No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
969 |
4. Check minimum number of eventsNone |
969 |
5. Include endpointsNone |
969 |
6. Filter based on genotype QC (FinnGen only) |
969 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H70
- Name in latin
- Mastoiditis chronica
Similar endpoints
↥List of similar endpoints to
Chronic mastoiditis
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8589 | 3987 | 4494 |
| Only index persons | 7007 | 3397 | 3610 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.13 |
| Only index persons | 0.13 | 0.12 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 40.57 | 43.01 | 38.15 |
| Only index persons | 37.44 | 40.07 | 34.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 969 | 433 | 536 |
| Unadjusted period prevalence (%) | 0.20 | 0.15 | 0.24 |
| Median age at first event (years) | 41.15 | 40.26 | 41.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 886
- Matched controls
- 8858
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
323.0
472
*
H70.1
ICD-10 Finland
Chronic mastoiditis
6946.7
323.0
408
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
2735.1
240.9
222
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
317.8
136.4
135
5
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
369.5
128.0
126
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
120.6
113
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
42.8
110.8
138
38
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
370.5
99.1
98
*
DC1AD
NOMESCO Finland
Temporalbone CT
71.0
98.5
112
18
UDC00
NOMESCO Finland
Ear microscopy
9.7
96.7
213
281
H66.0
ICD-10 Finland
Acute suppurative otitis media
16.2
89.2
149
109
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
144.3
75.3
79
6
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.2
73.3
264
665
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
252.9
69.3
70
*
H65.2
ICD-10 Finland
Chronic serous otitis media
252.9
69.3
70
*
DFF00
NOMESCO Finland
Pure tone audiometry
6.4
68.7
200
386
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
68.6
65
*
H66.9
ICD-10 Finland
Otitis media, unspecified
12.0
67.2
128
123
DCD00
NOMESCO Finland
Myringoplasty
663.5
63.7
62
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.1
63.6
303
991
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
594.6
57.3
56
*
S02CA02
ATC
flumetasone and antiinfectives; otic
7.5
56.4
142
220
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
53.7
51
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
119.4
52.4
56
5
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
49.4
47
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
49.4
47
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
48.4
46
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
13.1
48.3
87
73
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
46.2
44
*
H60.3
ICD-10 Finland
Other infective otitis externa
13.6
45.4
80
64
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.0
44.1
329
1447
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
5.2
43.6
147
327
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.2
42.4
121
220
DEB30
NOMESCO Finland
Radical mastoidectomy
+∞
40.9
39
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
37.8
36
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
371.7
36.2
36
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
8.2
36.1
83
110
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
35.7
34
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
81.6
35.1
39
5
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.6
34.6
106
209
4151
FHL
Reoperation for chronic otitis media
339.1
33.1
33
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
121.3
32.9
35
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
32.5
31
*
TDA90
NOMESCO Finland
Removal wax from ear
15.1
32.3
54
38
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
32.3
480
2969
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
16.3
31.6
51
33
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
30.4
29
*
H60.8
ICD-10 Finland
Other otitis externa
10.2
30.3
61
64
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.6
30.0
91
177
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
16.3
29.7
48
31
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
29.3
28
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
22.0
28.9
42
20
H65.0
ICD-10 Finland
Acute serous otitis media
37.4
28.5
36
10
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
290.2
27.9
28
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
290.2
27.9
28
*
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
64.1
27.1
31
5
H70.0
ICD-10 Finland
Acute mastoiditis
279.1
26.9
27
*
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
3.8
26.3
120
351
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
26.2
25
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
26.2
25
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
26.0
166
626
R5120
NOMESCO Finland
Preparation of an aid
7.1
26.0
65
98
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
7.2
25.0
62
92
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
256.9
24.8
25
*
4122
FHL
Tympanostomy (tympanic tube)
256.9
24.8
25
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
42.7
23.7
29
7
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
23.0
22
*
DFF15
NOMESCO Finland
Speech audiometry
4.5
21.1
77
183
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
20.9
20
*
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
20.9
20
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.4
20.5
63
124
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
19.9
19
*
DEB00
NOMESCO Finland
Cortical mastoidectomy
+∞
18.8
18
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
8.7
18.6
40
48
J01DA06
ATC
[U] cefuroxime; systemic
2.5
17.9
154
684
J01FF01
ATC
clindamycin; systemic
2.0
16.2
249
1441
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
+∞
15.7
15
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.6
14.7
116
489
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
14.6
14
*
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
14.6
14
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
14.6
14
*
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
14.6
14
*
J01DA01
ATC
[U] cefalexin; systemic
1.8
14.5
551
4279
DAX08
NOMESCO Finland
Fitting of hearing aid
3.5
14.3
67
200
J01CA04
ATC
amoxicillin; systemic
1.8
14.2
666
5512
H61.2
ICD-10 Finland
Impacted cerumen
3.2
13.8
74
245
R01AD08
ATC
fluticasone; nasal
1.9
13.7
240
1444
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
76.3
13.6
15
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
13.6
13
*
3831A
ICD-9 Finland
Mastoiditis and related conditions, Chronic mastoiditis
+∞
13.6
13
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
34.6
13.5
17
5
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
142.1
13.5
14
*
H04
ICPC
Ear discharge
4.2
13.4
50
123
H92.0
ICD-10 Finland
Otalgia
3.8
12.9
54
147
J01MA02
ATC
ciprofloxacin; systemic
1.7
12.8
364
2556
H60
ICD-10 Finland
Otitis externa
3.8
12.6
53
145
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
131.8
12.5
13
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
131.8
12.5
13
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.7
12.1
52
145
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.3
12.1
44
106
4143
FHL
Atticotomy or atticoanthromy through the ear canal
+∞
11.5
11
*
J01FA10
ATC
azithromycin; systemic
1.6
11.4
432
3257
H92.1
ICD-10 Finland
Otorrhoea
35.5
11.3
14
*
J01DC02
ATC
cefuroxime; systemic
3.2
11.1
57
184
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
9.4
11.0
22
24
DC1BD
NOMESCO Finland
Temporal bone extensive CT
+∞
10.4
10
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
10.4
10
*
4451
FHL
Guitar cutting
8.3
10.4
22
27
H02AB04
ATC
methylprednisolone; systemic
2.0
10.1
133
712
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.9
389
2923
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.7
9.8
66
255
H02AB06
ATC
prednisolone; systemic
1.6
9.7
399
3021
1450
FHL
Otomicroscopy
55.6
9.7
11
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.7
9.4
40
112
38310
ICD-8 Finland
Mastoiditis without mention of otitis media, Chronic
+∞
9.4
9
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
9.4
9
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
9.4
9
*
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
4.8
8.8
28
60
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.2
8.8
45
147
H01
ICPC
Ear pain/earache
2.2
8.6
84
394
RK320
NOMESCO Finland
NA
7.0
8.6
20
29
H60.0
ICD-10 Finland
Abscess of external ear
16.5
8.6
13
8
J01DB01
ATC
cefalexin; oral
1.6
8.4
666
5810
4146
FHL
Radical cutting (bridge broken)
+∞
8.3
8
*
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
8.3
8
*
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
8.3
8
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
14.6
8.2
13
9
ZXA00
NOMESCO Finland
Right side
1.6
8.1
240
1658
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.0
231
1584
RK420
NOMESCO Finland
NA
45.4
7.7
9
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
7.7
228
1572
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
7.7
70
318
J33.8
ICD-10 Finland
Other polyp of sinus
4.0
7.6
29
75
J01DA08
ATC
[U] cefaclor; oral
2.2
7.5
76
364
R03DC03
ATC
montelukast; oral
1.8
7.4
119
687
50300
ICD-8 Finland
Chronic sinusitis, Maxillaris cum empyemate
8.5
7.3
15
18
38200
ICD-8 Finland
Acute / Acute otitis media with mastoiditis
+∞
7.3
7
*
DC1AA
NOMESCO Finland
Temporalbone X-ray examination
+∞
7.3
7
*
H70.9
ICD-10 Finland
Mastoiditis, unspecified
+∞
7.3
7
*
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
7.3
7
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
7.2
211
1446
S02CA03
ATC
hydrocortisone and antiinfectives; otic
30.3
7.2
9
*
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
8.9
7.1
14
16
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.1
7.0
36
119
J01MA12
ATC
levofloxacin; systemic
1.7
6.9
169
1105
R01AD09
ATC
mometasone; nasal
1.5
6.9
319
2427
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
6.8
147
928
N07CA01
ATC
betahistine; oral
2.1
6.8
72
354
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
16.8
6.8
10
6
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.7
171
1131
D07AC01
ATC
betamethasone; topical
1.5
6.7
268
1977
WX110
NOMESCO Finland
Local anesthesy
1.4
6.6
522
4412
RK520
NOMESCO Finland
NA
8.8
6.6
13
15
H29
ICPC
Ear symptom/complaint other
2.0
6.5
88
474
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.5
145
923
J01FA09
ATC
clarithromycin; systemic
1.5
6.5
230
1650
38799
ICD-8 Finland
Other disease of ear and mastoid process, Other
70.3
6.4
7
*
AA1AD
NOMESCO Finland
CT of head and brain
1.5
6.4
209
1473
A02BC01
ATC
omeprazole; systemic
1.5
6.3
236
1707
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
5.6
6.3
17
31
J47
ICD-10 Finland
Bronchiectasis
4.0
6.3
23
58
H02AB07
ATC
prednisone; oral
1.7
6.3
123
751
ZXA05
NOMESCO Finland
Left side
1.5
6.3
212
1498
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
4.4
6.3
21
49
H60.2
ICD-10 Finland
Malignant otitis externa
+∞
6.3
6
*
4148
FHL
Radical cutting and cavity filling
+∞
6.3
6
*
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
+∞
6.3
6
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
6.2
61
291
EMB30
NOMESCO Finland
Adenotomy
10.1
6.0
11
11
R03AC02
ATC
salbutamol; inhalant
1.4
6.0
396
3212
S02AA03
ATC
boric acid; otic
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
170
980
1.89
11.76
4.8
4.6
31.6
32.1
%
0.21
125
641
104
545
2.02
9.44
3.2
3.7
5.2
5.2
kpa
0.08
97
504
99
510
2.05
9.42
3.2
3.8
1.3
1.8
mmol/l
0.64
79
384
63
316
2.06
6.48
1.8
1.6
—
—
—
0
0
643
5647
1.41
5.89
4.8
4.1
14.3
13.2
mm/h
0.99
601
5171
315
2456
1.42
5.82
2.7
2.6
50.4
56.7
u/l
4.17
293
2280
562
4838
1.38
5.71
3.4
3.2
58.1
51.6
u/l
0.60
520
4477
437
3645
1.36
5.24
5.9
6.1
1.2
1.2
mmol/l
2.31
388
3274
193
1410
1.46
4.98
2.0
1.8
—
—
—
0
0
537
4659
1.34
4.81
5.3
5.0
7.0
6.8
mmol/l
1.43
510
4377
62
345
1.85
4.78
1.9
1.7
—
—
—
0
0
388
3213
1.35
4.74
4.4
3.9
38.5
54.7
ng/l
0.76
293
2369
321
2589
1.36
4.63
3.3
3.1
1927.3
1623.9
ng/l
0.60
277
2229
629
5604
1.35
4.63
4.2
3.8
15.1
14.9
pmol/l
0.57
556
5025
270
2125
1.38
4.53
2.4
2.1
3.0
3.1
mg/l
0.09
224
1789
113
752
1.57
4.53
3.6
3.0
205.1
227.6
ng/l
0.25
102
689
466
3992
1.32
4.41
5.9
6.8
1.2
1.2
mmol/l
1.66
379
3356
660
5976
1.33
4.03
8.2
7.6
79.9
79.6
u/l
0.06
613
5593
299
2435
1.33
3.94
2.3
2.2
167.6
246.9
u/l
1.41
284
2292
214
1667
1.36
3.76
1.8
1.8
1101.0
1193.6
nmol/l
0.66
152
1237
239
1897
1.34
3.72
2.9
2.4
—
—
—
0
0
574
5141
1.29
3.57
5.4
4.8
5.9
3244.9
e6/l
—
7
91
394
3373
1.28
3.49
2.2
2.1
96.7
93.9
pmol/l
0.44
200
1758
753
7025
1.32
3.24
6.8
6.2
41.6
40.5
mmol/mol
2.43
676
6461
406
3520
1.26
3.16
4.3
4.8
34.2
35.0
g/l
2.04
377
3253
734
6846
1.30
3.02
5.1
4.7
2.0
2.0
mu/l
0.02
657
6165
300
2522
1.27
2.98
3.8
3.2
7.1
7.5
mmol/l
0.95
228
2087
50
303
1.69
2.98
2.8
2.9
—
—
—
0
0
106
767
1.43
2.88
1.9
2.2
0.2
0.2
g/l
0.04
94
706
466
4139
1.24
2.84
5.9
6.3
10.6
12.0
umol/l
3.02
451
3927
165
1289
1.34
2.82
2.8
3.3
0.8
0.8
mmol/l
1.07
156
1206
303
2566
1.26
2.81
4.3
4.0
8.3
8.7
mg/mmol
0.05
175
1649
27
139
1.97
2.72
3.1
2.9
4.3
4.4
e9/l
0.03
27
139
41
242
1.72
2.71
1.9
1.6
—
—
—
0
0
53
336
1.61
2.68
2.0
2.0
36.7
38.7
u/l
0.32
44
294
204
1654
1.30
2.67
1.6
1.7
1.3
1.4
mg/l
0.07
151
1277
141
1086
1.35
2.65
4.3
5.6
1.0
1.0
mmol/l
0.01
124
996
164
1292
1.32
2.65
3.0
2.5
12.1
12.7
umol/l
0.52
154
1193
51
322
1.62
2.63
4.3
3.1
81.3
59.1
u/ml
0.20
51
308
200
1623
1.29
2.60
4.9
3.9
161.7
275.2
ng/l
0.96
164
1323
408
3605
1.23
2.52
4.8
4.1
—
—
—
0
0
28
152
1.87
2.44
1.2
1.1
—
—
—
0
0
27
145
1.89
2.43
3.8
3.2
59.6
58.8
%
0.09
27
145
117
888
1.36
2.43
2.6
2.9
8.2
9.5
umol/l
0.38
102
786
794
7545
1.29
2.42
19.7
15.7
25.3
26.1
mg/l
0.25
679
6068
12
47
2.57
2.27
2.8
2.5
—
—
—
0
0
370
3264
1.22
2.27
3.2
2.8
139.6
142.4
ug/l
0.08
324
2963
35
210
1.69
2.22
1.5
2.5
3.6
3.6
g/l
0.03
30
201
30
173
1.76
2.19
2.0
2.2
119.4
126.8
g/l
1.16
21
125
484
4393
1.20
2.18
8.9
8.9
4.3
4.2
e9/l
0.26
427
3840
31
182
1.73
2.13
1.6
1.3
—
—
—
0
0
31
182
1.73
2.13
1.6
1.3
—
—
—
0
0
99
750
1.36
2.10
6.3
7.3
10.9
10.5
mmol/l
0.18
94
715
148
1188
1.29
2.09
3.1
2.5
2.3
2.3
g/l
0.12
140
1106
8
26
3.09
2.01
1.5
1.4
—
—
—
0
0
35
217
1.64
1.99
1.5
1.6
0.0
27.4
iu/ml
—
8
44
5
11
4.56
1.94
1.0
1.4
—
—
—
0
0
744
7070
1.23
1.94
4.4
4.1
1.4
1.3
mmol/l
1.89
655
6373
11
45
2.46
1.93
1.2
1.1
—
—
—
0
0
11
45
2.46
1.93
1.2
1.1
—
—
—
0
0
73
534
1.40
1.93
1.8
1.6
—
—
—
0
0
6
17
3.54
1.84
1.3
2.1
137.8
130.2
nmol/l
—
6
17
10
40
2.52
1.84
1.2
2.4
—
—
—
0
0
138
1122
1.27
1.78
3.2
2.5
20.1
22.6
%
1.22
119
962
19
102
1.88
1.77
2.6
2.6
16.6
23.4
mg/l
—
7
27
89
684
1.33
1.75
2.7
2.1
409.9
377.8
nmol/l
0.49
77
624
236
2039
1.21
1.74
2.8
2.8
3043.9
8010.7
umol/l
1.52
202
1740
11
48
2.31
1.71
1.7
1.1
—
—
—
0
0
17
89
1.93
1.70
1.1
1.1
0.2
1.3
u/ml
—
8
41
138
1665
0.80
1.65
3.7
4.4
1.0
1.0
kg/l
0.52
28
221
209
1795
1.21
1.63
1.7
1.7
405.7
19204819.1
pmol/l
1.55
168
1458
5
14
3.58
1.61
1.0
1.2
—
—
—
0
0
280
2475
1.18
1.60
3.3
3.3
31.4
35.5
u/l
1.43
260
2347
31
200
1.57
1.55
1.4
1.5
—
—
—
0
0
78
600
1.33
1.54
1.6
1.6
—
—
—
0
0
8
33
2.44
1.54
1.0
1.6
—
—
—
0
0
19
108
1.77
1.51
1.2
1.5
—
—
—
0
0
6
21
2.87
1.50
1.0
1.4
—
—
—
0
0
33
218
1.53
1.50
2.2
2.1
11.7
12.2
mg/l
0.16
27
193
44
614
0.70
1.49
3.0
2.9
62.3
62.0
ml/min/173m2
0.02
20
255
456
4209
1.16
1.48
2.8
2.8
—
—
—
0
0
9
37
2.45
1.48
1.0
1.2
—
—
—
0
0
235
2059
1.19
1.48
1.7
1.6
18.1
20.4
nmol/l
1.61
192
1730
342
3092
1.16
1.46
2.2
2.3
79.6
77.8
nmol/l
0.49
287
2705
120
992
1.24
1.37
2.0
1.8
—
—
—
0
0
760
7312
1.18
1.36
4.8
4.5
1.4
1.4
mmol/l
3.19
668
6637
44
317
1.41
1.33
2.0
2.1
248.5
540.4
ug/l
0.97
44
297
136
1146
1.22
1.30
32.2
27.4
1.4
1.4
inr
0.02
24
150
81
1008
0.79
1.29
7.1
7.7
—
—
—
0
0
29
195
1.50
1.25
1.3
1.2
—
19.3
—
0
8
19
116
1.65
1.22
1.1
1.6
—
—
—
0
0
821
7972
1.20
1.22
12.3
10.8
26.1
25.9
u/l
0.16
791
7664
5
19
2.64
1.21
1.0
1.8
1.2
1.2
mmol/l
—
5
19
8
37
2.17
1.21
3.3
4.6
—
—
—
0
0
26
172
1.53
1.21
1.3
1.5
—
—
—
0
0
6
127
0.47
1.17
2.2
1.5
—
—
—
0
0
737
7102
1.16
1.17
18.5
14.7
77.2
77.1
ml/min/173m2
0.03
648
5875
808
7842
1.18
1.16
22.8
18.6
139.5
139.6
mmol/l
0.67
788
7634
809
7854
1.18
1.15
22.9
18.7
4.0
4.0
mmol/l
0.10
788
7635
779
7542
1.17
1.14
5.3
5.1
2.6
2.7
mmol/l
0.57
681
6854
17
103
1.66
1.13
1.4
1.3
—
—
—
0
0
17
103
1.66
1.13
1.4
1.3
—
—
—
0
0
29
202
1.45
1.08
1.7
1.6
—
—
—
0
0
105
881
1.22
1.08
4.4
3.6
—
—
—
0
0
762
7375
1.16
1.07
4.9
4.6
4.4
4.5
mmol/l
1.50
681
6740
118
1002
1.20
1.07
7.1
7.4
5.2
5.1
kpa
0.28
111
963
118
1003
1.20
1.06
7.1
7.4
11.9
11.9
kpa
0.02
111
966
588
6152
0.89
1.04
23.7
19.2
13.9
13.8
%
0.80
575
6026
757
7335
1.15
1.00
5.2
4.8
6.1
6.0
mmol/l
1.10
674
6608
19
123
1.56
1.00
1.2
1.4
—
—
—
0
0
33
240
1.39
0.99
1.2
1.2
—
—
—
0
0
9
49
1.84
0.98
1.1
1.1
—
—
—
0
0
9
49
1.84
0.98
1.1
1.1
—
—
—
0
0
11
61
1.81
0.98
1.1
1.2
—
—
—
0
0
173
1531
1.16
0.98
1.3
1.2
4.1
1.6
u/ml
0.48
36
410
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
39
293
1.34
0.97
2.2
2.5
0.3
0.4
u/ml
1.38
22
168
9
50
1.81
0.96
1.1
1.1
—
—
—
0
0
9
50
1.81
0.96
1.1
1.1
—
—
—
0
0
9
50
1.81
0.96
1.1
1.1
—
—
—
0
0
117
1004
1.19
0.96
7.2
7.5
1.5
1.2
mmol/l
0.37
95
779
11
62
1.78
0.94
1.6
1.3
16.7
13.3
u/l
0.64
11
56
16
101
1.59
0.94
1.4
1.3
—
—
—
0
0
330
3056
1.12
0.93
5.0
5.2
2.2
3.3
ug/l
1.86
276
2713
50
394
1.28
0.91
3.4
3.1
4.5
4.5
pmol/l
0.12
40
339
21
143
1.48
0.90
1.2
1.5
—
—
—
0
0
194
1744
1.14
0.88
3.0
2.6
6.4
4.9
e6/l
0.61
165
1538
84
708
1.20
0.86
2.0
2.8
66.8
66.1
g/l
0.33
78
640
16
104
1.55
0.85
1.4
1.3
—
—
—
0
0
42
327
1.30
0.85
1.1
1.0
—
—
—
0
0
144
1275
1.15
0.82
2.0
2.0
29.8
29.9
s
0.10
136
1231
6
32
1.88
0.82
1.3
1.3
—
—
—
0
0
12
73
1.65
0.82
1.5
1.4
—
—
—
0
0
24
172
1.41
0.81
2.8
2.4
15.1
15.6
%
0.34
15
83
25
181
1.39
0.80
1.2
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
6
34
1.77
0.76
1.0
1.1
—
—
—
0
0
6
34
1.77
0.76
1.0
1.4
—
—
—
0
0
12
75
1.61
0.75
1.7
1.3
7591.5
147058.9
e6/l
—
6
51
7
38
1.85
0.73
1.0
1.6
—
—
—
0
0
7
38
1.85
0.73
1.0
1.6
—
—
—
0
0
5
25
2.01
0.72
5.2
1.9
2.4
8.9
nmol/l
—
5
20
7
39
1.80
0.72
1.0
1.5
—
—
—
0
0
113
995
1.15
0.71
2.0
1.8
—
—
—
0
0
5
26
1.93
0.70
1.0
1.1
105.3
136.5
iu/ml
—
5
26
9
145
0.62
0.69
1.2
1.4
—
—
—
0
0
273
2921
0.91
0.67
4.1
4.1
—
—
—
0
0
28
215
1.31
0.65
1.4
1.3
—
—
—
0
0
15
103
1.46
0.65
1.4
1.3
—
—
—
0
0
15
103
1.46
0.65
1.4
1.3
—
—
—
0
0
690
6712
1.10
0.65
20.8
17.0
39.0
39.4
%
0.43
428
4513
105
931
1.14
0.62
3.0
4.1
236.0
254.4
u/l
0.91
100
884
8
49
1.64
0.62
1.0
1.5
—
—
—
0
0
8
49
1.64
0.62
1.0
1.5
—
—
—
0
0
8
49
1.64
0.62
1.0
1.5
—
—
—
0
0
8
49
1.64
0.62
1.0
1.5
—
—
—
0
0
13
88
1.48
0.60
1.3
1.6
—
—
—
0
0
30
236
1.28
0.60
1.8
1.8
—
—
—
0
0
17
232
0.73
0.60
1.3
1.2
—
—
—
0
0
8
52
1.54
0.59
1.5
1.9
16.4
19.5
nmol/l
—
8
45
18
131
1.38
0.59
2.3
3.5
2.3
1.5
%
0.19
13
107
26
332
0.78
0.59
1.3
1.3
—
—
—
0
0
17
231
0.73
0.59
1.3
1.2
—
—
—
0
0
25
193
1.30
0.58
1.5
1.5
42852.4
15012.8
e6/l
0.35
18
139
6
36
1.67
0.56
1.0
1.0
—
—
—
0
0
5
90
0.55
0.56
1.0
1.0
—
—
—
0
0
10
65
1.54
0.55
1.1
1.6
—
23.0
—
0
14
6
37
1.63
0.55
3.5
2.4
419.7
917.2
u/ml
—
6
37
214
1995
1.09
0.53
1.7
1.6
1.4
1.4
mmol/l
0.87
174
1645
17
226
0.75
0.52
1.4
1.7
—
—
—
0
0
16
117
1.37
0.52
1.4
1.3
—
—
—
0
0
16
117
1.37
0.52
3.5
2.0
32.3
32.4
pg
0.04
16
117
12
83
1.45
0.52
1.3
1.6
—
—
—
0
0
43
361
1.20
0.51
1.8
1.8
1.0
2.3
ug/l
0.71
37
319
16
118
1.36
0.50
1.4
1.1
—
—
—
0
0
189
1758
1.09
0.50
3.2
3.2
0.9
0.8
ug/l
0.48
120
1188
361
3775
0.93
0.50
4.1
3.9
0.0
0.0
estimate
0.50
80
695
6
41
1.47
0.50
1.0
1.2
112.7
74.6
u/l
—
6
36
843
8313
1.11
0.49
28.4
23.1
132.9
134.5
g/l
2.30
830
8164
22
172
1.29
0.48
1.4
1.3
—
—
—
0
0
7
46
1.53
0.48
1.3
1.6
—
—
—
0
0
357
3725
0.93
0.46
5.4
5.3
0.0
0.0
estimate
0.00
84
716
70
619
1.14
0.46
3.3
3.8
88.6
89.0
ng/l
0.02
54
540
7
51
1.38
0.44
1.4
1.6
—
—
—
0
0
194
2066
0.92
0.44
4.3
4.2
0.0
0.0
estimate
0.50
83
687
22
175
1.26
0.43
1.2
1.3
—
—
—
0
0
13
96
1.36
0.41
1.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.0
1.5
—
227.8
—
0
9
10
136
0.73
0.38
1.2
1.2
32.2
37.4
u/l
—
10
118
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
9
70
1.29
0.36
1.0
1.1
—
—
—
0
0
287
2749
1.06
0.36
3.1
3.4
2.3
2.3
mmol/l
0.10
240
2377
9
71
1.27
0.36
1.2
1.2
13.8
13.5
u/l
—
9
62
34
291
1.17
0.36
1.9
2.8
0.3
1.6
g/l
2.99
28
248
147
1568
0.93
0.36
2.8
3.1
2.5
2.5
mmol/l
0.31
127
1379
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
16
200
0.80
0.34
1.1
1.3
—
—
—
0
0
6
45
1.34
0.33
1.0
1.4
—
—
—
0
0
6
45
1.34
0.33
1.3
1.6
—
—
—
0
0
6
45
1.34
0.33
1.0
1.4
—
—
—
0
0
55
611
0.89
0.32
2.2
2.2
12.0
13.0
nmol/l
0.34
46
539
16
129
1.24
0.30
1.6
1.6
—
—
—
0
0
33
287
1.16
0.30
3.8
3.9
42.3
76.7
mg/l
0.86
27
232
10
75
1.34
0.30
3.1
2.5
—
—
—
0
0
7
56
1.25
0.29
1.0
1.4
—
51.3
—
0
8
44
492
0.89
0.29
2.3
1.9
—
—
—
0
0
80
738
1.09
0.29
3.0
2.5
30.2
33.7
u/l
0.67
65
619
127
1197
1.07
0.28
1.4
1.3
16.2
35.1
iu/ml
5.79
34
376
9
118
0.76
0.27
2.3
2.5
—
878.4
—
0
8
363
3733
0.96
0.27
3.8
3.8
0.0
0.0
estimate
0.00
85
717
112
1052
1.07
0.27
1.7
1.4
—
—
—
0
0
8
66
1.21
0.26
1.0
1.2
—
—
—
0
0
131
1384
0.94
0.26
3.5
2.9
1.6
1.2
e6/l
0.46
70
828
18
151
1.20
0.25
1.3
1.7
—
—
—
0
0
9
75
1.20
0.25
1.4
1.6
—
—
—
0
0
26
227
1.15
0.24
1.4
1.4
369.2
283.3
ug/g
—
9
135
82
766
1.08
0.23
2.0
2.6
4.6
6.4
ug/l
1.02
70
677
17
143
1.19
0.23
1.2
1.2
—
29.1
—
0
12
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
91
858
1.07
0.21
3.1
4.2
13.8
26.6
ug/l
0.50
70
721
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
—
—
0
0
120
1143
1.06
0.20
1.4
1.3
8.3
8.9
u/ml
0.05
34
412
0
14
0.00
0.20
0.0
2.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
48
1.25
0.20
1.2
1.2
—
13.6
—
0
13
32
288
1.11
0.20
3.8
4.0
47.7
50.0
mg/l
0.04
26
234
6
49
1.23
0.20
2.7
1.5
—
—
—
0
0
15
127
1.18
0.19
3.9
2.4
3063.3
3128.1
u/l
—
6
46
6
51
1.18
0.19
1.2
1.6
—
—
—
0
0
6
51
1.18
0.19
1.0
1.6
0.9
1.0
g/l
—
6
51
20
175
1.15
0.18
1.1
1.1
—
—
—
0
0
48
518
0.92
0.18
1.4
1.5
—
—
—
0
0
86
815
1.06
0.18
1.6
1.8
1.7
1.5
%
1.02
75
706
5
66
0.76
0.17
2.2
2.1
6.8
4.0
mg/l
—
5
61
21
186
1.13
0.17
4.8
3.7
76.0
30.8
mg/l
—
8
122
10
120
0.83
0.16
1.5
1.6
—
—
—
0
0
8
68
1.18
0.16
1.0
1.2
—
—
—
0
0
8
71
1.13
0.16
1.0
1.9
—
—
—
0
0
53
565
0.93
0.16
6.0
6.3
25.4
24.4
mmol/l
1.46
48
532
9
78
1.16
0.15
1.4
1.4
—
—
—
0
0
9
78
1.16
0.15
1.4
1.4
—
—
—
0
0
9
78
1.16
0.15
1.0
1.1
—
—
—
0
0
9
78
1.16
0.15
1.4
1.4
—
—
—
0
0
87
830
1.05
0.15
8.3
8.1
123.8
119.9
g/l
1.01
82
801
9
80
1.13
0.15
1.4
1.5
—
—
—
0
0
19
169
1.13
0.14
1.4
1.6
2.4
5.6
iu/l
—
8
51
11
93
1.18
0.14
1.5
1.4
—
—
—
0
0
9
110
0.82
0.13
1.1
1.1
—
—
—
0
0
24
219
1.10
0.12
3.0
2.5
111.6
80.3
ug/min
0.29
17
125
51
538
0.95
0.12
2.3
2.0
—
—
—
0
0
30
323
0.93
0.12
2.5
3.3
28.0
11988.0
u/ml
0.79
23
275
30
280
1.07
0.10
4.0
3.9
1.7
1.8
ratio
—
7
28
31
331
0.93
0.10
1.2
2.5
3.8
3.8
g/l
0.07
23
235
31
331
0.93
0.10
1.2
2.5
—
—
—
0
0
31
331
0.93
0.10
1.2
2.5
7.7
7.4
g/l
0.29
25
245
18
197
0.91
0.10
2.9
3.3
1.7
1.6
mmol/l
0.20
18
192
41
431
0.95
0.09
1.2
1.2
91.6
145.5
iu/ml
0.81
17
169
230
2263
1.02
0.09
3.9
3.2
0.3
0.5
e6/l
2.36
182
1741
6
57
1.05
0.08
1.3
1.5
—
—
—
0
0
82
845
0.97
0.08
1.3
1.4
—
—
—
0
0
54
519
1.04
0.08
1.5
1.7
—
—
—
0
0
5
65
0.77
0.08
1.2
1.0
—
—
—
0
0
70
677
1.04
0.08
5.0
3.7
1.2
1.2
mmol/l
0.33
58
583
7
66
1.06
0.08
1.4
1.5
—
—
—
0
0
133
1302
1.02
0.08
3.4
3.2
1.9
2.1
e6/l
0.24
71
755
8
78
1.03
0.07
1.0
1.5
—
—
—
0
0
8
78
1.03
0.07
1.0
1.5
—
—
—
0
0
8
78
1.03
0.07
1.0
1.5
—
—
—
0
0
21
197
1.07
0.06
1.3
1.6
—
—
—
0
0
242
2448
0.98
0.06
4.0
4.5
21.6
21.4
%
0.06
113
1220
23
217
1.06
0.06
3.7
3.3
0.7
0.8
nmol/l
0.61
18
175
21
222
0.94
0.05
1.1
1.6
—
—
—
0
0
15
140
1.07
0.04
1.1
1.2
—
—
—
0
0
10
92
1.09
0.03
3.3
3.5
—
—
—
0
0
13
122
1.07
0.02
3.7
2.9
5.5
36.7
u/ml
0.49
13
117
16
168
0.95
0.02
1.3
1.4
—
—
—
0
0
294
2951
0.99
0.01
3.8
3.3
—
—
—
0
0
21
203
1.04
0.01
1.8
1.7
—
—
—
0
0
21
203
1.04
0.01
1.3
1.6
—
—
—
0
0
11
108
1.02
0.00
2.4
1.9
85.2
89.6
%
0.45
11
108
10
97
1.03
0.00
1.5
1.8
—
—
—
0
0
25
251
1.00
0.00
1.8
1.8
—
—
—
0
0
13
131
0.99
0.00
1.2
1.1
—
—
—
0
0
8
88
0.91
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
31
310
1.00
0.00
1.2
2.6
2.9
3.2
g/l
1.17
23
239
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
0.00
1.0
1.0
—
—
—
0
0
24
240
1.00
0.00
2.1
1.8
5.3
3.2
mg/l
0.50
18
181
0
5
0.00
0.00
0.0
1.6
—
2.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
384.8
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
15
150
1.00
0.00
1.4
1.3
151.2
251.5
miu/ml
—
6
62
78
780
1.00
0.00
3.1
3.6
1.9
2.0
mmol/l
0.12
68
620
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.9
—
—
—
0
0
7
69
1.01
0.00
1.3
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MASTCHRON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MASTCHRON | 1.062 [0.92, 1.23] | 0.423 |
| Birth year | 0.993 [0.98, 1.0] | 0.116 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 1336 females with H8_MASTCHRON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MASTCHRON | 1.065 [0.91, 1.24] | 0.417 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 353 out of 1435 males with H8_MASTCHRON died.
Mortality risk
Mortality risk for people of age
years, who have H8_MASTCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.166% |
| 5 | 0.55% | 1.315% |
| 10 | 1.418% | 3.106% |
| 15 | 2.849% | 5.996% |
| 20 | 5.255% | 10.158% |
Relationships between endpoints
↥Index endpoint: H8_MASTCHRON – Chronic mastoiditis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data