obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1545 |
4. Check minimum number of eventsNone |
1545 |
5. Include endpointsNone |
1545 |
6. Filter based on genotype QC (FinnGen only) |
1545 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E78
Similar endpoints
↥List of similar endpoints to
Mixed hyperlipidaemia
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9795 | 3468 | 6263 |
| Only index persons | 8546 | 3081 | 5465 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.10 | 0.17 |
| Only index persons | 0.17 | 0.11 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 57.21 | 62.08 | 54.43 |
| Only index persons | 56.64 | 61.35 | 53.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1545 | 549 | 996 |
| Unadjusted period prevalence (%) | 0.35 | 0.19 | 0.44 |
| Median age at first event (years) | 56.12 | 58.03 | 55.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1394
- Matched controls
- 13939
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
4645.8
323.0
981
7
E78.2
ICD-10 Finland
Mixed hyperlipidaemia
1041.2
270.1
256
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
7.3
236.5
744
1879
C10AA05
ATC
atorvastatin; oral
5.9
205.2
927
3510
103
Kela drug reimbursment
Diabetes, insulin-treated
6.0
198.8
765
2358
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
20.7
194.9
300
182
A10BA02
ATC
metformin; oral
5.6
185.6
765
2496
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
8.3
168.0
420
690
E66.00
ICD-10 Finland
Metabolic syndrome
13.6
165.0
302
277
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.3
164.5
666
2049
C10AX09
ATC
ezetimibe; oral
8.7
163.8
393
602
E78.21
ICD-10 Finland
Remnant hyperlipidemia
+∞
161.7
152
*
C10AA01
ATC
simvastatin; oral
4.7
157.7
945
4308
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
5.4
146.8
552
1518
C10AB05
ATC
fenofibrate; oral
36.2
143.4
186
59
I10
ICD-10 Finland
Essential (primary) hypertension
4.6
137.2
1089
6099
2722A
ICD-9 Finland
Disorders of lipoid metabolism, Mixed hyperlipidaemia
+∞
136.7
129
*
C10AA07
ATC
rosuvastatin; oral
4.7
134.1
595
1914
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
10.6
125.6
259
293
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
8.3
123.3
298
443
T90
ICPC
Diabetes non-insulin dependent
4.4
122.1
583
1974
A10AE04
ATC
insulin glargine; parenteral
7.1
122.0
331
585
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.4
121.7
565
1861
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
46.2
121.3
149
36
C10AB02
ATC
bezafibrate; oral
39.5
119.7
152
43
C01DA14
ATC
isosorbide mononitrate; oral
5.0
112.9
433
1158
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
7.8
109.6
275
428
205
Kela drug reimbursment
Chronic hypertension
3.7
106.9
656
2690
I25.2
ICD-10 Finland
Old myocardial infarction
7.6
102.4
259
405
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
7.6
102.0
259
407
81
HP
Angiography of the heart and coronary arteries
7.7
101.7
256
397
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.9
100.7
541
1960
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.9
95.1
499
1755
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
34.4
89.5
117
37
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.6
88.2
286
614
B01AC04
ATC
clopidogrel; oral
4.2
83.5
379
1150
C07AB07
ATC
bisoprolol; oral
3.0
80.8
851
4813
C03CA01
ATC
furosemide; systemic
3.2
80.6
576
2504
C10AA03
ATC
pravastatin; oral
6.2
75.5
221
413
A10AE05
ATC
insulin detemir; parenteral
7.4
74.5
188
286
SPAT1262
SPAT
Handing over of treatment supplies
3.5
74.1
420
1516
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
3.4
73.5
449
1717
E66.01
ICD-10 Finland
Obesity due to excess calories
7.0
72.8
192
311
A10BB12
ATC
glimepiride; oral
5.3
70.3
233
504
A10BH01
ATC
sitagliptin; oral
4.7
68.6
261
655
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
10.0
68.4
142
156
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
7.7
68.3
168
245
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
5.2
67.2
228
505
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
4.7
67.2
255
637
AN1
HP
Coronary angiography
4.1
66.2
293
849
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
8.1
65.9
156
214
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.6
65.7
356
1225
C10AA04
ATC
fluvastatin; oral
4.8
65.6
241
581
B04AB02
ATC
NA
14.5
65.6
113
84
C07AB02
ATC
metoprolol; systemic
3.1
63.8
441
1812
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
7.6
62.0
153
223
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
62.0
532
2505
C10AB04
ATC
gemfibrozil; oral
24.4
59.6
85
37
M04AA01
ATC
allopurinol; systemic
3.5
56.8
313
1076
C08CA01
ATC
amlodipine; oral
2.5
56.3
633
3437
A10BK03
ATC
empagliflozin; oral
4.9
54.2
193
445
B04AC02
ATC
NA
63.7
52.8
61
10
R07.4
ICD-10 Finland
Chest pain, unspecified
2.6
49.4
466
2255
160
Kela drug reimbursment
exenatide
12.4
49.0
90
77
C03DA01
ATC
spironolactone; oral
3.7
48.9
235
717
C09AA02
ATC
enalapril; systemic
2.7
48.7
404
1809
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
10.0
48.7
100
107
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
7.4
48.6
120
174
G47.3
ICD-10 Finland
Sleep apnoea
2.7
46.2
405
1865
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
7.9
46.1
109
148
E66.8
ICD-10 Finland
Other obesity
6.3
46.1
128
219
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.8
45.9
214
634
C09AA05
ATC
ramipril; oral
2.5
45.7
455
2247
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
7.1
45.2
115
174
A10BB01
ATC
glibenclamide; oral
5.6
45.2
139
270
A10BJ02
ATC
liraglutide; parenteral
10.2
44.9
91
95
C10AA02
ATC
lovastatin; oral
5.8
43.3
129
241
A10BX01
ATC
guar gum; systemic
5.8
42.0
124
229
XCK10
NOMESCO Finland
Photography of fundus of eye
3.4
41.7
221
723
B04AC04
ATC
NA
22.3
41.2
60
28
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
39.5
671
4210
B01AC06
ATC
acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)
6.1
39.2
111
194
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
6.8
38.6
101
159
82
HP
Single vessel balloon catheter extension
8.8
38.3
84
101
I50.9
ICD-10 Finland
Heart failure, unspecified
2.9
38.1
262
1024
A10BG03
ATC
pioglitazone; oral
8.1
37.8
87
113
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
4.6
37.8
140
333
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
4.7
36.4
129
293
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
10.6
36.1
71
70
4019X
ICD-9 Finland
Essential hypertension, Unspecified
6.2
36.1
101
174
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
5.1
36.0
118
246
N02AX02
ATC
tramadol; systemic, rectal
2.1
35.9
654
4172
H3600, E113
ICD-10 Finland
NA
13.4
35.9
63
49
E78.11
ICD-10 Finland
Other hypertriglyceridemia
49.2
35.8
43
9
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
7.1
35.8
90
134
I20.00
ICD-10 Finland
Unstable angina
6.4
35.6
97
161
I20.09
ICD-10 Finland
Unstable angina
4.3
35.6
139
348
B01AC07
ATC
dipyridamole; systemic
4.7
35.4
126
287
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
4.3
34.6
137
347
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
4.7
34.5
122
276
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
8.1
34.0
78
101
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.2
34.0
135
343
A10BX07
ATC
[U] liraglutide; parenteral
13.6
33.9
59
45
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
6.7
33.5
88
139
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
7.2
33.5
83
121
I20.99
ICD-10 Finland
Angina pectoris, unspecified
4.0
33.4
142
384
A10BJ06
ATC
semaglutide; parenteral
6.3
32.7
90
152
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
11.8
31.8
59
52
11
HP
Coronary artery bypass surgery
6.9
31.6
81
124
C02AC05
ATC
moxonidine; oral
4.8
31.4
109
242
I20.90
ICD-10 Finland
Angina pectoris, unspecified
5.3
31.3
100
202
H3601, E113
ICD-10 Finland
NA
9.8
31.3
64
68
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
8.6
31.2
69
84
XF402
NOMESCO Finland
ECG with work load test
2.9
31.1
210
804
A10AA02
ATC
NA
6.2
31.1
86
146
C08CA13
ATC
lercanidipine; oral
2.7
30.2
234
975
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
2.4
30.1
290
1360
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.0
29.4
125
337
H36.01
ICD-10 Finland
Diabetic maculopathy
13.5
29.3
51
39
162
Kela drug reimbursment
liraglutide
14.0
29.2
50
37
R06.0
ICD-10 Finland
Dyspnoea
2.2
29.0
370
1986
N18.8
ICD-10 Finland
Other chronic renal failure
6.1
28.9
81
140
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
4.6
28.6
102
233
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.5
28.5
144
449
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.4
28.3
63
78
E78.40
ICD-10 Finland
Familial combined hyperlipidaemia
+∞
28.2
27
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
7.9
27.7
64
84
A02BC02
ATC
pantoprazole; systemic
1.9
27.5
887
6717
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
7.6
27.4
65
89
M10.9
ICD-10 Finland
Gout, unspecified
3.3
27.2
144
465
N03AX16
ATC
pregabalin; oral
2.1
27.1
352
1893
E66.0
ICD-10 Finland
Obesity due to excess calories
15.0
27.1
45
31
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
3.8
27.1
120
336
177
Kela drug reimbursment
Insulin glargine 300 U / ml
7.6
26.9
64
88
B04AB01
ATC
NA
10.0
26.8
54
56
211
Kela drug reimbursment
Severe hereditary disorders of lipid metabolism (familial hypercholesterolaemia and type III dyslipoproteinemia)
25.3
26.7
37
15
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
26.5
427
2507
C07AG02
ATC
carvedilol; oral
3.4
26.5
134
418
T89
ICPC
Diabetes insulin dependent
5.6
26.3
79
149
I20.01
ICD-10 Finland
Unstable angina
5.6
26.1
78
146
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
26.0
284
1409
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
7.5
25.4
61
85
A10BX04
ATC
[U] exenatide; parenteral
12.9
25.4
45
36
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
25.4
250
1178
I50.0
ICD-10 Finland
Congestive heart failure
3.2
25.3
142
477
C09BA02
ATC
enalapril and diuretics; systemic
2.9
25.0
168
636
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.9
24.9
84
181
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.4
24.8
55
68
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
24.7
265
1302
A10BH05
ATC
linagliptin; oral
4.0
24.6
101
264
C03AA03
ATC
hydrochlorothiazide; oral
2.7
24.3
178
711
J01FF01
ATC
clindamycin; systemic
2.0
24.1
403
2385
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
23.7
171
677
H36.00
ICD-10 Finland
Diabetic background retinopathy
11.6
23.3
43
38
4100X
ICD-9 Finland
Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]
5.6
23.2
69
129
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
13.2
23.0
40
31
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.1
22.7
131
450
AN4
HP
Balloon angioplasty and drug eluding stent
4.7
22.5
78
173
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
3.8
22.4
99
276
E86
ICD-10 Finland
Volume depletion
35.7
22.1
28
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.9
22.0
55
82
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
7.1
21.9
54
79
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
21.5
327
1853
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.0
21.5
88
230
4120B
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,AHTAUTUNUT]
7.9
21.4
49
64
C10BA02
ATC
simvastatin and ezetimibe; oral, topical
9.4
21.4
44
48
A11CC03
ATC
alfacalcidol; systemic
7.4
21.4
51
71
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
21.3
530
3569
A10AE06
ATC
insulin degludec; parenteral
5.6
21.0
62
115
I25
ICD-10 Finland
Chronic ischaemic heart disease
3.5
20.9
102
309
C09CA01
ATC
losartan; oral
1.9
20.7
352
2079
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
20.4
437
2797
N05CF01
ATC
zopiclone; oral
1.8
20.3
450
2909
N02BE01
ATC
paracetamol; systemic, rectal
1.9
20.2
1154
9956
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
13.3
20.2
35
27
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
19.7
298
1681
A10BG02
ATC
rosiglitazone; oral
6.8
19.5
49
74
A10BK01
ATC
dapagliflozin; oral
3.8
19.4
85
236
N06AA09
ATC
amitriptyline; systemic
2.5
19.3
158
671
A10BD07
ATC
metformin and sitagliptin; systemic
3.3
19.3
100
318
N06AB04
ATC
citalopram; systemic
2.0
19.3
289
1620
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.4
19.2
96
297
E87.6
ICD-10 Finland
Hypokalaemia
12.0
18.8
34
29
2720X
ICD-9 Finland
Disorders of lipoid metabolism, Pure hypercholesterolaemia[HYPERCHOLESTEROLAEMIA ALIA]
+∞
18.8
18
*
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
9.5
18.7
38
41
N05BA04
ATC
oxazepam; oral
1.9
18.5
316
1858
B01AA03
ATC
warfarin; systemic
1.9
18.5
319
1881
R07.3
ICD-10 Finland
Other chest pain
2.6
18.5
147
612
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
7.6
18.5
43
58
TK800
NOMESCO Finland
Hemodialysis
6.2
18.3
49
81
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.7
18.2
80
223
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
18.0
524
3651
EBA00
NOMESCO Finland
Extraction of tooth
1.8
18.0
431
2831
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
8.5
18.0
39
47
E87.5
ICD-10 Finland
Hyperkalaemia
15.6
18.0
29
19
4120X
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]
6.3
18.0
48
79
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
5.3
17.8
55
108
A10AA01
ATC
NA
5.9
17.8
50
88
E66.9
ICD-10 Finland
Obesity, unspecified
5.0
17.7
57
118
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
14.8
17.6
29
20
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
17.6
190
927
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
13.3
17.5
30
23
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.1
17.5
99
335
I50.1
ICD-10 Finland
Left ventricular failure
3.2
17.3
94
309
A46
ICD-10 Finland
Erysipelas
2.1
17.3
220
1152
J01DA01
ATC
[U] cefalexin; systemic
1.6
17.3
807
6373
A12AA04
ATC
calcium carbonate; oral
8.6
17.2
37
44
C07AB08
ATC
celiprolol; oral
4.4
17.2
63
149
I20.91
ICD-10 Finland
Angina pectoris, unspecified
7.8
17.2
39
51
J01DB01
ATC
cefalexin; oral
1.7
17.1
1078
9238
C08CA02
ATC
felodipine; oral
2.4
17.0
160
727
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
16.8
112
422
H3603, E113
ICD-10 Finland
NA
11.3
16.8
31
28
SPAT1263
SPAT
Sampling
1.6
16.6
547
3920
H3601, E103
ICD-10 Finland
NA
16.5
16.6
26
16
C07AB03
ATC
atenolol; systemic
2.8
16.5
109
408
Z49.0
ICD-10 Finland
Preparatory care for dialysis
13.6
16.5
28
21
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.9
16.5
31
29
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
16.5
183
903
N19
ICD-10 Finland
Unspecified kidney failure
3.8
16.5
70
190
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
16.5
144
633
A10AB06
ATC
insulin glulisine; parenteral
11.3
16.3
30
27
N06AX11
ATC
mirtazapine; oral
1.7
16.2
396
2601
C02DE02
ATC
NA
6.4
16.2
42
67
C02EA02
ATC
NA
3.1
16.0
90
301
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.8
15.9
107
406
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
15.9
223
1212
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.0
15.9
92
317
R51.80
ICD-10 Finland
Headache
2.2
15.8
171
831
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
2.9
15.7
99
358
E78.10
ICD-10 Finland
Familial hypertriglyceridemia
+∞
15.6
15
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
15.6
605
4506
H3600, E103
ICD-10 Finland
NA
13.9
15.5
26
19
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
15.4
398
2653
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
15.3
209
1121
C08DB01
ATC
diltiazem; oral
2.8
15.3
99
367
FNC20
NOMESCO Finland
Aorto-coronary venous bypass with two distal anastomoses
4.7
15.2
51
111
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
18.0
15.2
23
13
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.6
15.1
52
116
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
15.0
227
1267
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.6
15.0
69
201
C03BA11
ATC
indapamide; oral
4.0
14.9
59
151
WX110
NOMESCO Finland
Local anesthesy
1.6
14.8
849
6928
C08CA07
ATC
nisoldipine; oral
6.6
14.7
37
57
N06AX21
ATC
duloxetine; oral
2.3
14.6
135
609
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.6
14.6
110
446
C08CA05
ATC
nifedipine; systemic
2.6
14.6
109
439
E78.49
ICD-10 Finland
Other hyperlipidaemia
12.0
14.6
26
22
N18.0
ICD-10 Finland
End-stage renal disease
8.2
14.6
32
40
5314
FHL
Bypass surgery for four or more vessels
9.0
14.5
30
34
280
Kela drug reimbursment
Clopidogrel
5.7
14.4
41
74
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
14.3
174
891
R42
ICD-10 Finland
Dizziness and giddiness
1.8
14.3
278
1692
A10BB07
ATC
glipizide; oral
6.0
14.3
39
67
E78.1
ICD-10 Finland
Pure hyperglyceridaemia
19.4
14.2
21
11
J01AA02
ATC
doxycycline; systemic
1.6
14.2
1018
8737
358
Kela drug reimbursment
liraglutide
14.6
14.1
23
16
G63.2
ICD-10 Finland
Diabetic polyneuropathy
14.6
14.1
23
16
C09CA06
ATC
candesartan; oral
1.8
14.0
285
1760
RD210
NOMESCO Finland
NA
6.0
14.0
38
65
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.1
13.9
76
252
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
13.9
461
3272
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
13.9
162
812
H02AB06
ATC
prednisolone; systemic
1.6
13.9
599
4538
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
5.9
13.8
38
66
R5140
NOMESCO Finland
Monitoring the use of the aid
2.1
13.8
160
804
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
13.8
334
2175
Z49.1
ICD-10 Finland
Extracorporeal dialysis
7.4
13.8
32
44
A10BD03
ATC
metformin and rosiglitazone; systemic
5.2
13.7
42
83
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
13.7
152
747
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
6.2
13.7
36
59
N06AB10
ATC
escitalopram; oral
1.9
13.6
218
1239
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
13.6
211
1186
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.5
13.6
63
185
B04AX03
ATC
NA
75.9
13.6
15
*
AA1AD
NOMESCO Finland
CT of head and brain
1.7
13.5
310
1985
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
4.5
13.5
47
107
111
HP
Conventional CABG
13.0
13.4
23
18
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
13.4
167
861
L28
ICPC
Limited function/disability (L)
1.9
13.3
214
1218
T82
ICPC
Obesity
4.0
13.3
53
137
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
13.3
325
2117
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
13.9
13.2
22
16
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
6.2
13.2
35
58
FN1BT
NOMESCO Finland
Extensive endovascular dilatation of coronary (PTCA) arteries
4.5
13.2
46
105
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
13.1
402
2789
AA1
HP
Conventional CABG
5.0
13.0
41
84
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
13.1
12.9
22
17
C10AC02
ATC
colestipol; oral
19.2
12.9
19
10
N06AX16
ATC
venlafaxine; oral
2.1
12.9
155
787
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
12.9
190
1047
3015
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
50.5
12.9
15
*
K02.1
ICD-10 Finland
Caries of dentine
1.5
12.8
651
5086
V03AE01
ATC
polystyrene sulfonate; oral
7.3
12.8
30
42
I20.80
ICD-10 Finland
Other angina pectoris no detected stenosis of coronary artery
5.5
12.7
37
69
A10BJ01
ATC
exenatide; parenteral
7.9
12.6
28
36
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.7
12.6
55
154
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
3.2
12.6
67
219
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
11.1
12.5
23
21
N05BA01
ATC
diazepam; systemic, rectal
2.0
12.5
178
966
61
HP
Catheterization and pressure measurement of the left side of the heart
4.8
12.5
41
88
H25.8
ICD-10 Finland
Other senile cataract
2.0
12.5
159
830
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
24.5
12.5
17
7
N03AX12
ATC
gabapentin; oral
1.9
12.4
198
1124
E66
ICD-10 Finland
Obesity
3.3
12.3
61
189
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.2
12.3
131
630
5315
FHL
Bypass surgery using a mammary artery
6.0
12.3
33
56
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
14.5
12.3
20
14
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
10.6
12.3
23
22
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
4.9
12.2
39
81
M10
ICD-10 Finland
Gout
2.8
12.2
77
282
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.8
12.2
211
1230
R53
ICD-10 Finland
Malaise and fatigue
1.8
12.2
236
1430
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.4
12.1
105
459
R03AC02
ATC
salbutamol; inhalant
1.5
12.1
615
4789
PE1AT
NOMESCO Finland
Femoral artery PTA
6.6
12.1
30
46
C09DA01
ATC
losartan and diuretics; oral
2.0
12.0
153
795
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
3.7
12.0
52
145
S97
ICPC
Chronic ulcer skin
2.6
11.9
86
341
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
11.9
318
2115
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.8
11.8
49
132
H03AA01
ATC
levothyroxine sodium; systemic
1.7
11.8
252
1572
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
4.6
11.8
40
89
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.0
11.8
165
891
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.3
11.8
59
185
M10.0
ICD-10 Finland
Idiopathic gout
3.2
11.7
60
191
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
11.7
157
834
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.5
11.7
95
403
UJF32
NOMESCO Finland
Coloscopy
1.6
11.6
343
2339
NHQ40
NOMESCO Finland
Amputation of toe
4.6
11.6
39
86
L17
ICPC
Foot/toe symptom/complaint
1.7
11.6
305
2019
C01BD01
ATC
amiodarone; systemic
3.4
11.5
54
161
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.0
11.5
65
220
C10AD06
ATC
acipimox; oral
+∞
11.5
11
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
11.4
168
925
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
11.4
147
770
FN1CB
NOMESCO Finland
Coronary flow reserve measurement with pressure wire
4.3
11.4
41
97
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
4.6
11.3
38
84
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.0
11.2
44
113
SPAT1229
SPAT
Assessment of need for aid
2.2
11.0
111
524
A06AD11
ATC
lactulose; oral
1.8
10.9
191
1117
A12BA01
ATC
potassium chloride; oral
2.7
10.9
73
278
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
10.9
612
4830
J01MA12
ATC
levofloxacin; systemic
1.7
10.9
254
1625
5313
FHL
Bypass surgery for three vessels
12.0
10.8
19
16
S18
ICPC
Laceration/cut
1.5
10.8
535
4110
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.5
10.7
49
144
CKC10
NOMESCO Finland
Local photocoagulation of retina
4.6
10.7
36
80
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
10.7
133
686
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
21.6
10.7
15
7
196
Kela drug reimbursment
Paricalcitol and cinacalcet
21.6
10.7
15
7
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
10.7
131
673
A02BC03
ATC
lansoprazole; oral
1.6
10.6
374
2660
N05AH04
ATC
quetiapine; oral
1.8
10.6
183
1065
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
5.3
10.6
31
59
A02BA02
ATC
ranitidine; systemic
1.7
10.6
259
1677
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
10.6
483
3639
C09CA03
ATC
valsartan; oral
2.0
10.6
134
696
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
5.1
10.5
32
64
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
10.5
555
4318
J01CA04
ATC
amoxicillin; systemic
1.5
10.4
981
8563
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
10.4
116
570
N06AA12
ATC
doxepin; systemic
2.5
10.4
80
329
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
2.7
10.4
70
268
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
10.4
114
559
4111X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Intermediate coronary syndrome[PITKITTYNYT ANGINA PECTORIS -KOHTAUS,MÄÄRITTELEMÄT]
6.1
10.3
27
45
I79.2*E11.5
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic peripheral angiopathy
10.7
10.3
19
18
N06AB06
ATC
sertraline; oral
2.1
10.3
115
568
H3603, E103
ICD-10 Finland
NA
9.6
10.3
20
21
N05CD07
ATC
temazepam; oral
1.8
10.2
180
1054
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
10.2
319
2199
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
10.2
110
535
I25.8
ICD-10 Finland
Other forms of chronic ischaemic heart disease
5.3
10.2
30
58
R05FB02
ATC
cough suppressants and expectorants
1.5
10.1
473
3573
N05BA12
ATC
alprazolam; oral
2.0
10.1
127
659
H04AA01
ATC
glucagon; nasal, parenteral
4.9
10.1
32
67
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
7.0
10.1
24
35
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
10.1
659
5336
AN3
HP
Balloon angioplasty and metallic stent
3.3
10.1
50
157
315
Kela drug reimbursment
Clopidogrel
6.5
10.0
25
39
FNE20
NOMESCO Finland
Coronary bypass using free arterial graft of radial artery
9.2
10.0
20
22
294
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
40.3
10.0
12
*
C10AX13
ATC
evolocumab; parenteral
40.3
10.0
12
*
I21.19
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
4.9
9.9
31
64
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
4.9
9.9
31
64
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
5.1
9.9
30
60
H05BX01
ATC
cinacalcet; oral
16.8
9.9
15
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.5
9.9
76
312
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
5.3
9.9
29
56
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
8.8
9.8
20
23
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.5
9.8
33
74
PH2CD
NOMESCO Finland
Very extensive CT of inferior vena cava, pelvic veins and veins of lower extremity
9.6
9.8
19
20
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
9.7
175
1035
40199
ICD-8 Finland
Essential benign hypertension
3.8
9.6
39
104
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.5
9.6
75
312
H02AB04
ATC
methylprednisolone; systemic
1.8
9.6
181
1085
Z94.0
ICD-10 Finland
Kidney transplant status
8.4
9.6
20
24
4140X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,MÄÄRITTELEMÄT]
8.4
9.6
20
24
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.0
9.5
55
191
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.3
9.5
88
400
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
3.7
9.5
40
111
WX722
NOMESCO Finland
PEEP
2.5
9.4
72
297
I50
ICD-10 Finland
Heart failure
3.1
9.4
50
165
M03BX02
ATC
tizanidine; oral
1.4
9.4
727
6042
E78.3
ICD-10 Finland
Hyperchylomicronaemia
+∞
9.4
9
*
207
Kela drug reimbursment
Chronic arrhythmias
1.7
9.4
200
1242
Z49.2
ICD-10 Finland
Other dialysis
12.4
9.4
16
13
321
Kela drug reimbursment
Paricalcitol and cinacalcet
21.8
9.4
13
6
M79.6
ICD-10 Finland
Pain in limb
1.5
9.3
405
3005
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
9.3
80
351
CKC15
NOMESCO Finland
Panretinal photocoagulation
7.0
9.3
22
32
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
2.9
9.3
54
189
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
9.3
118
613
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
3.9
9.2
36
93
M48.0
ICD-10 Finland
Spinal stenosis
1.8
9.2
164
965
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
9.2
837
7164
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
6.8
9.1
22
33
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
7.8
9.1
20
26
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.8
9.1
58
215
N02AA05
ATC
oxycodone; systemic
1.7
9.1
190
1174
A02BC05
ATC
esomeprazole; systemic
1.4
9.0
492
3818
212
Kela drug reimbursment
Gout
3.4
9.0
42
127
T92
ICPC
Gout
3.4
9.0
42
127
WX892
NOMESCO Finland
Monitored bed care
2.1
8.9
97
474
Z50.0
ICD-10 Finland
Cardiac rehabilitation
5.5
8.9
25
46
R06.5
ICD-10 Finland
Mouth breathing
2.0
8.8
117
621
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.9
8.8
52
185
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
8.8
638
5220
PD3YT
NOMESCO Finland
Pelvic artery PTA with stent
5.7
8.8
24
43
R05FA02
ATC
opium derivatives and expectorants; systemic
1.4
8.7
483
3753
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.5
8.7
311
2204
R55
ICD-10 Finland
Syncope and collapse
1.9
8.7
134
750
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
14.1
8.7
14
10
SPAT1097
SPAT
Recording of ECG
1.7
8.7
194
1222
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.8
8.7
163
974
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
8.7
352
2568
C09DA06
ATC
candesartan and diuretics; oral
2.1
8.7
97
480
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.1
8.6
103
521
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
8.6
207
1327
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
8.6
190
1189
EBA30
NOMESCO Finland
Excision of root of tooth
2.3
8.6
77
343
AN2
HP
Balloon angioplasty, including several vessels
2.9
8.6
51
182
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.5
8.6
63
255
SPAT1254
SPAT
Administration of medicine
1.7
8.6
172
1048
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
8.3
8.6
18
22
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.2
8.6
89
425
C02CA01
ATC
prazosin; oral
3.8
8.6
35
95
C01AA05
ATC
digoxin; systemic
1.9
8.5
119
643
M01AB01
ATC
indometacin; systemic, rectal
1.9
8.5
126
695
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
8.4
357
2626
E87.2
ICD-10 Finland
Acidosis
90.6
8.4
9
*
K05.31
ICD-10 Finland
Periodontitis pronounced
1.9
8.4
129
719
R11
ICD-10 Finland
Nausea and vomiting
2.2
8.4
86
410
C07AB05
ATC
betaxolol; oral
3.1
8.4
44
145
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.1
8.3
44
146
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.5
8.3
16
17
83
HP
Multi-vessel balloon catheter extension
9.5
8.3
16
17
C10AC01
ATC
colestyramine; oral
3.3
8.3
39
119
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.0
8.3
31
78
CKC12
NOMESCO Finland
Photocoagulation of retina
2.5
8.2
63
260
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
8.2
281
1968
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
5.0
8.2
25
51
V03AE02
ATC
sevelamer; oral
14.6
8.2
13
9
J01FA06
ATC
roxithromycin; oral
1.4
8.2
470
3666
FNC30
NOMESCO Finland
Aorto-coronary venous bypass with three distal anastomoses
3.7
8.2
34
94
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.1
575
4656
J01MA02
ATC
ciprofloxacin; systemic
1.4
8.1
503
3978
A41.9
ICD-10 Finland
Sepsis, unspecified
2.7
8.1
53
201
F32
ICD-10 Finland
Depressive episode
2.8
8.1
51
187
A28
ICPC
Limited function/disability NOS
1.7
8.1
185
1171
C07AA07
ATC
sotalol; systemic
2.5
8.1
63
264
N06AB03
ATC
fluoxetine; oral
1.8
8.1
141
824
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.5
8.1
302
2158
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
3.9
8.1
31
80
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.1
200
1295
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.1
180
1133
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
9.0
8.0
16
18
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
10.1
8.0
15
15
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
6.3
8.0
20
32
PEP25
NOMESCO Finland
Percutaneous plastic repair of superficial femoral artery
22.1
8.0
11
5
M54.5
ICD-10 Finland
Low back pain
1.5
8.0
360
2677
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
7.3
8.0
18
25
G51.0
ICD-10 Finland
Bell palsy
3.2
7.9
39
123
I21.00
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
4.2
7.9
28
67
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.9
132
759
SPAT1310
SPAT
Counselling related to known health issue
1.5
7.9
369
2766
Z50.1
ICD-10 Finland
Other physical therapy
2.3
7.9
72
324
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
13.1
7.9
13
10
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.3
7.9
37
113
A11
ICPC
Chest pain NOS
2.0
7.9
93
470
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.1
7.8
84
407
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
7.8
130
749
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
10.9
7.8
14
13
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.9
7.8
14
13
E83.50
ICD-10 Finland
Hypercalcemia
10.9
7.8
14
13
C09AA01
ATC
captopril; oral
3.2
7.8
39
125
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.0
7.8
95
488
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
7.8
135
788
P01AB01
ATC
metronidazole; oral, rectal
1.4
7.8
433
3353
A10AA03
ATC
NA
7.0
7.8
18
26
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
2.2
7.8
74
341
ACC51
NOMESCO Finland
Release of median nerve
2.1
7.7
84
412
I44.2
ICD-10 Finland
Atrioventricular block, complete
3.0
7.7
44
151
B04AC01
ATC
NA
15.1
7.7
12
8
N06AX03
ATC
mianserin; oral
2.4
7.7
63
270
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.1
7.7
83
403
5253
FHL
Cardiac lung machine
5.3
7.7
22
42
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
7.5
7.7
17
23
P29
ICPC
Psychological sympt/compl other
2.6
7.7
54
215
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.6
519
4163
E29.1
ICD-10 Finland
Testicular hypofunction
5.0
7.6
23
47
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
6.7
7.6
18
27
C09CA07
ATC
telmisartan; oral
2.0
7.6
96
502
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
11.9
7.6
13
11
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
7.6
470
3708
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.9
7.6
29
75
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
3.7
7.6
31
85
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.8
7.6
129
746
R52.9
ICD-10 Finland
Pain, unspecified
2.0
7.5
93
479
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
3.0
7.5
43
148
A02BC01
ATC
omeprazole; systemic
1.5
7.5
338
2508
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
7.5
82
403
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.1
7.5
39
129
127
Kela drug reimbursment
Transplant complication
4.9
7.5
23
48
M79.1
ICD-10 Finland
Myalgia
1.8
7.4
132
776
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
2.4
7.4
62
270
B01AC24
ATC
ticagrelor; oral
2.6
7.4
52
206
N08.3
ICD-10 Finland
Glomerular disorders in diabetes mellitus
80.5
7.4
8
*
4110X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Postmyocardial infarction syndrome[EPÄSTABIILI ANGINA PECTORIS,MÄÄRITTELEMÄT]
6.5
7.4
18
28
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
13.4
7.4
12
9
B01AF02
ATC
apixaban; oral
1.8
7.4
124
716
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
7.4
372
2825
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
2.2
7.3
71
329
QBJ30
NOMESCO Finland
Correction of abdominal apron
10.9
7.3
13
12
A08AB01
ATC
orlistat; oral
6.9
7.3
17
25
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.3
7.3
64
287
N17.8
ICD-10 Finland
Other acute renal failure
6.3
7.2
18
29
R06.2
ICD-10 Finland
Wheezing
2.5
7.2
54
222
Z72.0
ICD-10 Finland
Tobacco use
3.3
7.2
34
105
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.5
7.2
253
1784
K08.3
ICD-10 Finland
Retained dental root
2.0
7.2
90
467
E83.51
ICD-10 Finland
Hypocalcemia
30.2
7.1
9
*
SGB10
NOMESCO Finland
Fiiling of rooth of tooth with one root channel
1.7
7.1
144
877
27901
ICD-8 Finland
Other and unspecified metabolic diseases, Hyperlipaemia, hyperglyceridaemia non familiaris NUD
20.1
7.1
10
5
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
7.1
243
1700
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.1
7.1
36
117
M01AH02
ATC
rofecoxib; oral
1.7
7.1
163
1031
FN2AB
NOMESCO Finland
Percutaneous transluminal coronary angioplasty (PTCA), drug-eluting balloon
4.2
7.1
25
60
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.7
7.1
46
174
A10BD20
ATC
metformin and empagliflozin; systemic
5.1
7.1
21
42
FL1AC
NOMESCO Finland
Left cardioangiography
3.9
7.1
27
70
SPAT1211
SPAT
Application of soft bandage
1.9
7.1
105
580
R06AE07
ATC
cetirizine; oral
1.4
7.0
464
3691
B81
ICPC
Anaemia vit B12/folate deficiency
2.5
7.0
53
219
L04AA06
ATC
mycophenolic acid; systemic
4.2
7.0
25
61
WX290
NOMESCO Finland
Other blockade of nerve
1.4
7.0
447
3532
-50
ICPC
Medication/prescr/renewal
2.3
7.0
61
270
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
7.0
7.0
16
23
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
3.6
7.0
29
81
N30.0
ICD-10 Finland
Acute cystitis
1.7
7.0
133
801
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
5.9
6.9
18
31
R52.2
ICD-10 Finland
Other chronic pain
2.9
6.9
40
141
J01MA14
ATC
moxifloxacin; systemic
1.8
6.9
108
610
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
6.9
408
3179
2780A
ICD-9 Finland
Obesity and other hyperalimentation, Obesity
7.6
6.9
15
20
A01
ICPC
Pain general/multiple sites
2.0
6.9
84
432
H3602, E113
ICD-10 Finland
NA
13.8
6.9
11
8
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.9
6.9
40
142
A10BX02
ATC
repaglinide; oral
4.4
6.8
23
53
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.5
6.8
30
88
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.8
6.8
114
658
PC5DE
NOMESCO Finland
Ultrasound of kidney circulation with Doppler technic
11.0
6.8
12
11
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.3
6.8
60
269
I21.10
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
5.3
6.8
19
36
PE1YT
NOMESCO Finland
Femoral or popliteal artery PTA with stent
5.7
6.8
18
32
I15.2
ICD-10 Finland
Hypertension secondary to endocrine disorders
40.2
6.8
8
*
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.7
6.8
142
876
R73.0
ICD-10 Finland
Abnormal glucose tolerance test
3.0
6.7
36
122
SPAT1312
SPAT
General health counselling
1.4
6.7
354
2698
J20
ICD-10 Finland
Acute bronchitis
1.9
6.7
101
563
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
4.3
6.7
23
54
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
6.7
74
365
N06AX05
ATC
trazodone; oral
3.3
6.7
32
100
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
6.7
209
1428
P03
ICPC
Feeling depressed
2.1
6.7
74
366
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
6.7
104
584
FN1XT
NOMESCO Finland
Other coronary artery procedure through catheter
7.2
6.7
15
21
B03BA03
ATC
hydroxocobalamin; parenteral
2.1
6.7
74
367
B03XA02
ATC
darbepoetin alfa; parenteral
4.0
6.7
25
64
N05CF02
ATC
zolpidem; oral
1.6
6.7
186
1241
SPAT1240
SPAT
Therapeutic discussion
1.9
6.6
92
495
L60.0
ICD-10 Finland
Ingrowing nail
2.5
6.6
50
206
E26.0
ICD-10 Finland
Primary hyperaldosteronism
7.8
6.6
14
18
137
Kela drug reimbursment
Uraemia requiring dialysis
7.8
6.6
14
18
A10BJ05
ATC
dulaglutide; parenteral
5.9
6.6
17
29
B05DB
ATC
Hypertonic solutions
12.3
6.6
11
9
N03AX09
ATC
lamotrigine; oral
2.6
6.6
46
182
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
6.5
73
366
AP1
HP
Catheterization of the left side of the heart
3.7
6.5
26
71
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
6.5
85
451
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.1
6.4
33
109
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
6.4
285
2100
R04.0
ICD-10 Finland
Epistaxis
1.9
6.4
92
502
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
6.4
168
1106
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
4.9
6.4
19
39
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.0
6.3
76
390
J01EA01
ATC
trimethoprim; systemic
1.5
6.3
250
1801
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
8.2
6.3
13
16
4029A
ICD-9 Finland
Hypertensive heart disease, Unspecified[DECOMPENSATIO CORDIS NON INDICATA (WHO II)]
8.2
6.3
13
16
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
6.3
160
1041
S17
ICPC
Abrasion/scratch/blister
3.1
6.3
32
105
6488A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance
6.0
6.3
16
27
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.3
6.3
54
239
WZA90
NOMESCO Finland
Other doctors statement
1.5
6.3
244
1754
T78.4
ICD-10 Finland
Allergy, unspecified
2.7
6.3
41
157
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.3
308
2315
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.3
788
6896
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
+∞
6.3
6
*
E78.8
ICD-10 Finland
Other disorders of lipoprotein metabolism
+∞
6.3
6
*
2724X
ICD-9 Finland
Disorders of lipoid metabolism, Other and unspecified hyperlipidaemia[HYPERLIPOIDAEMIA ALIA]
+∞
6.3
6
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
6.2
89
486
N03.2
ICD-10 Finland
Chronic nephritic syndrome, diffuse membranous glomerulonephritis
26.8
6.2
8
*
M01AE02
ATC
naproxen; oral, rectal
1.3
6.2
651
5540
104
Kela drug reimbursment
Thyroid insufficiency
2.0
6.2
71
359
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
6.2
354
2733
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.6
6.2
86
1412
A10BX09
ATC
[U] dapagliflozin; oral
5.0
6.2
18
36
XF640
NOMESCO Finland
NA
2.6
6.2
42
166
S06.0
ICD-10 Finland
Concussion
1.7
6.2
117
701
SPAT1054
SPAT
Examination of peripheral nervous system
3.2
6.1
29
91
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
2.8
6.1
36
130
C09DA07
ATC
telmisartan and diuretics; oral
2.2
6.1
58
270
E78
ICD-10 Finland
Disorders of lipoprotein metabolism and other lipidaemias
2.5
6.1
44
179
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
6.1
78
410
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
6.1
692
5956
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.8
6.1
106
619
A10BH02
ATC
vildagliptin; oral
2.9
6.1
33
114
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.1
118
716
L03
ICPC
Low back symptom/complaint
1.5
6.1
249
1809
XCD20
NOMESCO Finland
Photoangiography of eye
3.4
6.1
27
81
N02AC04
ATC
dextropropoxyphene; oral
2.3
6.0
53
239
A10BD08
ATC
metformin and vildagliptin; systemic
5.2
6.0
17
33
FNC40
NOMESCO Finland
Aorto-coronary venous bypass with four distal anastomoses
5.2
6.0
17
33
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
5.2
6.0
17
33
I20.9
ICD-10 Finland
Angina pectoris, unspecified
4.2
6.0
21
51
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERLIPMIX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERLIPMIX | 1.44 [1.28, 1.62] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 748 out of 2730 females with E4_HYPERLIPMIX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERLIPMIX | 1.599 [1.45, 1.76] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 1357 out of 4799 males with E4_HYPERLIPMIX died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERLIPMIX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.169% | 0.275% |
| 5 | 0.803% | 1.708% |
| 10 | 2.097% | 4.536% |
| 15 | 4.065% | 8.75% |
| 20 | 7.427% | 14.817% |
Relationships between endpoints
↥Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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