cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.
Vascular syndromes of brain in cerebrovascular disorders
DOID EFO Endpoint Browser PheWeb
I9_VASCSYND
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1665 |
4. Check minimum number of eventsNone |
1665 |
5. Include endpointsNone |
1665 |
6. Filter based on genotype QC (FinnGen only) |
1665 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Vascular syndromes of brain in cerebrovascular disorders
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16266 | 7420 | 8756 |
| Only index persons | 13791 | 6353 | 7438 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.23 | 0.21 | 0.24 |
| Only index persons | 0.26 | 0.23 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 72.14 | 75.72 | 69.09 |
| Only index persons | 71.24 | 74.84 | 68.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1665 | 690 | 975 |
| Unadjusted period prevalence (%) | 0.35 | 0.24 | 0.43 |
| Median age at first event (years) | 68.45 | 67.20 | 69.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1484
- Matched controls
- 14841
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
+∞
323.0
396
*
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
3822.1
323.0
535
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
12.1
283.6
581
748
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
9.1
263.9
662
1204
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
79.1
257.2
288
45
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
9.4
189.8
436
630
G46.4
ICD-10 Finland
Cerebellar stroke syndrome
1700.1
157.1
150
*
B01AC04
ATC
clopidogrel; oral
4.8
145.5
615
1890
AA1AD
NOMESCO Finland
CT of head and brain
4.3
138.6
709
2599
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
287.1
130.4
131
5
G46.7*I67.9
ICD-10 Finland
Other lacunar syndromes
1185.4
114.2
110
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
8.5
108.7
255
354
G46.3
ICD-10 Finland
Brain stem stroke syndrome
+∞
103.3
98
*
R42
ICD-10 Finland
Dizziness and giddiness
3.5
91.0
564
2229
N06DX01
ATC
memantine; oral
50.5
89.5
108
23
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
7.0
80.0
211
342
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
79.9
76
*
K90
ICPC
Stroke/cerebrovascular accident
8.2
68.5
161
218
G30.1
ICD-10 Finland
Alzheimer disease with late onset
29.8
66.6
90
32
N06DA02
ATC
donepezil; oral
38.6
66.1
84
23
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.1
64.1
282
805
G46.8
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
+∞
57.7
55
*
C10AA01
ATC
simvastatin; oral
2.4
55.0
901
5849
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.4
53.8
214
550
F03
ICD-10 Finland
Unspecified dementia
15.4
53.3
89
61
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
52.9
417
1815
C10AA05
ATC
atorvastatin; oral
2.3
50.9
768
4714
N06DA03
ATC
rivastigmine; oral, transdermal
44.5
48.8
60
14
XA800
NOMESCO Finland
Neuropsychological investigation
7.6
48.2
117
165
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
45.7
183
470
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
84.5
44.1
49
6
G46.7
ICD-10 Finland
Other lacunar syndromes
+∞
44.0
42
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
5.9
43.4
127
231
P20
ICPC
Memory disturbance
3.1
42.4
270
1006
G46.0*I66.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
41.9
40
*
B01AA03
ATC
warfarin; systemic
2.2
38.5
522
2931
B01AC07
ATC
dipyridamole; systemic
3.5
38.3
195
614
G46.5*I67.9
ICD-10 Finland
Pure motor lacunar syndrome
+∞
37.7
36
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
37.5
1047
7909
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.3
36.8
204
684
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
6.5
33.8
90
145
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
30.2
33.1
44
15
F01.9
ICD-10 Finland
Vascular dementia, unspecified
30.2
33.1
44
15
I63.8
ICD-10 Finland
Other cerebral infarction
11.5
32.4
61
55
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
4.3
30.9
120
297
G30.8
ICD-10 Finland
Other Alzheimer disease
39.0
30.3
38
10
315
Kela drug reimbursment
Clopidogrel
9.2
30.3
64
72
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
6.7
30.2
79
124
G46.6*I67.9
ICD-10 Finland
Pure sensory lacunar syndrome
+∞
29.3
28
*
N06DA04
ATC
galantamine; oral
67.3
29.0
33
5
A28
ICPC
Limited function/disability NOS
2.3
28.6
321
1615
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
28.3
329
1682
N05AX08
ATC
risperidone; systemic
3.9
27.9
122
337
N02BE01
ATC
paracetamol; systemic, rectal
2.1
26.9
1239
10497
SPAT1053
SPAT
Memory test
2.2
26.8
313
1599
R53
ICD-10 Finland
Malaise and fatigue
2.1
26.4
347
1867
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
25.5
137
446
G46.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
25.1
24
*
R51.80
ICD-10 Finland
Headache
2.5
24.7
216
952
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
24.4
496
3140
SPAT1216
SPAT
Assessment of functional ability
2.2
24.0
292
1510
P70
ICPC
Dementia
13.6
23.8
41
31
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
23.7
370
2122
C09AA05
ATC
ramipril; oral
1.9
23.5
488
3104
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
+∞
23.0
22
*
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
9.1
22.9
48
54
K91
ICPC
Cerebrovascular disease
6.8
22.4
57
87
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.0
22.0
135
481
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.7
21.7
76
170
SPAT1301
SPAT
No procedures
1.8
21.4
499
3273
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.4
21.2
105
321
205
Kela drug reimbursment
Chronic hypertension
1.7
21.0
583
4035
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
10.8
20.9
40
38
G46.2*I66.2
ICD-10 Finland
Posterior cerebral artery syndrome
+∞
20.9
20
*
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
19.8
20.9
31
16
C10AA07
ATC
rosuvastatin; oral
1.9
20.8
394
2404
C10AX09
ATC
ezetimibe; oral
2.3
20.6
206
969
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
20.5
472
3072
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
20.2
148
587
C08CA01
ATC
amlodipine; oral
1.7
19.9
632
4527
I63
ICD-10 Finland
Cerebral infarction
9.0
19.9
42
48
N18
ICPC
Paralysis/weakness
5.0
19.0
62
129
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
+∞
18.8
18
*
G46.5
ICD-10 Finland
Pure motor lacunar syndrome
+∞
18.8
18
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
18.8
240
1256
SPAT1229
SPAT
Assessment of need for aid
2.5
18.7
161
701
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
18.6
142
579
I95.1
ICD-10 Finland
Orthostatic hypotension
3.5
18.2
86
254
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
9.9
18.2
36
37
AAF00
NOMESCO Finland
Ventriculostomy
11.6
18.0
33
29
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.2
17.4
92
297
N06AX11
ATC
mirtazapine; oral
1.7
17.3
406
2637
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
16.7
100
350
N06AB10
ATC
escitalopram; oral
2.0
15.8
215
1149
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
15.7
148
674
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
7.7
15.7
36
48
A10AE04
ATC
insulin glargine; parenteral
2.2
15.5
168
817
SPAT1254
SPAT
Administration of medicine
1.9
15.5
242
1365
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.8
15.5
66
180
G44.2
ICD-10 Finland
Tension-type headache
2.1
15.4
175
869
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
15.3
105
400
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
14.9
189
981
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
4.8
14.9
49
104
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.6
14.7
66
188
S06.0
ICD-10 Finland
Concussion
2.3
14.6
147
691
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
14.6
429
2945
PA7BD
NOMESCO Finland
CT angiography of neck and brain
4.8
14.5
48
103
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
14.4
422
2894
G81.9
ICD-10 Finland
Hemiplegia, unspecified
7.2
14.3
34
48
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.2
14.0
146
696
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
8.9
14.0
29
33
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.4
14.0
126
562
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
13.8
169
866
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
13.7
243
1429
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
13.6
121
535
R41.3
ICD-10 Finland
Other amnesia
4.0
13.4
53
136
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
13.3
278
1722
C03CA01
ATC
furosemide; systemic
1.5
13.2
575
4326
C07AB07
ATC
bisoprolol; oral
1.5
13.1
786
6346
J01MA02
ATC
ciprofloxacin; systemic
1.5
13.1
582
4399
R20.2
ICD-10 Finland
Paraesthesia of skin
2.6
13.0
96
384
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
13.0
247
1484
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
12.7
297
1901
G30
ICD-10 Finland
Alzheimer disease
32.3
12.6
16
5
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
12.6
453
3252
SPAT1263
SPAT
Sampling
1.5
12.5
581
4424
J01DB01
ATC
cefalexin; oral
1.5
12.4
1082
9433
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.4
12.4
44
102
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.7
12.4
88
343
N03AX12
ATC
gabapentin; oral
1.8
12.4
221
1301
N03AG01
ATC
valproic acid; systemic, rectal
2.8
12.2
79
292
H53.4
ICD-10 Finland
Visual field defects
4.0
12.1
47
119
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.0
12.0
151
782
N05AH04
ATC
quetiapine; oral
2.0
11.9
164
878
G43.9
ICD-10 Finland
Migraine, unspecified
3.6
11.8
53
152
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
11.8
395
2776
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
10.6
11.8
22
21
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
4.5
11.7
41
94
SPAT1101
SPAT
Orthostatic test
2.5
11.7
89
364
280
Kela drug reimbursment
Clopidogrel
3.7
11.7
50
138
R4120
NOMESCO Finland
Occupational therapy
2.4
11.7
98
422
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
11.6
219
1309
G91.1
ICD-10 Finland
Obstructive hydrocephalus
12.6
11.6
20
16
R11
ICD-10 Finland
Nausea and vomiting
2.2
11.5
119
565
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
11.5
11
*
R41.0
ICD-10 Finland
Disorientation, unspecified
3.1
11.5
61
200
H53.2
ICD-10 Finland
Diplopia
3.3
11.3
57
180
SPAT1252
SPAT
Overall medication plan or its review
2.2
11.2
120
580
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.9
11.2
178
1005
SPAT1234
SPAT
Support of social functional capacity
2.5
11.2
86
354
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
4.8
11.1
36
77
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.4
11.1
32
60
R55
ICD-10 Finland
Syncope and collapse
1.9
11.0
178
1013
AA5PD
NOMESCO Finland
CT examination of brain pefusion
6.3
10.9
28
45
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
10.8
431
3148
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
10.7
673
5397
C01DA14
ATC
isosorbide mononitrate; oral
1.6
10.7
343
2375
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
5.0
10.7
33
67
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.3
10.5
102
471
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
5.4
10.4
30
56
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
10.4
427
3131
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
10.4
10
*
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
10.4
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
10.4
211
1290
F01.2
ICD-10 Finland
Subcortical vascular dementia
32.7
10.3
13
*
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
10.3
512
3909
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.9
10.3
161
903
WYA20
NOMESCO Finland
Home visit
5.6
10.3
29
53
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.2
10.3
108
516
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
18.9
10.3
15
8
AN1
HP
Coronary angiography
1.7
10.2
238
1513
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5.6
10.0
28
51
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.5
9.8
79
332
N19
ICPC
Speech disorder
4.8
9.8
31
65
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.5
9.6
451
3392
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.1
9.6
104
506
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
6.9
9.6
23
34
B01AB05
ATC
enoxaparin; parenteral
1.5
9.5
436
3266
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
+∞
9.4
9
*
A02BC03
ATC
lansoprazole; oral
1.5
9.3
415
3087
J01CA08
ATC
pivmecillinam; oral
1.5
9.2
435
3271
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
9.2
425
3184
I69
ICD-10 Finland
Sequelae of cerebrovascular disease
8.3
9.1
19
23
C09CA01
ATC
losartan; oral
1.5
9.1
368
2681
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
9.1
342
2450
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
9.0
64
253
R47.1
ICD-10 Finland
Dysarthria and anarthria
5.8
8.9
24
42
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
8.9
575
4586
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
8.0
8.9
19
24
M79.6
ICD-10 Finland
Pain in limb
1.4
8.8
447
3407
TAB00
NOMESCO Finland
Lumbar puncture
2.8
8.7
53
192
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.5
8.7
69
288
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
8.7
188
1170
A06AD11
ATC
lactulose; oral
1.6
8.7
242
1613
J01DA01
ATC
[U] cefalexin; systemic
1.4
8.6
828
7067
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
8.6
383
2838
N03AF02
ATC
oxcarbazepine; oral
3.0
8.6
49
168
A10BA02
ATC
metformin; oral
1.4
8.6
427
3239
I50.0
ICD-10 Finland
Congestive heart failure
1.8
8.5
163
977
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.9
8.5
33
86
A02BC02
ATC
pantoprazole; systemic
1.4
8.4
879
7596
I20.01
ICD-10 Finland
Unstable angina
2.4
8.4
68
290
Z02.7
ICD-10 Finland
Issue of medical certificate
2.3
8.4
78
354
R1260
NOMESCO Finland
Evaluation of communicative skills
3.6
8.4
36
102
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
2.8
8.4
53
196
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
+∞
8.3
8
*
G46.2
ICD-10 Finland
Posterior cerebral artery syndrome
+∞
8.3
8
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
8.3
117
632
WX872
NOMESCO Finland
Intensive care
2.2
8.3
85
403
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
8.3
375
2790
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
8.2
407
3078
WX892
NOMESCO Finland
Monitored bed care
1.9
8.2
122
671
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.4
8.2
67
287
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
5.0
8.2
25
51
R13
ICD-10 Finland
Dysphagia
2.0
8.2
100
511
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.5
8.2
36
104
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
8.2
329
2385
N30.0
ICD-10 Finland
Acute cystitis
1.7
8.1
176
1094
I50.9
ICD-10 Finland
Heart failure, unspecified
1.5
8.1
278
1946
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
33.5
8.1
10
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
8.1
230
1539
XCK00
NOMESCO Finland
Perimetry
1.9
8.0
113
610
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.1
8.0
42
139
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.7
8.0
170
1051
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
8.0
226
1511
J01EA01
ATC
trimethoprim; systemic
1.5
7.9
326
2372
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.4
7.9
373
2792
SPAT1081
SPAT
Cardiorespiratory global assessment
2.0
7.9
100
520
C10AA03
ATC
pravastatin; oral
1.8
7.8
130
745
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
7.7
260
1812
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
15.1
7.7
12
8
PA7CC
NOMESCO Finland
Very extensive angiography of arteries of neck and brain
15.1
7.7
12
8
F06.7
ICD-10 Finland
Mild cognitive disorder
3.0
7.7
42
143
N28
ICPC
Limited function/disability (N)
3.7
7.7
31
84
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
2.5
7.6
57
235
KMAK
NOMESCO Finland
NA
1.4
7.5
539
4344
A10BH01
ATC
sitagliptin; oral
1.7
7.5
146
880
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.7
7.5
159
984
SPAT1284
SPAT
Extensive health certificate
3.2
7.5
37
118
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.8
7.4
47
174
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
7.7
7.4
16
21
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
3.0
7.3
39
131
H25.1
ICD-10 Finland
Senile nuclear cataract
1.4
7.3
466
3678
U04
ICPC
Incontinence urine
2.2
7.3
71
331
G463, I639
ICD-10 Finland
NA
+∞
7.3
7
*
F0019, G301
ICD-10 Finland
NA
+∞
7.3
7
*
G46.1*I66.1
ICD-10 Finland
Anterior cerebral artery syndrome
+∞
7.3
7
*
C08CA13
ATC
lercanidipine; oral
1.6
7.2
205
1369
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
4.7
7.2
23
50
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.4
7.2
33
100
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.4
7.1
32
95
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
8.0
7.1
15
19
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
7.1
211
1425
SPAT1251
SPAT
Organisation of medication
2.2
6.9
64
293
SPAT1097
SPAT
Recording of ECG
1.5
6.9
220
1513
R4130
NOMESCO Finland
Speech therapy
3.2
6.9
34
109
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
6.8
274
1979
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
6.8
292
2137
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
3.6
6.8
28
78
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.2
6.8
63
290
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.5
6.7
204
1388
R47.0
ICD-10 Finland
Dysphasia and aphasia
4.1
6.7
24
59
SPAT1279
SPAT
Preparation of immediate hospitalisation
4.0
6.7
25
64
M48.0
ICD-10 Finland
Spinal stenosis
1.6
6.7
189
1265
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.4
6.6
30
90
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.3
6.6
536
4387
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.6
6.6
158
1011
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.5
145
907
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
6.5
170
1113
N06AX21
ATC
duloxetine; oral
1.8
6.5
108
618
A10AE05
ATC
insulin detemir; parenteral
2.0
6.5
77
391
C02AC05
ATC
moxonidine; oral
2.0
6.5
77
392
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.5
154
982
WX704
NOMESCO Finland
Intubation
1.9
6.5
95
524
N03AX16
ATC
pregabalin; oral
1.4
6.5
294
2175
G51.0
ICD-10 Finland
Bell palsy
3.0
6.5
35
120
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.7
6.5
125
755
S70.0
ICD-10 Finland
Contusion of hip
2.2
6.4
58
264
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
14.4
6.4
10
7
I69.4
ICD-10 Finland
Sequelae of stroke, not specified as haemorrhage or infarction
14.4
6.4
10
7
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
6.4
193
1310
N06AA09
ATC
amitriptyline; systemic
1.7
6.4
137
850
H02AB06
ATC
prednisolone; systemic
1.3
6.4
625
5258
A10BB12
ATC
glimepiride; oral
1.7
6.4
134
830
WW200
SPAT
NA
1.8
6.3
110
643
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
3.2
6.3
30
94
C09AA02
ATC
enalapril; systemic
1.4
6.3
332
2522
SPAT1285
SPAT
Provision of consultation response
2.0
6.3
77
397
G46.6
ICD-10 Finland
Pure sensory lacunar syndrome
+∞
6.3
6
*
G464, I639
ICD-10 Finland
NA
+∞
6.3
6
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
6.2
144
913
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.8
6.2
37
135
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
1.8
6.2
98
555
A10AA02
ATC
NA
2.3
6.2
54
243
N29
ICPC
Neurological sympt/complt other
3.3
6.2
28
85
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
2.8
6.2
36
129
Z00.0
ICD-10 Finland
General medical examination
1.5
6.1
228
1619
F05.9
ICD-10 Finland
Delirium, unspecified
2.9
6.1
35
122
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.7
6.1
117
705
N17
ICPC
Vertigo/dizziness
1.6
6.1
149
960
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
6.1
76
396
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
12.6
6.1
10
8
J01CA04
ATC
amoxicillin; systemic
1.3
6.1
976
8786
N06AB04
ATC
citalopram; systemic
1.5
6.0
248
1798
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
821
4242
2.85
94.49
2.7
2.1
183.1
231.9
u/l
0.89
772
3964
533
2277
2.97
86.17
2.0
2.0
28.6
30.1
s
6.39
520
2212
280
961
3.30
64.43
7.5
6.6
24.8
24.4
mmol/l
0.79
270
892
546
2738
2.48
60.77
5.9
4.3
1.1
1.0
kg/l
0.51
83
423
327
1400
2.66
49.53
3.1
2.5
5.0
6.9
ug/l
1.07
292
1234
374
1780
2.42
44.90
6.7
6.8
5.1
5.1
kpa
0.03
357
1682
374
1781
2.42
44.83
6.7
6.8
11.3
11.8
kpa
1.39
357
1683
322
1444
2.52
43.90
7.1
7.6
119.9
119.9
g/l
0.01
311
1388
370
1789
2.37
42.64
6.8
6.8
1.8
1.1
mmol/l
2.54
278
1372
811
5553
1.90
35.24
5.4
4.2
44.4
56.4
ng/l
0.62
646
4289
490
2874
2.00
33.47
1.8
1.8
1243.1
1193.1
nmol/l
0.62
396
2142
197
788
2.70
33.44
3.5
3.3
25.5
25.1
mmol/l
0.85
189
759
115
344
3.52
32.27
6.5
6.2
105.6
105.2
mmol/l
0.44
106
307
150
529
3.02
32.14
4.5
3.9
1.3
1.5
mmol/l
1.86
150
518
326
1680
2.17
31.31
12.5
8.2
—
—
—
0
0
397
2205
2.05
31.29
36.3
30.9
1.7
1.5
inr
0.98
34
296
548
3411
1.90
30.97
5.9
4.3
0.0
0.0
estimate
0.50
99
1139
164
640
2.73
29.09
5.3
4.6
1.7
1.6
%
0.73
153
599
1042
8086
1.77
26.85
6.5
4.8
7.1
6.9
mmol/l
2.57
989
7621
341
1887
2.01
26.69
6.0
6.6
104.6
104.2
mmol/l
0.81
335
1833
325
1792
2.01
25.60
2.0
1.8
—
—
—
0
0
276
1443
2.09
25.10
4.0
3.6
2.2
2.0
mmol/l
0.37
220
1141
241
1202
2.18
24.74
3.4
2.8
4.6
4.5
kpa
0.37
228
1158
679
4768
1.72
24.19
5.8
4.2
—
—
—
0
0
275
1457
2.06
24.07
3.9
3.5
5.9
5.8
kpa
0.26
263
1408
816
6037
1.69
23.81
5.6
4.9
34.3
34.5
g/l
0.41
756
5580
318
1801
1.95
22.97
2.0
1.8
—
—
—
0
0
906
6973
1.66
22.05
8.2
7.0
1.2
1.2
mmol/l
2.87
824
5849
835
6372
1.62
20.41
7.1
6.1
1.2
1.2
mmol/l
5.02
793
5741
1078
8775
1.65
20.15
6.1
5.0
450.8
1017.9
e6/l
0.57
21
140
813
6229
1.60
19.06
5.4
3.9
0.0
0.0
estimate
0.00
103
1199
203
1048
2.07
18.82
1.8
1.6
—
—
—
0
0
818
6313
1.58
18.33
5.5
4.0
0.0
0.0
estimate
0.50
101
1169
769
5868
1.58
17.98
2.2
2.1
92.0
93.5
pmol/l
0.39
443
3042
52
138
3.86
17.41
1.3
1.2
2.0
4.1
u/ml
—
9
42
433
2909
1.66
16.96
4.8
4.2
273.3
379.0
ng/l
0.55
363
2523
25
37
6.84
16.16
1.0
1.0
97.9
97.1
%
0.04
25
27
798
6242
1.53
16.06
6.7
5.3
0.0
0.0
estimate
0.00
102
1200
64
207
3.18
15.89
1.5
1.3
8.4
58.1
e6/l
1.05
52
165
64
207
3.18
15.89
1.6
1.4
2192.0
1137.0
e6/l
0.34
53
172
69
242
2.93
14.92
1.3
1.3
552.8
565.8
mg/l
0.09
63
230
230
1343
1.83
14.68
5.9
6.5
1.5
1.4
mmol/l
0.35
223
1289
46
127
3.70
14.59
1.2
1.1
—
—
—
0
0
380
2555
1.63
14.54
2.2
1.9
—
—
—
0
0
164
862
2.00
14.38
1.7
1.5
—
—
—
0
0
47
136
3.53
13.93
1.3
1.2
6.8
7.0
u/ml
0.01
17
63
62
215
2.96
13.69
1.3
1.3
4.2
3.9
mmol/l
0.72
56
199
173
948
1.92
13.43
8.0
8.7
93.7
94.0
%
0.33
173
941
774
6171
1.48
13.29
5.0
4.3
—
—
—
0
0
43
129
3.40
12.09
1.2
1.1
119.5
113.8
%
0.59
43
115
1053
9021
1.46
11.78
3.9
3.8
15.3
15.1
pmol/l
1.66
970
8045
1362
12307
1.59
11.66
23.7
17.3
27.4
27.0
mg/l
0.15
1176
10108
651
5167
1.43
10.72
3.9
3.5
—
—
—
0
0
1155
10152
1.45
10.67
7.5
7.8
82.5
81.2
u/l
0.25
1091
9492
292
1981
1.57
10.43
5.9
5.5
1.0
1.0
mmol/l
0.03
269
1841
375
2688
1.51
10.43
3.4
3.1
2.5
2.5
mmol/l
0.16
329
2332
546
4215
1.44
10.40
2.7
2.5
53.0
57.4
u/l
2.99
507
3872
497
3772
1.45
10.36
2.6
2.2
3.2
3.1
mg/l
0.48
437
3207
635
5071
1.41
9.88
2.3
2.2
77.0
79.3
nmol/l
1.36
577
4396
92
450
2.11
9.82
1.3
1.3
—
—
—
0
0
413
3054
1.47
9.77
1.9
1.7
433.9
22733197.0
pmol/l
2.15
371
2481
76
345
2.26
9.77
2.3
2.1
96.2
87.3
%
4.02
76
326
232
1513
1.62
9.75
3.4
3.1
232.3
271.0
ng/l
0.68
213
1383
34
104
3.32
9.33
1.6
1.3
—
—
—
0
0
617
4940
1.40
9.31
3.8
3.2
1935.2
1830.6
ng/l
0.21
559
4321
1407
12978
1.54
9.20
29.0
20.6
139.7
139.5
mmol/l
1.84
1379
12639
176
1085
1.70
9.19
2.4
3.2
61.7
59.3
ml/min/173m2
0.37
76
479
1408
13000
1.54
9.05
28.9
20.8
4.0
4.0
mmol/l
0.76
1374
12650
119
660
1.86
8.90
2.0
1.9
1.4
1.9
ug/l
0.21
106
582
577
4598
1.39
8.85
3.1
3.5
2.3
2.3
mmol/l
0.96
512
3927
839
7123
1.36
8.56
5.6
6.3
12.3
12.4
umol/l
0.07
794
6773
1227
11082
1.41
8.40
5.1
4.7
2.0
2.1
mu/l
0.92
1144
9905
453
3525
1.39
7.83
1.6
1.6
18.9
20.1
nmol/l
0.90
412
2944
100
1699
0.56
7.29
5.7
4.8
33.8
33.2
%
0.24
75
1108
29
95
3.09
7.18
1.1
1.1
—
—
—
0
0
564
4616
1.34
6.90
3.8
4.0
10.4
9.4
mg/mmol
0.25
402
2976
1271
11690
1.37
6.73
7.6
6.5
42.9
40.9
mmol/mol
9.24
1210
10662
204
1408
1.51
6.62
6.8
6.7
11.6
11.5
mmol/l
0.05
191
1333
16
37
4.36
6.49
1.2
1.1
—
—
—
0
0
1051
9423
1.31
6.49
4.6
4.2
15.1
14.6
mm/h
0.44
997
8637
540
4432
1.32
6.37
3.3
3.2
7.1
7.2
mmol/l
0.13
481
3662
20
58
3.48
6.01
1.3
1.0
—
—
—
0
0
15
36
4.20
5.82
1.2
1.4
1.2
1.2
mmol/l
0.14
15
36
63
332
1.93
5.60
1.2
1.2
—
—
—
0
0
17
47
3.64
5.48
1.2
1.2
—
—
—
0
0
166
1142
1.50
5.48
4.5
3.7
109.0
98.4
ng/l
0.60
152
983
63
335
1.92
5.46
1.2
1.2
—
—
—
0
0
35
148
2.39
5.41
2.3
2.2
—
—
—
0
0
1417
13390
1.39
5.37
34.0
25.4
239.5
240.0
e9/l
0.08
1389
12991
24
84
2.88
5.36
1.1
1.1
—
—
—
0
0
1417
13394
1.39
5.33
34.0
25.4
4.4
4.4
e12/l
1.61
1380
12948
25
615
0.40
5.32
2.0
1.8
—
—
—
0
0
1417
13396
1.39
5.30
34.0
25.5
7.2
6.9
e9/l
4.04
1380
12943
1417
13396
1.39
5.30
34.1
25.6
131.3
133.1
g/l
4.09
1392
13148
26
96
2.74
5.28
1.3
1.1
92.1
96.8
%
0.44
26
90
70
391
1.82
5.22
1.1
1.2
0.3
1.1
u/ml
0.67
13
29
306
2376
1.35
5.14
2.9
2.6
11.1
12.3
umol/l
2.11
289
2197
345
2733
1.33
5.06
2.1
1.6
1.3
1.4
mg/l
0.32
270
2127
835
7403
1.26
5.01
8.2
8.9
4.6
4.3
e9/l
2.42
761
6424
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
98
611
1.64
4.97
3.7
2.4
0.3
0.4
u/ml
0.18
61
359
611
5232
1.27
4.91
3.3
2.9
136.2
154.2
ug/l
1.29
566
4755
31
131
2.39
4.83
1.5
1.3
6194.3
150875.6
e6/l
1.15
21
88
1079
9878
1.26
4.81
26.6
21.1
14.1
13.9
%
4.74
1055
9639
1377
13018
1.33
4.68
12.5
11.3
27.4
25.2
u/l
0.58
1331
12470
23
86
2.70
4.59
1.0
1.0
—
—
—
0
0
7
5
14.05
4.57
1.0
1.2
—
—
—
0
0
25
98
2.57
4.56
1.6
1.4
—
—
—
0
0
25
98
2.57
4.56
1.6
1.4
—
—
—
0
0
13
35
3.74
4.37
1.1
1.4
1.2
1.2
mmol/l
0.41
13
35
382
3126
1.29
4.36
2.6
2.7
4.1
4.7
e6/l
0.67
346
2764
54
296
1.85
4.33
2.1
1.7
—
—
—
0
0
62
357
1.77
4.24
1.3
1.3
—
—
—
0
0
62
357
1.77
4.24
1.3
1.3
—
—
—
0
0
292
2316
1.32
4.20
3.2
3.1
0.8
0.8
mmol/l
0.05
266
2159
1226
11508
1.25
3.82
4.8
4.2
1.3
1.3
mmol/l
1.60
1149
10274
50
281
1.80
3.74
1.6
2.7
27.3
34.4
umol/l
2.53
42
229
243
1915
1.31
3.65
2.1
2.5
1.8
1.8
%
0.05
216
1699
459
3912
1.24
3.64
3.1
3.1
31.9
35.2
u/l
0.77
433
3711
58
345
1.71
3.59
1.3
1.6
0.9
0.3
iu/ml
0.43
17
72
33
164
2.03
3.56
1.8
1.5
—
—
—
0
0
15
52
2.90
3.46
1.6
1.2
—
—
—
0
0
11
32
3.45
3.33
1.1
1.1
—
—
—
0
0
52
307
1.72
3.33
1.7
1.6
—
—
—
0
0
1141
10689
1.21
3.33
24.9
18.7
38.5
38.7
%
0.23
614
6809
26
123
2.13
3.20
1.4
1.2
6.7
7.6
mmol/l
0.79
17
89
14
50
2.82
3.09
2.1
1.2
—
—
—
0
0
1297
12344
1.23
3.05
6.4
5.3
2.2
2.6
mmol/l
42.51
1237
11144
10
29
3.46
3.05
1.1
1.0
1474.7
1471.8
miu/ml
—
10
29
300
2488
1.25
3.01
3.2
2.9
2.0
1.3
e6/l
1.08
205
1471
9
21
4.30
2.99
1.3
1.2
—
—
—
0
0
16
63
2.55
2.96
1.1
1.0
261.2
279.1
ng/l
—
9
37
16
63
2.55
2.96
1.1
1.0
37.6
40.4
ng/l
—
9
36
16
63
2.55
2.96
1.1
1.0
816.1
730.8
ng/l
—
9
36
69
455
1.54
2.89
1.2
1.3
—
—
—
0
0
51
313
1.65
2.87
3.0
2.4
216.4
204.3
%
0.46
51
299
524
4622
1.20
2.84
4.5
4.8
24.2
21.9
%
2.19
261
2421
24
116
2.08
2.83
1.3
1.3
25.8
28.9
%
0.15
15
72
268
2210
1.25
2.82
3.0
2.6
2.3
2.3
g/l
0.25
257
2037
253
2086
1.25
2.67
3.2
2.6
19.7
22.0
%
2.01
185
1780
10
32
3.14
2.65
1.2
1.1
—
—
—
0
0
30
162
1.87
2.63
1.2
1.3
0.6
0.7
nmol/l
0.11
30
151
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
61
2.47
2.62
1.2
1.1
—
—
—
0
0
53
340
1.58
2.53
1.7
1.6
21019.3
15991.2
e6/l
0.23
40
245
13
50
2.61
2.53
1.2
1.1
—
—
—
0
0
47
294
1.62
2.49
1.5
1.4
—
—
—
0
0
11
39
2.83
2.47
1.0
1.1
—
—
—
0
0
657
5964
1.17
2.46
2.7
2.4
—
—
—
0
0
81
576
1.43
2.39
3.3
2.6
—
—
—
0
0
40
243
1.66
2.39
1.3
1.5
—
—
—
0
0
16
72
2.23
2.28
3.4
1.8
17.0
17.6
%
—
6
31
1107
11624
0.86
2.27
19.4
16.6
71.6
72.9
ml/min/173m2
1.04
901
9712
20
99
2.03
2.26
1.1
1.3
—
—
—
0
0
1244
11901
1.18
2.25
5.3
4.7
1.3
1.4
mmol/l
11.85
1175
10703
27
149
1.83
2.25
2.3
1.7
—
—
—
0
0
284
3314
0.83
2.23
2.7
3.3
0.9
0.8
ug/l
0.29
198
2351
51
336
1.53
2.21
1.9
1.7
—
—
—
0
0
11
42
2.63
2.18
1.0
1.0
—
—
—
0
0
9
30
3.01
2.15
1.1
1.1
—
—
—
0
0
9
30
3.01
2.15
1.2
1.1
—
—
—
0
0
9
30
3.01
2.15
1.1
1.1
—
—
—
0
0
24
130
1.86
2.13
2.4
1.6
—
—
—
0
0
24
130
1.86
2.13
2.4
1.6
—
—
—
0
0
24
130
1.86
2.13
2.4
1.6
—
—
—
0
0
95
713
1.35
2.07
4.7
3.7
23.5
24.1
mmol/l
0.96
77
635
1262
12116
1.17
2.06
5.6
5.1
6.3
6.1
mmol/l
4.54
1171
10809
6
15
4.01
2.04
1.0
1.1
—
—
—
0
0
807
7510
1.14
2.03
3.2
3.2
55.9
55.6
u/l
0.03
746
6879
1252
12017
1.17
2.03
5.6
4.7
4.0
4.4
mmol/l
38.04
1191
10921
55
377
1.47
2.00
2.2
2.4
191.3
86.0
ug/min
0.60
24
222
35
217
1.63
1.98
1.3
1.4
—
—
—
0
0
5
11
4.56
1.94
1.0
1.0
—
—
—
0
0
417
3713
1.16
1.94
3.1
3.0
3724.0
7791.8
umol/l
1.21
356
3139
6
16
3.76
1.93
1.2
2.2
—
—
—
0
0
6
16
3.76
1.93
1.0
1.0
—
—
—
0
0
104
802
1.32
1.91
1.4
1.8
1.6
1.5
g/l
0.20
95
694
27
159
1.71
1.86
1.3
1.5
—
—
—
0
0
28
167
1.69
1.84
1.4
1.4
52.6
63.8
%
0.61
18
108
103
798
1.31
1.84
3.2
2.8
0.3
0.3
e6/l
0.05
103
779
6
17
3.54
1.84
17.0
14.9
5.7
5.9
mmol/l
—
6
17
5
12
4.18
1.82
1.0
1.4
8.4
14.1
u/l
—
5
12
5
12
4.18
1.82
1.0
1.3
—
—
—
0
0
27
160
1.70
1.82
3.0
2.9
—
—
—
0
0
55
386
1.44
1.80
1.4
1.3
—
—
—
0
0
50
345
1.46
1.79
3.7
3.3
8.1
7.6
mmol/l
0.58
50
337
8
29
2.77
1.79
1.0
1.2
—
—
—
0
0
221
1877
1.20
1.79
1.2
1.2
30.4
38.8
iu/ml
0.43
65
586
167
1380
1.23
1.77
2.8
2.7
66.1
66.1
g/l
0.00
156
1263
15
75
2.01
1.69
4.7
1.8
492.2
673.3
e6/l
—
8
33
52
367
1.43
1.67
3.6
3.2
1.6
1.7
mmol/l
0.07
52
358
12
55
2.19
1.67
1.3
1.1
—
—
—
0
0
15
76
1.98
1.64
1.9
2.1
—
—
—
0
0
14
70
2.01
1.59
3.8
1.9
—
—
—
0
0
50
356
1.42
1.55
1.9
1.6
—
—
—
0
0
8
33
2.43
1.54
5.7
1.7
—
—
—
0
0
15
271
0.55
1.53
3.9
3.4
59.9
59.6
%
0.04
15
271
20
115
1.75
1.52
1.3
1.5
32.3
25.8
u/ml
—
8
21
79
608
1.31
1.52
2.3
3.1
4.1
4.4
pmol/l
1.77
69
525
370
3323
1.15
1.52
3.1
2.5
—
—
—
0
0
15
79
1.91
1.49
1.1
1.2
—
—
—
0
0
15
79
1.91
1.49
1.1
1.2
—
—
—
0
0
443
4033
1.13
1.48
3.5
3.4
0.5
0.5
e6/l
0.03
375
3129
96
1198
0.79
1.47
4.0
3.9
1.2
1.2
mmol/l
0.61
91
1040
36
245
1.48
1.43
1.1
1.1
—
—
—
0
0
36
245
1.48
1.43
1.3
1.4
—
—
—
0
0
23
141
1.64
1.42
2.5
1.7
—
—
—
0
0
50
363
1.39
1.41
1.4
1.8
—
—
—
0
0
47
338
1.40
1.41
1.6
2.3
129.5
125.1
g/l
0.44
36
246
59
441
1.35
1.40
3.5
3.2
0.8
0.8
nmol/l
0.71
48
346
15
261
0.57
1.37
3.1
3.1
4.6
4.6
e9/l
0.05
15
261
5
18
2.78
1.28
1.4
1.1
—
—
—
0
0
67
522
1.30
1.23
1.4
2.0
34.4
38.6
u/l
1.21
55
452
11
56
1.97
1.22
1.1
1.2
—
—
—
0
0
255
2270
1.15
1.20
1.3
1.2
2.8
1.8
u/ml
0.39
84
586
47
618
0.75
1.12
3.0
2.0
—
—
—
0
0
11
196
0.56
1.12
1.5
2.2
3.2
209.3
u/ml
0.51
11
189
7
31
2.26
1.10
3.9
1.7
—
—
—
0
0
7
31
2.26
1.10
1.0
1.1
—
—
—
0
0
128
1089
1.19
1.09
2.2
2.2
344.6
370.1
nmol/l
0.86
108
989
205
1812
1.15
1.08
1.2
1.2
4.9
13.3
u/ml
1.66
89
646
28
194
1.45
1.07
1.3
1.5
—
—
—
0
0
23
337
0.68
1.06
3.2
2.6
16.3
15.7
%
0.27
15
176
41
305
1.35
1.06
1.6
1.6
—
—
—
0
0
43
563
0.76
1.02
2.1
1.8
—
—
—
0
0
30
213
1.42
1.02
1.2
1.6
—
—
—
0
0
25
172
1.46
1.00
1.4
1.4
—
—
—
0
0
205
1830
1.14
0.96
3.9
4.0
225.5
251.7
u/l
3.78
196
1727
10
172
0.58
0.93
5.2
4.1
58.0
58.8
%
—
10
110
133
1526
0.86
0.92
2.3
2.7
8.0
10.2
umol/l
0.99
116
1345
23
324
0.71
0.89
1.3
1.3
—
—
—
0
0
14
218
0.64
0.89
1.1
1.1
—
—
—
0
0
47
587
0.79
0.81
4.8
4.0
23.6
24.9
mmol/l
2.25
42
546
135
1188
1.15
0.80
2.0
2.1
160.4
155.5
ug/g
0.04
114
912
13
82
1.59
0.78
1.5
1.9
—
—
—
0
0
0
28
0.00
0.76
0.0
2.0
—
38.5
—
0
11
146
1302
1.13
0.73
2.1
2.1
0.2
0.2
g/l
0.60
137
1212
80
933
0.85
0.72
3.9
3.7
1.0
1.9
mmol/l
1.10
57
699
19
134
1.42
0.71
1.7
1.9
—
—
—
0
0
7
41
1.71
0.70
1.1
1.3
—
—
—
0
0
7
41
1.71
0.70
1.0
1.2
—
—
—
0
0
33
257
1.29
0.69
2.1
1.7
—
—
—
0
0
11
69
1.60
0.68
1.5
1.6
18.7
16.8
nmol/l
0.25
11
62
23
307
0.75
0.68
1.3
1.2
6.0
6.5
u/ml
—
6
51
86
990
0.86
0.67
3.7
3.7
5.0
5.1
kpa
1.06
76
920
20
271
0.73
0.66
3.9
4.1
1.1
1.4
%
0.25
20
208
96
842
1.15
0.63
9.4
8.6
24.2
24.4
mmol/l
0.20
83
779
139
1542
0.89
0.63
3.9
3.7
—
—
—
0
0
27
208
1.30
0.62
1.3
1.1
—
—
—
0
0
8
49
1.64
0.62
1.0
1.2
—
—
—
0
0
46
382
1.21
0.58
1.6
1.5
292.9
271.6
ug/g
0.26
32
235
6
35
1.72
0.57
1.3
1.1
—
—
—
0
0
39
473
0.82
0.57
1.6
1.7
—
—
—
0
0
23
176
1.31
0.56
1.3
1.3
117.2
116.7
u/ml
—
5
35
42
505
0.83
0.56
2.3
2.5
38.2
37.0
g/l
0.86
37
435
19
142
1.34
0.54
1.0
1.1
—
18.2
—
0
6
10
66
1.52
0.52
1.1
1.2
141.2
397.9
u/l
—
10
60
9
64
1.41
0.51
1.0
1.1
—
—
—
0
0
25
197
1.27
0.51
1.4
1.5
—
—
—
0
0
590
5696
1.06
0.48
4.6
5.6
3.0
4.5
ug/l
0.97
542
5056
11
76
1.45
0.48
1.5
1.4
13.8
16.0
umol/l
0.44
11
71
5
85
0.59
0.45
1.2
1.1
—
—
—
0
0
36
427
0.84
0.44
1.6
1.6
—
—
—
0
0
90
997
0.90
0.44
1.8
1.6
—
—
—
0
0
42
358
1.18
0.44
3.7
2.3
3.9
3.6
g/l
0.67
42
339
20
252
0.79
0.43
3.0
2.0
1.4
1.7
mmol/l
1.25
20
245
9
128
0.70
0.43
1.8
1.3
—
—
—
0
0
51
444
1.15
0.42
1.1
1.1
—
—
—
0
0
30
249
1.21
0.41
6.0
5.4
423.0
1110.8
iu/ml
—
7
36
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
31
368
0.84
0.40
1.8
1.6
—
—
—
0
0
7
101
0.69
0.39
1.6
1.5
—
—
—
0
0
5
35
1.43
0.39
1.0
2.9
—
—
—
0
0
18
226
0.79
0.39
1.3
1.3
—
—
—
0
0
15
190
0.79
0.35
4.3
3.6
—
—
—
0
0
37
424
0.87
0.33
2.5
3.3
24.5
25.0
mmol/l
0.17
31
366
17
137
1.24
0.32
1.2
1.1
—
—
—
0
0
7
53
1.32
0.31
1.6
2.2
1964.9
1545.5
u/ml
—
7
53
7
55
1.27
0.30
2.9
2.6
—
—
—
0
0
7
55
1.27
0.30
2.9
2.6
—
—
—
0
0
12
94
1.28
0.28
3.8
2.3
75.8
63.8
ug/min
—
6
17
20
168
1.19
0.27
1.2
1.1
21.4
27.4
iu/ml
—
5
30
14
171
0.82
0.26
1.4
1.7
—
—
—
0
0
5
74
0.67
0.26
1.8
1.1
—
—
—
0
0
5
74
0.67
0.26
1.8
1.1
—
—
—
0
0
5
75
0.67
0.26
1.8
1.1
—
—
—
0
0
5
75
0.67
0.26
1.8
1.1
—
—
—
0
0
5
75
0.67
0.26
1.8
1.1
—
—
—
0
0
9
75
1.20
0.25
1.6
1.4
—
—
—
0
0
9
75
1.20
0.25
1.6
1.4
—
—
—
0
0
6
84
0.71
0.24
1.7
1.6
—
—
—
0
0
6
84
0.71
0.24
1.7
1.6
—
—
—
0
0
20
171
1.17
0.23
1.8
1.8
—
—
—
0
0
47
428
1.10
0.23
1.4
1.6
—
—
—
0
0
50
546
0.91
0.23
2.6
2.7
1.7
1.5
g/l
0.07
45
470
111
1049
1.06
0.23
1.9
1.7
1.6
1.6
%
0.00
101
875
7
93
0.75
0.22
1.4
1.2
—
—
—
0
0
5
40
1.25
0.22
2.4
1.5
—
—
—
0
0
28
248
1.13
0.21
1.5
1.5
898.9
1702.7
e6/l
1.59
21
181
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(46236287) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Pleural fluid by Immunoassay
0
12
0.00
0.21
0.0
1.3
—
5998.6
—
0
7
0
12
0.00
0.21
0.0
1.1
—
0.2
—
0
5
11
89
1.24
0.21
1.8
3.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
25.6
—
0
13
0
14
0.00
0.20
0.0
1.1
—
96.1
—
0
14
15
176
0.85
0.20
1.1
1.1
380.4
298.6
u/ml
—
8
96
57
613
0.93
0.19
3.0
2.6
9.9
10.6
g/l
0.62
46
522
16
186
0.86
0.19
1.1
1.1
—
—
—
0
0
6
53
1.13
0.18
6.3
1.9
—
—
—
0
0
6
53
1.13
0.18
6.3
1.9
—
—
—
0
0
90
949
0.95
0.18
2.6
2.2
11.5
12.4
nmol/l
0.47
76
818
18
206
0.87
0.18
1.6
1.3
—
—
—
0
0
7
59
1.19
0.18
2.7
1.6
—
—
—
0
0
36
329
1.10
0.17
2.9
3.2
317.3
1306.1
u/ml
0.65
31
307
5
66
0.76
0.17
3.0
3.4
205.6
216.3
u/l
—
5
66
115
1104
1.04
0.15
1.3
1.4
—
—
—
0
0
12
140
0.86
0.15
1.2
1.2
40.7
53.6
u/l
—
6
97
57
605
0.94
0.15
2.8
2.6
3.0
3.2
g/l
0.65
39
481
30
326
0.92
0.14
3.4
3.9
24.1
30.6
mg/l
0.57
20
207
15
170
0.88
0.13
2.0
1.4
—
—
—
0
0
15
170
0.88
0.13
2.0
1.4
—
—
—
0
0
327
3331
0.98
0.13
1.7
1.6
1.3
1.3
mmol/l
0.21
297
2745
15
169
0.89
0.12
2.0
1.4
—
—
—
0
0
15
169
0.89
0.12
2.0
1.4
—
—
—
0
0
15
169
0.89
0.12
2.0
1.4
—
—
—
0
0
25
229
1.09
0.12
1.5
1.5
160741.3
88045.6
e6/l
0.23
14
138
120
1239
0.97
0.12
2.3
2.3
30.7
35.8
u/l
1.05
107
1055
22
201
1.10
0.11
1.3
1.4
6.1
6.7
mmol/l
0.43
22
190
62
592
1.05
0.11
1.1
1.2
56.0
128.8
iu/ml
1.51
21
221
5
44
1.14
0.10
1.0
2.2
12.5
1.4
nmol/l
—
5
34
54
564
0.96
0.09
4.1
3.4
1.3
1.8
ratio
—
6
47
5
48
1.04
0.09
1.0
1.6
—
—
—
0
0
56
584
0.96
0.09
2.8
3.1
7504.1
7378.8
u/ml
0.01
50
498
6
55
1.09
0.09
6.3
1.9
—
—
—
0
0
22
204
1.08
0.08
1.2
1.3
9.7
9.9
u/l
0.04
17
157
129
1321
0.97
0.08
1.7
1.3
—
—
—
0
0
59
613
0.96
0.08
1.2
1.2
121.3
223.7
u/ml
2.14
52
551
5
65
0.77
0.08
2.4
1.5
0.9
1.0
g/l
—
5
65
11
123
0.89
0.08
2.1
2.3
612.4
668.1
ml
—
5
76
7
67
1.04
0.08
1.0
1.1
—
—
—
0
0
8
75
1.07
0.07
2.8
2.3
—
—
—
0
0
13
118
1.10
0.07
1.3
1.2
—
—
—
0
0
25
265
0.94
0.07
1.4
1.3
—
—
—
0
0
8
95
0.84
0.06
1.0
1.3
—
—
—
0
0
8
95
0.84
0.06
1.0
1.3
—
—
—
0
0
21
197
1.07
0.06
1.8
1.9
182.6
213.8
pmol/l
0.84
21
182
35
364
0.96
0.05
2.1
3.1
8.1
7.8
kpa
0.47
30
336
64
652
0.98
0.03
2.8
2.5
7.6
7.5
g/l
0.13
41
486
166
1646
1.01
0.02
3.3
4.1
9.0
24.9
ug/l
1.36
145
1382
64
651
0.98
0.02
2.8
2.5
—
—
—
0
0
64
650
0.98
0.02
2.8
2.5
3.7
3.8
g/l
0.47
38
469
13
123
1.06
0.01
1.6
1.7
—
—
—
0
0
233
2340
1.00
0.01
3.6
3.1
2.6
1.9
e6/l
0.88
141
1331
13
124
1.05
0.00
1.4
1.6
—
—
—
0
0
17
171
0.99
0.00
1.9
1.4
—
—
—
0
0
43
434
0.99
0.00
1.9
1.7
—
—
—
0
0
15
147
1.02
0.00
1.1
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
21.6
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
39.0
—
0
7
6
60
1.00
0.00
1.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
7.7
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
0.00
5.6
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.0
5.5
—
34.0
—
0
12
0
6
0.00
0.00
0.0
1.5
—
3.0
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
7
75
0.93
0.00
5.6
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
18.8
—
0
6
0
5
0.00
0.00
0.0
10.0
—
—
—
0
0
7
75
0.93
0.00
5.6
1.8
—
—
—
0
0
7
75
0.93
0.00
5.6
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_VASCSYND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VASCSYND | 1.763 [1.59, 1.95] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.426 |
During the follow-up period (1.1.1998 — 31.12.2019), 3004 out of 6262 females with I9_VASCSYND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VASCSYND | 1.723 [1.56, 1.91] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.061 |
During the follow-up period (1.1.1998 — 31.12.2019), 3452 out of 7567 males with I9_VASCSYND died.
Mortality risk
Mortality risk for people of age
years, who have I9_VASCSYND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.306% |
| 5 | 1.094% | 2.122% |
| 10 | 2.811% | 5.601% |
| 15 | 5.449% | 10.96% |
| 20 | 9.249% | 18.455% |
Relationships between endpoints
↥Index endpoint: I9_VASCSYND – Vascular syndromes of brain in cerebrovascular disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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