Juvenile osteochondrosis

M13_JUVOSTEOCHONRHIP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M91, M92
  • Hospital discharge: ICD-9 7321X|732[3-6]
  • Hospital discharge: ICD-8 72209|7222[8-9]
  • Cause of death: ICD-10 M91, M92
  • Cause of death: ICD-9 7321X|732[3-6]
  • Cause of death: ICD-8 72209|7222[8-9]

2 out of 7 registries used, show all original rules.

1348

4. Check minimum number of events

None

1348

5. Include endpoints

None

1348

6. Filter based on genotype QC (FinnGen only)

1348

Control definitions (FinnGen only)

Control exclude
M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17161 7115 10008
Only index persons 15939 6633 9306
Unadjusted period prevalence (%)
Whole population 0.25 0.20 0.28
Only index persons 0.31 0.24 0.36
Median age at first event (years)
Whole population 14.72 14.39 14.83
Only index persons 14.83 14.62 14.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1348 762 586
Unadjusted period prevalence (%) 0.26 0.26 0.26
Median age at first event (years) 19.44 18.39 20.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1214
Matched controls
12140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M92.5
ICD-10 Finland
Juvenile osteochondrosis of tibia and fibula
594.3
291.5
278
6
M92.6
ICD-10 Finland
Juvenile osteochondrosis of tarsus
2454.4
205.1
193
*
M92.7
ICD-10 Finland
Juvenile osteochondrosis of metatarsus
656.3
122.5
119
*
M91.1
ICD-10 Finland
Juvenile osteochondrosis of head of femur [Legg-Calvé-Perthes]
1194.5
113.5
109
*
72209
ICD-8 Finland
Osteochondrosis, spinalis juvenilis (Scheuermann) NUD
+∞
101.5
96
*
7324B
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[OSTEOCHONDROSIS JUVENILIS TUBEROSITATIS TIBIAE]
+∞
98.3
93
*
M92.4
ICD-10 Finland
Juvenile osteochondrosis of patella
584.3
57.1
56
*
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
46.1
44
*
9102
FHL
Trepanation or removal of the local bone process
33.8
44.5
58
18
NGK05
NOMESCO Finland
Partial or total excision of bone of lower leg
99.9
44.1
48
5
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
14.3
39.7
68
50
M91.2
ICD-10 Finland
Coxa plana
+∞
38.7
37
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
21.2
35.9
53
26
M92.3
ICD-10 Finland
Other juvenile osteochondrosis of upper limb
+∞
28.2
27
*
M25.5
ICD-10 Finland
Pain in joint
2.2
28.2
370
2029
7323B
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of upper extremity[OSTEOCHONDROSIS JUVENILIS OSSIS LUNATUM CARPI]
+∞
26.1
25
*
7321A
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of hip and pelvis[COXA PLANA (LEGG-CALVô-PERTHES)]
+∞
25.1
24
*
7325X
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of foot
+∞
25.1
24
*
M79.6
ICD-10 Finland
Pain in limb
2.0
25.0
410
2446
M92.9
ICD-10 Finland
Juvenile osteochondrosis, unspecified
+∞
24.0
23
*
7324X
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[OSTEOCHONDROSIS JUVENILIS EXTREMITATIS INFER ALIA]
+∞
24.0
23
*
NGK99
NOMESCO Finland
Other operation on bone of knee or lower leg
42.3
23.7
29
7
M16.7
ICD-10 Finland
Other secondary coxarthrosis
18.5
23.6
36
20
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.3
23.4
89
218
M91.9
ICD-10 Finland
Juvenile osteochondrosis of hip and pelvis, unspecified
+∞
23.0
22
*
M01AH05
ATC
etoricoxib; oral
1.8
22.4
626
4474
M92.0
ICD-10 Finland
Juvenile osteochondrosis of humerus
+∞
21.9
21
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
9.7
21.7
44
47
M92.2
ICD-10 Finland
Juvenile osteochondrosis of hand
+∞
19.8
19
*
M91.0
ICD-10 Finland
Juvenile osteochondrosis of pelvis
+∞
19.8
19
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
19.8
415
2656
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
15.6
19.8
32
21
M92.8
ICD-10 Finland
Other specified juvenile osteochondrosis
203.1
19.6
20
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
19.3
950
7969
ZXA05
NOMESCO Finland
Left side
2.1
18.1
240
1288
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
4.0
17.9
73
191
B01AB05
ATC
enoxaparin; parenteral
2.0
16.7
259
1475
72228
ICD-8 Finland
Osteochondrosis, Juvenilis, alia definita
+∞
16.7
16
*
M16.3
ICD-10 Finland
Other dysplastic coxarthrosis
10.6
15.7
30
29
M01AE02
ATC
naproxen; oral, rectal
1.6
15.6
684
5338
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
15.4
480
3410
M16.1
ICD-10 Finland
Other primary coxarthrosis
3.0
15.4
93
330
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
32.1
14.8
19
6
M01AB05
ATC
diclofenac; systemic, rectal
1.6
14.5
685
5405
NGK00
NOMESCO Finland
Partial or total excision of bone of patella
151.7
14.5
15
*
NF1AA
NOMESCO Finland
Hip X-ray examination
3.1
14.4
81
272
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.1
14.0
80
274
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
13.7
333
2182
R4110
NOMESCO Finland
Physiotherapy
1.8
13.6
265
1621
M92.1
ICD-10 Finland
Juvenile osteochondrosis of radius and ulna
+∞
13.6
13
*
ZXA00
NOMESCO Finland
Right side
1.9
13.5
232
1361
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
13.4
104
431
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
11.6
13.3
24
21
M01AE01
ATC
ibuprofen; systemic, rectal
1.9
13.2
1060
9538
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
12.9
415
2936
L13
ICPC
Hip symptom/complaint
2.2
12.7
136
659
M54.5
ICD-10 Finland
Low back pain
1.6
12.6
368
2532
M02AA07
ATC
piroxicam; topical
1.7
12.2
295
1922
M01AC06
ATC
meloxicam; systemic, rectal
1.7
11.8
317
2124
NFB60
NOMESCO Finland
Demanding prosthetic replacement of hip
23.1
11.6
16
7
NHF25
NOMESCO Finland
Operation for debridement of ankle joint, arthroscopic
7.2
11.5
27
38
72211
ICD-8 Finland
Osteochondrosis, Coxae planae
+∞
11.5
11
*
9103
FHL
Partial or complete bone removal
121.1
11.4
12
*
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
3.1
11.3
61
203
M22.4
ICD-10 Finland
Chondromalacia patellae
3.3
11.2
56
176
WX320
NOMESCO Finland
Spinalanesthesy
1.8
11.2
200
1181
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
11.0
143
756
NGF40
NOMESCO Finland
Repair of defect of cartilage in the knee joint with transplant
43.7
10.9
13
*
NF1DA
NOMESCO Finland
X-ray of hips
5.6
10.9
31
57
M03BX02
ATC
tizanidine; oral
1.5
10.8
641
5176
N02AA05
ATC
oxycodone; systemic
2.3
10.8
100
455
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
10.7
409
2991
M93.1
ICD-10 Finland
Kienböck disease of adults
+∞
10.4
10
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.5
10.4
83
351
NGL30
NOMESCO Finland
Plastic repair or reinsertation of tendon of patella
32.8
10.3
13
*
N03AX16
ATC
pregabalin; oral
1.7
10.3
212
1309
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
10.3
91
405
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
13.2
10.2
17
13
R03AC02
ATC
salbutamol; inhalant
1.5
10.2
581
4633
M23.8
ICD-10 Finland
Other internal derangements of knee
3.2
9.9
51
165
M89.0
ICD-10 Finland
Algoneurodystrophy
20.2
9.8
14
7
X58
ICD-10 Finland
Exposure to other specified factors
1.8
9.7
178
1060
M77.4
ICD-10 Finland
Metatarsalgia
2.7
9.7
66
255
J01DB01
ATC
cefalexin; oral
1.6
9.7
938
8327
H02AB06
ATC
prednisolone; systemic
1.5
9.5
434
3282
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
9.4
111
562
7324A
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of lower extremity, excluding foot[TIBIA VARA (BLOUNT)]
+∞
9.4
9
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.8
9.1
57
208
1220
FHL
Arthroscopy
3.3
9.1
44
136
J01DA01
ATC
[U] cefalexin; systemic
1.4
9.1
660
5474
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
3.9
9.1
36
95
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.9
9.0
130
713
NEK20
NOMESCO Finland
Fenestration or forage of bone of pelvis
18.7
8.9
13
7
S18
ICPC
Laceration/cut
1.5
8.9
391
2924
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
8.9
854
7476
RF420
NOMESCO Finland
NA
8.0
8.9
19
24
A02BC02
ATC
pantoprazole; systemic
1.4
8.8
582
4725
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
8.7
271
1870
N03AX12
ATC
gabapentin; oral
1.8
8.6
141
806
L15
ICPC
Knee symptom/complaint
1.7
8.6
201
1288
J01FA10
ATC
azithromycin; systemic
1.4
8.6
728
6191
NFK20
NOMESCO Finland
Epiphysiodesis of femur
27.7
8.5
11
*
M01AH03
ATC
valdecoxib; oral
2.6
8.4
58
227
M93.9
ICD-10 Finland
Osteochondropathy, unspecified
+∞
8.3
8
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
4.1
8.3
31
78
9165
FHL
Removal of osteosynthesis material
4.3
8.2
29
69
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.1
8.2
95
479
SPAT1153
SPAT
Removal of sutures
1.5
8.2
277
1951
R51.80
ICD-10 Finland
Headache
1.7
8.1
192
1233
RF410
NOMESCO Finland
NA
7.3
8.0
18
25
J01FF01
ATC
clindamycin; systemic
1.6
8.0
260
1811
N06AX21
ATC
duloxetine; oral
1.9
7.9
112
610
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
7.9
194
1257
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
7.8
131
755
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
2.8
7.8
49
181
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
7.7
484
3859
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
7.7
201
1322
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.6
264
1864
NCF25
NOMESCO Finland
Operation for osteochondritis of elbow joint, arthroscopic
11.9
7.6
13
11
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
7.5
243
1686
M01AH02
ATC
rofecoxib; oral
2.1
7.5
88
444
R06.0
ICD-10 Finland
Dyspnoea
1.6
7.4
200
1328
9527
FHL
Alloarthroplasty, implant or endoprosthesis
80.5
7.4
8
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
3.1
7.3
37
120
72219
ICD-8 Finland
Osteochondrosis, Coxae juvenilis NUD
+∞
7.3
7
*
72220
ICD-8 Finland
Osteochondrosis, Malacia ossia lunati (Kienböck)
+∞
7.3
7
*
7327A
ICD-9 Finland
Osteochondropathies, Osteochondritis dissecans[OSTEOCHONDRITIS DISSECANS GENUS]
+∞
7.3
7
*
M01AX17
ATC
nimesulide; oral
1.7
7.3
170
1084
M20.1
ICD-10 Finland
Hallux valgus (acquired)
2.4
7.3
61
267
L17
ICPC
Foot/toe symptom/complaint
1.5
7.2
247
1737
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.6
7.2
194
1288
9407
FHL
Osteotomy of the upper femur
30.2
7.2
9
*
NGF30
NOMESCO Finland
Fixation of loose body of joint of knee
30.2
7.2
9
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
5.3
7.1
20
38
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
6.9
64
294
M01AH01
ATC
celecoxib; oral (coxibs)
1.7
6.9
130
782
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.1
6.8
70
339
W19
ICD-10 Finland
Unspecified fall
1.9
6.7
97
534
A02BC01
ATC
omeprazole; systemic
1.5
6.7
230
1614
L03
ICPC
Low back symptom/complaint
1.5
6.6
253
1817
M19.2
ICD-10 Finland
Other secondary arthrosis
5.9
6.6
17
29
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
6.6
162
1048
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
6.6
187
1255
R09
ICPC
Sinus symptom/complaint
1.9
6.6
94
516
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
8.7
6.6
13
15
E66.01
ICD-10 Finland
Obesity due to excess calories
1.9
6.5
93
509
WX110
NOMESCO Finland
Local anesthesy
1.4
6.5
812
7208
L16
ICPC
Ankle symptom/complaint
1.7
6.5
123
742
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
6.5
277
2039
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
5.7
6.5
17
30
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
3.8
6.4
25
67
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
3.8
6.4
25
67
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
3.1
6.3
32
106
7323X
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of upper extremity[OSTEOCHONDROSIS JUVENILIS EXTREMITATIS SUPER ALIA]
+∞
6.3
6
*
7326A
ICD-9 Finland
Osteochondropathies, Other juvenile osteochondrosis
+∞
6.3
6
*
M91.3
ICD-10 Finland
Pseudocoxalgia
+∞
6.3
6
*
RF210
NOMESCO Finland
NA
3.1
6.2
31
101
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
5.1
6.2
18
36
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
6.1
348
2708
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.0
241
1748
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.9
6.0
35
125

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
885
7473
1.54
12.16
4.4
3.7
9.7
9.4
mm/h
0.30
840
6953
862
7372
1.47
10.08
7.4
6.7
75.7
76.8
u/l
0.33
819
6955
684
5607
1.45
9.95
5.2
4.5
6.5
6.5
mmol/l
0.02
638
5109
396
2925
1.50
9.85
2.6
2.5
57.3
56.9
u/l
0.04
363
2717
407
3098
1.45
8.46
3.0
3.0
24.6
35.1
ng/l
0.79
209
1726
587
4777
1.41
8.38
4.3
3.9
—
—
—
0
0
1183
10981
1.63
7.94
14.1
10.8
20.1
21.5
mg/l
0.76
939
8388
936
8315
1.41
7.60
4.1
3.7
14.4
14.5
pmol/l
0.42
873
7638
326
2428
1.45
7.47
2.4
2.1
409.5
247.4
u/l
0.32
311
2300
1077
9827
1.48
7.47
4.8
4.3
1.8
2.1
mu/l
1.00
1020
9196
574
4719
1.38
7.43
6.1
5.7
10.3
11.2
umol/l
2.00
543
4447
303
2240
1.45
7.19
3.3
2.5
2684.7
4360.5
umol/l
0.43
275
2022
519
4254
1.36
6.64
7.6
6.5
1.2
1.2
mmol/l
0.31
444
3612
1133
10535
1.47
6.26
14.5
11.5
139.4
139.6
mmol/l
2.30
1114
10224
1134
10566
1.46
6.00
14.7
11.5
3.9
3.9
mmol/l
1.03
1114
10230
763
6695
1.32
5.86
4.3
3.7
2268.6
1171.1
e6/l
0.21
14
78
399
3191
1.36
5.82
7.8
6.8
1.1
1.1
inr
0.17
123
1030
215
1551
1.46
5.71
3.5
3.2
724.7
597.9
ng/l
0.13
137
1005
49
236
2.12
5.59
3.9
7.9
1.3
1.2
mmol/l
0.56
40
199
465
3831
1.33
5.49
6.6
6.0
1.2
1.2
mmol/l
0.81
433
3499
236
1765
1.41
5.13
1.3
1.3
30.0
25.2
iu/ml
0.20
62
537
123
807
1.58
5.11
1.3
1.3
1050.2
257.1
u/ml
0.49
115
754
24
87
2.79
5.05
1.5
1.6
56.3
56.0
%
0.01
18
65
225
1673
1.41
5.05
1.3
1.2
9.1
8.7
u/ml
0.03
84
688
129
863
1.55
4.93
4.0
3.2
1.7
1.7
%
0.00
115
780
31
130
2.42
4.91
1.5
1.7
—
—
—
0
0
802
7177
1.29
4.89
4.3
3.8
—
—
—
0
0
68
391
1.78
4.67
1.3
1.2
0.5
1.1
u/ml
—
6
29
69
402
1.76
4.54
9.4
11.8
—
—
—
0
0
38
182
2.12
4.45
1.6
1.7
17654.1
12433.2
e6/l
0.39
25
134
370
3033
1.30
4.36
2.6
2.2
—
—
—
0
0
289
2291
1.33
4.32
2.0
1.9
0.9
1.0
mg/l
0.37
215
1660
1041
9715
1.31
4.22
3.9
3.5
5.8
5.7
mmol/l
0.76
968
9016
174
1279
1.41
4.16
2.3
1.9
—
—
—
0
0
436
3671
1.28
4.14
5.4
4.8
37.4
36.9
g/l
1.06
411
3426
289
2305
1.32
4.13
2.5
2.1
—
—
—
0
0
309
2490
1.31
4.10
3.9
3.6
7.4
7.4
ph
0.45
53
487
365
3008
1.29
4.09
1.4
1.3
1.7
1.7
u/ml
0.00
94
799
33
155
2.16
4.08
4.8
10.1
11.3
11.3
mmol/l
0.00
27
138
347
2844
1.30
4.05
3.0
3.0
2.3
2.4
mmol/l
0.41
313
2552
274
2174
1.33
4.05
4.9
4.1
—
—
—
0
0
316
2558
1.31
4.05
3.1
2.9
0.3
0.3
e6/l
0.04
237
1899
395
3295
1.28
4.02
1.8
1.8
101.0
95.8
pmol/l
1.26
209
1831
33
156
2.14
4.02
4.8
10.1
104.8
105.4
mmol/l
0.34
27
139
245
1916
1.34
4.00
2.7
2.4
5.9
6.9
e6/l
0.45
211
1680
413
3468
1.28
3.98
3.8
3.3
59.5
86.4
e6/l
0.43
287
2323
156
1135
1.42
3.95
8.4
6.4
1.1
1.1
mmol/l
0.21
151
1062
108
732
1.52
3.92
8.1
9.7
96.2
96.1
%
0.09
101
706
197
1499
1.37
3.84
1.5
1.3
435.0
503.3
titre
0.34
48
278
50
281
1.81
3.76
3.7
7.0
0.8
0.9
%
1.33
44
261
16
55
2.93
3.74
2.5
4.4
208.2
159.1
umol/l
0.29
11
32
1201
11503
1.40
3.70
10.1
8.6
28.3
27.7
u/l
0.41
1167
11151
152
1115
1.41
3.69
3.7
2.8
5.6
7.4
umol/l
1.31
131
950
628
5570
1.24
3.68
6.9
6.0
2.0
2.0
e9/l
0.02
559
4968
682
6110
1.24
3.62
9.7
8.5
4.1
4.0
e9/l
0.53
600
5345
49
282
1.77
3.43
3.8
7.0
1.7
1.6
%
0.15
43
260
309
2547
1.28
3.40
3.1
2.8
—
—
—
0
0
587
5202
1.23
3.38
4.4
4.2
0.0
0.0
estimate
0.50
120
1043
592
5252
1.23
3.37
6.9
5.8
56.3
56.0
%
0.23
558
4967
603
5360
1.23
3.36
7.0
6.0
0.0
0.0
e9/l
0.41
527
4690
556
4901
1.23
3.36
7.0
6.1
0.6
0.7
%
0.30
522
4615
12
37
3.26
3.34
1.1
1.3
—
—
—
0
0
21
89
2.38
3.32
1.1
1.0
—
—
—
0
0
599
5327
1.22
3.31
7.0
6.0
29.0
29.7
%
0.79
562
5022
591
5249
1.22
3.31
3.2
3.1
0.0
0.0
estimate
0.50
117
999
292
2398
1.28
3.30
4.6
3.9
90.4
93.2
%
1.18
286
2334
621
5547
1.22
3.27
7.5
6.3
0.2
0.2
e9/l
1.31
553
4930
585
5201
1.22
3.21
3.2
3.1
0.0
0.0
estimate
0.80
118
999
214
1694
1.31
3.20
1.6
1.6
33333753.6
33196016.5
pmol/l
0.00
177
1452
599
5343
1.22
3.17
7.0
6.0
0.6
0.6
e9/l
0.61
523
4673
334
2802
1.26
3.15
3.4
2.9
31.5
82.9
e6/l
1.19
262
2135
233
1870
1.30
3.14
1.7
1.4
19.1
20.4
nmol/l
0.87
207
1616
573
5106
1.21
3.02
7.5
6.2
8.3
8.4
%
0.27
539
4826
115
835
1.41
2.99
7.9
8.8
5.0
5.1
kpa
0.40
109
795
129
956
1.39
2.98
3.0
2.4
2165.8
5707.2
u/l
1.77
44
365
273
2251
1.27
2.97
4.4
4.2
10.6
10.3
mg/mmol
0.04
194
1493
292
2429
1.26
2.95
2.3
2.1
2.6
2.7
mg/l
0.38
252
2092
46
273
1.71
2.94
1.5
2.0
2.9
2.3
ug/l
0.10
41
250
568
5071
1.21
2.90
7.1
6.0
2.8
2.8
%
0.02
534
4754
14
52
2.71
2.89
1.2
1.4
—
—
—
0
0
312
2621
1.25
2.89
4.5
4.3
—
—
—
0
0
15
58
2.60
2.88
1.1
1.4
34.5
32.7
g/l
0.24
15
51
114
835
1.40
2.83
7.9
8.8
12.9
13.2
kpa
0.25
108
799
68
450
1.54
2.82
3.5
6.0
—
—
—
0
0
311
2624
1.24
2.76
1.6
1.4
2.0
2.2
g/l
1.08
204
1645
109
796
1.40
2.76
3.8
4.6
1.0
0.9
%
0.05
25
225
73
494
1.51
2.74
2.8
3.0
111.0
168.2
ng/l
1.34
66
432
938
8809
1.21
2.70
5.3
4.5
38.8
38.3
mmol/mol
0.86
890
8304
80
557
1.46
2.63
2.3
2.2
5.1
8.2
ug/l
1.35
70
504
92
659
1.43
2.61
1.3
1.2
—
—
—
0
0
52
330
1.60
2.60
1.2
1.2
—
—
—
0
0
61
402
1.54
2.60
3.1
3.1
22.0
21.4
s
0.55
50
359
106
779
1.39
2.60
9.7
8.8
—
—
—
0
0
100
729
1.40
2.57
3.4
4.3
0.3
0.5
%
0.56
15
164
170
1345
1.30
2.56
5.7
3.9
0.8
0.8
mmol/l
0.14
164
1271
403
3518
1.21
2.54
7.3
6.0
—
—
—
0
0
95
688
1.41
2.54
8.9
10.0
123.6
124.6
g/l
0.18
89
662
152
1186
1.32
2.54
1.7
1.6
—
—
—
0
0
61
405
1.53
2.53
2.0
2.1
—
—
—
0
0
24
122
1.98
2.51
1.5
1.4
—
—
—
0
0
151
1180
1.31
2.50
2.9
2.4
22.5
24.2
%
0.73
129
1022
175
1396
1.29
2.48
2.8
2.3
13.1
14.4
umol/l
1.64
159
1291
1062
10128
1.23
2.48
4.0
3.6
4.7
4.7
mmol/l
0.04
1008
9577
13
51
2.56
2.44
1.1
1.4
—
—
—
0
0
256
2143
1.24
2.43
3.7
3.4
66.3
216.5
mg/l
1.49
176
1440
97
711
1.39
2.43
1.6
1.6
354.0
303.7
mu/l
0.58
89
631
111
832
1.36
2.43
8.1
8.9
0.5
0.9
mmol/l
0.46
89
649
103
763
1.38
2.42
3.6
4.7
0.1
0.1
%
0.28
23
209
1070
10221
1.23
2.41
4.3
3.9
2.8
2.8
mmol/l
0.26
1005
9599
98
723
1.38
2.37
3.7
4.7
0.0
0.1
%
1.52
21
181
64
436
1.49
2.37
4.7
8.4
24.9
24.3
mmol/l
0.60
57
404
1202
11640
1.30
2.37
12.4
9.9
—
—
—
0
0
155
1226
1.30
2.35
1.2
1.2
—
—
—
0
0
425
3757
1.19
2.31
2.0
1.9
—
—
—
0
0
9
28
3.23
2.31
3.4
1.6
—
—
—
0
0
22
113
1.96
2.26
3.5
2.5
1.3
1.3
e9/l
0.08
16
63
22
113
1.96
2.26
1.4
1.6
—
—
—
0
0
109
828
1.34
2.21
2.9
2.6
10.3
10.4
g/l
0.18
97
755
1053
10074
1.21
2.16
3.9
3.6
1.4
1.4
mmol/l
0.68
992
9498
21
108
1.96
2.16
2.5
1.8
—
—
—
0
0
161
1296
1.28
2.15
2.8
2.3
2.4
2.4
g/l
0.28
146
1196
136
1074
1.30
2.11
1.2
1.2
—
—
—
0
0
578
5274
1.17
2.11
3.2
2.8
101.6
93.5
ug/l
0.36
547
4946
531
4813
1.17
2.11
9.7
8.5
0.0
0.0
e9/l
0.80
435
3917
162
1309
1.27
2.10
3.0
2.5
29.7
29.6
s
0.11
156
1274
16
75
2.15
2.09
1.4
1.2
—
—
—
0
0
110
847
1.33
2.05
5.8
4.5
1.2
1.6
mmol/l
1.01
95
681
1011
9653
1.19
2.04
3.6
3.3
1.3
1.3
mmol/l
1.91
960
9090
83
613
1.38
2.03
3.6
2.9
65.1
71.3
e9/l
0.77
67
452
98
744
1.34
2.01
2.2
2.3
12.0
21.1
au/ml
—
5
58
215
1807
1.23
1.97
2.9
2.6
565.0
569.0
mosm/kgh2o
0.08
182
1559
21
112
1.89
1.97
1.1
1.1
0.6
2.4
u/ml
—
10
43
5
11
4.56
1.94
1.0
1.1
—
—
—
0
0
270
2327
1.20
1.92
3.1
3.1
—
—
—
0
0
16
78
2.06
1.91
1.1
1.1
—
—
—
0
0
17
85
2.01
1.90
1.1
1.0
24.0
7.3
iu/ml
—
5
22
52
357
1.47
1.90
1.3
1.2
—
—
—
0
0
298
2597
1.19
1.87
2.6
2.4
—
—
—
0
0
47
318
1.50
1.85
1.9
2.0
1.4
1.4
g/l
0.07
39
284
17
86
1.99
1.85
1.2
1.2
—
—
—
0
0
22
122
1.82
1.84
3.2
3.5
—
—
—
0
0
7
23
3.05
1.80
1.0
1.7
—
—
—
0
0
173
1437
1.23
1.79
3.0
2.6
2.8
2.8
e6/l
0.00
100
763
692
6459
1.15
1.75
3.4
3.1
—
—
—
0
0
87
666
1.33
1.72
2.0
1.8
1.3
1.3
g/l
0.15
81
616
128
1033
1.26
1.71
1.3
1.4
—
—
—
0
0
114
907
1.28
1.71
2.5
2.4
43.9
91.7
u/l
0.42
96
770
105
827
1.29
1.70
21.9
15.5
1.0
1.2
inr
3.34
20
131
319
2821
1.17
1.68
3.7
3.4
8.0
8.5
mmol/l
1.07
285
2422
17
90
1.90
1.65
3.9
2.4
9.8
10.8
%
0.19
12
51
1281
12593
1.35
1.60
19.9
15.6
30.1
30.0
pg
0.20
1271
12446
1281
12593
1.35
1.60
19.9
15.7
89.9
89.7
fl
0.50
1271
12447
1280
12582
1.34
1.60
20.0
15.7
256.9
256.1
e9/l
0.19
1257
12276
71
535
1.35
1.58
1.1
1.1
—
—
—
0
0
84
649
1.31
1.58
1.1
1.2
—
—
—
0
0
1281
12595
1.34
1.58
20.0
15.7
4.6
4.6
e12/l
0.87
1256
12270
213
1831
1.19
1.57
3.0
3.2
1205.7
992.9
ng/l
0.31
176
1483
54
390
1.40
1.56
2.0
2.2
—
—
—
0
0
195
1664
1.20
1.56
2.6
2.6
91.7
113.7
ug/g
0.90
161
1334
5
15
3.34
1.52
1.0
1.1
—
—
—
0
0
1281
12601
1.33
1.51
20.0
15.8
6.8
6.7
e9/l
1.07
1255
12274
6
21
2.87
1.50
1.2
1.1
—
—
—
0
0
1281
12603
1.33
1.49
20.1
15.8
137.1
137.6
g/l
0.65
1271
12451
36
243
1.49
1.48
1.0
1.1
5.2
7.2
u/ml
0.18
16
101
266
2343
1.17
1.47
1.9
1.8
—
—
—
0
0
10
45
2.23
1.46
1.1
1.3
146.9
147.9
nmol/l
—
10
45
66
499
1.34
1.46
1.1
1.1
—
—
—
0
0
279
2470
1.16
1.45
1.6
1.6
1.5
1.4
mmol/l
0.93
244
2152
5
16
3.13
1.44
1.6
1.3
—
—
—
0
0
406
3700
1.14
1.40
2.2
2.1
—
—
—
0
0
136
1133
1.22
1.40
1.7
1.5
—
—
—
0
0
80
627
1.29
1.38
1.3
1.4
—
—
—
0
0
309
2768
1.15
1.37
3.4
3.3
0.0
0.0
estimate
1.08
115
1012
30
199
1.52
1.35
1.6
1.2
—
—
—
0
0
26
167
1.57
1.35
3.0
3.3
31.8
30.1
mg/l
0.08
20
134
26
167
1.57
1.35
3.0
3.3
214.2
86.4
mg/l
0.35
20
134
14
75
1.88
1.34
1.0
1.1
1.1
1.1
ratio
—
5
31
86
684
1.27
1.34
1.5
1.5
14.6
19.1
iu/l
1.21
74
562
17
99
1.73
1.27
3.7
3.9
—
—
—
0
0
9
44
2.05
1.27
1.2
1.3
—
—
—
0
0
37
261
1.43
1.26
1.4
1.5
0.3
0.3
nmol/l
0.10
31
219
6
25
2.41
1.24
1.0
1.0
—
—
—
0
0
6
25
2.41
1.24
1.0
1.0
—
—
—
0
0
6
25
2.41
1.24
1.0
1.0
—
—
—
0
0
260
2319
1.15
1.23
3.3
3.2
1.0
1.0
kg/l
0.84
30
319
1043
10111
1.14
1.23
17.1
13.2
334.1
334.0
g/l
0.16
1038
10033
10
49
2.05
1.22
1.4
1.3
—
—
—
0
0
132
1115
1.20
1.21
1.5
1.4
—
—
—
0
0
21
132
1.60
1.20
2.7
3.4
2.4
1.3
%
0.28
16
109
159
1370
1.18
1.17
2.6
2.7
2.4
2.4
mmol/l
0.61
138
1200
41
300
1.38
1.15
1.2
1.4
3.5
3.4
ug/l
0.07
41
280
37
266
1.40
1.15
1.1
1.0
4.0
5.7
u/ml
0.33
16
102
5
20
2.51
1.15
10.6
15.6
—
—
—
0
0
20
126
1.60
1.15
1.4
1.2
—
24.8
—
0
8
50
379
1.33
1.13
1.1
1.1
0.3
2.3
u/ml
2.72
23
163
46
346
1.34
1.10
1.0
1.1
10.4
6.7
u/ml
0.43
21
202
7
32
2.19
1.08
1.4
1.8
—
—
—
0
0
15
89
1.69
1.07
2.7
2.4
575.6
730.7
e6/l
—
5
36
10
52
1.93
1.06
3.0
2.9
—
—
—
0
0
64
510
1.27
1.03
1.4
1.3
—
—
—
0
0
11
60
1.84
1.03
1.6
2.6
21.9
538.1
ug/l
0.68
11
54
19
122
1.57
1.02
3.4
3.1
18.3
30.1
mu/l
0.89
19
115
117
998
1.19
1.00
8.5
7.2
105.0
104.4
mmol/l
0.72
117
978
333
3060
1.12
0.99
2.8
2.7
—
—
—
0
0
89
740
1.22
0.99
5.3
3.9
—
—
—
0
0
14
84
1.67
0.98
1.1
1.2
—
—
—
0
0
212
1897
1.14
0.98
1.9
1.6
—
—
—
0
0
86
714
1.22
0.97
2.4
2.4
4.0
4.1
e9/l
0.20
67
595
19
124
1.54
0.97
1.0
1.1
0.7
1.5
u/ml
—
5
47
40
302
1.33
0.96
1.8
1.4
—
—
—
0
0
25
174
1.45
0.95
1.0
1.2
—
—
—
0
0
25
174
1.45
0.95
1.9
1.9
0.7
0.8
g/l
0.33
17
137
7
37
1.90
0.94
1.0
4.0
—
—
—
0
0
43
330
1.31
0.93
1.0
1.1
1.2
3.5
u/ml
1.72
12
79
39
295
1.33
0.93
3.1
4.6
—
—
—
0
0
46
358
1.29
0.91
1.3
1.1
—
—
—
0
0
146
1280
1.16
0.91
1.7
1.7
1283.4
1168.7
nmol/l
0.76
117
990
82
684
1.21
0.90
3.0
3.4
4.8
4.7
pmol/l
0.11
70
616
6
29
2.07
0.89
1.0
1.1
—
—
—
0
0
12
71
1.70
0.89
1.2
1.2
—
56.0
—
0
6
59
477
1.25
0.87
11.2
10.5
1.1
1.4
%
2.62
59
472
8
44
1.82
0.86
5.6
3.7
—
—
—
0
0
28
204
1.38
0.85
4.0
3.3
17.4
24.5
mg/l
1.01
17
126
16
104
1.54
0.84
1.8
1.4
0.3
0.4
g/l
0.14
11
72
16
104
1.54
0.84
1.8
1.4
5.8
6.5
g/l
0.47
11
74
16
104
1.54
0.84
1.8
1.4
2.9
2.6
g/l
0.31
11
74
6
31
1.94
0.84
2.2
2.2
—
—
—
0
0
53
426
1.25
0.83
1.7
1.7
—
—
—
0
0
8
46
1.74
0.82
2.8
2.6
—
—
—
0
0
19
130
1.47
0.81
2.0
2.3
—
—
—
0
0
15
224
0.67
0.80
1.4
1.5
—
—
—
0
0
29
216
1.35
0.79
1.0
1.1
1.2
2.7
u/ml
1.73
19
106
11
66
1.67
0.78
2.8
2.6
37.6
45.4
%
—
5
19
14
90
1.56
0.78
1.9
1.8
33.6
32.8
pg
0.30
14
90
53
430
1.24
0.78
3.3
2.4
0.1
0.1
e6/l
0.11
53
415
31
234
1.33
0.78
2.6
2.4
—
—
—
0
0
11
67
1.65
0.75
1.3
1.1
—
—
—
0
0
42
334
1.27
0.74
1.0
1.1
0.4
1.1
u/ml
0.86
16
154
20
143
1.40
0.70
2.7
2.4
—
—
—
0
0
5
27
1.85
0.68
1.0
1.3
—
8.5
%
—
0
6
5
27
1.85
0.68
1.0
1.2
—
—
—
0
0
39
311
1.26
0.68
8.4
8.8
—
—
—
0
0
18
127
1.42
0.68
1.4
1.4
—
—
—
0
0
7
43
1.63
0.67
1.0
1.0
—
—
—
0
0
7
44
1.59
0.65
1.0
1.1
—
—
—
0
0
8
128
0.62
0.64
1.4
1.2
—
—
—
0
0
74
636
1.17
0.64
2.8
4.2
4.7
14.9
ug/l
0.82
60
504
82
942
0.86
0.63
1.4
1.3
—
—
—
0
0
275
2568
1.09
0.61
8.2
6.4
—
—
—
0
0
73
630
1.17
0.61
1.4
1.3
246.9
243.8
miu/ml
0.02
34
303
8
51
1.57
0.60
2.8
2.4
—
—
—
0
0
106
942
1.14
0.59
3.3
3.4
—
—
—
0
0
14
97
1.45
0.59
1.1
1.1
—
—
—
0
0
24
184
1.31
0.58
1.8
2.4
130.9
133.7
g/l
0.16
17
142
15
106
1.42
0.57
1.9
1.3
—
—
—
0
0
65
559
1.17
0.57
1.3
1.6
6.0
8.2
u/l
1.71
52
446
6
36
1.67
0.56
2.3
1.8
—
—
—
0
0
11
73
1.51
0.56
1.0
1.2
—
—
—
0
0
18
133
1.36
0.55
1.1
1.4
—
—
—
0
0
53
450
1.19
0.54
5.4
4.3
—
—
—
0
0
71
618
1.16
0.54
2.4
2.3
—
—
—
0
0
71
619
1.16
0.53
4.7
3.9
5.2
5.1
kpa
0.35
64
582
15
108
1.39
0.53
1.2
1.3
—
—
—
0
0
29
233
1.25
0.51
2.1
1.6
—
—
—
0
0
35
288
1.22
0.50
1.9
1.4
97.8
99.5
u/ml
—
6
52
6
41
1.47
0.50
1.0
3.6
—
—
—
0
0
6
41
1.47
0.50
1.0
2.1
7.7
9.1
mmol/l
—
6
34
240
2252
1.08
0.49
3.5
3.1
—
—
—
0
0
7
45
1.56
0.49
1.0
1.0
—
—
—
0
0
29
235
1.24
0.48
1.0
1.0
0.8
0.4
u/ml
—
8
54
19
244
0.78
0.47
1.5
1.1
—
—
—
0
0
23
182
1.27
0.46
1.1
1.3
2.9
5.8
u/ml
—
7
78
23
182
1.27
0.46
2.3
2.4
—
—
—
0
0
259
2445
1.07
0.46
3.7
3.9
1.6
1.9
ug/l
0.96
234
2233
21
165
1.28
0.45
3.3
2.4
17.0
16.7
%
—
10
83
7
50
1.40
0.45
2.6
1.7
—
—
—
0
0
76
678
1.13
0.44
4.3
3.1
—
—
—
0
0
81
727
1.12
0.43
2.6
3.1
—
—
—
0
0
1098
10840
1.07
0.42
14.7
11.4
40.3
40.7
%
0.90
865
8829
105
958
1.10
0.42
1.2
1.2
195.0
145.4
iu/ml
0.46
42
374
30
249
1.21
0.42
2.0
1.6
943.4
908.5
e6/l
0.01
25
197
30
249
1.21
0.42
2.0
1.5
5.5
9.8
e6/l
0.62
24
189
8
58
1.38
0.41
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
1535.9
—
0
15
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.47
0.40
1.6
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
305
2912
1.06
0.39
1.9
1.7
—
—
—
0
0
13
97
1.34
0.39
3.5
4.0
—
—
—
0
0
434
4187
1.05
0.39
2.3
2.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
21
169
1.25
0.38
1.2
1.2
—
—
—
0
0
68
609
1.12
0.38
4.8
3.9
7.4
7.4
ph
—
8
66
11
80
1.38
0.38
3.7
2.5
—
—
—
0
0
9
66
1.37
0.38
2.6
3.7
—
—
—
0
0
9
67
1.35
0.38
1.0
1.1
—
—
—
0
0
9
68
1.33
0.37
1.1
1.1
1749.4
1559.1
miu/ml
—
9
68
383
3687
1.05
0.37
1.8
1.6
—
—
—
0
0
14
107
1.31
0.37
1.5
1.4
471.7
362.9
pmol/l
—
9
84
16
125
1.28
0.37
1.8
1.7
—
—
—
0
0
10
72
1.39
0.37
1.3
1.2
—
—
—
0
0
36
309
1.17
0.36
1.2
1.3
—
—
—
0
0
24
198
1.22
0.36
1.1
1.1
24.3
129.7
iu/ml
—
5
58
11
81
1.36
0.36
3.7
2.5
4.4
4.0
mmol/l
0.56
11
81
11
81
1.36
0.36
3.7
2.5
102.6
105.7
mmol/l
1.22
11
81
12
157
0.76
0.36
1.9
2.9
—
—
—
0
0
5
78
0.64
0.35
1.2
1.6
1.0
1.0
g/l
—
5
78
14
108
1.30
0.35
1.3
1.5
1.0
1.3
promille
—
9
88
129
1201
1.08
0.35
1.6
1.5
—
—
—
0
0
207
1962
1.07
0.35
1.6
1.5
—
—
—
0
0
30
255
1.18
0.34
1.3
1.5
348.1
306.9
ug/g
0.47
13
137
29
246
1.18
0.34
1.2
1.1
—
7.8
—
0
22
125
1339
0.93
0.33
2.0
1.9
—
—
—
0
0
978
9653
1.05
0.32
16.8
13.2
13.4
13.4
%
0.14
963
9457
7
54
1.30
0.30
3.9
3.8
1043.9
707.4
u/ml
—
7
54
33
287
1.15
0.30
2.1
2.3
7.0
5.5
umol/l
0.23
22
221
24
203
1.19
0.30
1.3
1.1
—
—
—
0
0
27
231
1.17
0.30
1.1
1.1
—
—
—
0
0
37
325
1.14
0.30
1.4
1.3
—
—
—
0
0
7
57
1.23
0.29
1.1
1.1
—
—
—
0
0
73
671
1.09
0.28
1.3
1.3
—
—
—
0
0
166
1577
1.06
0.27
1.2
1.3
—
—
—
0
0
9
72
1.25
0.25
2.1
2.9
—
—
—
0
0
22
256
0.86
0.25
4.0
3.4
39.0
1202.2
u/ml
1.00
22
216
13
105
1.24
0.25
1.0
1.0
—
—
—
0
0
6
81
0.74
0.24
1.0
1.5
—
—
—
0
0
5
39
1.28
0.23
1.6
2.1
—
—
—
0
0
101
952
1.07
0.23
2.2
2.2
13.3
12.5
nmol/l
0.36
90
860
26
228
1.14
0.22
1.3
1.1
—
—
—
0
0
5
40
1.25
0.22
1.2
1.6
—
—
—
0
0
5
40
1.25
0.22
1.0
1.4
—
—
—
0
0
18
210
0.86
0.22
3.1
3.0
—
—
—
0
0
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
22
191
1.15
0.22
5.8
3.6
—
—
—
0
0
49
451
1.09
0.20
1.4
1.6
—
—
—
0
0
11
90
1.22
0.19
2.6
3.4
—
—
—
0
0
10
81
1.24
0.18
1.4
1.3
—
—
—
0
0
70
658
1.07
0.18
3.2
3.3
1.2
1.2
mmol/l
1.63
62
572
7
60
1.17
0.17
1.9
2.0
—
—
—
0
0
45
416
1.08
0.17
2.9
2.9
—
—
—
0
0
21
186
1.13
0.17
3.4
3.8
—
—
—
0
0
13
111
1.17
0.15
1.2
1.9
—
—
—
0
0
24
216
1.11
0.15
2.5
3.7
3.9
3.9
e9/l
0.07
24
216
12
102
1.18
0.15
2.4
1.8
—
—
—
0
0
7
86
0.81
0.14
1.0
1.0
—
—
—
0
0
138
1425
0.96
0.13
2.4
2.6
0.6
0.7
ug/l
1.67
73
803
32
296
1.08
0.13
2.0
1.9
4.2
5.5
iu/l
0.42
14
118
17
190
0.89
0.13
2.2
2.7
246.2
159.3
ug/min
—
10
117
13
148
0.88
0.12
1.9
2.6
21.8
24.8
nmol/l
0.45
13
142
44
467
0.94
0.12
2.7
3.0
—
—
—
0
0
20
219
0.91
0.11
3.0
4.3
3.7
3.9
mmol/l
1.08
20
203
24
221
1.09
0.11
2.6
4.1
56.9
55.2
%
0.31
24
221
13
115
1.13
0.10
1.5
1.5
—
19.2
—
0
6
37
349
1.06
0.10
6.2
4.2
0.3
0.3
g/l
0.08
19
170
5
44
1.14
0.10
3.4
1.9
15.5
16.3
umol/l
—
5
44
82
849
0.96
0.10
2.0
2.2
—
—
—
0
0
10
114
0.88
0.09
1.2
1.3
—
—
—
0
0
7
67
1.05
0.08
1.6
1.3
—
—
—
0
0
7
68
1.03
0.08
2.1
3.0
1.0
0.9
nmol/l
—
7
49
8
75
1.07
0.07
6.5
2.1
—
—
—
0
0
8
76
1.05
0.07
10.6
4.4
11.1
11.8
%
—
8
76
17
184
0.92
0.07
1.4
1.2
—
—
—
0
0
9
85
1.06
0.07
1.4
1.2
—
—
—
0
0
13
118
1.10
0.07
2.6
1.5
—
—
—
0
0
13
118
1.10
0.07
2.6
1.5
—
—
—
0
0
13
118
1.10
0.07
2.6
1.5
—
—
—
0
0
13
118
1.10
0.07
2.6
1.5
—
—
—
0
0
28
265
1.06
0.07
2.5
4.2
1.4
1.4
mmol/l
0.13
28
259
9
88
1.02
0.07
1.3
1.1
—
—
—
0
0
8
92
0.87
0.06
3.3
1.9
—
—
—
0
0
16
173
0.92
0.06
2.1
1.7
—
—
—
0
0
12
109
1.10
0.06
1.0
1.3
—
—
nmol/l
—
0
0
98
1001
0.98
0.06
1.9
2.3
—
—
—
0
0
10
90
1.11
0.05
1.2
1.5
11.8
10.9
umol/l
—
10
85
27
257
1.05
0.05
3.1
3.0
—
—
—
0
0
11
120
0.92
0.05
3.9
1.9
—
—
—
0
0
10
109
0.92
0.04
1.2
1.1
—
—
—
0
0
116
1144
1.02
0.04
1.2
1.2
—
—
—
0
0
21
200
1.05
0.03
4.0
3.4
1.7
2.4
mmol/l
0.71
15
125
26
250
1.04
0.03
1.4
1.4
60.4
129.6
pmol/l
0.79
26
242
34
350
0.97
0.03
1.6
1.3
471.1
226.2
u/ml
1.32
19
202
106
1069
0.99
0.01
1.9
2.2
—
—
—
0
0
107
1062
1.01
0.01
1.8
2.1
—
—
—
0
0
75
743
1.01
0.01
2.1
1.6
—
—
—
0
0
29
284
1.02
0.00
1.3
1.1
—
—
—
0
0
67
676
0.99
0.00
1.5
1.4
—
—
—
0
0
18
176
1.02
0.00
1.2
1.3
—
—
—
0
0
21
214
0.98
0.00
1.8
1.6
—
—
—
0
0
12
121
0.99
0.00
1.2
1.3
—
0.6
—
0
5
51
508
1.00
0.00
1.6
1.5
—
—
—
0
0
52
518
1.00
0.00
1.7
1.5
—
—
—
0
0
22
221
1.00
0.00
1.5
1.1
—
—
—
0
0
108
1078
1.00
0.00
1.8
2.2
—
—
—
0
0
108
1081
1.00
0.00
1.8
2.2
—
—
—
0
0
10
97
1.03
0.00
2.2
3.9
—
—
—
0
0
23
227
1.01
0.00
1.7
1.9
—
—
—
0
0
51
507
1.01
0.00
1.6
1.4
—
—
—
0
0
29
285
1.02
0.00
1.3
1.1
—
—
—
0
0
84
835
1.01
0.00
3.0
2.5
0.2
0.2
g/l
0.67
74
784
0
8
0.00
0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
4.4
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
18.3
—
0
8
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
9
90
1.00
0.00
1.3
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
40.4
—
0
7
5
54
0.93
0.00
1.4
1.1
—
—
—
0
0
8
84
0.95
0.00
1.4
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
8
82
0.98
0.00
2.0
1.3
—
70.5
—
0
6
7
69
1.01
0.00
4.9
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
0.00
3.1
1.7
6.0
6.1
mmol/l
—
7
54
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
188.6
—
0
7
7
74
0.95
0.00
1.6
1.3
—
—
—
0
0
7
70
1.00
0.00
2.6
2.5
117.6
143.2
nmol/l
—
7
61
7
69
1.01
0.00
9.7
5.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
51
0.98
0.00
5.8
7.7
—
—
—
0
0
6
68
0.88
0.00
1.2
1.1
—
—
—
0
0
5
55
0.91
0.00
1.2
1.7
—
1993.3
—
0
10
0
9
0.00
0.00
0.0
5.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_JUVOSTEOCHONRHIP and mortality.

Females

Parameter HR [95% CI] p-value
M13_JUVOSTEOCHONRHIP 1.541 [1.25, 1.9] < 0.001
Birth year 0.991 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 5170 females with M13_JUVOSTEOCHONRHIP died.

Males

Parameter HR [95% CI] p-value
M13_JUVOSTEOCHONRHIP 1.025 [0.85, 1.23] 0.794
Birth year 0.99 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 6552 males with M13_JUVOSTEOCHONRHIP died.

Mortality risk

Mortality risk for people of age

years, who have M13_JUVOSTEOCHONRHIP.

N-year risk Females Males
1 0.154% 0.218%
5 0.888% 1.206%
10 2.037% 3.102%
15 3.735% 6.01%
20 6.754% 10.274%

Relationships between endpoints

Index endpoint: M13_JUVOSTEOCHONRHIP – Juvenile osteochondrosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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