42
7.1
5.5
0.64
0.59
e9/l
3.01
356
2617
253
1583
1.88
14.27
2.9
2.1
3.07
3.12
mg/l
0.10
224
1345
396
2851
1.78
13.96
7.6
6.0
—
—
—
0
0
141
724
2.15
13.89
3.6
2.5
1.77
1.79
%
0.11
127
655
180
1013
2.00
13.87
4.3
3.0
2.48
1.89
e6/l
0.46
110
569
179
1014
1.99
13.50
3.6
3.2
0.83
0.81
mmol/l
0.57
163
955
112
530
2.30
13.46
3.4
2.6
67.62
69.47
e9/l
0.23
91
417
77
307
2.67
13.36
2.0
2.1
1.55
1.50
g/l
0.17
68
273
284
1875
1.80
13.28
2.6
2.1
353.39
306.82
u/l
0.17
268
1770
364
2583
1.76
13.28
5.1
2.8
150.54
140.68
ug/l
0.35
340
2370
46
140
3.43
12.77
5.1
2.3
—
—
—
0
0
116
570
2.21
12.71
2.4
2.5
5.59
7.13
ug/l
0.78
103
497
39
108
3.75
12.45
1.5
1.1
306.73
270.21
u/ml
0.27
22
64
49
160
3.20
12.17
2.8
2.3
307.60
87.41
ug/min
1.35
33
95
95
438
2.33
12.09
1.8
2.7
—
—
—
0
0
266
1764
1.76
12.01
5.1
3.2
0.39
0.48
e6/l
0.32
220
1345
41
121
3.52
11.93
2.8
2.3
120.23
127.68
g/l
1.06
30
90
37
102
3.76
11.90
6.4
2.5
—
—
—
0
0
109
536
2.20
11.89
2.3
2.8
66.68
66.36
g/l
0.17
99
489
209
1296
1.83
11.79
5.0
2.9
481.15
554.37
mosm/kgh2o
6.39
185
1110
660
5665
1.98
11.71
10.4
5.7
46.36
39.81
mmol/mol
24.32
605
5247
275
1854
1.74
11.65
9.9
4.1
7.39
7.40
ph
1.02
45
359
66
263
2.65
11.46
5.0
4.1
24.04
25.14
mmol/l
2.51
61
248
388
2880
1.68
11.45
3.4
2.6
—
—
—
0
0
429
3281
1.67
11.19
6.3
6.1
11.12
11.80
umol/l
0.62
401
3124
180
1081
1.86
11.19
3.9
2.8
1.23
1.01
e6/l
0.27
114
630
18
13
14.13
11.00
6.3
6.0
—
—
—
0
0
77
341
2.39
10.72
10.8
10.4
—
—
—
0
0
124
666
2.02
10.70
9.5
8.1
95.54
95.38
%
0.11
115
645
454
3548
1.65
10.68
8.9
8.8
4.50
4.17
e9/l
2.03
392
3121
553
4553
1.71
10.59
5.9
4.0
17.28
12.54
mm/h
7.85
509
4178
14
6
23.71
10.26
2.0
1.7
142.00
89.17
ng/l
—
14
6
713
6365
2.18
10.26
32.4
17.4
4.04
3.99
mmol/l
4.93
696
6178
132
738
1.95
10.13
9.6
7.8
4.93
5.11
kpa
1.31
118
708
132
739
1.94
10.09
9.5
7.8
12.45
12.01
kpa
0.33
119
711
695
6158
2.03
10.02
26.6
14.9
26.07
25.10
mg/l
0.34
606
4917
711
6352
2.14
10.02
31.8
17.3
139.24
139.64
mmol/l
3.77
696
6175
58
232
2.62
10.00
5.3
3.2
0.46
0.24
g/l
1.54
33
91
47
169
2.89
9.92
1.4
1.2
—
—
—
0
0
57
228
2.62
9.83
1.8
2.8
10.02
10.10
g/l
0.04
52
205
250
1708
1.68
9.76
4.9
3.2
—
—
—
0
0
194
1237
1.75
9.74
1.7
1.7
1136.59
1183.96
nmol/l
0.26
145
930
135
782
1.88
9.27
1.5
1.3
607.69
486.55
titre
0.24
26
165
106
567
2.00
9.21
4.0
3.2
375.35
224.14
ng/l
1.37
96
526
114
630
1.95
9.02
2.8
1.5
—
—
—
0
0
128
739
1.87
8.87
9.7
7.8
0.61
1.38
mmol/l
1.50
98
580
53
216
2.56
8.82
2.3
3.7
53.72
86.34
mg/l
0.54
47
173
53
216
2.56
8.82
2.3
3.7
38.64
31.27
mg/l
0.58
47
172
90
464
2.06
8.64
2.9
2.6
11.24
10.60
g/l
0.56
80
422
200
1326
1.68
8.59
1.8
1.7
1.19
1.24
mg/l
0.12
166
1030
227
1559
1.64
8.49
5.1
3.9
90.14
88.42
%
0.41
222
1524
76
371
2.16
8.41
2.1
1.8
1.14
1.55
g/l
0.97
66
338
333
2513
1.56
8.33
4.9
3.7
228.08
45.75
ng/l
0.61
269
1775
260
1854
1.60
8.31
5.0
4.0
—
—
—
0
0
61
273
2.34
8.31
6.7
5.2
1.42
1.59
%
0.92
52
260
14
12
11.85
8.09
1.1
1.0
—
—
—
0
0
23
60
3.92
8.02
1.1
1.2
—
—
—
0
0
107
605
1.89
7.88
11.0
8.6
114.67
120.82
g/l
1.80
99
593
21
52
4.12
7.84
3.1
1.6
10.81
10.86
%
0.02
21
52
226
1577
1.61
7.83
1.8
1.6
1.29
1.36
mmol/l
0.74
195
1337
14
13
10.94
7.81
1.0
1.0
—
—
—
0
0
269
1969
1.55
7.53
5.4
2.5
57.26
62.41
u/l
0.62
247
1827
26
78
3.41
7.44
1.0
1.1
43.85
85.29
iu/ml
—
6
21
96
535
1.90
7.38
2.0
1.9
387.56
379.81
nmol/l
0.13
88
486
58
270
2.24
7.22
7.0
5.3
0.85
0.90
%
0.37
48
257
316
2413
1.51
7.21
4.7
3.4
6.21
5.81
ph
1.22
19
182
272
2015
1.53
7.14
3.8
3.1
46.22
35.39
u/l
0.49
261
1916
628
5569
1.61
6.84
5.7
4.5
1.94
2.15
mu/l
0.44
568
5067
374
2986
1.48
6.71
5.6
3.7
0.00
0.00
estimate
0.50
63
612
374
3007
1.46
6.36
5.9
3.7
0.00
0.01
estimate
0.50
55
551
47
212
2.29
6.32
2.1
1.9
22.49
21.27
s
0.61
47
192
12
13
9.35
6.30
1.0
1.0
—
—
—
0
0
90
517
1.84
6.29
3.9
3.9
1.04
0.89
%
0.12
39
188
119
743
1.71
6.26
2.7
1.6
—
—
—
0
0
85
481
1.86
6.23
4.0
4.0
0.06
0.13
%
0.74
34
151
31
116
2.74
6.15
4.5
2.4
—
—
—
0
0
10
8
12.64
6.09
14.7
6.1
4.98
6.81
mmol/l
—
10
8
44
197
2.31
6.03
2.0
3.0
38.22
37.68
g/l
0.28
38
175
57
285
2.08
5.97
2.2
1.8
3.16
1.45
ug/l
0.70
47
250
708
6532
1.77
5.96
15.8
10.2
26.60
26.82
u/l
0.09
678
6285
164
1125
1.58
5.93
1.7
1.4
2.87
2.49
g/l
1.06
96
691
38
162
2.41
5.81
2.8
2.2
12.71
11.76
mg/l
0.24
30
145
30
114
2.70
5.79
2.1
1.8
4.01
4.95
mmol/24h
0.90
25
99
179
1262
1.54
5.72
1.4
1.2
1.76
1.36
u/ml
0.21
47
340
46
216
2.20
5.65
8.1
6.4
1.60
1.38
mmol/l
0.56
40
191
137
911
1.61
5.63
2.8
1.8
—
—
—
0
0
211
1548
1.49
5.57
1.8
1.6
18.84
20.24
nmol/l
0.85
183
1319
37
160
2.38
5.50
2.1
3.7
—
—
—
0
0
365
2976
1.42
5.49
7.9
5.0
0.00
0.00
estimate
0.50
60
564
71
397
1.87
5.42
5.2
3.2
—
—
—
0
0
218
1621
1.48
5.36
1.4
1.4
—
—
—
0
0
22
75
2.99
5.18
1.4
1.6
59.40
65.54
%
0.28
15
54
21
72
2.97
4.90
2.0
1.2
0.65
0.56
nmol/l
0.47
21
67
268
2101
1.42
4.90
4.6
3.3
2.35
2.35
mmol/l
0.18
240
1838
726
6812
1.77
4.88
38.0
21.8
38.69
40.16
%
6.24
669
6339
519
4550
1.41
4.87
4.4
3.7
14.88
14.86
pmol/l
0.07
467
4116
726
6813
1.77
4.86
37.5
21.7
248.45
245.98
e9/l
0.47
711
6629
77
457
1.76
4.85
4.2
4.0
0.04
0.13
%
0.58
27
127
726
6814
1.76
4.84
37.4
21.6
90.79
91.23
fl
1.88
715
6700
726
6815
1.76
4.83
37.3
21.6
30.12
30.38
pg
3.67
715
6700
726
6816
1.76
4.81
37.5
21.7
7.18
6.75
e9/l
3.39
711
6612
726
6816
1.76
4.81
37.5
21.7
4.39
4.48
e12/l
4.47
711
6613
726
6817
1.76
4.79
37.7
21.8
130.96
135.35
g/l
9.92
715
6701
671
6184
1.55
4.74
6.6
4.8
2.44
2.72
mmol/l
12.45
619
5674
20
68
2.99
4.74
2.0
1.2
—
—
—
0
0
77
461
1.74
4.71
3.9
3.8
0.95
0.57
%
0.33
32
154
93
587
1.66
4.69
3.2
2.1
0.21
0.21
g/l
0.02
88
545
58
319
1.88
4.68
2.6
2.4
—
—
—
0
0
24
92
2.66
4.60
1.2
1.4
31.27
29.97
g/l
0.16
19
79
19
64
3.02
4.58
1.5
2.7
—
—
—
0
0
125
860
1.54
4.41
1.3
1.2
—
—
—
0
0
66
387
1.77
4.35
1.6
1.5
—
—
—
0
0
73
445
1.71
4.21
1.2
1.2
—
—
—
0
0
633
5804
1.45
4.20
5.5
3.9
1.40
1.29
mmol/l
2.77
583
5307
200
1525
1.42
4.18
6.4
6.6
—
—
—
0
0
36
174
2.12
4.17
1.7
1.4
291.04
297.35
ug/g
0.07
25
101
651
6009
1.46
4.09
6.2
4.3
1.37
1.44
mmol/l
4.80
604
5520
325
2695
1.35
4.03
13.0
9.5
0.00
0.00
e9/l
0.73
245
2212
654
6055
1.45
3.92
6.1
4.3
4.28
4.59
mmol/l
12.77
610
5591
11
23
4.83
3.88
3.2
1.9
—
—
—
0
0
30
139
2.20
3.87
4.9
3.8
—
—
—
0
0
24
101
2.42
3.85
1.2
1.4
—
—
—
0
0
108
744
1.52
3.79
1.8
1.4
—
—
—
0
0
105
721
1.53
3.74
2.4
2.5
8.18
9.32
umol/l
0.21
90
629
11
25
4.45
3.63
1.5
1.6
40.09
59.51
ug/l
1.06
11
25
13
35
3.76
3.60
2.7
2.1
—
—
—
0
0
21
86
2.48
3.57
1.8
1.9
0.54
0.88
g/l
0.64
14
66
290
2399
1.33
3.55
2.3
2.1
—
—
—
0
0
63
388
1.68
3.52
12.3
10.0
93.83
94.14
%
0.15
63
383
80
525
1.58
3.48
1.5
1.4
—
—
—
0
0
23
100
2.34
3.46
1.6
1.2
—
—
—
0
0
18
70
2.61
3.40
2.1
2.2
—
—
—
0
0
31
154
2.05
3.39
10.1
6.8
12.96
11.21
mmol/l
1.51
23
143
31
154
2.05
3.39
10.1
6.8
104.04
105.35
mmol/l
0.48
23
143
453
4007
1.30
3.34
4.2
3.1
63.38
49.72
u/l
2.06
415
3729
56
341
1.69
3.28
1.2
1.2
—
—
—
0
0
44
251
1.80
3.23
2.0
1.8
—
—
—
0
0
84
569
1.53
3.20
4.2
2.3
45.98
34.47
u/l
0.63
65
484
8
15
5.38
3.19
1.3
1.1
—
—
—
0
0
7
11
6.41
3.19
1.3
1.6
—
—
—
0
0
7
11
6.41
3.19
1.4
1.3
—
—
—
0
0
13
40
3.29
3.15
2.7
3.1
—
—
—
0
0
174
1357
1.36
3.11
4.7
3.6
—
—
—
0
0
19
80
2.41
3.08
1.2
1.3
1868.78
1346.47
e6/l
—
9
55
8
16
5.04
3.05
1.0
1.4
—
—
—
0
0
679
6409
1.41
2.94
25.7
14.1
—
—
—
0
0
206
1664
1.32
2.89
5.8
3.4
—
—
—
0
0
571
5263
1.30
2.82
31.0
17.7
15.51
15.03
%
0.97
564
5169
23
111
2.10
2.75
1.3
1.2
—
—
—
0
0
30
160
1.91
2.74
1.4
1.6
13898.86
15855.81
e6/l
0.12
22
118
29
153
1.93
2.74
1.7
1.2
1.67
11.29
u/ml
—
6
29
61
400
1.57
2.71
4.0
3.0
5.06
7.51
e9/l
0.74
45
327
12
40
3.03
2.70
2.0
1.2
—
—
—
0
0
55
352
1.60
2.70
1.5
1.4
—
54.29
—
0
24
23
112
2.09
2.69
1.3
1.4
—
—
—
0
0
24
119
2.05
2.68
1.3
1.5
—
—
—
0
0
17
73
2.36
2.66
1.8
4.1
—
—
—
0
0
11
35
3.17
2.65
3.4
1.5
10.09
10.07
mmol/l
0.01
11
35
28
148
1.92
2.63
1.6
1.7
—
—
—
0
0
15
62
2.45
2.55
4.7
2.5
—
—
—
0
0
15
321
0.46
2.44
1.2
1.4
—
—
—
0
0
50
321
1.60
2.44
6.5
3.7
—
—
—
0
0
32
182
1.79
2.43
5.8
4.5
—
—
—
0
0
62
419
1.52
2.43
11.4
7.0
23.44
24.42
mmol/l
1.29
53
402
48
306
1.61
2.42
3.1
3.3
4.06
4.50
pmol/l
2.56
39
269
28
153
1.86
2.41
1.7
1.2
1.26
2.74
u/ml
—
5
21
15
64
2.37
2.40
1.2
1.3
—
—
—
0
0
9
27
3.36
2.39
2.9
3.7
547.56
1081.56
u/ml
—
9
27
169
1365
1.30
2.35
1.7
1.7
437.35
11511854.50
pmol/l
0.73
142
1138
9
28
3.24
2.31
7.2
14.8
—
—
—
0
0
178
2150
0.78
2.28
3.9
2.8
—
—
—
0
0
15
66
2.30
2.25
1.7
1.2
—
—
nmol/l
—
0
0
10
35
2.88
2.21
1.5
1.8
45.19
36.84
%
—
10
35
8
24
3.36
2.18
9.8
3.3
—
—
—
0
0
16
74
2.19
2.16
1.3
1.3
70619.20
37513.11
e6/l
—
5
44
6
14
4.31
2.15
1.2
1.5
—
—
—
0
0
92
690
1.38
2.11
1.4
1.3
—
—
—
0
0
5
10
5.02
2.07
1.6
1.3
91.60
57.10
nmol/24h
—
5
10
25
139
1.82
2.07
5.1
2.6
—
—
—
0
0
59
410
1.47
2.06
2.6
1.6
—
—
—
0
0
12
50
2.42
2.03
1.3
1.2
5.92
6.54
g/l
—
7
35
12
50
2.42
2.03
1.3
1.2
2.81
2.82
g/l
—
7
35
12
50
2.42
2.03
1.3
1.2
0.42
0.36
g/l
—
7
34
20
104
1.95
2.02
1.4
1.5
—
—
—
0
0
11
44
2.52
2.02
1.4
1.1
—
—
—
0
0
24
133
1.83
2.01
3.5
2.4
15.04
15.73
%
0.56
19
59
12
51
2.37
1.95
1.3
1.2
—
—
—
0
0
10
39
2.58
1.94
1.9
3.4
—
—
—
0
0
6
16
3.77
1.93
1.3
1.1
—
—
—
0
0
6
16
3.77
1.93
1.3
1.1
—
—
—
0
0
6
16
3.77
1.93
1.3
1.1
—
—
—
0
0
15
71
2.13
1.93
1.2
1.2
—
—
—
0
0
19
99
1.94
1.91
2.9
2.5
104.58
105.38
mmol/l
0.28
19
99
19
99
1.94
1.91
2.9
2.5
4.11
4.09
mmol/l
0.06
19
99
15
72
2.10
1.87
1.2
1.6
—
—
—
0
0
8
29
2.78
1.79
1.4
3.8
62.00
139.55
nmol/l
—
8
29
23
131
1.78
1.79
1.8
1.7
2.44
5.50
iu/l
—
7
34
11
47
2.36
1.78
1.5
1.2
—
—
—
0
0
6
18
3.35
1.75
1.2
1.2
—
—
—
0
0
7
25
2.82
1.65
1.6
1.4
—
1.00
—
0
5
549
5164
1.20
1.65
33.3
19.1
330.72
332.47
g/l
3.95
542
5119
69
517
1.37
1.63
6.9
3.3
—
—
—
0
0
60
440
1.39
1.61
8.1
4.8
—
—
—
0
0
10
43
2.34
1.59
1.3
1.2
—
—
—
0
0
18
99
1.84
1.58
3.0
2.5
—
—
—
0
0
14
71
1.99
1.54
1.0
1.1
2.06
0.95
u/ml
—
6
32
627
5988
1.22
1.54
6.1
4.6
6.83
5.97
mmol/l
15.66
560
5440
5
15
3.35
1.52
1.6
1.5
—
—
—
0
0
6
21
2.87
1.51
1.2
1.6
—
—
—
0
0
31
202
1.56
1.50
1.3
1.1
—
—
—
0
0
14
72
1.96
1.49
1.0
1.1
7.82
6.31
u/ml
—
8
37
14
72
1.96
1.49
1.4
1.4
—
—
—
0
0
7
28
2.51
1.45
1.0
1.1
97.00
172.20
mmol/24h
—
7
28
11
52
2.13
1.45
2.4
1.2
—
—
—
0
0
11
52
2.13
1.45
1.5
1.4
35.00
28.99
%
—
5
35
5
16
3.14
1.44
1.8
1.9
—
—
—
0
0
9
40
2.26
1.40
1.1
1.1
57.00
39.15
mg/l
—
9
33
24
154
1.58
1.27
1.4
1.2
6.43
8.37
u/l
0.46
18
122
6
25
2.41
1.24
1.0
1.1
1788.50
1529.80
miu/ml
—
6
25
157
1353
1.20
1.23
6.7
4.0
1.02
1.02
kg/l
0.08
37
200
85
687
1.27
1.22
3.1
2.4
265.85
137.29
ug/g
1.12
67
562
66
518
1.30
1.19
8.4
4.0
1.23
1.23
mmol/l
0.08
60
457
6
26
2.32
1.19
2.2
3.5
25.17
29.47
umol/l
—
6
19
117
986
1.22
1.16
1.3
1.3
29.21
37.52
iu/ml
0.54
38
318
15
87
1.74
1.15
1.1
1.1
—
17.53
—
0
6
8
39
2.06
1.15
1.4
1.6
—
—
—
0
0
8
153
0.52
1.15
1.3
1.2
—
—
—
0
0
112
945
1.22
1.10
1.3
1.2
13.89
11.32
u/ml
0.15
33
369
7
32
2.20
1.08
3.7
6.7
—
—
—
0
0
185
1638
1.17
1.07
6.3
3.9
0.00
0.01
estimate
0.88
54
546
15
90
1.68
1.04
1.2
1.1
—
—
—
0
0
9
46
1.97
1.04
1.2
1.1
—
—
—
0
0
7
35
2.01
1.00
1.3
1.8
—
—
—
0
0
13
76
1.72
0.99
1.4
1.3
—
—
—
0
0
5
23
2.18
0.98
1.0
1.4
—
—
—
0
0
9
50
1.81
0.97
1.3
1.5
89.89
79.54
umol/l
—
9
50
28
199
1.42
0.97
1.4
1.3
14.18
25.26
iu/l
1.83
23
169
461
4369
1.13
0.96
4.5
3.9
—
—
—
0
0
24
166
1.46
0.95
1.0
1.2
—
—
—
0
0
262
2403
1.13
0.92
4.3
5.0
8.53
2.39
ug/l
0.73
234
2143
14
86
1.64
0.91
1.1
1.0
—
—
—
0
0
10
56
1.80
0.88
1.2
1.1
—
—
—
0
0
134
1177
1.17
0.87
3.0
3.0
2.47
2.45
mmol/l
1.10
115
1030
40
512
0.77
0.86
1.4
1.4
—
—
—
0
0
15
98
1.54
0.79
1.2
1.5
—
—
—
0
0
26
191
1.37
0.78
1.1
1.1
—
—
—
0
0
19
132
1.45
0.76
1.8
2.0
1902.30
3152.91
u/l
—
7
50
43
343
1.27
0.75
1.3
1.2
113.01
215.67
u/ml
1.21
38
314
69
581
1.21
0.74
1.6
1.4
—
—
—
0
0
24
176
1.37
0.73
5.6
3.3
—
—
—
0
0
5
25
2.01
0.72
1.8
2.8
37380.00
34768.20
ug/l
—
5
25
13
84
1.56
0.72
1.0
1.2
0.45
2.61
u/ml
—
7
46
123
1380
0.87
0.71
3.0
3.1
0.82
0.77
ug/l
0.27
84
907
43
528
0.80
0.69
5.9
3.7
—
—
—
0
0
45
367
1.24
0.67
1.3
1.2
163.23
128.32
iu/ml
0.15
12
142
7
44
1.60
0.65
1.3
1.5
139.03
166.82
pmol/l
—
7
44
20
269
0.74
0.64
1.9
1.6
—
—
—
0
0
11
71
1.56
0.62
1.0
1.1
0.15
1.08
u/ml
—
5
35
16
113
1.42
0.61
1.9
2.5
—
—
—
0
0
9
140
0.64
0.61
2.0
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
52.59
—
0
8
35
282
1.25
0.59
2.4
2.9
—
—
—
0
0
8
53
1.51
0.58
1.1
1.2
—
—
—
0
0
8
55
1.46
0.56
1.5
1.3
—
—
—
0
0
45
378
1.20
0.53
1.3
1.3
—
—
—
0
0
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
6
39
1.54
0.53
9.2
3.4
—
—
—
0
0
16
117
1.38
0.52
3.0
3.6
3.91
4.29
e9/l
0.51
16
117
24
188
1.29
0.51
2.0
1.6
—
—
—
0
0
9
64
1.41
0.51
1.1
1.3
—
—
—
0
0
16
118
1.36
0.50
2.9
4.0
56.75
58.84
%
0.49
16
118
18
137
1.32
0.47
6.4
4.1
20.47
30.88
mg/l
1.24
11
91
54
469
1.16
0.46
1.4
1.4
—
—
—
0
0
8
58
1.38
0.41
1.5
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
16.81
—
0
15
8
59
1.36
0.41
8.3
3.4
—
—
—
0
0
58
512
1.14
0.41
2.2
2.2
12.69
12.89
nmol/l
0.06
52
469
49
428
1.15
0.40
1.4
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
341.75
—
0
12
11
80
1.38
0.38
1.3
1.2
—
—
—
0
0
5
37
1.35
0.37
1.0
1.0
—
—
—
0
0
11
82
1.35
0.34
1.4
1.1
—
—
—
0
0
15
188
0.79
0.33
1.4
1.5
—
—
—
0
0
7
54
1.30
0.30
1.3
1.1
—
—
—
0
0
12
94
1.28
0.28
1.4
2.0
—
—
—
0
0
10
128
0.78
0.27
1.3
1.3
—
—
—
0
0
19
160
1.19
0.25
1.0
1.1
—
—
—
0
0
16
190
0.84
0.23
1.4
1.4
—
—
—
0
0
10
125
0.80
0.23
1.1
1.8
—
—
—
0
0
16
189
0.84
0.22
1.4
1.4
—
—
—
0
0
16
188
0.85
0.21
1.4
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.2
1.2
—
—
—
0
0
15
176
0.85
0.20
1.4
1.4
—
—
—
0
0
26
231
1.13
0.20
1.0
1.1
—
—
—
0
0
18
207
0.87
0.19
13.8
9.2
—
—
—
0
0
6
53
1.13
0.18
1.0
1.5
—
—
—
0
0
17
147
1.16
0.18
3.6
4.5
2.20
2.63
mmol/l
0.41
12
101
9
83
1.09
0.14
1.3
1.8
29.44
32.57
pg
—
9
83
69
658
1.05
0.13
3.0
4.2
139.82
18.00
ug/l
0.43
56
562
27
254
1.07
0.08
8.0
4.6
—
—
—
0
0
6
72
0.83
0.07
1.5
1.5
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
13
143
0.91
0.07
1.5
1.5
—
—
—
0
0
7
83
0.84
0.07
1.0
1.2
—
—
—
0
0
83
808
1.03
0.07
1.3
1.3
—
—
—
0
0
9
84
1.07
0.07
1.2
1.1
—
—
—
0
0
9
84
1.07
0.07
1.2
1.1
—
—
—
0
0
9
87
1.03
0.07
1.1
1.7
—
—
—
0
0
11
119
0.92
0.04
1.4
1.2
—
—
—
0
0
26
255
1.02
0.00
1.1
1.2
—
—
—
0
0
10
102
0.98
0.00
2.1
2.7
—
—
—
0
0
63
634
0.99
0.00
1.4
1.6
—
—
—
0
0
19
188
1.01
0.00
1.5
1.8
39.42
39.88
nmol/l
0.03
19
182
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
69
0.87
-0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
183.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
13.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
69
0.87
-0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_BCKRNDRETINOPAT and mortality.

Females

Parameter HR [95% CI] p-value
H7_BCKRNDRETINOPAT 1.398 [1.23, 1.59] < 0.001
Birth year 0.998 [0.99, 1.01] 0.678

During the follow-up period (1.1.1998 — 31.12.2019), 810 out of 2446 females with H7_BCKRNDRETINOPAT died.

Males

Parameter HR [95% CI] p-value
H7_BCKRNDRETINOPAT 1.353 [1.17, 1.56] < 0.001
Birth year 0.99 [0.98, 1.0] 0.037

During the follow-up period (1.1.1998 — 31.12.2019), 716 out of 2418 males with H7_BCKRNDRETINOPAT died.

Mortality risk

Mortality risk for people of age

years, who have H7_BCKRNDRETINOPAT.

N-year risk Females Males
1 0.149% 0.271%
5 0.836% 1.616%
10 2.152% 4.152%
15 4.438% 7.965%
20 7.889% 13.748%

Relationships between endpoints

Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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