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Perioral dermatitis

DOID EFO Endpoint Browser PheWeb

L12_PERIORALDERM

rosacea: a chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L71.0#
  • Hospital discharge: ICD-9 — 6953B
  • Cause of death: ICD-10 — L71.0#
  • Cause of death: ICD-9 — 6953B

2 out of 7 registries used, show all original rules.

799

4. Check minimum number of events

None

799

5. Include endpoints

None

799

6. Filter based on genotype QC (FinnGen only)

799

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L71
Name in latin
Dermatitis perioralis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4435 3704 720
Only index persons 4253 3606 647
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.02
Only index persons 0.12 0.13 0.02
Median age at first event (years)
Whole population 40.59 40.25 42.27
Only index persons 40.98 40.43 44.06

-FinnGen-

Key figures

All Female Male
Number of individuals 799 713 86
Unadjusted period prevalence (%) 0.22 0.24 0.04
Median age at first event (years) 45.70 44.68 54.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
700
Matched controls
7001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L71.0
ICD-10 Finland
Perioral dermatitis
4503599627370496.0
323.0
698
45
D06BX01
ATC
metronidazole; topical
24.4
263.9
421
407
J01AA04
ATC
lymecycline; systemic
9.3
131.0
325
594
J01AA07
ATC
tetracycline; systemic
6.6
95.6
301
714
L71.9
ICD-10 Finland
Rosacea, unspecified
27.3
55.0
76
31
L71.8
ICD-10 Finland
Other rosacea
54.0
54.0
64
13
E0000UV
ATC
NA
3.3
49.3
406
2059
D10AX03
ATC
azelaic acid; topical
4.6
35.8
136
347
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.3
35.1
145
401
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.3
31.3
183
672
XQ802
NOMESCO Finland
Epicutan test
6.3
30.9
86
152
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.9
29.3
102
235
D10BA01
ATC
isotretinoin; oral
4.7
28.3
103
248
L70.0
ICD-10 Finland
Acne vulgaris
9.7
24.9
51
56
XQ800
NOMESCO Finland
Prick test
3.9
24.8
110
319
E000001
ATC
NA
2.5
20.8
199
962
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
19.7
96
299
L71
ICD-10 Finland
Rosacea
8.4
19.5
43
54
D07AC13
ATC
mometasone; topical
2.2
17.3
236
1337
H02AB06
ATC
prednisolone; systemic
2.0
17.0
336
2207
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
17.0
299
1880
D07AC01
ATC
betamethasone; topical
2.1
16.6
250
1471
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
16.4
228
1296
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
16.1
180
924
L20.0
ICD-10 Finland
Besnier prurigo
3.1
15.5
91
323
R06AE07
ATC
cetirizine; oral
1.9
14.9
355
2458
D07AD01
ATC
clobetasol; topical
2.5
14.9
129
579
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
14.8
191
1043
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
14.4
193
1070
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
13.4
110
479
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.3
12.8
48
119
J02AC01
ATC
fluconazole; systemic
1.8
12.8
359
2579
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
12.6
165
898
D10AF01
ATC
clindamycin; topical
3.4
12.3
61
193
R06AE09
ATC
levocetirizine; oral
2.2
12.0
140
723
D02AE01
ATC
carbamide; topical
3.0
11.7
69
247
P01BA02
ATC
hydroxychloroquine; oral
2.8
11.7
77
296
D07AB08
ATC
desonide; topical
2.5
11.2
92
400
UJF32
NOMESCO Finland
Coloscopy
2.0
11.1
163
921
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
11.0
93
409
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.9
10.8
44
119
R06AX27
ATC
desloratadine; oral
1.8
10.7
240
1574
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
9.4
10.6
21
23
L71.1
ICD-10 Finland
Rhinophyma
+∞
10.4
10
*
L57.0
ICD-10 Finland
Actinic keratosis
3.1
10.1
57
196
L04AX01
ATC
azathioprine; systemic
3.5
10.1
47
142
J01DB01
ATC
cefalexin; oral
1.8
9.5
566
4889
J02AC02
ATC
itraconazole; systemic
2.0
9.4
137
771
R01AD08
ATC
fluticasone; nasal
1.8
9.4
215
1411
R03BA02
ATC
budesonide; inhalant
2.0
9.3
136
767
L70
ICD-10 Finland
Acne
5.7
9.1
25
45
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
9.0
108
562
C01CA24
ATC
epinephrine; parenteral
2.7
9.0
63
249
E000006
ATC
NA
2.7
9.0
63
250
D02AX
ATC
Other emollients and protectives
3.6
8.9
39
113
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.6
200
1310
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
8.5
78
358
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
8.5
94
473
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.7
8.4
58
230
E0001A1
ATC
NA
4.4
8.4
29
68
L43.8
ICD-10 Finland
Other lichen planus
5.9
8.3
22
38
J01DA01
ATC
[U] cefalexin; systemic
1.6
8.2
427
3465
H02AB07
ATC
prednisone; oral
2.1
8.1
95
487
S18
ICPC
Laceration/cut
1.6
8.0
254
1812
L21.0
ICD-10 Finland
Seborrhoea capitis
8.6
7.8
16
19
L30.8
ICD-10 Finland
Other specified dermatitis
4.3
7.8
27
64
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
6.0
7.7
20
34
D07XC01
ATC
betamethasone, combinations; topical
2.3
7.7
73
344
S21
ICPC
Skin texture symptom/complaint
2.1
7.6
88
450
D11AH02
ATC
pimecrolimus; topical
12.0
7.6
13
11
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.7
7.6
24
52
S01AD03
ATC
aciclovir; ophthalmic
3.5
7.5
34
102
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.4
574
5082
R05
ICD-10 Finland
Cough
1.8
7.3
132
795
D11AH01
ATC
tacrolimus; topical
6.9
7.3
17
25
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
7.4
7.2
16
22
D07AA02
ATC
hydrocortisone; topical
1.9
7.1
110
628
A07EC01
ATC
sulfasalazine; oral, rectal
2.4
7.1
61
273
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.1
347
2732
L30.3
ICD-10 Finland
Infective dermatitis
3.6
7.0
30
87
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
6.4
7.0
17
27
ZXC50
NOMESCO Finland
Cryotherapy
5.5
7.0
19
35
R01AD12
ATC
fluticasone furoate; nasal
1.6
6.9
236
1706
S29
ICPC
Skin symptom/complaint other
1.9
6.8
108
620
R03AC02
ATC
salbutamol; inhalant
1.5
6.8
366
2930
L21
ICD-10 Finland
Seborrhoeic dermatitis
6.2
6.8
17
28
L70.1
ICD-10 Finland
Acne conglobata
40.4
6.8
8
*
D07XB05
ATC
dexamethasone, combinations; topical
3.8
6.7
27
74
N03AX16
ATC
pregabalin; oral
1.7
6.7
141
889
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.0
6.7
38
133
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
6.5
6.7
16
25
J01AA02
ATC
doxycycline; systemic
1.6
6.6
507
4389
SPAT1153
SPAT
Removal of sutures
1.6
6.6
188
1293
L82
ICD-10 Finland
Seborrhoeic keratosis
1.9
6.5
93
516
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.3
6.5
30
93
L50.3
ICD-10 Finland
Dermatographic urticaria
4.1
6.3
23
58
L04AA01
ATC
[U] ciclosporin; systemic
5.6
6.3
17
31
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.6
6.3
44
176
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
5.8
6.2
16
28
A02BC05
ATC
esomeprazole; systemic
1.5
6.1
253
1898
TQW99
NOMESCO Finland
Other minor procedure on skin
3.0
6.1
33
114
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
6.1
58
274
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.3
6.1
28
87
R06AX22
ATC
ebastine; oral
1.7
6.1
135
867
WZA10
NOMESCO Finland
Long statement of health and health related matters
5.3
6.0
17
33

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
491
3231
2.35
29.50
8.3
5.3
0.5
0.5
e9/l
2.02
443
2818
490
3247
2.32
28.59
8.3
5.3
0.0
0.0
e9/l
0.40
442
2827
498
3353
2.29
27.53
8.3
5.2
1.9
2.0
e9/l
1.38
458
2978
495
3377
2.22
25.76
8.8
5.5
0.2
0.2
e9/l
1.59
454
2982
461
3058
2.20
25.74
8.3
5.3
2.7
2.7
%
0.08
437
2823
462
3077
2.19
25.41
8.5
5.5
8.3
8.1
%
1.04
440
2863
447
2944
2.18
25.23
8.4
5.4
0.7
0.7
%
1.74
425
2721
467
3156
2.15
24.32
8.0
5.1
55.8
56.5
%
0.71
444
2938
470
3194
2.15
24.00
8.3
5.3
29.6
29.5
%
0.08
448
2961
192
953
2.34
21.25
1.6
1.3
662.9
568.4
titre
0.21
35
201
323
2040
1.98
18.69
8.9
5.4
—
—
—
0
0
510
3782
1.96
18.08
11.0
8.1
3.6
3.9
e9/l
1.99
464
3306
609
4896
2.03
15.93
5.7
3.8
10.8
10.5
mm/h
0.22
564
4558
261
1613
1.92
15.49
5.8
4.0
—
—
—
0
0
75
280
2.85
14.76
1.3
1.3
0.8
0.7
u/ml
—
8
21
594
4815
1.91
14.08
8.7
6.6
72.9
74.8
u/l
0.64
566
4496
386
2789
1.74
13.14
2.7
2.3
82.3
76.1
nmol/l
4.31
355
2554
66
245
2.85
13.12
1.3
1.2
—
—
—
0
0
348
2481
1.71
12.13
6.7
5.5
1.2
1.2
mmol/l
0.62
319
2251
379
2771
1.70
12.00
2.2
2.0
—
—
—
0
0
381
2793
1.70
11.91
7.2
6.1
1.2
1.2
mmol/l
0.26
320
2337
252
1660
1.76
11.55
3.7
3.4
7.4
7.4
ph
0.10
58
329
51
180
2.96
11.11
1.4
1.2
26.2
16.0
u/ml
—
9
33
392
2935
1.66
11.02
12.7
8.2
0.0
0.0
e9/l
0.65
332
2401
50
176
2.96
10.94
1.4
1.2
1.3
3.3
u/ml
—
5
19
128
691
2.01
10.89
1.9
1.5
—
—
—
0
0
130
707
2.00
10.83
1.5
1.4
—
—
—
0
0
559
4632
1.69
10.19
5.0
4.0
—
—
—
0
0
231
1537
1.71
9.97
1.8
1.5
2.3
2.1
g/l
0.52
157
950
148
865
1.87
9.92
2.6
2.1
14.1
13.9
umol/l
0.12
136
793
196
1260
1.74
9.53
1.3
1.3
8.9
10.3
u/ml
0.15
89
505
742
6767
2.35
9.23
15.6
11.0
16.0
19.8
mg/l
3.87
581
5185
125
714
1.89
8.95
2.7
2.2
23.9
23.1
%
0.28
115
605
89
457
2.07
8.64
5.8
4.1
0.3
1.0
%
0.30
18
100
27
76
3.64
8.46
1.6
1.3
—
—
—
0
0
91
476
2.03
8.40
5.8
4.0
0.2
0.1
%
0.07
20
113
90
470
2.03
8.34
5.4
2.8
10.9
10.1
g/l
0.89
85
429
132
784
1.82
8.33
2.6
2.1
2.4
2.4
g/l
0.36
120
716
712
6440
1.97
8.29
5.8
5.0
1.7
2.0
mu/l
0.85
658
6018
94
502
1.99
8.18
1.7
1.2
210.9
219.3
u/ml
0.03
88
462
93
498
1.98
8.03
5.7
3.9
1.0
1.0
%
0.07
22
127
252
1796
1.59
8.01
1.4
1.3
1.2
1.8
u/ml
0.68
71
476
639
5620
1.68
7.91
4.9
4.3
14.5
14.5
pmol/l
0.01
576
5198
140
860
1.76
7.86
1.2
1.2
—
—
—
0
0
70
343
2.14
7.68
2.5
2.9
62.7
72.6
e9/l
1.46
53
250
152
964
1.71
7.61
3.0
2.3
113.1
99.9
ug/g
0.20
123
749
426
3448
1.50
7.37
3.4
2.7
79.9
76.1
ug/l
0.29
395
3224
35
127
2.84
7.31
4.5
4.1
3.6
4.3
e9/l
1.21
35
127
36
133
2.79
7.27
4.8
4.4
53.1
57.8
%
1.16
36
133
113
667
1.81
7.24
1.4
1.3
—
—
—
0
0
85
459
1.95
7.17
5.6
3.8
0.7
0.6
%
0.11
16
96
145
925
1.69
7.08
1.7
1.5
—
—
—
0
0
27
86
3.21
7.04
1.3
1.4
—
25.3
—
0
6
101
584
1.84
6.91
1.4
1.4
—
—
—
0
0
15
32
4.76
6.71
4.2
2.8
818.7
597.8
u/ml
0.31
15
32
309
2375
1.49
6.69
5.6
4.4
36.4
36.4
g/l
0.06
293
2221
189
1316
1.57
6.45
1.4
1.3
21.1
27.3
iu/ml
0.64
66
433
758
7113
2.28
6.45
13.2
8.8
24.9
24.1
u/l
0.60
743
6882
225
1629
1.53
6.44
1.6
1.6
1.3
1.3
mmol/l
0.57
191
1403
214
1536
1.54
6.37
2.5
2.0
2.7
2.8
mg/l
0.45
182
1301
282
2151
1.48
6.25
4.6
3.3
18.0
63.7
e6/l
6.07
196
1413
235
1730
1.51
6.19
3.9
2.9
16.2
102.9
e6/l
1.37
182
1298
21
62
3.45
6.17
2.1
1.3
—
—
—
0
0
87
499
1.83
6.11
2.5
2.8
1.6
1.7
%
0.54
77
440
105
638
1.74
6.08
2.4
2.1
342.5
380.9
nmol/l
1.26
96
596
19
53
3.65
6.06
2.1
2.5
1.4
1.4
e9/l
0.03
12
30
223
1631
1.51
6.03
2.4
2.0
126.0
179.8
u/l
0.69
214
1541
295
2298
1.45
5.76
2.0
1.8
94.7
97.7
pmol/l
0.63
145
1180
215
1576
1.50
5.71
3.9
2.7
0.1
0.4
e6/l
7.70
165
1153
215
1576
1.50
5.71
3.8
2.7
—
—
—
0
0
250
1892
1.47
5.66
2.1
2.0
—
—
—
0
0
37
158
2.41
5.65
3.1
2.9
—
—
—
0
0
15
39
3.90
5.28
2.1
2.6
14.2
12.9
%
—
10
21
376
3117
1.39
4.95
6.0
5.5
9.7
10.2
umol/l
0.60
355
2938
167
1198
1.50
4.86
3.2
2.3
4.9
8.4
e6/l
3.23
146
1060
83
506
1.71
4.76
3.1
3.3
4.4
4.5
pmol/l
0.94
76
449
49
253
2.00
4.74
1.6
1.3
—
—
—
0
0
13
33
3.99
4.72
1.3
1.6
53.6
44.8
%
—
5
17
124
847
1.55
4.52
3.4
2.6
3.5
4.3
e6/l
0.29
67
423
95
609
1.64
4.51
5.0
3.5
—
—
—
0
0
506
4443
1.38
4.49
5.1
4.0
5866.0
1303.2
e6/l
—
5
57
194
1460
1.43
4.37
2.8
2.4
3569.0
5406.7
umol/l
0.32
176
1277
155
1120
1.48
4.32
3.4
2.4
500.0
528.8
mosm/kgh2o
0.92
137
963
76
465
1.70
4.31
2.9
3.2
1.2
1.2
mmol/l
0.00
67
399
102
673
1.59
4.31
3.0
2.7
6.1
5.8
umol/l
0.09
87
570
93
601
1.62
4.28
1.2
1.2
—
—
—
0
0
138
976
1.50
4.27
3.9
3.1
118.5
259.5
ng/l
0.81
83
614
240
1895
1.38
4.07
2.8
2.4
58.8
55.8
u/l
0.42
223
1746
64
381
1.74
4.02
2.0
2.7
66.9
67.4
g/l
0.18
59
351
226
1772
1.38
3.99
5.2
3.6
0.0
0.0
estimate
1.08
104
656
786
7621
2.93
3.95
23.1
16.3
90.7
90.4
fl
1.23
780
7530
165
1227
1.43
3.94
1.6
1.6
425.4
39734275.5
pmol/l
1.82
140
1052
14
43
3.30
3.92
4.6
3.5
—
—
—
0
0
786
7623
2.91
3.91
23.0
16.2
30.2
30.1
pg
1.07
780
7530
403
3461
1.33
3.89
5.8
4.4
6.2
6.4
mmol/l
1.36
376
3144
786
7624
2.90
3.89
23.2
16.3
4.4
4.5
e12/l
0.79
775
7445
36
180
2.05
3.84
1.7
2.3
1.4
1.4
g/l
0.18
31
157
95
634
1.57
3.84
7.9
5.2
1.0
1.1
mmol/l
0.10
90
586
711
6695
1.56
3.83
15.9
11.7
3.9
3.9
mmol/l
0.59
687
6486
17
60
2.87
3.81
1.2
1.7
50.6
53.6
%
—
8
36
786
7628
2.87
3.81
23.2
16.4
6.4
6.6
e9/l
3.04
774
7442
388
3322
1.33
3.79
4.6
3.3
0.0
0.0
estimate
0.00
101
649
786
7629
2.86
3.78
23.3
16.4
133.4
133.7
g/l
0.31
780
7537
68
419
1.68
3.78
1.2
1.4
—
—
—
0
0
785
7617
2.75
3.74
23.2
16.3
263.7
262.5
e9/l
0.20
776
7450
388
3332
1.32
3.67
6.1
4.4
0.0
0.0
estimate
0.50
104
662
26
117
2.26
3.61
1.6
1.5
—
—
—
0
0
391
3367
1.32
3.61
4.6
3.3
0.0
0.0
estimate
0.80
102
649
23
98
2.39
3.60
1.6
1.6
0.5
0.7
g/l
0.39
17
78
25
111
2.29
3.58
1.6
1.4
85.2
114.1
u/ml
—
5
21
707
6672
1.52
3.51
15.7
11.6
139.5
139.7
mmol/l
0.78
686
6485
196
1533
1.37
3.46
1.9
1.8
0.8
0.9
mg/l
0.28
140
1155
205
1620
1.36
3.38
9.2
6.1
—
—
—
0
0
25
114
2.23
3.38
1.0
1.1
—
—
—
0
0
26
121
2.19
3.35
1.5
4.0
27.4
93.8
mg/l
0.63
20
91
26
121
2.19
3.35
1.5
4.0
25.5
50.2
mg/l
0.44
20
89
17
65
2.65
3.32
1.7
1.2
—
—
—
0
0
108
766
1.47
3.30
2.4
2.0
—
—
—
0
0
26
122
2.17
3.29
1.8
1.4
166.1
220.7
u/ml
0.61
18
74
66
420
1.62
3.27
1.3
1.2
—
—
—
0
0
15
54
2.81
3.27
1.0
1.1
—
—
—
0
0
21
90
2.37
3.27
1.1
1.7
—
—
—
0
0
31
157
2.01
3.23
1.5
1.4
226.1
97.6
e6/l
0.39
25
122
18
72
2.53
3.23
1.2
1.2
—
—
—
0
0
53
324
1.68
3.07
1.7
2.2
—
—
—
0
0
165
1290
1.35
2.89
4.4
3.8
—
—
—
0
0
30
157
1.95
2.88
1.4
1.4
6.3
4.0
e6/l
0.25
24
116
28
144
1.98
2.83
1.5
1.5
—
—
—
0
0
124
929
1.40
2.82
1.7
1.7
1179.3
1182.6
nmol/l
0.01
93
701
195
1570
1.32
2.79
2.9
3.2
—
—
—
0
0
472
4253
1.27
2.75
3.4
3.1
—
—
—
0
0
17
72
2.39
2.74
1.6
1.3
—
—
—
0
0
15
60
2.53
2.71
1.1
1.1
—
—
—
0
0
249
2083
1.28
2.67
2.6
3.1
2.3
2.4
mmol/l
0.64
212
1863
16
68
2.38
2.57
1.3
1.2
—
—
nmol/l
—
0
0
20
94
2.16
2.56
1.5
1.7
—
—
—
0
0
36
209
1.76
2.54
1.2
1.2
—
—
—
0
0
240
2011
1.28
2.52
10.1
6.6
1.2
1.1
inr
0.56
99
651
161
1283
1.32
2.47
1.6
1.4
23.0
21.3
nmol/l
0.36
135
1113
181
1469
1.30
2.43
4.8
3.3
—
—
—
0
0
6
12
5.03
2.40
3.8
3.1
—
—
—
0
0
73
514
1.46
2.35
1.5
1.3
—
—
—
0
0
43
269
1.63
2.34
2.5
2.3
—
—
—
0
0
190
1559
1.29
2.34
1.8
1.7
—
—
—
0
0
15
65
2.33
2.32
1.5
1.7
—
—
—
0
0
230
1934
1.27
2.32
3.8
2.9
—
—
—
0
0
9
28
3.24
2.31
5.1
3.9
—
—
—
0
0
22
113
1.97
2.27
2.7
2.6
2.8
2.6
mmol/l
0.10
14
73
22
113
1.97
2.27
1.0
1.0
—
—
—
0
0
743
7180
1.50
2.25
13.4
10.4
—
—
—
0
0
237
2008
1.26
2.23
3.4
2.9
18.1
25.8
ng/l
1.06
119
1104
112
859
1.35
2.22
5.0
3.4
0.8
0.8
mmol/l
0.12
107
803
86
632
1.40
2.21
1.5
1.4
—
—
—
0
0
6
14
4.31
2.15
1.0
1.0
—
—
—
0
0
6
14
4.31
2.15
1.0
1.0
—
—
—
0
0
6
14
4.31
2.15
1.0
1.0
—
—
—
0
0
19
95
2.02
2.12
1.5
4.3
—
—
—
0
0
8
25
3.22
2.10
1.0
1.0
—
—
—
0
0
621
5863
1.27
2.05
19.8
13.3
13.6
13.5
%
0.46
607
5744
107
826
1.34
2.05
1.3
1.2
—
—
—
0
0
9
32
2.83
2.00
1.8
2.2
0.1
0.2
e9/l
—
9
32
684
6546
1.31
1.96
4.6
4.2
2.8
2.9
mmol/l
0.22
633
6107
25
143
1.77
1.91
1.5
1.3
—
—
—
0
0
14
65
2.17
1.89
1.5
1.8
90.7
90.5
%
0.07
14
65
6
17
3.55
1.84
2.2
3.9
—
—
—
0
0
47
321
1.49
1.81
3.3
2.7
101.1
132.3
ng/l
0.54
39
293
13
60
2.19
1.78
2.1
2.4
32.9
31.8
pg
0.39
13
60
6
18
3.35
1.75
1.3
2.2
—
—
—
0
0
72
537
1.37
1.74
1.2
1.3
30.0
27.5
iu/l
0.25
61
464
5
13
3.86
1.71
1.6
2.1
—
—
—
0
0
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
61
444
1.40
1.70
1.9
2.5
3.9
4.1
e9/l
0.26
51
365
85
654
1.34
1.69
1.2
1.2
83.7
159.9
iu/ml
1.73
34
272
21
119
1.79
1.67
1.5
1.5
—
—
—
0
0
6
19
3.17
1.66
1.0
1.2
—
—
—
0
0
16
83
1.95
1.65
1.9
1.5
—
—
—
0
0
28
174
1.63
1.63
1.4
1.4
440.0
415.2
mg/l
0.12
28
161
5
14
3.59
1.61
1.0
1.0
—
—
—
0
0
658
6305
1.25
1.60
4.3
3.8
5.6
5.7
mmol/l
1.97
605
5835
73
554
1.35
1.59
2.8
3.6
—
—
—
0
0
6
20
3.01
1.58
1.8
1.5
—
—
—
0
0
11
50
2.22
1.57
1.2
1.2
—
—
—
0
0
15
78
1.94
1.55
1.1
1.1
—
—
—
0
0
7
27
2.61
1.51
1.0
2.3
—
—
—
0
0
58
428
1.38
1.51
5.3
3.5
87.1
73.9
ng/l
0.51
53
384
11
51
2.17
1.51
1.5
1.3
—
—
—
0
0
672
6466
1.25
1.50
4.5
3.8
4.8
4.8
mmol/l
0.25
632
6075
17
94
1.83
1.48
1.9
1.9
16.4
16.8
%
—
8
40
670
6448
1.24
1.47
16.7
11.7
39.5
39.7
%
0.39
523
5086
177
1517
1.21
1.46
4.6
3.3
96.5
96.7
%
0.03
172
1462
48
345
1.42
1.46
2.4
2.2
4.0
5.4
ug/l
0.60
41
307
69
527
1.34
1.46
15.1
17.0
1.1
1.1
inr
0.37
14
80
34
228
1.51
1.46
1.2
1.3
17.5
10.3
u/l
0.94
23
190
49
355
1.41
1.43
1.3
1.3
163.8
245.1
miu/ml
1.31
30
178
27
173
1.58
1.41
2.7
2.3
3.8
5.9
umol/l
0.75
18
129
21
126
1.68
1.41
1.1
1.2
—
—
—
0
0
70
540
1.32
1.39
2.6
2.1
12082.4
4224.8
u/l
1.02
28
243
223
1964
1.19
1.38
3.1
2.6
—
—
—
0
0
6
23
2.62
1.37
1.2
1.3
—
—
—
0
0
668
6441
1.23
1.35
4.2
3.8
1.6
1.5
mmol/l
2.45
621
6026
99
805
1.26
1.33
2.2
1.9
29.9
29.4
s
0.41
94
777
63
483
1.33
1.32
1.2
1.2
—
—
—
0
0
15
83
1.82
1.32
2.3
2.2
—
—
—
0
0
18
106
1.71
1.30
2.4
1.9
—
—
—
0
0
25
161
1.57
1.30
15.6
4.1
1.6
1.3
mg/l
0.95
25
145
5
18
2.79
1.28
1.4
2.3
4.8
7.8
%
—
5
18
46
338
1.38
1.26
1.0
1.1
—
—
—
0
0
642
6183
1.20
1.22
4.0
3.4
1.2
1.2
mmol/l
2.05
599
5765
5
19
2.64
1.21
1.4
1.2
—
—
—
0
0
8
38
2.12
1.18
1.1
1.1
—
—
—
0
0
11
57
1.94
1.17
1.5
1.1
—
—
—
0
0
24
158
1.54
1.16
1.5
1.3
3.5
3.6
mmol/l
0.41
24
144
25
167
1.51
1.13
1.6
1.4
22.3
23.1
u/l
0.04
19
136
7
31
2.27
1.10
1.1
1.1
165.1
144.3
iu/ml
—
7
31
47
356
1.34
1.10
15.0
8.7
—
—
—
0
0
10
52
1.93
1.06
1.8
1.3
—
—
—
0
0
20
129
1.56
1.06
1.4
1.2
5.3
3.7
u/ml
—
6
50
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
18
114
1.59
1.03
1.3
1.2
—
—
—
0
0
600
5784
1.15
0.95
5.1
4.7
37.3
38.3
mmol/mol
2.25
561
5413
53
419
1.28
0.94
11.4
3.8
2.0
1.9
mmol/l
0.03
47
330
7
37
1.90
0.94
3.6
7.6
—
—
—
0
0
16
101
1.60
0.94
2.9
2.0
—
—
—
0
0
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
16
103
1.56
0.88
1.8
1.4
—
—
—
0
0
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
20
138
1.46
0.82
1.1
1.1
—
—
—
0
0
6
32
1.88
0.82
1.0
1.1
1601.0
1522.0
miu/ml
—
6
32
30
224
1.35
0.81
2.1
2.0
3.3
4.5
iu/l
0.73
14
88
10
58
1.73
0.80
1.3
10.1
6.3
6.7
mmol/l
—
10
46
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
35
271
1.30
0.75
11.7
3.3
131.8
128.1
g/l
0.72
35
266
25
334
0.74
0.74
1.6
1.4
—
—
—
0
0
5
25
2.01
0.72
1.6
1.2
—
—
—
0
0
55
454
1.23
0.72
5.5
3.1
—
—
—
0
0
7
40
1.76
0.71
1.1
1.9
—
1.6
—
0
5
9
57
1.59
0.71
1.2
1.3
—
—
—
0
0
9
57
1.59
0.71
3.9
2.8
—
—
—
0
0
25
331
0.75
0.71
1.6
1.4
—
—
—
0
0
22
160
1.39
0.71
2.3
1.7
—
—
—
0
0
116
1026
1.15
0.70
2.6
2.5
2.4
2.4
mmol/l
0.84
97
907
9
58
1.56
0.70
1.1
1.0
—
—
—
0
0
19
135
1.42
0.69
1.1
1.1
—
—
—
0
0
140
1257
1.14
0.69
1.7
1.7
—
—
—
0
0
26
340
0.76
0.68
1.7
1.5
—
—
—
0
0
37
294
1.27
0.67
1.7
1.7
—
—
—
0
0
336
3174
1.10
0.67
4.2
3.9
—
—
—
0
0
7
43
1.63
0.67
1.0
1.3
—
—
—
0
0
113
1003
1.15
0.66
1.6
1.4
—
—
—
0
0
219
2026
1.11
0.66
2.4
2.1
—
—
—
0
0
48
397
1.22
0.63
1.1
1.5
271.4
301.4
mu/l
0.30
43
349
5
30
1.67
0.61
1.2
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
25
194
1.30
0.56
6.3
3.5
0.6
0.3
g/l
0.42
14
67
6
38
1.58
0.54
1.0
1.0
—
3.6
—
0
8
11
74
1.49
0.53
24.3
2.2
66.3
61.4
%
0.38
11
74
180
1668
1.10
0.53
3.7
3.1
7.1
7.4
mmol/l
0.36
156
1427
55
472
1.18
0.52
4.4
4.3
1.5
2.6
ug/l
0.91
46
414
6
40
1.50
0.51
1.3
1.0
—
—
—
0
0
156
1439
1.10
0.51
4.9
3.4
1.0
1.0
kg/l
0.47
18
202
9
65
1.39
0.50
1.6
1.4
—
—
—
0
0
9
65
1.39
0.50
1.6
1.4
—
—
—
0
0
9
65
1.39
0.50
1.6
1.4
—
—
—
0
0
9
65
1.39
0.50
1.6
1.4
—
—
—
0
0
6
41
1.47
0.50
1.3
1.0
—
—
—
0
0
35
289
1.22
0.49
1.6
1.7
—
—
—
0
0
15
110
1.37
0.49
1.2
1.2
—
—
—
0
0
34
281
1.22
0.48
2.5
2.6
0.4
0.7
ug/l
3.33
18
167
50
431
1.17
0.46
2.7
2.4
—
—
—
0
0
13
94
1.39
0.46
2.9
1.3
—
—
—
0
0
7
49
1.43
0.46
1.0
1.3
—
—
—
0
0
7
49
1.43
0.46
1.4
1.5
—
—
—
0
0
5
31
1.62
0.43
1.2
2.5
34.8
31.4
umol/l
—
5
31
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
31
259
1.20
0.41
1.3
2.1
—
—
—
0
0
23
186
1.24
0.40
1.2
1.4
0.4
0.4
nmol/l
0.12
15
155
0
19
0.00
0.39
0.0
1.1
—
31.1
—
0
5
11
80
1.38
0.38
2.2
1.8
—
—
—
0
0
35
301
1.17
0.35
5.0
3.6
7.4
7.4
ph
—
8
34
160
1506
1.08
0.35
4.6
4.0
17.8
9.0
mg/mmol
0.84
100
927
29
247
1.18
0.33
2.7
2.1
21.1
20.7
s
0.30
22
216
31
266
1.17
0.33
13.4
9.6
1.2
1.4
%
0.53
31
266
153
1443
1.07
0.32
3.8
3.2
121.9
321.8
mg/l
1.01
94
890
31
267
1.17
0.31
13.9
9.5
0.8
0.7
%
1.05
31
267
26
221
1.18
0.31
14.6
13.2
—
—
—
0
0
12
93
1.29
0.30
23.0
3.3
—
—
—
0
0
7
55
1.28
0.30
1.0
1.0
—
0.4
—
0
8
7
55
1.28
0.30
1.6
2.6
—
—
—
0
0
162
1537
1.07
0.29
2.6
2.0
—
—
—
0
0
54
488
1.11
0.29
10.1
9.4
1.1
1.1
mmol/l
0.01
42
388
31
271
1.15
0.27
3.9
8.4
—
—
—
0
0
5
38
1.32
0.23
2.2
2.8
67.2
110.1
nmol/l
—
5
38
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
5
40
1.25
0.22
2.2
1.8
13.7
24.6
ug/l
—
5
40
5
40
1.25
0.22
5.0
2.9
—
—
—
0
0
5
42
1.19
0.21
1.4
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
18
209
0.86
0.21
9.2
7.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
50
1.20
0.19
3.0
3.0
—
—
—
0
0
6
53
1.13
0.18
2.2
1.5
1.5
1.5
nmol/l
—
6
48
18
156
1.16
0.18
1.1
1.0
3.4
1.5
u/ml
—
5
33
7
58
1.21
0.18
2.4
1.9
105.4
106.5
mmol/l
—
7
58
7
58
1.21
0.18
2.4
1.9
3.9
3.9
mmol/l
—
7
58
7
58
1.21
0.18
1.9
1.7
0.8
1.0
g/l
—
7
58
7
58
1.21
0.18
2.4
1.9
—
—
—
0
0
83
875
0.94
0.17
1.3
1.3
—
—
—
0
0
28
309
0.90
0.17
1.1
1.1
—
—
—
0
0
5
69
0.72
0.17
1.2
1.4
33.9
35.8
nmol/l
—
5
60
11
93
1.19
0.14
1.0
1.3
—
—
—
0
0
12
103
1.17
0.13
1.9
2.6
—
—
—
0
0
33
306
1.08
0.13
1.4
1.2
—
—
—
0
0
213
2176
0.97
0.12
1.6
1.6
—
—
—
0
0
53
558
0.95
0.12
1.5
1.8
—
—
—
0
0
11
126
0.87
0.11
2.8
3.7
19.7
24.4
mg/l
—
5
78
53
505
1.05
0.10
1.9
3.9
40.4
7.8
ug/l
0.44
40
394
5
44
1.14
0.10
1.0
2.0
—
—
—
0
0
5
44
1.14
0.10
2.4
2.2
—
—
—
0
0
35
371
0.94
0.10
1.2
1.6
—
—
—
0
0
53
554
0.95
0.09
1.2
1.4
—
—
—
0
0
14
126
1.11
0.09
4.0
3.5
—
—
—
0
0
17
156
1.09
0.08
1.8
1.9
—
—
—
0
0
33
347
0.95
0.07
1.2
1.6
—
—
—
0
0
28
296
0.94
0.07
1.3
1.6
—
—
—
0
0
22
234
0.94
0.06
1.6
1.4
60.3
198.2
pmol/l
1.24
22
229
23
217
1.06
0.06
1.4
1.2
—
—
—
0
0
36
375
0.96
0.06
1.2
1.6
—
—
—
0
0
20
188
1.07
0.05
1.4
1.4
338.5
307.6
ug/g
—
10
106
36
374
0.96
0.05
1.2
1.6
—
—
—
0
0
94
924
1.02
0.04
1.6
1.9
—
—
—
0
0
18
170
1.06
0.04
5.7
5.3
—
—
—
0
0
17
161
1.06
0.03
1.1
1.0
7.4
5.4
u/ml
0.20
11
82
261
2596
1.01
0.02
2.6
2.4
—
—
—
0
0
36
369
0.97
0.02
1.2
1.6
—
—
—
0
0
22
212
1.04
0.02
1.1
1.1
—
—
—
0
0
28
288
0.97
0.02
3.1
2.7
—
—
—
0
0
16
153
1.05
0.01
1.1
1.0
1.2
1.3
u/ml
—
10
59
17
163
1.04
0.01
1.2
1.8
—
—
—
0
0
22
227
0.97
0.01
6.7
3.9
—
—
—
0
0
12
114
1.05
0.00
1.6
2.5
60.9
133.1
ug/min
—
6
75
19
185
1.03
0.00
1.2
1.1
1.9
2.1
u/ml
0.05
11
63
14
139
1.01
0.00
1.1
1.0
11.3
3.6
u/ml
—
7
48
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
1.7
—
0
7
0
7
0.00
0.00
0.0
13.0
—
—
—
0
0
7
73
0.96
0.00
1.6
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
16
160
1.00
0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
7
71
0.99
0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
16
160
1.00
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
14
140
1.00
0.00
1.4
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.3
—
—
—
0
0
14
140
1.00
0.00
1.6
2.1
—
—
—
0
0
5
57
0.88
0.00
1.6
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PERIORALDERM and mortality.

Females

Parameter HR [95% CI] p-value
L12_PERIORALDERM 0.904 [0.74, 1.1] 0.316
Birth year 0.996 [0.99, 1.0] 0.35

During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 2529 females with L12_PERIORALDERM died.

Males

Parameter HR [95% CI] p-value
L12_PERIORALDERM 1.434 [1.09, 1.89] 0.011
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 585 males with L12_PERIORALDERM died.

Mortality risk

Mortality risk for people of age

years, who have L12_PERIORALDERM.

N-year risk Females Males
1 0.089% 0.262%
5 0.583% 1.442%
10 1.383% 3.6%
15 2.476% 7.047%
20 4.8% 12.19%

Relationships between endpoints

↥

Index endpoint: L12_PERIORALDERM – Perioral dermatitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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