Varicella [chickenpox]

AB1_VARICELLA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B01
  • Hospital discharge: ICD-9 05[2]
  • Hospital discharge: ICD-8 05[2]
  • Cause of death: ICD-10 B01
  • Cause of death: ICD-9 05[2]
  • Cause of death: ICD-8 05[2]

2 out of 7 registries used, show all original rules.

1938

4. Check minimum number of events

None

1938

5. Include endpoints

None

1938

6. Filter based on genotype QC (FinnGen only)

1869

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_SKIN_MUCOUS_MEMBRANE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24317 7662 16552
Only index persons 20463 6106 14357
Unadjusted period prevalence (%)
Whole population 0.38 0.22 0.46
Only index persons 0.45 0.22 0.55
Median age at first event (years)
Whole population 15.07 5.26 19.52
Only index persons 15.83 6.61 19.75

-FinnGen-

Key figures

All Female Male
Number of individuals 1869 612 1257
Unadjusted period prevalence (%) 0.46 0.22 0.58
Median age at first event (years) 17.50 11.91 20.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1938
Matched controls
19380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B01.9
ICD-10 Finland
Varicella without complication
478.4
307.7
524
15
05209
ICD-8 Finland
Chickenpox, Unspecified
+∞
307.7
629
*
0529X
ICD-9 Finland
Chickenpox, Varicella without mention of complication
+∞
273.6
256
*
05200
ICD-8 Finland
Chickenpox, Cum meningoencephalitide
+∞
135.0
128
*
B01.8
ICD-10 Finland
Varicella with other complications
887.1
87.4
85
*
05201
ICD-8 Finland
Chickenpox, Cum complicatione alia
+∞
58.6
56
*
05207
ICD-8 Finland
Chickenpox, Suspectae
+∞
56.5
54
*
J05AB01
ATC
aciclovir; systemic
2.5
53.2
419
1944
L04AA01
ATC
[U] ciclosporin
10.3
49.7
56
56
G05.1*B01.1
ICD-10 Finland
Varicella encephalitis
+∞
43.9
42
*
J05AB11
ATC
valaciclovir; oral
2.6
43.7
278
1157
0528X
ICD-9 Finland
Chickenpox, With unspecified complication
+∞
37.6
36
*
127
Kela drug reimbursment
Transplant complication
5.4
35.2
70
133
H02AB09
ATC
hydrocortisone; systemic
4.6
35.0
85
192
L04AD01
ATC
ciclosporin; systemic
5.3
34.7
70
135
0527A
ICD-9 Finland
Chickenpox, With other specified complications
+∞
29.2
28
*
B01AF, ,
ICD-10 Finland
+∞
29.2
28
*
L04AX01
ATC
azathioprine; systemic
3.3
28.3
110
347
G02.0*B01.0
ICD-10 Finland
Varicella meningitis
+∞
28.2
27
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
8.8
26.3
33
38
L04AA06
ATC
mycophenolic acid; systemic
4.4
24.9
62
143
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.5
24.1
86
257
XW000
NOMESCO Finland
Bone marrow biopsy
3.4
22.1
81
246
R50.9
ICD-10 Finland
Fever, unspecified
1.9
22.1
302
1693
B03XA01
ATC
erythropoietin; parenteral
7.9
21.3
29
37
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.1
20.7
56
138
Z94.0
ICD-10 Finland
Kidney transplant status
4.8
19.7
44
93
B02.9
ICD-10 Finland
Zoster without complication
3.2
19.4
78
251
602
Kela drug reimbursment
Children's severe malnutrition
6.4
19.3
32
51
A11CC03
ATC
alfacalcidol; systemic
3.8
18.4
55
146
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.7
17.8
95
359
05699
ICD-8 Finland
Rubella, Non definita
+∞
17.7
17
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
17.5
127
557
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.5
17.2
60
177
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.9
17.0
50
131
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.2
17.0
45
109
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
16.7
704
5274
B07.9
ICD-10 Finland
Verruca simplex
3.3
16.3
62
193
ZX120
NOMESCO Finland
Intravenous
2.1
15.7
155
770
9835/3-C42.1
ICD-O-3
Precursor cell lymphoblastic leukemia, NOS, of bone marrow
26.5
15.6
21
8
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
15.5
347
2233
H26.2
ICD-10 Finland
Complicated cataract
5.3
15.1
30
57
H02AB04
ATC
methylprednisolone; systemic
1.9
15.0
208
1164
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
14.7
148
741
J17.1*B01.2
ICD-10 Finland
Varicella pneumonia
+∞
14.6
14
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
14.5
156
800
XF602
NOMESCO Finland
Bloodpressure monitoring
5.2
14.4
29
56
L03AA02
ATC
filgrastim; parenteral
3.3
14.3
53
163
H02AB06
ATC
prednisolone; systemic
1.5
14.2
751
5840
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
13.5
14.2
24
18
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
5.9
14.0
25
43
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
13.9
339
2226
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.6
13.9
83
333
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
13.8
235
1400
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
5.2
13.6
28
55
A04AA01
ATC
ondansetron; systemic, rectal
2.2
13.5
115
539
L01BA01
ATC
methotrexate; systemic
3.0
13.5
58
195
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
13.3
345
2297
WX882
NOMESCO Finland
High dependency care
2.7
12.8
69
263
BE00A, ,
NOMESCO Finland
70.3
12.6
14
*
05697
ICD-8 Finland
Rubella, Suspecta
+∞
12.5
12
*
0520B
ICD-9 Finland
Chickenpox, Postvaricella encephalitis[VARICELLA CUM PNEUMONITIDE]
+∞
12.5
12
*
B01AB, ,
ICD-10 Finland
+∞
12.5
12
*
ZXD05
NOMESCO Finland
Urgent procedure
1.5
12.1
495
3636
B00.19
ICD-10 Finland
Other vesicular dermatitis caused by the herper simplex virus
26.9
12.0
16
6
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.3
12.0
94
426
Z3231
NOMESCO Finland
Registered nurse
1.5
11.9
458
3322
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.8
11.9
36
97
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
11.8
252
1595
R11
ICD-10 Finland
Nausea and vomiting
1.9
11.8
142
758
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.3
11.7
44
137
Z85.6
ICD-10 Finland
Personal history of leukaemia
30.2
11.6
15
5
B01.0
ICD-10 Finland
Varicella meningitis
+∞
11.5
11
*
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
11.5
136
723
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
4.4
11.2
28
65
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.7
11.2
60
228
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
8.6
11.0
23
27
A12AA04
ATC
calcium carbonate; oral
3.6
10.9
35
98
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
3.5
10.9
36
103
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.3
10.9
81
360
A07AA02
ATC
nystatin; oral
2.4
10.8
70
292
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
10.8
283
1884
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
10.6
329
2276
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
10.5
144
802
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.8
10.5
31
82
137
Kela drug reimbursment
Uraemia requiring dialysis
4.3
10.3
26
61
C90.0
ICD-10 Finland
Multiple myeloma
7.5
10.2
23
31
46599
ICD-8 Finland
Acute upper respiratory infection of multiple or unspecified sites
1.7
10.1
199
1232
S01AD03
ATC
aciclovir; ophthalmic
3.1
10.1
42
139
B05DB
ATC
Hypertonic solutions
4.8
10.0
22
46
C03CA01
ATC
furosemide; systemic
1.6
9.9
265
1772
L04AD02
ATC
tacrolimus; systemic
3.4
9.9
34
100
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
4.3
9.8
25
59
B05DA
ATC
Isotonic solutions
4.4
9.8
24
55
A41.9
ICD-10 Finland
Sepsis, unspecified
2.7
9.8
53
203
TAB00
NOMESCO Finland
Lumbar puncture
2.1
9.7
88
425
TK800
NOMESCO Finland
Hemodialysis
2.8
9.5
46
166
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.9
9.4
118
639
0520A
ICD-9 Finland
Chickenpox, Postvaricella encephalitis[ENCEPHALITIS POST VARICELLAM]
+∞
9.4
9
*
05299, ,
ICD-8 Finland
+∞
9.4
9
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
9.4
157
930
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
12.4
9.4
16
13
Z2446
NOMESCO Finland
Social worker
1.8
9.3
139
796
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.1
9.1
85
415
ZXE00
NOMESCO Finland
One hour or less
1.4
9.1
601
4775
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.1
8.8
84
413
J01DA01
ATC
[U] cefalexin
1.3
8.8
995
8559
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
8.8
306
2163
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.8
8.8
42
151
N18.8
ICD-10 Finland
Other chronic renal failure
3.1
8.7
35
114
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
3.2
8.7
34
109
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.0
8.6
94
486
N05BA09
ATC
clobazam; oral
4.0
8.6
24
61
B03XA02
ATC
darbepoetin alfa; parenteral
3.1
8.4
33
106
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
7.9
8.4
18
23
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
6.7
8.4
20
30
B01.1
ICD-10 Finland
Varicella encephalitis
+∞
8.3
8
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.8
8.3
39
139
Z3226
NOMESCO Finland
Physiotherapist
1.5
8.2
276
1935
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
8.2
173
1090
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
8.2
229
1543
J02AC01
ATC
fluconazole; systemic
1.4
8.2
481
3739
J01MA12
ATC
levofloxacin; systemic
1.5
8.1
242
1654
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.0
8.1
81
407
A05AA02
ATC
ursodeoxycholic acid; oral
2.9
8.0
36
125
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
7.9
261
1825
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
7.9
117
670
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
7.8
595
4807
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
8.5
7.8
16
19
J01DA06
ATC
[U] cefuroxime
1.6
7.8
210
1405
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
45.2
7.7
9
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
7.7
377
2837
JN6AD
NOMESCO Finland
CT of torso and neck
3.2
7.7
29
91
J01DB01
ATC
cefalexin; oral
1.4
7.7
1490
13726
ZX108
NOMESCO Finland
Inhalation
4.5
7.6
18
40
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
7.6
279
1989
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.6
7.6
176
1137
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
7.5
512
4065
Z94.4
ICD-10 Finland
Liver transplant status
7.1
7.5
17
24
R06AE07
ATC
cetirizine; oral
1.3
7.5
695
5773
W19
ICD-10 Finland
Unspecified fall
1.6
7.5
155
974
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
2.0
7.4
74
371
N05BB01
ATC
hydroxyzine; systemic
1.9
7.4
92
498
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
7.4
424
3274
M04AA01
ATC
allopurinol; systemic
1.6
7.4
154
969
WW500
NOMESCO Finland
Blood transfusion
2.2
7.4
57
259
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
7.3
367
2772
05599
ICD-8 Finland
Measles, Non definita
+∞
7.3
7
*
7101
FHL
Needle biopsy in the operating room
+∞
7.3
7
*
153
Kela drug reimbursment
Lenalidomid
9.4
7.3
14
15
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.1
7.3
63
300
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
7.3
400
3069
A87.9
ICD-10 Finland
Viral meningitis, unspecified
4.3
7.2
18
42
ZX121
NOMESCO Finland
Central venous catheter
5.8
7.2
19
33
ZXA10
NOMESCO Finland
Bilateral
1.5
7.2
227
1571
Z49.2
ICD-10 Finland
Other dialysis
4.0
7.2
20
51
N99
ICPC
Neurological disease other
4.0
7.2
20
51
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.6
7.2
150
945
L04AX03
ATC
methotrexate; systemic
1.7
7.1
142
883
H26.3
ICD-10 Finland
Drug-induced cataract
6.0
7.1
18
30
M05BA04
ATC
alendronic acid; oral
2.1
7.0
60
284
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.2
7.0
26
81
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
3.4
7.0
24
71
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
13.8
6.9
11
8
D70.89
ICD-10 Finland
Neutropenic splenomegaly
3.4
6.8
24
72
L08.0
ICD-10 Finland
Pyoderma
4.1
6.8
18
44
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
6.7
6.8
16
24
XF600
NOMESCO Finland
Bloodpressure measurement
1.8
6.8
102
587
L04AX04
ATC
lenalidomide; oral
9.3
6.8
13
14
A10AB01
ATC
insulin (human); parenteral
2.1
6.8
65
322
R4110
NOMESCO Finland
Physiotherapy
1.4
6.8
398
3083
B01AB05
ATC
enoxaparin; parenteral
1.4
6.7
381
2933
TGC00
NOMESCO Finland
Bronchial lavation
2.6
6.7
38
150
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
3.4
6.7
23
68
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
3.4
6.7
23
68
ZXD00
NOMESCO Finland
Emergency procedure
2.3
6.6
50
225
J03.9
ICD-10 Finland
Acute tonsillitis, unspecified
1.7
6.6
111
659
A10AA01, ,
ATC
2.2
6.6
52
238
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
6.6
930
8122
J01FF01
ATC
clindamycin; systemic
1.4
6.5
410
3206
S18
ICPC
Laceration/cut
1.3
6.5
665
5568
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.8
6.5
87
483
B34.9
ICD-10 Finland
Viral infection, unspecified
2.0
6.5
64
320
3AC01, ,
NOMESCO Finland
3.7
6.5
20
55
A10AA02, ,
ATC
2.2
6.4
54
254
AA1AD
NOMESCO Finland
CT of head and brain
1.4
6.4
326
2462
J45.1
ICD-10 Finland
Nonallergic asthma
1.7
6.4
107
634
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
6.4
228
1615
5639
FHL
Other measure in this category
70.1
6.4
7
*
L20.0
ICD-10 Finland
Besnier prurigo
1.6
6.4
146
941
K06.18
ICD-10 Finland
Another gingival hyperplasia
6.6
6.3
15
23
TPX10
NOMESCO Finland
Implantation of vascular injection port
2.2
6.3
48
217
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
6.3
424
3349
JN4AD
NOMESCO Finland
Body CT examination
1.7
6.3
118
723
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
18.1
6.3
9
5
G43.9
ICD-10 Finland
Migraine, unspecified
1.8
6.3
95
549
B01AA, ,
ICD-10 Finland
+∞
6.3
6
*
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
+∞
6.3
6
*
7143D
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[OLIGARTHRITIS JUVENILIS]
26.8
6.2
8
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
1.9
6.2
72
382
B01AA03
ATC
warfarin; systemic
1.5
6.2
166
1109
E0000UV, ,
ATC
1.3
6.2
631
5276
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
5.0
6.2
18
36
L04AA13
ATC
[U] leflunomide
2.6
6.1
33
127
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
3.0
6.1
25
83
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.4
6.1
39
164
N18.0
ICD-10 Finland
End-stage renal disease
3.6
6.0
19
53
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
2.5
6.0
36
146
XX3DW
NOMESCO Finland
Time consuming IT work
1.6
6.0
128
810

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
87
5.75
26.53
36.6
26.0
95.91
133.92
ug/l
2.91
44
65
333
1886
1.92
23.71
12.5
7.5
1.06
1.07
mmol/l
0.24
324
1788
753
5541
1.59
20.34
7.2
5.5
36.21
36.67
g/l
1.33
717
5217
221
1164
2.01
19.22
10.4
4.6
4.82
4.81
kpa
0.02
216
1134
247
1372
1.92
18.38
11.3
5.2
1.24
1.73
mmol/l
1.77
216
1142
247
1375
1.91
18.25
11.3
5.2
5.77
5.86
kpa
0.92
241
1341
992
7917
1.52
17.75
10.5
6.4
1.93
2.02
e9/l
1.14
909
7078
216
1161
1.97
17.69
5.8
4.6
0.61
0.95
%
2.34
82
396
962
7633
1.52
17.67
10.5
6.4
0.04
0.04
e9/l
0.05
864
6666
207
1098
1.99
17.60
5.7
4.7
0.04
0.11
%
1.75
73
332
1064
8631
1.52
17.53
14.2
9.3
3.91
4.02
e9/l
0.88
955
7530
960
7633
1.51
17.33
10.5
6.4
0.58
0.58
e9/l
0.21
865
6668
887
6948
1.51
17.13
11.1
6.7
0.68
0.68
%
0.05
839
6568
350
2210
1.71
16.94
7.4
4.6
0.80
0.82
mmol/l
1.98
332
2105
290
1743
1.78
16.69
2.0
1.7
—
—
—
0
0
496
3437
1.60
16.62
6.0
4.3
—
—
—
0
0
982
7895
1.49
16.47
11.3
6.8
0.19
0.20
e9/l
0.33
894
6994
197
1053
1.97
16.36
5.6
4.7
0.13
0.72
%
0.80
60
279
911
7229
1.49
16.21
11.4
6.9
8.72
8.57
%
0.81
866
6860
905
7175
1.49
16.15
11.0
6.6
2.95
2.92
%
0.13
856
6794
59
180
3.35
16.06
2.4
2.5
35.74
38.14
%
0.52
59
180
939
7519
1.48
15.83
11.0
6.5
29.58
29.33
%
0.28
893
7155
927
7406
1.48
15.80
10.4
6.3
55.28
55.87
%
0.76
881
7044
178
930
2.01
15.76
4.4
3.2
72.34
71.83
e9/l
0.06
137
699
402
2685
1.63
15.56
4.5
2.7
556.25
580.14
mosm/kgh2o
1.23
370
2317
710
5402
1.50
15.28
3.1
2.3
72.16
71.83
nmol/l
0.11
661
5010
29
53
5.54
15.26
3.3
2.9
—
—
—
0
0
809
6325
1.48
15.17
13.0
7.5
1.21
1.21
mmol/l
0.56
699
5476
41
105
3.97
14.43
32.9
37.1
6.56
7.54
ug/l
1.70
32
97
1027
8462
1.45
14.40
8.1
5.0
6.75
6.67
mmol/l
0.42
974
7860
217
1252
1.83
14.22
4.7
2.5
9.88
10.40
g/l
0.83
193
1152
68
244
2.85
14.09
4.5
3.5
—
—
—
0
0
193
1078
1.88
14.01
5.1
4.3
0.26
0.66
%
4.90
64
348
159
833
1.99
13.96
8.2
4.8
96.67
82.42
ng/l
1.17
151
761
83
335
2.54
13.69
1.9
1.9
—
—
—
0
0
55
178
3.15
13.64
2.4
2.8
1.23
1.24
e9/l
0.02
45
156
223
1314
1.79
13.61
6.6
3.4
1.78
1.71
%
0.38
207
1204
894
7231
1.44
13.52
11.9
6.9
—
—
—
0
0
315
2059
1.63
13.11
4.3
2.5
13.78
14.41
umol/l
0.74
301
1947
26
28
9.40
12.97
2.0
2.1
—
—
—
0
0
850
6860
1.43
12.76
14.9
9.1
0.01
0.00
e9/l
0.53
728
5627
864
7012
1.42
12.48
9.4
6.4
12.01
11.89
umol/l
0.07
826
6662
40
112
3.63
12.45
2.8
2.4
—
—
—
0
0
43
127
3.44
12.36
1.6
1.9
—
—
—
0
0
27
57
4.79
12.14
1.4
1.2
—
—
—
0
0
734
5818
1.42
11.96
12.2
10.3
1.15
1.18
inr
0.79
245
1744
273
1783
1.62
11.31
4.6
2.6
23.64
24.38
%
0.34
244
1586
50
172
2.96
11.22
2.2
2.1
—
—
—
0
0
718
5726
1.40
11.07
13.1
7.0
1.21
1.21
mmol/l
0.47
680
5318
82
366
2.30
10.90
1.9
1.9
70.97
7.00
e6/l
1.78
63
286
315
2152
1.55
10.74
3.4
2.6
29.76
29.72
s
0.04
306
2091
499
3758
1.44
10.52
5.1
3.0
0.31
0.41
e6/l
0.58
410
2834
81
366
2.27
10.47
1.9
1.9
1366.38
1156.70
e6/l
0.07
65
298
208
1293
1.68
10.43
16.9
10.6
—
—
—
0
0
30
78
3.89
10.40
2.2
2.5
147.65
247.71
e6/l
1.10
17
48
1245
10947
1.38
10.25
11.0
7.1
82.06
78.83
u/l
1.24
1197
10405
554
4280
1.41
10.06
3.6
2.4
—
—
—
0
0
386
2792
1.48
9.98
4.1
2.6
5.27
5.03
e6/l
0.10
357
2506
314
2182
1.52
9.85
1.9
1.7
—
—
—
0
0
494
3755
1.42
9.79
10.9
7.2
—
—
—
0
0
476
3596
1.43
9.76
8.6
4.2
7.40
7.40
ph
0.02
107
718
151
875
1.79
9.72
5.3
2.5
66.01
67.16
g/l
0.94
142
821
72
321
2.29
9.63
4.8
3.9
56.60
55.33
%
0.38
72
321
36
113
3.23
9.47
2.7
2.9
31.66
41.52
%
2.01
11
54
41
140
2.97
9.37
2.2
3.0
0.19
0.21
e9/l
0.19
31
118
461
3487
1.42
9.33
4.1
3.1
—
—
—
0
0
46
168
2.78
9.32
2.6
1.8
—
—
—
0
0
219
1420
1.61
9.29
1.7
1.5
—
—
—
0
0
64
277
2.36
9.17
1.3
1.2
—
—
—
0
0
69
309
2.28
9.14
4.0
3.7
3.68
4.00
e9/l
0.72
69
309
41
143
2.91
9.04
2.1
3.0
580.48
566.36
e6/l
0.04
31
119
46
171
2.73
9.02
2.4
2.6
—
—
—
0
0
279
1928
1.52
8.94
4.5
2.5
2.33
2.39
g/l
1.01
264
1807
528
4119
1.39
8.87
5.3
3.1
58.43
92.68
e6/l
0.47
435
3156
567
4480
1.38
8.80
4.1
3.3
8.53
8.86
mmol/l
0.80
500
3934
494
3817
1.39
8.77
7.2
4.3
91.46
91.51
%
0.02
483
3733
131
756
1.79
8.57
1.8
1.5
4.93
6.45
u/l
2.71
109
596
504
3941
1.38
8.26
4.0
2.5
1533.97
3580.31
umol/l
1.32
466
3609
513
4034
1.37
8.09
3.6
3.3
2.34
2.35
mmol/l
0.77
470
3666
161
1002
1.66
8.04
1.7
1.4
—
—
—
0
0
415
3158
1.40
7.97
2.7
2.2
2.89
2.80
mg/l
0.37
368
2754
49
201
2.48
7.93
5.9
3.9
0.72
1.18
%
1.53
44
187
441
3395
1.39
7.90
1.9
1.5
2.14
2.39
g/l
1.96
292
2141
199
1313
1.57
7.83
3.3
2.8
0.22
0.22
g/l
0.18
180
1235
398
3017
1.40
7.80
4.2
3.0
1217.90
1059.59
ng/l
0.36
328
2468
505
3982
1.36
7.78
4.7
3.9
12.56
10.00
mg/mmol
0.59
354
2764
154
957
1.66
7.74
7.7
4.2
1.22
1.23
mmol/l
1.25
142
848
93
498
1.91
7.74
2.8
2.0
1.39
1.42
g/l
0.08
84
429
77
387
2.03
7.68
1.9
1.6
119.30
114.22
u/ml
—
10
68
46
189
2.47
7.44
2.9
1.6
—
—
—
0
0
79
408
1.98
7.32
1.9
1.6
—
—
—
0
0
396
3031
1.39
7.29
3.7
2.5
—
—
—
0
0
155
982
1.63
7.23
3.2
1.7
1.37
1.33
g/l
0.05
142
914
96
532
1.85
7.20
5.2
2.7
—
—
—
0
0
1198
10739
1.30
7.15
5.4
3.7
10.07
9.15
mm/h
1.60
1133
10086
583
4747
1.33
7.15
2.0
1.8
94.17
95.94
pmol/l
0.42
338
2672
295
2152
1.44
7.14
2.4
2.3
13.21
13.72
nmol/l
0.58
278
2003
164
1057
1.60
7.13
5.8
4.3
5.07
5.14
kpa
0.58
156
1012
296
2161
1.44
7.13
4.4
2.8
2.52
1.62
e6/l
0.74
177
1152
115
676
1.75
7.10
5.6
2.0
—
—
—
0
0
538
4334
1.33
7.10
3.2
2.7
59.00
61.20
u/l
0.42
506
4071
592
4841
1.32
7.02
5.9
3.6
53.94
66.55
e6/l
0.27
457
3391
162
1046
1.60
7.00
5.8
4.3
7.41
7.41
ph
0.02
23
106
17
39
4.39
6.96
1.9
1.6
—
—
—
0
0
478
3802
1.34
6.84
4.2
3.3
434.97
390.14
mg/l
0.08
326
2660
258
1850
1.46
6.83
1.8
1.6
1105.20
1126.46
nmol/l
0.14
213
1453
305
2258
1.42
6.79
4.4
2.7
1.19
0.84
e6/l
0.44
192
1244
35
132
2.68
6.75
1.5
1.4
—
—
—
0
0
205
1409
1.51
6.71
2.8
2.3
359.65
364.54
nmol/l
0.14
196
1325
495
3969
1.33
6.68
2.5
2.2
232.31
266.72
u/l
0.25
476
3778
91
509
1.83
6.65
5.2
4.3
0.18
0.26
g/l
1.46
58
288
159
1035
1.58
6.64
2.3
2.3
9.58
19.73
au/ml
3.01
13
93
274
1998
1.43
6.63
2.3
2.2
—
—
—
0
0
28
95
2.98
6.54
5.1
2.0
—
—
—
0
0
602
4975
1.30
6.52
3.9
3.0
54.06
46.24
ng/l
0.21
421
3009
147
952
1.59
6.29
1.3
1.3
40.98
53.23
au/ml
—
6
50
744
6361
1.28
6.09
4.1
2.8
158.54
127.28
ug/l
0.80
697
6012
25
83
3.04
6.08
3.9
3.2
1178.20
704.29
u/ml
0.72
25
83
73
393
1.89
6.04
1.3
1.3
—
—
—
0
0
280
2086
1.40
5.99
1.5
1.3
540.36
461.55
titre
0.24
55
362
1671
15844
1.40
5.95
20.3
12.9
3.98
3.97
mmol/l
0.41
1644
15441
629
5281
1.28
5.92
4.8
3.4
49.65
36.48
u/l
0.37
602
5012
127
810
1.61
5.80
5.7
4.6
—
—
—
0
0
130
834
1.60
5.80
1.4
1.2
—
—
—
0
0
34
137
2.51
5.79
2.1
1.4
0.91
1.03
g/l
1.22
34
137
79
443
1.82
5.77
1.6
1.3
304.52
238.27
u/ml
0.79
50
251
20
61
3.30
5.58
1.6
1.6
—
—
—
0
0
60
311
1.96
5.58
4.9
4.7
2.00
2.42
mmol/l
0.95
42
197
34
140
2.45
5.55
3.2
2.8
1.12
2.18
g/24h
1.10
17
80
461
3746
1.30
5.53
5.3
3.0
—
—
—
0
0
70
385
1.85
5.45
3.4
2.8
—
—
—
0
0
276
2086
1.38
5.40
2.9
2.8
148.67
135.76
ug/g
0.22
238
1714
1659
15763
1.36
5.38
20.0
12.8
139.65
139.62
mmol/l
0.17
1633
15387
192
1373
1.44
5.16
3.0
2.7
35.73
75.65
u/l
0.62
176
1201
104
652
1.63
5.13
4.6
3.1
21.54
21.58
s
0.03
94
578
48
237
2.05
5.12
10.2
3.1
—
—
—
0
0
410
3310
1.30
5.12
3.4
2.4
—
—
—
0
0
16
45
3.58
5.05
3.6
1.8
—
—
—
0
0
1220
11184
1.25
5.04
3.9
3.4
14.67
14.55
pmol/l
1.01
1148
10364
77
448
1.75
5.01
2.3
2.1
3.64
1.40
ug/l
0.86
70
412
25
94
2.68
4.92
5.3
3.1
—
—
—
0
0
26
100
2.62
4.90
1.9
1.6
—
—
—
0
0
29
118
2.48
4.88
5.0
2.8
—
—
—
0
0
1082
9810
1.23
4.87
5.4
3.6
—
—
—
0
0
84
506
1.69
4.84
1.4
1.1
—
—
—
0
0
46
230
2.02
4.77
5.6
4.2
—
—
—
0
0
451
3718
1.28
4.76
2.1
2.0
—
—
—
0
0
146
1009
1.48
4.69
1.2
1.2
167.61
148.68
iu/ml
0.25
55
378
363
2917
1.30
4.66
1.9
1.7
—
—
—
0
0
110
717
1.57
4.64
1.7
1.5
13.88
19.56
iu/l
1.43
85
573
89
553
1.64
4.58
2.2
2.2
—
—
—
0
0
76
454
1.70
4.54
2.2
1.4
0.23
0.24
g/l
0.68
70
429
1659
15847
1.33
4.51
18.9
11.6
21.36
22.86
mg/l
1.15
1351
12185
1261
11678
1.23
4.40
4.1
3.2
51.36
49.59
u/l
0.30
1207
11165
18
60
3.02
4.40
2.8
1.9
—
—
—
0
0
802
7100
1.22
4.39
4.3
3.0
0.00
0.00
estimate
0.80
187
1418
316
2514
1.31
4.36
1.7
1.5
19.28
20.24
nmol/l
0.52
277
2216
55
303
1.84
4.33
10.9
3.1
46.51
33.45
mg/l
0.71
42
238
55
303
1.84
4.33
10.9
3.1
68.98
75.42
mg/l
0.08
42
239
22
83
2.67
4.32
4.0
2.4
1.66
1.83
umol/l
0.51
22
77
69
410
1.71
4.22
2.8
2.3
10.31
10.58
mg/l
0.09
64
385
31
140
2.23
4.19
2.9
3.4
—
—
—
0
0
111
744
1.52
4.16
1.6
1.3
—
—
—
0
0
757
6690
1.22
4.15
3.4
2.5
—
—
—
0
0
54
302
1.81
4.07
10.8
3.0
27.54
3.11
ratio
—
5
38
15
47
3.21
4.06
9.6
5.7
26.51
48.13
g/mol
0.59
15
41
797
7095
1.21
4.02
6.1
4.1
0.00
0.00
estimate
0.50
179
1392
29
130
2.25
4.00
1.6
2.2
—
—
—
0
0
221
1693
1.34
3.97
1.8
1.5
—
—
—
0
0
24
100
2.42
3.89
1.1
1.3
—
—
—
0
0
67
406
1.67
3.84
1.5
1.4
260.46
284.85
ug/g
0.42
35
237
1457
13777
1.23
3.80
4.5
3.9
1.91
2.34
mu/l
0.91
1380
12892
395
3297
1.25
3.68
2.5
2.0
1.35
1.02
mg/l
0.51
311
2465
799
7161
1.20
3.64
4.2
3.0
0.03
0.01
estimate
0.63
173
1300
484
4145
1.22
3.53
3.8
2.7
—
—
—
0
0
35
179
1.97
3.49
1.9
3.5
—
—
—
0
0
42
229
1.85
3.47
4.8
3.5
—
—
—
0
0
31
152
2.06
3.46
6.7
4.6
—
—
—
0
0
223
1747
1.31
3.45
6.5
3.1
9.33
8.05
umol/l
0.31
193
1519
300
2443
1.27
3.44
1.6
1.6
33591172.66
40236268.59
pmol/l
0.07
259
2120
147
1081
1.39
3.44
1.5
1.3
407.45
240.10
u/ml
0.63
136
1002
14
47
2.99
3.41
1.1
1.2
—
—
—
0
0
80
523
1.55
3.41
1.2
1.2
—
—
—
0
0
1749
16949
1.33
3.39
20.1
12.8
80.15
76.79
umol/l
2.90
1749
16942
19
76
2.51
3.38
1.2
1.1
1695.74
1457.30
miu/ml
0.31
19
76
9
18
5.02
3.37
1.0
1.1
—
—
—
0
0
20
83
2.42
3.30
1.1
1.1
—
—
—
0
0
20
83
2.42
3.30
5.8
4.7
—
—
—
0
0
40
219
1.84
3.28
1.7
1.5
0.48
0.30
nmol/l
0.43
33
181
48
279
1.74
3.24
3.7
2.5
16.78
17.26
%
0.29
27
148
20
84
2.40
3.23
1.8
1.7
—
—
—
0
0
20
84
2.40
3.23
1.1
1.0
—
—
—
0
0
17
66
2.59
3.21
3.8
3.8
202.09
161.35
umol/l
0.22
11
36
22
97
2.28
3.20
4.0
4.5
8.37
8.74
mg/l
0.11
17
86
50
296
1.71
3.18
1.3
1.7
0.99
0.90
g/l
0.10
35
231
588
5178
1.19
3.17
2.1
1.9
—
—
—
0
0
16
61
2.64
3.13
1.3
1.1
137.71
252.68
ng/l
—
7
16
652
5814
1.18
3.02
4.0
2.8
5.70
5.80
ph
0.42
53
683
119
869
1.39
2.94
3.6
2.9
199.33
136.20
ng/l
1.00
107
769
141
1059
1.36
2.93
4.7
4.1
—
—
—
0
0
157
1199
1.34
2.93
4.2
3.6
—
—
—
0
0
35
192
1.84
2.89
6.0
7.0
9.88
10.46
mg/l
0.33
27
179
52
320
1.64
2.89
5.9
3.6
—
—
—
0
0
958
8838
1.17
2.86
5.0
3.6
52.70
324.99
e6/l
—
10
92
52
323
1.63
2.79
19.2
4.6
—
—
—
0
0
9
23
3.93
2.77
2.0
2.0
—
—
—
0
0
49
303
1.63
2.69
1.1
1.1
—
—
—
0
0
8
19
4.22
2.68
5.9
7.6
4.49
8.47
mmol/l
—
8
19
1746
17004
1.27
2.57
13.6
9.1
30.31
30.55
u/l
0.18
1709
16562
1727
16801
1.26
2.54
15.0
10.6
—
—
—
0
0
11
37
2.98
2.49
2.2
2.2
—
—
—
0
0
428
3737
1.19
2.48
1.4
1.4
1.63
2.38
u/ml
0.77
113
999
180
1439
1.28
2.44
11.7
9.8
0.26
0.89
mmol/l
1.05
140
1165
131
1004
1.33
2.43
3.9
4.6
15.22
25.07
ug/l
0.44
106
807
5
8
6.26
2.37
1.0
1.1
—
—
—
0
0
8
22
3.65
2.36
1.8
2.2
—
—
—
0
0
220
1810
1.24
2.34
1.2
1.2
—
—
—
0
0
165
1312
1.28
2.34
12.1
10.2
95.48
96.01
%
0.48
160
1261
38
229
1.67
2.34
3.5
2.8
9.03
7.85
umol/l
0.19
30
176
17
78
2.19
2.31
1.1
1.2
—
—
—
0
0
123
943
1.32
2.29
4.0
3.0
—
—
—
0
0
16
72
2.23
2.27
3.3
1.6
25.04
7.86
ug/l
0.41
16
64
6
13
4.63
2.27
7.5
5.1
—
—
—
0
0
98
727
1.37
2.26
13.5
13.1
—
—
—
0
0
179
1445
1.26
2.25
11.7
9.7
5.00
5.15
kpa
1.05
170
1381
179
1445
1.26
2.25
11.7
9.7
12.08
12.70
kpa
0.79
169
1384
63
432
1.47
2.25
3.5
3.9
882.88
3419.92
u/ml
0.54
54
378
236
1967
1.23
2.23
2.7
3.0
2.42
2.43
mmol/l
0.52
210
1717
28
157
1.79
2.22
1.4
1.2
—
—
—
0
0
10
35
2.87
2.21
1.1
1.3
—
—
—
0
0
22
114
1.94
2.20
1.0
1.0
—
—
—
0
0
19
94
2.03
2.16
1.4
1.2
—
46.70
—
0
6
20
101
1.99
2.15
1.3
1.2
—
—
—
0
0
10
36
2.79
2.13
2.2
3.1
—
—
—
0
0
1439
13827
1.16
2.13
5.9
4.8
39.90
39.19
mmol/mol
1.78
1368
13161
66
463
1.44
2.12
1.4
1.3
93.33
118.13
titre
—
6
48
12
49
2.46
2.10
4.0
2.4
38.42
101.68
ug/l
2.86
12
49
36
221
1.64
2.09
1.6
1.5
—
—
—
0
0
6
15
4.01
2.04
8.2
4.3
—
—
—
0
0
23
125
1.85
2.02
1.7
1.6
—
—
—
0
0
1465
14122
1.15
1.97
21.7
14.1
14.48
14.25
%
0.92
1445
13877
12
51
2.36
1.95
1.8
1.3
—
—
—
0
0
101
774
1.32
1.93
1.8
1.6
330.80
300.64
mu/l
0.45
94
714
24
136
1.77
1.87
1.7
2.1
32.17
33.15
pg
0.41
24
136
180
1489
1.23
1.86
4.2
3.8
30.46
30.07
%
0.21
140
1114
44
293
1.51
1.85
1.1
1.1
—
—
—
0
0
11
46
2.40
1.85
1.5
2.4
—
—
—
0
0
36
229
1.58
1.85
2.4
2.4
—
—
—
0
0
5
12
4.17
1.82
4.0
2.8
25.20
28.58
umol/l
—
5
12
7
23
3.05
1.80
5.9
5.0
—
—
—
0
0
37
239
1.56
1.79
1.8
1.5
—
—
—
0
0
34
217
1.58
1.74
1.2
1.2
—
—
—
0
0
22
125
1.77
1.72
1.3
1.6
11.89
12.28
umol/l
0.13
22
117
5
13
3.85
1.71
4.0
2.7
38.60
34.62
umol/l
—
5
13
30
187
1.61
1.69
1.3
1.3
—
—
—
0
0
30
187
1.61
1.69
1.2
1.3
6.71
6.59
g/l
0.08
17
133
30
187
1.61
1.69
1.2
1.3
0.26
0.38
g/l
1.40
18
130
30
187
1.61
1.69
1.2
1.3
2.58
2.85
g/l
0.35
18
131
25
149
1.69
1.67
2.4
1.7
—
—
—
0
0
18
97
1.86
1.66
2.8
2.4
64.28
53.98
umol/l
0.62
18
88
10
41
2.45
1.64
1.7
1.3
90.70
88.20
nmol/24h
—
10
41
22
127
1.74
1.64
1.5
1.2
—
—
—
0
0
5
14
3.58
1.61
1.8
1.4
—
—
—
0
0
24
143
1.69
1.61
20.2
5.2
10.97
11.76
%
0.47
24
143
14
70
2.01
1.59
1.1
1.2
—
—
—
0
0
236
2038
1.18
1.58
1.8
1.8
—
—
—
0
0
427
3856
1.14
1.56
1.7
1.7
1.48
1.52
mmol/l
0.33
371
3355
15
78
1.93
1.54
1.1
1.2
—
—
—
0
0
410
3698
1.14
1.53
4.4
3.3
0.01
0.01
estimate
0.05
170
1331
5
15
3.34
1.52
1.4
1.2
—
—
—
0
0
7
27
2.60
1.51
1.3
2.3
—
—
—
0
0
42
291
1.45
1.51
3.0
3.3
24.38
26.80
mg/l
0.19
26
176
219
2524
0.85
1.47
1.4
1.4
—
—
—
0
0
1083
10340
1.11
1.45
3.7
3.2
—
—
—
0
0
30
198
1.52
1.38
1.4
1.4
78.55
73.93
mmol/l
0.21
22
167
5
17
2.95
1.36
6.8
9.9
—
—
—
0
0
5
17
2.95
1.36
2.6
3.9
—
—
—
0
0
19
112
1.70
1.35
1.3
1.2
—
—
—
0
0
56
418
1.35
1.35
1.7
2.1
1.07
0.79
nmol/l
0.97
48
358
12
61
1.97
1.33
2.5
2.6
2.10
1.86
mmol/l
—
7
49
99
802
1.25
1.31
2.9
2.2
—
—
—
0
0
272
2415
1.15
1.30
1.2
1.2
32.70
28.77
iu/ml
0.18
83
788
1505
14659
1.12
1.29
4.2
3.8
5.98
5.90
mmol/l
1.24
1425
13727
8
34
2.36
1.29
1.0
1.4
—
—
—
0
0
19
114
1.67
1.28
3.5
2.7
0.88
0.89
nmol/l
0.03
12
89
19
114
1.67
1.28
2.1
2.7
46168.42
43684.25
ug/l
0.21
19
114
5
19
2.64
1.21
1.0
1.0
—
—
—
0
0
66
514
1.29
1.21
6.3
5.2
—
—
—
0
0
19
116
1.64
1.21
1.9
1.5
39.05
29.98
%
0.44
13
82
14
78
1.80
1.21
1.1
1.2
0.58
2.35
u/ml
—
6
51
20
124
1.62
1.21
2.0
1.4
15404.13
92203.58
e6/l
0.72
15
93
20
124
1.62
1.21
2.9
2.7
—
—
—
0
0
40
289
1.39
1.20
3.5
2.3
131.66
135.47
g/l
0.37
29
216
51
384
1.34
1.19
1.4
1.3
—
—
—
0
0
37
265
1.40
1.17
1.6
1.4
167.88
206.60
pmol/l
0.50
37
265
0
33
0.00
1.16
0.0
7.4
—
—
—
0
0
7
30
2.34
1.12
1.4
1.3
—
—
—
0
0
23
151
1.53
1.11
2.3
1.7
52.35
54.41
%
0.08
17
111
41
302
1.37
1.11
1.2
1.2
2.94
4.79
u/ml
1.01
18
133
1528
14934
1.11
1.10
4.1
3.6
1.40
1.39
mmol/l
0.11
1448
14174
1596
15650
1.11
1.03
4.8
4.3
2.81
2.86
mmol/l
1.33
1522
14871
75
609
1.24
1.02
1.3
1.3
183.61
230.01
miu/ml
0.55
29
278
45
342
1.32
1.02
2.1
1.8
2.90
5.45
iu/l
1.72
14
127
31
222
1.40
1.00
2.0
1.7
—
—
—
0
0
96
802
1.21
1.00
3.6
3.4
4.54
4.68
pmol/l
0.80
90
729
108
913
1.19
0.99
1.2
1.2
149.00
164.14
titre
—
5
28
17
107
1.59
0.99
1.0
1.0
—
—
—
0
0
106
896
1.19
0.98
1.2
1.2
—
—
—
0
0
21
140
1.51
0.97
1.0
1.1
0.88
5.17
u/ml
—
8
53
58
460
1.27
0.97
2.4
2.8
—
—
—
0
0
9
50
1.80
0.96
1.7
1.3
—
—
—
0
0
55
434
1.28
0.96
1.1
1.1
4.49
6.88
u/ml
0.64
30
256
19
125
1.53
0.94
1.8
1.9
—
—
—
0
0
54
428
1.27
0.92
1.2
1.2
—
—
—
0
0
20
134
1.50
0.91
1.0
1.2
0.30
1.91
u/ml
—
9
59
19
126
1.51
0.91
1.2
1.1
—
—
—
0
0
82
979
0.83
0.90
1.4
1.6
—
—
—
0
0
88
739
1.20
0.89
2.1
2.4
11782.98
4168.87
u/l
0.83
36
277
12
72
1.67
0.85
1.9
1.4
—
—
—
0
0
15
96
1.57
0.84
1.9
4.2
0.60
1.73
ug/l
3.57
15
91
43
336
1.29
0.83
1.1
1.1
73.59
112.32
iu/ml
—
7
92
114
987
1.16
0.83
1.6
1.4
—
—
—
0
0
23
163
1.42
0.82
1.5
1.2
—
—
—
0
0
14
89
1.58
0.81
1.4
1.4
—
—
—
0
0
1578
15513
1.09
0.81
4.5
4.0
4.62
4.69
mmol/l
2.43
1512
14817
34
260
1.31
0.78
1.3
1.5
—
—
—
0
0
123
1079
1.15
0.76
1.9
2.1
—
—
—
0
0
19
133
1.43
0.73
1.1
1.1
—
—
—
0
0
5
25
2.00
0.72
1.4
1.3
—
—
—
0
0
57
471
1.22
0.72
1.1
1.1
4.94
7.40
u/ml
0.31
11
82
23
168
1.37
0.71
1.8
1.4
286.94
289.09
mosm/kgh2o
0.19
18
131
506
4797
1.07
0.71
1.6
1.5
—
—
—
0
0
5
26
1.93
0.70
1.0
1.2
—
—
—
0
0
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
11
170
0.65
0.70
10.0
20.5
1278.55
1384.47
nmol/l
0.16
11
165
22
160
1.38
0.70
1.3
1.2
290.00
162.73
titre
—
5
33
36
283
1.28
0.69
1.1
1.1
1.71
3.21
u/ml
0.75
16
136
166
1836
0.90
0.69
1.6
1.6
—
—
—
0
0
11
69
1.60
0.68
1.6
2.0
—
34.27
—
0
9
1569
15454
1.08
0.67
4.5
3.9
1.34
1.36
mmol/l
1.16
1495
14719
1836
18220
1.15
0.66
26.6
17.0
40.87
42.08
%
2.49
1766
17329
5
28
1.79
0.66
1.6
1.1
—
—
—
0
0
121
1075
1.13
0.65
1.9
2.0
—
—
—
0
0
174
1580
1.11
0.65
1.3
1.2
—
—
—
0
0
70
597
1.18
0.65
1.6
1.6
—
—
—
0
0
24
180
1.34
0.65
2.0
1.4
1.86
1.42
promille
0.50
16
142
1838
18244
1.14
0.64
25.7
16.8
7.01
6.69
e9/l
0.55
1807
17794
13
87
1.50
0.63
1.6
1.5
—
—
—
0
0
122
1089
1.13
0.62
1.9
2.1
—
—
—
0
0
6
101
0.59
0.62
3.0
2.7
—
—
—
0
0
1837
18240
1.14
0.60
25.6
16.7
30.27
30.24
pg
0.29
1828
18046
122
1092
1.13
0.60
1.9
2.1
—
—
—
0
0
0
21
0.00
0.60
0.0
11.2
—
—
—
0
0
17
122
1.40
0.60
1.3
1.1
—
—
—
0
0
324
3043
1.08
0.59
4.0
3.1
1.02
1.02
kg/l
0.49
53
435
1837
18242
1.13
0.59
25.6
16.7
90.28
90.05
fl
1.24
1828
18048
11
72
1.53
0.59
1.3
1.7
0.91
3.16
u/field
0.53
11
59
14
97
1.45
0.59
2.0
2.4
1.38
1.42
u/field
—
8
53
243
2257
1.09
0.59
1.2
1.2
10.11
10.43
u/ml
0.02
94
938
27
210
1.29
0.58
1.6
1.4
—
—
—
0
0
1837
18244
1.13
0.58
25.7
16.8
4.63
4.67
e12/l
3.11
1806
17803
92
811
1.14
0.58
4.8
5.9
—
—
—
0
0
1835
18224
1.13
0.57
25.7
16.8
250.38
250.19
e9/l
0.04
1812
17813
50
421
1.19
0.55
1.1
1.1
1.04
1.23
u/ml
0.14
24
221
6
37
1.62
0.55
3.2
2.6
—
—
—
0
0
1837
18249
1.13
0.55
26.0
16.9
139.34
140.75
g/l
3.41
1826
18055
56
480
1.17
0.52
1.1
1.2
3.22
3.41
u/ml
0.04
32
278
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
9
64
1.41
0.51
2.3
1.4
—
—
—
0
0
62
713
0.87
0.51
1.7
1.6
—
—
—
0
0
276
2595
1.07
0.51
4.3
3.5
931.47
703.86
ng/l
0.23
208
1841
64
557
1.15
0.50
1.5
1.7
—
—
—
0
0
95
851
1.12
0.49
1.9
2.1
—
—
—
0
0
148
1360
1.10
0.48
1.2
1.2
—
—
—
0
0
17
128
1.33
0.47
1.6
1.5
85.94
78.08
umol/l
0.39
17
128
80
711
1.13
0.47
2.5
2.8
—
—
—
0
0
244
2292
1.07
0.47
1.7
1.5
—
—
—
0
0
7
48
1.46
0.46
1.9
2.6
—
—
—
0
0
15
111
1.35
0.46
1.1
1.5
1.34
1.80
u/ml
—
7
64
16
120
1.34
0.46
1.0
1.3
1.42
1.49
g/l
0.59
16
120
112
1019
1.11
0.45
1.9
2.1
—
—
—
0
0
10
69
1.45
0.44
1.1
1.2
—
—
—
0
0
10
69
1.45
0.44
1.2
1.4
143.00
151.39
nmol/l
—
10
69
88
792
1.12
0.43
7.3
8.4
23.91
24.48
mmol/l
0.77
82
749
50
433
1.16
0.43
1.3
1.4
—
—
—
0
0
171
1591
1.08
0.43
1.5
1.4
—
—
—
0
0
14
104
1.35
0.43
1.1
1.1
—
—
—
0
0
11
78
1.41
0.43
1.8
1.4
—
—
—
0
0
5
31
1.61
0.43
2.2
1.4
—
—
—
0
0
8
56
1.43
0.42
1.6
1.1
—
—
—
0
0
332
3165
1.06
0.42
4.4
2.9
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
694
6750
1.04
0.40
3.6
3.5
1.72
1.79
ug/l
0.18
637
6247
33
279
1.19
0.39
1.2
1.2
—
—
—
0
0
28
233
1.20
0.38
1.6
1.3
—
—
—
0
0
47
410
1.15
0.38
1.1
1.1
1.97
2.40
u/ml
0.16
27
237
34
289
1.18
0.38
1.1
1.1
7.06
6.60
u/ml
0.04
15
131
15
116
1.30
0.37
1.1
1.1
0.17
6.44
u/ml
—
6
39
6
42
1.43
0.35
1.2
1.1
—
—
—
0
0
10
73
1.37
0.34
1.2
1.1
—
10.41
—
0
16
12
91
1.32
0.33
1.1
1.1
—
13.20
—
0
5
180
1906
0.94
0.33
1.7
1.4
—
—
—
0
0
11
83
1.33
0.32
1.0
1.1
102.38
213.75
iu/ml
2.00
11
83
14
110
1.27
0.31
1.2
1.2
1.03
1.06
ratio
—
7
39
27
230
1.18
0.31
4.4
4.2
991.51
240.72
u/ml
0.75
27
213
13
102
1.28
0.30
1.5
1.1
—
—
—
0
0
89
962
0.92
0.30
1.1
1.1
—
—
—
0
0
391
4034
0.96
0.28
2.5
2.4
0.66
0.67
ug/l
0.12
194
2185
34
300
1.14
0.26
2.3
2.0
—
—
—
0
0
38
338
1.13
0.26
1.3
1.2
—
—
—
0
0
9
74
1.22
0.25
1.3
1.2
—
—
—
0
0
14
114
1.23
0.25
2.3
2.2
648.00
622.96
ml
—
9
78
10
78
1.28
0.24
1.1
1.0
—
—
—
0
0
51
465
1.10
0.24
7.8
8.4
—
—
—
0
0
137
1442
0.95
0.23
1.5
1.4
—
—
—
0
0
32
286
1.12
0.21
1.1
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
4.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
35.17
—
0
6
111
1055
1.06
0.20
3.2
2.9
4.36
5.81
e9/l
1.20
87
926
31
344
0.90
0.19
2.8
2.2
149.63
152.10
ug/min
0.01
18
224
54
502
1.08
0.18
1.0
1.1
—
—
—
0
0
7
59
1.19
0.18
1.7
1.4
—
—
—
0
0
35
382
0.91
0.17
1.1
1.1
—
—
—
0
0
7
63
1.11
0.17
1.4
1.2
—
—
—
0
0
28
253
1.11
0.17
1.3
1.2
37.79
27.71
u/l
0.22
28
219
10
83
1.21
0.15
4.8
2.7
1921.90
2162.04
ml
—
10
78
1469
14768
0.98
0.15
21.6
14.2
334.80
334.97
g/l
0.30
1463
14672
21
188
1.12
0.14
1.1
1.1
—
—
—
0
0
23
208
1.11
0.14
1.2
1.4
70.39
137.93
pmol/l
0.59
23
201
35
324
1.08
0.14
1.1
1.1
12.31
3.87
u/ml
0.82
17
167
32
295
1.09
0.14
5.5
9.0
11.52
11.44
mmol/l
0.07
27
260
15
170
0.88
0.13
1.3
1.3
—
—
nmol/l
—
0
0
11
94
1.17
0.13
1.0
1.3
—
—
—
0
0
111
1071
1.04
0.12
2.4
2.2
12.73
9.97
ug/l
0.29
104
973
689
6819
1.02
0.12
2.9
2.5
—
—
—
0
0
69
660
1.05
0.11
1.1
1.1
—
—
—
0
0
36
384
0.94
0.11
1.1
1.1
—
—
—
0
0
14
125
1.12
0.10
1.1
1.1
4.96
6.50
iu/ml
—
5
30
5
45
1.11
0.09
1.0
1.1
—
—
—
0
0
43
412
1.04
0.07
2.4
2.4
27.09
43.59
u/ml
0.73
43
392
14
128
1.09
0.06
4.4
4.6
392.72
75.59
u/ml
—
6
40
17
183
0.93
0.06
1.2
1.4
—
0.28
nmol/l
—
0
15
10
93
1.08
0.02
1.6
1.5
—
—
—
0
0
12
113
1.06
0.01
1.1
1.2
—
—
—
0
0
38
388
0.98
0.01
2.2
2.6
—
—
—
0
0
11
116
0.95
0.00
1.7
1.6
7.58
6.70
mmol/l
—
6
78
27
276
0.98
0.00
1.1
1.1
0.24
0.40
u/ml
—
7
98
18
185
0.97
0.00
1.2
1.4
0.54
0.61
nmol/l
0.32
18
175
12
119
1.01
0.00
1.2
1.2
—
—
—
0
0
37
371
1.00
0.00
1.5
1.4
—
—
—
0
0
37
372
0.99
0.00
1.5
1.4
—
—
—
0
0
13
127
1.02
0.00
13.3
12.0
0.68
0.64
mmol/l
0.27
13
117
17
167
1.02
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
188.13
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
36.58
—
0
6
0
6
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1381.32
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
84
0.95
-0.00
1.1
1.0
—
—
—
0
0
5
53
0.94
-0.00
2.0
2.5
18.59
16.18
umol/l
—
5
53
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
67
0.90
-0.00
10.3
7.3
—
—
—
0
0
7
71
0.99
-0.00
1.7
1.2
168.29
202.59
mmol/24h
—
7
71
7
72
0.97
-0.00
1.4
1.1
—
—
—
0
0
8
83
0.96
-0.00
2.4
2.1
241.13
146.84
nmol/l
—
8
74
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
38
380
1.00
-0.00
1.6
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_VARICELLA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VARICELLA 2.371 [1.77, 3.17] < 0.001
Birth year 0.998 [0.99, 1.01] 0.578

During the follow-up period (1.1.1998 — 31.12.2019), 230 out of 5335 females with AB1_VARICELLA died.

Males

Parameter HR [95% CI] p-value
AB1_VARICELLA 2.514 [1.95, 3.24] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 291 out of 6337 males with AB1_VARICELLA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VARICELLA.

N-year risk Females Males
1 0.272% 0.409%
5 1.555% 2.968%
10 3.899% 7.396%
15 7.226% 14.074%
20 12.554% 22.812%

Relationships between endpoints

Index endpoint: AB1_VARICELLA – Varicella [chickenpox]

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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