No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
771 |
4. Check minimum number of eventsNone |
771 |
5. Include endpointsNone |
771 |
6. Filter based on genotype QC (FinnGen only) |
771 |
Control definitions (FinnGen only)
- Control exclude
- H7_EYEOTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Anomalies of pupillary function
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5859 | 3670 | 2172 |
| Only index persons | 5135 | 3304 | 1831 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 38.54 | 40.94 | 34.48 |
| Only index persons | 41.34 | 42.94 | 38.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 771 | 548 | 223 |
| Unadjusted period prevalence (%) | 0.16 | 0.19 | 0.10 |
| Median age at first event (years) | 45.97 | 45.95 | 46.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 675
- Matched controls
- 6749
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H57.0
ICD-10 Finland
Anomalies of pupillary function
4503599627370496.0
323.0
650
*
G90.2
ICD-10 Finland
Horner syndrome
41.9
26.0
32
8
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
24.6
156
597
AA1AD
NOMESCO Finland
CT of head and brain
2.7
22.0
175
769
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
15.9
81
261
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.1
15.1
89
317
H57.1
ICD-10 Finland
Ocular pain
6.6
14.2
36
57
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.4
13.4
67
213
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
13.1
71
240
R51.80
ICD-10 Finland
Headache
2.3
12.4
130
641
R42
ICD-10 Finland
Dizziness and giddiness
2.2
12.2
137
697
XCK00
NOMESCO Finland
Perimetry
3.4
11.8
57
177
37834
ICD-8 Finland
Other diseases of eye, Deformatio pupillae. Anisocoria. Miosis. Mydriasis
+∞
11.5
11
*
Q13.2
ICD-10 Finland
Other congenital malformations of iris
35.7
11.3
14
*
R03AC02
ATC
salbutamol; inhalant
1.7
11.0
371
2787
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.5
10.9
38
89
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.0
10.6
33
68
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
10.0
52
171
R20.2
ICD-10 Finland
Paraesthesia of skin
3.0
10.0
59
212
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
10.0
149
848
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
9.7
69
279
H53.2
ICD-10 Finland
Diplopia
5.6
9.6
27
50
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
9.5
252
1738
A02BA02
ATC
ranitidine; systemic
2.1
9.2
115
609
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.5
8.8
30
69
L01
ICPC
Neck symptom/complaint
2.1
8.7
101
519
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
8.6
172
1078
N06AX11
ATC
mirtazapine; oral
1.7
8.6
206
1369
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
27.9
8.5
11
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
8.5
238
1654
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.3
149
901
M79.6
ICD-10 Finland
Pain in limb
1.7
8.3
230
1594
M01AB05
ATC
diclofenac; systemic, rectal
1.6
7.7
410
3335
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.6
7.5
18
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.2
241
1740
Z71.8
ICD-10 Finland
Other specified counselling
1.7
7.1
165
1076
M25.5
ICD-10 Finland
Pain in joint
1.7
7.1
191
1302
G44.2
ICD-10 Finland
Tension-type headache
2.0
7.1
97
531
F29
ICPC
Eye symptom/complaint other
2.3
7.1
63
286
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
7.0
71
344
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
6.9
153
982
N05AH04
ATC
quetiapine; oral
1.8
6.9
115
677
TAB00
NOMESCO Finland
Lumbar puncture
3.0
6.8
37
128
S06.0
ICD-10 Finland
Concussion
2.1
6.8
76
385
R52.9
ICD-10 Finland
Pain, unspecified
2.4
6.8
57
253
H50.2
ICD-10 Finland
Vertical strabismus
16.9
6.8
10
6
R06AX27
ATC
desloratadine; oral
1.6
6.7
197
1371
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
6.6
318
2488
K04.0
ICD-10 Finland
Pulpitis
2.1
6.6
74
375
M54.5
ICD-10 Finland
Low back pain
1.6
6.6
212
1508
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.5
277
2103
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
6.5
91
505
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.0
6.3
76
395
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.0
6.3
80
428
S01GX02
ATC
levocabastine; ophthalmic
2.5
6.0
46
195
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
290
1663
2.19
23.01
2.2
2.1
144.3
219.2
u/l
1.10
273
1567
456
3432
1.80
13.99
5.0
4.7
6.3
6.6
mmol/l
1.79
420
3153
381
2771
1.74
12.68
6.4
6.6
1.2
1.2
mmol/l
0.56
327
2356
561
4615
1.79
11.49
4.3
3.9
10.6
10.8
mm/h
0.17
527
4273
346
2526
1.67
10.79
5.7
5.9
1.2
1.2
mmol/l
1.50
316
2306
562
4671
1.75
10.58
7.2
6.9
76.6
77.6
u/l
0.23
538
4384
168
1033
1.80
9.58
4.2
3.5
265.1
318.5
ng/l
0.13
112
704
706
6384
2.26
9.30
15.8
13.1
139.7
139.7
mmol/l
0.00
698
6199
321
2369
1.61
9.15
4.2
4.5
36.3
36.2
g/l
0.18
308
2222
707
6405
2.25
9.12
15.9
13.2
3.9
3.9
mmol/l
0.36
695
6206
393
3080
1.56
8.43
5.5
5.9
12.8
10.7
umol/l
0.54
362
2909
38
135
2.91
8.22
1.0
1.5
515.8
128.8
e6/l
0.59
29
109
38
135
2.91
8.22
1.0
1.4
5.2
11.8
e6/l
0.43
27
105
703
6401
2.11
8.19
15.0
11.9
20.0
21.4
mg/l
0.61
567
4972
254
1833
1.58
7.65
2.5
2.4
57.2
55.6
u/l
0.34
238
1705
447
3667
1.52
7.37
8.9
8.7
3.9
4.0
e9/l
0.62
390
3233
662
5955
1.79
7.34
6.0
4.8
1.8
2.0
mu/l
0.47
619
5523
275
2042
1.54
7.21
3.2
3.2
63.8
54.4
ng/l
0.09
151
1231
204
1422
1.59
7.04
1.8
1.7
1.7
1.0
mg/l
0.51
143
1079
80
427
1.97
6.99
3.0
3.4
4.5
4.6
pmol/l
0.57
70
377
581
5076
1.59
6.96
5.1
4.1
14.6
14.6
pmol/l
0.24
542
4670
69
353
2.05
6.78
2.7
2.8
98.8
159.1
ng/l
1.55
63
318
277
2098
1.50
6.46
3.4
3.1
31.5
30.5
u/l
0.23
259
2009
292
2253
1.48
6.14
1.9
1.9
99.4
96.2
pmol/l
0.57
150
1170
213
1546
1.52
6.02
1.7
1.6
—
—
—
0
0
98
595
1.74
5.71
1.7
1.7
—
—
—
0
0
225
1668
1.49
5.70
1.3
1.3
0.7
1.9
u/ml
2.06
54
462
17
47
3.68
5.50
1.0
1.0
—
—
—
0
0
202
1483
1.49
5.32
2.1
2.1
2.4
2.9
mg/l
4.13
176
1279
723
6806
2.00
5.28
11.2
9.3
26.1
26.0
u/l
0.06
699
6579
162
1142
1.53
5.16
1.3
1.3
20.2
29.5
iu/ml
1.08
54
378
129
866
1.59
5.10
1.7
1.8
—
—
—
0
0
96
603
1.68
4.94
1.7
1.8
—
—
—
0
0
101
643
1.66
4.94
7.8
7.1
104.1
104.1
mmol/l
0.05
95
630
189
1388
1.48
4.93
3.4
3.6
1.0
1.0
kg/l
0.52
28
185
90
556
1.70
4.93
7.2
9.1
12.3
12.5
kpa
0.22
84
538
90
556
1.70
4.93
7.3
9.1
5.1
5.2
kpa
0.09
84
536
176
1276
1.49
4.89
1.4
1.5
21.4
21.3
nmol/l
0.02
156
1100
131
892
1.56
4.86
2.6
3.7
0.8
0.8
mmol/l
0.30
118
840
89
551
1.70
4.84
7.3
9.2
1.2
1.2
mmol/l
0.06
71
445
612
5565
1.48
4.65
17.7
14.5
13.4
13.5
%
0.97
602
5462
11
25
4.45
4.57
1.0
1.0
854.0
607.4
ng/l
—
6
15
11
25
4.45
4.57
1.0
1.0
225.3
315.7
ng/l
—
6
15
11
25
4.45
4.57
1.0
1.0
23.8
46.2
ng/l
—
6
14
372
3119
1.37
4.49
3.4
3.4
0.0
0.0
estimate
0.00
60
604
258
2053
1.39
4.24
3.1
3.0
—
—
—
0
0
16
51
3.18
4.22
1.0
1.1
196.2
232.4
mg/l
0.88
16
42
650
6015
1.51
4.22
4.1
4.0
5.8
5.8
mmol/l
0.14
602
5526
371
3133
1.35
4.17
4.9
4.6
0.0
0.0
estimate
0.50
63
612
246
1954
1.38
4.05
2.8
3.2
2.3
2.4
mmol/l
1.25
216
1728
89
578
1.61
4.03
3.1
2.3
31.4
118.0
u/l
0.52
77
482
358
3018
1.35
4.02
2.7
2.8
89.0
92.5
ug/l
0.16
337
2819
179
1349
1.43
4.00
2.5
3.0
947.8
880.2
ng/l
0.11
140
1112
151
1107
1.45
3.91
1.3
1.3
9.1
10.3
u/ml
0.07
64
438
102
690
1.55
3.89
2.3
2.0
—
—
—
0
0
156
1155
1.44
3.83
1.7
1.6
434.7
27500434.7
pmol/l
1.31
134
1000
39
706
0.53
3.78
1.6
1.6
—
—
—
0
0
371
3169
1.33
3.72
3.5
3.4
0.0
0.0
estimate
0.80
63
597
16
56
2.90
3.64
1.1
1.1
14.9
6.4
iu/ml
—
8
11
18
68
2.69
3.58
1.0
1.1
—
—
—
0
0
42
232
1.86
3.40
1.5
1.3
—
—
—
0
0
129
943
1.44
3.38
2.8
2.5
1.2
1.0
e6/l
0.17
71
520
83
555
1.56
3.35
1.9
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
132
2.08
3.10
3.1
3.0
0.4
0.3
u/ml
0.23
17
70
32
172
1.90
2.85
1.8
1.9
4.7
5.0
iu/l
0.05
15
61
81
561
1.50
2.80
1.2
1.2
121.5
158.6
iu/ml
0.42
35
237
128
969
1.38
2.75
2.7
2.6
2.4
2.4
mmol/l
0.38
114
847
46
280
1.68
2.74
1.7
1.7
—
—
—
0
0
523
4790
1.29
2.69
3.8
3.4
—
—
—
0
0
69
467
1.52
2.67
7.4
8.0
1.5
1.3
mmol/l
0.45
62
447
93
670
1.44
2.65
5.5
6.0
—
—
—
0
0
93
671
1.44
2.63
2.8
2.8
10.5
6.5
umol/l
0.30
79
574
56
364
1.58
2.59
1.9
2.3
12.3
12.6
nmol/l
0.08
48
333
600
5606
1.32
2.58
5.2
5.1
38.8
38.9
mmol/mol
0.06
566
5253
12
44
2.75
2.55
1.0
1.1
1.2
1.1
u/l
—
6
24
15
62
2.45
2.55
1.0
1.0
—
—
—
0
0
485
4415
1.27
2.55
3.1
3.0
46.3
43.1
u/l
0.22
451
4178
35
202
1.77
2.52
1.2
1.1
3.9
7.1
u/ml
—
5
34
645
6097
1.35
2.51
16.9
12.8
40.1
40.1
%
0.10
476
4742
34
195
1.78
2.51
1.5
1.3
—
—
—
0
0
71
495
1.48
2.40
4.0
4.0
6.0
5.8
kpa
0.76
63
480
61
412
1.52
2.40
1.0
1.0
—
—
—
0
0
70
490
1.47
2.33
4.0
4.1
2.2
1.9
mmol/l
0.32
52
385
15
65
2.33
2.32
1.0
1.1
—
—
—
0
0
71
500
1.46
2.29
2.2
2.5
0.2
0.2
g/l
0.62
66
476
284
2454
1.25
2.28
3.4
3.5
—
—
—
0
0
33
194
1.73
2.26
1.4
1.1
—
—
—
0
0
61
418
1.50
2.26
3.8
3.4
4.7
4.6
kpa
0.04
55
405
332
2922
1.24
2.25
3.7
3.9
—
—
—
0
0
20
100
2.03
2.22
2.9
2.0
13.1
13.2
%
0.07
20
100
22
115
1.94
2.17
1.8
3.2
31.9
34.7
umol/l
0.22
17
97
41
260
1.61
2.14
8.3
11.2
24.9
24.3
mmol/l
0.73
36
248
115
892
1.34
2.13
3.0
2.6
2.8
3.1
e6/l
0.20
57
471
112
872
1.33
2.03
1.8
1.8
1.5
1.4
%
0.31
97
795
5
11
4.57
1.94
1.0
1.5
—
—
—
0
0
193
1623
1.25
1.94
1.7
1.7
1.4
1.4
mmol/l
0.14
169
1393
190
1595
1.25
1.93
3.2
2.9
0.2
0.4
e6/l
0.87
135
1193
64
458
1.43
1.93
3.0
2.4
79.8
71.8
ml/min/173m2
0.83
28
189
0
54
0.00
1.85
0.0
2.2
—
2.2
—
0
28
6
17
3.55
1.84
1.2
1.3
—
—
—
0
0
12
53
2.28
1.81
1.2
1.2
1.6
0.1
u/ml
—
6
20
20
109
1.86
1.78
1.2
1.1
—
—
—
0
0
55
390
1.44
1.76
1.6
1.6
—
—
—
0
0
6
18
3.35
1.75
5.2
6.2
—
—
—
0
0
115
920
1.29
1.73
1.9
1.7
1158.5
1198.4
nmol/l
0.21
89
703
108
857
1.30
1.73
1.8
2.3
13.6
13.5
umol/l
0.02
101
787
79
607
1.34
1.60
1.8
2.1
379.3
372.6
nmol/l
0.13
67
569
293
2618
1.19
1.57
2.2
2.3
73.4
75.5
nmol/l
0.76
274
2378
19
107
1.80
1.56
1.7
1.4
—
—
—
0
0
171
1455
1.23
1.53
2.3
2.6
7440.7
6029.1
umol/l
0.13
146
1279
18
101
1.80
1.50
1.2
1.1
—
—
—
0
0
78
610
1.31
1.41
26.5
18.0
1.1
1.2
inr
0.50
16
90
9
41
2.21
1.37
1.3
1.6
—
—
—
0
0
34
232
1.49
1.36
1.9
1.8
—
—
—
0
0
0
39
0.00
1.34
0.0
1.5
—
1.3
—
0
18
9
42
2.16
1.34
1.0
1.5
—
—
—
0
0
16
90
1.79
1.34
1.9
1.3
—
—
—
0
0
0
40
0.00
1.33
0.0
1.8
—
1.4
—
0
31
54
407
1.35
1.27
2.1
2.2
6747.4
3822.5
u/l
0.25
21
167
138
1173
1.21
1.25
2.4
2.2
—
—
—
0
0
6
25
2.41
1.24
1.2
1.2
—
—
—
0
0
13
70
1.87
1.24
1.2
1.2
—
—
—
0
0
127
1073
1.22
1.23
2.4
2.1
—
—
—
0
0
11
57
1.94
1.17
1.3
1.6
61.7
57.5
%
—
6
41
27
182
1.50
1.17
4.2
2.8
3260.0
875.4
u/ml
0.33
27
157
650
6290
1.21
1.16
4.8
4.4
2.9
2.8
mmol/l
0.26
599
5858
13
72
1.82
1.15
1.0
1.5
—
—
—
0
0
20
126
1.60
1.15
1.2
1.5
108.5
110.8
u/ml
—
8
28
0
36
0.00
1.14
0.0
1.1
—
82.4
—
0
26
0
36
0.00
1.14
0.0
1.1
—
27.5
—
0
26
198
1755
1.17
1.13
3.8
3.1
7.5
7.6
mmol/l
0.19
170
1497
7
30
2.35
1.12
1.0
1.1
—
—
—
0
0
38
277
1.39
1.12
5.2
4.6
24.5
24.0
mmol/l
0.31
32
257
24
160
1.52
1.10
1.5
1.4
—
—
—
0
0
17
104
1.65
1.10
1.3
1.2
1.8
6.0
u/ml
—
8
48
52
400
1.32
1.10
1.2
1.5
53.3
25.0
iu/l
1.63
37
343
53
409
1.32
1.09
2.5
2.2
5.5
7.3
ug/l
0.62
43
369
8
41
1.96
1.09
1.0
1.3
—
28.3
—
0
6
56
437
1.30
1.07
2.0
3.6
1.2
1.2
mmol/l
0.21
50
378
640
6198
1.19
1.06
4.3
4.0
4.8
4.7
mmol/l
0.16
589
5808
24
162
1.50
1.05
1.4
1.4
291.0
315.7
ug/g
0.17
12
92
15
90
1.68
1.04
1.0
1.5
—
—
—
0
0
54
423
1.30
1.02
1.2
1.3
101.4
29.0
au/ml
—
5
24
122
1052
1.19
0.97
5.0
4.2
2.6
2.3
ug/l
0.14
108
952
16
100
1.61
0.97
1.0
1.5
—
—
—
0
0
178
1585
1.16
0.96
3.9
4.0
7.1
9.3
mg/mmol
0.32
105
994
39
295
1.34
0.94
1.5
1.3
249.0
250.8
miu/ml
0.01
23
150
10
55
1.83
0.92
1.1
1.4
—
—
—
0
0
98
833
1.20
0.92
4.7
3.9
23.2
21.3
%
0.45
41
357
19
126
1.52
0.92
3.2
3.9
53.8
56.7
%
0.32
19
126
93
787
1.21
0.92
1.8
2.3
2.4
2.4
g/l
0.16
84
728
8
42
1.91
0.88
1.0
1.4
—
290.0
—
0
5
75
628
1.22
0.83
3.3
2.7
0.7
0.8
ug/l
0.42
52
366
16
105
1.53
0.82
1.3
1.2
1.3
4.3
u/ml
—
6
38
8
47
1.71
0.81
1.4
1.1
—
—
—
0
0
36
277
1.31
0.80
2.2
1.7
—
—
—
0
0
9
148
0.60
0.79
1.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
8.4
—
0
24
184
1667
1.14
0.79
3.7
3.7
0.0
0.0
estimate
1.08
64
606
27
200
1.36
0.77
1.3
1.6
0.0
0.1
iu/ml
—
6
31
23
167
1.39
0.74
1.2
1.1
1.3
2.6
u/ml
—
6
69
15
100
1.51
0.73
1.3
1.3
—
—
—
0
0
7
39
1.80
0.72
1.0
1.4
—
18.9
—
0
9
21
151
1.40
0.72
1.1
1.6
—
—
—
0
0
134
1202
1.14
0.67
2.3
2.4
5.7
7.3
e6/l
0.80
122
1057
20
145
1.39
0.66
1.1
1.6
—
—
—
0
0
609
5939
1.12
0.63
3.7
3.6
1.3
1.3
mmol/l
0.15
563
5526
26
199
1.32
0.63
1.8
1.8
—
—
—
0
0
13
88
1.49
0.61
1.3
1.4
0.5
0.5
nmol/l
0.22
13
81
0
20
0.00
0.60
0.0
2.2
—
74.5
—
0
20
0
22
0.00
0.59
0.0
1.2
—
337.6
—
0
15
16
114
1.41
0.59
1.1
1.0
2.2
2.0
u/ml
—
10
55
609
5947
1.11
0.59
12.7
10.7
89.0
87.1
ml/min/173m2
1.31
514
4809
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
13
89
1.47
0.58
1.2
1.1
—
—
—
0
0
6
35
1.72
0.57
1.0
1.2
—
—
—
0
0
156
1429
1.11
0.57
2.2
2.1
—
—
—
0
0
148
1354
1.12
0.56
1.5
1.4
—
—
—
0
0
61
706
0.85
0.56
4.7
4.0
30.7
31.8
%
0.45
39
475
631
6182
1.11
0.54
4.3
4.0
1.5
1.5
mmol/l
0.33
588
5768
17
125
1.37
0.54
1.3
1.4
19.5
20.7
u/l
0.07
17
109
17
125
1.37
0.54
1.5
1.6
6924.8
16080.1
e6/l
0.85
12
89
19
143
1.34
0.53
1.2
1.3
—
—
—
0
0
33
270
1.23
0.50
1.4
1.4
—
—
—
0
0
6
41
1.47
0.50
1.0
1.0
—
—
—
0
0
27
216
1.26
0.50
1.8
2.0
—
—
—
0
0
45
528
0.84
0.49
1.5
1.5
—
—
—
0
0
7
45
1.56
0.49
1.3
1.4
—
—
—
0
0
7
45
1.56
0.49
2.7
3.3
—
—
—
0
0
18
137
1.32
0.47
1.2
1.4
222.5
230.3
u/ml
—
10
83
22
274
0.80
0.44
1.7
1.4
—
—
—
0
0
25
202
1.25
0.44
1.2
1.2
—
—
—
0
0
25
202
1.25
0.44
1.2
1.2
—
—
—
0
0
6
91
0.66
0.42
7.5
4.1
31.7
441.5
u/ml
—
6
86
5
32
1.57
0.42
1.2
2.9
723.4
733.1
u/ml
—
5
32
8
58
1.38
0.41
3.5
3.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
20
159
1.26
0.40
3.8
4.1
3.8
3.9
mmol/l
0.09
20
146
30
357
0.83
0.40
1.5
1.4
—
—
—
0
0
5
34
1.47
0.40
1.0
1.0
—
—
—
0
0
28
232
1.21
0.40
1.3
1.6
30.4
10.0
u/l
0.65
21
198
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
7
106
0.66
0.39
1.0
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
55
488
1.14
0.37
4.1
4.1
10.9
16.9
ug/l
0.21
42
396
17
135
1.27
0.35
3.2
2.2
0.0
0.0
g/l
0.00
17
127
6
44
1.37
0.34
1.3
1.6
—
—
—
0
0
23
275
0.83
0.34
1.7
1.4
—
—
—
0
0
23
275
0.83
0.34
1.7
1.4
—
—
—
0
0
13
100
1.31
0.33
1.0
1.1
123.9
116.8
%
0.49
13
91
14
109
1.29
0.33
1.0
1.1
—
—
—
0
0
16
199
0.80
0.33
1.4
1.5
—
—
—
0
0
23
274
0.83
0.33
1.7
1.4
—
—
—
0
0
17
137
1.25
0.32
3.2
2.2
0.0
0.0
g/l
0.00
17
128
17
137
1.25
0.32
1.2
2.3
0.7
0.8
nmol/l
0.18
11
118
27
316
0.85
0.32
1.7
1.8
2.6
3.0
mg/l
0.11
16
226
18
147
1.23
0.31
3.1
2.6
—
—
—
0
0
26
222
1.18
0.29
1.8
1.9
—
—
—
0
0
22
185
1.19
0.29
3.8
4.2
1.3
1.3
mmol/l
0.07
22
180
13
104
1.25
0.26
4.0
2.5
17.3
16.6
%
—
6
60
19
160
1.19
0.25
3.0
2.3
0.9
1.0
g/l
0.07
19
144
9
77
1.17
0.24
1.2
1.1
—
—
—
0
0
20
232
0.86
0.23
1.6
1.7
—
—
—
0
0
5
40
1.25
0.22
1.4
1.2
35.8
33.0
nmol/l
—
5
32
17
144
1.18
0.22
3.2
2.2
0.0
0.0
g/l
0.01
17
135
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
43.6
—
0
10
0
10
0.00
0.21
0.0
1.0
—
8.2
—
0
10
0
10
0.00
0.21
0.0
2.7
—
0.6
—
0
10
77
723
1.07
0.20
1.9
2.4
19.1
23.0
%
2.01
66
623
21
183
1.15
0.20
2.9
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
0.1
—
0
8
9
111
0.81
0.20
1.9
1.8
—
—
—
0
0
7
59
1.19
0.18
1.4
1.8
—
—
—
0
0
17
148
1.15
0.17
3.2
2.1
37.3
38.7
g/l
0.58
17
133
5
70
0.71
0.16
1.0
1.5
—
—
—
0
0
60
564
1.07
0.16
3.0
3.0
—
—
—
0
0
27
297
0.91
0.15
1.6
1.5
—
—
—
0
0
7
88
0.79
0.14
1.1
1.5
—
—
—
0
0
36
334
1.08
0.14
1.6
1.4
—
—
—
0
0
14
122
1.15
0.14
2.4
1.7
—
—
—
0
0
16
143
1.12
0.11
1.8
1.6
0.4
0.3
nmol/l
—
9
116
19
172
1.11
0.11
3.0
2.2
10.7
10.7
g/l
0.02
19
151
12
136
0.88
0.11
3.4
3.5
—
2.1
—
0
16
30
282
1.07
0.09
1.8
1.9
—
—
—
0
0
6
55
1.09
0.09
1.2
1.6
—
—
—
0
0
6
55
1.09
0.09
1.3
1.2
—
—
—
0
0
6
55
1.09
0.09
1.3
1.2
—
—
—
0
0
6
55
1.09
0.09
1.2
1.6
—
—
—
0
0
6
55
1.09
0.09
1.2
1.6
—
—
—
0
0
6
56
1.07
0.08
1.3
1.2
—
—
—
0
0
6
56
1.07
0.08
1.3
1.2
—
—
—
0
0
6
56
1.07
0.08
1.3
1.2
—
—
—
0
0
38
361
1.06
0.08
4.3
3.9
1.2
1.6
mmol/l
0.25
31
268
6
58
1.03
0.08
1.0
1.3
—
—
—
0
0
7
65
1.08
0.08
1.1
1.6
—
—
—
0
0
8
78
1.03
0.07
1.0
1.5
—
—
—
0
0
7
82
0.85
0.07
1.0
1.4
—
—
—
0
0
7
82
0.85
0.07
1.0
1.4
—
—
—
0
0
7
83
0.84
0.07
1.0
1.4
—
—
—
0
0
7
83
0.84
0.07
1.0
1.4
—
—
—
0
0
7
84
0.83
0.07
1.0
1.4
—
—
—
0
0
7
84
0.83
0.07
1.0
1.4
—
—
—
0
0
13
118
1.10
0.07
1.4
1.1
—
—
—
0
0
45
433
1.04
0.06
1.4
1.3
—
—
—
0
0
13
119
1.09
0.06
1.5
1.2
—
—
—
0
0
20
188
1.07
0.05
1.7
1.4
99.4
166.5
pmol/l
0.40
20
183
20
190
1.05
0.04
1.3
1.2
4.0
10.8
u/ml
—
6
34
10
92
1.09
0.03
1.2
1.2
—
—
—
0
0
11
116
0.95
0.00
1.4
1.3
—
—
—
0
0
11
116
0.95
0.00
1.4
1.3
—
—
—
0
0
15
146
1.03
0.00
1.3
1.3
—
—
—
0
0
26
264
0.98
0.00
1.4
1.6
—
—
—
0
0
16
158
1.01
0.00
1.5
1.3
—
—
—
0
0
13
131
0.99
0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
12
120
1.00
0.00
1.9
2.4
16.6
139.4
ug/min
—
7
73
27
270
1.00
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
13
130
1.00
0.00
1.8
1.6
—
—
—
0
0
6
59
1.02
0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.2
1.2
2.0
1.4
nmol/l
—
6
54
5
51
0.98
0.00
1.2
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
8
87
0.92
0.00
1.1
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_ANOMAPUPFUNC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.182 [0.96, 1.46] | 0.124 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 169 out of 2968 females with H7_ANOMAPUPFUNC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.53 [1.15, 2.03] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 1746 males with H7_ANOMAPUPFUNC died.
Mortality risk
Mortality risk for people of age
years, who have H7_ANOMAPUPFUNC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.289% |
| 5 | 0.718% | 1.814% |
| 10 | 1.711% | 4.479% |
| 15 | 3.221% | 8.656% |
| 20 | 5.523% | 14.409% |
Relationships between endpoints
↥Index endpoint: H7_ANOMAPUPFUNC – Anomalies of pupillary function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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