age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
845 |
4. Check minimum number of eventsNone |
845 |
5. Include endpointsNone |
845 |
6. Filter based on genotype QC (FinnGen only) |
845 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
- Name in latin
- Haemorrhagia retinae
Similar endpoints
↥List of similar endpoints to
Retinal haemorrhage
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Bleeding
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6470 | 3761 | 2664 |
| Only index persons | 5746 | 3425 | 2321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.07 |
| Only index persons | 0.11 | 0.13 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 71.27 | 74.94 | 66.17 |
| Only index persons | 71.43 | 75.09 | 66.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 845 | 448 | 397 |
| Unadjusted period prevalence (%) | 0.16 | 0.15 | 0.18 |
| Median age at first event (years) | 67.98 | 67.63 | 68.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 743
- Matched controls
- 7431
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
323.0
719
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1194.7
264.6
243
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
315.7
211.9
206
9
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
19.9
151.3
240
174
H43.1
ICD-10 Finland
Vitreous haemorrhage
91.5
145.5
159
22
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.3
115.6
179
114
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.4
111.9
242
328
CKC12
NOMESCO Finland
Photocoagulation of retina
219.2
110.8
112
6
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
86.3
106.0
117
16
XCK10
NOMESCO Finland
Photography of fundus of eye
10.3
102.0
220
291
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
95.1
90.6
99
12
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
252.2
88.5
89
*
WX140
NOMESCO Finland
Parabulbar anesthesy
19.4
86.0
134
83
XCD20
NOMESCO Finland
Photoangiography of eye
294.1
79.1
79
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
281.6
75.9
76
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
68.8
65
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
357.5
66.6
66
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
+∞
58.1
55
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.6
56.6
392
1777
CKD40
NOMESCO Finland
Endophotocoagulation of retina
567.2
54.2
53
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
47.4
53.6
65
15
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
50.6
48
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
48.8
208
607
H3603, E103
ICD-10 Finland
NA
+∞
46.3
44
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
475.4
45.8
45
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.2
42.9
190
567
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
39.8
41.5
52
14
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.9
40.6
356
1773
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
38.9
37
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
37.8
36
*
A10AA01
ATC
NA
19.8
37.6
57
31
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
12.0
37.5
70
64
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.5
37.1
118
247
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
35.7
34
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
5.2
35.3
117
256
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
363.5
35.2
35
*
A10AA02
ATC
NA
10.4
33.0
66
69
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
10.7
33.0
65
66
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
30.3
32.4
43
15
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.3
31.0
124
328
H36.01
ICD-10 Finland
Diabetic maculopathy
166.9
30.9
32
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
114.9
30.9
33
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.1
30.7
103
227
H3603, E113
ICD-10 Finland
NA
+∞
30.4
29
*
T89
ICPC
Diabetes insulin dependent
9.8
29.7
61
67
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
12.3
29.6
54
47
A10AE04
ATC
insulin glargine; parenteral
4.2
28.8
117
313
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
50.7
28.6
34
7
H26.4
ICD-10 Finland
After-cataract
3.8
27.7
130
395
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
27.2
26
*
H04AA01
ATC
glucagon; nasal, parenteral
17.3
26.1
41
25
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
96.9
25.8
28
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
96.9
25.8
28
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
46.1
25.7
31
7
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
11.3
24.9
47
44
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
258.3
24.8
25
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
258.3
24.8
25
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
93.3
24.8
27
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
43.0
23.8
29
7
ZXA10
NOMESCO Finland
Bilateral
2.7
23.5
194
866
XCK00
NOMESCO Finland
Perimetry
4.4
23.1
87
215
XCH00
NOMESCO Finland
Eye pressure measurement
6.1
22.9
64
113
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
22.0
21
*
H3600, E113
ICD-10 Finland
NA
+∞
22.0
21
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
22.0
21
*
H3600, E103
ICD-10 Finland
NA
+∞
22.0
21
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
64.5
22.0
25
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
34.9
21.2
27
8
H3601, E103
ICD-10 Finland
NA
+∞
20.9
20
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
20.9
20
*
ZX198
NOMESCO Finland
Other local administration
43.0
20.6
25
6
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.0
20.1
46
61
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
19.9
19
*
A10AE06
ATC
insulin degludec; parenteral
9.8
19.8
40
43
Z3229
NOMESCO Finland
Other healthcare associate professional
3.5
19.4
98
313
S01ED51
ATC
timolol, combinations; ophthalmic
3.6
19.3
92
281
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
18.9
214
1111
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
18.8
18
*
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
18.8
18
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
18.8
18
*
A10AE05
ATC
insulin detemir; parenteral
4.4
18.4
68
165
1LA05
NOMESCO Finland
NA
+∞
17.8
17
*
H25.8
ICD-10 Finland
Other senile cataract
2.8
17.7
126
507
CKD20
NOMESCO Finland
Removal of vitreous body substitute
184.1
17.6
18
*
ZXA05
NOMESCO Finland
Left side
2.2
17.1
228
1267
H53.1
ICD-10 Finland
Subjective visual disturbances
4.0
16.8
69
185
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
16.8
16.6
26
16
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
16.5
475
3543
C08CA01
ATC
amlodipine; oral
2.0
16.3
309
1976
H33.5
ICD-10 Finland
Other retinal detachments
30.8
16.2
21
7
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
16.0
237
1371
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.0
16.0
66
178
AA1AD
NOMESCO Finland
CT of head and brain
2.1
15.9
216
1204
H3601, E113
ICD-10 Finland
NA
+∞
15.7
15
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
15.7
15
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
15.7
15
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.0
15.0
247
1482
E10
ICD-10 Finland
Type 1 diabetes mellitus
15.4
15.0
24
16
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
14.9
329
2202
H53.4
ICD-10 Finland
Visual field defects
7.1
14.8
36
53
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.7
14.4
26
23
ZXA00
NOMESCO Finland
Right side
2.0
14.0
231
1382
37701
ICD-8 Finland
Other diseases of retina and optic nerve, Haemorrhagia retinae et chorioideae
+∞
13.6
13
*
137
Kela drug reimbursment
Uraemia requiring dialysis
16.6
13.5
21
13
H35.37
ICD-10 Finland
Macular holes
142.4
13.5
14
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
6.4
13.5
35
57
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
21.6
13.4
19
9
Z49.2
ICD-10 Finland
Other dialysis
17.1
13.0
20
12
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
12.9
180
1004
H35.9
ICD-10 Finland
Retinal disorder, unspecified
132.1
12.5
13
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
11.9
12.4
22
19
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
12.4
342
2416
C03CA01
ATC
furosemide; systemic
1.8
12.3
272
1791
127
Kela drug reimbursment
Transplant complication
8.4
12.1
26
32
B05DA
ATC
Isotonic solutions
18.4
12.1
18
10
WX142
NOMESCO Finland
Sub-tenon anesthesy
27.2
12.1
16
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.1
12.1
32
54
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
21.7
12.0
17
8
B03XA02
ATC
darbepoetin alfa; parenteral
6.8
11.8
29
44
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
30.6
11.7
15
5
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
66.0
11.6
13
*
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
11.5
11
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
11.5
11
*
3628A
ICD-9 Finland
Other retinal disorders[HAEMORRHAGIA RETINAE]
+∞
11.5
11
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
+∞
11.5
11
*
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
+∞
11.5
11
*
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
121.8
11.5
12
*
ZXD05
NOMESCO Finland
Urgent procedure
1.8
11.3
242
1565
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
25.4
11.2
15
6
WX002
NOMESCO Finland
Sedation and analgesia
2.0
11.2
164
926
S01BC05
ATC
ketorolac; ophthalmic
3.5
11.0
52
158
S01EC01
ATC
acetazolamide; systemic
5.3
11.0
33
65
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
18.1
10.8
16
9
205
Kela drug reimbursment
Chronic hypertension
1.8
10.6
246
1626
F29
ICPC
Eye symptom/complaint other
2.8
10.4
66
248
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
5.9
10.3
28
49
C02AC05
ATC
moxonidine; oral
3.3
10.3
51
162
TK800
NOMESCO Finland
Hemodialysis
5.7
10.0
28
51
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
17.0
9.9
15
9
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.6
9.9
28
52
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.8
9.7
40
109
A10AA03
ATC
NA
8.5
9.6
20
24
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
9.6
90
419
177
Kela drug reimbursment
Insulin glargine 300 U / ml
7.3
9.6
22
31
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
17.8
9.4
14
8
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
+∞
9.4
9
*
H3602, E103
ICD-10 Finland
NA
+∞
9.4
9
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
9.4
9
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
9.4
102
507
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
9.4
104
521
A12AA04
ATC
calcium carbonate; oral
7.0
9.4
22
32
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.1
9.3
35
88
H16.0
ICD-10 Finland
Corneal ulcer
3.8
9.1
38
105
H26.2
ICD-10 Finland
Complicated cataract
8.4
9.1
19
23
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
24.3
8.9
12
5
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.6
8.9
39
113
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.1
8.9
19
24
V03AE01
ATC
polystyrene sulfonate; oral
9.6
8.8
17
18
N02BE01
ATC
paracetamol; systemic, rectal
1.8
8.7
614
5408
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
8.7
257
1801
WW500
NOMESCO Finland
Blood transfusion
3.3
8.5
41
128
C09CA01
ATC
losartan; oral
1.7
8.4
186
1199
C09AA02
ATC
enalapril; systemic
1.8
8.3
168
1051
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
10.9
8.3
15
14
S01BC03
ATC
diclofenac; ophthalmic
4.3
8.3
29
69
A11CC03
ATC
alfacalcidol; systemic
4.6
8.2
27
60
B05DB
ATC
Hypertonic solutions
14.7
8.2
13
9
H25.0
ICD-10 Finland
Senile incipient cataract
2.6
8.0
58
235
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
8.0
209
1413
C07AB07
ATC
bisoprolol; oral
1.6
7.9
364
2832
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.0
7.9
43
148
J01DB01
ATC
cefalexin; oral
1.6
7.8
559
4834
A98
ICPC
Health maint/preventive medicine
1.9
7.8
664
6047
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
7.8
56
225
WX110
NOMESCO Finland
Local anesthesy
1.5
7.7
443
3626
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
7.7
52
203
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
18.6
7.6
11
6
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.5
76
364
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
3.7
7.4
31
87
CKC20
NOMESCO Finland
Cryopexy of undetached retina
80.8
7.4
8
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
80.8
7.4
8
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
7.8
7.4
16
21
Z94.0
ICD-10 Finland
Kidney transplant status
8.5
7.3
15
18
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
6.9
7.3
17
25
T90
ICPC
Diabetes non-insulin dependent
1.7
7.2
171
1119
S18
ICPC
Laceration/cut
1.5
7.2
293
2200
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
20.2
7.1
10
5
H57.1
ICD-10 Finland
Ocular pain
3.8
7.1
28
75
SPAT1262
SPAT
Handing over of treatment supplies
1.8
7.1
137
839
SPAT1325
SPAT
Vaccination
1.6
7.1
258
1886
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.8
7.0
28
76
L04AD01
ATC
ciclosporin; systemic
5.0
7.0
21
43
L04AA06
ATC
mycophenolic acid; systemic
5.9
6.9
18
31
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
13.9
6.9
11
8
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
6.9
60
271
H40.0
ICD-10 Finland
Glaucoma suspect
2.3
6.8
59
265
CKC60
NOMESCO Finland
Local buckling of sclera using implant
40.4
6.8
8
*
C10AA05
ATC
atorvastatin; oral
1.5
6.8
280
2102
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.2
6.7
24
59
J01MA12
ATC
levofloxacin; systemic
1.7
6.7
134
832
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
22.7
6.7
9
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
6.5
6.7
16
25
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
6.9
6.5
15
22
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
6.5
65
312
J01FF01
ATC
clindamycin; systemic
1.6
6.5
178
1209
WZC30
NOMESCO Finland
Teaching
1.9
6.4
95
535
CKD50
NOMESCO Finland
Endodiathermy of retina
70.4
6.4
7
*
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
70.4
6.4
7
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.4
131
817
TK820
NOMESCO Finland
Peritoneal dialysis
14.5
6.4
10
7
V03AE02
ATC
sevelamer; oral
14.5
6.4
10
7
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.6
6.4
27
78
R51.80
ICD-10 Finland
Headache
1.9
6.3
94
530
Z49.1
ICD-10 Finland
Extracorporeal dialysis
6.0
6.3
16
27
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
3.9
6.3
24
63
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
11.1
6.3
11
10
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.5
6.3
27
79
H28.0
ICD-10 Finland
Diabetic cataract
+∞
6.3
6
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.1
6.2
14
20
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
6.2
72
369
J05AB01
ATC
aciclovir; systemic
1.7
6.2
137
874
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.1
130
818
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.7
6.1
19
41
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.1
180
1242
WW200
NOMESCO Finland
Immunization
3.2
6.1
29
92
Z3231
NOMESCO Finland
Registered nurse
1.6
6.1
189
1320
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
6.1
177
1220
S01EA03
ATC
apraclonidine; ophthalmic
6.8
6.1
14
21
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.0
171
1167
J01CF05
ATC
flucloxacillin; systemic
3.0
6.0
32
110
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINAHAEMORR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINAHAEMORR | 0.987 [0.87, 1.12] | 0.838 |
| Birth year | 0.998 [0.99, 1.01] | 0.6 |
During the follow-up period (1.1.1998 — 31.12.2019), 1022 out of 3021 females with H7_RETINAHAEMORR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINAHAEMORR | 1.254 [1.05, 1.49] | 0.011 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 664 out of 2055 males with H7_RETINAHAEMORR died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINAHAEMORR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.073% | 0.242% |
| 5 | 0.625% | 1.341% |
| 10 | 1.745% | 3.327% |
| 15 | 3.176% | 6.081% |
| 20 | 5.491% | 10.27% |
Relationships between endpoints
↥Index endpoint: H7_RETINAHAEMORR – Retinal haemorrhage
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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