alopecia areata: Loss of scalp and body hair involving microscopically inflammatory patchy areas.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1040 |
4. Check minimum number of eventsNone |
1040 |
5. Include endpointsNone |
1040 |
6. Filter based on genotype QC (FinnGen only) |
994 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60-L75
- Name in latin
- Alopecia areata
Similar endpoints
↥List of similar endpoints to
Alopecia areata
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7560 | 5187 | 2341 |
| Only index persons | 7028 | 4903 | 2125 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.15 | 0.07 |
| Only index persons | 0.15 | 0.18 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 32.57 | 36.09 | 24.73 |
| Only index persons | 33.86 | 37.07 | 26.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 994 | 783 | 211 |
| Unadjusted period prevalence (%) | 0.24 | 0.28 | 0.10 |
| Median age at first event (years) | 44.65 | 44.63 | 44.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1040
- Matched controls
- 10400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L63.9
ICD-10 Finland
Alopecia areata, unspecified
1055.1
307.7
524
10
L63.8
ICD-10 Finland
Other alopecia areata
2591.7
307.7
446
*
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
187.3
174
*
D07AD01
ATC
clobetasol; topical
5.7
149.5
382
967
S23
ICPC
Hair loss/baldness
35.5
138.5
88
27
D07AC01
ATC
betamethasone; topical
4.8
135.5
621
2472
L63.1
ICD-10 Finland
Alopecia universalis
1290.1
120.3
115
*
L63
ICD-10 Finland
Alopecia areata
164.5
112.8
117
8
D07AC13
ATC
mometasone; topical
4.1
108.3
507
1973
D07AB02
ATC
hydrocortisone butyrate; topical
2.6
47.8
416
2103
TQW80
NOMESCO Finland
Local dermatologic skincare
8.4
46.5
62
78
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
46.0
139
377
E0000UV, ,
ATC
2.5
44.0
542
3189
70400
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia areata (benigna, maligna)
+∞
43.0
41
*
XQ802
NOMESCO Finland
Epicutan test
4.9
42.6
99
218
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
213.2
40.1
41
*
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
44.7
35.2
43
10
H02AB06
ATC
prednisolone; systemic
2.2
34.3
539
3400
D07AA02
ATC
hydrocortisone; topical
2.6
31.3
219
969
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
28.7
155
599
XQ845
NOMESCO Finland
Dermatoscopy
9.0
28.2
35
40
L20.0
ICD-10 Finland
Besnier prurigo
2.9
28.0
144
542
D07AB08
ATC
desonide; topical
2.7
26.2
157
640
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
25.1
254
1312
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.7
23.8
144
588
D07XC01
ATC
betamethasone; topical
2.6
23.0
144
598
L04AD01
ATC
ciclosporin; systemic
6.3
23.0
39
64
E000002, ,
ATC
2.4
21.0
156
702
L04AA01
ATC
[U] ciclosporin
8.0
20.5
28
36
XQ848
NOMESCO Finland
Dermatological photography
5.2
19.9
41
81
D02AE01
ATC
carbamide; topical
2.9
18.8
90
324
E000001, ,
ATC
2.0
18.7
245
1381
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
17.9
239
1353
L64.8
ICD-10 Finland
Other androgenic alopecia
183.0
17.6
18
*
D11AH01
ATC
tacrolimus; topical
6.9
17.5
27
40
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.7
16.4
38
83
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
5.2
14.6
30
59
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.1
14.5
154
798
H03AA01
ATC
levothyroxine sodium; systemic
1.8
14.1
266
1669
XQ800
NOMESCO Finland
Prick test
2.4
14.1
104
464
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
14.1
155
814
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
13.3
134
679
C03DA01
ATC
spironolactone; oral
2.3
13.0
102
467
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.2
13.0
22
36
R06AX22
ATC
ebastine; oral
1.8
12.9
206
1225
E000003, ,
ATC
2.9
12.6
62
226
70401
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia alia sive NUD
+∞
12.5
12
*
R06AE07
ATC
cetirizine; oral
1.6
12.4
492
3731
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
12.1
394
2843
L04AX01
ATC
azathioprine; systemic
3.0
12.1
54
187
D06BX01
ATC
metronidazole; topical
2.1
11.9
117
588
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.8
11.8
59
217
D11AH02
ATC
pimecrolimus; topical
12.7
11.7
20
16
7040B
ICD-9 Finland
Diseases of hair and hair follicles, Alopecia[ALOPECIA AREATA]
+∞
11.5
11
*
R06AX27
ATC
desloratadine; oral
1.6
11.4
344
2427
L70.0
ICD-10 Finland
Acne vulgaris
3.8
11.4
34
91
D11AX14
ATC
[U] tacrolimus
12.0
11.4
20
17
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
35.4
11.3
14
*
D02AX
ATC
Other emollients and protectives
3.1
11.3
46
151
L04AX03
ATC
methotrexate; systemic
2.1
10.9
107
537
L71.8
ICD-10 Finland
Other rosacea
9.7
10.8
21
22
E000006, ,
ATC
2.3
10.5
81
368
J05AB01
ATC
aciclovir; systemic
1.7
10.5
236
1541
D05AX52
ATC
calcipotriol, combinations; topical
2.7
10.4
57
221
UJF32
NOMESCO Finland
Coloscopy
1.7
10.1
226
1473
L71.9
ICD-10 Finland
Rosacea, unspecified
4.4
9.8
24
55
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.6
9.8
23
51
H02AB04
ATC
methylprednisolone; systemic
1.9
9.8
138
786
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
9.7
398
2990
L43.8
ICD-10 Finland
Other lichen planus
4.7
9.6
22
48
H01.0
ICD-10 Finland
Blepharitis
2.2
9.5
83
398
E000007, ,
ATC
2.3
9.2
68
304
D07AC14
ATC
methylprednisolone aceponate; topical
2.5
9.0
57
237
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
8.9
186
1186
A07AA02
ATC
nystatin; oral
2.4
8.9
61
264
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
8.4
187
1212
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
8.4
110
611
L73.8
ICD-10 Finland
Other specified follicular disorders
12.9
8.4
14
11
D11AX15
ATC
[U] pimecrolimus
12.9
8.4
14
11
127
Kela drug reimbursment
Transplant complication
4.7
8.4
19
41
L65.2
ICD-10 Finland
Alopecia mucinosa
+∞
8.3
8
*
N05BB01
ATC
hydroxyzine; systemic
2.2
8.3
74
357
L80
ICD-10 Finland
Vitiligo
8.6
8.3
17
20
D07AB01
ATC
clobetasone; topical
2.8
8.2
40
146
P01BA02
ATC
hydroxychloroquine; oral
2.0
8.1
88
458
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
8.1
81
409
104
Kela drug reimbursment
Thyroid insufficiency
2.1
8.0
73
356
J01AA04
ATC
lymecycline; systemic
1.7
7.9
138
838
A02BC02
ATC
pantoprazole; systemic
1.5
7.8
624
5278
J02AC02
ATC
itraconazole; systemic
1.7
7.8
174
1128
A01AB09
ATC
miconazole; local oral
2.0
7.8
86
451
134
Kela drug reimbursment
General erythroderma
15.2
7.7
12
8
D07BC01
ATC
betamethasone and antiseptics; topical
1.8
7.6
109
623
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.0
7.6
33
113
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
7.6
134
815
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
7.5
172
1122
L04AA06
ATC
mycophenolic acid; systemic
3.9
7.5
21
54
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
80.7
7.4
8
*
R03AC02
ATC
salbutamol; inhalant
1.4
7.4
570
4769
R01AD09
ATC
mometasone; nasal
1.4
7.4
482
3913
L93.0
ICD-10 Finland
Discoid lupus erythematosus
11.0
7.3
13
12
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
7.2
287
2118
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
3.7
7.2
22
60
J01DA01
ATC
[U] cefalexin
1.4
7.2
601
5090
SPAT1229
SPAT
Assessment of need for aid
2.2
7.1
61
291
N03AX16
ATC
[U] pregabalin
1.6
6.9
202
1393
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.5
6.8
41
167
K50.1
ICD-10 Finland
Crohn disease of large intestine
4.1
6.8
18
44
L30.3
ICD-10 Finland
Infective dermatitis
2.7
6.8
36
138
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.7
247
1790
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
6.7
98
564
L29.9
ICD-10 Finland
Pruritus, unspecified
2.8
6.6
31
111
D07CC01
ATC
betamethasone and antibiotics; topical
1.7
6.5
125
777
J01DB01
ATC
cefalexin; oral
1.5
6.5
829
7518
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
6.4
223
1595
L66.1
ICD-10 Finland
Lichen planopilaris
70.3
6.4
7
*
R01AD58
ATC
fluticasone, combinations; nasal
1.5
6.4
265
1965
L40.5
ICD-10 Finland
Arthropathic psoriasis
3.8
6.4
19
51
L68.0
ICD-10 Finland
Hirsutism
18.1
6.3
9
5
L26
ICD-10 Finland
Exfoliative dermatitis
26.8
6.2
8
*
S01AD03
ATC
aciclovir; ophthalmic
2.5
6.2
37
151
H02AB07
ATC
prednisone; oral
1.7
6.2
118
734
A03
ICPC
Fever
1.5
6.1
186
1293
R06AX13
ATC
loratadine; oral
1.6
6.0
166
1129
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
336
3.61
31.75
1.2
1.3
1.33
1.08
u/ml
—
7
30
393
2262
2.19
30.60
1.5
1.3
2.43
1.72
u/ml
0.24
113
600
168
772
2.40
21.59
1.2
1.2
138.27
151.54
iu/ml
0.19
71
305
75
223
3.55
21.44
1.4
1.2
1.88
2.96
u/ml
—
6
24
83
265
3.32
21.23
1.6
1.9
—
—
—
0
0
75
227
3.48
20.86
1.4
1.2
2.97
10.23
u/ml
0.78
14
37
782
6252
2.01
20.65
5.3
3.9
10.82
10.72
mm/h
0.08
737
5806
326
1973
1.95
20.49
1.8
1.5
2.14
2.24
g/l
0.59
210
1212
64
177
3.79
20.34
1.3
1.2
1.73
7.72
u/ml
—
7
12
77
248
3.27
19.41
1.4
1.2
3.78
32.56
u/ml
—
6
14
847
7050
2.09
18.82
5.3
4.1
14.95
14.54
pmol/l
5.39
790
6501
137
627
2.36
17.61
1.5
1.3
637.75
215.02
u/ml
1.71
130
586
556
4180
1.71
15.80
8.5
6.0
29.46
29.49
%
0.02
536
3938
555
4203
1.69
15.07
3.0
2.8
88.35
90.36
ug/l
0.12
523
3912
483
3556
1.67
14.37
2.7
2.3
78.05
75.61
nmol/l
1.23
444
3243
544
4136
1.66
14.24
8.0
5.8
55.33
56.12
%
0.87
525
3891
923
8180
2.14
13.73
6.2
4.8
1.84
1.97
mu/l
0.43
871
7622
497
3727
1.64
13.47
7.4
6.3
1.22
1.22
mmol/l
0.18
413
3167
72
281
2.68
12.90
1.7
1.6
1.13
1.20
g/l
1.42
67
266
56
191
3.04
12.85
1.4
1.2
9.99
44.84
u/ml
—
7
19
620
4956
1.62
12.62
10.7
8.7
3.84
3.96
e9/l
0.96
569
4333
297
2008
1.67
11.75
2.4
2.1
2.58
2.86
mg/l
1.74
267
1718
446
3354
1.58
11.31
6.7
5.8
1.22
1.22
mmol/l
0.15
403
3060
145
811
1.92
10.88
2.1
2.1
367.40
370.30
nmol/l
0.06
132
751
364
2643
1.58
10.56
3.1
3.1
2.34
2.36
mmol/l
1.32
319
2365
423
3180
1.56
10.53
5.4
4.5
36.33
36.29
g/l
0.06
404
2983
25
56
4.55
10.52
2.6
2.9
—
—
—
0
0
120
643
1.98
10.20
4.5
2.9
10.16
10.31
g/l
0.17
114
587
46
161
2.94
10.12
4.7
3.9
4.28
4.21
e9/l
0.07
46
161
46
166
2.85
9.60
5.1
4.2
55.93
57.39
%
0.26
46
166
729
6282
1.54
8.93
9.1
6.8
77.77
76.92
u/l
0.20
700
5915
232
1567
1.62
8.90
1.5
1.6
439.65
36103152.58
pmol/l
2.06
195
1324
179
1139
1.69
8.64
2.3
2.2
14.40
14.10
umol/l
0.23
172
1063
392
2994
1.50
8.60
2.0
1.8
96.17
96.97
pmol/l
0.12
205
1545
25
66
3.86
8.55
1.1
1.1
78.20
57.20
u/ml
—
5
5
301
2182
1.53
8.44
2.4
2.1
135.25
202.09
u/l
1.32
283
2061
334
2487
1.51
8.21
3.3
2.4
54.93
59.43
u/l
0.97
312
2310
195
1312
1.60
7.49
2.8
2.7
2.43
2.44
mmol/l
0.19
173
1160
303
2255
1.48
7.32
5.3
3.5
0.01
0.01
estimate
0.03
128
808
46
201
2.35
6.60
2.4
1.5
—
—
—
0
0
155
1021
1.61
6.46
2.3
2.2
2.44
2.40
g/l
0.36
147
950
144
939
1.62
6.25
2.3
2.2
24.20
23.68
%
0.17
123
820
17
43
4.00
6.18
1.1
1.4
32.60
19.38
u/ml
—
5
8
395
3173
1.39
6.07
9.8
10.2
2.17
1.15
inr
0.48
134
976
545
4625
1.37
5.95
5.2
4.5
6.68
6.48
mmol/l
0.84
507
4251
256
1927
1.44
5.63
1.8
2.0
1.09
0.98
mg/l
0.23
193
1450
50
243
2.11
5.60
1.9
1.6
—
200.00
—
0
9
141
940
1.58
5.57
4.3
3.9
33.71
32.20
%
0.86
102
651
340
2695
1.39
5.55
3.4
3.1
20.00
45.57
ng/l
0.98
205
1597
928
8701
1.62
5.47
15.8
11.6
19.42
21.08
mg/l
0.78
751
6695
485
4101
1.34
5.14
6.9
5.8
9.94
10.74
umol/l
1.07
464
3881
501
4263
1.34
5.06
4.6
3.3
0.03
0.00
estimate
0.71
136
851
170
1206
1.49
5.05
3.1
2.4
115.20
112.89
ug/g
0.05
141
957
502
4275
1.34
5.03
5.6
4.5
0.00
0.00
estimate
0.50
130
822
172
1224
1.49
5.03
1.5
1.7
1187.77
1207.49
nmol/l
0.08
134
924
28
111
2.56
4.99
2.9
2.9
0.83
1.08
%
0.21
23
101
89
552
1.67
4.72
3.3
3.9
79.20
72.83
ng/l
0.44
75
492
503
4313
1.32
4.69
4.5
3.3
0.00
0.01
estimate
0.80
129
794
27
109
2.52
4.65
1.5
1.3
—
—
—
0
0
53
283
1.92
4.63
1.2
1.1
12.58
6.05
u/ml
—
6
41
18
59
3.09
4.53
2.7
3.1
0.25
0.18
e9/l
1.15
13
53
875
8170
1.45
4.53
4.4
3.9
5.73
5.77
mmol/l
0.27
810
7544
12
24
5.05
4.32
1.2
1.1
86.58
97.38
%
0.54
12
24
18
61
2.99
4.29
2.7
3.1
513.23
504.11
e6/l
0.03
13
54
162
1176
1.45
4.26
4.4
3.8
0.83
0.82
mmol/l
0.13
153
1106
81
505
1.65
4.23
1.9
1.6
—
—
—
0
0
83
521
1.64
4.22
3.4
2.5
66.43
66.79
g/l
0.16
75
480
15
46
3.29
4.20
2.1
3.8
1139.47
857.93
u/ml
0.33
15
46
18
62
2.94
4.18
1.1
1.1
1.04
1.07
ratio
—
7
25
86
547
1.62
4.16
1.2
1.3
108.20
30.74
au/ml
—
5
36
50
274
1.87
4.07
1.8
1.6
0.02
0.08
iu/ml
—
8
43
207
1591
1.38
3.92
3.1
2.3
8.12
8.14
e6/l
0.01
192
1424
91
599
1.57
3.83
4.1
3.2
1.23
1.23
mmol/l
0.48
81
514
962
9219
1.58
3.73
12.6
9.2
24.82
25.35
u/l
0.59
937
8922
1014
9861
2.13
3.72
22.8
17.1
267.13
259.84
e9/l
3.30
1004
9628
147
1076
1.43
3.70
2.1
2.7
28.89
29.61
s
1.09
142
1046
207
1609
1.36
3.64
1.3
1.3
18.95
29.41
iu/ml
1.94
64
521
1013
9855
2.07
3.59
22.6
17.1
39.88
40.06
%
0.42
965
9323
221
1739
1.34
3.59
2.8
2.9
1139.70
826.32
ng/l
0.47
187
1442
389
3309
1.28
3.56
4.9
3.4
—
—
—
0
0
1014
9870
2.09
3.56
22.8
17.1
4.50
4.50
e12/l
0.00
1003
9620
1014
9872
2.09
3.52
22.8
17.1
6.70
6.72
e9/l
0.05
1001
9618
284
2324
1.31
3.49
3.3
3.0
54.73
91.23
e6/l
0.42
229
1761
808
7536
1.32
3.47
5.5
4.9
38.90
38.72
mmol/mol
0.20
752
7052
1014
9875
2.07
3.47
22.9
17.2
134.33
134.67
g/l
0.39
1009
9753
261
2120
1.31
3.38
3.3
2.8
0.15
0.44
e6/l
4.69
210
1588
210
1657
1.33
3.33
1.5
1.5
20.48
21.73
nmol/l
0.59
182
1425
19
77
2.49
3.31
1.5
1.3
—
—
—
0
0
12
33
3.67
3.29
1.6
2.5
45.67
102.15
umol/l
—
6
20
911
8675
1.40
3.24
16.0
12.5
139.57
139.64
mmol/l
0.35
894
8445
124
904
1.42
3.20
6.6
6.0
—
—
—
0
0
14
49
2.88
3.20
4.1
1.9
—
—
—
0
0
17
67
2.56
3.13
1.0
1.2
—
—
—
0
0
88
603
1.50
3.12
3.4
3.1
4.52
4.60
pmol/l
0.35
82
531
6
8
7.54
3.06
1.0
1.1
70.93
105.00
ng/l
—
6
8
714
6602
1.26
2.98
3.5
3.5
—
—
—
0
0
9
22
4.12
2.88
2.1
1.6
—
—
—
0
0
245
2012
1.28
2.88
1.6
1.5
—
—
—
0
0
99
707
1.44
2.87
8.1
8.2
11.91
12.75
kpa
0.98
94
683
99
707
1.44
2.87
8.1
8.2
5.21
5.11
kpa
0.46
94
681
228
1856
1.29
2.87
4.7
3.5
1.02
1.02
kg/l
0.36
31
267
910
8701
1.37
2.82
16.0
12.6
3.93
3.93
mmol/l
0.22
894
8449
125
935
1.38
2.80
6.8
5.5
1.07
1.06
mmol/l
0.19
120
868
894
8528
1.34
2.79
4.8
4.3
2.86
2.85
mmol/l
0.13
831
7975
330
2826
1.25
2.71
4.0
3.2
29.09
29.89
u/l
0.33
316
2697
98
708
1.42
2.68
8.2
8.2
1.25
1.20
mmol/l
0.04
85
571
30
162
1.88
2.64
1.7
1.4
—
—
—
0
0
882
8415
1.32
2.61
4.5
3.9
4.77
4.78
mmol/l
0.09
823
7918
100
731
1.41
2.57
4.6
4.5
221.37
253.77
u/l
1.42
94
697
8
20
4.02
2.57
1.1
1.1
—
—
—
0
0
29
159
1.85
2.45
1.4
1.7
12378.95
15524.31
e6/l
0.19
21
126
191
1552
1.28
2.43
1.3
1.3
12.99
11.06
u/ml
0.15
81
622
25
131
1.93
2.42
2.4
1.6
—
—
—
0
0
233
1942
1.26
2.40
3.0
2.5
332.53
4772.57
umol/l
5.71
202
1726
9
27
3.35
2.39
1.1
1.1
—
—
—
0
0
21
104
2.04
2.37
1.5
1.3
—
—
—
0
0
31
176
1.78
2.36
1.2
1.3
—
—
—
0
0
846
8054
1.27
2.36
4.1
3.5
1.21
1.26
mmol/l
1.12
791
7499
9
28
3.23
2.31
1.1
1.2
—
—
—
0
0
107
808
1.36
2.29
8.4
6.9
104.57
104.24
mmol/l
0.38
107
808
10
34
2.96
2.28
1.4
1.2
—
—
—
0
0
10
34
2.96
2.28
1.4
1.2
—
—
—
0
0
64
441
1.48
2.27
1.5
1.5
—
—
—
0
0
8
23
3.50
2.27
1.1
1.1
—
—
—
0
0
32
186
1.74
2.26
1.2
1.4
—
—
—
0
0
29
491
0.58
2.26
1.4
1.5
—
—
—
0
0
27
150
1.82
2.22
1.1
1.1
—
—
—
0
0
267
2279
1.23
2.21
3.2
3.2
7.74
7.65
mmol/l
0.11
230
1963
244
2063
1.24
2.21
4.2
3.7
7.40
17.87
mg/mmol
0.60
149
1260
8
24
3.35
2.18
1.1
1.1
—
—
—
0
0
88
650
1.39
2.16
3.7
4.9
2.20
1.92
mmol/l
0.35
75
538
17
81
2.12
2.13
2.2
1.8
—
—
—
0
0
41
260
1.60
2.12
1.3
1.3
—
—
—
0
0
16
75
2.15
2.09
1.4
1.2
6.29
1.68
u/ml
—
10
34
7
20
3.52
2.05
1.0
1.0
—
—
—
0
0
873
8376
1.26
2.05
4.4
3.9
1.52
1.51
mmol/l
0.31
818
7837
32
192
1.69
2.05
2.0
2.8
4.05
7.78
umol/l
1.44
22
144
49
328
1.52
2.02
2.0
1.8
—
—
—
0
0
8
26
3.09
2.01
2.1
1.2
8.57
7.91
ug/l
—
8
26
61
431
1.44
1.94
1.4
1.5
—
—
—
0
0
115
902
1.31
1.93
3.0
3.1
5.48
6.58
umol/l
0.69
95
766
637
5945
1.18
1.92
3.5
3.0
41.21
41.21
u/l
0.00
606
5639
14
65
2.17
1.88
4.0
2.9
52.78
53.30
%
—
9
57
7
22
3.20
1.88
4.4
5.5
—
—
—
0
0
28
453
0.61
1.87
1.5
1.4
—
—
—
0
0
28
452
0.61
1.85
1.5
1.4
—
—
—
0
0
28
451
0.61
1.84
1.5
1.4
—
—
—
0
0
5
12
4.18
1.82
1.4
1.1
—
—
—
0
0
5
12
4.18
1.82
1.2
1.3
—
—
—
0
0
28
450
0.61
1.82
1.5
1.4
—
—
—
0
0
15
73
2.07
1.81
1.6
1.5
0.67
1.20
promille
—
10
59
16
80
2.02
1.80
1.3
1.1
—
—
—
0
0
16
80
2.02
1.80
1.3
1.1
—
—
—
0
0
16
80
2.02
1.80
1.3
1.1
—
—
—
0
0
138
1123
1.26
1.75
2.0
1.9
—
—
—
0
0
38
249
1.55
1.75
1.2
1.1
—
—
—
0
0
173
1445
1.24
1.75
2.1
2.0
—
—
—
0
0
839
8055
1.22
1.72
13.3
10.2
86.09
87.57
ml/min/173m2
1.17
722
6528
37
243
1.54
1.70
1.7
1.9
—
—
—
0
0
24
141
1.72
1.69
2.8
2.4
16.74
16.25
%
0.22
12
71
8
31
2.59
1.66
1.4
1.2
—
—
—
0
0
8
31
2.59
1.66
1.4
1.2
—
—
—
0
0
36
237
1.54
1.64
1.0
1.1
2.48
3.11
u/ml
0.12
22
129
10
42
2.39
1.62
2.3
1.7
—
—
—
0
0
227
1965
1.20
1.61
3.4
3.2
380.54
328.60
mg/l
0.05
140
1224
10
43
2.34
1.59
1.2
1.1
—
—
—
0
0
80
615
1.33
1.58
3.3
2.4
68.03
70.92
ml/min/173m2
0.24
33
228
7
26
2.70
1.58
1.1
1.2
—
—
—
0
0
7
26
2.70
1.58
2.9
2.2
58.94
94.70
ug/l
—
7
26
64
845
0.74
1.53
1.5
1.5
—
—
—
0
0
27
169
1.61
1.53
1.0
1.0
14.93
5.40
u/ml
0.68
14
84
17
93
1.84
1.52
1.4
1.6
—
—
—
0
0
21
123
1.72
1.51
1.1
1.2
—
—
—
0
0
27
170
1.60
1.50
1.6
1.5
95.40
113.71
u/ml
—
5
28
15
79
1.91
1.50
1.3
1.1
—
—
—
0
0
15
79
1.91
1.50
1.3
1.1
—
—
—
0
0
26
163
1.61
1.47
1.1
1.1
4.48
2.39
u/ml
—
9
74
31
204
1.54
1.44
1.0
1.1
3.13
1.91
u/ml
0.35
19
105
96
769
1.27
1.42
4.2
2.9
—
—
—
0
0
18
103
1.76
1.41
1.3
1.4
—
—
—
0
0
18
103
1.76
1.41
1.3
1.4
—
—
—
0
0
15
81
1.86
1.40
1.1
1.2
47.47
86.47
u/l
0.69
15
76
10
46
2.19
1.40
1.0
1.1
1348.10
1500.07
miu/ml
—
10
46
32
214
1.51
1.39
1.0
1.1
12.30
5.41
u/ml
0.76
21
125
7
29
2.42
1.39
1.1
1.0
—
—
—
0
0
23
142
1.63
1.39
1.3
1.1
213.86
202.83
iu/ml
—
8
36
18
104
1.74
1.37
1.3
1.4
—
—
—
0
0
5
17
2.95
1.36
1.0
1.1
—
—
—
0
0
10
47
2.14
1.34
1.4
1.2
—
—
—
0
0
18
105
1.73
1.33
1.3
1.4
—
—
—
0
0
27
176
1.55
1.32
4.6
3.3
48.80
72.51
mg/l
0.25
22
137
27
176
1.55
1.32
4.6
3.3
21.40
42.77
mg/l
0.63
22
135
6
24
2.51
1.30
2.2
1.4
—
—
—
0
0
18
106
1.71
1.30
1.3
1.4
—
—
—
0
0
18
106
1.71
1.30
2.7
1.6
—
—
—
0
0
26
169
1.55
1.29
2.2
2.5
—
—
—
0
0
24
155
1.56
1.23
1.0
1.1
13.22
7.86
u/ml
0.42
13
63
72
569
1.29
1.21
1.3
1.4
—
—
—
0
0
807
7793
1.16
1.20
17.6
14.0
14.79
14.52
%
0.63
798
7654
19
117
1.64
1.18
2.7
1.7
—
—
—
0
0
184
1609
1.17
1.18
2.2
2.2
—
—
—
0
0
28
190
1.49
1.17
1.5
1.6
47.21
40.79
nmol/l
0.62
28
184
30
207
1.46
1.16
1.1
1.7
14.65
3.73
e6/l
0.48
20
153
30
207
1.46
1.16
1.2
1.8
61.17
203.13
e6/l
1.24
24
159
18
110
1.65
1.16
1.2
1.3
0.58
0.57
nmol/l
0.04
18
104
20
126
1.60
1.15
1.7
1.4
—
—
—
0
0
8
41
1.96
1.09
3.4
1.7
—
—
—
0
0
11
59
1.87
1.07
2.8
1.8
—
—
—
0
0
223
1994
1.15
1.07
2.1
2.2
—
—
—
0
0
10
180
0.55
1.07
3.5
4.1
13.50
24.86
u/ml
—
10
175
132
1132
1.19
1.07
1.5
1.7
1.42
1.38
%
0.22
112
1022
7
33
2.13
1.05
1.7
1.0
—
—
—
0
0
29
204
1.43
1.04
1.3
1.4
—
—
—
0
0
17
106
1.61
1.03
1.1
1.1
—
—
—
0
0
10
53
1.90
1.01
1.0
1.0
—
—
—
0
0
81
978
0.81
1.01
1.7
1.6
—
—
—
0
0
36
265
1.37
1.01
1.2
1.1
—
—
—
0
0
146
1273
1.17
0.98
2.5
2.6
0.59
1.11
e6/l
4.64
89
704
27
191
1.42
0.95
1.3
1.4
355.15
228.67
u/ml
0.99
13
110
21
141
1.50
0.95
1.0
1.0
0.17
0.39
u/ml
—
10
43
93
784
1.20
0.93
2.0
1.8
—
—
—
0
0
36
270
1.35
0.92
2.7
1.9
6.72
4.67
iu/l
0.37
11
108
40
305
1.32
0.91
1.4
1.5
16.01
9.08
u/l
1.59
30
250
235
2133
1.13
0.91
1.8
1.6
—
—
—
0
0
8
42
1.91
0.88
3.4
1.6
—
—
—
0
0
43
548
0.78
0.88
1.6
1.4
—
—
—
0
0
20
137
1.47
0.84
2.6
1.8
—
—
—
0
0
6
112
0.53
0.83
1.5
1.1
97.50
94.91
%
—
6
104
91
775
1.19
0.83
1.9
1.8
—
—
—
0
0
8
48
1.67
0.79
3.4
1.6
—
—
—
0
0
24
174
1.39
0.77
3.0
3.8
24.14
24.83
mmol/l
0.37
24
169
61
504
1.22
0.77
2.4
2.2
7.38
7.64
ug/l
0.05
51
450
31
235
1.33
0.76
1.5
1.4
307.71
308.94
ug/g
0.01
15
137
6
34
1.77
0.76
1.0
1.2
—
—
—
0
0
34
262
1.31
0.75
1.2
1.1
—
—
—
0
0
13
83
1.57
0.75
1.0
1.2
30.94
29.52
mg/l
—
7
63
125
1106
1.15
0.73
4.5
4.2
8.29
2.18
ug/l
0.52
113
995
7
39
1.80
0.72
1.9
2.6
34524.43
41648.85
ug/l
—
7
39
33
256
1.30
0.71
1.8
1.8
—
—
—
0
0
5
26
1.93
0.70
1.0
1.2
—
—
—
0
0
5
26
1.93
0.70
1.4
2.3
—
—
—
0
0
5
26
1.93
0.70
1.4
1.1
36.84
60.73
u/ml
—
5
26
29
221
1.32
0.70
3.3
6.5
8.77
8.62
kpa
0.18
29
214
134
1197
1.14
0.69
2.4
2.8
4.51
4.02
e6/l
0.14
79
630
12
77
1.56
0.68
1.0
1.1
—
—
—
0
0
22
161
1.37
0.68
3.6
2.3
73.87
93.70
ug/min
0.16
16
100
5
27
1.86
0.68
1.2
1.1
0.27
30.47
u/ml
—
5
18
115
1019
1.14
0.67
2.6
1.9
—
—
—
0
0
7
43
1.63
0.67
1.1
1.1
17.86
15.19
u/l
—
7
36
25
188
1.34
0.66
2.5
1.8
—
—
—
0
0
100
881
1.15
0.64
4.2
3.8
20.32
21.31
%
0.32
49
379
35
281
1.25
0.60
1.8
1.9
—
—
—
0
0
14
97
1.45
0.59
2.9
1.6
—
—
—
0
0
15
106
1.42
0.58
1.4
1.4
—
—
—
0
0
6
35
1.72
0.57
1.5
1.2
11.87
13.47
pmol/l
—
6
28
232
2164
1.09
0.56
1.8
1.6
1.49
1.34
mmol/l
0.81
194
1867
78
683
1.15
0.56
3.0
4.2
4.16
16.06
ug/l
1.12
60
543
30
239
1.26
0.55
6.0
7.2
1.18
1.32
mg/l
0.75
30
223
15
107
1.41
0.55
1.7
1.5
—
—
—
0
0
16
116
1.39
0.54
2.8
1.5
—
—
—
0
0
91
808
1.14
0.54
2.5
1.8
—
—
—
0
0
9
65
1.39
0.50
1.8
1.5
—
—
—
0
0
9
65
1.39
0.50
1.8
1.5
—
—
—
0
0
9
65
1.39
0.50
1.8
1.5
—
—
—
0
0
7
45
1.56
0.49
1.1
1.1
100.71
84.10
u/l
—
7
39
145
1334
1.10
0.48
4.3
3.3
999.13
417.95
ng/l
0.45
103
883
423
4069
1.07
0.46
2.7
2.5
—
—
—
0
0
13
94
1.39
0.46
3.1
1.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
49
1.43
0.46
1.1
1.1
—
—
—
0
0
81
724
1.13
0.45
2.7
2.4
33.11
38.34
u/l
0.58
72
606
24
193
1.25
0.43
2.6
1.7
—
—
—
0
0
5
31
1.62
0.43
1.0
1.0
—
—
—
0
0
8
56
1.43
0.42
1.0
1.3
—
—
—
0
0
8
56
1.43
0.42
2.1
1.5
—
—
—
0
0
5
32
1.57
0.42
1.4
1.4
—
—
—
0
0
13
96
1.36
0.41
3.4
1.9
11.43
28.14
mg/l
—
7
30
11
79
1.40
0.41
1.6
1.6
—
—
—
0
0
20
159
1.26
0.40
2.6
2.2
132.00
129.92
g/l
0.12
13
122
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
10
71
1.41
0.39
1.7
1.5
0.96
0.97
g/l
—
10
71
71
637
1.12
0.39
2.6
2.7
0.59
0.71
ug/l
1.26
44
372
42
363
1.16
0.39
1.9
1.7
—
—
—
0
0
5
37
1.35
0.37
1.8
1.6
—
1224680.00
—
0
5
38
328
1.16
0.36
10.7
9.3
25.02
24.42
mmol/l
0.46
38
320
20
162
1.24
0.35
1.6
1.3
—
—
—
0
0
5
80
0.62
0.35
1.4
1.4
—
—
—
0
0
6
45
1.34
0.33
1.3
1.4
96.17
177.23
pmol/l
—
6
45
26
219
1.19
0.33
1.3
1.2
—
—
—
0
0
47
417
1.13
0.32
1.7
1.4
—
—
—
0
0
6
47
1.28
0.32
4.5
2.7
140.67
79.57
nmol/l
—
6
47
18
146
1.24
0.32
2.8
3.2
27.11
34.72
umol/l
1.10
18
135
10
131
0.76
0.31
7.5
6.1
396.20
377.57
umol/l
—
10
118
15
120
1.25
0.30
1.3
1.1
—
—
—
0
0
17
139
1.23
0.29
1.3
1.5
—
—
—
0
0
7
57
1.23
0.29
1.9
1.1
—
—
—
0
0
21
177
1.19
0.27
2.7
1.8
—
—
—
0
0
8
64
1.25
0.27
6.8
3.4
—
—
—
0
0
8
65
1.23
0.27
1.6
1.3
—
—
—
0
0
8
67
1.20
0.26
2.4
2.0
—
—
—
0
0
12
95
1.27
0.26
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
63
586
1.08
0.21
1.3
1.4
21.12
27.15
iu/l
0.94
52
494
0
13
0.00
0.21
0.0
3.0
—
0.92
—
0
13
39
428
0.91
0.20
1.8
1.9
1.91
4.74
mg/l
1.34
24
301
18
155
1.16
0.20
1.3
1.4
—
—
—
0
0
18
155
1.16
0.20
1.3
1.4
—
—
—
0
0
12
99
1.21
0.19
2.4
1.7
—
—
—
0
0
12
99
1.21
0.19
2.4
1.7
—
—
—
0
0
18
207
0.87
0.19
1.2
1.2
—
—
—
0
0
42
456
0.92
0.18
1.7
1.5
356.29
300.90
mu/l
0.40
35
403
7
60
1.17
0.18
1.0
1.1
—
—
—
0
0
37
403
0.92
0.17
2.1
1.9
—
—
—
0
0
7
63
1.11
0.17
1.1
1.4
1.48
1.56
g/l
—
7
63
18
158
1.14
0.16
2.8
1.8
—
—
—
0
0
50
467
1.07
0.16
3.3
5.0
2.03
1.84
mmol/l
0.15
41
340
8
73
1.10
0.15
1.3
1.2
—
—
—
0
0
42
390
1.08
0.15
1.4
1.3
244.84
243.25
miu/ml
0.01
22
196
9
79
1.14
0.15
1.0
1.1
—
—
—
0
0
18
160
1.13
0.14
2.3
1.2
6.14
3.98
u/ml
—
7
63
34
315
1.08
0.13
1.5
1.5
—
—
—
0
0
53
560
0.94
0.13
2.5
2.6
110.54
51.02
u/ml
0.30
53
543
17
154
1.11
0.10
1.2
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
165
1.09
0.08
2.8
7.1
0.45
0.41
u/ml
0.12
11
93
6
56
1.07
0.08
1.0
1.0
285.50
300.66
mg/l
—
6
50
7
64
1.09
0.08
1.3
1.3
63.86
71.98
umol/l
—
7
64
10
88
1.14
0.08
1.9
2.7
21.70
23.53
nmol/l
—
10
82
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
8
74
1.08
0.07
1.1
1.0
—
—
—
0
0
25
265
0.94
0.07
1.2
1.5
61.32
201.55
pmol/l
1.49
25
260
9
100
0.90
0.06
1.0
1.1
—
—
—
0
0
10
90
1.11
0.05
1.1
1.2
—
—
—
0
0
16
149
1.07
0.05
1.4
1.1
—
—
—
0
0
42
406
1.04
0.05
1.5
1.6
—
—
—
0
0
40
387
1.03
0.04
1.4
1.7
—
—
—
0
0
59
576
1.03
0.04
2.5
2.2
5492.84
4747.11
u/l
0.09
16
263
56
548
1.02
0.03
1.0
1.0
—
—
—
0
0
44
430
1.02
0.02
2.4
1.6
—
—
—
0
0
13
138
0.94
0.02
2.4
1.7
—
—
—
0
0
13
138
0.94
0.02
2.4
1.7
—
—
—
0
0
202
2006
1.01
0.02
4.3
3.9
95.32
95.28
%
0.01
194
1947
32
312
1.03
0.02
1.2
1.3
—
—
—
0
0
11
106
1.04
0.00
4.7
2.3
—
—
—
0
0
21
207
1.01
0.00
1.8
1.6
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
79
0.89
-0.00
2.7
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
9.88
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
-0.00
1.1
1.4
—
—
—
0
0
6
66
0.91
-0.00
2.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_ALOPECAREATA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALOPECAREATA | 1.002 [0.85, 1.18] | 0.981 |
| Birth year | 0.996 [0.99, 1.0] | 0.338 |
During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 4322 females with L12_ALOPECAREATA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALOPECAREATA | 0.868 [0.7, 1.08] | 0.206 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1847 males with L12_ALOPECAREATA died.
Mortality risk
Mortality risk for people of age
years, who have L12_ALOPECAREATA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.179% |
| 5 | 0.573% | 1.007% |
| 10 | 1.445% | 2.59% |
| 15 | 2.937% | 4.999% |
| 20 | 5.217% | 8.461% |
Relationships between endpoints
↥Index endpoint: L12_ALOPECAREATA – Alopecia areata
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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