Allergic purpura

D3_ALLERGPURPURA

Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D69.0
  • Hospital discharge: ICD-9 2870
  • Hospital discharge: ICD-8 2870
  • Cause of death: ICD-10 D69.0
  • Cause of death: ICD-9 2870
  • Cause of death: ICD-8 2870

2 out of 7 registries used, show all original rules.

1181

4. Check minimum number of events

None

1181

5. Include endpoints

None

1181

6. Filter based on genotype QC (FinnGen only)

1181

Control definitions (FinnGen only)

Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Purpura allergica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11658 5675 5938
Only index persons 10225 5070 5155
Unadjusted period prevalence (%)
Whole population 0.16 0.16 0.17
Only index persons 0.19 0.19 0.20
Median age at first event (years)
Whole population 19.15 23.45 14.73
Only index persons 18.96 23.33 14.66

-FinnGen-

Key figures

All Female Male
Number of individuals 1181 691 490
Unadjusted period prevalence (%) 0.23 0.24 0.22
Median age at first event (years) 39.68 34.31 47.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1071
Matched controls
10708
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.0
ICD-10 Finland
Allergic purpura
16384.0
323.0
789
*
28700
ICD-8 Finland
Purpura and other haemorrhagic conditions, Allergic purpura
+∞
161.6
151
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
122.3
115
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.2
98.0
263
462
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
127.8
97.9
104
9
2870A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Allergic purpura[PURPURA HENOCH-SCHÖNLEIN]
+∞
90.9
86
*
H02AB06
ATC
prednisolone; systemic
3.2
69.6
614
3188
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
68.0
66.4
76
12
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
51.0
48.5
58
12
L95.8
ICD-10 Finland
Other vasculitis limited to skin
104.8
46.2
50
5
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
+∞
43.0
41
*
M36.4*D69.0
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
423.2
41.4
41
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
207.5
39.1
40
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
14.1
34.4
59
44
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
62.0
31.2
36
6
L04AX01
ATC
azathioprine; systemic
5.2
30.3
98
203
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
29.8
338
1764
J04BA02
ATC
dapsone; oral
45.1
28.8
35
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
27.3
183
705
D07AC01
ATC
betamethasone; topical
2.1
26.3
385
2230
D69
ICD-10 Finland
Purpura and other haemorrhagic conditions
266.7
25.8
26
*
C03CA01
ATC
furosemide; systemic
2.3
25.3
274
1378
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
66.5
22.9
26
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
22.7
142
520
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
22.4
438
2802
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
21.9
21
*
A02BC02
ATC
pantoprazole; systemic
1.9
20.8
643
4792
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
49.0
20.2
24
5
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.3
19.4
74
183
H02AB07
ATC
prednisone; oral
2.5
18.8
167
749
L95.0
ICD-10 Finland
Livedoid vasculitis
193.2
18.6
19
*
R23.3
ICD-10 Finland
Spontaneous ecchymoses
7.5
18.4
43
59
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.6
17.9
82
238
E0000UV
ATC
NA
1.8
17.2
432
2942
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
16.6
202
1050
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.5
16.3
48
90
H02AB04
ATC
methylprednisolone; systemic
2.3
15.5
156
744
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.1
15.2
41
69
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
15.1
154
737
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
14.9
119
502
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
14.9
270
1631
L04AA01
ATC
[U] ciclosporin; systemic
7.3
14.9
35
49
TK800
NOMESCO Finland
Hemodialysis
6.0
14.6
40
69
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.6
14.6
31
37
L04AA06
ATC
mycophenolic acid; systemic
6.6
14.5
37
58
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
14.2
111
462
L04AD01
ATC
ciclosporin; systemic
5.7
14.0
40
73
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
30.5
13.9
18
6
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.6
13.9
40
74
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.1
13.6
30
38
127
Kela drug reimbursment
Transplant complication
6.6
13.5
34
53
A12AA04
ATC
calcium carbonate; oral
7.0
13.2
32
47
N18.8
ICD-10 Finland
Other chronic renal failure
4.6
13.1
45
101
A46
ICD-10 Finland
Erysipelas
2.2
13.1
140
681
E000001
ATC
NA
1.9
13.0
230
1369
R50.9
ICD-10 Finland
Fever, unspecified
2.1
12.8
157
813
Z94.0
ICD-10 Finland
Kidney transplant status
8.0
12.6
28
36
A11CC03
ATC
alfacalcidol; systemic
5.1
12.6
39
79
A02BC01
ATC
omeprazole; systemic
1.8
12.4
259
1630
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
12.3
64
207
N02AX02
ATC
tramadol; systemic, rectal
1.6
12.2
383
2709
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
11.9
232
1422
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
11.7
361
2537
M36.4
ICD-10 Finland
Arthropathy in hypersensitivity reactions classified elsewhere
+∞
11.5
11
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
11.4
194
1134
R31
ICD-10 Finland
Unspecified haematuria
2.4
11.3
96
417
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
11.3
61
204
D07AB08
ATC
desonide; topical
2.1
11.0
128
649
D07AC13
ATC
mometasone; topical
1.7
10.7
272
1803
J01MA02
ATC
ciprofloxacin; systemic
1.6
10.7
351
2494
V03AE01
ATC
polystyrene sulfonate; oral
7.4
10.5
24
33
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
10.4
10
*
205
Kela drug reimbursment
Chronic hypertension
1.8
10.4
214
1330
TQW80
NOMESCO Finland
Local dermatologic skincare
4.2
10.3
38
93
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
10.3
62
223
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
23.6
10.3
14
6
M04AA01
ATC
allopurinol; systemic
2.1
9.9
110
547
E000006
ATC
NA
2.5
9.9
79
334
D68.8
ICD-10 Finland
Other specified coagulation defects
26.3
9.8
13
5
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
9.7
66
257
J01AA02
ATC
doxycycline; systemic
1.5
9.7
733
6269
P01BA02
ATC
hydroxychloroquine; oral
2.4
9.5
82
361
ZX120
NOMESCO Finland
Intravenous
2.2
9.5
95
451
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
4.7
9.4
31
68
137
Kela drug reimbursment
Uraemia requiring dialysis
7.6
9.4
21
28
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
100.9
9.4
10
*
J01DA01
ATC
[U] cefalexin; systemic
1.5
9.3
617
5098
B03XA02
ATC
darbepoetin alfa; parenteral
5.1
9.3
28
56
C03DA01
ATC
spironolactone; oral
2.2
9.3
94
448
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.2
9.2
93
441
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
13.8
9.2
15
11
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.0
9.2
28
57
C08CA01
ATC
amlodipine; oral
1.6
9.1
271
1867
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
9.1
9.0
18
20
B01AA03
ATC
warfarin; systemic
1.8
8.8
153
899
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.2
8.8
26
51
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.8
194
1228
R80
ICD-10 Finland
Isolated proteinuria
7.3
8.8
20
28
J01DB01
ATC
cefalexin; oral
1.6
8.7
830
7368
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.3
8.7
43
136
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
4.6
8.7
29
65
M31.3
ICD-10 Finland
Wegener granulomatosis
50.4
8.7
10
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.0
8.6
49
169
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
8.6
63
256
R06AE07
ATC
cetirizine; oral
1.5
8.6
438
3401
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
8.6
118
636
L01AA01
ATC
cyclophosphamide; systemic
16.4
8.6
13
8
J01MA12
ATC
levofloxacin; systemic
1.8
8.6
165
1001
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
27.7
8.5
11
*
E000002
ATC
NA
1.9
8.5
123
677
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
90.7
8.4
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.3
125
698
A41.9
ICD-10 Finland
Sepsis, unspecified
3.2
8.3
42
136
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
8.1
63
264
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
8.1
86
419
J01FF01
ATC
clindamycin; systemic
1.6
8.1
249
1722
TK820
NOMESCO Finland
Peritoneal dialysis
17.3
8.1
12
7
C09AA02
ATC
enalapril; systemic
1.8
8.1
156
948
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
6.6
7.9
19
29
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
7.9
89
446
B05DA
ATC
Isotonic solutions
8.5
7.8
16
19
V03AE02
ATC
sevelamer; oral
10.9
7.8
14
13
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.8
201
1328
J01CA04
ATC
amoxicillin; systemic
1.5
7.7
838
7522
D68.9
ICD-10 Finland
Coagulation defect, unspecified
45.3
7.7
9
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
7.7
100
530
M10.9
ICD-10 Finland
Gout, unspecified
2.5
7.6
56
229
J01FA06
ATC
roxithromycin; oral
1.5
7.6
376
2885
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
8.9
7.6
15
17
M05BA04
ATC
alendronic acid; oral
2.2
7.5
70
323
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
7.5
138
826
D07AA02
ATC
hydrocortisone; topical
1.7
7.5
151
929
N18.0
ICD-10 Finland
End-stage renal disease
6.5
7.4
18
28
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
6.5
7.4
18
28
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
6.5
7.4
18
28
C07AB07
ATC
bisoprolol; oral
1.5
7.4
362
2770
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
7.3
7
*
Z49.2
ICD-10 Finland
Other dialysis
9.4
7.3
14
15
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
7.2
92
482
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
7.2
70
329
E000007
ATC
NA
2.4
7.2
60
263
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
7.2
162
1030
M05BA01
ATC
etidronic acid; systemic
20.2
7.1
10
5
D07AD01
ATC
clobetasol; topical
1.8
7.1
133
798
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.1
74
357
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
7.1
36
118
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
10.1
7.0
13
13
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
7.0
80
401
D09AB01
ATC
zinc bandage without supplements; topical
4.0
7.0
26
66
B03XA01
ATC
erythropoietin; parenteral
5.5
6.9
19
35
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
6.9
250
1788
XW000
NOMESCO Finland
Bone marrow biopsy
2.9
6.8
39
136
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
11.0
6.8
12
11
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
6.7
254
1833
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.7
208
1433
M30.0
ICD-10 Finland
Polyarteritis nodosa
22.7
6.7
9
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
6.6
71
352
N03AX16
ATC
pregabalin; oral
1.6
6.5
192
1309
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.5
507
4201
L30.3
ICD-10 Finland
Infective dermatitis
3.1
6.5
33
109
S97
ICPC
Chronic ulcer skin
2.5
6.5
47
193
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.7
6.5
40
150
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
70.3
6.4
7
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.9
6.4
24
62
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.4
156
1014
C02AC05
ATC
moxonidine; oral
2.7
6.3
39
146
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.8
6.3
37
134
2870X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Allergic purpura[PURPURA ALLERGICA NUD]
+∞
6.3
6
*
126
Kela drug reimbursment
Chronic coagulation defects
+∞
6.3
6
*
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
6.3
6
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.2
405
3242
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
6.2
66
325
M13.9
ICD-10 Finland
Arthritis, unspecified
2.1
6.2
68
339
WX892
NOMESCO Finland
Monitored bed care
2.0
6.1
71
360
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.2
6.0
57
265
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.6
6.0
25
71
Z49.0
ICD-10 Finland
Preparatory care for dialysis
6.1
6.0
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
231
360
7.73
147.06
1.8
1.5
17.4
9.1
u/ml
—
9
11
168
287
6.66
96.63
1.7
1.5
0.2
0.2
g/l
0.32
156
276
168
299
6.38
92.67
1.7
1.5
1.2
1.2
g/l
0.35
156
285
149
352
4.70
59.13
1.3
1.2
—
—
—
0
0
315
1310
2.92
52.69
1.5
1.3
457.0
471.1
titre
0.05
61
253
205
709
3.29
46.84
10.4
7.1
9.7
9.0
mmol/l
0.71
194
672
529
3075
2.30
41.94
8.4
5.9
—
—
—
0
0
257
1102
2.70
39.39
10.2
5.6
1.1
1.1
mmol/l
1.45
241
1020
129
371
3.78
38.91
1.3
1.2
2.5
1.4
u/ml
0.19
11
23
694
4720
2.14
34.92
9.0
5.8
0.0
0.0
e9/l
1.93
628
4098
691
4697
2.14
34.75
9.0
5.8
0.6
0.6
e9/l
3.19
628
4074
71
142
5.26
33.98
1.5
1.4
—
—
—
0
0
706
4882
2.11
33.37
9.5
6.1
0.2
0.2
e9/l
0.32
647
4317
642
4293
2.09
33.12
9.5
5.9
0.7
0.7
%
0.14
614
4021
701
4857
2.09
32.67
9.1
5.8
2.1
2.0
e9/l
0.48
644
4307
655
4463
2.05
31.51
9.6
6.1
8.4
8.5
%
0.09
624
4204
649
4436
2.03
30.61
9.4
5.8
2.7
2.8
%
0.64
620
4150
659
4562
2.01
29.60
9.1
5.7
58.1
56.7
%
2.23
630
4295
663
4616
1.99
29.11
9.4
5.9
27.6
28.7
%
1.64
633
4330
746
5428
2.02
28.68
11.3
8.5
4.4
4.0
e9/l
3.35
679
4741
137
497
2.99
28.25
1.8
2.3
—
—
—
0
0
387
2262
2.06
27.59
4.9
3.3
557.5
256.0
mg/l
0.60
294
1462
382
2232
2.05
27.19
5.0
4.0
—
—
—
0
0
145
558
2.82
26.80
1.7
1.7
1.1
1.5
g/l
1.43
126
513
100
310
3.43
26.76
1.5
2.1
1.6
1.5
g/l
0.63
86
274
47
81
6.00
26.33
1.3
1.1
86.0
107.9
titre
—
10
14
433
2676
1.98
26.08
5.5
3.1
40.4
88.6
e6/l
1.07
344
2039
151
605
2.72
25.81
1.9
2.7
66.9
66.9
g/l
0.03
143
549
397
2391
1.99
25.68
6.2
4.1
20.6
9.3
mg/mmol
2.74
308
1533
190
855
2.46
25.55
3.3
2.6
1.9
1.7
%
0.95
172
763
396
2414
1.96
24.52
5.2
3.0
0.4
0.4
e6/l
0.14
301
1793
100
331
3.21
24.05
5.4
3.5
0.4
0.2
g/l
0.76
64
138
151
627
2.61
23.97
6.4
4.2
115.9
81.8
ng/l
2.30
137
560
488
3212
1.88
23.79
6.5
3.6
42.0
91.2
e6/l
1.53
362
2200
162
699
2.53
23.75
3.2
2.6
10.7
10.4
g/l
0.26
146
636
389
2380
1.95
23.67
5.0
3.0
—
—
—
0
0
254
1332
2.16
23.66
3.7
2.3
12.3
13.8
umol/l
2.70
242
1231
33
44
7.69
23.43
1.4
1.6
—
—
—
0
0
224
1123
2.23
23.33
4.0
2.4
21.6
23.8
%
1.37
197
973
420
2652
1.91
23.13
5.3
3.3
7.8
8.0
mmol/l
0.26
376
2255
531
3627
1.84
22.72
7.8
4.6
35.0
36.2
g/l
4.95
500
3373
144
608
2.56
22.03
2.9
2.4
76.1
70.7
e9/l
0.82
110
460
545
3795
1.81
21.53
9.2
5.8
1.2
1.2
mmol/l
0.36
512
3449
231
1220
2.11
20.90
3.9
2.3
2.3
2.4
g/l
0.57
219
1127
369
2320
1.86
20.03
8.2
6.2
—
—
—
0
0
813
6460
1.83
19.87
7.1
4.0
—
—
—
0
0
256
1440
1.99
19.36
3.9
2.7
0.8
1.0
e6/l
0.67
150
795
306
1829
1.91
19.34
4.5
2.5
4.6
6.5
e6/l
1.67
280
1604
293
1729
1.92
19.24
4.9
2.7
535.2
556.6
mosm/kgh2o
0.96
260
1483
345
2163
1.84
18.68
3.2
2.5
2928.0
6803.4
umol/l
1.12
308
1908
578
4221
1.72
18.37
10.9
6.4
1.2
1.2
mmol/l
0.14
500
3587
23
7
33.47
18.00
1.2
1.1
—
—
—
0
0
381
2490
1.78
17.82
7.2
3.8
7.4
7.4
ph
1.37
71
462
226
1257
1.99
17.49
3.0
2.0
29.8
29.5
s
0.20
217
1214
35
69
5.20
17.01
1.2
1.1
—
—
—
0
0
233
1325
1.94
16.86
2.0
1.6
—
—
—
0
0
74
253
3.05
16.83
1.7
2.5
10.8
10.0
g/l
0.77
64
219
140
659
2.28
16.70
5.1
3.3
—
—
—
0
0
828
6793
1.73
16.15
6.3
3.9
14.2
10.8
mm/h
7.33
786
6302
324
2072
1.78
16.04
5.0
3.5
—
—
—
0
0
238
1384
1.90
16.03
4.4
2.9
2.9
2.3
e6/l
0.35
130
742
324
2078
1.77
15.86
1.6
1.4
3.0
2.3
g/l
8.34
213
1302
609
4636
1.65
15.59
5.2
3.4
0.0
0.0
estimate
0.00
112
883
613
4692
1.64
15.21
5.2
3.4
0.0
0.0
estimate
0.80
118
868
836
6927
1.71
15.18
10.6
7.0
78.0
76.9
u/l
0.34
799
6514
608
4649
1.63
15.11
7.2
4.6
0.0
0.0
estimate
0.50
118
900
755
6105
1.66
14.91
5.4
4.2
658.3
2218.7
e6/l
0.85
12
92
226
1326
1.87
14.70
4.2
3.4
0.8
0.8
mmol/l
4.59
213
1241
27
48
5.73
14.65
1.2
1.1
398.8
157.5
iu/ml
1.36
27
48
558
4205
1.62
14.50
12.6
8.7
0.0
0.0
e9/l
0.32
464
3426
164
870
2.03
14.33
2.4
2.0
337.2
375.5
nmol/l
1.80
151
808
63
218
3.00
14.05
1.8
2.6
37.8
38.1
g/l
0.12
58
190
509
3790
1.60
13.64
2.9
2.3
74.8
74.9
nmol/l
0.03
478
3436
160
857
2.00
13.59
1.5
1.5
—
—
—
0
0
192
1100
1.89
13.36
2.2
1.6
—
—
—
0
0
30
64
4.78
13.35
1.3
2.2
—
—
—
0
0
309
2060
1.68
12.74
2.0
1.8
1.0
1.0
mg/l
0.08
234
1527
443
3257
1.58
12.15
11.4
7.7
1.2
1.2
inr
0.05
135
1000
290
1935
1.66
11.80
1.9
1.7
—
—
—
0
0
137
730
1.99
11.76
4.6
4.4
1.8
1.0
%
0.90
46
208
205
1250
1.77
11.56
2.1
2.0
—
—
—
0
0
62
237
2.71
11.54
1.3
1.2
1.6
2.8
u/ml
—
8
29
32
83
3.93
11.15
2.0
2.5
0.9
1.3
e9/l
0.91
18
44
45
147
3.14
11.10
1.3
1.6
—
—
—
0
0
43
137
3.22
11.05
1.5
1.4
0.8
0.6
g/l
0.41
32
106
638
5179
1.50
10.59
5.7
4.6
6.5
6.6
mmol/l
0.74
605
4793
129
699
1.95
10.53
4.6
4.5
0.2
0.1
%
0.15
44
192
45
152
3.04
10.51
1.3
1.2
3.3
4.4
u/ml
0.40
20
61
573
4561
1.50
10.39
7.2
5.7
10.6
11.0
umol/l
0.41
550
4319
326
2303
1.57
10.30
2.9
2.1
3.0
2.9
mg/l
0.16
290
1970
361
2616
1.55
10.17
3.5
2.8
—
—
—
0
0
60
241
2.57
10.15
4.0
3.2
—
—
—
0
0
126
696
1.91
9.71
8.9
8.5
—
—
—
0
0
60
247
2.51
9.66
1.7
2.5
10.2
11.7
mg/l
0.76
52
227
51
196
2.67
9.43
2.0
1.4
111.7
103.6
u/ml
0.37
14
33
53
208
2.62
9.41
1.9
1.5
—
—
—
0
0
24
57
4.28
9.40
1.2
1.0
—
—
—
0
0
345
2515
1.53
9.31
2.2
2.1
213.7
259.9
u/l
0.36
325
2380
221
1454
1.64
9.28
1.8
1.7
1221.6
1189.6
nmol/l
0.22
174
1114
120
663
1.90
9.24
4.5
4.3
1.4
0.5
%
1.09
33
158
557
4479
1.46
9.20
3.7
2.7
124.3
106.1
ug/l
0.94
527
4173
25
63
4.03
9.08
1.8
2.3
12.4
13.1
%
0.12
12
35
29
82
3.60
8.99
1.3
1.3
0.4
0.4
g/l
0.05
22
57
29
82
3.60
8.99
1.3
1.3
5.5
6.3
g/l
0.80
22
59
29
82
3.60
8.99
1.3
1.3
2.5
2.7
g/l
0.27
22
58
307
2201
1.53
8.89
6.2
4.4
—
—
—
0
0
106
572
1.94
8.76
5.7
3.5
7.4
7.4
ph
—
6
62
237
1609
1.59
8.71
1.3
1.3
24.5
30.8
iu/ml
0.61
70
502
86
435
2.05
8.52
6.6
4.1
24.0
24.0
mmol/l
0.01
81
399
118
667
1.85
8.46
4.6
4.6
0.1
0.7
%
0.52
38
163
133
787
1.78
8.21
7.2
3.7
1.7
1.8
mmol/l
0.10
110
632
54
230
2.41
8.12
1.4
1.3
243.8
248.6
u/ml
0.04
36
137
136
813
1.76
8.11
7.2
3.7
—
—
—
0
0
378
2877
1.46
8.04
4.5
3.2
2.3
2.4
mmol/l
0.27
337
2543
32
104
3.13
8.02
1.2
1.3
—
—
—
0
0
28
84
3.39
7.96
1.3
1.4
—
—
—
0
0
143
876
1.72
7.82
6.3
8.3
0.5
1.2
mmol/l
1.27
114
697
326
2423
1.48
7.79
2.2
2.0
—
—
—
0
0
84
436
2.00
7.77
6.5
3.5
—
—
—
0
0
50
210
2.44
7.76
1.8
3.7
30.8
30.9
mg/l
0.01
44
165
151
943
1.69
7.69
24.9
22.7
1.3
1.2
inr
0.21
14
141
131
791
1.74
7.54
3.1
2.3
0.2
0.2
g/l
2.34
124
740
82
429
1.98
7.43
1.4
1.3
—
—
—
0
0
66
319
2.13
7.39
3.1
2.3
21.1
21.3
s
0.24
59
285
49
210
2.39
7.29
1.9
3.7
41.5
83.9
mg/l
0.73
43
166
24
69
3.53
7.29
1.9
2.4
377.3
531.4
e6/l
0.80
18
56
141
877
1.69
7.29
6.4
8.3
4.9
5.1
kpa
2.64
136
838
31
105
3.01
7.27
2.4
2.2
—
—
—
0
0
364
2795
1.44
7.25
2.9
2.5
55.8
56.4
u/l
0.12
337
2599
23
65
3.59
7.16
1.9
2.4
0.2
0.2
e9/l
0.03
18
55
31
108
2.92
6.93
1.4
1.6
—
—
—
0
0
31
108
2.92
6.93
1.4
1.6
—
—
—
0
0
31
108
2.92
6.93
1.4
1.6
—
—
—
0
0
31
108
2.92
6.93
1.4
1.6
—
—
—
0
0
285
2115
1.46
6.74
3.5
3.2
1664.0
1233.2
ng/l
0.74
242
1773
1030
9568
1.60
6.70
21.5
12.4
20.4
22.2
mg/l
1.17
879
7455
132
830
1.66
6.55
2.4
2.4
34.4
94.2
u/l
0.52
120
699
398
3176
1.38
6.15
4.3
3.4
32.1
36.4
ng/l
0.31
273
1977
424
3423
1.37
6.09
2.0
1.9
94.3
95.9
pmol/l
0.32
238
1793
37
152
2.48
6.07
6.1
2.6
—
—
—
0
0
34
134
2.58
6.07
1.2
1.2
—
—
—
0
0
32
123
2.65
6.00
3.6
3.0
1.5
1.4
%
0.01
24
102
38
159
2.44
6.00
1.1
1.1
—
—
—
0
0
14
31
4.56
5.99
1.2
1.2
—
—
—
0
0
157
1055
1.56
5.93
1.7
1.4
—
—
—
0
0
48
227
2.16
5.74
1.3
1.3
—
—
—
0
0
25
87
2.91
5.64
4.0
3.5
—
—
—
0
0
186
1318
1.49
5.48
2.5
2.5
99.5
121.7
ug/g
0.76
160
1046
16
43
3.76
5.38
1.1
1.5
—
—
—
0
0
14
34
4.16
5.37
6.2
5.5
—
—
—
0
0
104
653
1.65
5.21
1.4
1.2
201.4
243.3
u/ml
0.32
94
613
209
1533
1.44
5.15
1.3
1.3
12.9
13.3
u/ml
0.03
71
619
58
308
1.93
5.10
2.1
1.8
1.6
2.3
ug/l
0.22
49
269
13
31
4.23
5.10
1.1
1.0
—
—
—
0
0
1012
9491
1.46
4.96
22.8
13.8
139.4
139.6
mmol/l
2.22
992
9240
38
174
2.22
4.95
6.4
3.8
55.5
57.0
%
0.31
38
174
1014
9517
1.46
4.91
23.1
13.8
3.9
4.0
mmol/l
0.34
994
9245
13
32
4.10
4.90
1.0
1.0
—
—
—
0
0
22
78
2.86
4.83
2.5
2.8
60.1
54.4
%
0.47
13
56
12
28
4.32
4.83
1.8
2.3
195.7
252.7
e6/l
—
7
15
169
1208
1.47
4.76
1.3
1.2
—
—
—
0
0
39
184
2.16
4.73
4.2
3.3
2.1
2.5
mmol/l
0.36
31
119
70
405
1.77
4.73
7.9
11.6
—
—
—
0
0
311
2472
1.35
4.72
5.9
3.7
0.0
0.0
estimate
1.08
108
878
37
172
2.19
4.66
6.0
3.5
4.1
4.3
e9/l
0.27
37
172
104
672
1.60
4.66
1.3
1.4
—
—
—
0
0
82
500
1.69
4.61
4.3
5.7
—
—
—
0
0
37
173
2.18
4.60
1.1
1.1
—
—
—
0
0
38
181
2.14
4.52
4.2
2.9
—
—
—
0
0
212
1595
1.40
4.51
4.7
3.5
195.4
525.0
ng/l
1.81
153
1133
16
49
3.30
4.48
1.1
1.2
—
—
—
0
0
18
60
3.03
4.41
1.1
1.2
—
—
—
0
0
143
1006
1.48
4.36
3.0
2.4
8.5
7.8
umol/l
0.14
128
868
66
386
1.75
4.32
2.0
1.7
—
—
—
0
0
884
8171
1.33
4.21
23.8
15.0
13.8
13.5
%
4.50
872
8004
48
257
1.90
4.17
1.2
1.2
76.7
87.4
titre
—
9
23
77
475
1.66
4.17
7.1
10.0
94.7
94.3
%
0.34
77
470
260
2051
1.34
4.09
5.4
3.7
1.0
1.0
kg/l
0.23
45
277
21
80
2.65
4.08
3.9
3.0
—
—
—
0
0
11
28
3.96
3.98
2.6
2.1
—
—
—
0
0
53
298
1.82
3.97
2.7
2.7
—
—
—
0
0
24
101
2.40
3.83
3.9
3.3
—
—
—
0
0
293
2376
1.31
3.78
1.3
1.3
1.1
1.5
u/ml
0.42
86
639
32
155
2.09
3.69
2.0
1.4
—
—
—
0
0
30
142
2.14
3.67
1.6
1.7
—
—
—
0
0
6
6
10.04
3.50
1.0
1.0
—
—
—
0
0
11
31
3.57
3.48
1.1
1.9
—
—
—
0
0
18
69
2.63
3.48
1.8
1.5
17.0
33.1
%
1.92
13
51
82
542
1.55
3.39
1.3
1.2
—
—
—
0
0
62
389
1.63
3.20
2.5
2.3
—
—
—
0
0
8
15
5.36
3.19
1.0
1.1
—
—
—
0
0
15
55
2.75
3.16
1.0
1.1
—
—
—
0
0
18
73
2.49
3.13
2.5
2.2
760.3
780.5
e6/l
—
9
29
11
34
3.26
3.06
1.1
1.1
—
—
—
0
0
10
29
3.47
3.05
1.0
1.0
—
—
—
0
0
190
1494
1.32
3.03
3.4
2.9
2.5
2.4
mmol/l
1.70
168
1297
30
154
1.97
3.01
1.2
1.2
—
—
—
0
0
20
88
2.29
2.94
1.3
1.1
—
—
—
0
0
16
64
2.52
2.88
4.0
3.2
11.7
11.2
%
0.23
16
64
7
13
5.41
2.87
11.3
4.9
6.0
7.8
mmol/l
—
7
13
6
9
6.69
2.87
2.7
1.1
—
—
—
0
0
26
130
2.02
2.82
1.3
1.5
—
—
—
0
0
36
202
1.81
2.79
1.6
1.8
10015.7
15878.5
e6/l
0.70
27
154
31
166
1.89
2.78
1.7
3.8
—
—
—
0
0
133
1007
1.36
2.73
1.4
1.3
—
—
—
0
0
28
146
1.94
2.72
2.7
2.9
—
—
—
0
0
15
60
2.52
2.71
1.1
1.1
—
—
—
0
0
78
538
1.48
2.69
1.2
1.1
—
202.3
—
0
9
1052
10131
1.35
2.68
14.5
9.2
27.1
26.8
u/l
0.23
1033
9812
790
7361
1.22
2.66
4.2
3.9
14.6
14.6
pmol/l
0.08
733
6766
21
99
2.14
2.65
2.0
1.8
63.8
61.2
%
0.11
14
74
12
43
2.81
2.65
2.1
4.2
104.0
131.8
umol/l
—
6
24
19
86
2.23
2.64
1.3
1.5
1457.5
210932.7
e6/l
1.13
14
60
26
134
1.96
2.61
2.7
3.0
0.9
0.9
nmol/l
0.02
15
104
920
8724
1.25
2.55
5.1
4.6
1.8
2.1
mu/l
0.76
872
8092
314
2684
1.23
2.52
4.6
3.0
—
—
—
0
0
238
1975
1.26
2.50
1.7
1.5
20.3
20.6
nmol/l
0.12
216
1693
332
2858
1.22
2.49
3.0
2.2
—
—
—
0
0
259
2173
1.25
2.47
2.7
2.2
—
—
—
0
0
410
3608
1.21
2.46
2.2
2.0
—
—
—
0
0
17
76
2.25
2.45
1.4
1.2
—
—
—
0
0
89
644
1.41
2.42
2.5
2.7
4.8
4.1
e9/l
1.14
68
528
25
131
1.93
2.42
2.3
2.4
—
—
—
0
0
165
1317
1.29
2.37
1.5
1.5
—
—
—
0
0
21
105
2.02
2.31
2.0
1.5
—
—
—
0
0
14
59
2.39
2.29
4.4
2.9
—
—
—
0
0
482
4329
1.19
2.28
4.6
3.9
—
—
—
0
0
90
663
1.39
2.22
6.4
3.4
1.2
1.2
mmol/l
0.93
83
570
20
100
2.02
2.21
3.1
3.1
—
—
—
0
0
956
9144
1.24
2.21
20.5
13.0
40.0
40.2
%
0.32
730
7084
29
165
1.78
2.20
2.2
2.3
16.9
16.5
%
0.17
12
79
19
94
2.04
2.16
1.2
1.1
—
—
—
0
0
7
19
3.70
2.15
3.4
1.5
—
—
—
0
0
40
252
1.61
2.12
1.4
1.4
307.0
309.9
ug/g
0.03
24
143
46
301
1.55
2.08
4.7
4.6
—
—
—
0
0
87
645
1.38
2.08
2.5
2.3
4.8
7.4
ug/l
1.46
75
568
9
31
2.92
2.07
2.0
1.7
—
—
—
0
0
31
185
1.69
2.02
5.7
3.1
—
—
—
0
0
27
155
1.76
2.01
1.2
1.2
—
—
—
0
0
20
104
1.94
2.01
2.0
1.6
—
—
—
0
0
22
119
1.86
1.98
1.2
1.2
—
—
—
0
0
83
620
1.36
1.92
3.2
2.9
230.8
183.8
ng/l
0.54
74
563
103
798
1.32
1.87
6.9
3.9
—
—
—
0
0
1041
10094
1.26
1.86
19.2
11.4
—
—
—
0
0
6
17
3.54
1.84
3.7
1.6
—
—
—
0
0
10
40
2.51
1.84
1.1
1.9
28.7
29.3
umol/l
—
10
40
137
1106
1.27
1.83
1.2
1.2
—
—
—
0
0
661
6168
1.16
1.82
3.8
3.4
—
—
—
0
0
59
420
1.43
1.81
1.2
1.3
253.1
225.8
miu/ml
0.22
26
208
121
967
1.28
1.76
1.4
1.4
—
—
—
0
0
82
622
1.34
1.74
1.5
1.4
—
—
—
0
0
867
8277
1.18
1.73
6.0
5.1
39.0
39.0
mmol/mol
0.03
820
7760
5
13
3.86
1.71
1.0
1.1
—
—
—
0
0
103
810
1.30
1.70
1.2
1.2
—
—
—
0
0
16
82
1.96
1.70
1.4
1.3
31.5
32.0
g/l
0.04
16
70
8
31
2.59
1.66
1.3
2.6
—
—
—
0
0
14
69
2.04
1.65
1.4
1.5
—
—
—
0
0
92
717
1.31
1.63
1.8
2.2
13.0
13.0
nmol/l
0.01
76
650
18
98
1.85
1.62
1.5
1.3
30.6
43.4
mu/l
0.43
18
88
104
826
1.28
1.60
6.4
3.6
—
—
—
0
0
42
288
1.48
1.59
1.3
1.2
—
—
—
0
0
22
130
1.71
1.53
2.6
3.0
82.1
35.8
u/ml
0.33
22
120
77
591
1.32
1.53
1.3
1.2
—
—
—
0
0
7
27
2.60
1.51
1.6
1.2
—
—
—
0
0
43
300
1.45
1.51
1.3
1.1
—
—
—
0
0
14
72
1.96
1.49
1.3
1.2
—
—
—
0
0
10
45
2.23
1.46
1.0
1.1
—
—
—
0
0
59
441
1.36
1.41
1.0
1.1
—
—
—
0
0
40
280
1.44
1.39
3.4
4.2
1.2
1.4
mmol/l
0.38
40
274
204
1773
1.18
1.36
1.7
1.6
425.1
21739557.6
pmol/l
1.56
177
1518
55
726
0.75
1.33
1.5
1.4
—
—
—
0
0
5
18
2.78
1.28
1.0
1.2
—
—
—
0
0
9
44
2.05
1.27
5.6
2.5
—
—
—
0
0
5
19
2.64
1.21
3.4
1.8
—
—
—
0
0
13
71
1.84
1.19
3.8
1.8
—
—
—
0
0
165
1428
1.18
1.17
1.8
1.7
—
—
—
0
0
5
20
2.51
1.15
2.4
2.5
—
—
—
0
0
22
143
1.55
1.12
1.4
1.6
—
—
—
0
0
7
31
2.27
1.10
1.1
1.1
—
—
—
0
0
8
41
1.96
1.09
3.3
1.6
3.4
6.5
nmol/l
—
8
35
5
22
2.28
1.03
6.6
4.5
57.4
50.0
%
—
5
22
18
114
1.59
1.03
1.1
1.3
0.5
0.6
nmol/l
0.48
18
105
74
601
1.25
1.02
3.7
3.3
4.5
4.6
pmol/l
0.31
65
534
74
601
1.25
1.02
2.8
2.6
—
—
—
0
0
9
47
1.92
1.02
1.0
1.1
1957.3
1627.0
miu/ml
—
9
47
12
68
1.77
1.00
1.3
1.1
—
—
—
0
0
331
3584
0.89
0.98
2.6
2.5
—
—
—
0
0
7
36
1.95
0.97
1.3
1.1
—
—
—
0
0
9
51
1.77
0.94
1.4
3.2
—
—
—
0
0
27
193
1.41
0.91
2.1
2.0
—
—
—
0
0
12
71
1.70
0.89
1.3
1.1
—
—
—
0
0
12
71
1.70
0.89
1.1
1.0
317.2
291.8
mg/l
0.48
12
62
11
64
1.73
0.86
1.5
1.2
—
—
—
0
0
69
569
1.23
0.86
1.5
2.4
262.1
4985.7
u/l
4.17
22
229
8
45
1.78
0.84
1.1
1.6
1.3
1.2
nmol/l
—
8
34
16
105
1.53
0.82
1.1
1.3
—
—
—
0
0
51
413
1.25
0.77
5.2
3.1
—
—
—
0
0
256
2359
1.11
0.75
4.5
3.6
—
—
—
0
0
11
67
1.65
0.75
2.0
1.7
—
—
—
0
0
7
38
1.85
0.73
3.7
2.8
—
—
—
0
0
9
55
1.64
0.73
1.4
1.3
—
—
—
0
0
7
39
1.80
0.72
1.6
1.5
—
—
—
0
0
7
39
1.80
0.72
1.1
3.7
—
—
—
0
0
24
177
1.36
0.71
1.8
1.4
21.6
22.2
u/l
0.04
16
148
25
330
0.75
0.69
1.6
1.5
—
—
—
0
0
7
42
1.67
0.68
3.7
2.6
—
—
—
0
0
7
43
1.63
0.67
1.9
1.5
—
21.4
—
0
5
45
368
1.23
0.65
1.4
1.5
10.6
9.0
u/l
0.28
33
298
26
198
1.32
0.64
2.7
2.4
161.1
91.7
ug/min
0.40
17
120
72
621
1.17
0.60
1.3
2.1
—
—
—
0
0
22
165
1.34
0.60
1.1
1.1
—
—
—
0
0
25
322
0.77
0.60
1.6
1.4
—
—
—
0
0
11
72
1.53
0.59
25.9
11.8
0.6
0.6
mmol/l
0.28
11
65
25
321
0.77
0.59
1.6
1.4
—
—
—
0
0
22
166
1.33
0.59
1.1
1.1
13.6
5.2
u/ml
—
6
65
0
23
0.00
0.58
0.0
7.0
—
—
—
0
0
15
106
1.42
0.57
1.5
1.1
—
—
—
0
0
11
73
1.51
0.56
1.1
1.4
43.8
46.7
pmol/l
—
5
18
49
412
1.20
0.56
1.1
1.1
—
—
—
0
0
27
213
1.27
0.54
5.5
3.9
—
—
—
0
0
14
99
1.42
0.54
2.0
1.9
31.5
32.6
pg
0.34
14
99
23
178
1.30
0.53
2.1
2.3
129.0
130.9
g/l
0.15
15
134
14
100
1.40
0.52
5.3
2.6
—
—
—
0
0
35
288
1.22
0.50
1.5
2.9
—
—
—
0
0
1094
10837
1.13
0.49
30.1
18.1
134.1
136.3
g/l
5.48
1079
10699
1094
10837
1.13
0.49
30.1
18.0
7.2
6.7
e9/l
8.55
1074
10564
12
166
0.72
0.48
2.0
1.6
—
—
—
0
0
124
1132
1.11
0.47
1.6
1.8
—
—
—
0
0
63
551
1.15
0.47
1.3
1.4
19.4
24.1
iu/l
0.72
55
459
66
580
1.15
0.47
1.4
2.3
—
—
—
0
0
1093
10831
1.12
0.46
29.9
17.9
90.4
90.4
fl
0.20
1081
10699
1093
10831
1.12
0.46
29.9
17.9
30.1
30.2
pg
1.00
1081
10698
1092
10821
1.12
0.46
30.2
18.0
252.0
254.0
e9/l
0.43
1070
10574
5
85
0.59
0.45
1.2
1.4
1.4
1.4
nmol/l
—
5
76
1093
10833
1.12
0.45
30.0
17.9
4.5
4.5
e12/l
2.92
1071
10565
13
95
1.37
0.43
9.1
8.1
5.7
6.8
mmol/l
—
8
77
11
78
1.41
0.43
1.3
1.6
14.7
12.2
umol/l
0.61
11
72
273
2872
0.94
0.42
1.6
1.5
—
—
—
0
0
70
623
1.13
0.42
1.3
2.2
—
—
—
0
0
107
1170
0.91
0.42
1.2
1.3
—
—
—
0
0
902
9157
0.94
0.42
4.5
3.9
1.4
1.5
mmol/l
3.31
858
8536
10
70
1.43
0.41
1.2
1.2
—
—
—
0
0
21
261
0.80
0.41
1.7
1.9
7.3
5.2
iu/l
0.30
11
94
0
15
0.00
0.41
0.0
8.5
—
—
—
0
0
0
16
0.00
0.41
0.0
2.6
—
—
—
0
0
26
213
1.23
0.41
1.1
1.1
—
—
—
0
0
42
362
1.17
0.40
1.6
1.6
—
—
—
0
0
26
214
1.22
0.39
1.1
1.1
—
—
—
0
0
70
628
1.12
0.38
1.3
2.2
—
—
—
0
0
9
66
1.37
0.38
1.2
1.1
—
—
—
0
0
23
188
1.23
0.37
2.3
1.4
0.4
0.3
nmol/l
0.02
15
152
70
631
1.12
0.36
1.3
2.2
—
—
—
0
0
6
42
1.43
0.35
1.2
1.5
—
10.8
—
0
5
18
146
1.24
0.32
2.2
1.5
—
—
—
0
0
26
220
1.19
0.32
1.1
1.1
2.3
1.8
u/ml
—
10
100
19
156
1.22
0.31
1.0
1.1
294.2
92.7
iu/ml
—
9
39
910
9207
0.95
0.30
4.6
3.9
4.6
4.7
mmol/l
1.82
868
8627
55
497
1.11
0.29
1.4
2.3
—
—
—
0
0
11
140
0.78
0.28
1.4
1.2
—
—
—
0
0
38
427
0.89
0.27
1.5
3.1
—
—
—
0
0
8
65
1.23
0.27
1.4
1.2
7.0
6.6
mmol/l
—
8
60
9
77
1.17
0.24
2.7
2.6
—
—
—
0
0
65
600
1.09
0.24
2.0
1.6
—
—
—
0
0
6
85
0.70
0.24
11.0
15.3
651.2
811.9
nmol/l
—
6
80
5
38
1.32
0.23
2.4
1.2
—
—
—
0
0
242
2338
1.04
0.23
1.7
1.7
1.5
1.4
mmol/l
0.68
218
1997
5
39
1.28
0.23
1.4
1.8
—
—
—
0
0
27
305
0.88
0.22
1.4
1.3
—
—
—
0
0
18
210
0.85
0.22
5.0
3.7
22.9
27.6
mg/l
0.30
12
134
5
41
1.22
0.22
1.0
1.0
259.2
251.3
ng/l
—
5
24
5
41
1.22
0.22
1.0
1.0
1082.4
574.8
ng/l
—
5
24
26
229
1.14
0.21
1.1
1.1
6.3
8.8
u/ml
0.34
14
120
0
11
0.00
0.21
0.0
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.2
—
0
5
0
11
0.00
0.21
0.0
1.0
—
0.4
—
0
5
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
6188.3
—
0
12
5
43
1.16
0.21
1.2
1.3
141.2
153.4
nmol/l
—
5
43
0
14
0.00
0.20
0.0
4.6
—
—
—
0
0
79
743
1.07
0.20
4.5
4.3
7.1
22.8
ug/l
0.81
62
608
21
184
1.14
0.19
1.1
1.0
1.0
4.4
u/ml
—
6
68
860
8521
1.03
0.19
25.5
15.4
331.7
333.2
g/l
4.82
852
8468
6
53
1.13
0.18
1.0
1.2
—
—
—
0
0
929
9355
0.97
0.16
4.9
4.3
2.7
2.8
mmol/l
3.10
879
8708
8
69
1.16
0.16
1.1
1.2
—
—
—
0
0
8
72
1.11
0.16
1.8
1.3
—
73.5
—
0
6
8
73
1.10
0.15
1.0
1.0
—
—
—
0
0
6
77
0.78
0.15
1.2
1.8
5.7
6.5
mmol/l
—
6
54
245
2392
1.03
0.14
4.1
4.5
1.8
2.4
ug/l
1.78
220
2162
9
83
1.08
0.14
1.2
1.2
—
—
—
0
0
21
189
1.11
0.13
5.0
2.9
1.4
1.5
mmol/l
0.33
21
184
144
1400
1.03
0.11
2.7
2.8
0.7
0.7
ug/l
0.21
90
855
46
485
0.95
0.11
1.9
1.5
423.6
300.0
mu/l
0.79
40
434
19
208
0.91
0.10
1.2
1.3
—
—
—
0
0
7
84
0.83
0.07
1.0
1.7
—
—
—
0
0
8
90
0.89
0.06
1.3
1.9
—
—
—
0
0
27
256
1.06
0.06
1.2
1.1
0.5
2.3
u/ml
1.73
12
103
21
222
0.94
0.05
1.1
1.2
—
—
—
0
0
898
8958
1.01
0.04
4.9
4.0
5.8
5.8
mmol/l
0.06
839
8236
28
289
0.97
0.02
15.5
9.2
—
—
—
0
0
10
107
0.93
0.02
1.3
2.2
—
—
—
0
0
74
749
0.99
0.01
1.3
1.2
120.9
150.0
iu/ml
0.34
27
301
878
8789
1.00
0.01
4.1
3.5
1.4
1.3
mmol/l
3.59
833
8167
20
206
0.97
0.00
1.1
1.1
—
—
—
0
0
10
104
0.96
0.00
1.0
1.3
—
—
nmol/l
—
0
0
29
288
1.01
0.00
3.1
3.2
173.7
1131.5
u/ml
0.90
24
249
19
185
1.03
0.00
1.1
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
15.4
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
8
0.00
0.00
0.0
2.1
—
1.2
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
9.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.7
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
4.3
—
—
—
0
0
6
59
1.02
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
87.9
—
0
7
5
49
1.02
0.00
2.4
2.2
2.0
2.2
ug/l
—
5
41
5
49
1.02
0.00
1.2
2.0
8.0
9.1
mmol/l
—
5
41
0
9
0.00
0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
7
71
0.99
0.00
1.6
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_ALLERGPURPURA and mortality.

Females

Parameter HR [95% CI] p-value
D3_ALLERGPURPURA 1.684 [1.48, 1.91] < 0.001
Birth year 0.999 [0.99, 1.01] 0.726

During the follow-up period (1.1.1998 — 31.12.2019), 714 out of 4075 females with D3_ALLERGPURPURA died.

Males

Parameter HR [95% CI] p-value
D3_ALLERGPURPURA 2.061 [1.77, 2.4] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 715 out of 3988 males with D3_ALLERGPURPURA died.

Mortality risk

Mortality risk for people of age

years, who have D3_ALLERGPURPURA.

N-year risk Females Males
1 0.196% 0.383%
5 1.231% 2.411%
10 2.985% 5.958%
15 5.514% 11.65%
20 9.794% 19.138%

Relationships between endpoints

Index endpoint: D3_ALLERGPURPURA – Allergic purpura

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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