Molar incisor enamel hypoplasia

K11_MIH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

3 out of 7 registries used, show all original rules.

1166

4. Check minimum number of events

None

1166

5. Include endpoints

1166

6. Filter based on genotype QC (FinnGen only)

1166

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF10

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26829 14582 12214
Only index persons 19103 10748 8355
Unadjusted period prevalence (%)
Whole population 0.38 0.42 0.34
Only index persons 0.36 0.40 0.32
Median age at first event (years)
Whole population 10.94 11.50 10.22
Only index persons 13.36 13.99 12.56

-FinnGen-

Key figures

All Female Male
Number of individuals 1166 793 373
Unadjusted period prevalence (%) 0.24 0.27 0.16
Median age at first event (years) 18.61 21.25 13.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
910
Matched controls
8916
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
+∞
323.0
837
*
K00.41
ICD-10 Finland
Prenatal enamel hypoplasia
+∞
136.0
128
*
127
Kela drug reimbursment
Transplant complication
26.9
86.9
122
51
K02.0
ICD-10 Finland
Caries limited to enamel
4.1
83.2
470
1844
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
17.2
80.9
132
87
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
30.2
71.6
97
35
Z94.0
ICD-10 Finland
Kidney transplant status
34.1
71.5
94
30
H02AB09
ATC
hydrocortisone; systemic
9.7
70.5
152
181
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.5
60.2
123
131
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.3
58.5
128
154
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.4
56.7
163
296
A11CC03
ATC
alfacalcidol; systemic
17.8
55.8
89
54
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
34.7
52.9
69
21
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
19.0
51.5
80
45
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
5.1
50.4
176
401
K03.66
ICD-10 Finland
Tooth plaque
3.8
48.0
243
787
137
Kela drug reimbursment
Uraemia requiring dialysis
34.2
47.5
62
19
K03.64
ICD-10 Finland
Dental calculus supragingival
2.8
47.2
466
2417
XF602
NOMESCO Finland
Bloodpressure monitoring
18.4
46.6
73
42
L04AX01
ATC
azathioprine; systemic
7.8
46.5
113
160
L04AD01
ATC
ciclosporin; systemic
13.2
46.2
83
67
ZX120
NOMESCO Finland
Intravenous
5.1
45.1
155
344
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
19.7
45.1
69
37
L04AA06
ATC
mycophenolic acid; systemic
14.3
45.0
78
58
H02AB04
ATC
methylprednisolone; systemic
5.6
44.7
140
279
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
27.7
44.3
61
23
B03XA01
ATC
erythropoietin; parenteral
38.9
44.2
56
15
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
10.3
43.2
88
92
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
43.2
320
1360
EBA15
NOMESCO Finland
Extraction of large number of teeth
9.1
42.1
92
109
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
44.0
41.3
51
12
K06.18
ICD-10 Finland
Another gingival hyperplasia
25.2
41.1
58
24
B05DA
ATC
Isotonic solutions
46.0
40.0
49
11
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
210.0
39.8
41
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.9
39.8
104
163
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
52.6
38.5
46
9
5AB14
NOMESCO Finland
NA
57.9
38.3
45
8
602
Kela drug reimbursment
Children's severe malnutrition
7.1
37.8
97
148
A12AA04
ATC
calcium carbonate; oral
18.3
37.1
58
33
KAC00
NOMESCO Finland
Nephrectomy
36.4
35.9
46
13
K03.00
ICD-10 Finland
Approximal wear
5.9
35.2
104
191
Z99.2
ICD-10 Finland
Dependence on renal dialysis
60.0
35.1
41
7
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
35.6
34.9
45
13
Z49.2
ICD-10 Finland
Other dialysis
34.8
34.0
44
13
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
33.6
340
1691
ZX199
NOMESCO Finland
Other rote
19.9
33.0
50
26
Z94.4
ICD-10 Finland
Liver transplant status
42.0
33.0
41
10
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
10.8
31.2
61
59
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
31.1
163
525
205
Kela drug reimbursment
Chronic hypertension
6.1
30.6
87
152
N18.8
ICD-10 Finland
Other chronic renal failure
16.8
30.6
49
30
L04AA01
ATC
[U] ciclosporin; systemic
18.2
29.6
46
26
FM2CE
NOMESCO Finland
NA
4.1
28.8
120
317
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
20.0
28.6
43
22
TK820
NOMESCO Finland
Peritoneal dialysis
44.5
28.6
35
8
WX882
NOMESCO Finland
High dependency care
3.5
28.0
141
439
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
27.8
229
994
K00.50
ICD-10 Finland
Dentinal dysplasia
22.7
27.7
40
18
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
27.4
127
368
C08CA01
ATC
amlodipine; oral
4.3
27.3
107
267
V03AG01
ATC
sodium cellulose phosphate; systemic
15.4
27.2
45
30
TK800
NOMESCO Finland
Hemodialysis
14.3
27.0
46
33
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.9
27.0
183
704
RD210
NOMESCO Finland
NA
4.0
26.8
116
317
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
26.6
226
996
SCE00
NOMESCO Finland
Fissure closure of tooth
2.6
26.6
230
1023
B05DB
ATC
Hypertonic solutions
34.5
26.4
34
10
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.4
26.2
99
238
BE00A
NOMESCO Finland
NA
52.3
26.1
31
6
SFA10
NOMESCO Finland
Fillning on one surface of tooth
2.1
25.6
590
4139
Z49.1
ICD-10 Finland
Extracorporeal dialysis
19.4
25.1
38
20
C08CA02
ATC
felodipine; oral
10.7
24.2
47
45
A41.9
ICD-10 Finland
Sepsis, unspecified
6.0
24.0
68
118
R4110
NOMESCO Finland
Physiotherapy
2.3
24.0
266
1341
Z01.2
ICD-10 Finland
Dental examination
2.1
24.0
580
4094
WX110
NOMESCO Finland
Local anesthesy
2.2
23.3
700
5380
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
13.1
23.3
41
32
SAA02
NOMESCO Finland
Basic examination of mouth
2.7
23.2
815
6763
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
23.0
187
794
SDA02
NOMESCO Finland
Parodonthologic therapy
2.1
22.9
362
2134
4AA09
NOMESCO Finland
NA
36.6
22.9
29
8
XW000
NOMESCO Finland
Bone marrow biopsy
6.6
22.7
60
95
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
8.5
22.3
49
59
WW500
NOMESCO Finland
Blood transfusion
5.2
22.2
71
143
XX4AW
NOMESCO Finland
NA
6.0
22.2
63
110
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
2.2
22.1
288
1555
F59
ICD-10 Finland
Unspecified behavioural syndromes associated with physiological disturbances and physical factors
9.4
21.7
45
49
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
3.6
21.3
100
292
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
21.0
202
936
SAA03
NOMESCO Finland
Extended examination of mouth
2.0
21.0
594
4341
ZX121
NOMESCO Finland
Central venous catheter
9.8
20.7
42
44
Z94.1
ICD-10 Finland
Heart transplant status
25.7
20.3
28
11
C03CA01
ATC
furosemide; systemic
4.0
20.3
84
220
ZXA00
NOMESCO Finland
Right side
2.6
20.2
168
718
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
4.2
20.1
80
202
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
2.7
20.0
147
586
BC00A
NOMESCO Finland
NA
27.2
19.9
27
10
RS220
NOMESCO Finland
NA
5.7
19.6
57
103
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.9
19.3
589
4353
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
19.2
288
1632
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.2
18.0
70
173
K02.1
ICD-10 Finland
Caries of dentine
1.9
18.0
605
4570
C03DA01
ATC
spironolactone; oral
4.8
17.7
60
129
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
2.1
17.6
254
1407
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
17.3
154
681
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
17.3
88
274
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.4
17.2
63
147
EB1WA
NOMESCO Finland
NA
18.7
17.2
26
14
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
17.1
132
540
R50.9
ICD-10 Finland
Fever, unspecified
2.1
16.8
223
1189
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.8
16.8
501
3592
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
2.2
16.5
185
916
V03AE01
ATC
polystyrene sulfonate; oral
23.1
16.3
23
10
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.5
16.3
58
132
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
6.7
15.7
40
61
201
Kela drug reimbursment
Chronic cardiac insufficiency
6.6
15.5
40
62
ZXA10
NOMESCO Finland
Bilateral
2.2
15.4
180
906
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
16.1
15.1
24
15
6BA02
NOMESCO Finland
NA
10.4
15.1
29
28
ZXA05
NOMESCO Finland
Left side
2.4
15.0
140
632
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
15.0
105
403
3A013
NOMESCO Finland
NA
44.9
15.0
18
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
14.8
234
1331
K07.24
ICD-10 Finland
Open bite
3.8
14.7
63
171
RS221
NOMESCO Finland
NA
4.3
14.7
55
132
A05AA02
ATC
ursodeoxycholic acid; oral
5.5
14.5
43
80
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.2
14.4
45
89
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.9
14.4
93
342
TK823
NOMESCO Finland
Peritoneal permeability analysis
149.3
14.4
15
*
1AB02
NOMESCO Finland
NA
13.4
14.1
24
18
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
14.4
13.9
23
16
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.5
13.9
65
190
TFJ02
NOMESCO Finland
Muscle biopsy of heart
33.9
13.4
17
5
XA800
NOMESCO Finland
Neuropsychological investigation
2.6
13.3
105
432
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
18.2
13.3
20
11
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
5.8
13.2
37
65
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.6
13.2
38
69
TAB00
NOMESCO Finland
Lumbar puncture
3.4
13.2
64
193
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
9.7
13.1
26
27
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
7.1
12.9
31
44
C09AA02
ATC
enalapril; systemic
3.4
12.8
62
186
XX4BW
NOMESCO Finland
NA
8.1
12.7
28
35
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.9
12.7
221
1294
UDC00
NOMESCO Finland
Ear microscopy
2.6
12.6
98
399
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
12.6
129
609
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
31.9
12.5
16
5
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
31.9
12.5
16
5
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
8.2
12.4
27
33
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
13.1
12.3
21
16
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
12.2
717
6016
ZX114
NOMESCO Finland
Intramuscular
5.4
12.1
36
68
783
NOMESCO Finland
NA
37.3
12.1
15
*
C07AB02
ATC
metoprolol; systemic
3.0
12.0
69
235
K03.28
ICD-10 Finland
Other erosion of teeth
6.1
12.0
32
53
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.4
11.9
42
96
N18.0
ICD-10 Finland
End-stage renal disease
13.3
11.8
20
15
WW200
NOMESCO Finland
Immunization
4.9
11.8
38
79
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
11.5
362
2531
RK220
NOMESCO Finland
NA
7.5
11.3
26
35
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
4.9
11.2
36
75
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.2
11.1
58
185
XF622
NOMESCO Finland
Measurement of minute volume of heart
8.9
11.1
23
26
GD1LA
NOMESCO Finland
GD
24.9
11.0
15
6
ZX131
NOMESCO Finland
Intrathecal
12.6
11.0
19
15
I15.8
ICD-10 Finland
Other secondary hypertension
12.6
11.0
19
15
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.5
11.0
38
85
K03.29
ICD-10 Finland
Erosion of teeth occupational
6.4
11.0
28
44
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
10.9
93
398
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
2.1
10.9
130
653
B03XA02
ATC
darbepoetin alfa; parenteral
9.2
10.9
22
24
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.6
10.6
30
54
N04.0
ICD-10 Finland
Nephrotic syndrome, minor glomerular abnormality
21.3
10.6
15
7
WW409
NOMESCO Finland
Other aferesis
21.3
10.6
15
7
B01AA03
ATC
warfarin; systemic
3.8
10.4
44
119
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.9
10.4
33
68
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
1.9
10.4
160
891
ZX197
NOMESCO Finland
NA
109.0
10.3
11
*
J05AB01
ATC
aciclovir; systemic
2.0
10.3
136
711
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
10.2
187
1103
3A077
NOMESCO Finland
NA
23.2
10.1
14
6
324
NOMESCO Finland
NA
23.2
10.1
14
6
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
10.0
438
3305
RK110
NOMESCO Finland
NA
6.9
10.0
24
35
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
14.5
9.9
16
11
JJC00
NOMESCO Finland
Allogenic transplantation of liver
39.7
9.9
12
*
RL140
NOMESCO Finland
NA
4.2
9.8
36
86
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
4.7
9.8
32
68
RS121
NOMESCO Finland
NA
4.7
9.8
32
68
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
12.1
9.7
17
14
B07.9
ICD-10 Finland
Verruca simplex
2.9
9.7
60
213
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
25.8
9.7
13
5
IEP02
NOMESCO Finland
Child-centred family therapy
3.3
9.6
47
144
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
54.5
9.6
11
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.6
9.6
32
70
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
5.8
9.5
26
45
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
9.5
112
560
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
9.5
76
316
WX402
NOMESCO Finland
General anaesthesia
1.8
9.4
182
1090
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
10.0
9.4
18
18
2AX05
NOMESCO Finland
NA
+∞
9.3
9
*
JAH00
NOMESCO Finland
Laparotomy
4.9
9.3
29
59
KAB00
NOMESCO Finland
Biopsy of kidney or pelvis of kidney
21.5
9.3
13
6
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
6.2
9.3
24
39
TJF80
NOMESCO Finland
Ostomy education
6.2
9.3
24
39
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
5.8
9.2
25
43
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
9.0
139
775
L04AA05
ATC
[U] tacrolimus; systemic
36.3
8.9
11
*
TK810
NOMESCO Finland
Hemofiltration
15.5
8.9
14
9
TJD20
NOMESCO Finland
Change of gastrostomy tube
5.3
8.9
26
49
U14
ICPC
Kidney symptom/complaint
9.0
8.9
18
20
WW400
NOMESCO Finland
Plasmaferesis
18.4
8.8
13
7
Z49.0
ICD-10 Finland
Preparatory care for dialysis
23.8
8.8
12
5
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
23.8
8.8
12
5
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
8.8
351
2563
B34.9
ICD-10 Finland
Viral infection, unspecified
2.3
8.8
85
390
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
2.9
8.7
51
177
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.5
8.7
613
5092
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
4.4
8.7
30
68
K03.0
ICD-10 Finland
Excessive attrition of teeth
3.8
8.7
35
92
D82
ICPC
Teeth/gum disease
1.5
8.6
354
2596
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
13.9
8.6
14
10
F43.8
ICD-10 Finland
Other reactions to severe stress
3.4
8.5
39
115
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.8
8.4
27
57
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
5.1
8.3
25
49
R4190
NOMESCO Finland
Nutritional therapy
2.0
8.2
111
586
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.0
8.2
107
558
QXB05
NOMESCO Finland
Skin wound assessment, unspecified location
7.0
8.1
19
27
Z94.2
ICD-10 Finland
Lung transplant status
33.0
8.0
10
*
B01.9
ICD-10 Finland
Varicella without complication
3.6
7.9
34
95
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
7.9
50
183
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.0
7.9
43
144
RS210
NOMESCO Finland
NA
7.2
7.9
18
25
K00.68
ICD-10 Finland
Other disturbance in the tooth eruption
2.5
7.8
60
244
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
12.9
7.8
13
10
1XC02
NOMESCO Finland
NA
12.9
7.8
13
10
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
7.8
98
506
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.8
7.7
139
812
K00.39
ICD-10 Finland
Indefinite enamel capacities
14.9
7.6
12
8
G62.0
ICD-10 Finland
Drug-induced polyneuropathy
14.9
7.6
12
8
UKC02
NOMESCO Finland
Cystoscopy
2.7
7.6
49
182
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
7.6
48
175
SFA00
NOMESCO Finland
Small filling
2.0
7.6
102
538
ZX112
NOMESCO Finland
Subcutaneous
4.1
7.6
28
69
YNB20
NOMESCO Finland
Storage of stem cells for transplant
18.2
7.5
11
6
L01BB02
ATC
mercaptopurine; oral
4.3
7.5
26
60
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
24.7
7.5
10
*
JAF10
NOMESCO Finland
Repair of umbilical hernia
4.9
7.5
23
47
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.6
7.5
193
1256
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
2.9
7.5
44
155
K65.0
ICD-10 Finland
Acute peritonitis
9.9
7.4
14
14
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
9.9
7.4
14
14
C10AA03
ATC
pravastatin; oral
5.4
7.4
21
39
G04BE03
ATC
sildenafil; oral
7.0
7.4
17
24
WX1PA
NOMESCO Finland
Total body mineral density measurement with Dual energy X-ray absorptiometry (DXA)
6.4
7.3
18
28
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.7
7.3
50
191
R63.8
ICD-10 Finland
Other symptoms and signs concerning food and fluid intake
7.6
7.3
16
21
N0480, Z940
ICD-10 Finland
NA
+∞
7.2
7
*
Z940, N0480
ICD-10 Finland
NA
+∞
7.2
7
*
7AX01
NOMESCO Finland
NA
8.3
7.2
15
18
J20.5
ICD-10 Finland
Acute bronchitis due to respiratory syncytial virus
9.3
7.2
14
15
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.2
7.1
16
22
A08.1
ICD-10 Finland
Acute gastroenteropathy due to Norovirus
19.8
7.1
10
5
C64.80
ICD-10 Finland
Wilms tumour
19.8
7.1
10
5
130
Kela drug reimbursment
Malignant tumour
3.8
7.0
28
74
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
9.9
6.9
13
13
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.9
105
580
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.8
6.9
112
633
A02BC01
ATC
omeprazole; systemic
1.7
6.9
135
810
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.3
6.9
63
283
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
6.8
67
311
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
4.3
6.7
23
53
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
6.6
6.7
16
24
1XX02
NOMESCO Finland
NA
10.8
6.7
12
11
ZX196
NOMESCO Finland
NA
39.4
6.7
8
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.5
6.7
239
1680
ZX100
NOMESCO Finland
Oral
5.6
6.7
18
32
H66.9
ICD-10 Finland
Otitis media, unspecified
1.6
6.6
197
1324
YNB00
NOMESCO Finland
Excision of bone marrow for transplantation
22.2
6.6
9
*
K03.21
ICD-10 Finland
Erosion of teeth due to: persistent vomiting
22.2
6.6
9
*
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
2.7
6.6
43
162
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
1.9
6.5
96
523
RK230
NOMESCO Finland
NA
5.1
6.5
19
37
R62.0
ICD-10 Finland
Delayed milestone
2.3
6.5
60
270
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
12.1
6.5
11
9
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.2
6.5
31
96
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.3
6.4
22
51
XKD00
NOMESCO Finland
Uroflowmetry
2.4
6.4
51
213
K00.88
ICD-10 Finland
Other disorders of tooth development
68.9
6.4
7
*
TKA05
NOMESCO Finland
Aspiration cytology of kidney
68.9
6.4
7
*
E42
ICD-10 Finland
Marasmic kwashiorkor
68.9
6.4
7
*
K03.2
ICD-10 Finland
Erosion of teeth
3.8
6.4
25
66
J01MA02
ATC
ciprofloxacin; systemic
1.7
6.3
138
855
RK224
NOMESCO Finland
NA
14.1
6.3
10
7
WX1BG
NOMESCO Finland
Total body MRI with high intensity magnet
7.3
6.3
14
19
TQW99
NOMESCO Finland
Other minor procedure on skin
3.2
6.3
30
93
RT150
NOMESCO Finland
NA
3.1
6.2
31
99
JJC50
NOMESCO Finland
Resection of transplanted liver
+∞
6.2
6
*
K65.9
ICD-10 Finland
Peritonitis, unspecified
+∞
6.2
6
*
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.5
6.2
289
2146
K06.10
ICD-10 Finland
Gingival fibromatosis
26.3
6.2
8
*
RS222
NOMESCO Finland
NA
3.2
6.1
30
95
Q20.48
ICD-10 Finland
Single ventricle
12.4
6.0
10
8
H26.3
ICD-10 Finland
Drug-induced cataract
12.4
6.0
10
8

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
106
53
21.46
137.17
48.8
37.8
6.3
7.0
ug/l
1.49
99
48
78
34
24.02
106.37
8.3
9.9
2.4
2.6
mg/l
0.25
62
29
87
66
13.88
90.89
38.5
32.1
141.5
128.3
ug/l
0.49
81
61
229
587
4.51
80.62
15.1
5.4
67.8
54.2
ng/l
1.84
223
565
230
635
4.18
72.99
35.3
13.0
1.3
1.0
mg/l
11.80
224
624
63
53
12.26
61.57
3.0
2.0
—
—
—
0
0
144
351
4.45
53.14
3.7
1.6
70.2
99.5
u/ml
—
8
42
146
364
4.35
52.31
3.7
1.6
—
—
—
0
0
329
1423
2.76
48.66
29.9
7.3
1.3
1.3
mmol/l
0.26
323
1356
48
38
12.87
48.57
3.7
3.3
—
—
—
0
0
195
635
3.41
47.41
5.7
4.1
59.7
66.0
e9/l
1.66
150
398
139
385
3.88
42.92
11.6
6.5
0.3
0.3
g/l
0.42
121
261
242
961
2.85
41.45
6.8
2.4
21.8
22.6
%
0.54
234
882
255
1045
2.78
41.13
6.4
2.3
2.4
2.6
g/l
4.58
246
976
156
494
3.42
39.32
3.4
1.5
206.1
180.9
u/ml
0.45
100
231
234
937
2.81
39.30
10.6
5.2
1.4
1.4
%
0.35
222
886
156
500
3.38
38.55
8.6
5.2
22.4
22.5
s
0.04
145
466
261
1120
2.65
38.20
9.8
4.4
30.7
30.4
s
0.35
261
1102
267
1166
2.61
37.66
6.4
2.4
13.5
14.5
umol/l
1.84
261
1103
63
101
6.41
36.96
2.5
1.7
—
—
—
0
0
245
1068
2.58
34.41
8.8
3.1
302.6
4182.7
umol/l
3.42
238
986
283
1322
2.45
34.28
25.3
8.4
—
—
—
0
0
132
414
3.40
33.61
2.3
1.5
—
—
—
0
0
102
269
3.98
33.56
2.2
1.8
—
—
—
0
0
77
180
4.42
29.68
4.8
3.2
7.9
9.4
%
1.02
65
163
209
916
2.51
28.62
14.6
4.4
6.2
6.0
umol/l
0.06
182
741
73
169
4.45
28.48
4.8
3.2
208.2
384.9
e6/l
3.29
51
115
290
1489
2.21
27.49
25.4
6.6
1.3
1.3
mmol/l
0.20
258
1173
78
196
4.11
27.35
4.8
3.1
1.1
1.6
e9/l
2.61
58
131
74
181
4.21
26.89
5.0
3.2
—
42.7
—
0
6
50
92
5.52
25.46
6.6
4.1
—
—
—
0
0
60
131
4.68
25.15
4.4
3.7
21.5
25.3
umol/l
2.44
60
131
69
170
4.17
24.83
3.0
1.9
—
—
—
0
0
69
170
4.17
24.83
3.0
1.9
—
—
—
0
0
69
171
4.14
24.63
3.0
1.9
—
—
—
0
0
69
171
4.14
24.63
3.0
1.9
—
—
—
0
0
52
103
5.13
24.42
6.6
4.0
—
—
—
0
0
216
1035
2.28
23.90
4.4
2.3
302.4
362.7
nmol/l
4.53
205
978
84
245
3.54
23.81
5.5
3.1
—
—
—
0
0
417
2574
1.92
23.19
16.9
5.8
37.4
38.0
g/l
1.54
404
2416
60
140
4.37
23.16
4.4
3.4
2.4
2.6
mmol/l
0.20
55
131
310
1730
2.03
23.11
7.3
2.7
571.2
597.9
mosm/kgh2o
1.20
280
1479
193
903
2.31
22.50
7.1
2.8
8.9
9.7
g/l
1.74
185
857
327
1895
1.96
21.70
5.1
2.5
—
—
—
0
0
163
723
2.41
21.41
2.7
2.0
5.3
6.8
u/l
1.81
111
497
206
1016
2.20
21.07
3.1
1.4
—
—
—
0
0
430
2746
1.85
21.05
19.5
7.2
—
—
—
0
0
266
1465
2.01
20.25
7.0
2.9
0.7
0.9
e6/l
0.89
189
791
308
1789
1.93
20.07
8.5
2.6
4.9
8.4
e6/l
5.18
284
1547
534
3679
1.78
20.04
19.1
7.4
—
—
—
0
0
67
189
3.63
19.95
4.8
3.0
0.1
0.2
e9/l
3.62
49
148
67
190
3.61
19.80
4.8
3.0
428.1
558.9
e6/l
1.32
49
147
27
34
7.94
19.58
2.6
1.9
—
—
—
0
0
226
1194
2.06
19.20
24.8
6.7
—
—
—
0
0
164
764
2.28
19.16
2.6
1.8
11.1
11.3
iu/l
0.04
115
550
373
2358
1.81
18.36
5.6
2.5
—
—
—
0
0
260
1476
1.93
17.90
7.4
3.0
2.5
3.4
e6/l
1.01
185
805
335
2064
1.83
17.86
5.6
2.9
—
—
—
0
0
45
103
4.41
17.81
15.7
4.6
—
—
—
0
0
289
1705
1.88
17.67
10.7
3.3
7.4
7.4
ph
3.00
47
287
246
1382
1.94
17.42
24.9
6.8
5.0
5.0
kpa
0.49
241
1328
245
1381
1.94
17.15
25.1
6.8
7.4
7.4
ph
0.78
24
49
55
151
3.70
17.05
1.5
1.3
—
—
—
0
0
221
1205
1.98
17.04
24.8
6.9
10.1
9.8
kpa
1.69
215
1158
492
3433
1.70
16.73
7.3
2.7
73.5
68.1
nmol/l
5.61
479
3243
151
719
2.22
16.65
2.7
1.9
1.0
1.1
g/l
0.30
146
684
383
2509
1.74
16.30
9.9
3.2
—
—
—
0
0
378
2471
1.74
16.19
10.2
3.2
0.1
0.2
e6/l
1.35
309
1823
57
168
3.44
15.90
2.9
2.6
—
—
—
0
0
30
54
5.56
15.64
1.0
1.1
—
—
—
0
0
49
133
3.73
15.45
14.9
4.9
—
—
—
0
0
168
858
2.07
15.44
2.6
1.9
—
—
—
0
0
30
55
5.46
15.34
1.0
1.0
—
—
—
0
0
667
5114
1.65
15.26
11.2
5.3
115.2
99.8
u/l
4.70
641
4775
17
16
10.55
15.21
3.1
2.6
—
—
—
0
0
441
3046
1.67
15.20
13.5
5.7
15.0
14.0
umol/l
0.28
421
2796
256
1522
1.83
14.99
1.9
1.7
1.3
1.3
mmol/l
0.17
250
1380
66
223
3.01
14.75
2.6
1.7
46.0
74.4
titre
—
5
27
313
1988
1.74
14.60
8.2
3.9
7.2
8.8
mmol/l
6.96
293
1831
45
120
3.78
14.56
2.4
3.6
79.1
83.2
mmol/l
0.19
37
113
234
1379
1.83
14.01
8.4
3.7
—
—
—
0
0
493
3569
1.61
13.72
5.9
4.1
—
—
—
0
0
654
5087
1.59
13.29
19.9
7.0
0.6
0.5
e9/l
1.90
587
4324
654
5091
1.59
13.21
19.9
7.0
0.0
0.0
e9/l
4.36
588
4335
481
3487
1.60
13.15
34.2
8.5
1.2
1.2
mmol/l
0.57
465
3283
669
5257
1.58
12.81
21.9
7.5
0.2
0.2
e9/l
0.32
610
4565
673
5296
1.58
12.80
19.5
7.0
2.1
2.2
e9/l
0.85
617
4630
505
3723
1.58
12.74
33.1
7.9
1.2
1.2
mmol/l
0.44
472
3348
633
4926
1.57
12.52
5.1
3.0
69.7
51.5
ug/l
2.16
613
4676
50
159
3.18
12.40
13.4
3.5
—
—
—
0
0
385
2678
1.61
12.32
11.3
3.3
33.2
48.7
e6/l
0.52
314
2005
627
4887
1.56
12.18
20.5
7.1
3.1
3.1
%
0.14
610
4633
612
4750
1.55
12.08
20.7
7.2
0.6
0.6
%
1.21
597
4512
145
769
1.97
11.89
2.6
1.5
—
—
—
0
0
29
65
4.46
11.81
1.9
1.6
—
—
—
0
0
629
4926
1.55
11.81
20.7
7.2
8.7
8.1
%
5.68
610
4682
646
5093
1.55
11.74
19.3
6.8
51.4
51.6
%
0.21
631
4858
445
3247
1.56
11.39
12.8
3.8
35.3
64.3
e6/l
1.03
328
2126
29
67
4.32
11.38
5.6
5.5
4140.3
92.3
mg/l
0.48
29
62
722
5856
1.55
11.35
8.8
3.7
—
—
—
0
0
27
59
4.57
11.35
1.4
1.2
—
—
—
0
0
43
132
3.28
11.30
6.0
3.4
—
—
—
0
0
53
185
2.89
11.22
20.9
11.9
—
—
—
0
0
17
24
7.03
11.15
1.2
1.3
—
—
—
0
0
651
5178
1.53
11.08
19.9
7.0
33.5
33.8
%
0.25
634
4929
182
1066
1.80
10.94
2.7
1.6
—
—
—
0
0
31
78
3.97
10.90
2.0
1.4
—
—
—
0
0
42
131
3.22
10.77
2.3
1.9
136.5
129.3
ng/l
0.15
37
124
301
2031
1.61
10.67
5.5
2.5
2.4
2.4
mmol/l
1.19
283
1830
690
5587
1.52
10.57
23.0
8.6
3.5
3.6
e9/l
1.43
620
4735
129
684
1.95
10.56
21.0
10.9
1.1
1.4
mmol/l
3.87
120
619
23
47
4.87
10.46
1.5
1.6
—
—
—
0
0
236
1515
1.66
10.16
6.8
2.9
2.3
1.2
mg/l
1.00
188
1030
320
2213
1.58
10.15
3.7
2.2
—
—
—
0
0
139
766
1.88
10.13
10.6
4.8
1147.9
839.5
ng/l
0.43
125
601
715
5874
1.50
9.89
8.3
3.8
7.7
7.5
mm/h
0.34
686
5457
271
1817
1.60
9.75
7.6
4.2
1.1
1.1
inr
0.06
59
585
84
392
2.19
9.69
6.3
3.3
12.4
7.4
umol/l
0.85
79
314
435
3262
1.49
9.32
6.1
2.8
—
—
—
0
0
18
33
5.41
9.21
10.2
5.0
—
—
—
0
0
567
4489
1.46
9.17
13.8
5.3
5.9
6.1
mmol/l
1.61
520
4071
101
522
1.98
8.90
6.9
4.1
0.2
0.4
%
0.83
38
104
37
121
3.06
8.82
6.7
2.3
17.3
17.8
%
0.47
31
66
13
18
7.15
8.64
2.5
2.1
—
—
—
0
0
23
56
4.09
8.47
1.6
1.7
13.8
18.6
nmol/l
—
5
18
104
555
1.92
8.35
7.6
4.6
0.3
0.5
%
0.74
46
141
98
522
1.92
7.92
7.5
4.7
0.0
0.0
%
0.74
40
118
46
180
2.57
7.90
6.1
3.8
3.5
3.6
e9/l
0.10
46
180
192
1243
1.62
7.86
1.9
1.5
334.1
533.0
titre
1.34
34
210
41
152
2.70
7.83
5.8
4.8
4.8
19.4
u/ml
0.98
41
132
322
2342
1.48
7.76
1.8
1.8
—
—
—
0
0
730
6165
1.43
7.74
4.7
2.8
4.4
4.5
mmol/l
2.29
712
5861
18
39
4.58
7.66
6.3
4.4
231.0
180.6
ug/l
0.48
18
39
585
4757
1.41
7.65
23.6
8.5
0.0
0.0
e9/l
0.56
491
3723
319
2324
1.48
7.60
3.8
2.8
2.6
2.6
mg/l
0.02
285
2053
75
369
2.06
7.59
1.7
1.4
5.8
5.5
ug/l
0.07
65
347
519
4142
1.41
7.51
7.0
3.0
0.0
0.0
estimate
0.00
98
796
691
5796
1.41
7.50
4.5
2.6
1.2
1.1
mmol/l
0.89
668
5481
46
185
2.50
7.48
7.6
4.0
50.6
52.6
%
0.46
46
185
23
62
3.69
7.40
1.0
1.2
—
—
—
0
0
719
6084
1.41
7.34
4.5
2.7
1.4
1.4
mmol/l
0.77
698
5749
179
1158
1.61
7.32
1.8
1.3
20.1
19.5
nmol/l
0.33
169
1026
726
6156
1.41
7.31
4.6
2.8
2.6
2.7
mmol/l
3.10
698
5787
514
4115
1.40
7.21
9.9
4.2
0.0
0.0
estimate
0.00
99
813
23
64
3.57
7.08
1.3
1.3
—
—
—
0
0
668
5605
1.39
7.01
8.5
3.6
217.3
399.5
e6/l
0.27
13
52
636
5295
1.39
6.99
4.7
3.3
34.7
36.6
mmol/mol
7.63
601
5003
512
4120
1.39
6.86
7.1
2.9
0.0
0.0
estimate
0.00
91
774
12
20
5.93
6.73
4.3
2.5
12.2
8.2
%
0.41
12
20
12
20
5.93
6.73
4.3
2.4
—
—
—
0
0
57
266
2.16
6.64
1.7
1.6
0.2
0.3
nmol/l
0.75
48
226
59
280
2.12
6.59
1.2
1.2
—
—
—
0
0
37
143
2.59
6.56
15.4
4.7
1.3
1.8
mmol/l
0.69
19
74
37
143
2.59
6.56
15.4
4.7
4.8
4.9
kpa
0.54
37
143
37
143
2.59
6.56
15.4
4.4
10.7
9.3
kpa
4.11
37
143
76
403
1.91
6.26
6.2
3.1
—
—
—
0
0
969
8757
1.50
6.21
17.5
7.5
25.0
24.5
u/l
0.31
955
8451
113
681
1.69
6.09
2.9
2.3
35.6
28.8
u/l
0.58
98
556
94
539
1.77
6.04
7.9
4.7
0.0
0.0
%
0.12
45
132
32
120
2.66
6.03
1.1
1.3
—
57.0
—
0
5
31
115
2.69
5.97
28.7
17.2
10.7
11.8
%
1.07
31
115
51
238
2.15
5.96
2.7
2.3
—
—
—
0
0
968
8777
1.48
5.79
23.2
8.3
65.1
61.9
umol/l
2.22
968
8772
20
59
3.36
5.68
3.0
1.4
31.9
32.8
pg
0.44
20
59
99
587
1.71
5.67
2.6
2.1
11.1
9.1
nmol/l
0.88
79
490
253
1853
1.43
5.67
3.8
2.5
60.5
57.1
u/l
0.26
242
1725
44
198
2.22
5.64
1.1
1.3
—
4.3
—
0
20
14
32
4.33
5.60
1.8
2.1
—
—
—
0
0
19
55
3.43
5.55
2.2
2.1
38.4
46.1
%
—
8
16
225
1620
1.45
5.52
1.9
1.6
—
—
—
0
0
422
3387
1.35
5.39
2.1
1.6
1.7
1.7
g/l
0.37
262
1810
43
198
2.17
5.23
4.7
2.2
129.6
134.4
g/l
0.76
36
159
27
101
2.66
5.15
1.0
1.2
—
—
—
0
0
38
169
2.24
5.03
1.3
1.3
2.7
4.0
u/ml
1.00
19
85
112
709
1.61
5.00
1.5
1.3
—
—
—
0
0
84
496
1.71
4.91
1.5
1.2
—
—
—
0
0
1030
9525
1.51
4.89
29.5
11.3
38.8
39.7
%
5.11
918
8300
708
6181
1.31
4.78
3.1
2.5
5.3
5.4
mmol/l
0.61
670
5719
75
439
1.72
4.54
16.3
12.5
-0.6
0.2
mmol/l
0.91
58
338
7
5
13.79
4.52
4.7
1.6
6.1
10.4
mmol/l
—
7
5
74
436
1.71
4.38
16.4
12.6
14.9
15.4
kpa
0.27
69
419
74
437
1.70
4.35
16.5
12.6
5.3
5.2
kpa
0.45
69
419
339
2705
1.32
4.33
1.9
1.7
—
—
—
0
0
75
447
1.69
4.27
1.8
1.2
—
—
—
0
0
64
366
1.76
4.22
1.7
1.5
0.2
0.2
g/l
0.16
64
354
13
36
3.57
4.08
4.0
2.2
0.3
0.2
e9/l
0.21
13
36
25
102
2.43
4.05
2.9
1.7
7.3
2.0
ug/l
0.62
20
87
138
959
1.47
4.05
5.4
2.9
611.8
901.9
ng/l
0.55
83
476
105
690
1.54
4.03
1.2
1.2
—
—
—
0
0
89
563
1.59
4.02
1.5
1.4
—
—
—
0
0
31
140
2.20
4.01
1.1
1.2
—
—
—
0
0
64
375
1.71
3.89
1.7
1.5
1.1
1.2
g/l
1.53
64
360
992
9192
1.39
3.84
22.7
9.1
19.0
21.5
mg/l
2.00
763
6389
981
9078
1.37
3.79
30.5
11.8
334.6
334.3
g/l
0.46
973
8979
140
995
1.43
3.66
2.0
1.4
427.5
311.4
u/ml
0.22
131
930
422
3534
1.27
3.60
2.1
2.2
—
—
—
0
0
13
40
3.21
3.51
1.9
1.1
—
—
—
0
0
13
40
3.21
3.51
1.9
1.1
—
—
—
0
0
13
40
3.21
3.51
1.9
1.1
—
—
—
0
0
893
8189
1.29
3.40
30.6
9.3
139.5
139.5
mmol/l
0.53
872
7912
125
886
1.43
3.33
1.3
1.5
510.7
17237437.2
pmol/l
0.80
117
789
16
58
2.73
3.30
1.8
1.3
—
—
—
0
0
32
161
1.97
3.19
12.8
5.1
—
—
—
0
0
13
43
2.99
3.14
17.2
5.5
—
—
—
0
0
891
8202
1.27
3.07
30.9
9.3
3.9
3.9
mmol/l
3.07
863
7882
13
44
2.92
3.03
2.0
3.4
11.9
26.6
mg/l
—
6
21
26
124
2.08
3.00
2.2
2.3
—
—
—
0
0
9
21
4.22
2.94
1.9
1.3
—
—
—
0
0
50
298
1.67
2.92
1.3
1.1
—
—
—
0
0
126
923
1.38
2.80
1.5
1.5
—
—
—
0
0
14
52
2.66
2.78
1.5
1.3
—
—
—
0
0
14
52
2.66
2.78
3.1
2.3
—
—
—
0
0
1007
9459
1.32
2.68
15.5
7.6
—
—
—
0
0
6
10
5.90
2.66
1.5
1.0
—
—
—
0
0
29
153
1.88
2.57
5.8
2.8
—
—
—
0
0
45
272
1.65
2.53
7.6
3.0
—
—
—
0
0
13
49
2.62
2.52
2.6
2.2
16.0
16.5
umol/l
0.05
13
49
46
280
1.64
2.52
1.3
1.2
0.2
0.8
u/ml
—
5
15
5
7
7.02
2.51
1.2
2.3
—
—
—
0
0
6
11
5.37
2.50
2.8
1.5
—
—
—
0
0
46
282
1.62
2.46
9.5
7.2
1.3
1.2
inr
—
6
65
185
1468
1.28
2.38
3.9
2.2
327.9
303.8
u/l
0.06
177
1416
6
12
4.92
2.36
2.0
1.8
—
—
—
0
0
193
1541
1.27
2.36
1.2
1.2
—
—
—
0
0
20
96
2.06
2.32
1.3
1.1
—
—
—
0
0
938
8774
1.24
2.30
32.9
12.0
13.3
13.1
%
3.73
922
8611
249
2059
1.24
2.25
1.7
1.6
101.1
97.5
pmol/l
0.72
123
1127
382
3303
1.20
2.19
1.8
1.7
—
—
—
0
0
223
1827
1.24
2.19
4.1
3.1
150.1
94.4
ug/g
0.87
195
1431
126
963
1.32
2.16
4.8
3.8
167.6
165.3
mg/l
0.01
96
739
13
54
2.37
2.11
2.0
3.0
1350.5
933.7
u/ml
0.42
13
54
254
2119
1.22
2.10
8.2
3.1
0.0
0.0
estimate
0.80
93
795
24
128
1.86
2.10
1.8
1.3
281.4
270.0
titre
—
7
24
9
30
2.95
2.10
2.4
1.2
—
—
—
0
0
45
289
1.55
2.03
1.4
1.3
—
—
—
0
0
27
152
1.76
2.00
1.4
1.3
0.4
0.4
g/l
0.29
22
129
445
3925
1.18
2.00
2.8
2.2
—
—
—
0
0
6
15
3.93
2.00
1.0
1.1
—
—
—
0
0
21
109
1.90
2.00
1.0
1.0
1.5
1.4
g/l
0.77
21
103
862
8032
1.20
1.99
4.6
4.2
1.9
1.9
mu/l
0.44
828
7593
27
153
1.75
1.96
1.4
1.3
—
—
—
0
0
41
261
1.56
1.93
25.6
16.4
—
—
—
0
0
240
2008
1.22
1.93
10.6
4.1
—
—
—
0
0
29
170
1.69
1.89
1.1
1.1
—
—
—
0
0
35
217
1.60
1.85
2.2
1.5
0.7
0.7
g/l
0.03
29
186
28
165
1.68
1.80
3.3
6.8
—
—
—
0
0
117
910
1.29
1.79
1.1
1.2
—
49.8
—
0
8
7
23
2.99
1.76
1.4
1.3
138.1
132.7
nmol/l
—
7
23
18
93
1.91
1.76
2.2
1.4
0.6
0.7
u/ml
—
8
16
44
292
1.50
1.74
25.5
15.2
0.7
0.7
%
0.64
44
292
24
139
1.71
1.65
1.5
1.7
—
—
—
0
0
5
14
3.51
1.58
2.0
1.4
—
—
—
0
0
418
3730
1.15
1.54
1.6
1.7
3.7
2.9
u/ml
0.24
60
780
32
204
1.55
1.54
10.2
3.6
—
—
—
0
0
10
44
2.24
1.47
1.0
1.2
—
—
—
0
0
44
304
1.43
1.46
7.8
2.8
483.7
385.1
mg/l
0.21
44
294
1102
10611
1.33
1.40
32.6
13.5
6.7
6.8
e9/l
1.12
1077
10180
61
451
1.34
1.38
1.6
1.5
—
—
—
0
0
31
202
1.52
1.38
1.3
1.4
355.5
357.1
ug/g
0.01
15
106
13
66
1.94
1.36
1.2
1.1
—
—
—
0
0
29
187
1.53
1.36
1.7
1.5
18.3
10.6
u/l
0.70
23
163
36
244
1.46
1.34
2.5
1.8
14.2
4.8
ug/l
0.96
29
210
1100
10597
1.31
1.32
32.5
13.5
87.5
87.3
fl
0.97
1087
10442
1100
10599
1.30
1.30
32.5
13.5
29.4
29.3
pg
1.07
1087
10446
33
222
1.47
1.28
1.4
1.5
—
—
—
0
0
1100
10601
1.30
1.28
32.6
13.5
4.5
4.6
e12/l
7.11
1075
10163
8
34
2.31
1.27
2.9
2.3
—
—
—
0
0
1099
10591
1.30
1.27
32.7
13.6
264.8
268.4
e9/l
1.02
1077
10175
13
68
1.88
1.26
3.4
2.4
4.1
2.9
nmol/l
0.30
13
63
8
35
2.25
1.25
2.9
2.3
106.5
105.9
mmol/l
—
8
35
99
796
1.24
1.21
1.5
1.6
274.8
336.7
mu/l
2.62
91
717
37
258
1.42
1.21
1.2
1.4
6.0
4.1
u/ml
0.23
22
163
1100
10608
1.29
1.21
33.0
13.7
131.7
133.9
g/l
5.64
1088
10461
41
292
1.39
1.19
8.4
2.8
4.4
15.7
e6/l
0.77
35
220
8
37
2.13
1.19
2.9
2.2
4.5
3.9
mmol/l
—
8
37
260
2284
1.15
1.18
6.5
2.6
—
—
—
0
0
41
293
1.39
1.17
8.4
2.9
333.0
262.8
e6/l
0.09
35
228
8
39
2.02
1.12
8.9
3.7
—
—
—
0
0
5
20
2.46
1.12
6.2
3.7
4.5
4.5
mmol/l
—
5
20
5
20
2.46
1.12
1.6
1.6
—
—
—
0
0
10
50
1.97
1.11
1.1
1.1
—
—
—
0
0
130
1089
1.19
1.08
1.3
1.3
532.0
269.8
titre
—
5
46
21
134
1.55
1.06
1.2
1.5
—
—
—
0
0
82
972
0.81
1.03
1.2
1.3
89.3
149.7
iu/ml
0.78
27
332
117
978
1.19
1.00
5.6
4.5
156.1
10.9
mg/mmol
0.60
88
742
63
496
1.26
0.96
1.3
1.1
—
—
—
0
0
9
50
1.77
0.94
1.1
1.2
—
—
—
0
0
283
2537
1.12
0.94
1.8
1.7
—
—
—
0
0
6
26
2.27
0.94
2.3
2.7
641.7
577.6
ml
—
6
18
6
26
2.27
0.94
2.5
2.6
556.2
551.4
min
—
6
18
51
394
1.28
0.92
7.0
3.8
—
—
—
0
0
15
92
1.61
0.91
1.2
1.1
—
—
—
0
0
756
7144
1.11
0.90
4.0
3.7
14.5
14.3
pmol/l
0.87
699
6532
34
249
1.35
0.89
1.2
1.4
6.0
11.3
u/ml
0.45
19
145
46
571
0.78
0.89
2.2
2.5
—
—
—
0
0
138
1186
1.16
0.87
1.3
1.2
19.3
16.7
iu/ml
0.14
37
288
13
78
1.64
0.86
1.1
1.2
—
—
—
0
0
88
730
1.20
0.85
1.6
1.4
—
—
—
0
0
64
514
1.23
0.85
1.5
1.5
—
—
—
0
0
15
94
1.57
0.84
1.4
1.2
—
—
—
0
0
6
111
0.53
0.83
1.3
1.2
—
—
—
0
0
24
168
1.41
0.82
1.1
1.1
—
—
—
0
0
11
64
1.69
0.81
1.2
1.1
—
—
—
0
0
64
518
1.22
0.80
1.5
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
11
170
0.63
0.76
1.5
1.3
87.1
48.5
pmol/l
0.48
11
160
59
478
1.22
0.74
2.6
2.2
—
—
—
0
0
78
650
1.19
0.74
1.6
1.4
—
—
—
0
0
5
24
2.05
0.73
1.4
1.4
—
—
—
0
0
5
24
2.05
0.73
1.4
1.2
—
—
—
0
0
21
147
1.41
0.73
1.7
2.1
0.4
0.6
ug/l
1.58
12
69
17
114
1.47
0.73
1.2
1.4
34.7
31.2
nmol/l
0.22
17
104
7
38
1.81
0.73
1.1
1.6
—
—
—
0
0
76
633
1.19
0.72
1.3
1.6
1071.5
1089.7
nmol/l
0.06
58
496
7
39
1.76
0.71
1.3
1.3
—
—
—
0
0
71
818
0.84
0.71
2.1
2.6
—
—
—
0
0
64
526
1.20
0.71
1.5
1.5
—
—
—
0
0
30
226
1.31
0.69
1.2
1.1
—
—
—
0
0
7
41
1.68
0.68
1.9
1.2
—
—
—
0
0
7
41
1.68
0.68
1.4
2.4
3.6
2.2
nmol/l
—
7
41
42
332
1.25
0.67
2.3
1.6
—
—
—
0
0
109
1206
0.87
0.66
1.7
2.0
—
—
—
0
0
10
61
1.61
0.64
3.5
1.7
—
—
—
0
0
21
152
1.36
0.63
1.1
1.1
—
—
—
0
0
6
100
0.59
0.62
1.2
1.8
—
—
—
0
0
13
86
1.49
0.61
1.3
1.2
—
—
—
0
0
0
19
0.00
0.60
0.0
1.2
—
—
—
0
0
88
760
1.15
0.57
8.8
3.2
—
—
—
0
0
25
190
1.30
0.56
1.2
1.2
2.6
22.7
u/ml
0.95
15
153
8
54
1.46
0.56
1.3
1.3
—
—
—
0
0
73
624
1.16
0.55
2.8
3.4
4.9
4.9
pmol/l
0.10
68
575
26
200
1.28
0.54
1.1
1.2
0.8
2.3
u/ml
—
6
60
112
1214
0.89
0.52
1.7
1.9
—
—
—
0
0
6
39
1.51
0.52
1.5
2.2
—
—
—
0
0
6
39
1.51
0.52
3.0
4.5
—
—
—
0
0
13
90
1.42
0.51
1.5
1.7
389.6
502.1
pmol/l
—
8
74
13
90
1.42
0.51
1.0
1.1
—
—
—
0
0
211
1934
1.08
0.48
6.6
2.8
1.0
1.0
kg/l
0.25
36
318
113
1218
0.90
0.48
1.7
2.0
—
—
—
0
0
14
185
0.74
0.48
1.4
1.7
—
—
—
0
0
23
283
0.79
0.48
1.8
2.4
2.0
0.5
nmol/l
1.61
18
244
105
1132
0.90
0.45
1.7
2.0
—
—
—
0
0
112
1201
0.90
0.44
1.7
1.9
—
—
—
0
0
13
93
1.37
0.44
1.2
1.2
—
—
—
0
0
9
125
0.70
0.43
1.4
1.6
209.9
162.8
pmol/l
—
9
119
10
68
1.45
0.43
5.1
4.0
10.6
11.1
mg/l
—
10
59
38
316
1.18
0.42
1.6
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
36
299
1.19
0.41
3.4
2.1
—
—
—
0
0
10
69
1.42
0.40
1.3
1.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
15
112
1.32
0.40
2.6
1.3
—
—
—
0
0
0
18
0.00
0.39
0.0
1.2
—
—
—
0
0
0
18
0.00
0.39
0.0
4.1
—
0.5
—
0
18
5
34
1.44
0.39
9.6
5.4
—
—
—
0
0
18
139
1.27
0.39
1.0
1.0
—
—
—
0
0
5
35
1.40
0.38
1.0
1.0
—
—
—
0
0
89
956
0.91
0.38
1.3
1.2
—
—
—
0
0
268
2506
1.06
0.37
1.8
1.8
—
—
—
0
0
10
132
0.74
0.36
1.0
1.0
—
—
—
0
0
18
141
1.26
0.35
1.0
1.0
19.7
19.4
mmol/l
0.18
18
136
25
204
1.21
0.35
1.1
1.1
—
—
—
0
0
20
238
0.82
0.34
1.1
1.2
—
—
—
0
0
11
81
1.33
0.32
1.1
1.1
—
—
—
0
0
25
206
1.19
0.32
2.9
3.1
2.0
5.9
ug/l
0.88
16
134
17
134
1.25
0.32
1.8
1.2
—
—
—
0
0
7
52
1.32
0.31
4.4
3.3
—
—
—
0
0
7
53
1.30
0.30
1.4
1.0
—
—
—
0
0
44
484
0.89
0.30
1.5
1.4
—
—
—
0
0
23
266
0.84
0.30
1.9
1.9
3.8
5.0
iu/l
—
9
99
8
66
1.19
0.26
1.3
1.2
—
—
—
0
0
41
447
0.90
0.25
1.0
1.1
2.4
7.3
u/ml
3.13
23
235
13
104
1.23
0.23
1.0
1.0
—
—
—
0
0
5
39
1.26
0.22
1.4
1.3
—
66.2
—
0
5
7
92
0.74
0.22
1.0
1.1
—
—
—
0
0
230
2179
1.04
0.21
2.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
15.6
—
0
10
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
34
300
1.11
0.21
1.5
1.2
—
—
—
0
0
0
13
0.00
0.20
0.0
1.1
—
55.0
—
0
8
128
1197
1.05
0.20
3.0
2.3
6471.8
6462.7
u/l
0.00
40
422
0
14
0.00
0.20
0.0
4.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
34
301
1.11
0.20
1.4
1.2
—
—
—
0
0
9
112
0.79
0.20
1.0
1.2
1.0
12.2
u/ml
—
9
103
62
566
1.08
0.20
2.6
1.9
4.2
4.2
e9/l
0.04
55
507
121
1131
1.05
0.20
1.3
1.2
1.7
7.9
u/ml
3.49
40
392
14
162
0.85
0.19
3.2
3.1
32.9
23.1
mg/l
—
9
109
10
79
1.24
0.19
1.6
1.2
—
—
—
0
0
10
79
1.24
0.19
3.6
2.4
—
—
—
0
0
36
322
1.10
0.18
1.1
1.2
—
—
—
0
0
12
98
1.20
0.18
3.8
2.4
—
—
—
0
0
35
375
0.91
0.17
1.1
1.1
0.3
0.5
u/ml
0.25
17
150
21
231
0.89
0.16
1.3
1.2
—
—
—
0
0
83
774
1.05
0.15
2.8
1.9
2.4
2.4
mmol/l
0.16
74
646
124
1169
1.04
0.15
3.0
2.4
—
—
—
0
0
6
75
0.78
0.15
1.0
1.0
—
7.5
—
0
7
6
75
0.78
0.15
1.3
1.2
—
—
—
0
0
9
77
1.15
0.15
2.4
1.7
3.8
5.8
ug/l
—
9
70
65
673
0.94
0.15
1.1
1.2
8.1
4.2
u/ml
0.24
23
213
23
248
0.91
0.13
1.2
1.2
272.0
211.6
iu/ml
—
5
84
14
155
0.88
0.12
1.2
1.8
—
—
—
0
0
95
965
0.96
0.11
1.7
2.0
—
—
—
0
0
10
113
0.87
0.11
2.7
1.6
12.7
12.9
%
—
10
113
5
44
1.11
0.10
1.2
1.1
—
—
—
0
0
22
200
1.08
0.08
2.3
1.7
—
—
—
0
0
7
62
1.11
0.08
1.0
1.1
1515.9
1539.1
miu/ml
—
7
62
7
66
1.04
0.08
1.1
1.3
—
—
—
0
0
7
82
0.84
0.07
4.0
4.2
3.5
3.8
mmol/l
—
7
70
53
536
0.97
0.06
1.2
1.2
—
—
—
0
0
40
407
0.96
0.05
1.1
1.1
4.9
10.1
u/ml
1.21
23
231
16
147
1.07
0.04
1.2
1.1
—
—
—
0
0
90
869
1.02
0.03
2.1
2.1
—
—
—
0
0
14
143
0.96
0.00
2.0
1.7
—
—
—
0
0
16
153
1.03
0.00
8.5
6.0
—
—
—
0
0
70
689
1.00
0.00
1.2
1.2
3.9
6.7
u/ml
1.12
53
502
59
578
1.00
0.00
1.4
1.3
153.7
249.9
miu/ml
1.20
24
289
77
750
1.01
0.00
1.3
1.2
1.6
2.7
u/ml
0.80
47
460
149
1457
1.00
0.00
2.7
2.3
52.9
16.0
ng/l
1.02
70
507
55
537
1.00
0.00
1.1
1.1
—
—
—
0
0
68
671
0.99
0.00
1.1
1.2
0.7
1.3
u/ml
0.95
49
449
9
91
0.97
0.00
1.0
1.3
1.0
1.4
promille
—
9
72
0
7
0.00
0.00
0.0
1.4
—
36.6
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
0.0
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.86
0.00
1.2
1.8
6.8
5.5
mmol/l
—
5
51
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
0.98
0.00
1.2
1.2
—
—
nmol/l
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
11.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
6
59
1.00
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_MIH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_MIH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_MIH – Molar incisor enamel hypoplasia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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