No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
833 |
4. Check minimum number of eventsNone |
833 |
5. Include endpointsNone |
833 |
6. Filter based on genotype QC (FinnGen only) |
808 |
Control definitions (FinnGen only)
- Control exclude
- H7_EYEOTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Anomalies of pupillary function
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5859 | 3670 | 2172 |
| Only index persons | 5135 | 3304 | 1831 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 38.54 | 40.94 | 34.48 |
| Only index persons | 41.34 | 42.94 | 38.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 808 | 578 | 230 |
| Unadjusted period prevalence (%) | 0.18 | 0.21 | 0.11 |
| Median age at first event (years) | 47.02 | 46.31 | 48.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 833
- Matched controls
- 8330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H57.0
ICD-10 Finland
Anomalies of pupillary function
+∞
307.7
806
*
AA1AD
NOMESCO Finland
CT of head and brain
2.8
37.8
261
1176
G90.2
ICD-10 Finland
Horner syndrome
47.8
34.0
41
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
30.6
204
891
H57.1
ICD-10 Finland
Ocular pain
5.5
28.3
56
107
XCK00
NOMESCO Finland
Perimetry
3.9
23.4
72
197
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
20.4
96
344
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
20.1
107
410
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
5.0
19.6
43
90
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.0
19.6
96
352
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.4
17.3
44
104
R51.80
ICD-10 Finland
Headache
2.2
17.2
175
904
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
16.4
96
386
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
15.9
74
263
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
15.7
98
407
R42
ICD-10 Finland
Dizziness and giddiness
2.0
14.7
183
1014
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
14.4
344
2350
Q13.2
ICD-10 Finland
Other congenital malformations of iris
34.7
13.5
17
5
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.9
13.1
39
104
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.5
12.9
45
134
M79.6
ICD-10 Finland
Pain in limb
1.7
12.4
356
2534
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
11.8
193
1164
F29
ICPC
Eye symptom/complaint other
2.3
11.5
95
447
37834
ICD-8 Finland
Other diseases of eye, Deformatio pupillae. Anisocoria. Miosis. Mydriasis
+∞
11.5
11
*
H53.2
ICD-10 Finland
Diplopia
3.6
11.3
37
106
R20.2
ICD-10 Finland
Paraesthesia of skin
2.4
10.9
76
332
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
10.6
327
2345
L01
ICPC
Neck symptom/complaint
1.9
10.3
146
839
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
23.7
10.3
14
6
A02BC02
ATC
pantoprazole; systemic
1.6
10.1
516
4170
R03AC02
ATC
salbutamol; inhalant
1.6
10.1
472
3734
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.4
9.8
35
106
R02
ICPC
Shortness of breath/dyspnoea
2.0
9.7
108
570
TAB00
NOMESCO Finland
Lumbar puncture
2.8
9.7
50
188
N06AX11
ATC
mirtazapine; oral
1.6
9.6
282
1987
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
9.5
229
1533
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
9.3
313
2276
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.3
9.3
72
330
S06.0
ICD-10 Finland
Concussion
2.0
9.2
102
537
R01AD58
ATC
fluticasone, combinations; nasal
1.7
9.1
227
1531
R06.0
ICD-10 Finland
Dyspnoea
1.7
9.0
199
1301
N06AX26
ATC
vortioxetine; oral
2.2
8.8
79
384
PA6AD
NOMESCO Finland
CT of neck arteries
3.6
8.6
28
80
A02BA02
ATC
ranitidine; systemic
1.8
8.5
137
817
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
20.3
8.5
12
6
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
8.3
118
677
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.6
8.2
20
31
A02BC05
ATC
esomeprazole; systemic
1.6
8.2
308
2282
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
8.2
207
1396
R52.9
ICD-10 Finland
Pain, unspecified
2.1
8.2
85
437
SPAT1301
SPAT
No procedures
1.6
7.8
240
1697
G44.2
ICD-10 Finland
Tension-type headache
1.8
7.8
127
760
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.9
7.7
108
616
R03DC03
ATC
montelukast; oral
1.7
7.7
145
904
M54.5
ICD-10 Finland
Low back pain
1.5
7.6
291
2156
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.4
7.6
51
219
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.5
202
1383
H02AB06
ATC
prednisolone; systemic
1.5
7.4
348
2690
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.8
7.4
22
59
N05AH04
ATC
quetiapine; oral
1.7
7.4
159
1027
J01AA02
ATC
doxycycline; systemic
1.5
7.4
589
5079
N03AX12
ATC
[U] gabapentin; oral
1.8
7.3
126
766
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.1
156
1011
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.8
7.1
35
129
S16
ICPC
Bruise/contusion
3.1
7.1
29
96
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.0
709
6415
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.9
339
2634
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
6.9
95
538
R60.0
ICD-10 Finland
Localized oedema
1.9
6.9
84
458
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
6.9
86
473
K04.0
ICD-10 Finland
Pulpitis
1.9
6.8
93
526
SPAT1260
SPAT
Consultation of another employee
1.7
6.8
135
853
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.5
6.8
40
162
M01AB05
ATC
diclofenac; systemic, rectal
1.5
6.8
510
4304
H02.4
ICD-10 Finland
Ptosis of eyelid
3.1
6.7
27
89
N06AX16
ATC
venlafaxine; oral
1.7
6.7
128
801
M25.5
ICD-10 Finland
Pain in joint
1.5
6.6
263
1956
R06AX27
ATC
desloratadine; oral
1.5
6.5
253
1871
R55
ICD-10 Finland
Syncope and collapse
1.9
6.5
79
430
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
6.5
119
735
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
6.5
388
3123
P06
ICPC
Sleep disturbance
1.8
6.4
101
596
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
7.5
6.4
14
19
UJF32
NOMESCO Finland
Coloscopy
1.6
6.4
172
1171
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
6.4
41
173
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.8
6.3
87
495
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.2
328
2571
H01
ICPC
Ear pain/earache
1.7
6.1
109
668
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
6.1
43
190
N17
ICPC
Vertigo/dizziness
1.8
6.0
90
523
L29.9
ICD-10 Finland
Pruritus, unspecified
3.0
6.0
26
89
L17
ICPC
Foot/toe symptom/complaint
1.5
6.0
222
1620
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
312
1784
2.20
24.90
2.2
2.1
140.21
217.93
u/l
1.29
295
1677
492
3699
1.81
15.12
5.2
4.6
6.34
6.57
mmol/l
1.83
452
3398
166
904
2.04
13.93
1.8
2.0
29.36
29.57
s
0.13
160
877
410
2975
1.74
13.74
6.7
6.6
1.21
1.22
mmol/l
0.43
354
2549
374
2704
1.70
12.25
5.8
5.9
1.21
1.22
mmol/l
1.41
342
2477
603
4987
1.76
11.68
4.3
3.8
10.45
10.75
mm/h
0.23
568
4625
360
2621
1.66
11.18
11.8
10.8
1.14
1.17
inr
0.29
112
801
765
6904
2.32
10.45
16.1
13.0
139.60
139.64
mmol/l
0.20
755
6707
766
6926
2.32
10.26
16.2
13.0
3.93
3.94
mmol/l
0.45
752
6714
599
5036
1.67
9.92
7.5
6.8
75.97
77.21
u/l
0.30
574
4733
345
2550
1.60
9.68
4.2
4.5
36.19
36.22
g/l
0.04
328
2402
424
3300
1.58
9.49
5.8
5.8
12.57
10.78
umol/l
0.48
392
3118
177
1106
1.76
9.44
4.2
3.5
252.00
409.48
ng/l
0.43
118
761
276
1972
1.60
8.73
2.7
2.4
57.10
58.83
u/l
0.24
259
1836
759
6919
2.09
8.61
15.1
11.8
19.59
21.56
mg/l
0.99
611
5388
300
2192
1.58
8.59
3.2
3.1
58.70
52.95
ng/l
0.06
167
1322
221
1530
1.60
7.84
1.8
1.7
1.59
1.00
mg/l
0.46
154
1158
39
150
2.68
7.30
1.0
1.4
5.21
11.16
e6/l
0.42
28
116
39
150
2.68
7.30
1.0
1.5
500.63
121.00
e6/l
0.60
30
120
478
3970
1.48
6.98
9.1
8.6
3.87
4.02
e9/l
0.96
418
3488
84
456
1.94
6.96
3.0
3.4
4.50
4.62
pmol/l
0.51
74
401
627
5513
1.56
6.89
5.0
4.1
14.65
14.57
pmol/l
0.30
585
5076
712
6465
1.70
6.72
6.0
4.8
1.84
2.02
mu/l
0.46
666
6005
317
2448
1.48
6.60
1.9
1.8
99.64
96.35
pmol/l
0.59
166
1275
72
381
1.97
6.43
2.7
2.8
97.70
165.68
ng/l
1.91
66
345
412
3361
1.45
6.37
6.5
5.9
29.73
29.01
%
0.62
395
3172
296
2270
1.47
6.32
3.6
3.1
30.83
30.20
u/l
0.14
278
2170
143
934
1.64
6.31
1.7
1.8
—
—
—
0
0
19
53
3.65
6.06
1.0
1.1
—
—
—
0
0
243
1810
1.48
5.95
1.3
1.3
0.77
1.77
u/ml
1.97
59
502
143
949
1.61
5.90
2.9
3.6
0.82
0.82
mmol/l
0.37
130
895
405
3327
1.42
5.85
6.4
5.7
55.75
56.39
%
0.54
388
3141
141
942
1.60
5.65
2.2
2.3
94.72
122.90
ug/g
0.68
112
735
227
1691
1.47
5.49
1.7
1.6
—
—
—
0
0
190
1378
1.49
5.23
1.4
1.5
21.37
21.29
nmol/l
0.02
169
1192
97
601
1.69
5.22
7.3
9.1
5.13
5.13
kpa
0.01
91
576
97
601
1.69
5.22
7.2
9.1
12.19
12.48
kpa
0.27
91
578
102
642
1.67
5.18
1.6
1.7
—
—
—
0
0
216
1610
1.46
5.17
2.1
2.1
2.35
2.95
mg/l
4.72
187
1388
96
596
1.69
5.13
7.3
9.2
1.38
1.08
mmol/l
0.39
77
482
204
1512
1.46
5.01
3.4
3.6
1.02
1.02
kg/l
0.22
30
203
779
7366
1.89
4.96
11.3
9.3
25.91
25.94
u/l
0.01
752
7122
705
6511
1.54
4.78
4.1
4.0
5.78
5.79
mmol/l
0.05
651
5988
18
57
3.21
4.78
1.0
1.1
218.50
233.43
mg/l
0.19
18
46
280
2217
1.40
4.74
3.4
2.9
—
—
—
0
0
101
649
1.63
4.74
1.7
1.8
—
—
—
0
0
815
7851
2.76
4.73
22.3
17.5
45.47
40.26
%
0.48
744
7429
213
1610
1.43
4.68
4.4
3.6
93.33
94.21
%
0.19
206
1565
171
1246
1.47
4.55
1.3
1.3
19.45
29.94
iu/ml
1.44
59
415
815
7860
2.71
4.55
22.1
17.4
4.50
4.51
e12/l
0.44
801
7658
674
6189
1.47
4.49
17.8
14.2
14.21
14.48
%
0.75
663
6092
815
7863
2.69
4.48
22.3
17.5
135.12
135.39
g/l
0.23
810
7756
105
691
1.59
4.47
7.7
7.2
103.89
104.21
mmol/l
0.28
105
691
402
3400
1.35
4.42
3.6
3.4
0.00
0.00
estimate
0.50
78
689
814
7855
2.59
4.36
22.2
17.4
256.88
257.26
e9/l
0.06
802
7669
401
3402
1.34
4.27
5.1
4.6
0.00
0.00
estimate
0.50
73
657
192
1453
1.42
4.15
2.5
3.0
914.47
927.63
ng/l
0.02
153
1203
17
57
3.02
4.14
1.1
1.1
14.22
6.48
iu/ml
—
9
12
264
2111
1.37
4.10
2.9
3.2
2.34
2.36
mmol/l
1.34
233
1880
168
1251
1.43
3.96
1.7
1.6
434.20
31637804.77
pmol/l
1.57
143
1081
401
3439
1.32
3.82
3.7
3.4
0.00
0.01
estimate
0.80
73
637
386
3293
1.32
3.81
2.7
2.7
88.74
93.35
ug/l
0.24
362
3075
162
1207
1.42
3.80
1.3
1.3
11.48
9.74
u/ml
0.10
67
476
45
767
0.56
3.53
1.6
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
138
2.14
3.53
3.1
3.0
0.35
0.32
u/ml
0.24
17
71
19
77
2.50
3.31
1.0
1.1
—
—
—
0
0
89
612
1.51
3.15
3.8
2.4
31.24
112.98
u/l
0.52
78
511
24
111
2.20
3.15
1.6
1.4
—
—
—
0
0
109
781
1.46
3.15
2.3
2.0
—
—
—
0
0
102
724
1.47
3.09
5.4
6.0
—
—
—
0
0
11
30
3.70
3.09
1.0
1.0
225.33
266.68
ng/l
—
6
19
11
30
3.70
3.09
1.0
1.0
854.00
709.16
ng/l
—
6
19
11
30
3.70
3.09
1.0
1.0
23.83
37.84
ng/l
—
6
17
35
191
1.87
2.97
1.7
1.9
4.69
5.59
iu/l
0.15
15
68
61
391
1.60
2.95
1.8
2.3
11.51
12.24
nmol/l
0.22
56
361
525
4758
1.28
2.94
3.2
3.0
45.86
42.80
u/l
0.23
488
4503
311
2655
1.27
2.82
3.5
3.5
—
—
—
0
0
89
627
1.47
2.82
1.9
1.9
—
—
—
0
0
134
1019
1.38
2.78
3.4
2.5
1.25
1.06
e6/l
0.16
74
560
99
717
1.43
2.72
2.7
2.8
10.21
6.73
umol/l
0.27
84
617
212
1740
1.29
2.60
1.7
1.6
1.40
1.37
mmol/l
0.19
185
1497
62
413
1.54
2.57
1.7
1.6
—
—
—
0
0
42
254
1.69
2.57
1.5
1.3
—
—
—
0
0
5
7
7.18
2.55
1.2
1.1
—
—
—
0
0
78
547
1.47
2.54
2.2
2.4
0.21
0.22
g/l
0.72
72
521
13
50
2.63
2.54
1.0
1.1
1.15
1.10
u/l
—
6
24
646
6055
1.30
2.54
5.2
5.0
38.72
38.88
mmol/mol
0.17
608
5670
85
608
1.44
2.50
1.2
1.2
121.16
153.49
iu/ml
0.38
37
252
16
69
2.34
2.49
1.0
1.1
—
—
—
0
0
564
5206
1.26
2.47
3.9
3.5
—
—
—
0
0
48
304
1.61
2.47
1.6
1.7
—
—
—
0
0
22
110
2.03
2.42
2.7
2.0
13.06
13.15
%
0.18
22
110
207
1711
1.28
2.39
3.5
2.8
0.22
0.39
e6/l
1.03
151
1286
89
652
1.41
2.31
1.8
2.1
375.88
374.10
nmol/l
0.03
77
608
361
3193
1.23
2.28
2.4
2.5
—
—
—
0
0
35
209
1.70
2.27
1.5
1.3
—
—
—
0
0
0
59
0.00
2.25
0.0
2.2
—
2.14
—
0
29
134
1054
1.32
2.24
2.7
2.6
2.43
2.44
mmol/l
0.26
119
923
16
73
2.22
2.22
1.0
1.1
—
—
—
0
0
126
984
1.33
2.21
1.8
1.6
1123.22
1201.69
nmol/l
0.53
98
754
71
505
1.44
2.18
7.2
8.1
1.52
1.36
mmol/l
0.35
65
494
65
457
1.46
2.12
1.0
1.0
—
—
—
0
0
34
207
1.67
2.07
1.4
1.1
—
—
—
0
0
74
537
1.41
2.05
4.4
3.9
5.98
5.82
kpa
0.70
66
518
29
170
1.73
2.02
1.4
1.5
—
—
—
0
0
49
329
1.52
2.01
1.5
1.4
247.26
246.64
miu/ml
0.01
25
169
119
936
1.32
2.00
1.8
1.8
1.50
1.44
%
0.36
103
854
21
112
1.90
1.97
1.3
1.2
1.78
5.86
u/ml
—
9
50
16
77
2.10
1.97
2.3
2.3
—
—
—
0
0
73
533
1.41
1.96
4.4
3.9
2.04
1.87
mmol/l
0.16
58
424
21
114
1.86
1.88
1.2
1.1
—
—
—
0
0
35
221
1.61
1.88
1.2
1.1
3.94
6.80
u/ml
—
5
37
6
17
3.55
1.84
1.2
1.3
—
—
—
0
0
5
12
4.19
1.82
1.0
1.5
—
—
—
0
0
67
489
1.40
1.82
2.9
2.4
80.73
72.07
ml/min/173m2
1.00
30
202
316
2809
1.20
1.79
2.2
2.3
73.27
75.28
nmol/l
0.73
293
2552
62
449
1.41
1.76
2.2
2.2
5991.00
3946.61
u/l
0.20
25
185
28
170
1.67
1.75
1.4
1.4
301.46
315.90
ug/g
0.10
13
98
62
451
1.40
1.73
4.2
3.3
4.66
4.66
kpa
0.01
56
436
145
1196
1.26
1.69
2.3
2.1
—
—
—
0
0
119
959
1.28
1.68
3.6
2.6
2.97
3.13
e6/l
0.09
59
504
6
19
3.17
1.66
5.2
5.9
—
—
—
0
0
13
62
2.11
1.66
1.4
1.6
59.88
58.28
%
—
8
43
20
112
1.81
1.65
1.3
1.2
1.25
4.07
u/ml
—
8
41
217
1874
1.21
1.65
3.6
2.9
18.92
96.08
e6/l
1.47
159
1428
190
1621
1.22
1.63
3.2
3.3
435.35
259.91
mg/l
0.18
109
1039
706
6796
1.25
1.57
4.8
4.4
2.84
2.83
mmol/l
0.15
652
6346
0
42
0.00
1.53
0.0
1.7
—
1.28
—
0
33
62
462
1.37
1.52
2.0
3.4
1.23
1.23
mmol/l
0.18
55
402
182
1557
1.22
1.52
2.4
2.6
6940.31
5612.16
umol/l
0.13
157
1380
15
79
1.92
1.50
1.1
1.5
—
—
—
0
0
15
79
1.92
1.50
1.1
1.5
—
—
—
0
0
156
1316
1.23
1.50
2.3
2.2
—
—
—
0
0
61
455
1.37
1.49
1.2
1.3
101.44
33.06
au/ml
—
5
32
696
6699
1.24
1.49
4.3
4.0
4.76
4.74
mmol/l
0.24
641
6292
10
45
2.24
1.47
1.0
1.5
—
—
—
0
0
58
432
1.37
1.44
1.2
1.5
49.35
24.50
iu/l
1.58
42
369
19
110
1.74
1.44
1.1
1.6
—
—
—
0
0
19
110
1.74
1.44
1.1
1.6
—
—
—
0
0
111
911
1.25
1.37
4.5
4.0
22.48
21.34
%
0.29
48
398
113
933
1.24
1.33
1.9
2.3
13.57
13.59
umol/l
0.01
106
868
216
1903
1.18
1.31
3.8
3.1
7.39
7.64
mmol/l
0.31
184
1636
6
24
2.51
1.30
1.2
1.2
—
—
—
0
0
16
91
1.77
1.29
1.3
1.4
0.60
0.54
nmol/l
0.26
16
84
19
114
1.68
1.29
1.2
1.1
—
—
—
0
0
151
1293
1.20
1.26
2.5
2.4
5.74
7.28
e6/l
0.84
139
1157
29
196
1.50
1.23
4.3
2.8
3035.49
955.58
u/ml
0.30
29
170
36
256
1.42
1.19
1.8
1.8
—
—
—
0
0
26
173
1.52
1.19
1.2
1.8
54.85
38.12
nmol/l
1.18
26
167
665
6411
1.18
1.18
3.7
3.6
1.26
1.26
mmol/l
0.07
613
5964
194
1711
1.17
1.16
3.8
3.9
11.83
8.94
mg/mmol
0.20
115
1074
135
1156
1.20
1.13
5.3
4.3
2.66
2.32
ug/l
0.19
119
1047
14
80
1.76
1.13
1.3
1.2
—
—
—
0
0
16
96
1.68
1.10
1.9
1.3
—
—
—
0
0
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
84
687
1.25
1.10
3.2
2.8
0.71
0.78
ug/l
0.37
57
408
21
137
1.55
1.06
1.2
1.5
108.54
110.58
u/ml
—
8
31
17
106
1.62
1.03
1.0
1.5
—
—
—
0
0
202
1808
1.15
1.00
4.0
3.7
0.00
0.00
estimate
1.08
74
650
18
115
1.58
1.00
1.0
1.1
—
—
—
0
0
13
76
1.72
0.99
1.0
1.4
—
—
—
0
0
34
249
1.38
0.99
1.2
1.6
25.06
9.71
u/l
0.62
27
209
30
215
1.41
0.99
1.8
1.8
—
—
—
0
0
9
50
1.81
0.97
1.3
1.5
—
—
—
0
0
15
94
1.61
0.91
1.0
1.4
—
—
—
0
0
687
6681
1.16
0.90
4.3
4.0
1.49
1.49
mmol/l
0.07
639
6247
8
42
1.91
0.88
1.0
1.4
—
19.20
—
0
10
8
43
1.87
0.87
1.0
1.3
—
28.33
—
0
6
73
607
1.22
0.86
2.9
3.0
—
—
—
0
0
8
45
1.79
0.84
1.0
1.4
—
290.00
—
0
5
23
319
0.71
0.84
1.6
1.4
—
—
—
0
0
10
57
1.76
0.84
1.1
1.4
—
—
—
0
0
8
46
1.75
0.82
1.0
1.1
—
—
—
0
0
31
232
1.35
0.82
1.6
1.8
—
—
—
0
0
175
1574
1.14
0.82
1.5
1.4
2.12
2.22
g/l
0.39
106
972
16
105
1.53
0.82
3.4
2.5
16.60
16.44
%
—
7
60
25
181
1.39
0.80
1.2
1.1
2.51
3.84
u/ml
—
10
97
54
438
1.25
0.80
2.6
2.2
5.42
7.42
ug/l
0.73
44
393
20
139
1.45
0.80
3.1
3.8
54.85
57.01
%
0.23
20
139
22
156
1.42
0.79
1.1
1.6
—
—
—
0
0
663
6448
1.14
0.79
13.0
10.6
89.46
87.40
ml/min/173m2
1.66
563
5219
16
106
1.52
0.79
1.0
1.1
125.81
115.90
%
0.95
16
96
0
25
0.00
0.79
0.0
1.3
—
8.34
—
0
25
31
234
1.34
0.78
1.8
2.0
—
—
—
0
0
15
99
1.52
0.76
1.2
1.2
—
—
—
0
0
22
158
1.40
0.75
1.2
1.1
3.98
1.91
u/ml
—
10
86
5
24
2.09
0.74
1.0
1.3
—
—
—
0
0
172
1556
1.13
0.74
2.2
2.1
—
—
—
0
0
24
321
0.74
0.72
1.6
1.4
—
—
—
0
0
21
151
1.40
0.71
1.0
1.6
—
—
—
0
0
24
320
0.74
0.71
1.6
1.4
—
—
—
0
0
24
319
0.75
0.70
1.6
1.4
—
—
—
0
0
50
605
0.82
0.69
1.6
1.5
—
—
—
0
0
19
136
1.41
0.67
1.5
1.6
8776.93
15558.98
e6/l
0.64
14
99
29
224
1.31
0.65
1.3
1.5
0.01
0.10
iu/ml
—
6
36
97
855
1.15
0.63
1.9
2.3
2.44
2.42
g/l
0.17
88
794
8
50
1.61
0.61
1.4
1.2
—
—
—
0
0
28
218
1.29
0.61
1.1
1.2
—
—
—
0
0
28
218
1.29
0.61
1.1
1.2
—
—
—
0
0
19
139
1.38
0.61
1.4
1.4
17.90
21.78
u/l
0.27
19
120
164
1500
1.12
0.60
1.5
1.5
—
—
—
0
0
8
51
1.57
0.60
2.5
3.3
—
—
—
0
0
15
105
1.44
0.60
1.3
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
2.0
—
75.28
—
0
22
33
409
0.80
0.59
1.5
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
341.13
—
0
16
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
39
320
1.23
0.57
2.4
1.7
—
—
—
0
0
6
36
1.67
0.56
1.2
2.8
654.33
692.44
u/ml
—
6
36
6
38
1.58
0.54
1.0
1.2
—
—
—
0
0
28
349
0.80
0.54
1.6
1.5
—
—
—
0
0
11
156
0.70
0.50
1.1
1.2
—
—
—
0
0
20
155
1.30
0.47
1.6
1.6
0.33
0.33
nmol/l
0.03
13
127
7
48
1.46
0.47
1.3
1.4
—
—
—
0
0
28
341
0.81
0.45
1.7
1.7
2.69
3.01
mg/l
0.11
18
251
20
156
1.29
0.45
3.0
2.6
—
—
—
0
0
35
295
1.19
0.42
1.3
1.4
—
—
—
0
0
13
96
1.36
0.41
1.2
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
20
159
1.26
0.40
1.2
1.3
—
—
—
0
0
5
34
1.47
0.40
1.0
2.4
11.82
266.22
ug/l
—
5
28
16
125
1.29
0.37
1.1
1.0
2.22
2.16
u/ml
—
10
60
19
153
1.25
0.35
1.2
1.4
222.50
239.21
u/ml
—
10
92
6
44
1.37
0.34
1.3
1.5
—
—
—
0
0
7
98
0.71
0.31
6.6
4.1
35.76
409.25
u/ml
—
7
93
18
148
1.22
0.29
5.5
2.2
0.73
0.83
nmol/l
0.28
12
126
8
109
0.73
0.29
1.0
1.6
—
—
—
0
0
23
195
1.18
0.28
3.7
4.1
1.35
1.29
mmol/l
0.14
23
190
8
62
1.29
0.28
3.5
3.7
—
—
—
0
0
57
520
1.10
0.26
4.3
4.2
10.57
16.14
ug/l
0.21
44
423
17
143
1.19
0.23
1.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
8.16
—
0
10
0
10
0.00
0.21
0.0
2.7
—
0.60
—
0
10
0
10
0.00
0.21
0.0
2.3
—
43.58
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
0.35
—
0
8
0
14
0.00
0.20
0.0
2.6
—
0.07
—
0
8
17
146
1.17
0.19
3.2
2.2
0.00
0.00
g/l
-0.00
17
138
20
175
1.15
0.18
2.9
2.3
1.12
0.95
g/l
0.07
20
159
7
63
1.11
0.17
1.4
1.3
1.82
1.41
nmol/l
—
7
55
17
148
1.15
0.17
3.2
2.2
0.00
0.00
g/l
-0.00
17
139
20
225
0.89
0.16
1.5
1.5
—
—
—
0
0
13
151
0.86
0.16
2.0
1.5
—
—
—
0
0
50
468
1.07
0.15
1.3
1.3
—
—
—
0
0
10
83
1.21
0.15
1.2
1.1
—
—
—
0
0
11
93
1.19
0.14
1.1
1.2
—
—
—
0
0
38
358
1.06
0.10
1.6
1.4
—
—
—
0
0
12
135
0.89
0.10
1.9
2.2
16.63
125.70
ug/min
—
7
83
5
46
1.09
0.09
1.4
1.3
35.84
32.97
nmol/l
—
5
37
40
379
1.06
0.09
4.4
3.9
1.21
1.64
mmol/l
0.29
33
282
24
258
0.93
0.09
1.5
1.7
—
—
—
0
0
6
57
1.05
0.08
1.2
1.6
—
—
—
0
0
6
57
1.05
0.08
1.2
1.6
—
—
—
0
0
6
57
1.05
0.08
1.2
1.6
—
—
—
0
0
7
65
1.08
0.08
1.4
1.8
—
—
—
0
0
17
156
1.09
0.08
1.5
1.3
—
—
—
0
0
6
72
0.83
0.07
1.0
1.5
—
—
—
0
0
20
186
1.08
0.07
2.9
2.2
2.61
2.90
g/l
1.34
20
173
21
197
1.07
0.06
1.3
1.2
3.90
10.56
u/ml
—
7
35
17
158
1.08
0.06
3.2
2.2
0.04
0.03
g/l
0.02
17
149
28
294
0.95
0.06
1.5
1.4
—
—
—
0
0
21
198
1.06
0.05
2.9
2.1
—
—
—
0
0
21
198
1.06
0.05
2.9
2.1
6.71
7.29
g/l
1.10
21
185
21
198
1.06
0.05
2.9
2.1
3.44
3.56
g/l
0.19
21
185
29
303
0.96
0.05
1.5
1.5
—
—
—
0
0
75
766
0.98
0.04
4.5
4.0
32.10
31.87
%
0.08
51
520
21
199
1.06
0.04
1.6
1.3
96.43
160.47
pmol/l
0.40
21
194
11
119
0.92
0.04
1.9
1.7
—
—
—
0
0
80
786
1.02
0.03
2.0
2.3
19.31
22.96
%
1.86
69
680
17
161
1.06
0.03
3.2
2.1
37.32
39.03
g/l
0.76
17
148
32
312
1.03
0.02
1.7
1.9
—
—
—
0
0
19
186
1.02
0.00
3.0
2.2
10.66
10.68
g/l
0.01
19
172
14
138
1.01
0.00
1.3
1.2
—
—
—
0
0
14
137
1.02
0.00
2.4
1.8
—
—
—
0
0
13
131
0.99
0.00
1.5
1.2
—
—
—
0
0
12
125
0.96
0.00
1.3
1.3
—
—
—
0
0
12
125
0.96
0.00
1.3
1.3
—
—
—
0
0
6
66
0.91
0.00
1.0
1.2
—
—
—
0
0
6
66
0.91
0.00
1.2
1.1
—
—
—
0
0
9
91
0.99
-0.00
1.0
1.4
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.2
—
—
—
0
0
9
90
1.00
-0.00
1.0
1.4
—
—
—
0
0
5
59
0.85
-0.00
1.2
1.7
—
—
—
0
0
9
92
0.98
-0.00
1.0
1.3
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2.01
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
-0.00
1.0
1.4
—
—
—
0
0
8
89
0.90
-0.00
1.1
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
17
170
1.00
-0.00
1.5
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
79
1.01
-0.00
1.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
1.2
2.1
—
—
—
0
0
6
61
0.98
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
56
0.89
-0.00
1.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.3
1.2
—
—
—
0
0
6
60
1.00
-0.00
1.3
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.3
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
90
1.00
-0.00
1.0
1.4
—
—
—
0
0
9
91
0.99
-0.00
1.0
1.3
—
—
—
0
0
7
69
1.01
-0.00
1.1
1.6
—
—
—
0
0
6
61
0.98
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
1.15
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_ANOMAPUPFUNC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.182 [0.96, 1.46] | 0.124 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 169 out of 2968 females with H7_ANOMAPUPFUNC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.53 [1.15, 2.03] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 1746 males with H7_ANOMAPUPFUNC died.
Mortality risk
Mortality risk for people of age
years, who have H7_ANOMAPUPFUNC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.289% |
| 5 | 0.718% | 1.814% |
| 10 | 1.711% | 4.479% |
| 15 | 3.221% | 8.656% |
| 20 | 5.523% | 14.409% |
Relationships between endpoints
↥Index endpoint: H7_ANOMAPUPFUNC – Anomalies of pupillary function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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