Myelodysplastic syndrome, excluding all cancers (controls excluding all cancers)

C3_MYELODYSP_SYNDR_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D46
  • Cause of death: ICD-10 D46
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 9980|998[2-7]|9989
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

1018

4. Check minimum number of events

None

1018

5. Include endpoints

None

1018

6. Filter based on genotype QC (FinnGen only)

1018

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 1018 375 643
Unadjusted period prevalence (%) 0.23 0.13 0.28
Median age at first event (years) 73.63 71.28 75.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
274
Matched controls
2739
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
1131.2
198.7
171
*
9989/3-C42.1
ICD-O-3
Myelodysplastic syndrome, NOS, of bone marrow
+∞
193.4
162
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
181.7
149.1
146
17
XW000
NOMESCO Finland
Bone marrow biopsy
115.5
134.0
139
24
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
+∞
122.3
108
*
WW500
NOMESCO Finland
Blood transfusion
86.1
104.0
113
22
D64.9
ICD-10 Finland
Anaemia, unspecified
15.8
83.1
160
223
D46.2
ICD-10 Finland
Refractory anaemia with excess of blasts [RAEB]
860.8
70.3
66
*
A04AA01
ATC
ondansetron; systemic, rectal
46.6
48.7
59
16
B03XA02
ATC
darbepoetin alfa; parenteral
46.6
48.7
59
16
9983/3-C42.1
ICD-O-3
Myelodysplastic syndrome with excess blasts of bone marrow
+∞
45.1
42
*
D46.0
ICD-10 Finland
Refractory anaemia without ring sideroblasts, so stated
503.6
44.6
43
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
74.1
43.9
49
8
L03AA02
ATC
filgrastim; parenteral
169.2
42.1
43
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
41.7
39
*
D46.1
ICD-10 Finland
Refractory anaemia with ring sideroblasts
+∞
39.5
37
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
37.3
35
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
84.9
33.8
37
5
B03XA01
ATC
erythropoietin; parenteral
42.5
30.2
37
10
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
298.8
27.2
27
*
Z51.5
ICD-10 Finland
Palliative care
14.7
26.5
45
36
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
25.4
24
*
127
Kela drug reimbursment
Transplant complication
77.5
25.3
28
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
62.0
24.5
28
5
ZX112
NOMESCO Finland
Subcutaneous
62.0
24.5
28
5
306
Kela drug reimbursment
Erythropoietin and darbepoetin
91.4
23.1
25
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.3
22.8
78
191
L04AD01
ATC
ciclosporin; systemic
47.7
21.8
26
6
C61
ICD-10 Finland
Malignant neoplasm of prostate
83.5
21.0
23
*
ZX120
NOMESCO Finland
Intravenous
7.3
20.7
52
85
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
+∞
19.0
18
*
JN4BD
NOMESCO Finland
Extensive body CT
8.7
18.7
41
54
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.8
18.7
32
26
A05AA02
ATC
ursodeoxycholic acid; oral
29.0
18.1
24
9
R50.9
ICD-10 Finland
Fever, unspecified
4.7
18.1
68
181
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
+∞
17.9
17
*
116
Kela drug reimbursment
Prostate cancer
+∞
17.9
17
*
9982/3-C42.1
ICD-O-3
Myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia of bone marrow
+∞
16.8
16
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
15.8
15
*
Y84.8
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
84.8
14.7
16
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
14.7
14
*
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
14.7
14
*
B82
ICPC
Anaemia other/unspecified
11.0
14.3
27
27
H02AB06
ATC
prednisolone; systemic
2.7
13.7
147
826
1BC07
NOMESCO Finland
NA
+∞
13.7
13
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
147.0
13.6
14
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.5
13.3
27
31
N02AA05
ATC
oxycodone; systemic
3.7
13.2
64
211
SPAT1088
SPAT
Blood transfusion
52.6
13.0
15
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
73.4
12.7
14
*
WW200
NOMESCO Finland
Immunization
14.1
12.7
21
16
9985/3-C42.1
ICD-O-3
Myelodysplastic syndrome with multilineage dysplasia of bone marrow
+∞
12.6
12
*
9980/3-C42.1
ICD-O-3
Myelodysplastic syndrome with single lineage dysplasia of bone marrow
+∞
12.6
12
*
M04AA01
ATC
allopurinol; systemic
3.1
11.8
75
300
J02AC03
ATC
voriconazole; systemic
67.9
11.7
13
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.2
11.6
31
55
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
11.5
11
*
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
+∞
11.5
11
*
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
11.5
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
11.4
53
168
L04AA06
ATC
mycophenolic acid; systemic
21.1
11.3
16
8
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.7
11.2
32
62
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.5
11.0
22
25
J01MA12
ATC
levofloxacin; systemic
2.9
10.9
76
319
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
10.9
120
659
A03FA01
ATC
metoclopramide; systemic, rectal
3.7
10.7
48
147
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.0
10.7
67
264
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.0
10.6
29
53
D46.4
ICD-10 Finland
Refractory anaemia, unspecified
114.2
10.5
11
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
10.5
10
*
J05AB11
ATC
valaciclovir; oral
3.8
10.5
45
133
A41.9
ICD-10 Finland
Sepsis, unspecified
6.1
10.4
28
50
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
10.1
106
563
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
10.1
132
782
JN4AD
NOMESCO Finland
Body CT examination
7.6
9.7
22
31
B73
ICPC
Leukaemia
+∞
9.4
9
*
D46.3
ICD-10 Finland
Refractory anemia with excess of blasts with transformation
+∞
9.4
9
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
9.4
9
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
9.4
9
*
V03AC03
ATC
deferasirox; oral
+∞
9.4
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
9.0
98
524
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
8.9
118
693
L02BB03
ATC
bicalutamide; oral
+∞
8.4
8
*
D46
ICD-10 Finland
Myelodysplastic syndromes
+∞
8.4
8
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
+∞
8.4
8
*
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
34.5
8.1
10
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
22.8
8.1
11
5
A02BC02
ATC
pantoprazole; systemic
2.1
8.0
167
1172
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
7.8
65
298
UJF30
NOMESCO Finland
Ileoscopy through colon
4.0
7.8
30
81
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
82.2
7.5
8
*
J01MA02
ATC
ciprofloxacin; systemic
2.1
7.4
121
759
130
Kela drug reimbursment
Malignant tumour
+∞
7.3
7
*
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
+∞
7.3
7
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
7.3
7
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
7.3
7
*
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
7.3
7
*
TNE20
NOMESCO Finland
Bone marrow aspiration, pelvis
+∞
7.3
7
*
J01MA14
ATC
moxifloxacin; systemic
3.5
7.2
33
103
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
7.2
29
82
TGC00
NOMESCO Finland
Bronchial lavation
7.3
7.1
16
23
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.4
6.7
23
56
H02AB04
ATC
methylprednisolone; systemic
2.6
6.5
48
206
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.3
6.5
32
106
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.5
6.4
13
16
H02AB02
ATC
dexamethasone; systemic
11.4
6.4
11
10
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.3
6.3
18
36
B74
ICPC
Malignant neoplasm blood other
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
115
Kela drug reimbursment
Breast cancer
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
9945/3-C42.1
ICD-O-3
Chronic myelomonocytic leukemia, NOS, of bone marrow
+∞
6.3
6
*
WW409
NOMESCO Finland
Other aferesis
+∞
6.3
6
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
6.3
6
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
6.3
6
*
H02AB07
ATC
prednisone; oral
2.5
6.1
48
214

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
359
55
100.29
307.65
1.5
1.1
—
—
—
0
0
358
101
54.13
307.65
3.0
1.2
—
—
—
0
0
581
1054
11.51
307.65
7.4
1.9
2.0
1.8
%
2.94
537
916
316
131
34.53
307.65
1.4
1.1
136.9
20.7
u/l
12.83
281
117
512
774
12.30
307.65
7.1
2.1
70.1
67.5
e9/l
0.30
426
614
231
49
60.69
307.65
1.8
1.1
—
—
—
0
0
262
190
18.22
295.94
2.7
1.5
—
—
—
0
0
344
404
12.35
287.35
2.4
1.6
1.1
1.5
g/l
8.28
292
341
350
527
9.60
238.18
13.9
3.5
1.5
0.8
%
3.38
252
122
176
87
24.25
236.72
10.3
3.2
1.3
1.5
%
0.10
139
59
104
17
68.02
189.39
3.1
1.2
—
—
—
0
0
187
176
12.79
177.82
1.7
1.3
—
—
—
0
0
284
476
7.89
172.05
14.1
3.5
0.8
0.5
%
0.91
169
89
289
502
7.64
169.21
14.3
3.6
0.2
0.0
%
1.89
225
113
332
693
6.63
161.79
2.8
1.6
66.7
66.5
g/l
0.12
311
606
124
67
20.94
159.18
9.8
3.0
49.3
55.8
%
0.98
82
41
119
68
19.68
148.73
12.2
3.3
—
—
—
0
0
261
476
7.03
144.40
14.5
3.6
0.8
0.9
%
0.05
182
95
241
423
7.15
137.99
3.3
2.1
11.1
11.0
g/l
0.11
219
384
427
1262
5.11
137.99
3.1
2.4
17.3
12.4
umol/l
16.92
409
1139
389
1072
5.25
136.70
3.2
2.5
36.5
22.4
%
21.51
335
895
399
1142
5.10
133.51
3.1
2.4
2.0
2.2
g/l
12.82
386
1046
282
605
6.06
131.28
2.7
1.5
—
—
—
0
0
108
72
16.66
124.70
1.1
1.2
—
—
—
0
0
568
2289
4.35
118.42
23.1
4.8
—
—
—
0
0
171
261
7.67
110.39
2.5
1.4
5.1
1.3
ratio
1.03
13
22
172
268
7.52
108.93
2.5
1.4
48.9
50.8
mg/l
0.11
150
212
194
345
6.71
108.38
2.1
1.3
1.5
1.1
g/l
0.75
175
313
99
73
14.91
107.97
1.5
1.3
110.4
112.7
u/ml
—
29
6
171
268
7.47
107.68
2.5
1.4
50.8
37.2
mg/l
0.38
147
214
653
3095
4.10
103.86
21.9
5.0
0.8
0.6
%
3.27
629
2831
665
3208
4.09
102.65
25.0
5.3
11.9
8.9
%
17.61
639
2937
169
276
7.14
102.25
1.4
1.3
—
—
—
0
0
661
3192
4.05
101.49
22.9
5.0
2.3
3.0
%
8.16
635
2909
76
37
22.12
101.37
1.4
1.2
—
—
—
0
0
666
3261
4.01
99.50
24.0
5.1
30.5
25.7
%
13.96
641
2969
76
39
20.98
99.10
2.8
2.4
—
—
—
0
0
138
194
8.07
95.35
2.7
1.4
—
—
—
0
0
511
2146
3.77
95.20
3.2
2.2
3.2
3.0
mg/l
0.78
451
1797
95
86
12.08
91.28
1.4
1.3
—
—
—
0
0
609
2940
3.67
89.97
5.5
2.8
464.5
138.9
ug/l
28.99
577
2657
91
80
12.39
89.07
1.3
1.1
310.5
278.1
u/ml
0.28
57
40
494
2101
3.63
88.85
15.9
2.2
—
—
—
0
0
644
3239
3.69
88.82
21.0
5.0
50.1
58.9
%
35.97
615
2972
210
483
5.22
88.14
1.5
1.5
—
—
—
0
0
103
114
9.94
85.99
1.3
1.2
—
—
—
0
0
674
3544
3.67
85.46
20.9
4.8
0.1
0.2
e9/l
20.18
614
3049
471
1991
3.54
84.64
5.9
2.5
1346.4
8695.2
umol/l
4.81
437
1667
62
30
21.94
82.69
6.0
1.9
0.8
1.0
e9/l
0.30
33
17
653
3415
3.54
82.45
18.3
4.7
0.7
0.6
e9/l
0.74
598
2892
312
1027
3.94
81.65
7.5
4.6
1.1
1.0
mmol/l
3.79
293
928
654
3437
3.52
81.63
18.4
4.8
0.0
0.0
e9/l
1.29
599
2917
671
3583
3.56
81.59
16.7
3.6
13.9
12.6
umol/l
1.80
649
3326
694
3801
3.59
80.62
33.3
5.5
3.5
4.5
e9/l
3.82
642
3262
656
3493
3.47
79.30
19.5
4.9
1.5
1.8
e9/l
12.87
611
3006
216
561
4.62
77.63
1.5
1.5
—
—
—
0
0
53
20
27.90
77.58
6.7
1.8
440.8
919.7
e6/l
—
27
10
237
672
4.29
75.84
1.5
1.6
—
—
—
0
0
47
13
37.86
75.54
1.1
1.0
—
—
—
0
0
500
2331
3.25
74.19
8.9
4.0
—
—
—
0
0
44
10
45.94
74.18
1.0
1.0
—
—
—
0
0
44
10
45.94
74.18
1.7
1.1
—
—
—
0
0
598
3147
3.18
71.00
24.0
3.7
—
—
—
0
0
303
1072
3.60
69.98
5.9
2.3
0.8
0.8
mmol/l
2.79
283
977
343
1319
3.41
69.36
18.1
3.8
—
—
—
0
0
438
1965
3.16
68.14
2.2
1.8
1322.9
1169.7
nmol/l
2.25
351
1472
385
1610
3.24
67.47
14.6
2.1
—
—
—
0
0
149
329
5.13
64.69
2.1
1.4
12.0
10.7
g/l
1.51
127
273
100
164
6.65
59.42
1.5
1.2
—
—
—
0
0
314
1258
3.16
57.89
3.2
1.8
30.1
30.1
s
0.06
303
1215
649
3849
2.89
57.35
12.8
5.4
1.2
1.2
mmol/l
5.86
559
3231
45
24
19.57
57.30
2.8
2.0
13.0
15.9
%
0.34
19
11
217
706
3.64
55.84
8.9
2.5
8.2
9.4
umol/l
0.50
206
600
426
2131
2.72
50.90
2.2
1.6
20.5
20.0
nmol/l
0.22
394
1791
64
75
9.04
50.80
1.2
1.0
—
—
—
0
0
69
89
8.24
50.71
7.8
6.5
12.1
12.4
mg/l
0.21
62
82
137
346
4.42
50.01
2.4
1.6
7.0
2.1
ug/l
0.65
115
298
590
3490
2.64
49.68
10.7
5.1
1.2
1.2
mmol/l
4.68
553
3072
554
3240
2.56
46.83
9.8
3.7
33.6
34.7
g/l
3.49
521
2955
201
692
3.37
46.78
8.5
5.4
11.1
11.7
mmol/l
0.41
191
641
268
1106
2.93
45.57
1.7
1.3
2.8
2.8
g/l
0.03
200
617
115
277
4.55
44.45
2.1
1.4
37.3
36.7
g/l
0.36
100
227
37
26
14.73
40.95
2.9
1.9
41.9
45.9
%
0.21
12
14
48
9
55.86
40.83
4.9
1.0
—
—
—
0
0
576
3577
2.41
40.64
3.0
2.1
90.4
91.8
pmol/l
0.29
399
1859
414
2225
2.45
40.48
8.3
3.1
7.4
7.4
ph
0.63
82
381
56
76
7.74
39.34
2.0
1.3
—
—
—
0
0
56
76
7.74
39.34
2.0
1.3
—
—
—
0
0
56
76
7.74
39.34
2.0
1.3
—
—
—
0
0
56
76
7.74
39.34
2.0
1.3
—
—
—
0
0
75
148
5.39
36.56
1.4
2.1
15.3
12.3
mg/l
0.74
62
135
26
11
24.23
36.12
2.9
1.8
—
—
—
0
0
55
81
7.12
35.93
1.3
1.0
—
—
—
0
0
244
1074
2.67
35.77
2.3
2.0
—
—
—
0
0
42
47
9.28
34.41
2.5
1.6
—
—
—
0
0
191
771
2.82
32.91
1.5
1.3
584.1
581.0
titre
0.01
58
181
23
10
23.51
31.54
1.2
1.0
—
—
—
0
0
309
1599
2.34
31.45
24.5
4.4
—
—
—
0
0
25
15
17.06
29.86
1.1
1.0
—
—
—
0
0
124
416
3.26
29.46
2.6
1.4
13.7
3.8
ug/l
0.49
95
309
36
41
9.07
29.06
1.1
1.0
—
—
—
0
0
280
1447
2.29
28.14
2.3
1.6
1.8
1.3
mg/l
1.84
242
1124
24
16
15.34
27.15
1.2
1.1
—
—
—
0
0
723
5494
2.09
24.63
21.7
5.1
81.6
78.0
u/l
0.92
698
5005
121
444
2.96
24.53
4.9
3.0
3.5
4.2
e9/l
0.83
81
307
299
1667
2.12
24.37
8.3
3.6
76.3
81.0
%
2.69
292
1617
26
24
11.09
24.29
1.2
1.2
—
—
—
0
0
21
14
15.29
23.70
1.2
1.1
—
—
—
0
0
292
1641
2.09
23.13
2.0
1.3
—
—
—
0
0
187
881
2.38
22.84
1.9
1.7
—
—
—
0
0
371
2293
1.97
22.41
2.9
2.2
53.3
56.9
u/l
1.27
344
2093
622
4565
1.93
22.32
8.5
4.3
7.0
7.0
mmol/l
0.20
602
4266
331
1999
1.97
21.14
2.5
1.7
—
—
—
0
0
136
573
2.59
21.05
2.2
2.0
0.2
0.2
g/l
1.02
115
505
42
87
4.99
19.33
1.1
1.1
—
—
—
0
0
38
72
5.44
19.31
1.9
1.3
—
—
—
0
0
45
101
4.62
18.84
9.0
2.8
54.4
60.2
%
1.32
45
101
164
799
2.25
18.27
8.3
3.7
—
—
—
0
0
161
780
2.26
18.18
2.8
1.4
—
—
—
0
0
479
3380
1.79
17.99
9.6
12.3
1.3
1.4
inr
2.58
129
932
441
3039
1.80
17.93
33.6
8.5
0.1
0.0
e9/l
0.65
387
2451
23
29
8.09
17.07
1.2
1.0
57.5
64.4
mg/l
0.20
17
18
328
2110
1.82
16.47
4.4
3.1
0.7
0.5
e6/l
0.50
262
1624
416
2881
1.75
16.16
3.6
3.2
2185.0
1888.7
ng/l
0.69
380
2502
352
2335
1.78
15.81
4.5
3.1
174.6
95.3
e6/l
0.38
287
1823
20
6
33.95
15.77
1.2
1.0
—
—
—
0
0
174
921
2.07
15.56
1.4
1.2
—
—
—
0
0
14
10
14.18
15.06
1.4
1.1
—
—
—
0
0
19
22
8.78
15.05
1.3
1.1
—
—
—
0
0
306
1983
1.78
14.69
1.8
1.8
50612749.0
12825696.6
pmol/l
0.34
245
1614
38
92
4.25
14.49
1.5
1.5
238811.2
95475.5
e6/l
0.33
25
56
40
101
4.08
14.44
1.5
1.5
1039.2
1742.1
e6/l
0.99
33
71
52
158
3.41
14.39
3.6
3.5
1.5
1.7
mg/l
0.83
46
135
385
2677
1.70
14.30
5.2
3.6
58.6
116.2
e6/l
1.98
302
1949
139
700
2.14
14.10
5.9
5.5
1.6
1.5
mmol/l
0.16
133
665
116
543
2.28
14.09
6.3
3.7
7.4
7.4
ph
1.78
14
63
309
2029
1.75
14.07
4.4
3.0
—
—
—
0
0
83
335
2.61
13.92
7.3
4.1
24.8
24.7
mmol/l
0.06
76
301
162
870
2.03
13.84
6.3
6.0
94.6
94.8
%
0.16
156
832
117
555
2.25
13.76
6.3
3.6
5.1
5.2
kpa
0.17
105
504
60
205
3.05
13.72
1.4
1.2
3.0
0.3
u/ml
—
9
19
630
5014
1.67
13.71
6.6
4.7
13.0
3160.2
e6/l
—
8
96
36
88
4.20
13.56
1.5
1.5
—
—
—
0
0
204
1197
1.88
13.41
3.9
3.0
1.6
2.2
e6/l
0.87
114
670
21
32
6.68
13.23
1.4
1.1
—
—
—
0
0
214
1282
1.85
13.16
3.7
2.7
2.1
1.3
e6/l
0.77
127
751
663
5377
1.67
13.13
6.8
4.1
24.2
13.8
mm/h
22.72
619
4877
137
707
2.08
13.01
4.6
3.2
—
—
—
0
0
146
775
2.03
12.84
6.6
6.4
103.6
121.1
g/l
15.64
141
750
354
2472
1.66
12.57
3.6
2.1
2.3
2.3
mmol/l
4.01
302
2007
16
19
8.54
12.39
8.5
1.5
—
—
—
0
0
170
972
1.90
12.01
6.2
5.9
4.9
5.1
kpa
0.75
164
920
170
972
1.90
12.01
6.2
5.8
11.4
11.2
kpa
0.15
164
917
119
600
2.11
11.98
2.0
1.7
341.7
363.3
nmol/l
0.58
114
535
46
151
3.14
11.28
2.9
2.4
33.8
35.2
umol/l
0.12
32
131
31
78
4.07
11.27
1.6
1.5
—
—
—
0
0
21
38
5.62
11.20
1.5
1.3
—
—
—
0
0
355
2539
1.61
11.17
4.3
3.3
—
—
—
0
0
70
290
2.52
11.14
1.2
1.4
—
—
—
0
0
167
974
1.85
11.04
6.3
5.8
1.2
1.3
mmol/l
0.12
129
737
97
467
2.19
10.97
1.6
1.1
—
—
—
0
0
14
17
8.34
10.63
1.7
1.0
—
—
—
0
0
249
1646
1.68
10.63
3.4
2.4
5.6
5.2
e6/l
0.20
225
1436
149
850
1.88
10.54
4.6
3.2
1.6
2.0
mmol/l
0.61
119
664
86
401
2.25
10.52
6.7
3.9
—
—
—
0
0
31
83
3.82
10.37
1.5
1.7
1.0
1.0
g/l
0.02
23
64
24
53
4.61
10.28
1.3
1.3
—
—
—
0
0
33
95
3.56
9.96
2.6
2.8
—
—
—
0
0
92
451
2.14
9.95
3.1
2.4
—
—
—
0
0
150
881
1.82
9.64
4.6
3.3
—
7.4
—
0
6
24
56
4.37
9.62
1.2
1.2
—
—
—
0
0
23
53
4.42
9.36
1.2
1.2
—
—
—
0
0
621
5170
1.52
9.21
6.4
4.3
—
—
—
0
0
233
1565
1.63
9.20
3.7
2.6
525.5
550.8
mosm/kgh2o
1.24
208
1310
105
561
1.97
9.00
2.4
2.1
48.0
30.7
u/l
0.58
89
446
29
82
3.61
9.00
1.6
1.6
—
—
—
0
0
13
18
7.30
8.86
1.2
1.2
1.6
1.3
ug/l
—
7
9
84
417
2.11
8.80
7.7
8.3
—
—
—
0
0
109
609
1.88
8.18
4.1
2.8
1.2
1.2
mmol/l
3.34
104
508
71
341
2.16
8.10
1.3
1.3
—
—
—
0
0
22
55
4.07
8.10
1.2
1.2
—
—
—
0
0
43
166
2.66
7.94
1.4
1.2
1.7
3.3
u/ml
—
7
16
22
56
3.99
7.91
1.2
1.2
3.3
2.6
g/l
0.72
15
42
22
56
3.99
7.91
1.2
1.2
7.1
7.7
g/l
0.29
15
42
22
56
3.99
7.91
1.2
1.2
0.6
0.4
g/l
1.00
15
42
427
3363
1.46
7.90
5.5
4.3
77.3
77.5
ng/l
0.00
351
2591
242
1697
1.56
7.84
4.6
4.2
244.2
449.5
ng/l
1.20
208
1480
104
583
1.87
7.73
5.9
6.2
24.4
24.4
mmol/l
0.00
97
545
115
666
1.82
7.70
7.9
6.6
—
—
—
0
0
23
63
3.71
7.49
1.1
1.2
3.5
7.1
u/ml
0.55
13
31
452
3630
1.44
7.40
4.9
3.8
0.0
0.0
estimate
0.00
87
633
110
638
1.81
7.33
3.5
3.7
82.9
94.5
ng/l
0.83
93
548
104
598
1.82
7.13
4.2
4.2
—
—
—
0
0
451
3670
1.41
6.63
5.0
3.8
0.0
0.0
estimate
0.00
82
619
49
222
2.27
6.48
4.4
3.5
—
—
—
0
0
6
0
+∞
6.25
1.3
0.0
7.0
—
%
—
6
0
6
0
+∞
6.25
1.5
0.0
—
—
—
0
0
6
0
+∞
6.25
1.0
0.0
—
—
—
0
0
17
43
4.00
6.18
1.2
1.7
12.2
15.2
umol/l
0.87
17
36
442
3618
1.39
6.13
6.6
5.1
0.0
0.0
estimate
0.00
86
619
69
367
1.94
6.03
5.7
4.0
0.9
0.9
%
0.40
64
350
73
400
1.89
5.85
4.0
3.7
24.2
24.2
mmol/l
0.01
63
349
38
163
2.38
5.71
1.2
1.1
101.7
75.5
titre
—
6
11
8
5
16.12
5.41
1.4
1.0
—
—
—
0
0
357
2869
1.38
5.35
4.6
3.6
—
—
—
0
0
37
162
2.33
5.33
4.1
3.3
—
—
—
0
0
68
376
1.87
5.31
5.8
3.9
1.8
1.7
%
0.22
63
359
325
2580
1.38
5.23
2.5
2.2
357.0
273.6
u/l
0.14
304
2408
5
0
+∞
5.21
2.2
0.0
—
—
—
0
0
19
59
3.26
5.19
1.3
1.0
—
—
—
0
0
186
1349
1.46
4.95
22.3
31.3
1.4
1.5
inr
0.54
27
185
147
1021
1.51
4.84
1.3
1.3
32.3
38.6
iu/ml
0.22
43
319
28
114
2.50
4.74
2.2
2.6
—
—
—
0
0
38
178
2.18
4.71
6.2
4.2
2.3
2.8
mmol/l
0.39
26
121
60
333
1.85
4.66
2.2
2.1
747.4
542.0
ug/l
0.25
53
308
131
1857
0.66
4.64
1.9
1.6
1.4
1.3
mmol/l
0.59
115
1530
10
21
4.80
4.54
1.1
1.0
1501.8
1760.3
miu/ml
—
10
21
233
1791
1.39
4.47
5.1
3.7
—
—
—
0
0
12
30
4.04
4.44
1.6
1.1
—
—
—
0
0
43
217
2.02
4.42
6.0
4.0
7.4
7.4
ph
0.46
36
174
141
991
1.49
4.38
1.3
1.2
20.9
15.1
u/ml
0.26
50
349
11
26
4.27
4.36
1.9
1.3
64.0
61.8
%
0.07
11
21
37
178
2.12
4.31
1.2
1.2
—
602.0
—
0
5
39
192
2.07
4.29
6.1
5.5
10.9
11.2
mmol/l
0.20
34
176
39
192
2.07
4.29
6.1
5.6
104.7
105.5
mmol/l
0.40
34
176
51
277
1.89
4.26
5.6
5.2
1.3
1.3
mmol/l
0.20
46
247
40
200
2.04
4.22
3.9
3.3
7.5
7.8
kpa
0.45
35
184
13
36
3.64
4.21
4.9
2.9
—
—
—
0
0
28
122
2.33
4.13
1.5
1.4
—
—
—
0
0
25
104
2.44
4.08
2.3
1.6
87.9
89.7
%
0.93
25
104
40
203
2.01
4.07
1.7
1.6
22094.3
15580.8
e6/l
0.48
32
144
15
47
3.22
4.06
2.2
2.1
—
—
—
0
0
49
267
1.88
4.06
3.7
2.7
0.2
0.3
g/l
0.33
28
84
13
37
3.55
4.06
1.3
1.1
—
—
—
0
0
96
632
1.57
4.03
1.4
1.3
—
—
—
0
0
131
926
1.48
3.96
3.4
3.2
294.1
277.4
ng/l
0.17
115
863
26
115
2.29
3.73
1.5
1.1
—
—
—
0
0
127
903
1.46
3.73
3.0
2.6
5.1
6.6
ug/l
0.92
100
773
34
170
2.03
3.62
3.4
2.2
12.9
15.9
%
3.78
18
84
69
431
1.64
3.61
3.0
2.6
0.4
0.3
e6/l
0.18
69
421
172
1301
1.39
3.59
1.3
1.2
3.0
1.5
u/ml
0.54
43
335
32
157
2.07
3.59
1.4
1.5
—
—
—
0
0
252
2023
1.33
3.58
5.4
4.1
0.0
0.0
estimate
0.00
80
593
7
9
7.82
3.56
1.1
1.0
—
—
—
0
0
14
46
3.07
3.54
1.3
1.5
14.3
15.8
ug/l
0.27
14
46
9
17
5.33
3.51
1.8
2.1
—
—
—
0
0
6
6
10.05
3.50
1.0
1.0
—
—
—
0
0
767
7121
1.31
3.43
48.6
15.1
29.0
26.5
mg/l
1.11
723
5695
18
70
2.60
3.39
1.2
1.2
—
—
—
0
0
9
18
5.03
3.37
3.2
2.3
—
—
—
0
0
8
14
5.75
3.34
1.4
1.1
—
—
—
0
0
99
687
1.49
3.30
2.0
1.9
206.4
169.7
ug/g
0.26
80
518
6
7
8.61
3.26
1.0
1.0
—
—
—
0
0
6
7
8.61
3.26
1.0
1.0
—
—
—
0
0
58
357
1.66
3.24
5.5
4.6
—
—
—
0
0
8
15
5.37
3.19
1.1
1.7
—
—
—
0
0
15
55
2.75
3.16
3.8
2.9
—
—
—
0
0
8
229
0.34
3.08
1.6
1.4
—
—
—
0
0
22
99
2.25
3.07
1.5
1.4
54.7
67.4
%
0.61
15
65
6
8
7.54
3.06
1.2
1.3
—
—
—
0
0
150
1939
0.73
3.05
3.0
3.4
—
—
—
0
0
8
16
5.03
3.05
4.0
1.7
—
—
—
0
0
8
16
5.03
3.05
1.3
1.6
—
—
—
0
0
7
12
5.86
3.02
3.0
2.0
—
—
—
0
0
5
5
10.04
2.98
1.0
1.0
—
—
—
0
0
31
162
1.94
2.97
3.1
2.7
—
—
—
0
0
34
185
1.87
2.90
1.3
1.4
234.9
299.4
ug/g
0.94
18
109
665
7151
0.80
2.90
4.8
5.4
2.1
2.5
mmol/l
22.02
591
6437
286
2417
1.25
2.65
5.6
4.4
—
—
—
0
0
15
61
2.48
2.62
1.5
1.4
143.8
69.9
pmol/l
0.82
15
61
42
253
1.69
2.59
2.5
3.4
0.8
0.8
nmol/l
0.11
23
200
17
74
2.32
2.59
1.5
1.3
26278.3
345215.5
e6/l
1.25
12
48
19
87
2.21
2.58
1.6
1.3
—
—
—
0
0
151
1888
0.76
2.41
3.3
2.8
0.7
0.8
ug/l
0.41
95
1347
635
6811
0.82
2.41
6.5
6.7
39.8
41.3
mmol/mol
3.18
576
6208
36
213
1.72
2.38
1.2
1.1
—
—
—
0
0
47
299
1.60
2.37
2.4
2.0
—
—
—
0
0
16
71
2.27
2.35
4.5
3.1
—
—
—
0
0
25
134
1.89
2.28
1.4
1.4
—
—
—
0
0
32
189
1.72
2.15
2.7
2.0
102.3
130.5
g/l
6.49
23
139
9
30
3.02
2.15
1.1
1.0
—
—
—
0
0
42
268
1.59
2.12
2.4
1.8
—
—
—
0
0
8
25
3.22
2.09
1.1
1.1
99.5
135.2
iu/ml
—
8
25
8
191
0.41
2.06
1.3
1.5
—
—
—
0
0
27
154
1.77
2.05
1.3
1.4
56.8
63.0
mmol/l
0.28
20
123
576
5317
1.19
2.05
3.9
3.6
15.0
15.1
pmol/l
0.36
516
4706
32
192
1.69
2.05
1.6
1.2
—
—
—
0
0
6
15
4.02
2.04
1.5
1.3
—
—
—
0
0
40
255
1.59
2.03
1.6
1.2
—
—
—
0
0
6
160
0.37
2.03
1.2
1.1
—
—
—
0
0
8
26
3.09
2.01
1.1
1.6
—
—
—
0
0
67
479
1.43
2.00
1.1
1.2
—
—
—
0
0
645
6860
0.84
1.99
4.4
4.7
1.3
1.4
mmol/l
10.96
569
6158
5
11
4.56
1.94
1.4
4.3
2.0
1.3
umol/l
—
5
11
654
6940
0.84
1.93
4.4
4.8
3.8
4.4
mmol/l
29.95
584
6278
9
33
2.74
1.93
1.1
1.1
—
—
—
0
0
77
574
1.37
1.82
5.0
3.8
—
—
—
0
0
12
56
2.16
1.61
2.2
1.7
—
—
—
0
0
8
32
2.51
1.60
1.3
2.6
—
—
—
0
0
5
15
3.34
1.52
1.4
1.1
—
—
—
0
0
11
51
2.17
1.51
1.1
1.4
—
—
—
0
0
205
1770
1.20
1.50
5.4
4.2
1.0
1.0
kg/l
0.10
36
296
16
87
1.85
1.46
1.5
1.5
—
—
—
0
0
12
59
2.05
1.44
1.0
1.2
—
—
—
0
0
9
39
2.32
1.43
1.3
1.5
—
1956.8
—
0
14
21
126
1.68
1.41
2.8
2.2
105.8
105.1
mmol/l
0.32
21
126
21
126
1.68
1.41
2.8
2.2
4.1
4.1
mmol/l
0.29
21
126
643
6088
1.15
1.40
49.9
16.6
32.0
38.5
%
33.83
361
3630
58
434
1.36
1.39
1.2
1.3
—
—
—
0
0
629
6615
0.87
1.34
4.6
4.2
1.2
1.3
mmol/l
1.17
560
5875
13
68
1.92
1.33
2.0
2.7
7.3
7.2
mmol/l
—
8
43
20
122
1.65
1.28
2.9
2.2
—
—
—
0
0
10
48
2.09
1.28
1.1
1.1
—
—
—
0
0
55
416
1.34
1.25
2.4
2.5
—
16.4
—
0
7
213
1876
1.17
1.25
4.5
3.5
—
—
—
0
0
10
49
2.05
1.22
2.5
2.4
—
—
—
0
0
30
207
1.46
1.16
6.4
2.8
7.9
7.8
mmol/l
0.03
30
202
52
672
0.76
1.12
1.6
1.6
—
—
—
0
0
27
184
1.48
1.11
2.9
2.3
—
—
—
0
0
7
137
0.51
1.10
1.0
1.7
—
—
—
0
0
60
470
1.29
1.10
4.5
3.7
—
—
—
0
0
173
1515
1.17
1.10
3.2
2.3
2.4
2.4
mmol/l
2.00
159
1284
10
53
1.90
1.01
1.3
1.7
—
—
—
0
0
35
258
1.37
0.98
4.8
4.4
—
—
—
0
0
9
50
1.81
0.96
1.7
1.1
—
—
—
0
0
13
77
1.70
0.95
1.3
1.3
—
—
—
0
0
9
51
1.77
0.94
1.7
1.1
—
—
—
0
0
684
7082
0.90
0.90
5.7
5.0
6.1
6.1
mmol/l
0.55
601
6296
6
29
2.08
0.89
2.3
1.2
—
—
—
0
0
10
56
1.79
0.88
1.0
1.1
—
—
—
0
0
588
5625
1.11
0.87
64.2
17.8
16.8
13.8
%
72.44
583
5447
40
311
1.30
0.82
1.1
1.2
41.7
114.6
iu/ml
1.86
14
121
32
241
1.34
0.81
1.2
1.1
—
120.2
—
0
6
8
47
1.71
0.80
1.6
1.1
—
—
—
0
0
12
74
1.63
0.78
5.0
3.5
19.1
40.3
mg/l
—
7
64
5
24
2.09
0.74
3.2
2.4
—
—
—
0
0
7
38
1.85
0.73
1.3
1.7
—
—
—
0
0
5
25
2.00
0.72
1.4
1.3
—
—
—
0
0
10
60
1.67
0.72
1.7
1.5
—
—
—
0
0
9
57
1.58
0.71
1.4
1.6
—
—
—
0
0
7
41
1.71
0.70
2.0
1.4
—
—
—
0
0
5
27
1.86
0.68
1.8
1.6
—
—
—
0
0
66
559
1.19
0.67
3.0
3.1
—
—
—
0
0
12
174
0.69
0.59
1.0
1.1
—
—
—
0
0
18
139
1.30
0.44
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.8
1.3
—
—
—
0
0
32
268
1.20
0.41
1.3
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
8.1
—
—
—
0
0
8
59
1.36
0.41
1.3
1.3
—
—
—
0
0
26
214
1.22
0.39
1.7
1.6
—
—
—
0
0
671
6577
1.06
0.37
4.9
4.5
2.2
2.2
mu/l
0.00
611
5847
506
5195
0.95
0.36
5.4
4.3
—
—
—
0
0
770
7585
1.06
0.34
45.9
18.6
138.9
139.7
mmol/l
13.35
751
7333
564
5765
0.95
0.33
67.3
20.1
327.7
331.8
g/l
15.39
557
5694
31
269
1.16
0.29
24.2
12.1
—
—
—
0
0
17
139
1.23
0.29
1.1
1.1
—
—
—
0
0
770
7600
1.05
0.29
48.2
18.8
4.0
4.0
mmol/l
1.92
753
7339
12
151
0.79
0.28
2.8
1.3
0.8
0.8
nmol/l
—
7
126
56
510
1.10
0.26
1.6
1.5
—
—
—
0
0
5
38
1.32
0.23
1.2
1.3
—
—
—
0
0
5
38
1.32
0.23
1.2
1.3
—
—
—
0
0
11
88
1.25
0.22
1.4
1.2
0.7
0.7
nmol/l
0.12
11
83
5
40
1.25
0.22
1.2
1.5
—
—
—
0
0
14
116
1.21
0.22
1.3
1.2
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
5.2
—
0
8
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
206.4
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
354
3457
1.04
0.20
4.9
4.1
2.1
2.2
ug/l
0.33
301
3057
14
117
1.20
0.20
2.6
2.9
—
—
—
0
0
10
80
1.25
0.20
2.3
2.3
898.0
633.6
ml
—
5
54
16
136
1.18
0.20
2.2
2.3
60.4
60.8
%
0.02
16
136
10
82
1.22
0.17
1.0
1.3
114.1
59.0
mu/l
—
10
72
7
63
1.11
0.17
1.7
2.1
9.3
10.3
%
—
7
63
7
63
1.11
0.17
1.0
1.1
—
—
—
0
0
735
7285
1.03
0.16
40.8
15.0
—
—
—
0
0
50
533
0.93
0.15
1.3
1.4
—
—
—
0
0
9
81
1.11
0.15
1.4
1.2
—
—
—
0
0
776
7809
0.97
0.12
75.1
21.8
7.2
6.9
e9/l
0.23
751
7473
776
7808
0.97
0.12
75.8
21.9
108.0
133.9
g/l
177.13
756
7602
776
7807
0.97
0.11
75.1
21.8
3.5
4.4
e12/l
146.96
747
7466
776
7807
0.97
0.11
74.7
21.7
31.3
30.5
pg
13.73
760
7603
776
7806
0.98
0.11
75.3
21.8
190.1
237.2
e9/l
20.21
749
7504
776
7805
0.98
0.11
74.9
21.7
95.5
91.7
fl
32.87
759
7599
6
58
1.03
0.08
1.3
1.7
—
—
—
0
0
5
63
0.79
0.08
27.8
13.3
—
—
—
0
0
7
67
1.05
0.08
1.1
1.4
—
—
—
0
0
260
2634
0.98
0.07
3.7
3.2
6.8
7.3
mmol/l
0.99
215
2189
271
2744
0.98
0.07
4.4
4.0
14.0
7.9
mg/mmol
0.69
182
1778
10
91
1.10
0.04
2.4
1.8
—
—
—
0
0
18
190
0.95
0.04
4.4
3.4
41.7
27.5
mg/l
0.53
11
125
25
241
1.04
0.02
2.4
2.3
239.8
113.7
ug/min
0.48
11
143
257
2583
0.99
0.02
3.8
3.2
1912.9
198.8
mg/l
2.07
190
1674
753
7521
1.00
0.01
28.3
9.1
27.0
24.1
u/l
0.43
729
7118
11
106
1.04
0.00
1.4
1.9
174.3
211.1
pmol/l
1.02
11
98
10
99
1.01
0.00
1.8
2.7
—
—
—
0
0
10
99
1.01
0.00
1.4
1.8
—
—
—
0
0
19
185
1.03
0.00
1.8
2.6
—
—
—
0
0
8
82
0.98
0.00
1.6
1.4
—
—
—
0
0
8
82
0.98
0.00
1.6
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
19.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
8
83
0.96
0.00
1.6
1.3
—
—
—
0
0
8
81
0.99
0.00
1.3
1.2
—
—
nmol/l
—
0
0
8
83
0.96
0.00
1.6
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
8
79
1.01
0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
1.8
—
0
9

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_MYELODYSP_SYNDR_EXALLC – Myelodysplastic syndrome, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).