Polycystic ovarian syndrome

E4_PCOS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E28.2
  • Hospital discharge: ICD-9 2564
  • Hospital discharge: ICD-8 25690
  • Cause of death: ICD-10 E28.2
  • Cause of death: ICD-9 2564
  • Cause of death: ICD-8 25690

2 out of 7 registries used, show all original rules.

2514

4. Check minimum number of events

None

2514

5. Include endpoints

None

2514

6. Filter based on genotype QC (FinnGen only)

2349

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
E28
Name in latin
Morbus polycysticus ovariorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13242 13242 -
Only index persons 13074 13074 -
Unadjusted period prevalence (%)
Whole population 0.38 0.38 -
Only index persons 0.48 0.48 -
Median age at first event (years)
Whole population - 27.37 -
Only index persons - 27.35 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2349 2349 -
Unadjusted period prevalence (%) 0.83 0.83 -
Median age at first event (years) 28.47 28.47 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2514
Matched controls
25140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
2222.6
307.7
2344
155
A10BA02
ATC
metformin; oral
9.5
307.7
1094
1889
G03DB01
ATC
dydrogesterone; oral
8.2
307.7
1255
2721
N97.0
ICD-10 Finland
Female infertility associated with anovulation
28.1
307.7
910
498
N91.1
ICD-10 Finland
Secondary amenorrhoea
9.0
306.3
414
540
L68.0
ICD-10 Finland
Hirsutism
20.6
288.5
224
119
L02BG04
ATC
letrozole; oral
5.8
257.2
549
1151
N97.9
ICD-10 Finland
Female infertility, unspecified
4.6
226.2
669
1833
E66.01
ICD-10 Finland
Obesity due to excess calories
4.2
188.4
626
1850
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
5.6
174.6
370
758
G03GA01
ATC
chorionic gonadotrophin; parenteral
4.6
152.1
412
1033
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
4.9
141.0
345
795
G03GB02
ATC
clomifene; oral
8.3
126.9
173
223
2564A
ICD-9 Finland
Ovarian dysfunction, Polycystic ovaries
+∞
124.0
118
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.7
121.6
1498
8974
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
11.4
113.4
120
110
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
112.7
690
2896
E66.8
ICD-10 Finland
Other obesity
4.1
108.6
336
921
C03DA01
ATC
spironolactone; oral
4.8
102.9
249
564
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
3.4
99.6
402
1316
T90
ICPC
Diabetes non-insulin dependent
3.4
85.4
336
1077
G03HB01
ATC
cyproterone and estrogen; oral
2.5
82.2
711
3471
TLW00
NOMESCO Finland
Insemination
4.3
82.1
226
565
E66.00
ICD-10 Finland
Metabolic syndrome
5.0
82.0
186
398
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.6
81.7
301
924
G03GA06
ATC
follitropin beta; parenteral
4.5
80.7
209
498
G03GA05
ATC
follitropin alfa; parenteral
3.3
76.5
313
1025
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
3.7
74.6
257
753
N91.3
ICD-10 Finland
Primary oligomenorrhoea
20.8
72.5
55
27
25690
ICD-8 Finland
Ovarian dysfunction, Syndroma Stein-Leventhal
+∞
70.1
67
*
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
7.3
68.8
103
147
103
Kela drug reimbursment
Diabetes, insulin-treated
2.9
68.6
380
1478
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
68.4
378
1468
Z31.2
ICD-10 Finland
In vitrofertilization
6.5
65.1
108
172
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
7.7
63.8
90
120
G03DA04
ATC
progesterone; systemic, rectal, vaginal
4.5
60.5
154
361
G03GA02
ATC
human menopausal gonadotrophin; parenteral
3.7
60.3
206
598
X05
ICPC
Menstruation absent/scanty
4.2
58.0
160
399
G47.3
ICD-10 Finland
Sleep apnoea
2.6
57.9
394
1693
E66.9
ICD-10 Finland
Obesity, unspecified
3.6
57.4
201
593
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
5.3
55.8
114
222
T82
ICPC
Obesity
3.3
54.3
215
686
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.4
54.1
435
2014
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.4
53.7
140
334
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.5
51.3
359
1558
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.4
49.9
130
310
G03DA02
ATC
medroxyprogesterone; systemic
3.3
48.5
192
612
N98.1
ICD-10 Finland
Hyperstimulation of ovaries
6.8
48.1
76
115
N97.4
ICD-10 Finland
Female infertility associated with male factors
3.5
46.9
168
502
LCA06
NOMESCO Finland
Biopsy of endometrium
2.3
45.7
397
1891
H01CC01
ATC
ganirelix; parenteral
2.9
45.7
236
876
TLW12
NOMESCO Finland
Insertion of frozen embryo
3.5
45.7
163
486
A10BJ06
ATC
semaglutide; parenteral
4.2
44.9
121
296
1413
FHL
Laparoscopy and other therapeutic procedure
6.7
42.6
68
104
E66
ICD-10 Finland
Obesity
2.8
42.0
231
886
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
41.9
417
2096
A10BK03
ATC
empagliflozin; oral
3.6
40.9
139
401
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.0
40.7
572
3265
G03DC02
ATC
norethisterone; oral
2.7
40.5
230
896
E22.1
ICD-10 Finland
Hyperprolactinaemia
53.2
39.6
47
9
LA2HE
NOMESCO Finland
Repeated measurement of ovarian cyst
4.6
38.7
92
204
Z31.1
ICD-10 Finland
Artificial insemination
5.8
38.4
71
126
Z32.1
ICD-10 Finland
Pregnancy confirmed
1.8
38.2
754
4788
G03GA04
ATC
urofollitropin; parenteral
8.5
37.8
49
59
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
36.2
564
3317
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.9
35.8
181
663
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
34.1
588
3563
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
33.2
163
587
8201
FHL
Ovarian preservation exploration and related procedures, eg resection, enucleation or ovariolysis
8.2
32.5
43
53
LBF00
NOMESCO Finland
Perfusion of Fallopian tube
7.3
31.4
46
64
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
30.5
972
6952
L02AE01
ATC
buserelin; implant, nasal, parenteral
4.4
29.3
73
168
B02AA02
ATC
tranexamic acid; systemic
1.8
28.8
487
2915
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
28.6
507
3079
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
27.9
285
1435
H03AA01
ATC
levothyroxine sodium; systemic
1.7
27.6
578
3679
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
3.7
27.6
89
248
JAH01
NOMESCO Finland
Laparoscopy
2.5
27.5
174
713
W15
ICPC
Infertility/subfertility female
3.8
27.2
84
227
XLA10, ,
NOMESCO Finland
2.8
27.2
136
495
SPAT1262
SPAT
Handing over of treatment supplies
2.1
26.5
284
1455
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
25.8
412
2415
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
25.3
478
2947
N02AX02
ATC
tramadol; systemic, rectal
1.6
25.2
737
5103
N06AX16
ATC
venlafaxine; oral
1.8
24.8
460
2819
E28.1
ICD-10 Finland
Ovarian dysfunction: Androgen excess
252.6
24.7
25
*
TLW20
NOMESCO Finland
Medical ovulation induction
7.5
24.6
35
47
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
24.5
317
1734
Z31.3
ICD-10 Finland
Other assisted fertilization methods
5.3
23.9
48
92
A10BH01
ATC
sitagliptin; oral
3.2
23.7
93
294
SPAT1310
SPAT
Counselling related to known health issue
1.6
23.6
877
6408
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
23.0
312
1733
A10BJ02
ATC
liraglutide; parenteral
3.7
22.9
72
197
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.0
22.9
257
1336
205
Kela drug reimbursment
Chronic hypertension
2.5
22.9
144
589
LA2JE
NOMESCO Finland
Follow-up of menstrual cycle with repeated measurement of ovarian cyst
4.9
22.7
50
104
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.0
22.7
253
1313
C07AB07
ATC
bisoprolol; oral
1.7
22.6
543
3564
SPAT1263
SPAT
Sampling
1.5
22.5
1167
9139
A10AC01
ATC
insulin (human); parenteral
2.3
22.1
183
846
E28.0
ICD-10 Finland
Ovarian dysfunction: Estrogen excess
+∞
21.9
21
*
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
2.1
21.8
211
1038
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.6
21.8
701
4936
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
21.8
494
3190
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
7.5
21.6
31
42
1410
FHL
Laparoscopy
4.3
21.6
55
129
A02BC02
ATC
pantoprazole; systemic
1.5
21.5
1347
10934
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
21.1
1084
8436
N05AH04
ATC
quetiapine; oral
1.6
20.9
538
3586
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
4.4
20.6
52
121
N97.8
ICD-10 Finland
Female infertility of other origin
2.5
20.5
137
576
J02AC01
ATC
fluconazole; systemic
1.5
20.4
1234
9899
WX704
NOMESCO Finland
Intubation
2.1
19.8
188
918
R51.80
ICD-10 Finland
Headache
1.6
19.8
538
3629
SPAT1301
SPAT
No procedures
1.5
19.7
747
5433
R4190
NOMESCO Finland
Nutritional therapy
2.7
19.6
105
396
B01AB05
ATC
enoxaparin; parenteral
1.6
19.6
523
3511
N91.0
ICD-10 Finland
Primary amenorrhoea
7.4
19.5
28
38
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.9
19.5
254
1390
R5140
NOMESCO Finland
Monitoring the use of the aid
2.4
19.4
138
597
L17
ICPC
Foot/toe symptom/complaint
1.6
19.1
621
4361
R03AC02
ATC
salbutamol; inhalant
1.5
19.1
1429
11893
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.7
18.7
361
2224
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
18.5
406
2588
A10BG03
ATC
pioglitazone; oral
6.9
18.3
28
41
C08CA01
ATC
amlodipine; oral
1.8
18.2
283
1636
M54.5
ICD-10 Finland
Low back pain
1.5
18.2
923
7105
N91
ICD-10 Finland
Absent, scanty and rare menstruation
5.4
18.1
35
65
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
4.1
18.0
49
121
OAB72
NOMESCO Finland
Weight control and weight loss guidance
4.1
18.0
49
121
6280A
ICD-9 Finland
Infertility, female, Associated with anovulation[STERILITAS ET INFERTILITAS ANOVULATORIA PRIM]
26.9
17.8
24
9
A10BD07
ATC
metformin and sitagliptin; systemic
4.7
17.8
41
89
N03AX12
ATC
[U] gabapentin; oral
1.8
17.7
297
1757
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
2.9
17.6
81
282
E66.0
ICD-10 Finland
Obesity due to excess calories
5.8
17.6
32
56
N06AX12
ATC
bupropion; oral
1.8
17.5
292
1724
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.5
17.5
660
4775
N06AB04
ATC
citalopram; systemic
1.6
17.2
466
3129
N02BE01
ATC
paracetamol; systemic, rectal
1.6
17.1
2104
19122
M79.7
ICD-10 Finland
Fibromyalgia
2.3
17.1
126
554
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.5
17.0
111
462
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
17.0
1385
11597
C09CA01
ATC
losartan; oral
1.9
16.9
224
1230
H01
ICPC
Ear pain/earache
1.6
16.8
412
2700
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.0
16.8
199
1054
A10BK01
ATC
dapagliflozin; oral
2.8
16.7
84
307
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
16.4
1909
17026
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
16.4
541
3794
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
16.4
175
893
N06AX21
ATC
duloxetine; oral
1.7
16.3
296
1789
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
16.2
607
4374
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
6.0
16.0
28
47
E28.3
ICD-10 Finland
Primary ovarian failure
21.1
16.0
23
11
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.8
16.0
239
1365
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
15.8
258
1512
SPAT1260
SPAT
Consultation of another employee
1.6
15.7
418
2789
C09CA06
ATC
candesartan; oral
1.6
15.6
390
2562
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
15.6
259
1527
A02BC03
ATC
lansoprazole; oral
1.6
15.5
423
2838
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
15.5
281
1698
TLW10
NOMESCO Finland
Transfer of fresh embryo
2.3
15.4
113
496
Z31.6
ICD-10 Finland
General counselling and advice on procreation
2.9
15.4
74
264
R02
ICPC
Shortness of breath/dyspnoea
1.8
15.3
266
1589
G03DB02
ATC
megestrol; oral
3.8
15.2
46
123
M79.6
ICD-10 Finland
Pain in limb
1.4
15.0
938
7437
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
14.9
892
7013
N97.1
ICD-10 Finland
Female infertility of tubal origin
3.2
14.8
58
184
W85
ICPC
Gestational diabetes
1.7
14.7
305
1912
SFA20
NOMESCO Finland
Two-surface restoration
1.4
14.6
1543
13351
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.7
14.6
301
1883
LAA97
NOMESCO Finland
Other laparoscopic puncture of ovary
80.6
14.6
16
*
SPAT1283
SPAT
Restricted health certificate
1.4
14.6
846
6611
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
14.5
1131
9294
6289A
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]
6.6
14.5
23
35
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
14.3
331
2132
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
14.3
396
2665
WVA20, ,
SPAT
2.9
14.2
65
226
N03AX16
ATC
[U] pregabalin
1.6
14.1
370
2455
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
14.1
112
509
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.9
14.1
173
927
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.5
14.1
442
3058
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
14.0
127
609
UJF32
NOMESCO Finland
Coloscopy
1.6
13.9
340
2220
SPAT1153
SPAT
Removal of sutures
1.5
13.8
500
3563
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
13.8
396
2683
J01DB01
ATC
cefalexin; oral
1.5
13.7
2056
18823
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
13.7
159
836
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.2
13.7
114
529
R42
ICD-10 Finland
Dizziness and giddiness
1.6
13.7
394
2673
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
140.7
13.5
14
*
H02AB09
ATC
hydrocortisone; systemic
3.4
13.4
47
139
ULC02
NOMESCO Finland
Hysteroscopy
2.1
13.4
130
641
R73.0
ICD-10 Finland
Abnormal glucose tolerance test
3.6
13.3
43
121
B03BA03
ATC
hydroxocobalamin; parenteral
2.7
13.2
71
270
X07
ICPC
Menstruation irregular/frequent
2.2
13.1
114
538
N06AB03
ATC
fluoxetine; oral
1.6
13.1
296
1895
L03
ICPC
Low back symptom/complaint
1.4
13.0
714
5503
H01CA02
ATC
nafarelin; nasal
2.0
12.9
133
670
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
12.9
416
2890
G03HA01
ATC
cyproterone; systemic
19.1
12.9
19
10
N06AB10
ATC
escitalopram; oral
1.4
12.9
686
5255
N83.1
ICD-10 Finland
Corpus luteum cyst
2.7
12.8
69
262
R06.0
ICD-10 Finland
Dyspnoea
1.5
12.8
441
3109
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
12.7
145
757
J01MA02
ATC
ciprofloxacin; systemic
1.4
12.7
630
4762
ACC51
NOMESCO Finland
Release of median nerve
2.0
12.6
148
781
C09AA02
ATC
enalapril; systemic
2.0
12.4
138
715
LAC21
NOMESCO Finland
Laparoscopic destruction of lesion of ovary
2.9
12.2
58
206
C10AA07
ATC
rosuvastatin; oral
1.6
12.2
285
1837
121
Kela drug reimbursment
Severe hypofunction of sexual glands
3.4
12.2
43
128
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.9
12.2
168
935
K02.1
ICD-10 Finland
Caries of dentine
1.4
12.1
1663
14773
L15
ICPC
Knee symptom/complaint
1.5
11.9
454
3261
C10AA05
ATC
atorvastatin; oral
1.6
11.9
266
1697
L68.9
ICD-10 Finland
Hypertrichosis, unspecified
14.7
11.8
19
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
11.8
596
4514
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
11.7
64
245
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
11.7
301
1985
N92.5
ICD-10 Finland
Other specified irregular menstruation
1.7
11.7
215
1302
SGA01
NOMESCO Finland
Emergency treatment
1.5
11.7
467
3386
P06
ICPC
Sleep disturbance
1.6
11.6
331
2234
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.4
11.6
77
324
M02AA07
ATC
piroxicam; topical
1.5
11.6
480
3501
WX290
NOMESCO Finland
Other blockage of nerve
1.3
11.6
1469
12844
P76
ICPC
Depressive disorder
1.6
11.6
265
1699
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.8
11.5
58
213
A10AE04
ATC
insulin glargine; parenteral
2.0
11.5
130
677
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.3
11.5
84
369
SPAT1240
SPAT
Therapeutic discussion
1.5
11.5
437
3136
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
11.5
11
*
K86
ICPC
Hypertension uncomplicated
2.3
11.5
85
376
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
11.4
1699
15203
M25.5
ICD-10 Finland
Pain in joint
1.4
11.4
738
5822
SGB10
NOMESCO Finland
Root filling of tooth with one root canal
1.7
11.4
242
1523
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.8
11.4
180
1045
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
11.3
1971
18085
G43.9
ICD-10 Finland
Migraine, unspecified
1.6
11.3
284
1864
D01
ICPC
Abdominal pain/cramps general
1.5
11.2
383
2688
N85.1
ICD-10 Finland
Endometrial adenomatous hyperplasia
4.6
11.2
26
57
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
11.1
804
6449
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
11.1
441
3191
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
11.1
381
2678
S18
ICPC
Laceration/cut
1.4
11.0
760
6050
P01AB01
ATC
metronidazole; oral, rectal
1.3
11.0
967
7988
R53
ICD-10 Finland
Malaise and fatigue
1.4
10.9
617
4753
C09AA05
ATC
ramipril; oral
1.9
10.9
146
805
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
3.7
10.9
33
89
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
2.0
10.8
119
614
A03
ICPC
Fever
1.4
10.8
599
4599
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
2.3
10.8
77
335
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.7
10.8
201
1222
T83
ICPC
Overweight
2.4
10.8
75
323
G02CB03
ATC
cabergoline; oral
4.0
10.8
30
76
C03CA01
ATC
furosemide; systemic
1.8
10.7
156
883
N03AE01
ATC
clonazepam; systemic
2.1
10.6
94
448
A02BC01
ATC
omeprazole; systemic
1.4
10.5
518
3893
N03AX09
ATC
lamotrigine; oral
1.7
10.5
178
1054
SPAT1097
SPAT
Recording of ECG
1.8
10.5
170
994
A10AB05
ATC
insulin aspart; parenteral
1.9
10.5
124
657
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
7.7
10.4
23
30
R96
ICPC
Asthma
1.7
10.4
197
1204
N84.0
ICD-10 Finland
Polyp of corpus uteri
1.9
10.3
140
775
C10AB05
ATC
fenofibrate; oral
5.2
10.3
21
41
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
10.3
1216
10449
A01
ICPC
Pain general/multiple sites
1.7
10.2
186
1123
N06AX11
ATC
mirtazapine; oral
1.4
10.2
715
5693
K04.0
ICD-10 Finland
Pulpitis
1.5
10.2
297
2013
QBJ30
NOMESCO Finland
Correction of abdominal apron
3.2
10.1
39
123
R05
ICPC
Cough
1.4
10.1
605
4696
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.4
10.1
501
3768
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
10.1
406
2939
M79.1
ICD-10 Finland
Myalgia
1.5
10.1
395
2845
S10
ICPC
Boil/carbuncle
1.9
10.1
128
694
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
1.5
10.1
297
2019
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
10.0
455
3370
JN3AD
NOMESCO Finland
Abdominal CT examination
1.7
10.0
167
985
SGA02
NOMESCO Finland
Opening and preparing the root canals
1.5
10.0
287
1940
H70
ICPC
Otitis externa
2.6
10.0
56
218
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.4
10.0
435
3198
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
2.3
9.9
72
316
SGC00
NOMESCO Finland
Medication, disinfection of root canals
1.5
9.9
284
1918
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.0
9.9
43
146
E23.05
ICD-10 Finland
Lack of TSH
16.8
9.9
15
9
C10AA01
ATC
simvastatin; oral
1.7
9.9
182
1104
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
9.8
202
1260
SPAT1216
SPAT
Assessment of functional ability
1.7
9.8
182
1105
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.3
9.8
70
305
XLD10
NOMESCO Finland
Gynaecological examination
2.8
9.8
48
174
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
9.8
456
3390
P03
ICPC
Feeling depressed
1.4
9.8
428
3146
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
9.8
347
2452
M01AH05
ATC
etoricoxib; oral
1.3
9.8
1240
10732
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
9.7
906
7511
R09
ICPC
Sinus symptom/complaint
1.5
9.7
303
2083
D07AC01
ATC
betamethasone; topical
1.3
9.7
709
5674
SFA30
NOMESCO Finland
Three-surface restoration
1.3
9.7
802
6540
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
9.6
869
7176
A10BX07
ATC
[U] liraglutide
5.0
9.6
20
40
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.5
9.5
284
1937
A10BH05
ATC
linagliptin; oral
3.7
9.4
29
79
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
9.4
170
1025
E21.0
ICD-10 Finland
Primary hyperparathyroidism
100.4
9.4
10
*
WX720
NOMESCO Finland
Own respiration
2.1
9.4
87
422
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
2.3
9.4
70
311
E28.8
ICD-10 Finland
Other ovarian dysfunction
30.1
9.4
12
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
9.4
9
*
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
0.6
9.4
213
3217
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.0
9.3
104
540
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.0
9.3
95
478
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
4.5
9.3
22
49
C07AB02
ATC
metoprolol; systemic
1.7
9.3
184
1137
M03BX02
ATC
tizanidine; oral
1.3
9.3
1393
12290
SPAT1307
SPAT
Psychosocial counselling and guidance
1.5
9.2
312
2181
L73.2
ICD-10 Finland
Hidradenitis suppurativa
2.6
9.2
52
203
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.0
9.2
102
529
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.1
9.2
90
447
Z31.4
ICD-10 Finland
Procreative investigation and testing
2.4
9.2
60
252
A10BB12
ATC
glimepiride; oral
3.9
9.1
26
67
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.7
9.1
153
904
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
9.1
174
1067
SPAT1229
SPAT
Assessment of need for aid
2.2
9.0
76
356
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.7
9.0
150
885
EBA00
NOMESCO Finland
Extraction of tooth
1.3
9.0
908
7593
J01FA10
ATC
azithromycin; systemic
1.3
9.0
1583
14237
J01FF01
ATC
clindamycin; systemic
1.4
8.9
507
3894
WX780
NOMESCO Finland
Remote monitoring CPAP
2.4
8.9
60
255
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.6
8.9
194
1228
N03AX11
ATC
topiramate; oral
2.0
8.9
93
472
N97
ICD-10 Finland
Female infertility
2.5
8.9
52
207
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
8.8
182
1137
N06AB06
ATC
sertraline; oral
1.5
8.8
341
2448
M01AE02
ATC
naproxen; oral, rectal
1.3
8.8
1448
12888
N06AB05
ATC
paroxetine; oral
1.8
8.8
136
785
TLW14
NOMESCO Finland
ICSI
2.5
8.7
51
203
C08CA13
ATC
lercanidipine; oral
2.0
8.7
93
476
SPAT1312
SPAT
General health counselling
1.3
8.7
906
7598
OAB72, ,
SPAT
2.6
8.7
50
198
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
8.7
430
3229
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
2.5
8.6
52
210
SPAT1254
SPAT
Administration of medicine
1.5
8.6
307
2168
G44.2
ICD-10 Finland
Tension-type headache
1.4
8.6
392
2899
C09CA03
ATC
valsartan; oral
2.3
8.6
65
291
SPAT1360
SPAT
Extensive global examination
1.8
8.6
123
694
A02BC05
ATC
esomeprazole; systemic
1.3
8.6
701
5685
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
8.2
8.6
18
22
H02AB06
ATC
prednisolone; systemic
1.3
8.5
886
7427
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.5
8.4
305
2160
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.7
8.4
151
909
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
8.4
509
3945
G93.2
ICD-10 Finland
Benign intracranial hypertension
4.3
8.4
21
49
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
8.4
114
633
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
8.4
430
3247
160
Kela drug reimbursment
exenatide
3.8
8.3
25
67
WX702
NOMESCO Finland
Supraglottic ventilation device
1.9
8.3
104
562
E30.1
ICD-10 Finland
Precocious puberty
+∞
8.3
8
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
8.3
8
*
EB1VA, ,
NOMESCO Finland
1.5
8.3
275
1913
SPAT1139
SPAT
Nutrition survey
2.2
8.3
70
328
N96
ICD-10 Finland
Habitual aborter
2.8
8.3
41
150
L08
ICPC
Shoulder symptom/complaint
1.4
8.3
348
2536
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.6
8.2
183
1166
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
2.0
8.2
86
438
OAB50, ,
SPAT
2.1
8.2
74
357
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
8.2
695
5663
C08CA05
ATC
nifedipine; systemic
2.0
8.1
82
412
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
1.9
8.1
107
589
J01AA02
ATC
doxycycline; systemic
1.3
8.1
1528
13769
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
1.8
8.1
116
656
N05BA01
ATC
diazepam; systemic, rectal
1.6
8.0
201
1319
R52.9
ICD-10 Finland
Pain, unspecified
1.6
8.0
193
1255
R03BA05
ATC
fluticasone; inhalant
1.4
7.9
420
3184
R03DC03
ATC
montelukast; oral
1.4
7.9
383
2860
F34.1
ICD-10 Finland
Dysthymia
1.8
7.9
110
616
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.5
7.9
252
1741
L84
ICPC
Back syndrome without radiat pain
1.8
7.9
109
609
D06
ICPC
Abdominal pain localized other
1.5
7.9
259
1800
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
1.6
7.9
186
1203
N03AG01
ATC
valproic acid; systemic, rectal
1.8
7.8
124
722
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
7.8
147
898
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.8
117
671
F43.1
ICD-10 Finland
Post-traumatic stress disorder
1.7
7.8
134
799
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
7.7
830
6963
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
45.1
7.7
9
*
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
1.6
7.7
156
972
J01FA06
ATC
roxithromycin; oral
1.3
7.7
762
6330
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
7.6
362
2693
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
7.6
231
1578
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
1.6
7.6
195
1284
LCA96
NOMESCO Finland
Other intrauterine operation
4.0
7.6
21
53
K04.08
ICD-10 Finland
Other specified pulpit
1.5
7.6
237
1631
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
2.3
7.6
52
224
K08.80
ICD-10 Finland
Toothache NOS
1.5
7.5
254
1774
O20.0
ICD-10 Finland
Threatened abortion
1.8
7.5
106
596
J45.1
ICD-10 Finland
Nonallergic asthma
1.7
7.5
128
761
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
3.0
7.5
32
108
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.6
7.5
161
1017
N05BA04
ATC
oxazepam; oral
1.3
7.5
563
4500
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.6
7.5
151
939
UDC00
NOMESCO Finland
Ear microscopy
1.7
7.5
136
823
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
7.4
210
1414
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
80.3
7.4
8
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.6
7.4
24
68
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.9
7.4
90
483
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.5
7.4
261
1840
C09BA02
ATC
enalapril and diuretics; systemic
2.6
7.4
40
154
G03FB06
ATC
medroxyprogesterone and estrogen; systemic
2.2
7.4
60
278
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
1.7
7.3
126
751
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.7
7.3
286
3894
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
7.3
217
1477
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
7.3
7
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
7.3
7
*
B81
ICPC
Anaemia vit B12/folate deficiency
2.5
7.3
42
167
H13
ICPC
Plugged feeling ear
1.5
7.2
240
1671
N92.2
ICD-10 Finland
Excessive menstruation at puberty
4.3
7.2
18
42
SPAT1050
SPAT
Extensive neurological examination
2.4
7.2
48
204
J20
ICD-10 Finland
Acute bronchitis
1.5
7.2
212
1440
R03BA01
ATC
beclometasone; inhalant
1.5
7.2
252
1774
A46
ICD-10 Finland
Erysipelas
1.7
7.2
128
771
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
7.2
510
4042
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
1.3
7.1
447
3476
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
7.1
641
5245
L68.2
ICD-10 Finland
Localized hypertrichosis
20.1
7.1
10
5
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.4
7.1
354
2654
K04.1
ICD-10 Finland
Necrosis of pulp
1.5
7.1
239
1668
L01
ICPC
Neck symptom/complaint
1.4
7.1
395
3016
SPAT1058
SPAT
PEF monitoring instruction
1.6
7.1
149
937
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
2.0
7.0
76
392
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.4
7.0
46
194
N02AA05
ATC
oxycodone; systemic
1.7
7.0
133
814
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
1.9
7.0
83
442
J01DA01
ATC
[U] cefalexin
1.3
7.0
1356
12154
TJK01
NOMESCO Finland
Laparoscopic cholangiography
3.4
7.0
24
71
R06.5
ICD-10 Finland
Mouth breathing
1.7
6.9
126
763
J01CA08
ATC
pivmecillinam; oral
1.2
6.9
1273
11337
A10BJ05
ATC
dulaglutide; parenteral
3.1
6.9
28
92
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
1.5
6.9
200
1356
N05CF02
ATC
zolpidem; oral
1.4
6.9
334
2495
SFA10
NOMESCO Finland
One-surface restoration
1.2
6.8
1434
12955
K10.3
ICD-10 Finland
Alveolitis of jaws
1.6
6.8
154
986
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
1.6
6.8
158
1018
N06AA09
ATC
amitriptyline; systemic
1.7
6.8
112
661
62611
ICD-8 Finland
Disorders of menstruation, Oligomenorrhoea
40.2
6.8
8
*
TPH04, ,
SPAT
5.7
6.8
18
32
E66.1
ICD-10 Finland
Drug-induced obesity
5.7
6.8
18
32
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
1.9
6.7
79
420
KH1AD
NOMESCO Finland
CT of urinary organs
2.2
6.7
53
243
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.3
6.7
524
4205
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
1.4
6.7
263
1892
SPAT1131
SPAT
Colonoscopy
2.4
6.7
42
174
C07AA05
ATC
propranolol; systemic
1.3
6.7
528
4243
R00.0
ICD-10 Finland
Tachycardia, unspecified
1.8
6.7
102
589
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.6
6.6
167
1096
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
2.7
6.6
35
133
SPAT1211
SPAT
Application of soft bandage
1.6
6.6
172
1137
HAMTE, ,
NOMESCO Finland
3.1
6.6
27
89
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.8
6.6
898
10317
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
3.5
6.6
22
64
H66.9
ICD-10 Finland
Otitis media, unspecified
1.5
6.6
221
1544
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.9
6.6
81
438
P73
ICPC
Affective psychosis
4.2
6.5
17
41
R20.2
ICD-10 Finland
Paraesthesia of skin
1.5
6.5
178
1190
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
2.0
6.5
71
368
N92.4
ICD-10 Finland
Excessive bleeding in the premenopausal period
2.0
6.5
71
368
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
6.5
134
839
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.5
6.5
206
1422
B01AB04
ATC
dalteparin; parenteral
1.8
6.5
89
498
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
3.1
6.5
26
85
SGA03
NOMESCO Finland
Opening and preparing the root canals, complicated
1.4
6.5
251
1802
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
6.4
207
1433
N06AX26
ATC
vortioxetine; oral
1.5
6.4
226
1592
E26.0
ICD-10 Finland
Primary hyperaldosteronism
70.0
6.4
7
*
E34.35
ICD-10 Finland
Abnormal growth retardation
70.0
6.4
7
*
F32.1
ICD-10 Finland
Moderate depressive episode
1.5
6.4
225
1584
R60.0
ICD-10 Finland
Localized oedema
1.6
6.4
145
929
N02BF01
ATC
gabapentin; oral
1.6
6.4
135
850
XX_20
NOMESCO Finland
Bioimpedance measurement
7.4
6.4
14
19
B01AB10
ATC
tinzaparin; parenteral
1.6
6.4
148
953
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
2.0
6.4
66
336
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
2.6
6.4
35
136
G04CA02
ATC
tamsulosin; oral
2.4
6.4
41
172
M70.6
ICD-10 Finland
Trochanteric bursitis
1.5
6.4
177
1189
N05AX08
ATC
risperidone; systemic
1.6
6.4
128
797
WX002
NOMESCO Finland
Sedation and analgesia
1.4
6.4
250
1799
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
6.6
6.3
15
23
R2110
NOMESCO Finland
Giving the first information
1.5
6.3
181
1223
R11
ICD-10 Finland
Nausea and vomiting
1.5
6.3
218
1530
W84
ICPC
Pregnancy high risk
1.5
6.3
227
1606
R39.1
ICD-10 Finland
Other difficulties with micturition
2.8
6.3
30
108
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.6
6.3
20
56
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.4
6.3
300
2232
P01
ICPC
Feeling anxious/nervous/tense
1.3
6.3
582
4770
O61.0
ICD-10 Finland
Failed medical induction of labour
2.1
6.3
58
283
N71.1
ICD-10 Finland
Chronic inflammatory disease of uterus
5.5
6.3
17
31
L29.9
ICD-10 Finland
Pruritus, unspecified
2.0
6.3
65
331
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
18.1
6.3
9
5
M54.6
ICD-10 Finland
Pain in thoracic spine
1.5
6.3
171
1144
6261B
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Scanty or infrequent menstruation[OLIGOMENORRHOEA]
+∞
6.3
6
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
6.3
6
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
6.3
6
*
A10AE05
ATC
insulin detemir; parenteral
1.8
6.2
83
460
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.2
1289
11575
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.7
6.2
104
617
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
6.2
78
425
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.4
6.2
286
2118
AA1AD
NOMESCO Finland
CT of head and brain
1.4
6.1
273
2008
R01AD09
ATC
mometasone; nasal
1.2
6.1
1168
10390
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.3
6.1
540
4398
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
2.4
6.1
39
163
SPAT1388
SPAT
Extensive health check-up based on individual need
2.8
6.1
28
99
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
1.9
6.1
78
427
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
2.0
6.1
65
335
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
6.1
272
2003
T87
ICPC
Hypoglycaemia
8.6
6.1
12
14
D11
ICPC
Diarrhoea
1.3
6.0
369
2857
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.8
6.0
81
451
C10AC01
ATC
colestyramine; oral
2.1
6.0
52
248

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
698
1102
8.38
307.65
1.4
1.2
9.80
8.79
u/l
1.71
599
919
587
467
16.09
307.65
1.5
1.3
1.62
1.56
nmol/l
0.18
537
406
381
256
17.36
307.65
1.2
1.1
7.04
6.36
umol/l
1.67
360
238
709
2096
4.32
215.99
1.7
1.3
289.46
296.69
mu/l
0.26
658
1841
169
92
19.62
214.60
1.4
1.2
22.84
15.70
pmol/l
5.84
159
80
653
2275
3.53
151.30
1.4
1.3
9.09
20.08
iu/l
36.18
566
1956
462
1287
4.17
148.26
1.2
1.3
8.88
3.16
ug/l
14.33
453
1242
123
111
11.60
117.50
1.3
1.1
—
—
—
0
0
292
686
4.68
115.77
1.5
1.3
7.36
17.87
u/l
16.61
263
584
285
698
4.48
106.97
1.7
1.4
—
—
—
0
0
306
834
4.04
99.38
1.9
1.4
0.55
0.59
nmol/l
0.12
271
711
81
54
15.47
92.45
1.1
1.0
—
—
—
0
0
1979
15343
2.36
67.53
5.0
3.4
37.51
36.19
mmol/mol
9.64
1911
14544
203
546
3.96
66.48
1.4
1.4
29.34
31.49
nmol/l
0.44
189
497
2165
17993
2.46
54.28
5.4
4.2
14.23
14.16
pmol/l
0.93
2061
16829
401
1794
2.47
53.80
2.2
1.6
359.03
393.32
nmol/l
3.08
374
1633
2329
20197
3.08
50.83
6.3
4.8
2.78
1.79
mu/l
0.42
2259
19287
510
2602
2.20
50.12
3.2
3.5
506.23
436.89
mg/l
0.11
353
1750
1384
9960
1.87
50.00
4.1
3.5
6.27
6.02
mmol/l
4.36
1203
8574
520
2693
2.17
49.12
3.7
4.1
8.07
15.24
mg/mmol
3.38
352
1816
2141
17975
2.29
47.84
4.0
2.8
5.66
5.43
mmol/l
15.36
2037
16892
803
5156
1.82
39.44
2.5
2.3
54.20
55.28
u/l
0.10
752
4757
649
3922
1.88
38.59
3.1
3.2
8.60
7.89
mmol/l
2.37
562
3523
903
6041
1.77
38.39
3.9
3.7
36.65
37.13
g/l
2.02
848
5623
1125
8106
1.70
35.98
4.2
4.3
9.19
9.26
umol/l
0.11
1049
7536
2195
19245
2.11
34.04
10.3
7.4
3.88
3.87
mmol/l
2.27
2126
18523
2190
19211
2.09
33.50
10.2
7.3
139.36
139.35
mmol/l
0.04
2127
18555
1616
13062
1.66
31.32
5.9
5.6
71.44
68.77
u/l
2.84
1526
12294
64
127
5.14
30.65
1.3
1.2
—
—
—
0
0
54
95
5.79
29.46
1.8
1.3
0.96
1.37
nmol/l
0.71
44
69
70
156
4.59
29.25
1.4
1.2
338.91
406.84
mu/l
0.76
70
145
777
5290
1.68
29.23
5.8
4.8
1.02
1.04
inr
0.87
243
1897
71
163
4.45
28.59
1.5
1.2
70.85
72.76
%
0.41
71
152
628
4075
1.72
28.06
2.4
2.2
—
—
—
0
0
2121
18706
1.86
27.51
3.8
3.0
2.86
2.81
mmol/l
2.09
2036
17835
836
5903
1.62
26.74
2.0
1.6
96.05
98.77
pmol/l
1.03
472
3355
593
3849
1.71
26.22
2.8
2.2
6743.57
7297.36
u/l
0.18
264
1620
457
2764
1.80
25.87
1.5
1.5
—
—
—
0
0
1066
8049
1.56
25.25
2.6
2.1
68.64
71.68
nmol/l
3.83
1011
7565
2091
18504
1.77
24.92
3.6
2.8
1.38
1.54
mmol/l
63.21
2020
17717
715
4934
1.63
24.72
2.3
2.0
2.59
2.57
mg/l
0.12
642
4242
2098
18603
1.77
24.58
3.7
2.8
4.67
4.70
mmol/l
1.15
2027
17841
506
3196
1.73
24.51
1.5
1.4
19.91
20.83
nmol/l
0.81
460
2865
903
6603
1.57
24.40
5.0
4.3
1.22
1.21
mmol/l
0.91
763
5587
659
4478
1.64
24.15
1.6
1.6
—
—
—
0
0
877
6412
1.56
23.50
3.0
2.7
27.95
26.58
u/l
0.56
833
6113
40
66
6.14
23.30
1.9
1.6
124.80
127.70
nmol/l
0.15
40
66
2006
17654
1.67
23.12
3.3
2.6
1.37
1.11
mmol/l
41.10
1927
16885
487
3091
1.71
23.03
1.8
1.5
10698064.99
38504470.40
pmol/l
1.11
430
2714
544
3562
1.67
22.88
2.0
2.0
855.59
3091.80
umol/l
2.58
499
3245
65
166
3.99
22.81
2.1
1.2
—
—
—
0
0
886
6562
1.54
22.07
1.4
1.3
1.48
1.62
u/ml
0.10
248
1905
364
2159
1.80
21.71
1.9
1.6
1225.90
1153.86
nmol/l
0.90
306
1656
247
1293
2.01
21.58
3.8
4.3
1.08
1.05
mmol/l
0.79
237
1211
1578
13320
1.50
20.11
3.3
2.9
55.10
51.09
ug/l
1.45
1515
12654
563
3858
1.59
19.31
1.6
1.5
1.55
1.25
mmol/l
9.62
502
3409
790
5840
1.51
19.25
4.3
3.8
1.22
1.22
mmol/l
0.84
726
5348
838
6286
1.50
18.97
2.6
2.1
—
—
—
0
0
631
4470
1.55
18.62
2.5
2.2
18.98
18.46
ng/l
0.04
216
1387
415
2667
1.67
18.36
1.3
1.2
135.38
157.07
iu/ml
0.47
156
1043
1753
15246
1.49
18.27
4.6
3.8
561.52
1444.16
e6/l
1.11
25
149
1765
15468
1.47
16.88
4.5
3.8
—
—
—
0
0
674
4939
1.50
16.68
2.3
2.6
2.33
2.34
mmol/l
0.75
612
4491
2278
21184
1.80
16.48
10.9
8.2
64.51
64.27
umol/l
0.19
2278
21176
1322
11033
1.42
16.14
2.6
2.4
—
—
—
0
0
309
1901
1.71
15.98
2.5
2.8
0.83
0.83
mmol/l
0.35
294
1789
1278
10627
1.41
15.79
2.7
2.4
—
—
—
0
0
479
3307
1.55
15.52
2.5
2.3
—
—
—
0
0
326
2064
1.67
15.11
1.5
1.4
—
—
—
0
0
350
2260
1.64
15.01
1.2
1.2
—
—
—
0
0
1646
14393
1.42
14.70
3.8
3.4
9.72
8.46
mm/h
6.08
1544
13509
336
2159
1.64
14.68
2.0
2.0
2.63
2.53
g/l
2.60
313
1995
154
781
2.04
14.65
1.2
1.3
—
—
—
0
0
626
4627
1.47
14.52
2.0
1.7
0.67
0.83
mg/l
2.62
458
3313
273
1668
1.71
14.43
3.5
2.6
29.55
33.57
%
8.87
225
1305
2303
21618
1.78
14.30
8.6
7.1
27.49
22.63
u/l
19.42
2244
20949
125
592
2.17
14.23
2.7
2.6
5.08
5.06
kpa
0.14
114
569
369
2457
1.59
13.89
2.1
2.0
14.05
14.92
umol/l
1.43
345
2291
169
903
1.93
13.86
1.1
1.1
1.71
4.45
u/ml
1.53
20
156
123
588
2.15
13.69
2.8
2.6
7.38
7.42
ph
—
10
82
278
1740
1.67
13.41
3.3
3.4
4.64
4.60
pmol/l
0.25
249
1572
34
80
4.29
13.37
1.8
1.2
93.91
71.78
nmol/24h
0.90
34
80
87
365
2.43
13.17
2.9
2.8
24.54
24.30
mmol/l
0.42
79
345
327
2159
1.59
12.70
1.7
1.5
—
—
—
0
0
64
238
2.73
12.40
2.3
2.8
1.10
0.90
nmol/l
0.88
49
203
293
1903
1.61
12.17
2.1
2.1
22.05
24.09
%
1.79
231
1646
2266
21328
1.63
11.99
11.2
8.7
16.98
18.28
mg/l
1.41
1898
16250
183
1059
1.79
11.68
2.2
2.2
0.24
0.23
g/l
0.62
170
991
77
332
2.36
11.02
1.1
1.1
11.48
3718.14
iu/ml
0.76
24
106
276
1810
1.59
10.98
2.3
2.4
371.52
416.62
ng/l
0.14
214
1396
513
3831
1.43
10.86
3.1
2.8
7.39
7.40
ph
2.06
105
726
1656
14829
1.34
10.64
3.2
2.5
34.08
27.84
u/l
6.69
1589
14232
1293
11182
1.32
10.56
3.3
3.1
0.00
0.00
estimate
1.30
268
2405
85
390
2.22
10.54
3.0
2.8
—
—
—
0
0
691
5454
1.37
10.49
1.4
1.4
1.96
2.01
g/l
0.60
425
3510
1207
10350
1.32
10.42
5.0
5.5
0.19
0.18
e9/l
1.49
1106
9352
79
356
2.26
10.24
5.8
4.1
1.23
1.13
mmol/l
0.87
70
309
273
1816
1.56
10.20
2.4
2.1
5.35
5.17
umol/l
0.11
226
1480
1163
9949
1.31
10.09
4.8
5.3
0.04
0.04
e9/l
1.02
1038
8854
1160
9931
1.31
9.96
4.8
5.3
0.53
0.51
e9/l
2.91
1040
8860
1280
11118
1.31
9.84
3.3
3.0
0.00
0.00
estimate
0.99
273
2481
2379
22827
1.79
9.84
12.1
8.2
—
—
—
0
0
307
2115
1.51
9.77
1.1
1.1
—
—
—
0
0
1279
11116
1.31
9.75
4.4
4.2
0.00
0.00
estimate
0.42
276
2450
607
4741
1.37
9.73
3.3
3.1
1.02
1.02
kg/l
0.14
109
737
1096
9347
1.31
9.54
5.2
5.6
—
—
—
0
0
1096
9362
1.30
9.37
5.0
5.2
2.58
2.69
%
1.10
1030
8791
430
3192
1.42
9.29
1.5
1.4
400.00
557.41
titre
1.41
70
634
1099
9424
1.30
9.01
5.4
5.5
7.26
7.64
%
4.96
1033
8879
1291
11313
1.29
8.91
6.4
7.4
4.24
3.98
e9/l
4.53
1154
10019
225
1479
1.57
8.85
1.7
2.3
20.92
33.12
u/ml
3.10
216
1430
99
517
1.95
8.77
6.8
5.9
23.77
23.81
mmol/l
0.04
93
489
1204
10473
1.29
8.74
4.7
5.2
2.18
2.01
e9/l
8.88
1100
9592
518
4039
1.36
8.23
1.4
1.3
31.30
21.03
iu/ml
0.89
147
1223
926
7857
1.28
7.94
2.2
1.9
—
—
—
0
0
1133
9861
1.27
7.89
4.8
5.0
56.22
56.50
%
0.42
1062
9332
478
3704
1.36
7.88
2.2
1.9
236.98
124.25
u/l
0.41
463
3508
298
2137
1.45
7.72
3.0
2.4
249.64
255.73
ng/l
0.01
116
841
1036
8945
1.27
7.62
5.1
5.3
0.62
0.65
%
1.14
962
8349
191
1256
1.56
7.51
3.5
2.5
—
—
—
0
0
1141
9980
1.26
7.48
5.0
5.2
30.54
30.09
%
0.87
1072
9444
121
709
1.74
7.48
3.2
2.7
100.91
61.80
ng/l
0.74
105
637
416
3188
1.37
7.32
3.4
3.2
—
—
—
0
0
207
1396
1.53
7.27
1.2
1.2
—
—
—
0
0
2071
19527
1.34
7.21
12.8
10.4
14.43
14.37
%
0.07
2044
19183
294
2133
1.43
7.14
1.9
1.7
—
—
—
0
0
1059
9301
1.24
6.34
1.9
1.8
—
—
—
0
0
85
474
1.82
6.26
1.2
1.3
67.27
97.83
titre
1.34
11
46
93
535
1.77
6.18
2.5
2.6
80.23
77.22
ng/l
0.06
82
462
2473
24260
2.19
6.07
17.4
13.2
88.74
89.54
fl
17.42
2459
24031
88
502
1.78
6.02
5.8
4.3
—
—
—
0
0
2473
24264
2.18
6.00
17.5
13.2
4.56
4.45
e12/l
34.62
2434
23781
15
25
6.03
5.99
1.1
1.1
15.01
11.57
pmol/l
0.57
15
25
1021
8970
1.23
5.99
2.9
2.8
5.93
6.04
ph
0.62
105
941
2474
24279
2.19
5.97
17.6
13.3
133.95
132.31
g/l
12.27
2459
24049
2473
24266
2.17
5.96
17.5
13.3
7.30
6.91
e9/l
12.88
2435
23752
209
1473
1.46
5.94
2.2
1.9
4.40
4.68
e9/l
0.38
176
1295
2472
24262
2.13
5.80
17.4
13.2
29.56
29.86
pg
14.77
2458
24031
47
219
2.17
5.76
1.1
1.1
1.04
1.04
ratio
0.10
14
85
127
811
1.60
5.72
5.2
6.9
96.56
96.69
%
0.10
121
787
2467
24201
2.04
5.70
17.3
13.2
40.14
39.50
%
10.61
2338
23200
175
1209
1.48
5.52
2.2
2.3
4.33
5.00
umol/l
0.85
122
906
150
1004
1.53
5.51
1.4
1.3
—
—
—
0
0
150
1009
1.52
5.39
1.4
1.3
2.20
1.20
u/ml
—
10
77
2468
24234
2.01
5.36
17.6
13.3
278.22
269.21
e9/l
10.95
2433
23764
184
1295
1.45
5.29
1.2
1.2
—
—
—
0
0
473
3854
1.28
5.28
1.4
1.3
7.75
9.10
u/ml
0.23
194
1639
48
234
2.07
5.27
1.8
1.7
—
—
—
0
0
152
1033
1.50
5.21
2.5
2.2
1.22
1.23
mmol/l
0.56
136
864
21
71
2.97
4.98
3.0
3.0
—
—
—
0
0
697
5983
1.23
4.89
3.6
3.2
0.00
0.00
estimate
1.94
272
2415
290
2244
1.33
4.74
1.9
2.1
2.40
2.39
mmol/l
0.72
248
1929
445
3649
1.27
4.69
2.3
2.4
93.10
90.41
ug/g
0.07
332
2819
141
968
1.48
4.63
5.1
6.4
0.72
0.33
mmol/l
0.71
97
692
206
1520
1.39
4.58
1.2
1.2
—
—
—
0
0
119
793
1.53
4.51
1.9
2.0
19.71
20.70
s
2.42
84
642
44
224
1.98
4.36
2.6
2.7
39.88
125.66
ug/min
1.36
30
155
768
6726
1.20
4.31
2.1
1.8
—
—
—
0
0
121
822
1.50
4.21
1.0
1.1
—
—
—
0
0
139
977
1.45
4.08
5.2
6.4
4.91
4.94
kpa
0.11
133
938
139
977
1.45
4.08
5.2
6.4
12.86
14.28
kpa
2.65
132
937
471
3948
1.24
4.06
1.4
1.4
—
—
—
0
0
11
22
5.02
4.00
1.2
1.3
—
—
—
0
0
424
3522
1.25
3.97
2.4
2.1
10.86
10.36
e6/l
0.20
381
3091
764
6755
1.19
3.77
3.1
3.0
57.06
65.66
e6/l
0.27
486
4111
226
1748
1.32
3.74
1.3
1.3
—
—
—
0
0
93
614
1.53
3.74
2.2
2.1
—
—
—
0
0
250
1961
1.31
3.74
1.5
1.4
—
—
—
0
0
48
268
1.81
3.66
2.2
2.0
—
—
—
0
0
13
35
3.73
3.59
1.2
1.1
—
—
—
0
0
577
4996
1.20
3.57
2.0
1.7
—
—
—
0
0
391
3257
1.24
3.56
2.5
2.2
540.53
537.87
mosm/kgh2o
0.08
342
2767
920
8295
1.17
3.55
1.9
1.9
—
—
—
0
0
13
36
3.62
3.49
1.2
1.1
—
—
—
0
0
71
449
1.60
3.46
6.9
7.9
—
—
—
0
0
756
6724
1.18
3.42
3.0
2.6
—
—
—
0
0
25
113
2.22
3.41
2.4
1.5
292.55
285.62
mosm/kgh2o
1.75
20
93
183
1398
1.33
3.32
2.3
2.3
10.42
10.56
g/l
0.21
170
1292
107
748
1.45
3.30
1.8
2.2
4.14
4.06
iu/l
0.04
37
323
23
102
2.27
3.29
1.1
1.1
—
—
—
0
0
1042
9545
1.16
3.17
1.8
1.9
—
—
—
0
0
46
267
1.74
3.12
2.1
2.1
1.75
1.86
mmol/l
0.15
24
129
32
166
1.94
3.09
1.6
1.3
493.07
459.63
pmol/l
0.14
27
146
560
4907
1.18
2.99
3.1
3.0
—
—
—
0
0
140
1045
1.36
2.99
1.6
1.7
1.25
1.42
g/l
1.55
131
968
196
1541
1.29
2.92
2.1
2.7
—
—
—
0
0
574
5052
1.18
2.90
2.9
2.5
22.92
98.48
e6/l
1.89
438
3678
28
142
1.98
2.90
1.0
1.1
—
—
—
0
0
1201
11162
1.15
2.90
2.2
2.1
—
—
—
0
0
148
1121
1.34
2.88
3.1
2.3
1.84
1.59
%
2.66
131
991
95
668
1.44
2.88
1.4
1.3
43.62
29.29
u/ml
—
9
48
534
4678
1.18
2.85
2.7
2.4
—
—
—
0
0
114
832
1.39
2.81
3.5
3.2
1.22
1.59
mmol/l
0.66
91
665
127
949
1.36
2.72
1.7
1.6
—
—
—
0
0
10
29
3.46
2.69
1.7
2.3
—
—
—
0
0
74
503
1.49
2.68
1.1
1.1
3.42
2.80
u/ml
0.21
35
295
8
19
4.22
2.67
3.4
1.9
—
—
—
0
0
52
327
1.60
2.66
1.1
1.1
—
—
—
0
0
85
596
1.44
2.64
1.5
1.3
1.79
13.10
u/ml
—
10
103
83
588
1.43
2.46
1.5
1.3
2.05
3.76
u/ml
—
6
64
19
89
2.14
2.44
5.2
5.9
10.76
10.66
mg/l
0.03
19
82
82
581
1.43
2.43
1.9
1.6
6.91
6.58
mmol/l
0.63
77
533
48
304
1.59
2.42
2.3
2.1
150.23
292.18
ug/l
0.53
35
259
54
352
1.55
2.41
1.1
1.1
—
—
—
0
0
22
110
2.01
2.40
3.3
3.3
—
—
—
0
0
208
1694
1.25
2.37
1.9
2.1
—
—
—
0
0
5
8
6.26
2.37
1.2
1.1
615.48
411.71
nmol/l
—
5
8
942
8701
1.13
2.36
1.7
1.7
—
—
—
0
0
44
275
1.61
2.35
2.4
1.7
1.32
1.78
ug/l
0.29
39
243
17
78
2.19
2.31
1.1
1.4
154.24
142.20
mmol/24h
0.33
17
78
97
718
1.37
2.25
2.3
2.1
81.23
71.03
e9/l
1.86
79
513
81
584
1.40
2.21
1.2
1.2
—
—
—
0
0
515
4587
1.15
2.20
2.7
2.5
0.25
0.27
e6/l
0.06
394
3331
124
959
1.31
2.16
1.5
1.6
—
—
—
0
0
7
19
3.69
2.15
1.3
1.4
—
—
—
0
0
50
330
1.53
2.14
4.4
4.2
—
—
—
0
0
44
282
1.57
2.14
1.1
1.1
32.89
33.18
mg/l
0.03
38
229
65
453
1.45
2.14
1.1
1.4
—
—
—
0
0
68
478
1.43
2.14
1.1
1.4
162.45
8548.24
e6/l
0.58
58
396
164
1317
1.26
2.14
1.0
1.1
—
—
—
0
0
68
479
1.43
2.12
1.1
1.4
2.57
21.48
e6/l
3.02
53
375
20
102
1.97
2.10
2.1
3.2
—
—
—
0
0
159
1283
1.26
2.00
3.6
4.1
0.00
0.41
%
0.64
43
233
19
97
1.97
2.00
3.1
3.1
—
—
—
0
0
7
21
3.34
1.96
1.1
1.0
—
—
—
0
0
506
4538
1.14
1.96
4.1
5.7
—
—
—
0
0
48
322
1.50
1.94
1.3
1.4
—
—
—
0
0
36
226
1.60
1.93
1.2
1.4
—
—
—
0
0
22
120
1.84
1.92
1.0
1.1
—
—
—
0
0
169
1381
1.24
1.92
3.5
4.0
0.72
0.88
%
0.38
54
326
26
151
1.73
1.87
1.0
1.1
—
—
—
0
0
8
28
2.86
1.86
1.1
1.6
—
—
—
0
0
44
296
1.50
1.77
2.9
2.0
133.97
131.64
g/l
0.42
38
225
77
574
1.35
1.77
1.1
1.2
243.40
244.42
u/ml
0.01
45
381
188
1570
1.21
1.75
2.7
2.2
26.75
32.69
u/l
3.05
153
1309
446
3997
1.14
1.75
3.6
2.9
99.48
98.37
%
0.49
432
3854
157
1289
1.23
1.73
3.5
3.7
0.55
0.64
%
0.15
49
290
255
2193
1.18
1.73
1.9
2.0
—
—
—
0
0
71
527
1.36
1.69
2.5
2.8
0.43
0.32
g/l
0.44
32
199
55
391
1.42
1.69
1.5
1.3
354.60
337.32
ug/g
0.17
26
176
254
2189
1.18
1.69
1.9
1.9
—
—
—
0
0
251
2163
1.18
1.67
1.9
2.0
—
—
—
0
0
25
149
1.68
1.66
1.2
1.1
—
—
—
0
0
252
2174
1.18
1.66
1.9
2.0
—
—
—
0
0
36
236
1.53
1.65
1.3
1.6
—
—
—
0
0
145
1188
1.23
1.64
2.9
3.1
—
—
—
0
0
23
135
1.71
1.62
1.3
1.1
—
—
—
0
0
257
2228
1.17
1.60
3.6
3.1
—
—
—
0
0
212
1809
1.19
1.59
1.3
1.3
98.73
198.50
u/ml
4.02
193
1681
18
99
1.82
1.57
1.2
1.5
—
—
—
0
0
29
184
1.58
1.54
1.1
1.1
1598.17
1476.63
miu/ml
0.22
29
184
33
216
1.53
1.54
1.2
1.0
—
—
—
0
0
23
138
1.67
1.51
1.0
1.1
—
—
—
0
0
31
202
1.54
1.48
2.6
2.4
—
—
—
0
0
6
22
2.73
1.43
1.0
1.8
—
—
—
0
0
37
254
1.46
1.40
3.9
4.1
31.13
84.22
u/ml
1.21
15
84
39
271
1.45
1.39
1.3
1.3
—
—
—
0
0
7
29
2.42
1.39
1.4
1.4
—
—
—
0
0
230
2002
1.16
1.39
2.0
2.1
—
—
—
0
0
114
930
1.24
1.38
2.4
2.6
—
—
—
0
0
15
261
0.57
1.36
1.0
1.0
0.09
0.41
u/ml
—
5
63
68
522
1.31
1.35
1.2
1.3
101.82
105.06
u/ml
0.11
12
107
27
175
1.55
1.34
1.3
1.2
—
—
—
0
0
24
152
1.58
1.31
1.0
1.0
5.14
16.10
u/ml
3.13
12
100
165
1405
1.19
1.31
3.1
2.5
—
—
—
0
0
15
83
1.81
1.31
2.0
2.4
14.09
14.28
umol/l
0.03
15
83
36
250
1.45
1.31
1.5
1.3
—
—
—
0
0
58
438
1.33
1.30
1.2
1.3
2.55
4.08
u/ml
1.27
22
187
62
473
1.32
1.29
1.1
1.1
—
—
—
0
0
5
18
2.78
1.28
1.8
1.1
15.69
16.90
umol/l
—
5
18
10
48
2.09
1.27
1.0
1.1
—
—
—
0
0
8
35
2.29
1.26
1.4
2.0
—
—
—
0
0
45
609
0.73
1.26
1.0
1.1
—
—
—
0
0
17
279
0.61
1.25
4.0
3.7
51.12
26.60
u/ml
0.28
17
271
70
547
1.29
1.24
1.4
1.3
34.94
37.74
u/ml
—
5
51
33
229
1.45
1.22
2.3
1.7
17.07
17.01
%
0.04
15
103
16
263
0.61
1.20
1.0
1.1
0.30
2.49
u/ml
—
7
90
17
275
0.62
1.19
1.0
1.0
0.26
3.03
u/ml
—
6
71
6
26
2.31
1.18
1.3
1.1
—
—
—
0
0
63
489
1.30
1.18
2.7
2.2
1.34
1.16
g/l
0.89
57
427
41
298
1.38
1.18
1.3
1.3
—
—
—
0
0
8
38
2.11
1.18
1.9
2.3
—
—
—
0
0
32
223
1.44
1.16
5.9
5.7
310.33
378.40
umol/l
2.55
27
186
17
273
0.62
1.16
1.2
1.9
—
29.15
—
0
20
8
39
2.05
1.15
1.0
1.1
—
—
—
0
0
46
609
0.75
1.14
1.0
1.1
—
—
—
0
0
60
766
0.78
1.14
1.6
1.7
—
—
—
0
0
155
1332
1.17
1.14
3.7
4.1
0.03
0.12
%
1.80
39
278
62
484
1.29
1.13
1.6
1.7
—
—
—
0
0
89
726
1.23
1.13
1.2
1.1
—
—
—
0
0
8
40
2.00
1.12
1.1
1.3
—
—
—
0
0
70
558
1.26
1.09
1.3
1.3
—
—
—
0
0
95
784
1.22
1.09
4.5
7.1
—
—
—
0
0
12
66
1.82
1.09
1.3
1.2
—
—
—
0
0
8
41
1.95
1.08
1.0
1.1
—
—
—
0
0
65
515
1.27
1.07
1.4
1.2
—
—
—
0
0
26
373
0.69
1.06
1.5
1.5
—
—
—
0
0
37
272
1.37
1.03
1.1
1.1
—
—
—
0
0
121
1030
1.18
1.01
1.5
1.7
—
—
—
0
0
5
23
2.18
0.98
1.2
1.0
36.48
37.70
s
—
5
16
5
23
2.18
0.98
1.6
3.4
—
—
—
0
0
7
37
1.89
0.94
2.0
1.9
30.63
25.59
ug/l
—
7
37
15
93
1.62
0.93
1.3
1.5
—
—
—
0
0
17
109
1.56
0.93
2.1
1.7
3.45
54.48
nmol/l
0.48
17
102
6
28
2.15
0.91
1.2
1.2
—
—
—
0
0
18
118
1.53
0.90
7.0
7.3
—
—
—
0
0
10
56
1.79
0.87
1.0
1.1
—
—
—
0
0
84
705
1.20
0.86
2.4
2.2
0.23
0.18
e6/l
0.23
78
669
323
3503
0.91
0.85
1.3
1.2
—
—
—
0
0
123
1070
1.16
0.83
1.4
1.3
—
—
—
0
0
46
363
1.27
0.83
1.2
1.4
—
6.92
—
0
5
20
138
1.45
0.81
2.0
2.1
75.30
77.43
%
0.26
20
133
8
47
1.70
0.80
1.0
1.0
—
—
—
0
0
6
33
1.82
0.79
5.5
7.8
—
—
—
0
0
16
106
1.51
0.79
2.6
3.6
335.86
177.07
umol/l
—
7
61
24
174
1.38
0.76
18.5
14.1
852.71
831.15
nmol/l
0.07
24
169
48
386
1.25
0.76
3.5
3.0
17.60
23.07
mg/l
0.38
27
233
173
1553
1.12
0.75
2.3
2.3
11.68
21.63
au/ml
2.80
13
173
9
54
1.67
0.74
2.2
2.3
—
—
—
0
0
9
55
1.64
0.73
1.1
1.1
—
—
—
0
0
161
1442
1.12
0.73
1.3
1.3
25.19
34.31
au/ml
—
8
54
5
25
2.00
0.72
2.0
1.9
—
—
—
0
0
7
39
1.80
0.72
3.1
2.2
—
—
—
0
0
43
533
0.80
0.71
1.1
1.1
0.09
0.24
u/ml
0.73
11
142
26
194
1.34
0.71
1.4
1.7
—
—
—
0
0
38
300
1.27
0.70
1.4
1.6
0.28
0.64
g/l
5.90
30
219
65
545
1.20
0.70
2.3
1.9
5.33
4.10
ug/l
0.28
57
466
335
3124
1.08
0.69
1.4
1.4
—
—
—
0
0
21
152
1.38
0.69
2.8
1.9
—
—
—
0
0
21
153
1.38
0.67
3.1
2.9
40495.24
39257.09
ug/l
0.24
21
153
938
9064
1.06
0.66
7.7
7.0
0.00
0.00
e9/l
0.23
776
7501
7
44
1.59
0.65
1.1
1.3
37.37
35.55
g/l
—
7
39
7
44
1.59
0.65
1.7
1.5
—
—
—
0
0
89
774
1.16
0.64
2.4
2.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
89
781
1.14
0.59
2.4
3.4
5.59
63.85
ug/l
0.62
59
528
29
228
1.28
0.58
1.3
1.2
—
—
—
0
0
5
88
0.57
0.56
1.0
1.1
—
—
—
0
0
24
185
1.30
0.56
1.1
1.2
1.56
1.32
u/ml
0.05
13
83
85
748
1.14
0.55
1.5
2.1
1.25
1.15
g/l
2.21
78
708
6
40
1.50
0.51
1.0
1.2
—
—
—
0
0
6
40
1.50
0.51
1.0
1.2
—
—
—
0
0
6
40
1.50
0.51
1.0
1.2
—
—
—
0
0
82
729
1.13
0.47
1.6
2.2
0.25
0.22
g/l
2.26
76
688
254
2386
1.07
0.47
1.2
1.2
—
—
—
0
0
25
201
1.25
0.45
1.4
1.4
—
—
—
0
0
13
95
1.37
0.43
1.2
2.5
1035.00
590.49
u/ml
0.50
13
95
14
104
1.35
0.43
1.1
2.3
17.29
281.92
ug/l
0.73
14
97
52
452
1.15
0.43
1.4
1.4
—
3.33
—
0
6
5
32
1.56
0.42
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.18
—
0
6
0
16
0.00
0.41
0.0
1.1
—
0.06
—
0
6
0
17
0.00
0.40
0.0
1.0
—
271.45
—
0
11
0
17
0.00
0.40
0.0
1.3
—
0.27
—
0
6
64
568
1.13
0.40
2.3
2.1
—
—
—
0
0
22
178
1.24
0.38
1.0
1.0
—
—
—
0
0
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
9
69
1.31
0.37
4.2
2.3
—
—
—
0
0
18
223
0.81
0.35
1.0
1.0
—
—
—
0
0
5
80
0.62
0.35
1.0
1.0
—
—
—
0
0
5
80
0.62
0.35
1.0
1.0
—
—
—
0
0
5
80
0.62
0.35
1.0
1.0
—
—
—
0
0
12
91
1.32
0.33
1.2
1.5
—
—
—
0
0
21
173
1.22
0.33
1.3
1.2
—
—
—
0
0
24
202
1.19
0.31
1.4
1.4
2.63
2.95
g/l
0.63
18
132
24
202
1.19
0.31
1.4
1.4
0.34
0.40
g/l
0.57
19
133
62
561
1.11
0.31
9.6
6.1
—
—
—
0
0
61
673
0.90
0.30
1.0
1.1
—
—
—
0
0
7
100
0.70
0.30
1.0
1.4
—
—
—
0
0
10
75
1.33
0.30
1.6
2.3
12.32
11.12
%
—
10
75
24
203
1.18
0.30
1.4
1.4
5.54
6.38
g/l
1.03
19
135
7
57
1.23
0.29
1.0
1.2
—
—
—
0
0
13
103
1.26
0.28
2.2
2.6
—
—
—
0
0
8
63
1.27
0.27
1.5
1.6
—
—
—
0
0
8
64
1.25
0.27
1.6
1.2
—
—
—
0
0
8
66
1.21
0.26
1.0
1.1
—
—
—
0
0
12
95
1.26
0.26
1.3
1.7
—
—
—
0
0
5
71
0.70
0.26
1.0
1.1
—
3.83
%
—
0
6
469
4818
0.97
0.26
1.5
1.5
—
—
—
0
0
5
75
0.67
0.25
1.8
1.9
—
140.99
—
0
12
22
188
1.17
0.25
1.1
1.1
10.93
5.68
iu/ml
—
6
49
18
151
1.19
0.25
1.2
1.1
—
—
—
0
0
9
77
1.17
0.24
1.7
1.4
—
—
—
0
0
5
38
1.32
0.23
1.4
1.2
—
—
—
0
0
54
495
1.09
0.23
2.6
2.7
—
—
—
0
0
72
670
1.08
0.22
1.0
1.1
3.15
5.72
u/ml
1.03
40
333
16
189
0.85
0.22
1.3
3.6
—
—
—
0
0
267
2582
1.04
0.22
1.5
1.5
—
—
—
0
0
20
172
1.16
0.22
1.2
1.3
1.60
1.74
mmol/l
0.82
20
158
14
116
1.21
0.22
2.2
2.8
1.41
1.73
g/24h
—
7
69
197
2048
0.96
0.21
1.3
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.01
—
0
5
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
26
230
1.13
0.20
1.1
1.4
—
—
—
0
0
14
117
1.20
0.20
1.1
1.2
1.57
1.58
g/l
0.05
14
117
72
769
0.93
0.20
1.1
1.1
0.88
2.05
u/ml
2.63
41
388
69
738
0.93
0.20
1.1
1.1
0.25
1.16
u/ml
2.38
20
322
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
—
—
0
0
52
562
0.92
0.20
1.3
1.3
—
—
—
0
0
7
60
1.17
0.17
1.0
1.1
—
—
—
0
0
14
119
1.18
0.17
2.5
2.3
—
—
—
0
0
1992
19824
1.02
0.17
13.9
10.9
332.23
332.39
g/l
0.33
1980
19656
11
92
1.20
0.16
1.5
1.9
106.18
105.90
mmol/l
0.06
11
92
11
92
1.20
0.16
1.5
1.9
3.72
3.91
mmol/l
1.58
11
92
8
73
1.10
0.15
1.6
2.9
—
—
—
0
0
9
78
1.15
0.15
4.0
2.6
48.67
48.66
%
—
9
50
237
2432
0.97
0.15
2.6
2.3
6.24
5.33
e6/l
0.43
120
1208
18
202
0.89
0.14
1.1
1.1
—
—
—
0
0
149
1539
0.97
0.14
1.1
1.2
—
—
—
0
0
21
231
0.91
0.12
1.0
1.0
—
—
—
0
0
58
610
0.95
0.12
1.1
1.1
3.15
6.70
u/ml
1.59
29
256
28
259
1.08
0.11
2.4
2.6
—
—
—
0
0
253
2580
0.98
0.11
2.4
2.2
0.73
1.29
e6/l
1.92
136
1355
256
2512
1.02
0.10
1.5
1.5
—
—
—
0
0
27
251
1.08
0.10
1.3
1.7
2543.20
8692.98
e6/l
1.99
20
188
13
145
0.90
0.09
1.0
1.1
—
—
—
0
0
69
665
1.04
0.09
1.1
1.1
—
—
—
0
0
76
786
0.97
0.08
1.1
1.1
1.88
6.90
u/ml
7.62
34
440
256
2520
1.02
0.08
1.5
1.5
—
—
—
0
0
39
410
0.95
0.08
2.6
3.6
58.08
56.74
%
0.34
39
410
5
61
0.82
0.08
1.8
2.2
—
14.44
—
0
8
5
62
0.81
0.08
1.2
1.4
—
—
—
0
0
5
65
0.77
0.08
1.8
1.8
—
—
—
0
0
19
176
1.08
0.07
1.1
1.1
—
—
—
0
0
22
235
0.94
0.07
1.1
1.6
—
—
—
0
0
9
88
1.02
0.07
1.6
1.9
—
—
—
0
0
45
434
1.04
0.06
1.3
1.4
—
—
—
0
0
44
425
1.04
0.05
2.4
2.3
—
—
—
0
0
17
159
1.07
0.05
1.8
2.0
—
—
—
0
0
13
120
1.08
0.05
1.1
1.1
—
—
—
0
0
39
403
0.97
0.04
2.5
3.4
4.41
3.97
e9/l
0.93
39
403
10
92
1.09
0.03
1.3
1.2
—
—
—
0
0
191
1922
0.99
0.02
1.4
1.3
206.88
238.50
miu/ml
0.68
101
1011
41
418
0.98
0.01
1.2
1.2
—
—
—
0
0
197
1979
1.00
0.01
1.3
1.3
—
—
—
0
0
11
104
1.06
0.01
1.2
1.1
—
—
—
0
0
11
104
1.06
0.01
1.0
1.1
—
—
—
0
0
10
99
1.01
0.00
1.2
1.2
—
—
—
0
0
23
225
1.02
0.00
1.3
1.6
—
—
—
0
0
13
126
1.03
0.00
1.6
1.3
58.92
66.52
umol/l
1.73
13
126
13
128
1.02
0.00
1.4
1.3
—
—
—
0
0
88
878
1.00
0.00
1.2
1.1
1.69
2.68
u/ml
0.71
49
442
224
2237
1.00
0.00
1.7
1.7
—
—
—
0
0
14
137
1.02
0.00
3.1
3.2
16.89
51.25
u/ml
1.57
14
137
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
0.18
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
56
0.89
-0.00
1.2
2.5
—
—
—
0
0
7
79
0.89
-0.00
1.0
1.3
—
—
—
0
0
18
180
1.00
-0.00
1.2
1.4
—
—
—
0
0
28
280
1.00
-0.00
2.2
3.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
34.75
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
49
1.02
-0.00
29.6
24.5
127.20
103.21
ug/l
—
5
42
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.1
—
—
—
0
0
14
140
1.00
-0.00
1.4
1.7
63.63
45.02
%
—
8
84
0
7
0.00
-0.00
0.0
1.1
—
205.44
—
0
7

Mortality – FinRegistry

Association

Association between endpoint E4_PCOS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PCOS 1.36 [1.07, 1.73] 0.012
Birth year 0.992 [0.98, 1.0] 0.066

During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 10334 females with E4_PCOS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_PCOS.

N-year risk Females Males
1 0.115% No data
5 0.624% No data
10 1.619% No data
15 3.275% No data
20 6.043% No data

Relationships between endpoints

Index endpoint: E4_PCOS – Polycystic ovarian syndrome

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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