No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1209 |
4. Check minimum number of eventsNone |
1209 |
5. Include endpointsNone |
1209 |
6. Filter based on genotype QC (FinnGen only) |
1164 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
- Name in latin
- Degeneratio peripherica retinae
Similar endpoints
↥List of similar endpoints to
Peripheral retinal degeneration
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8552 | 5217 | 3289 |
| Only index persons | 7974 | 4943 | 3031 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.15 | 0.09 |
| Only index persons | 0.16 | 0.18 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 54.77 | 54.91 | 54.52 |
| Only index persons | 53.95 | 54.19 | 53.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1164 | 722 | 442 |
| Unadjusted period prevalence (%) | 0.24 | 0.26 | 0.20 |
| Median age at first event (years) | 54.65 | 52.89 | 57.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1209
- Matched controls
- 12090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H33.3
ICD-10 Finland
Retinal breaks without detachment
1894.5
311.3
289
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
4503599627370496.0
307.7
1146
*
CKC12
NOMESCO Finland
Photocoagulation of retina
516.5
307.7
432
13
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2500.0
234.1
219
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
1274.6
223.2
211
*
WX140
NOMESCO Finland
Parabulbar anesthesy
17.3
143.9
122
78
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
46.3
125.2
74
17
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.3
120.4
229
431
H52.1
ICD-10 Finland
Myopia
10.2
117.4
139
152
H43.8
ICD-10 Finland
Other disorders of vitreous body
5.5
111.6
249
542
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
42.0
99.2
60
15
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
18.1
95.2
78
46
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.8
86.3
174
342
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.1
74.8
245
712
H43.1
ICD-10 Finland
Vitreous haemorrhage
18.2
72.6
59
34
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
236.2
65.9
67
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
81.4
61.7
69
9
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
80.1
60.7
68
9
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.6
58.8
154
375
H26.4
ICD-10 Finland
After-cataract
4.1
56.9
174
476
CKD40
NOMESCO Finland
Endophotocoagulation of retina
573.6
56.1
55
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
573.6
56.1
55
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.6
53.7
505
2637
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
101.5
53.3
58
6
H26.2
ICD-10 Finland
Complicated cataract
17.4
50.7
42
25
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
46.1
44
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.5
45.1
418
2133
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
43.5
610
3712
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
40.6
255
1073
3626A
ICD-9 Finland
Other retinal disorders, Peripheral retinal degenerations
+∞
39.8
38
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
39.8
38
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
39.8
38
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.6
36.8
90
206
H26.02
ICD-10 Finland
Presenil cataract
6.1
36.5
65
112
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
33.5
32
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
31.2
339
1807
S01ED51
ATC
timolol, combinations; ophthalmic
3.4
30.6
117
368
XCK10
NOMESCO Finland
Photography of fundus of eye
3.2
30.3
126
418
XCD10
NOMESCO Finland
Electrophysiological examination of eye
5.9
28.4
52
92
37711
ICD-8 Finland
Other diseases of retina and optic nerve, Degeneratio retinae
+∞
28.2
27
*
H53.1
ICD-10 Finland
Subjective visual disturbances
3.3
28.1
114
372
H33.5
ICD-10 Finland
Other retinal detachments
37.6
26.2
33
9
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
26.1
25
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
26.1
25
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
74.4
25.9
29
*
ZXA10
NOMESCO Finland
Bilateral
2.2
25.4
246
1240
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
51.2
25.3
30
6
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
92.0
24.7
27
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
26.0
24.0
33
13
XCK00
NOMESCO Finland
Perimetry
3.3
23.7
91
287
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
21.9
21
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
223.9
21.7
22
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
+∞
20.9
20
*
3745
FHL
Hard membrane girding, cerclage with coagulation
213.5
20.6
21
*
H44.2
ICD-10 Finland
Degenerative myopia
112.0
20.6
22
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
19.8
19
*
XCD20
NOMESCO Finland
Photoangiography of eye
34.9
18.9
24
7
XCH00
NOMESCO Finland
Eye pressure measurement
3.6
18.4
63
184
H40.0
ICD-10 Finland
Glaucoma suspect
2.6
17.8
108
438
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.4
17.8
26
36
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
17.7
17
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
182.6
17.6
18
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
17.4
114
481
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
16.7
16
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
162.0
15.5
16
*
H35.37
ICD-10 Finland
Macular holes
162.0
15.5
16
*
S01BC05
ATC
ketorolac; ophthalmic
3.4
15.3
56
171
H33
ICD-10 Finland
Retinal detachments and breaks
45.6
15.1
18
*
S01ED01
ATC
timolol; ophthalmic
3.7
14.9
48
135
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
14.6
14
*
H53.4
ICD-10 Finland
Visual field defects
4.3
14.2
36
85
H43.3
ICD-10 Finland
Other vitreous opacities
5.2
14.1
29
57
H34.8
ICD-10 Finland
Other retinal vascular occlusions
43.0
14.1
17
*
S01EC01
ATC
acetazolamide; systemic
4.9
14.1
31
65
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
13.6
13
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
13.6
13
*
S01EA03
ATC
apraclonidine; ophthalmic
12.3
13.1
23
19
S01EC03
ATC
dorzolamide; ophthalmic
5.8
12.8
23
40
S01BC03
ATC
diclofenac; ophthalmic
4.2
12.6
33
80
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.1
12.2
52
175
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
11.9
141
756
WX142
NOMESCO Finland
Sub-tenon anesthesy
23.1
11.6
16
7
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
11.5
11
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
121.1
11.4
12
*
S01EE01
ATC
latanoprost; ophthalmic
2.5
11.0
72
303
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
43.7
10.9
13
*
ZXA05
NOMESCO Finland
Left side
1.6
10.8
279
1880
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.7
10.5
57
219
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
11.4
10.1
18
16
ZXA00
NOMESCO Finland
Right side
1.6
10.0
300
2091
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.8
9.5
28
74
H35.36
ICD-10 Finland
Macular cyst
100.8
9.4
10
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
9.4
9
*
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
9.4
9
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
9.0
71
325
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.9
8.9
124
700
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
12.6
8.9
15
12
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
8.4
85
431
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
8.3
8
*
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
+∞
8.3
8
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.7
8.3
44
168
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
8.2
194
1271
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.1
7.9
32
105
XCW10
NOMESCO Finland
Assessment of vision
6.0
7.7
20
34
S01FA01
ATC
atropine; ophthalmic
11.9
7.6
13
11
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
3.5
7.4
25
73
F05
ICPC
Visual disturbance other
2.7
7.4
38
143
H25.8
ICD-10 Finland
Other senile cataract
1.8
7.3
102
577
3619X
ICD-9 Finland
Retinal detachments and defects, Unspecified retinal detachment
+∞
7.3
7
*
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
7.3
7
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
7.3
7
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
+∞
7.3
7
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
15.8
7.2
11
7
A98
ICPC
Health maint/preventive medicine
2.0
7.2
1147
10885
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
2.9
6.9
31
108
S01BA04
ATC
prednisolone; ophthalmic
3.0
6.8
29
98
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
6.1
6.8
17
28
F29
ICPC
Eye symptom/complaint other
1.8
6.6
103
603
R01AD09
ATC
mometasone; nasal
1.4
6.5
496
4072
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
70.2
6.4
7
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
14.4
6.4
10
7
S01EC04
ATC
brinzolamide; ophthalmic
2.3
6.3
44
192
SPAT1263
SPAT
Sampling
1.4
6.3
439
3544
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
6.3
212
1502
114
Kela drug reimbursment
Glaucoma
1.8
6.2
84
470
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.1
235
1709
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
613
4767
1.58
13.48
5.2
4.9
0.00
0.00
estimate
0.50
128
889
612
4759
1.58
13.45
3.9
3.6
0.01
0.00
estimate
0.23
136
947
611
4816
1.54
12.19
3.9
3.6
0.00
0.01
estimate
0.80
126
865
485
3699
1.52
10.87
4.0
3.8
—
—
—
0
0
588
4803
1.44
8.66
6.3
6.4
1.22
1.21
mmol/l
1.20
487
4075
132
793
1.75
7.72
3.4
3.8
1.23
1.23
mmol/l
0.14
115
692
503
4055
1.41
7.67
2.4
2.2
80.55
77.21
nmol/l
1.75
463
3643
334
2538
1.44
6.96
4.3
3.9
0.00
0.00
estimate
0.69
126
861
1157
11042
2.11
6.70
21.3
20.2
39.95
40.06
%
0.20
1074
10333
1157
11047
2.10
6.61
21.5
20.1
250.55
252.35
e9/l
0.42
1136
10768
1157
11051
2.09
6.54
21.5
20.1
6.62
6.65
e9/l
0.19
1134
10749
1092
10252
1.67
6.54
15.9
15.5
139.77
139.70
mmol/l
0.46
1071
9986
1157
11053
2.09
6.50
21.5
20.1
4.49
4.48
e12/l
0.46
1135
10752
1157
11056
2.08
6.45
21.6
20.2
135.55
134.99
g/l
0.73
1146
10890
1094
10286
1.67
6.38
16.1
15.6
3.96
3.97
mmol/l
0.11
1072
10008
826
7361
1.39
6.32
4.3
4.0
10.45
12.09
mm/h
3.26
769
6825
856
7684
1.39
6.20
4.4
4.0
14.88
14.72
pmol/l
1.19
780
7042
1117
10596
1.71
5.82
10.5
10.1
25.14
26.04
u/l
1.06
1079
10247
447
3720
1.32
4.97
3.8
3.5
44.21
49.38
ng/l
0.12
294
2495
983
9172
1.38
4.60
5.1
4.7
1.87
2.05
mu/l
0.73
914
8438
259
2011
1.37
4.54
2.4
2.5
4.77
6.39
e6/l
1.00
233
1831
375
3082
1.31
4.46
2.6
2.5
61.39
85.83
u/l
0.44
348
2851
353
2878
1.32
4.45
3.2
3.2
32.81
77.56
e6/l
1.05
286
2241
162
1165
1.45
4.41
2.0
2.2
124.41
124.03
ug/g
0.00
131
935
327
2654
1.32
4.22
3.0
3.1
0.23
0.46
e6/l
2.73
267
2041
692
6202
1.27
4.04
3.2
2.9
—
—
—
0
0
87
562
1.59
3.93
3.1
2.8
134.54
128.12
g/l
1.90
82
551
257
2039
1.33
3.86
1.6
1.7
430.85
26529840.60
pmol/l
2.01
223
1700
977
9188
1.33
3.71
5.8
5.3
39.14
39.38
mmol/mol
0.38
910
8546
1043
9913
1.38
3.64
14.6
13.7
21.67
23.43
mg/l
0.92
847
7805
263
2115
1.31
3.57
1.3
1.2
0.66
1.54
u/ml
2.76
79
584
708
6420
1.25
3.50
4.4
4.3
67.00
2358.40
e6/l
1.47
12
90
922
8627
1.29
3.46
18.0
16.4
14.42
14.92
%
2.34
910
8472
222
1752
1.33
3.44
1.2
1.3
45.73
33.39
iu/ml
0.33
64
581
336
2814
1.27
3.31
5.0
4.7
2.04
2.68
ug/l
1.10
303
2525
326
2728
1.27
3.22
2.8
2.9
1108.35
1223.73
ng/l
0.21
288
2311
630
5693
1.22
3.02
4.4
4.6
6.69
6.60
mmol/l
0.43
596
5345
256
2100
1.28
2.96
4.2
3.9
1.01
1.02
kg/l
1.48
34
300
205
1638
1.30
2.90
1.4
1.5
—
—
—
0
0
58
370
1.60
2.83
1.3
1.3
0.87
1.04
u/ml
—
9
33
133
1005
1.36
2.76
3.5
3.3
—
—
—
0
0
821
7662
1.22
2.71
7.3
7.4
75.31
78.17
u/l
1.22
781
7223
270
2256
1.25
2.66
4.3
4.1
22.14
21.22
%
0.51
137
1049
570
5151
1.20
2.58
5.5
6.2
11.80
11.34
umol/l
0.27
541
4918
5
7
7.17
2.55
1.2
1.0
—
—
—
0
0
1033
9910
1.29
2.54
4.5
4.3
4.67
4.73
mmol/l
0.95
962
9241
88
1204
0.71
2.50
4.5
4.3
32.22
32.14
%
0.03
69
827
11
37
2.99
2.49
8.3
4.5
—
—
—
0
0
490
4378
1.20
2.48
5.9
5.7
1.21
1.21
mmol/l
0.19
453
4006
624
5710
1.19
2.40
8.9
9.0
4.10
4.05
e9/l
0.22
571
5031
111
835
1.36
2.39
4.5
3.2
1.95
2.04
mmol/l
0.12
95
686
1015
9732
1.27
2.39
4.6
4.4
5.88
5.89
mmol/l
0.10
938
8930
14
58
2.43
2.37
2.7
2.3
—
—
—
0
0
383
3356
1.21
2.37
2.6
3.4
2.35
2.35
mmol/l
0.15
344
2983
43
270
1.61
2.28
1.4
1.3
—
—
—
0
0
1024
9855
1.26
2.16
4.5
4.3
1.51
1.48
mmol/l
1.37
951
9135
23
123
1.89
2.12
1.8
2.2
32.96
32.29
pg
0.37
23
123
466
4190
1.18
2.12
4.1
4.6
35.49
35.62
g/l
0.19
429
3908
41
260
1.60
2.11
1.1
1.1
—
—
—
0
0
1045
10087
1.27
2.10
5.0
4.8
2.75
2.80
mmol/l
1.24
977
9345
983
9427
1.23
2.09
13.1
12.6
79.89
81.24
ml/min/173m2
1.34
848
7809
471
4248
1.18
2.05
3.0
2.7
140.91
123.49
ug/l
0.52
434
3929
493
4469
1.17
2.01
16.4
14.3
1.23
1.24
inr
0.13
170
1292
991
9523
1.23
1.99
4.1
3.9
1.26
1.30
mmol/l
0.98
921
8770
336
2952
1.19
1.98
2.0
2.1
241.62
189.24
u/l
0.32
315
2787
80
591
1.38
1.97
3.0
3.3
4.47
4.54
pmol/l
0.26
72
519
219
1850
1.22
1.94
1.5
1.5
2.41
2.45
g/l
0.11
138
1141
45
302
1.51
1.85
2.1
1.8
—
—
—
0
0
8
29
2.77
1.79
2.3
2.9
—
—
—
0
0
8
29
2.77
1.79
1.8
1.9
—
—
—
0
0
8
29
2.77
1.79
2.3
2.9
—
—
—
0
0
201
1698
1.22
1.79
1.2
1.2
9.43
12.43
u/ml
0.28
83
668
63
456
1.40
1.77
1.9
1.8
—
—
—
0
0
39
575
0.67
1.72
1.8
1.6
—
—
—
0
0
194
1640
1.22
1.72
3.1
2.9
0.73
0.77
ug/l
0.28
129
1058
212
1808
1.21
1.72
2.3
2.9
2.45
2.45
mmol/l
0.02
187
1602
65
476
1.39
1.71
1.0
1.0
—
—
—
0
0
11
48
2.30
1.70
1.1
1.1
1.04
1.06
ratio
—
6
18
15
75
2.01
1.70
2.3
1.7
18.43
19.34
nmol/l
0.13
15
69
20
111
1.82
1.69
1.4
1.3
—
—
—
0
0
32
204
1.58
1.66
2.2
3.6
31.29
25.61
mg/l
0.33
21
129
80
610
1.33
1.65
2.3
2.1
11.37
12.36
nmol/l
0.47
69
543
5
14
3.58
1.61
1.6
1.4
—
—
—
0
0
25
151
1.67
1.60
1.6
1.6
—
—
—
0
0
7
156
0.45
1.55
2.9
1.7
—
—
—
0
0
7
156
0.45
1.55
2.9
1.7
—
—
—
0
0
511
4731
1.14
1.44
6.4
5.8
28.29
27.95
%
0.27
486
4449
504
4670
1.14
1.39
6.3
5.6
56.86
57.16
%
0.21
480
4385
288
2569
1.16
1.38
2.6
2.5
1714.85
6437.35
umol/l
2.23
254
2251
5
17
2.95
1.36
1.4
1.2
—
—
—
0
0
49
358
1.38
1.36
1.9
1.7
—
—
—
0
0
91
735
1.26
1.27
3.6
3.4
85.81
81.46
ng/l
0.29
78
643
79
629
1.27
1.24
1.3
1.2
64.45
212.24
u/ml
3.04
72
574
49
366
1.35
1.21
3.1
2.6
—
—
—
0
0
75
936
0.79
1.21
1.8
1.8
—
—
—
0
0
48
358
1.35
1.20
1.4
1.5
—
—
—
0
0
199
1750
1.16
1.16
1.7
1.7
1310.80
1198.25
nmol/l
0.85
159
1314
0
34
0.00
1.16
0.0
1.8
—
—
—
0
0
0
34
0.00
1.16
0.0
1.8
—
—
—
0
0
0
34
0.00
1.16
0.0
1.8
—
—
—
0
0
145
1246
1.19
1.12
6.1
5.1
1.00
1.02
mmol/l
0.46
134
1142
30
210
1.44
1.09
1.4
1.5
—
—
—
0
0
39
287
1.37
1.08
1.1
1.1
—
—
—
0
0
183
1610
1.16
1.07
2.9
2.7
0.81
1.06
e6/l
1.09
118
930
94
780
1.22
1.06
2.7
2.5
63.45
67.21
ml/min/173m2
0.49
40
322
39
289
1.36
1.04
1.1
1.1
—
—
—
0
0
9
48
1.88
1.00
1.1
1.2
—
—
—
0
0
11
188
0.58
0.99
1.3
1.6
—
—
—
0
0
9
51
1.77
0.94
1.6
1.3
—
1282.00
—
0
5
101
1185
0.84
0.94
1.7
1.8
1.58
1.47
%
0.39
93
1038
42
322
1.32
0.92
2.0
2.9
—
—
—
0
0
24
337
0.71
0.91
1.7
2.3
119.71
422.97
ug/l
2.38
24
316
11
63
1.75
0.90
1.2
1.3
—
—
—
0
0
177
1580
1.14
0.87
2.8
3.3
0.83
0.82
mmol/l
0.74
161
1482
29
389
0.74
0.85
1.8
1.8
2.92
4.76
mg/l
0.52
19
289
46
363
1.28
0.84
1.3
1.4
—
—
—
0
0
6
111
0.54
0.83
3.2
1.7
—
—
—
0
0
6
111
0.54
0.83
3.2
1.7
—
—
—
0
0
184
1654
1.13
0.82
1.4
1.4
—
—
—
0
0
28
375
0.74
0.82
4.5
3.8
24.88
25.15
mmol/l
0.26
28
351
16
105
1.53
0.82
1.9
1.7
—
—
—
0
0
10
58
1.73
0.79
1.5
1.8
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
195.34
—
0
18
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
14
90
1.56
0.78
1.4
2.1
3.19
5.30
umol/l
—
8
63
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
315
0.72
0.78
1.7
2.7
0.27
0.37
u/ml
0.86
12
176
58
476
1.23
0.77
1.4
1.3
24.49
32.50
iu/l
0.95
50
406
285
2637
1.11
0.77
1.7
1.6
1.30
1.38
mmol/l
1.00
224
2244
7
38
1.85
0.73
1.0
1.1
—
45.00
ng/l
—
0
6
80
683
1.18
0.72
2.7
2.4
34.90
22.28
au/ml
—
6
52
5
25
2.00
0.72
1.8
1.2
17.04
33.78
nmol/l
—
5
19
80
685
1.18
0.71
1.6
1.6
—
—
—
0
0
17
118
1.45
0.69
1.4
1.4
—
—
—
0
0
5
27
1.86
0.68
1.6
1.5
—
—
—
0
0
26
198
1.32
0.64
1.8
2.4
16.38
16.03
%
0.17
12
102
5
29
1.73
0.64
1.2
1.4
—
—
—
0
0
24
181
1.33
0.63
1.4
1.5
—
—
—
0
0
165
1502
1.11
0.62
3.2
2.9
3.14
2.63
e6/l
0.24
102
825
12
176
0.68
0.62
1.5
1.4
—
13.18
—
0
5
5
30
1.67
0.61
2.2
1.6
17.40
14.01
pmol/l
—
5
25
8
50
1.60
0.61
1.4
3.1
1502.25
1076.16
u/ml
—
8
50
37
299
1.24
0.60
1.4
1.5
0.94
0.25
iu/ml
0.36
11
56
65
558
1.17
0.58
1.6
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
7
114
0.61
0.58
1.6
2.4
—
26.08
—
0
28
6
35
1.72
0.57
1.2
2.4
16.67
16.98
ug/l
—
6
30
41
338
1.22
0.56
2.0
1.6
—
—
—
0
0
5
87
0.57
0.56
2.2
1.6
0.89
1.01
g/l
—
5
87
13
90
1.45
0.55
1.5
1.3
—
—
—
0
0
11
74
1.49
0.53
1.0
1.7
—
—
—
0
0
38
314
1.22
0.52
1.4
1.7
—
—
—
0
0
18
237
0.76
0.52
2.1
1.7
6309.92
14708.58
e6/l
1.36
12
174
684
6650
1.07
0.51
3.2
3.1
43.67
48.79
u/l
0.94
636
6232
6
41
1.47
0.50
1.2
1.1
—
11.33
u/ml
—
0
6
112
1013
1.12
0.50
2.8
4.0
38.59
16.03
ug/l
0.28
91
833
237
2224
1.08
0.49
2.0
1.7
1.21
1.12
mg/l
0.12
180
1699
10
144
0.69
0.49
6.9
5.9
318.20
373.92
umol/l
—
10
130
34
280
1.22
0.49
1.5
1.4
273.65
299.91
ug/g
0.32
23
161
33
271
1.22
0.49
1.4
1.8
—
—
—
0
0
47
400
1.18
0.49
1.1
1.0
—
1.05
—
0
6
410
3927
1.07
0.49
1.9
2.0
93.85
95.85
pmol/l
0.42
205
2038
11
76
1.45
0.48
1.5
2.0
—
—
—
0
0
220
2344
0.92
0.47
2.2
2.2
—
—
—
0
0
7
48
1.46
0.47
1.1
1.3
—
—
—
0
0
5
83
0.60
0.45
1.0
1.0
—
—
—
0
0
88
791
1.12
0.45
2.5
2.4
6.30
7.51
ug/l
0.29
82
692
35
293
1.20
0.44
3.6
4.0
45.26
72.66
mg/l
0.63
29
236
23
285
0.80
0.44
4.3
2.2
184.17
183.95
%
0.01
23
270
17
218
0.78
0.42
1.8
1.7
—
—
—
0
0
31
258
1.21
0.42
1.0
1.1
0.82
5.97
u/ml
—
5
32
50
435
1.16
0.42
2.6
1.9
45.22
38.85
u/l
1.65
45
394
101
1106
0.91
0.41
1.5
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
8
60
1.34
0.40
1.4
1.2
10.38
14.47
u/l
—
8
53
18
226
0.79
0.39
1.7
1.7
—
—
—
0
0
18
142
1.27
0.38
3.3
3.0
—
2091.77
—
0
13
9
66
1.37
0.38
1.8
1.4
73.67
77.05
umol/l
—
9
66
9
66
1.37
0.38
1.0
1.5
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
1641.40
1831.92
miu/ml
—
5
36
12
89
1.35
0.38
1.4
1.2
0.10
0.89
u/ml
—
7
44
27
225
1.20
0.37
2.1
1.5
—
—
—
0
0
14
107
1.31
0.37
1.9
1.8
—
—
—
0
0
18
143
1.26
0.37
1.3
1.2
3.50
2.43
u/ml
—
8
37
20
162
1.24
0.35
2.2
1.8
162.80
199.10
pmol/l
0.71
20
153
303
2907
1.06
0.35
3.5
3.5
6.11
7.78
mg/mmol
0.48
200
1811
12
91
1.32
0.34
1.3
1.5
—
—
—
0
0
27
228
1.19
0.33
2.5
1.5
1272.80
675.01
e6/l
0.25
20
189
6
46
1.31
0.33
4.5
1.4
—
—
—
0
0
6
46
1.31
0.33
4.5
1.4
—
—
—
0
0
34
294
1.16
0.32
3.7
4.0
34.88
44.60
mg/l
0.36
28
236
6
47
1.28
0.32
1.3
1.2
126.28
165.38
pmol/l
—
6
47
17
137
1.24
0.32
1.0
1.0
1.16
2.02
u/ml
—
8
58
16
128
1.25
0.32
1.4
1.5
—
—
—
0
0
157
1481
1.07
0.31
2.8
2.4
14.11
13.10
umol/l
1.08
144
1378
7
56
1.25
0.29
1.0
1.6
—
—
—
0
0
149
1575
0.94
0.29
1.7
1.9
—
—
—
0
0
7
57
1.23
0.29
1.0
1.6
—
—
—
0
0
120
1126
1.07
0.28
3.8
2.6
5.98
7.85
umol/l
1.69
98
980
15
184
0.81
0.28
2.0
1.6
—
—
—
0
0
31
354
0.87
0.28
1.8
1.8
—
—
—
0
0
104
1108
0.93
0.26
1.6
1.8
—
—
—
0
0
56
511
1.10
0.26
1.1
1.4
—
—
—
0
0
11
87
1.27
0.24
1.5
1.4
6.51
6.77
mmol/l
0.21
11
79
29
255
1.14
0.24
1.5
1.9
2961.20
3029.49
u/l
—
8
97
15
124
1.21
0.24
1.3
1.4
0.49
0.63
nmol/l
1.08
15
117
26
228
1.14
0.23
2.5
1.4
7.81
12.87
e6/l
0.35
16
183
125
1188
1.06
0.22
8.2
6.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
6.3
—
6.38
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
108
1024
1.06
0.21
3.3
2.5
1.78
1.81
%
0.11
97
912
12
145
0.83
0.21
1.0
1.5
—
—
—
0
0
24
272
0.88
0.21
1.5
1.3
—
—
—
0
0
27
303
0.89
0.20
3.9
2.0
94.85
91.01
%
0.35
27
293
10
123
0.81
0.20
1.5
1.5
—
—
—
0
0
6
48
1.25
0.20
3.3
4.1
—
—
—
0
0
89
840
1.06
0.20
2.8
6.7
1.31
1.37
mmol/l
0.35
84
818
98
928
1.06
0.20
1.9
2.2
0.21
0.21
g/l
0.38
92
863
16
136
1.18
0.20
1.8
1.7
—
—
—
0
0
9
111
0.81
0.20
1.2
1.1
93.78
95.45
%
—
9
104
35
385
0.91
0.19
2.0
1.9
—
—
—
0
0
10
81
1.24
0.18
1.8
1.2
—
—
—
0
0
7
60
1.17
0.17
1.4
1.4
12.86
13.09
u/l
—
7
55
338
3310
1.03
0.16
3.4
3.2
33.91
31.88
u/l
0.19
324
3157
30
273
1.10
0.16
1.6
1.5
—
—
—
0
0
8
71
1.13
0.16
1.0
1.1
—
—
—
0
0
6
76
0.79
0.15
1.0
1.0
288.33
285.55
mg/l
—
6
65
25
226
1.11
0.15
2.0
1.7
56.88
40.39
nmol/l
1.09
25
218
238
2440
0.97
0.15
2.2
2.1
3.03
2.99
mg/l
0.07
200
2056
12
102
1.18
0.15
1.0
1.1
—
—
—
0
0
191
1856
1.03
0.15
3.3
3.8
624.83
366.27
ng/l
0.23
146
1412
9
81
1.11
0.15
3.0
2.2
—
—
—
0
0
231
2253
1.03
0.14
1.5
1.5
21.36
21.01
nmol/l
0.12
200
1922
8
97
0.82
0.13
2.8
2.3
—
—
—
0
0
76
796
0.95
0.13
2.2
1.8
—
—
—
0
0
19
170
1.12
0.13
1.1
1.1
2.88
2.37
u/ml
—
9
89
11
94
1.17
0.13
2.7
2.3
—
—
—
0
0
23
209
1.10
0.13
1.5
2.0
128.06
129.41
g/l
0.09
18
155
9
106
0.85
0.13
5.4
3.6
—
—
—
0
0
16
142
1.13
0.12
1.0
1.0
0.75
1.95
u/ml
—
9
67
73
698
1.05
0.12
1.2
1.2
140.83
143.01
iu/ml
0.01
23
279
12
104
1.16
0.12
1.0
1.0
—
—
—
0
0
16
179
0.89
0.12
1.3
1.2
—
—
—
0
0
298
2928
1.02
0.12
2.8
2.9
7.48
7.57
mmol/l
0.14
268
2491
13
114
1.14
0.12
1.0
1.0
—
—
—
0
0
15
167
0.90
0.10
1.8
1.5
—
—
—
0
0
25
270
0.92
0.10
1.2
1.3
—
—
—
0
0
5
44
1.14
0.10
1.8
2.6
36625.20
38685.18
ug/l
—
5
44
5
45
1.11
0.10
1.2
1.1
—
—
—
0
0
5
47
1.06
0.09
1.0
1.0
—
—
—
0
0
11
124
0.89
0.09
1.5
1.5
—
—
—
0
0
11
124
0.89
0.09
1.5
1.5
—
—
—
0
0
279
2749
1.02
0.09
2.8
3.0
1051.79
315.52
mg/l
0.82
179
1727
15
165
0.91
0.09
1.9
1.8
—
—
—
0
0
6
56
1.07
0.08
18.7
12.9
0.62
0.65
mmol/l
—
6
51
28
263
1.07
0.08
1.4
1.2
—
—
—
0
0
25
267
0.93
0.08
1.4
1.2
—
—
—
0
0
6
72
0.83
0.07
1.3
1.1
—
—
—
0
0
6
72
0.83
0.07
1.3
1.1
—
—
—
0
0
6
73
0.82
0.07
1.3
1.1
—
—
—
0
0
6
73
0.82
0.07
1.3
1.1
—
—
—
0
0
6
73
0.82
0.07
1.3
1.1
—
—
—
0
0
8
74
1.08
0.07
1.5
1.1
—
—
—
0
0
139
1363
1.02
0.07
2.8
2.3
2.36
2.33
g/l
0.21
129
1257
11
122
0.90
0.07
1.5
1.5
—
—
—
0
0
10
89
1.12
0.07
1.2
1.3
—
—
—
0
0
8
91
0.88
0.06
1.0
1.2
—
—
—
0
0
78
801
0.97
0.06
2.6
3.0
130.96
200.82
ng/l
2.03
71
736
55
568
0.97
0.06
3.5
3.3
1.27
1.93
mmol/l
0.89
39
423
21
197
1.07
0.06
3.5
3.7
51.43
57.44
%
1.29
21
197
465
4616
1.01
0.06
2.6
2.5
—
—
—
0
0
19
203
0.93
0.06
2.4
2.3
54.82
102.88
ug/min
0.72
12
124
20
213
0.94
0.06
1.4
1.3
—
—
—
0
0
20
213
0.94
0.06
1.4
1.3
—
—
—
0
0
11
121
0.91
0.06
1.5
1.5
—
—
—
0
0
11
121
0.91
0.06
1.5
1.5
—
—
—
0
0
12
131
0.92
0.05
1.2
1.1
—
—
—
0
0
108
1100
0.98
0.05
5.4
7.5
4.88
5.09
kpa
1.85
103
1049
14
151
0.93
0.05
1.4
1.2
—
—
—
0
0
40
414
0.97
0.05
1.4
1.8
1.43
1.59
g/l
0.54
32
359
12
130
0.92
0.04
1.0
1.0
—
—
—
0
0
15
140
1.07
0.04
2.1
3.7
0.23
1.50
%
3.02
15
125
93
915
1.02
0.04
2.3
2.3
35.84
42.55
u/l
0.56
82
785
12
129
0.93
0.03
1.0
1.6
—
—
—
0
0
15
159
0.94
0.03
1.6
1.5
—
—
—
0
0
15
159
0.94
0.03
1.6
1.5
—
—
—
0
0
17
161
1.06
0.03
1.1
1.1
—
—
—
0
0
20
191
1.05
0.03
3.1
3.5
3.86
4.24
e9/l
0.36
20
191
25
241
1.04
0.02
1.5
1.2
2.14
2.43
u/ml
—
5
27
15
158
0.95
0.02
1.6
1.4
—
—
—
0
0
15
158
0.95
0.02
1.6
1.4
—
—
—
0
0
127
1259
1.01
0.02
3.0
2.4
25.12
22.96
%
1.05
111
1075
16
167
0.96
0.01
1.0
1.6
—
—
—
0
0
25
243
1.03
0.01
1.5
1.2
4.30
11.74
u/ml
—
6
46
26
253
1.03
0.01
2.4
1.8
3.30
5.26
iu/l
1.00
14
85
30
293
1.02
0.01
1.3
1.3
45.54
220.55
miu/ml
8.82
13
147
111
1102
1.01
0.01
5.2
7.5
1.46
1.19
mmol/l
0.42
97
868
15
144
1.04
0.00
1.0
1.1
129.87
115.99
%
0.64
15
133
22
214
1.03
0.00
1.5
1.4
—
—
—
0
0
15
154
0.97
0.00
1.1
1.1
—
—
—
0
0
12
118
1.02
0.00
1.3
1.5
56.33
60.82
%
—
6
73
88
884
1.00
0.00
2.2
1.9
—
—
—
0
0
13
131
0.99
0.00
1.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
10.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.1
1.2
—
—
—
0
0
7
72
0.97
-0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.1
344.40
497.51
u/l
—
5
45
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
15
150
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
2.5
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PERIPHRETINADEGEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PERIPHRETINADEGEN | 0.789 [0.7, 0.88] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.27 |
During the follow-up period (1.1.1998 — 31.12.2019), 516 out of 4493 females with H7_PERIPHRETINADEGEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PERIPHRETINADEGEN | 0.794 [0.7, 0.9] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 436 out of 2702 males with H7_PERIPHRETINADEGEN died.
Mortality risk
Mortality risk for people of age
years, who have H7_PERIPHRETINADEGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.126% |
| 5 | 0.405% | 0.914% |
| 10 | 1.083% | 2.273% |
| 15 | 2.237% | 4.398% |
| 20 | 4.093% | 7.697% |
Relationships between endpoints
↥Index endpoint: H7_PERIPHRETINADEGEN – Peripheral retinal degeneration
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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