rosacea: a chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
845 |
4. Check minimum number of eventsNone |
845 |
5. Include endpointsNone |
845 |
6. Filter based on genotype QC (FinnGen only) |
821 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L71
- Name in latin
- Dermatitis perioralis
Similar endpoints
↥List of similar endpoints to
Perioral dermatitis
based on the number of shared cases.
Similar with more cases:
- Rosacea
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4435 | 3704 | 720 |
| Only index persons | 4253 | 3606 | 647 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.02 |
| Only index persons | 0.12 | 0.13 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 40.59 | 40.25 | 42.27 |
| Only index persons | 40.98 | 40.43 | 44.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 821 | 737 | 84 |
| Unadjusted period prevalence (%) | 0.24 | 0.26 | 0.04 |
| Median age at first event (years) | 46.15 | 45.15 | 54.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 845
- Matched controls
- 8450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D06BX01
ATC
metronidazole; topical
24.5
307.7
529
540
L71.0
ICD-10 Finland
Perioral dermatitis
4503599627370496.0
307.7
843
69
J01AA04
ATC
lymecycline; systemic
10.5
260.9
421
732
L71.8
ICD-10 Finland
Other rosacea
64.4
165.8
92
16
J01AA07
ATC
tetracycline; systemic
6.1
139.6
349
880
L71.9
ICD-10 Finland
Rosacea, unspecified
22.8
132.0
99
49
E0000UV, ,
ATC
3.8
77.1
539
2676
D10AX03
ATC
azelaic acid; topical
4.5
64.6
186
497
L70.0
ICD-10 Finland
Acne vulgaris
9.9
56.4
67
73
L71
ICD-10 Finland
Rosacea
9.0
53.8
69
83
D10BA01
ATC
isotretinoin; oral
4.5
48.8
134
341
XQ802
NOMESCO Finland
Epicutan test
5.6
48.6
98
192
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
47.5
124
303
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.7
44.1
162
507
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
42.2
256
1084
XQ800
NOMESCO Finland
Prick test
3.6
35.0
128
397
E000001, ,
ATC
2.5
29.3
246
1198
D07AC01
ATC
betamethasone; topical
2.3
28.3
348
1995
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
26.5
225
1094
L04AX03
ATC
methotrexate; systemic
3.1
25.8
122
440
D07AD01
ATC
clobetasol; topical
2.6
25.4
182
816
D07AC13
ATC
mometasone; topical
2.2
24.2
294
1654
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.6
23.4
154
661
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
23.1
306
1775
J02AC01
ATC
fluconazole; systemic
2.0
22.0
459
3128
L04AX01
ATC
azathioprine; systemic
4.3
21.5
58
144
L20.0
ICD-10 Finland
Besnier prurigo
2.7
20.9
122
491
H02AB06
ATC
prednisolone; systemic
1.9
19.8
418
2826
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
19.7
379
2482
D02AE01
ATC
carbamide; topical
3.2
18.9
79
264
D07AB08
ATC
desonide; topical
2.5
18.6
125
539
D02AX
ATC
Other emollients and protectives
4.2
18.2
49
121
R06AX27
ATC
desloratadine; oral
1.9
17.6
326
2086
D07XC01
ATC
betamethasone; topical
2.6
17.3
112
473
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.4
16.9
63
196
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.6
16.6
57
168
UJF32
NOMESCO Finland
Coloscopy
2.0
15.6
202
1137
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
15.4
240
1441
L43.8
ICD-10 Finland
Other lichen planus
6.4
15.1
25
40
R06AE07
ATC
cetirizine; oral
1.8
15.0
439
3190
E0001A1, ,
ATC
4.4
14.7
37
87
D10AF01
ATC
clindamycin; topical
3.0
14.7
68
241
XQ848
NOMESCO Finland
Dermatological photography
4.9
14.6
32
67
L57.0
ICD-10 Finland
Actinic keratosis
2.9
14.6
73
270
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
14.5
233
1407
L70
ICD-10 Finland
Acne
4.4
14.2
36
85
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
14.0
107
487
R06AE09
ATC
levocetirizine; oral
2.0
13.9
167
911
S01AD03
ATC
aciclovir; ophthalmic
3.7
13.3
42
117
D11AH01
ATC
tacrolimus; topical
6.0
13.1
23
39
L04AA06
ATC
mycophenolic acid; systemic
6.0
13.1
23
39
P01BA02
ATC
hydroxychloroquine; oral
2.5
13.0
89
385
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
5.7
12.9
24
43
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
5.0
12.9
28
58
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.4
12.9
46
139
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.3
12.8
33
79
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.6
12.6
24
44
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
6.1
12.6
22
37
S29
ICPC
Skin symptom/complaint other
1.9
11.6
168
974
L71.1
ICD-10 Finland
Rhinophyma
+∞
11.5
11
*
L70.1
ICD-10 Finland
Acne conglobata
121.6
11.5
12
*
J02AC02
ATC
itraconazole; systemic
1.9
11.3
166
965
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
5.8
11.0
20
35
L30.8
ICD-10 Finland
Other specified dermatitis
3.7
10.9
34
94
R01AD08
ATC
fluticasone; nasal
1.7
10.7
274
1871
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.2
10.7
42
135
E000006, ,
ATC
2.4
10.7
73
316
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
10.6
209
1330
L04AD01
ATC
ciclosporin; systemic
4.9
10.5
23
48
L50.3
ICD-10 Finland
Dermatographic urticaria
4.2
10.5
28
69
R96
ICPC
Asthma
2.2
10.4
88
417
J01AA02
ATC
doxycycline; systemic
1.7
10.3
631
5344
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
5.0
10.3
22
45
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
10.2
254
1720
D07AA02
ATC
hydrocortisone; topical
1.9
10.0
140
799
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.0
10.0
125
687
S18
ICPC
Laceration/cut
1.6
9.9
343
2518
L01BA01
ATC
methotrexate; systemic
3.3
9.8
37
116
TQW80
NOMESCO Finland
Local dermatologic skincare
4.3
9.7
25
60
B07.9
ICD-10 Finland
Verruca simplex
3.1
9.6
39
128
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.6
9.5
56
226
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
2.4
9.5
68
301
L30.3
ICD-10 Finland
Infective dermatitis
3.2
9.4
37
119
D11AH02
ATC
pimecrolimus; topical
10.8
9.3
17
16
S21
ICPC
Skin texture symptom/complaint
1.9
9.0
119
666
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.3
9.0
67
301
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.3
9.0
71
328
TQW99
NOMESCO Finland
Other minor procedure on skin
2.9
8.9
40
140
R03BA02
ATC
budesonide; inhalant
1.7
8.8
167
1044
R69
ICD-10 Finland
Unknown and unspecified causes of morbidity
4.5
8.7
21
48
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.4
8.6
58
249
WZA10
NOMESCO Finland
Extensive medical or dental certificate
4.6
8.6
20
44
R06AX22
ATC
ebastine; oral
1.7
8.6
169
1067
L30.0
ICD-10 Finland
Nummular dermatitis
3.4
8.4
30
91
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
4.5
8.4
20
45
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
8.0
8.4
18
23
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
8.2
110
618
N05CF02
ATC
zolpidem; oral
1.7
8.1
154
962
K30
ICD-10 Finland
Functional dyspepsia
1.9
8.1
104
576
L70.9
ICD-10 Finland
Acne, unspecified
8.2
8.1
17
21
R05
ICD-10 Finland
Cough
1.7
8.1
181
1183
A02BC02
ATC
pantoprazole; systemic
1.5
8.1
519
4307
ZXC50
NOMESCO Finland
Cryotherapy
3.9
8.0
23
60
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.7
8.0
155
974
A07EC01
ATC
sulfasalazine; oral, rectal
2.2
8.0
71
344
H02AB07
ATC
prednisone; oral
1.9
7.9
109
618
L20
ICD-10 Finland
Atopic dermatitis
2.7
7.8
41
156
J45.1
ICD-10 Finland
Nonallergic asthma
2.3
7.8
61
281
L21.0
ICD-10 Finland
Seborrhoea capitis
7.5
7.7
17
23
D07XB05
ATC
dexamethasone; topical
3.1
7.7
31
102
A02BC05
ATC
esomeprazole; systemic
1.5
7.6
314
2365
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.6
7.5
43
171
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.2
7.5
29
93
J01DB01
ATC
cefalexin; oral
1.7
7.5
692
6176
L04AA01
ATC
[U] ciclosporin
6.5
7.4
18
28
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.0
7.4
85
453
R01AD58
ATC
fluticasone, combinations; nasal
1.6
7.3
242
1736
SPAT1153
SPAT
Removal of sutures
1.6
7.2
221
1554
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.2
291
2174
SPAT1263
SPAT
Sampling
1.5
7.2
345
2671
G03HB01
ATC
cyproterone and estrogen; oral
1.8
7.2
123
745
L21
ICD-10 Finland
Seborrhoeic dermatitis
3.7
7.1
22
61
D06BB03
ATC
aciclovir; topical
2.4
7.1
49
214
A07EC02
ATC
mesalazine; oral, rectal
2.4
7.0
48
208
L82
ICD-10 Finland
Seborrhoeic keratosis
1.7
7.0
131
813
K07.60
ICD-10 Finland
Snapping jaw
2.1
7.0
68
341
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
4.4
7.0
17
39
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.1
6.9
69
350
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.6
6.9
40
161
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
6.8
240
1739
L04AB04
ATC
adalimumab; parenteral
3.1
6.8
28
93
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.8
199
1383
C10AC01
ATC
colestyramine; oral
3.1
6.8
27
88
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.5
6.8
397
3189
E000007, ,
ATC
2.2
6.7
58
278
UDC00
NOMESCO Finland
Ear microscopy
2.1
6.7
61
299
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.6
262
1945
L01
ICPC
Neck symptom/complaint
1.7
6.6
144
932
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
6.6
170
1148
L88
ICPC
Rheumatoid/seropositive arthritis
2.6
6.5
36
141
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
6.5
82
452
H02AB04
ATC
methylprednisolone; systemic
1.7
6.5
111
673
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.6
6.4
37
148
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.4
477
3991
R01AD11
ATC
triamcinolone; nasal
1.9
6.3
79
435
Z3231
NOMESCO Finland
Registered nurse
1.5
6.3
200
1416
D05AX52
ATC
calcipotriol, combinations; topical
2.4
6.2
41
175
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.2
152
1012
R03AC02
ATC
salbutamol; inhalant
1.4
6.2
473
3967
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
6.2
150
997
E000002, ,
ATC
1.7
6.1
105
637
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
6.0
93
546
J01DA09
ATC
[U] cefadroxil
1.5
6.0
215
1557
L72.1
ICD-10 Finland
Trichilemmal cyst
2.4
6.0
41
178
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
499
3357
2.19
26.63
7.9
5.1
55.97
56.52
%
0.49
475
3133
502
3398
2.18
26.20
8.2
5.3
29.59
29.42
%
0.13
479
3176
546
3998
2.03
20.92
10.8
8.1
3.65
3.95
e9/l
2.05
497
3506
653
5169
2.16
19.41
5.7
3.8
10.64
10.54
mm/h
0.06
604
4808
632
5064
1.98
16.43
8.6
6.5
73.06
74.71
u/l
0.57
602
4740
79
295
2.85
15.51
1.3
1.3
0.97
0.67
u/ml
—
9
21
412
2963
1.76
14.39
2.7
2.2
82.15
76.01
nmol/l
4.53
380
2717
405
2933
1.73
13.53
7.5
6.0
1.22
1.22
mmol/l
0.20
343
2467
367
2604
1.72
13.06
6.9
5.4
1.23
1.22
mmol/l
0.96
338
2377
55
186
3.09
12.86
1.4
1.2
23.73
15.58
u/ml
—
10
34
54
182
3.10
12.70
1.4
1.2
1.26
3.26
u/ml
—
5
19
61
224
2.86
12.35
2.5
2.0
—
—
—
0
0
209
1316
1.78
11.00
1.3
1.3
9.14
9.85
u/ml
0.07
94
530
55
205
2.80
10.84
1.6
1.5
0.08
0.41
iu/ml
0.43
11
27
246
1629
1.72
10.82
1.8
1.4
2.27
2.15
g/l
0.61
167
1007
788
7158
2.50
10.60
15.3
10.8
15.90
19.80
mg/l
4.34
619
5465
103
522
2.11
10.33
1.7
1.2
196.01
222.92
u/ml
0.13
97
482
157
924
1.86
10.25
2.5
2.1
14.13
13.98
umol/l
0.09
145
857
134
756
1.92
9.95
2.6
2.2
23.57
23.20
%
0.12
122
644
143
830
1.87
9.72
2.5
2.1
2.40
2.43
g/l
0.31
129
760
273
1905
1.64
9.66
1.4
1.3
1.14
1.72
u/ml
0.63
77
501
167
1025
1.78
9.45
2.9
2.3
116.87
96.86
ug/g
0.36
134
796
32
95
3.46
9.25
1.8
1.3
—
—
—
0
0
100
532
2.00
8.78
4.9
4.4
238.46
250.28
u/l
0.22
95
504
44
164
2.78
8.70
1.3
1.2
28.37
42.07
u/ml
—
7
18
19
40
4.84
8.62
2.5
2.7
—
—
—
0
0
753
6828
1.94
8.42
5.8
5.0
1.70
1.96
mu/l
0.84
695
6389
675
5954
1.66
8.01
4.9
4.3
14.47
14.47
pmol/l
0.01
608
5513
115
662
1.85
7.97
2.3
2.0
336.84
382.95
nmol/l
1.80
105
618
330
2499
1.53
7.85
5.5
4.4
36.47
36.46
g/l
0.01
311
2342
202
1377
1.61
7.59
1.4
1.3
22.47
27.16
iu/ml
0.45
71
463
452
3672
1.50
7.57
3.4
2.7
78.68
75.61
ug/l
0.23
420
3440
237
1701
1.55
7.07
1.6
1.6
1.27
1.34
mmol/l
0.78
201
1465
801
7512
2.27
6.83
13.2
8.8
24.97
24.01
u/l
0.80
785
7264
249
1819
1.52
6.81
3.9
2.9
16.25
99.62
e6/l
1.40
194
1369
314
2425
1.47
6.48
2.0
1.8
96.21
97.26
pmol/l
0.17
154
1250
58
284
2.12
6.38
1.5
1.7
—
—
—
0
0
235
1717
1.51
6.36
2.3
2.1
124.75
178.40
u/l
0.74
226
1622
226
1638
1.52
6.36
2.5
2.0
2.67
2.78
mg/l
0.43
193
1394
35
138
2.60
6.27
4.5
4.1
3.59
4.26
e9/l
1.17
35
138
36
144
2.57
6.26
4.8
4.3
53.11
57.91
%
1.21
36
144
72
386
1.95
6.19
1.9
1.6
—
—
—
0
0
34
133
2.62
6.19
1.2
1.3
—
—
—
0
0
25
83
3.07
6.11
1.0
1.1
—
—
—
0
0
226
1653
1.50
6.05
3.9
2.7
0.08
0.37
e6/l
7.78
175
1220
724
6628
1.64
6.00
13.4
9.5
87.84
88.41
ml/min/173m2
0.31
616
5319
254
1905
1.48
6.00
1.7
1.6
—
—
—
0
0
100
601
1.75
5.99
2.4
2.8
—
—
—
0
0
396
3271
1.40
5.35
6.0
5.4
9.69
10.19
umol/l
0.69
373
3085
176
1259
1.50
5.16
3.2
2.3
5.60
8.34
e6/l
2.04
158
1127
105
669
1.65
5.08
8.4
5.0
1.04
1.05
mmol/l
0.12
100
619
28
111
2.57
5.00
1.8
1.4
100.86
112.86
u/ml
—
7
21
205
1521
1.46
5.00
3.1
2.3
3409.76
5620.70
umol/l
0.43
185
1341
131
887
1.56
4.94
3.3
2.7
3.61
4.21
e6/l
0.20
71
450
23
83
2.82
4.91
1.4
1.1
—
—
—
0
0
138
949
1.54
4.85
3.3
2.5
1.10
1.02
e6/l
0.04
79
507
12
21
5.78
4.76
1.3
1.1
94.42
102.86
%
0.52
12
21
15
34
4.47
4.76
4.2
3.1
818.67
706.91
u/ml
0.13
15
34
754
7056
1.64
4.74
15.7
11.6
3.90
3.91
mmol/l
0.57
730
6834
537
4722
1.38
4.67
5.0
4.0
5866.00
1240.67
e6/l
—
5
60
87
540
1.68
4.66
3.0
3.4
4.39
4.55
pmol/l
1.02
79
479
78
473
1.72
4.55
1.1
1.0
—
—
—
0
0
254
1989
1.40
4.54
2.9
2.3
58.61
60.67
u/l
0.20
236
1836
624
5638
1.41
4.52
3.9
3.5
—
—
—
0
0
30
130
2.36
4.48
2.1
1.3
169.50
228.58
u/ml
0.76
20
80
106
699
1.59
4.47
3.7
2.5
6.04
5.78
umol/l
0.08
90
588
428
3648
1.35
4.46
5.7
4.4
6.20
6.39
mmol/l
1.28
401
3316
750
7036
1.59
4.34
15.5
11.5
139.55
139.66
mmol/l
0.68
729
6836
831
8051
2.94
4.26
23.4
16.2
39.68
39.83
%
0.35
802
7639
67
397
1.75
4.25
2.1
2.7
66.90
67.36
g/l
0.16
62
365
239
1871
1.39
4.24
5.2
3.6
0.00
0.00
estimate
1.08
107
695
31
140
2.26
4.23
2.1
1.3
—
—
—
0
0
37
181
2.09
4.16
1.6
2.0
—
—
—
0
0
299
2433
1.35
4.14
11.7
9.8
1.14
1.13
inr
0.09
117
779
174
1300
1.43
4.02
1.6
1.6
421.61
43345756.86
pmol/l
2.06
148
1112
412
3529
1.33
3.99
4.6
3.3
0.00
0.00
estimate
-0.00
108
728
831
8065
2.83
3.97
23.1
16.2
4.44
4.47
e12/l
0.77
820
7877
412
3533
1.32
3.94
6.1
4.4
0.00
0.00
estimate
0.50
107
700
831
8070
2.80
3.87
23.1
16.3
133.33
133.61
g/l
0.29
825
7971
415
3571
1.32
3.84
4.6
3.3
0.00
0.01
estimate
0.80
105
688
29
133
2.22
3.83
1.1
1.2
—
—
—
0
0
830
8058
2.69
3.82
23.1
16.2
263.63
262.48
e9/l
0.21
821
7882
6
5
12.07
3.77
5.0
7.6
—
—
—
0
0
11
24
4.63
3.75
2.5
1.4
9.17
7.50
ug/l
0.96
11
24
77
493
1.62
3.69
2.9
3.1
1.23
1.23
mmol/l
0.09
68
423
86
566
1.58
3.68
2.7
2.2
46.10
34.87
u/l
0.36
77
466
33
163
2.07
3.64
1.5
1.5
209.33
126.66
e6/l
0.24
27
127
28
131
2.18
3.55
1.6
3.8
26.57
87.51
mg/l
0.65
21
101
28
131
2.18
3.55
1.5
3.8
28.68
47.12
mg/l
0.34
21
99
141
1040
1.43
3.48
3.9
3.1
117.34
275.36
ng/l
0.96
84
649
37
195
1.94
3.44
1.7
2.3
1.39
1.38
g/l
0.01
32
171
10
22
4.59
3.43
1.3
1.5
—
—
—
0
0
168
1284
1.38
3.38
2.7
2.7
884.04
829.18
ng/l
0.09
134
1061
107
753
1.48
3.37
2.5
1.7
—
—
—
0
0
206
1632
1.35
3.30
2.1
1.7
0.82
0.90
mg/l
0.34
146
1225
32
163
2.00
3.28
1.4
1.4
6.08
4.45
e6/l
0.17
25
121
17
66
2.61
3.23
1.2
1.7
50.63
51.62
%
—
8
39
265
2184
1.31
3.22
2.6
3.1
2.34
2.35
mmol/l
0.67
226
1964
132
976
1.42
3.21
1.7
1.7
1172.23
1191.29
nmol/l
0.08
98
736
539
4872
1.29
3.18
3.4
2.8
34.40
37.87
u/l
0.71
501
4624
38
210
1.85
3.09
1.2
1.2
—
—
—
0
0
38
211
1.84
3.05
1.2
1.2
—
—
—
0
0
40
226
1.81
3.04
1.4
1.3
—
—
—
0
0
238
1949
1.31
3.00
1.5
1.5
—
—
—
0
0
5
5
10.05
2.98
1.0
1.6
—
—
—
0
0
29
148
1.99
2.98
1.6
1.5
—
—
—
0
0
9
22
4.12
2.88
1.2
1.3
—
—
—
0
0
323
2763
1.27
2.88
4.7
3.3
—
—
—
0
0
172
1358
1.33
2.79
1.6
1.4
22.78
21.33
nmol/l
0.33
144
1181
9
23
3.94
2.78
1.2
1.3
—
—
—
0
0
41
241
1.74
2.75
1.1
1.1
1.34
6.10
u/ml
—
8
41
5
6
8.37
2.75
4.2
3.0
—
—
—
0
0
13
48
2.74
2.72
1.8
1.2
—
—
—
0
0
41
242
1.73
2.72
1.5
1.4
—
—
—
0
0
23
113
2.06
2.63
1.5
1.8
—
—
—
0
0
11
38
2.92
2.42
1.7
1.3
—
—
—
0
0
14
58
2.44
2.38
1.1
1.3
—
—
—
0
0
266
2271
1.25
2.32
4.1
2.9
29.74
28.18
u/l
0.55
253
2160
249
2110
1.26
2.32
3.4
2.9
18.21
27.51
ng/l
1.33
125
1154
17
78
2.20
2.32
1.2
1.3
—
—
—
0
0
17
78
2.20
2.32
1.2
1.3
—
—
—
0
0
14
59
2.40
2.30
1.1
1.3
—
—
—
0
0
8
23
3.50
2.27
1.1
1.2
—
—
—
0
0
17
79
2.18
2.26
1.2
1.3
—
—
—
0
0
17
79
2.18
2.26
1.2
1.3
—
—
—
0
0
13
54
2.43
2.20
1.0
1.0
—
—
—
0
0
111
853
1.35
2.17
2.4
1.9
29.58
29.47
s
0.07
105
824
124
969
1.33
2.16
2.5
1.9
—
—
—
0
0
7
19
3.71
2.15
1.1
1.3
—
—
—
0
0
7
19
3.71
2.15
1.1
1.3
—
—
—
0
0
6
14
4.31
2.15
1.0
1.0
—
—
—
0
0
723
6911
1.32
2.14
4.6
4.2
2.83
2.86
mmol/l
0.43
670
6469
699
6652
1.29
2.14
4.3
3.8
5.57
5.71
mmol/l
2.51
641
6158
17
81
2.12
2.13
1.2
1.3
—
—
—
0
0
17
81
2.12
2.13
1.2
1.3
—
—
—
0
0
674
6392
1.27
2.07
19.5
13.1
14.31
14.46
%
0.37
660
6275
6
15
4.02
2.04
3.8
6.1
—
—
—
0
0
30
178
1.71
2.01
1.4
1.4
433.53
429.35
mg/l
0.02
30
165
29
171
1.72
1.99
15.8
3.7
1.55
1.30
mg/l
0.81
29
154
6
16
3.77
1.93
2.2
2.3
72.85
49.60
ug/l
—
6
16
91
694
1.35
1.89
1.2
1.2
81.79
157.82
iu/ml
1.80
35
288
20
107
1.89
1.87
1.2
1.2
—
—
—
0
0
63
453
1.42
1.85
5.8
3.4
87.00
73.15
ng/l
0.59
58
405
5
12
4.18
1.82
1.4
2.5
—
—
—
0
0
108
856
1.30
1.73
1.7
1.8
—
—
—
0
0
25
148
1.71
1.72
1.6
1.4
—
—
—
0
0
5
13
3.86
1.71
1.0
1.0
—
—
—
0
0
14
68
2.08
1.71
1.5
1.9
90.68
90.33
%
0.14
14
68
711
6827
1.26
1.70
4.5
3.8
4.78
4.82
mmol/l
0.46
668
6426
36
236
1.55
1.68
1.2
1.3
16.56
10.29
u/l
0.87
25
194
21
119
1.78
1.67
1.0
1.1
—
—
—
0
0
23
136
1.71
1.60
1.3
1.5
—
—
—
0
0
187
1596
1.22
1.60
4.9
3.3
96.48
96.85
%
0.08
182
1537
33
215
1.56
1.59
1.8
1.8
—
—
—
0
0
75
572
1.34
1.58
1.2
1.3
30.30
27.98
iu/l
0.23
63
495
17
92
1.87
1.57
1.3
1.5
—
—
—
0
0
162
1365
1.23
1.57
2.5
2.1
—
—
—
0
0
13
64
2.05
1.54
2.1
2.4
32.92
31.97
pg
0.33
13
64
76
585
1.33
1.52
2.6
2.2
11869.69
5326.24
u/l
0.81
29
267
26
162
1.62
1.51
1.5
1.3
3.46
3.62
mmol/l
0.53
26
148
706
6799
1.23
1.47
4.2
3.8
1.60
1.55
mmol/l
2.51
656
6377
7
28
2.51
1.45
1.3
1.4
—
—
—
0
0
12
59
2.05
1.44
1.4
1.2
—
—
—
0
0
12
59
2.05
1.44
1.4
1.2
—
—
—
0
0
47
338
1.41
1.43
3.3
2.7
101.13
130.09
ng/l
0.49
39
306
51
373
1.39
1.41
1.3
1.3
163.21
239.77
miu/ml
1.27
31
190
46
331
1.41
1.40
1.4
1.5
—
—
—
0
0
35
239
1.48
1.39
1.9
1.8
—
—
—
0
0
12
60
2.01
1.38
1.4
1.2
—
—
—
0
0
12
60
2.01
1.38
1.4
1.1
—
—
—
0
0
12
60
2.01
1.38
1.4
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
127
1.67
1.37
3.2
3.8
0.30
0.39
u/ml
—
8
72
680
6538
1.21
1.36
4.0
3.4
1.15
1.23
mmol/l
2.59
632
6104
28
183
1.55
1.36
3.1
2.3
3.76
5.85
umol/l
0.81
19
136
49
359
1.39
1.35
2.3
2.2
3.96
5.48
ug/l
0.68
42
318
638
6102
1.19
1.34
5.1
4.7
37.24
38.28
mmol/mol
2.64
594
5711
9
42
2.15
1.34
1.9
1.1
—
—
—
0
0
67
517
1.32
1.34
1.4
1.4
—
—
—
0
0
17
98
1.75
1.31
1.4
1.4
—
—
—
0
0
17
98
1.75
1.31
1.4
1.4
—
—
—
0
0
17
98
1.75
1.31
1.9
1.9
16.43
16.79
%
—
8
43
21
129
1.64
1.31
1.4
1.5
—
—
—
0
0
6
24
2.51
1.30
1.2
2.8
—
—
—
0
0
73
573
1.30
1.30
13.6
6.7
104.25
104.37
mmol/l
0.09
73
573
9
44
2.06
1.27
8.6
3.3
—
—
—
0
0
10
49
2.05
1.22
1.2
1.4
—
—
—
0
0
10
49
2.05
1.22
1.2
1.4
—
—
—
0
0
10
49
2.05
1.22
1.2
1.4
—
—
—
0
0
5
20
2.51
1.15
1.2
1.9
—
—
—
0
0
5
20
2.51
1.15
1.2
1.9
—
—
—
0
0
31
216
1.45
1.15
12.8
2.6
0.75
0.67
%
0.56
31
216
31
216
1.45
1.15
1.2
1.1
—
—
—
0
0
173
1514
1.18
1.14
2.6
2.2
—
—
—
0
0
7
30
2.34
1.12
1.1
1.5
—
—
—
0
0
7
30
2.34
1.12
1.0
1.1
—
—
—
0
0
7
30
2.34
1.12
1.1
1.5
—
—
—
0
0
8
41
1.96
1.09
1.3
2.1
—
—
—
0
0
26
177
1.48
1.09
1.6
1.3
21.48
23.09
u/l
0.09
20
143
7
32
2.20
1.08
1.0
1.1
1449.43
1459.56
miu/ml
—
7
32
7
32
2.20
1.08
1.0
1.1
—
—
—
0
0
7
32
2.20
1.08
1.1
1.1
165.13
145.44
iu/ml
—
7
32
15
90
1.68
1.04
2.3
2.2
—
—
—
0
0
56
439
1.30
1.04
11.6
3.7
1.92
1.91
mmol/l
0.00
50
358
9
48
1.88
1.00
1.1
1.1
—
—
—
0
0
11
61
1.81
0.98
1.3
1.5
—
—
—
0
0
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
125
1083
1.18
0.94
2.6
2.5
2.42
2.43
mmol/l
0.67
104
956
6
27
2.23
0.93
1.0
1.0
—
—
—
0
0
195
1752
1.15
0.92
3.8
3.1
7.15
7.37
mmol/l
0.25
167
1511
11
63
1.76
0.90
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
3.0
2.8
50116.67
36265.69
ug/l
—
6
29
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
12
71
1.70
0.89
1.0
1.1
—
—
—
0
0
20
136
1.48
0.87
1.4
1.2
5.33
3.60
u/ml
—
6
52
20
136
1.48
0.87
1.4
1.2
4.43
3.00
u/ml
—
7
46
8
44
1.83
0.86
1.3
1.2
—
—
—
0
0
60
492
1.24
0.81
2.1
2.3
71.53
71.91
ml/min/173m2
0.03
32
188
6
33
1.82
0.79
2.2
2.2
32.50
31.12
umol/l
—
6
33
37
287
1.30
0.78
11.1
3.3
133.00
127.77
g/l
1.17
37
282
6
34
1.77
0.76
1.3
1.1
124.83
108.50
%
—
6
28
5
25
2.01
0.72
1.2
1.4
—
—
—
0
0
10
60
1.67
0.72
1.3
9.7
6.30
6.70
mmol/l
—
10
48
169
1533
1.13
0.70
5.0
3.5
1.01
1.02
kg/l
0.50
19
214
7
41
1.71
0.70
1.3
1.5
—
—
—
0
0
45
369
1.23
0.64
2.1
1.7
5.41
4.37
mg/l
0.24
32
258
72
834
0.85
0.64
1.6
1.5
—
—
—
0
0
40
488
0.81
0.62
1.6
1.5
—
—
—
0
0
12
80
1.51
0.60
1.3
1.5
—
—
—
0
0
8
52
1.54
0.59
1.3
1.5
—
—
—
0
0
18
131
1.38
0.59
1.1
1.1
—
—
—
0
0
85
746
1.16
0.59
4.4
3.8
35.26
32.77
%
1.22
62
521
353
3356
1.09
0.59
2.6
2.5
—
—
—
0
0
171
1571
1.11
0.58
4.7
3.8
18.04
9.00
mg/mmol
0.93
106
966
37
450
0.81
0.56
1.5
1.4
—
—
—
0
0
37
302
1.24
0.56
6.8
3.2
0.83
1.69
mmol/l
0.75
26
212
8
55
1.46
0.56
1.5
1.5
12.09
10.14
umol/l
—
8
50
37
449
0.82
0.55
1.5
1.4
—
—
—
0
0
37
448
0.82
0.55
1.5
1.4
—
—
—
0
0
30
240
1.26
0.54
2.1
2.0
3.29
4.49
iu/l
0.72
14
96
14
99
1.42
0.54
6.2
2.9
37.07
31.44
umol/l
0.69
14
88
37
447
0.82
0.54
1.5
1.4
—
—
—
0
0
9
62
1.46
0.53
1.2
1.5
—
—
—
0
0
19
143
1.34
0.53
1.1
1.0
1.87
2.14
u/ml
—
9
73
49
416
1.19
0.52
1.4
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
6
40
1.50
0.51
1.2
1.3
—
—
—
0
0
9
64
1.41
0.51
1.3
1.4
—
—
—
0
0
50
427
1.18
0.50
1.2
1.6
269.76
300.28
mu/l
0.33
45
375
6
41
1.47
0.50
1.3
1.0
—
—
—
0
0
13
93
1.40
0.48
1.2
1.2
—
—
—
0
0
73
823
0.88
0.48
1.5
1.6
—
—
—
0
0
55
477
1.16
0.47
4.5
4.2
1.49
2.59
ug/l
0.91
45
419
10
68
1.48
0.47
1.5
1.4
—
—
—
0
0
10
68
1.48
0.47
1.5
1.4
—
—
—
0
0
34
282
1.21
0.47
2.6
2.6
0.41
0.75
ug/l
3.34
18
169
18
138
1.31
0.45
1.2
1.2
—
—
—
0
0
15
112
1.35
0.45
1.2
1.3
—
—
—
0
0
15
112
1.35
0.45
1.2
1.3
—
—
—
0
0
30
359
0.83
0.42
1.5
1.7
—
—
—
0
0
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
24
195
1.24
0.41
1.2
1.5
0.43
0.41
nmol/l
0.07
16
162
11
79
1.40
0.41
24.3
2.1
66.27
60.95
%
0.43
11
79
11
79
1.40
0.41
1.0
1.4
—
—
—
0
0
64
570
1.13
0.40
1.6
1.7
—
—
—
0
0
13
97
1.35
0.39
1.6
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
162.03
—
0
19
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
11
80
1.38
0.38
1.3
1.4
—
—
—
0
0
17
213
0.79
0.37
1.2
1.2
—
—
—
0
0
5
77
0.65
0.36
1.2
1.4
33.88
35.51
nmol/l
—
5
68
29
341
0.85
0.35
1.8
1.9
—
—
—
0
0
48
542
0.88
0.35
1.4
1.4
—
—
—
0
0
6
43
1.40
0.35
4.8
2.0
—
—
—
0
0
43
377
1.15
0.34
3.7
3.9
21.18
22.18
%
0.11
15
165
32
274
1.17
0.34
14.2
9.4
0.83
0.67
%
1.11
32
274
32
274
1.17
0.34
13.6
9.4
1.23
1.34
%
0.42
32
274
12
91
1.32
0.34
1.4
1.4
—
—
—
0
0
56
505
1.12
0.31
10.1
9.5
0.92
1.11
mmol/l
0.14
44
405
11
84
1.31
0.30
1.0
1.1
—
—
—
0
0
170
1617
1.06
0.28
2.5
2.0
—
—
—
0
0
8
62
1.29
0.28
1.6
1.3
—
—
—
0
0
63
576
1.10
0.28
1.7
1.7
—
—
—
0
0
78
722
1.09
0.27
5.8
5.3
—
—
—
0
0
47
424
1.11
0.26
2.6
1.7
—
—
—
0
0
27
307
0.88
0.24
1.5
1.5
—
—
—
0
0
11
88
1.25
0.22
1.0
1.1
—
—
—
0
0
36
399
0.90
0.22
1.6
1.6
—
—
—
0
0
5
41
1.22
0.22
1.6
1.3
—
—
—
0
0
11
135
0.81
0.22
2.9
4.6
3.83
3.87
mmol/l
0.14
11
135
11
135
0.81
0.22
2.8
3.7
19.70
25.26
mg/l
—
5
83
5
42
1.19
0.21
1.8
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
2.2
1.8
13.69
24.00
ug/l
—
5
43
11
89
1.24
0.21
1.3
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
1.00
—
0
13
10
81
1.24
0.19
1.0
1.1
—
—
—
0
0
6
53
1.13
0.18
2.2
1.5
1.53
1.55
nmol/l
—
6
48
6
53
1.13
0.18
1.8
1.3
83.17
72.02
umol/l
—
6
53
6
53
1.13
0.18
1.0
1.3
—
—
—
0
0
15
128
1.17
0.18
1.1
1.1
—
—
—
0
0
7
61
1.15
0.17
2.4
2.1
105.43
106.44
mmol/l
—
7
61
22
195
1.13
0.17
1.4
1.4
340.67
308.96
ug/g
0.31
12
109
20
176
1.14
0.17
1.3
1.2
—
—
—
0
0
7
62
1.13
0.17
1.9
1.7
0.80
0.99
g/l
—
7
62
23
205
1.13
0.17
1.5
1.5
—
—
—
0
0
15
129
1.17
0.17
2.3
2.2
—
—
—
0
0
5
69
0.72
0.17
2.0
1.7
—
—
—
0
0
8
70
1.14
0.16
1.3
1.4
—
—
—
0
0
8
70
1.14
0.16
1.3
1.2
—
—
—
0
0
55
529
1.04
0.08
1.9
3.8
38.56
7.63
ug/l
0.43
42
412
7
65
1.08
0.08
1.1
1.5
—
—
—
0
0
84
864
0.97
0.08
1.6
1.6
1.40
1.33
%
0.65
70
775
42
439
0.95
0.07
1.4
1.4
—
—
—
0
0
13
118
1.10
0.07
1.6
2.4
52.77
135.58
ug/min
—
7
78
9
87
1.03
0.07
1.0
1.1
110.67
93.82
%
—
9
82
9
100
0.90
0.06
1.7
1.5
—
—
—
0
0
21
198
1.06
0.05
1.1
1.1
3.21
4.25
u/ml
0.25
14
97
14
138
1.01
0.00
2.1
1.9
—
—
—
0
0
25
248
1.01
0.00
1.5
1.4
58.27
189.44
pmol/l
1.26
25
243
29
288
1.01
0.00
1.4
1.6
—
—
—
0
0
12
117
1.03
0.00
1.3
1.4
6.46
7.01
mmol/l
0.24
12
103
12
119
1.01
0.00
1.0
1.0
0.02
0.08
u/ml
—
6
29
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
9
98
0.92
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PERIORALDERM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PERIORALDERM | 0.904 [0.74, 1.1] | 0.316 |
| Birth year | 0.996 [0.99, 1.0] | 0.35 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 2529 females with L12_PERIORALDERM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PERIORALDERM | 1.434 [1.09, 1.89] | 0.011 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 585 males with L12_PERIORALDERM died.
Mortality risk
Mortality risk for people of age
years, who have L12_PERIORALDERM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.262% |
| 5 | 0.583% | 1.442% |
| 10 | 1.383% | 3.6% |
| 15 | 2.476% | 7.047% |
| 20 | 4.8% | 12.19% |
Relationships between endpoints
↥Index endpoint: L12_PERIORALDERM – Perioral dermatitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data