≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Alopecia areata

DOID EFO Endpoint Browser PheWeb

L12_ALOPECAREATA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L63
  • Hospital discharge: ICD-9 — 7040B|7040C
  • Hospital discharge: ICD-8 — 70400
  • Cause of death: ICD-10 — L63
  • Cause of death: ICD-9 — 7040B|7040C
  • Cause of death: ICD-8 — 70400

2 out of 7 registries used, show all original rules.

1003

4. Check minimum number of events

None

1003

5. Include endpoints

None

1003

6. Filter based on genotype QC (FinnGen only)

1003

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60-L75
Name in latin
Alopecia areata

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7560 5187 2341
Only index persons 7028 4903 2125
Unadjusted period prevalence (%)
Whole population 0.12 0.15 0.07
Only index persons 0.15 0.18 0.08
Median age at first event (years)
Whole population 32.57 36.09 24.73
Only index persons 33.86 37.07 26.45

-FinnGen-

Key figures

All Female Male
Number of individuals 1003 781 222
Unadjusted period prevalence (%) 0.23 0.27 0.10
Median age at first event (years) 43.58 43.86 42.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
909
Matched controls
9088
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L63.9
ICD-10 Finland
Alopecia areata, unspecified
1271.8
323.0
454
7
L63.8
ICD-10 Finland
Other alopecia areata
3540.9
323.0
387
*
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
169.2
157
*
D07AC01
ATC
betamethasone; topical
5.1
111.2
518
1884
L63.1
ICD-10 Finland
Alopecia universalis
+∞
100.9
95
*
D07AD01
ATC
clobetasol; topical
5.6
86.8
299
733
L63
ICD-10 Finland
Alopecia areata
113.6
85.7
92
9
D07AC13
ATC
mometasone; topical
4.1
79.8
438
1694
S23
ICPC
Hair loss/baldness
34.3
47.0
61
19
D07AB02
ATC
hydrocortisone butyrate; topical
3.0
45.5
351
1576
70400
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia areata (benigna, maligna)
+∞
38.8
37
*
E0000UV
ATC
NA
2.5
37.3
452
2573
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
187.2
35.0
36
*
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
70.4
30.1
34
5
H02AB06
ATC
prednisolone; systemic
2.2
29.0
451
2782
XQ802
NOMESCO Finland
Epicutan test
5.4
27.4
85
169
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.8
26.3
120
351
D07AA02
ATC
hydrocortisone; topical
2.8
24.6
185
770
TQW80
NOMESCO Finland
Local dermatologic skincare
8.7
23.9
52
63
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
19.8
133
513
L20.0
ICD-10 Finland
Besnier prurigo
3.0
18.8
113
405
D07XC01
ATC
betamethasone, combinations; topical
2.8
18.2
124
482
E000002
ATC
NA
2.6
17.9
144
617
D07AB08
ATC
desonide; topical
2.7
17.5
127
513
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
17.0
180
889
L64.8
ICD-10 Finland
Other androgenic alopecia
+∞
16.7
16
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.7
16.4
122
499
E000001
ATC
NA
2.0
14.7
213
1195
D02AE01
ATC
carbamide; topical
3.1
14.6
84
292
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.4
14.3
131
599
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
7.2
13.9
33
47
L71.8
ICD-10 Finland
Other rosacea
26.2
13.4
18
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
12.5
204
1191
H03AA01
ATC
levothyroxine sodium; systemic
1.8
11.8
228
1410
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
65.8
11.6
13
*
70401
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia alia sive NUD
+∞
11.5
11
*
XQ845
NOMESCO Finland
Dermatoscopy
9.8
11.3
22
23
D11AH01
ATC
tacrolimus; topical
9.4
11.0
22
24
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.5
10.9
51
153
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
10.5
123
627
7040B
ICD-9 Finland
Diseases of hair and hair follicles, Alopecia[ALOPECIA AREATA]
+∞
10.4
10
*
L73.8
ICD-10 Finland
Other specified follicular disorders
32.9
10.3
13
*
R06AX27
ATC
desloratadine; oral
1.7
10.3
282
1922
L80
ICD-10 Finland
Vitiligo
23.7
10.3
14
6
L04AD01
ATC
ciclosporin; systemic
5.1
10.2
31
62
XQ848
NOMESCO Finland
Dermatological photography
5.2
10.1
30
59
E000003
ATC
NA
3.0
10.1
57
196
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
10.0
308
2168
R06AE07
ATC
cetirizine; oral
1.6
9.6
408
3108
D11AX14
ATC
[U] tacrolimus; topical
10.2
9.5
18
18
R06AX22
ATC
ebastine; oral
1.8
9.4
176
1068
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
9.3
153
887
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
5.5
9.3
26
48
D11AH02
ATC
pimecrolimus; topical
13.8
9.2
15
11
L04AA01
ATC
[U] ciclosporin; systemic
6.0
9.1
24
41
UJF32
NOMESCO Finland
Coloscopy
1.7
8.9
190
1200
XQ800
NOMESCO Finland
Prick test
2.2
8.7
89
427
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
8.6
239
1625
D11AX15
ATC
[U] pimecrolimus; topical
16.5
8.6
13
8
R01AD09
ATC
mometasone; nasal
1.5
8.4
414
3234
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.2
8.3
87
425
A07AA02
ATC
nystatin; oral
2.6
8.2
57
227
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.5
8.2
36
105
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.9
8.1
19
28
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
7.8
119
672
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.8
134
787
R03AC02
ATC
salbutamol; inhalant
1.5
7.7
457
3684
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
7.7
163
1023
D05AX52
ATC
calcipotriol, combinations; topical
2.8
7.7
47
173
E000006
ATC
NA
2.3
7.7
70
318
L70.0
ICD-10 Finland
Acne vulgaris
4.2
7.6
27
65
J05AB01
ATC
aciclovir; systemic
1.7
7.6
187
1223
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.2
7.6
22
43
D07AC14
ATC
methylprednisolone aceponate; topical
2.6
7.6
53
212
D06BX01
ATC
metronidazole; topical
2.0
7.5
92
477
L71.9
ICD-10 Finland
Rosacea, unspecified
5.1
7.4
22
44
H01.0
ICD-10 Finland
Blepharitis
2.5
7.4
58
245
C03DA01
ATC
spironolactone; oral
2.2
7.4
71
331
D07CC01
ATC
betamethasone and antibiotics; topical
1.9
7.4
116
663
D02AX
ATC
Other emollients and protectives
3.0
7.3
40
138
J01DA01
ATC
[U] cefalexin; systemic
1.5
7.2
522
4365
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
6.9
97
532
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.9
313
2373
L29.9
ICD-10 Finland
Pruritus, unspecified
3.6
6.8
29
83
L04AX01
ATC
azathioprine; systemic
2.6
6.8
48
193
104
Kela drug reimbursment
Thyroid insufficiency
2.2
6.7
66
313
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.0
6.6
81
420
J02AC02
ATC
itraconazole; systemic
1.7
6.6
151
970
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
6.4
86
464
L65.2
ICD-10 Finland
Alopecia mucinosa
70.3
6.4
7
*
H02AB04
ATC
methylprednisolone; systemic
1.8
6.4
116
691
A02BC02
ATC
pantoprazole; systemic
1.4
6.4
496
4155
P01BA02
ATC
hydroxychloroquine; oral
2.0
6.4
75
384
E000007
ATC
NA
2.3
6.4
59
272
J05AB11
ATC
valaciclovir; oral
1.8
6.2
113
678
N05BB01
ATC
hydroxyzine; systemic
2.2
6.2
61
292
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.3
6.0
28
87

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
267
1182
2.72
39.14
1.5
1.4
337.0
557.3
titre
2.57
54
237
111
326
3.70
32.54
1.2
1.3
1.3
1.1
u/ml
—
7
30
381
2175
2.21
30.53
1.5
1.3
2.5
1.7
u/ml
0.24
109
577
89
288
3.29
22.32
1.2
1.2
—
—
—
0
0
163
750
2.40
20.91
1.2
1.2
141.5
149.9
iu/ml
0.11
69
306
74
222
3.52
20.88
1.4
1.2
1.9
2.9
u/ml
—
6
25
583
4260
1.88
20.64
8.6
6.2
0.2
0.2
e9/l
3.32
538
3764
74
226
3.46
20.32
1.4
1.2
3.0
10.0
u/ml
0.78
14
38
756
6047
2.02
19.99
5.3
3.9
10.9
10.7
mm/h
0.19
712
5620
563
4107
1.85
19.64
8.6
5.9
0.0
0.0
e9/l
1.01
516
3580
561
4089
1.84
19.61
8.6
5.9
0.5
0.5
e9/l
0.13
516
3564
312
1907
1.92
18.92
1.8
1.5
2.1
2.2
g/l
0.80
202
1177
400
2655
1.84
18.70
7.9
6.2
—
—
—
0
0
571
4235
1.81
18.34
8.6
5.9
2.0
2.0
e9/l
0.15
533
3765
814
6789
2.06
17.68
5.4
4.1
15.0
14.5
pmol/l
5.72
759
6258
132
600
2.38
17.26
1.4
1.3
532.0
216.7
u/ml
1.49
125
560
527
3862
1.77
17.20
8.2
6.0
3.3
2.8
%
5.36
502
3598
511
3726
1.76
16.85
8.4
6.1
0.7
0.7
%
1.29
487
3480
527
3890
1.75
16.52
8.6
6.3
8.5
8.2
%
1.31
504
3657
537
4024
1.72
15.60
8.4
6.0
29.7
29.6
%
0.04
512
3769
535
4048
1.69
14.63
3.0
2.8
89.3
91.3
ug/l
0.12
504
3764
525
3983
1.67
13.95
7.9
5.8
55.3
56.1
%
0.86
502
3743
466
3435
1.67
13.80
2.8
2.3
78.0
75.5
nmol/l
1.23
427
3134
479
3612
1.62
12.57
7.4
6.4
1.2
1.2
mmol/l
0.27
392
3046
294
1957
1.71
12.55
7.0
4.2
—
—
—
0
0
884
7875
2.03
12.03
6.3
4.8
1.8
2.0
mu/l
0.41
834
7333
36
97
3.81
11.92
1.4
1.3
—
—
—
0
0
598
4801
1.61
11.80
10.6
8.7
3.8
3.9
e9/l
0.97
547
4199
122
628
2.07
11.64
5.5
4.3
0.9
1.0
%
0.16
38
172
285
1939
1.66
10.97
2.4
2.1
2.6
2.9
mg/l
1.59
258
1658
110
566
2.06
10.49
5.6
4.4
0.0
1.4
%
0.92
31
134
139
777
1.92
10.47
2.2
2.1
367.1
369.9
nmol/l
0.06
127
720
429
3247
1.56
10.46
6.8
5.8
1.2
1.2
mmol/l
0.06
384
2943
140
785
1.91
10.45
1.3
1.2
—
—
—
0
0
114
596
2.03
10.41
5.6
4.4
0.2
0.1
%
0.32
37
155
65
269
2.51
10.38
1.8
1.6
1.1
1.2
g/l
1.25
60
254
45
156
2.97
10.08
4.8
3.9
4.3
4.2
e9/l
0.10
45
156
110
576
2.02
9.99
5.3
4.2
0.5
0.5
%
0.06
29
125
287
2005
1.60
9.75
3.4
3.3
—
—
—
0
0
350
2563
1.56
9.70
3.1
3.2
2.3
2.4
mmol/l
1.34
306
2289
407
3082
1.54
9.70
5.4
4.6
36.3
36.3
g/l
0.00
389
2887
45
161
2.88
9.54
5.2
4.3
56.6
57.3
%
0.12
45
161
225
1500
1.64
9.17
1.5
1.6
440.6
26887224.9
pmol/l
1.57
188
1272
114
629
1.92
8.90
4.6
2.9
10.1
10.3
g/l
0.13
108
574
174
1102
1.70
8.58
2.3
2.2
14.4
14.1
umol/l
0.26
166
1016
11
13
8.54
8.47
1.0
1.2
—
—
—
0
0
293
2119
1.54
8.35
2.4
2.1
137.4
206.5
u/l
1.32
275
2000
702
6075
1.52
8.21
9.1
6.9
77.9
77.0
u/l
0.20
672
5709
378
2896
1.49
8.15
2.0
1.8
95.8
96.9
pmol/l
0.17
198
1504
461
3674
1.47
8.15
12.2
8.9
0.0
0.0
e9/l
1.12
404
3006
323
2403
1.51
8.01
3.3
2.4
54.4
55.4
u/l
0.30
302
2237
145
892
1.73
7.92
1.7
1.6
—
—
—
0
0
23
61
3.84
7.83
2.7
2.8
11.9
11.2
%
0.10
12
33
26
79
3.35
7.28
2.5
2.8
1.2
1.3
e9/l
0.20
17
47
117
700
1.76
7.03
2.6
3.5
—
—
—
0
0
291
2182
1.47
6.74
5.3
3.5
0.0
0.0
estimate
0.04
124
774
87
487
1.86
6.51
2.8
1.9
1.2
1.4
g/l
0.29
82
450
343
2668
1.43
6.50
7.6
6.7
2.3
1.1
inr
0.50
117
828
185
1273
1.56
6.42
2.8
2.7
2.4
2.4
mmol/l
0.20
163
1131
150
994
1.60
6.11
2.3
2.2
2.4
2.4
g/l
0.29
142
921
138
911
1.60
5.71
2.3
2.3
24.2
23.7
%
0.16
118
793
896
8388
1.64
5.52
15.8
11.6
19.6
20.9
mg/l
0.53
723
6462
330
2609
1.39
5.52
3.4
3.1
20.1
45.7
ng/l
0.93
200
1537
169
1178
1.52
5.50
1.6
1.7
1195.1
1204.0
nmol/l
0.04
131
892
523
4455
1.36
5.49
5.3
4.5
6.7
6.5
mmol/l
0.73
486
4096
31
124
2.55
5.41
1.5
1.4
—
—
—
0
0
233
1739
1.44
5.38
4.5
4.1
—
—
—
0
0
28
107
2.66
5.35
2.9
3.0
0.9
1.0
%
0.12
22
88
93
567
1.71
5.25
4.7
3.0
—
—
—
0
0
245
1856
1.42
5.19
1.8
2.1
1.1
1.0
mg/l
0.24
184
1396
271
2098
1.40
5.06
5.5
3.4
7.4
7.4
ph
0.65
71
402
87
529
1.71
4.96
1.6
1.4
—
—
—
0
0
30
124
2.46
4.92
3.9
2.1
—
—
—
0
0
466
3958
1.33
4.73
7.0
5.9
10.0
10.8
umol/l
0.95
445
3741
483
4131
1.33
4.64
5.6
4.5
0.0
0.0
estimate
0.50
126
788
91
572
1.65
4.60
4.1
3.2
1.2
1.2
mmol/l
0.49
81
490
7
5
14.08
4.58
1.3
1.0
—
—
—
0
0
480
4107
1.32
4.57
4.6
3.3
0.0
0.0
estimate
0.44
122
769
640
5706
1.34
4.56
5.1
4.0
—
—
—
0
0
133
917
1.52
4.54
1.6
1.4
—
—
—
0
0
162
1165
1.47
4.50
3.2
2.4
119.7
113.1
ug/g
0.14
133
927
935
8921
1.71
4.44
14.6
10.8
—
—
—
0
0
184
1365
1.43
4.33
1.6
1.7
—
—
—
0
0
484
4170
1.31
4.29
4.5
3.3
0.0
0.0
estimate
0.80
125
762
12
31
3.91
4.26
1.6
2.5
45.7
110.1
umol/l
—
6
18
194
1457
1.41
4.25
3.1
2.5
543.7
546.3
mosm/kgh2o
0.05
173
1239
11
27
4.11
4.17
1.2
1.2
—
—
—
0
0
18
63
2.89
4.07
1.1
1.1
1.0
1.1
ratio
—
7
25
156
1135
1.44
4.07
4.3
3.9
0.8
0.8
mmol/l
0.02
145
1060
80
503
1.64
4.06
3.5
2.5
66.6
66.8
g/l
0.08
73
463
84
537
1.62
3.99
3.3
4.0
78.5
72.9
ng/l
0.36
70
479
24
99
2.46
3.99
1.3
1.6
—
—
—
0
0
124
866
1.49
3.98
1.5
1.3
—
—
—
0
0
140
1005
1.46
3.92
2.0
1.9
—
—
—
0
0
17
59
2.91
3.91
2.8
3.1
0.2
0.2
e9/l
0.91
12
53
144
1044
1.44
3.83
2.1
2.8
28.8
29.6
s
1.32
139
1014
840
7890
1.40
3.73
4.4
3.9
5.7
5.8
mmol/l
0.32
777
7291
17
61
2.82
3.70
2.8
3.1
524.3
504.1
e6/l
0.07
12
54
8
12
6.71
3.68
2.4
1.4
—
—
—
0
0
14
45
3.14
3.66
2.2
3.7
1189.6
851.0
u/ml
0.39
14
45
214
1678
1.35
3.57
2.9
2.9
1168.6
805.5
ng/l
0.55
181
1393
262
2118
1.32
3.55
7.7
6.7
—
—
—
0
0
22
94
2.37
3.43
1.2
1.1
—
—
—
0
0
19
76
2.53
3.39
1.5
1.3
—
—
—
0
0
197
1540
1.35
3.35
3.1
2.3
8.2
7.7
e6/l
0.11
176
1348
11
32
3.46
3.34
3.3
3.7
158.3
262.0
e6/l
—
6
20
977
9516
2.03
3.28
22.9
17.2
266.8
259.6
e9/l
3.07
967
9293
926
8899
1.53
3.22
12.7
9.3
24.9
25.4
u/l
0.58
902
8617
289
2397
1.29
3.20
3.2
2.6
—
—
—
0
0
25
117
2.17
3.18
1.6
1.6
—
—
—
0
0
977
9523
2.00
3.16
22.7
17.1
30.0
30.1
pg
0.68
972
9402
977
9524
2.00
3.14
22.8
17.1
4.5
4.5
e12/l
0.01
966
9284
272
2244
1.29
3.13
3.3
2.9
56.1
86.7
e6/l
0.33
220
1698
779
7290
1.31
3.11
5.6
4.9
38.9
38.7
mmol/mol
0.27
726
6823
251
2052
1.30
3.10
3.3
2.8
0.2
0.4
e6/l
3.61
199
1525
977
9527
1.98
3.09
22.9
17.2
6.7
6.7
e9/l
0.06
964
9285
202
1604
1.32
3.08
1.5
1.5
20.6
21.6
nmol/l
0.42
174
1378
977
9529
1.98
3.05
22.9
17.2
134.3
134.7
g/l
0.45
972
9410
10
29
3.47
3.05
2.1
1.5
—
—
—
0
0
197
1561
1.33
3.04
1.3
1.3
18.7
30.0
iu/ml
1.93
56
492
65
420
1.59
3.01
3.4
2.1
—
—
—
0
0
976
9520
1.94
2.99
22.8
17.1
90.2
90.3
fl
0.69
971
9401
878
8376
1.39
2.96
16.0
12.6
139.6
139.6
mmol/l
0.37
861
8155
85
590
1.48
2.86
3.5
3.2
4.5
4.6
pmol/l
0.65
79
521
38
216
1.79
2.83
1.5
1.3
95.0
80.4
titre
—
6
23
39
225
1.76
2.78
1.5
1.3
—
1510.0
—
0
8
8
19
4.24
2.68
1.1
1.0
—
—
—
0
0
8
19
4.24
2.68
1.1
1.0
—
—
—
0
0
8
19
4.24
2.68
1.1
1.0
—
—
—
0
0
33
183
1.83
2.68
1.2
1.8
—
—
—
0
0
59
385
1.57
2.65
6.2
6.4
—
—
—
0
0
320
2746
1.24
2.59
3.9
3.4
69.8
89.3
e6/l
0.27
236
1854
120
905
1.37
2.57
6.8
5.6
1.1
1.1
mmol/l
0.30
115
839
862
8236
1.33
2.56
4.8
4.3
2.9
2.9
mmol/l
0.13
800
7684
5
7
7.17
2.55
1.0
1.1
—
—
—
0
0
877
8402
1.35
2.55
16.0
12.6
3.9
3.9
mmol/l
0.26
861
8159
28
150
1.89
2.53
1.5
1.8
12933.1
16386.8
e6/l
0.20
20
118
7
16
4.40
2.47
1.0
1.1
—
—
—
0
0
99
731
1.39
2.42
6.1
3.5
—
—
—
0
0
24
124
1.96
2.42
2.0
1.7
0.5
0.9
g/l
1.05
19
93
40
243
1.67
2.41
7.0
5.2
—
—
—
0
0
147
1156
1.32
2.40
1.6
1.5
—
—
—
0
0
849
8119
1.30
2.32
4.5
4.0
4.8
4.8
mmol/l
0.07
792
7627
73
515
1.45
2.30
3.3
3.2
66.8
72.0
e9/l
0.54
60
389
93
687
1.39
2.28
8.5
8.3
1.3
1.3
mmol/l
0.03
82
546
816
7773
1.27
2.25
4.1
3.6
1.2
1.3
mmol/l
0.95
762
7238
223
1871
1.25
2.18
3.0
2.5
335.2
4975.1
umol/l
5.71
191
1651
141
1118
1.30
2.18
1.2
1.2
—
—
—
0
0
54
364
1.51
2.14
1.6
1.7
—
—
—
0
0
24
130
1.87
2.14
2.8
2.4
16.7
16.4
%
0.15
12
66
24
130
1.87
2.14
4.7
3.6
—
—
—
0
0
183
1504
1.27
2.13
1.3
1.3
13.8
11.4
u/ml
0.17
76
607
15
68
2.22
2.11
1.6
1.5
0.7
1.2
promille
—
10
56
85
627
1.39
2.11
3.8
5.0
2.2
1.9
mmol/l
0.25
73
505
52
349
1.52
2.11
1.5
1.6
—
—
—
0
0
29
168
1.75
2.09
4.7
2.8
7.4
7.4
ph
0.58
24
141
14
62
2.28
2.08
4.0
3.0
52.8
51.5
%
—
9
43
235
1995
1.23
2.06
4.4
3.9
7.5
18.4
mg/mmol
0.61
146
1217
79
579
1.40
2.05
2.1
2.8
4.9
4.0
e9/l
1.08
58
479
223
1884
1.24
2.04
4.4
3.3
—
—
—
0
0
50
338
1.50
1.98
2.4
2.3
—
—
—
0
0
31
187
1.68
1.96
2.0
2.9
4.0
7.9
umol/l
1.49
21
140
112
876
1.31
1.92
3.0
3.3
5.6
6.6
umol/l
0.60
92
748
25
143
1.77
1.90
5.0
2.9
1.4
2.5
mmol/l
1.48
14
91
7
22
3.20
1.88
1.9
1.6
—
—
—
0
0
12
52
2.32
1.88
1.0
1.2
—
—
—
0
0
255
2203
1.21
1.87
3.3
3.2
7.8
7.7
mmol/l
0.21
218
1878
212
1798
1.23
1.87
4.8
3.6
1.0
1.0
kg/l
0.25
27
257
841
8083
1.25
1.86
4.4
3.9
1.5
1.5
mmol/l
0.25
787
7550
6
17
3.54
1.84
1.3
2.6
—
—
—
0
0
30
185
1.64
1.77
1.5
1.5
—
—
—
0
0
0
46
0.00
1.71
0.0
1.0
—
—
—
0
0
235
2036
1.20
1.67
3.2
2.8
—
—
—
0
0
14
70
2.01
1.59
1.3
1.2
0.6
1.2
u/ml
—
7
21
35
232
1.53
1.56
5.2
7.7
0.8
0.9
%
1.13
35
216
15
78
1.94
1.54
1.3
1.1
—
—
—
0
0
8
33
2.44
1.54
1.0
1.0
—
—
—
0
0
8
33
2.44
1.54
1.3
1.2
—
—
—
0
0
10
44
2.29
1.53
1.7
3.1
27.3
28.8
umol/l
—
10
44
31
201
1.56
1.52
1.0
1.1
12.8
5.3
u/ml
0.80
20
116
22
356
0.61
1.51
1.5
1.5
—
—
—
0
0
16
86
1.87
1.51
4.5
2.4
—
—
—
0
0
6
21
2.87
1.50
3.5
3.0
29.2
52.7
%
—
6
21
263
2327
1.18
1.46
4.2
2.9
—
—
—
0
0
5
16
3.14
1.44
1.2
1.3
—
—
—
0
0
22
350
0.62
1.42
1.5
1.4
—
—
—
0
0
10
46
2.19
1.40
1.0
1.1
1348.1
1523.8
miu/ml
—
10
46
22
348
0.62
1.39
1.5
1.4
—
—
—
0
0
30
198
1.53
1.39
1.2
1.8
61.2
211.1
e6/l
1.29
24
153
30
198
1.53
1.39
1.1
1.7
14.6
3.8
e6/l
0.48
20
148
90
718
1.28
1.38
3.0
3.1
1.5
1.8
%
1.78
82
650
33
223
1.50
1.37
1.0
1.1
3.2
2.4
u/ml
0.12
16
100
217
1901
1.18
1.36
3.5
3.2
402.4
307.7
mg/l
0.10
131
1173
29
191
1.53
1.36
1.0
1.1
0.8
1.3
u/ml
0.34
14
90
21
128
1.65
1.34
1.5
1.5
—
—
—
0
0
13
68
1.92
1.33
1.2
1.4
—
—
—
0
0
27
176
1.55
1.32
4.8
4.0
—
—
—
0
0
26
169
1.55
1.29
4.8
3.3
21.7
43.8
mg/l
0.63
21
130
26
169
1.55
1.29
4.8
3.3
50.2
73.9
mg/l
0.24
21
132
9
176
0.51
1.29
3.6
4.1
14.1
24.8
u/ml
—
9
171
11
55
2.01
1.27
1.0
1.0
—
—
—
0
0
22
138
1.61
1.27
6.2
3.0
—
—
—
0
0
22
138
1.61
1.27
1.3
1.1
213.9
205.9
iu/ml
—
8
35
24
154
1.57
1.26
1.0
1.0
17.5
6.2
u/ml
—
9
61
83
1026
0.79
1.25
1.3
1.2
—
—
—
0
0
8
36
2.23
1.24
1.3
1.2
—
—
—
0
0
281
2531
1.15
1.23
2.3
2.2
—
—
—
0
0
349
3192
1.14
1.23
2.8
2.5
—
—
—
0
0
28
190
1.49
1.17
1.0
1.1
3.4
3.4
u/ml
—
8
49
17
102
1.68
1.16
1.2
1.5
—
—
—
0
0
14
80
1.76
1.13
1.1
2.1
—
—
—
0
0
7
30
2.34
1.12
1.4
3.5
—
—
—
0
0
99
824
1.22
1.09
1.7
1.4
—
—
—
0
0
5
21
2.39
1.09
2.6
1.1
—
—
—
0
0
8
41
1.96
1.09
1.1
1.2
—
—
—
0
0
10
52
1.93
1.06
1.0
1.0
—
—
—
0
0
86
1037
0.81
1.06
1.3
1.3
—
—
—
0
0
240
2163
1.14
1.04
2.0
1.9
—
—
—
0
0
20
130
1.55
1.03
1.0
1.0
0.2
0.5
u/ml
—
8
35
11
60
1.84
1.03
1.0
1.1
—
—
—
0
0
11
60
1.84
1.03
1.8
1.4
—
—
—
0
0
27
188
1.45
1.02
1.5
1.7
48.4
41.0
nmol/l
0.74
27
181
17
107
1.60
1.00
1.2
1.3
0.6
0.6
nmol/l
0.11
17
102
214
1920
1.15
0.99
2.1
2.2
—
—
—
0
0
11
61
1.81
0.98
5.8
1.7
—
—
—
0
0
24
165
1.47
0.97
3.0
4.0
24.2
25.0
mmol/l
0.32
17
146
39
294
1.34
0.95
1.4
1.5
16.3
9.2
u/l
1.57
29
242
21
141
1.50
0.95
1.1
1.2
—
—
—
0
0
18
117
1.55
0.94
2.7
2.7
—
—
—
0
0
69
563
1.24
0.94
1.2
1.2
—
—
—
0
0
41
313
1.32
0.93
9.2
10.8
—
—
—
0
0
21
143
1.48
0.90
1.0
1.1
14.0
7.9
u/ml
—
10
59
26
186
1.41
0.88
1.3
1.4
303.9
230.0
u/ml
0.70
12
107
15
95
1.59
0.87
1.1
1.3
—
—
nmol/l
—
0
0
13
80
1.63
0.85
2.8
3.7
—
—
—
0
0
68
563
1.22
0.83
7.8
8.5
—
—
—
0
0
30
224
1.35
0.80
1.5
1.4
307.7
312.1
ug/g
0.04
15
131
18
122
1.48
0.80
1.2
1.7
—
—
—
0
0
35
268
1.32
0.80
2.8
1.9
6.7
4.4
iu/l
0.44
11
107
199
1809
1.12
0.77
1.7
1.7
—
—
—
0
0
10
59
1.70
0.76
3.0
2.8
—
—
—
0
0
41
324
1.28
0.76
2.3
3.5
20.2
21.4
s
1.23
27
287
227
2086
1.11
0.73
1.8
1.6
1.5
1.3
mmol/l
0.79
190
1796
15
100
1.51
0.73
1.7
1.7
—
—
—
0
0
5
25
2.00
0.72
2.6
3.9
—
—
—
0
0
358
3370
1.10
0.71
2.1
2.0
—
—
—
0
0
21
151
1.40
0.71
3.9
2.4
78.0
98.3
ug/min
0.16
15
95
7
40
1.76
0.71
1.6
2.3
—
—
—
0
0
15
101
1.49
0.70
1.3
1.2
—
—
—
0
0
18
251
0.71
0.70
1.2
1.3
—
—
—
0
0
19
135
1.42
0.69
1.3
1.2
—
—
—
0
0
34
266
1.29
0.69
3.0
4.5
0.2
0.4
g/l
1.34
11
109
25
187
1.35
0.68
1.2
1.2
—
—
—
0
0
5
27
1.86
0.68
2.4
2.4
—
—
—
0
0
5
27
1.86
0.68
1.6
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.0
—
—
—
0
0
56
469
1.21
0.64
3.2
5.3
5.2
5.1
kpa
0.16
47
441
20
146
1.38
0.64
1.8
1.5
—
—
—
0
0
45
369
1.23
0.64
3.6
3.0
—
—
—
0
0
58
490
1.19
0.62
2.5
2.2
7.7
7.6
ug/l
0.01
48
437
10
63
1.59
0.62
1.0
1.1
0.7
4.2
u/ml
—
5
27
5
30
1.67
0.61
1.6
1.6
—
—
—
0
0
122
1094
1.13
0.61
4.4
4.2
8.4
2.2
ug/l
0.51
110
982
77
669
1.16
0.60
3.0
4.2
4.2
16.3
ug/l
1.12
60
530
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
42
346
1.22
0.58
1.3
1.3
—
—
—
0
0
11
73
1.51
0.56
2.5
2.2
—
—
—
0
0
10
65
1.54
0.55
1.1
1.1
—
—
—
0
0
8
125
0.64
0.54
2.3
2.6
—
—
—
0
0
20
152
1.32
0.52
2.7
2.2
132.0
130.7
g/l
0.07
13
117
54
463
1.18
0.51
3.2
5.3
7.4
7.4
ph
—
9
52
45
380
1.19
0.50
1.1
1.1
—
—
—
0
0
6
41
1.47
0.50
3.0
2.2
—
21.4
—
0
6
10
67
1.50
0.49
1.0
1.1
2.7
1.3
u/ml
—
5
22
12
84
1.43
0.49
1.0
1.2
30.9
29.2
mg/l
—
7
64
38
317
1.21
0.49
2.0
2.7
—
—
—
0
0
127
1161
1.11
0.48
2.4
2.7
4.6
3.8
e6/l
0.23
75
611
71
627
1.14
0.47
2.6
2.8
0.6
0.7
ug/l
1.28
44
370
29
352
0.82
0.45
3.2
5.5
—
—
—
0
0
59
672
0.87
0.45
1.5
1.4
—
—
—
0
0
32
265
1.21
0.45
1.2
1.2
—
—
—
0
0
10
69
1.45
0.44
1.5
1.3
—
—
—
0
0
10
69
1.45
0.44
2.9
2.4
700.8
782.0
e6/l
—
5
26
35
294
1.20
0.43
4.2
3.5
0.6
0.7
%
0.42
35
285
743
7296
1.07
0.42
17.9
14.2
13.5
13.5
%
0.03
734
7146
8
58
1.38
0.41
1.1
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
4.6
3.4
—
—
—
0
0
35
297
1.18
0.40
1.2
1.3
—
—
—
0
0
10
71
1.41
0.39
1.0
1.1
—
—
—
0
0
10
71
1.41
0.39
1.7
1.5
1.0
1.0
g/l
—
10
71
28
233
1.21
0.39
6.3
7.7
1.2
1.3
mg/l
0.61
28
219
56
496
1.14
0.38
1.5
1.2
—
—
—
0
0
9
67
1.35
0.38
3.2
2.5
—
—
—
0
0
8
115
0.69
0.37
1.1
1.3
—
—
—
0
0
18
143
1.26
0.37
1.4
1.2
—
—
—
0
0
6
42
1.43
0.35
3.7
2.6
—
—
—
0
0
6
42
1.43
0.35
1.2
1.6
—
—
—
0
0
6
45
1.34
0.33
2.5
6.2
—
—
—
0
0
6
86
0.70
0.33
2.0
1.6
—
—
—
0
0
6
46
1.31
0.33
4.5
2.7
140.7
79.9
nmol/l
—
6
46
405
3928
1.05
0.33
4.5
3.9
—
—
—
0
0
82
752
1.10
0.32
1.3
1.4
—
—
—
0
0
6
47
1.28
0.32
1.2
1.5
—
—
—
0
0
7
96
0.73
0.31
1.0
2.3
—
—
—
0
0
138
1300
1.07
0.30
4.3
3.3
1039.3
408.4
ng/l
0.48
99
863
23
194
1.19
0.29
6.8
8.8
1.1
1.2
mmol/l
0.30
23
170
22
185
1.19
0.29
2.3
2.3
—
—
—
0
0
9
117
0.77
0.27
6.3
4.4
74.8
63.2
%
—
9
117
10
77
1.30
0.26
3.1
2.8
—
—
—
0
0
16
132
1.22
0.25
7.1
11.0
9.5
11.1
mmol/l
1.23
16
120
10
127
0.79
0.25
7.5
6.2
396.2
382.9
umol/l
—
10
114
9
73
1.23
0.25
1.2
1.2
—
—
—
0
0
61
561
1.09
0.24
1.3
1.4
21.1
27.5
iu/l
1.02
52
477
12
96
1.25
0.24
2.4
1.7
—
—
—
0
0
12
96
1.25
0.24
2.4
1.7
—
—
—
0
0
12
96
1.25
0.24
2.4
1.7
—
—
—
0
0
12
96
1.25
0.24
2.4
1.7
—
—
—
0
0
16
133
1.21
0.24
7.1
11.0
105.8
105.4
mmol/l
0.14
16
121
255
2634
0.96
0.23
1.6
1.6
—
—
—
0
0
103
1090
0.94
0.22
2.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
5.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
2.0
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
29
258
1.13
0.21
9.6
7.9
—
—
—
0
0
0
12
0.00
0.21
0.0
7.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
24
211
1.14
0.20
3.3
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
25
221
1.13
0.20
1.7
2.4
—
—
—
0
0
50
540
0.92
0.19
2.6
2.6
115.9
46.7
u/ml
0.33
50
523
40
436
0.91
0.19
1.7
1.5
360.2
303.2
mu/l
0.40
34
384
59
551
1.08
0.18
2.5
2.2
5492.8
4866.8
u/l
0.07
16
251
7
61
1.15
0.17
1.0
1.2
—
—
—
0
0
10
82
1.22
0.17
4.2
2.9
—
—
—
0
0
5
69
0.72
0.17
1.8
1.1
—
—
—
0
0
16
183
0.87
0.16
1.6
1.3
—
—
—
0
0
19
170
1.12
0.13
1.6
1.7
—
—
—
0
0
76
726
1.05
0.13
15.5
18.4
1.1
1.2
inr
0.60
15
105
16
142
1.13
0.12
5.0
4.8
—
—
—
0
0
35
373
0.94
0.11
1.0
1.1
—
—
—
0
0
17
154
1.11
0.10
2.4
1.2
6.1
4.2
u/ml
—
7
59
10
87
1.15
0.09
1.9
2.6
21.7
23.9
nmol/l
—
10
80
16
145
1.11
0.09
1.1
1.0
—
—
—
0
0
50
523
0.95
0.09
2.4
2.4
—
—
—
0
0
6
54
1.11
0.09
1.0
1.0
285.5
298.3
mg/l
—
6
49
6
54
1.11
0.09
1.5
1.1
—
—
—
0
0
6
55
1.09
0.09
1.5
2.0
—
—
—
0
0
6
58
1.03
0.08
1.0
1.2
—
—
—
0
0
5
61
0.82
0.08
1.4
2.2
—
—
—
0
0
8
77
1.04
0.07
1.0
1.2
—
—
—
0
0
18
194
0.93
0.07
2.0
1.9
—
—
—
0
0
40
383
1.05
0.07
1.4
1.3
223.6
246.2
miu/ml
0.18
20
193
9
102
0.88
0.06
5.4
2.3
—
—
—
0
0
16
148
1.08
0.06
1.1
1.1
—
—
—
0
0
28
266
1.05
0.06
1.0
1.2
—
—
—
0
0
10
90
1.11
0.05
1.2
1.1
—
—
—
0
0
44
454
0.97
0.04
1.6
1.9
—
—
—
0
0
50
487
1.03
0.04
1.6
1.9
—
—
—
0
0
120
1184
1.02
0.04
1.5
1.5
—
—
—
0
0
540
5419
0.99
0.03
3.8
3.2
—
—
—
0
0
68
668
1.02
0.03
1.5
1.4
—
—
—
0
0
50
489
1.02
0.03
1.6
1.9
—
—
—
0
0
60
609
0.98
0.02
2.5
1.7
—
—
—
0
0
49
482
1.02
0.01
1.6
1.9
—
—
—
0
0
194
1948
0.99
0.01
4.2
3.9
95.1
95.2
%
0.02
186
1892
48
484
0.99
0.00
1.6
1.8
—
—
—
0
0
807
8065
1.00
0.00
14.1
12.4
39.4
39.9
%
0.90
580
6284
38
378
1.01
0.00
1.6
2.0
—
—
—
0
0
19
189
1.01
0.00
1.0
1.1
—
—
—
0
0
19
189
1.01
0.00
1.0
1.1
—
—
—
0
0
19
185
1.03
0.00
1.1
1.1
—
—
—
0
0
16
155
1.03
0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
15.6
—
0
7
0
6
0.00
0.00
0.0
1.5
—
25.8
—
0
6
0
7
0.00
0.00
0.0
9.9
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
97.3
—
0
7
7
79
0.89
0.00
1.4
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
4.6
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ALOPECAREATA and mortality.

Females

Parameter HR [95% CI] p-value
L12_ALOPECAREATA 1.002 [0.85, 1.18] 0.981
Birth year 0.996 [0.99, 1.0] 0.338

During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 4322 females with L12_ALOPECAREATA died.

Males

Parameter HR [95% CI] p-value
L12_ALOPECAREATA 0.868 [0.7, 1.08] 0.206
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1847 males with L12_ALOPECAREATA died.

Mortality risk

Mortality risk for people of age

years, who have L12_ALOPECAREATA.

N-year risk Females Males
1 0.093% 0.179%
5 0.573% 1.007%
10 1.445% 2.59%
15 2.937% 4.999%
20 5.217% 8.461%

Relationships between endpoints

↥

Index endpoint: L12_ALOPECAREATA – Alopecia areata

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data