Chronic mastoiditis

H8_MASTCHRON

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H70.1
  • Hospital discharge: ICD-9 3831
  • Hospital discharge: ICD-8 3821|3831
  • Cause of death: ICD-10 H70.1
  • Cause of death: ICD-9 3831
  • Cause of death: ICD-8 3821|3831

2 out of 7 registries used, show all original rules.

983

4. Check minimum number of events

None

983

5. Include endpoints

None

983

6. Filter based on genotype QC (FinnGen only)

944

Control definitions (FinnGen only)

Control exclude
H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H70
Name in latin
Mastoiditis chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8589 3987 4494
Only index persons 7007 3397 3610
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.13 0.12 0.14
Median age at first event (years)
Whole population 40.57 43.01 38.15
Only index persons 37.44 40.07 34.97

-FinnGen-

Key figures

All Female Male
Number of individuals 944 419 525
Unadjusted period prevalence (%) 0.20 0.15 0.24
Median age at first event (years) 41.31 40.38 42.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
983
Matched controls
9830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
307.7
458
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
307.7
520
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
278.8
254
*
DC1AD
NOMESCO Finland
Temporalbone CT
147.0
278.6
139
11
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
37.8
255.9
162
51
H66.0
ICD-10 Finland
Acute suppurative otitis media
12.8
170.5
179
168
UDC00
NOMESCO Finland
Ear microscopy
9.2
170.2
239
333
H65.3
ICD-10 Finland
Chronic mucoid otitis media
465.3
162.5
158
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
440.7
154.8
151
*
H66.9
ICD-10 Finland
Otitis media, unspecified
12.8
147.3
152
138
DFF00
NOMESCO Finland
Pure tone audiometry
6.5
136.0
272
548
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
133.4
125
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
49.2
125.0
73
16
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.4
122.1
317
803
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
214.6
112.1
114
6
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
13.4
95.4
93
76
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.9
86.4
352
1221
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
26.6
86.2
60
24
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
122.2
83.4
89
8
S02CA02
ATC
flumetasone and antiinfectives; otic
6.4
82.9
151
271
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
185.8
82.5
85
5
H60.3
ICD-10 Finland
Other infective otitis externa
10.7
79.5
90
92
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
21.2
78.9
60
30
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.1
78.0
150
283
H65.2
ICD-10 Finland
Chronic serous otitis media
278.1
76.6
77
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
76.0
72
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
5.2
74.8
175
394
DCD00
NOMESCO Finland
Myringoplasty
+∞
73.9
70
*
H65.0
ICD-10 Finland
Acute serous otitis media
33.6
69.9
45
14
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.6
68.1
141
284
TDA90
NOMESCO Finland
Removal wax from ear
13.0
67.3
66
54
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
66.4
63
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
61.1
58
*
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
58.9
56
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.1
58.8
109
197
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
55.8
53
*
H60.8
ICD-10 Finland
Other otitis externa
8.1
54.1
75
99
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
52.6
50
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
52.6
50
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
16.4
51.5
44
28
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.9
50.9
358
1644
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.7
46.0
116
274
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
6.8
44.5
72
113
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
43.0
41
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
43.0
41
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.2
42.9
200
722
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
149.7
41.1
43
*
DEB30
NOMESCO Finland
Radical mastoidectomy
413.8
40.4
40
*
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
3.7
39.6
137
408
4141
FHL
Myringoplasty (also for reasons other than inflammation)
402.9
39.4
39
*
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
392.0
38.3
38
*
4151
FHL
Reoperation for chronic otitis media
+∞
37.7
36
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
36.7
35
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
36.7
35
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
35.3
141
460
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.7
35.2
68
127
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
35.1
553
3532
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
81.2
35.1
39
5
R5120
NOMESCO Finland
Preparation of an aid
5.1
34.9
77
162
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
34.6
33
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
7.5
34.2
50
70
DFF15
NOMESCO Finland
Speech audiometry
4.1
33.9
101
270
4122
FHL
Tympanostomy (tympanic tube)
+∞
33.5
32
*
DAX08
NOMESCO Finland
Fitting of hearing aid
3.7
31.4
105
304
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
30.4
29
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
30.4
29
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
159.9
29.8
31
*
H70.0
ICD-10 Finland
Acute mastoiditis
+∞
29.3
28
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
29.3
28
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
28.3
27
*
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
26.2
25
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
138.7
25.7
27
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
22.6
24.5
35
16
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
24.1
23
*
H04
ICPC
Ear discharge
4.4
23.1
59
140
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
23.0
22
*
DEB00
NOMESCO Finland
Cortical mastoidectomy
235.3
22.7
23
*
H92.0
ICD-10 Finland
Otalgia
3.7
22.3
73
208
H61.2
ICD-10 Finland
Impacted cerumen
3.1
21.5
97
338
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
20.9
20
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
20.0
142
626
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
203.9
19.6
20
*
H60
ICD-10 Finland
Otitis externa
3.5
19.5
69
207
R01AD08
ATC
fluticasone; nasal
2.0
19.2
275
1605
J01DA06
ATC
[U] cefuroxime
2.3
19.0
168
816
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
18.8
18
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.0
18.4
84
294
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
96.8
17.6
19
*
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
183.2
17.6
18
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.6
17.5
59
171
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
3.7
17.5
56
157
J01DA01
ATC
[U] cefalexin
1.8
16.8
611
4705
H92.1
ICD-10 Finland
Otorrhoea
+∞
16.7
16
*
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
16.7
16
*
J01MA02
ATC
ciprofloxacin; systemic
1.8
16.5
415
2869
H60.4
ICD-10 Finland
Cholesteatoma of external ear
30.6
16.2
21
7
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
15.8
270
1656
J01FF01
ATC
clindamycin; systemic
1.8
15.4
277
1724
J01DC02
ATC
cefuroxime; systemic
3.0
14.9
66
227
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
15.3
14.9
24
16
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
12.7
14.9
26
21
3831A
ICD-9 Finland
Mastoiditis and related conditions, Chronic mastoiditis
+∞
14.6
14
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
14.6
14
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
14.6
14
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
152.2
14.5
15
*
H01
ICPC
Ear pain/earache
2.3
14.0
107
486
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
5.0
13.9
30
62
J01CA04
ATC
amoxicillin; systemic
1.8
13.6
760
6410
RK320, ,
NOMESCO Finland
11.7
13.3
24
21
H02AB06
ATC
prednisolone; systemic
1.7
13.1
462
3436
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
28.8
13.0
17
6
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.6
12.7
43
125
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.6
12.6
42
121
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
70.8
12.6
14
*
H02AB04
ATC
methylprednisolone; systemic
2.0
12.4
151
821
4451
FHL
Guitar cutting
9.1
12.3
25
28
RK520, ,
NOMESCO Finland
19.2
11.6
17
9
4143
FHL
Atticotomy or atticoanthromy through the ear canal
+∞
11.5
11
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
11.5
11
*
DC1BD
NOMESCO Finland
Temporal bone extensive CT
+∞
11.5
11
*
H70.9
ICD-10 Finland
Mastoiditis, unspecified
+∞
11.5
11
*
J01FA10
ATC
azithromycin; systemic
1.6
11.4
483
3715
RK420, ,
NOMESCO Finland
43.8
10.9
13
*
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
9.7
10.8
21
22
J33.8
ICD-10 Finland
Other polyp of sinus
3.8
10.8
33
90
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
5.3
10.6
21
40
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.8
10.5
53
197
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
111.2
10.4
11
*
38310
ICD-8 Finland
Mastoiditis without mention of otitis media, Chronic
+∞
10.4
10
*
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
10.4
10
*
J01DB01
ATC
cefalexin; oral
1.7
10.1
763
6628
J01MA12
ATC
levofloxacin; systemic
1.7
10.0
198
1249
J01DA08
ATC
[U] cefaclor
2.2
10.0
88
423
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
10.0
458
3547
J32.4
ICD-10 Finland
Chronic pansinusitis
4.8
9.8
22
47
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
7.5
9.7
22
30
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
9.7
81
381
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.3
9.6
71
317
4146
FHL
Radical cutting (bridge broken)
+∞
9.4
9
*
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
9.4
9
*
4224
FHL
Endonasal anthrostomy
5.2
9.4
19
37
RK110, ,
NOMESCO Finland
9.1
9.0
18
20
EMB30
NOMESCO Finland
Adenotomy
15.8
9.0
14
9
J01FA09
ATC
clarithromycin; systemic
1.6
9.0
264
1838
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
9.0
619
5181
Z98.8
ICD-10 Finland
Other specified postsurgical states
4.9
8.9
19
39
1450
FHL
Otomicroscopy
27.8
8.5
11
*
S02CA03
ATC
hydrocortisone and antiinfectives; otic
90.8
8.4
9
*
38799
ICD-8 Finland
Other disease of ear and mastoid process, Other
90.8
8.4
9
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
8.4
254
1778
H02AB07
ATC
prednisone; oral
1.8
8.4
138
824
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
4.9
8.4
18
37
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
8.3
8
*
50499
ICD-8 Finland
Deflected nasal septum
3.7
8.3
26
72
J01DA09
ATC
[U] cefadroxil
1.6
8.2
239
1656
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
8.0
175
1129
N07CA01
ATC
betahistine; oral
2.1
8.0
81
412
RK120, ,
NOMESCO Finland
15.2
7.7
12
8
H29
ICPC
Ear symptom/complaint other
1.9
7.7
107
607
D07AC01
ATC
betamethasone; topical
1.5
7.7
327
2459
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.7
273
1977
50300
ICD-8 Finland
Chronic sinusitis, Maxillaris cum empyemate
7.2
7.5
17
24
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
7.5
99
552
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
7.5
272
1978
H60.0
ICD-10 Finland
Abscess of external ear
11.0
7.3
13
12
DC1AA
NOMESCO Finland
Temporalbone X-ray examination
+∞
7.3
7
*
38200
ICD-8 Finland
Acute / Acute otitis media with mastoiditis
+∞
7.3
7
*
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
30.2
7.2
9
*
A02BC01
ATC
omeprazole; systemic
1.5
7.1
263
1915
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
7.1
54
245
J01DC04
ATC
cefaclor; oral
4.4
7.0
17
39
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
3.2
6.9
26
82
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
6.8
302
2280
H71
ICPC
Acute otitis media/myringitis
6.2
6.8
17
28
H60.2
ICD-10 Finland
Malignant otitis externa
40.3
6.8
8
*
T16
ICD-10 Finland
Foreign body in ear
5.9
6.6
17
29
J47
ICD-10 Finland
Bronchiectasis
3.2
6.6
25
79
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
3.4
6.6
23
69
R03DC03
ATC
montelukast; oral
1.7
6.5
135
859
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.9
6.4
82
452
R01AD09
ATC
mometasone; nasal
1.4
6.4
363
2861
RK290, ,
NOMESCO Finland
14.4
6.4
10
7
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.4
179
1225
H61.8
ICD-10 Finland
Other specified disorders of external ear
5.2
6.3
18
35
S02AA03
ATC
boric acid; otic
5.6
6.3
17
31
ZXC10
NOMESCO Finland
Use of laser
3.0
6.3
27
92
ZXD05
NOMESCO Finland
Urgent procedure
1.5
6.3
279
2100
4148
FHL
Radical cutting and cavity filling
+∞
6.3
6
*
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
+∞
6.3
6
*
ZXA05
NOMESCO Finland
Left side
1.5
6.2
235
1716
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.6
6.2
164
1108
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
2.3
6.1
44
195
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.1
6.1
53
254
G47.3
ICD-10 Finland
Sleep apnoea
1.5
6.1
198
1397
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.6
6.1
19
53
WX722
NOMESCO Finland
PEEP
2.2
6.1
51
242

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
256
912
3.44
57.54
2.8
1.7
—
—
—
0
0
178
928
2.12
16.70
1.8
1.4
—
—
—
0
0
206
1193
1.92
14.23
2.1
2.0
—
—
—
0
0
143
798
1.93
10.86
3.0
4.2
—
—
—
0
0
106
543
2.07
10.24
3.2
3.8
7.42
7.40
ph
0.37
13
61
106
551
2.04
9.84
3.2
3.7
5.19
5.18
kpa
0.03
101
529
463
3706
1.47
8.02
7.3
5.8
26.05
26.78
%
0.78
435
3472
439
3506
1.46
7.54
7.3
5.6
0.69
0.66
%
0.72
409
3271
452
3630
1.45
7.54
7.5
5.9
8.81
8.80
%
0.02
424
3396
78
403
2.02
7.37
3.3
3.9
—
—
—
0
0
448
3609
1.44
7.26
7.2
5.6
3.01
2.89
%
0.48
421
3374
451
3643
1.44
7.18
7.1
5.5
58.32
57.99
%
0.24
426
3416
321
2468
1.45
6.51
2.7
2.6
50.38
92.84
u/l
0.72
299
2295
651
5723
1.41
5.87
4.8
4.1
14.30
13.09
mm/h
1.16
609
5244
315
2452
1.42
5.86
4.8
4.1
—
—
—
0
0
445
3677
1.38
5.81
6.4
6.1
1.22
1.21
mmol/l
2.18
397
3321
571
4920
1.38
5.74
3.4
3.2
57.78
51.52
u/l
0.57
529
4552
305
2378
1.41
5.57
4.8
4.3
—
—
—
0
0
376
3040
1.38
5.53
2.4
2.2
—
—
—
0
0
434
3593
1.37
5.51
7.5
6.0
—
—
—
0
0
85
500
1.77
5.44
3.9
3.0
4.17
7.11
e9/l
1.31
58
391
472
3984
1.36
5.20
19.3
17.3
1.32
1.32
inr
0.01
137
1142
544
4713
1.35
4.95
6.0
5.0
7.03
6.78
mmol/l
1.47
517
4436
474
4025
1.34
4.92
6.4
6.8
1.22
1.21
mmol/l
1.64
391
3410
153
1073
1.50
4.83
1.4
1.2
—
—
—
0
0
19
63
3.06
4.69
1.9
1.3
0.42
0.41
g/l
0.02
12
47
19
63
3.06
4.69
1.9
1.3
2.88
2.70
g/l
0.18
12
47
19
63
3.06
4.69
1.9
1.3
6.99
7.66
g/l
0.29
12
47
27
110
2.50
4.58
2.1
1.6
0.72
0.78
g/l
0.11
17
88
390
3243
1.34
4.56
4.5
3.9
38.67
55.21
ng/l
0.79
296
2394
322
2605
1.35
4.52
3.4
3.1
1946.20
1623.29
ng/l
0.66
278
2239
459
3912
1.33
4.51
6.9
5.6
1.78
1.89
e9/l
1.33
415
3451
19
65
2.96
4.46
1.9
1.2
—
—
—
0
0
113
755
1.56
4.45
3.6
3.0
205.10
227.44
ng/l
0.25
102
691
272
2151
1.37
4.40
2.4
2.1
3.03
3.08
mg/l
0.10
226
1814
450
3836
1.32
4.37
6.9
5.5
0.04
0.04
e9/l
1.39
395
3308
635
5682
1.33
4.36
4.2
3.8
15.05
14.92
pmol/l
0.63
559
5095
447
3825
1.31
4.16
6.9
5.5
0.62
0.60
e9/l
1.01
393
3295
461
3964
1.31
4.13
7.1
5.7
0.21
0.20
e9/l
1.16
410
3469
217
1676
1.38
4.03
1.8
1.8
1103.51
1191.31
nmol/l
0.62
154
1244
669
6062
1.32
4.03
8.3
7.6
79.65
79.60
u/l
0.01
624
5681
607
5427
1.31
4.02
5.3
4.5
—
—
—
0
0
245
1932
1.36
3.99
2.9
2.4
—
—
—
0
0
30
137
2.23
3.99
2.4
2.7
—
—
—
0
0
302
2464
1.33
3.90
2.3
2.2
166.94
247.43
u/l
1.47
286
2321
20
77
2.63
3.82
3.7
3.2
—
—
—
0
0
310
2546
1.32
3.81
2.9
2.5
—
—
—
0
0
297
2425
1.32
3.80
3.5
3.3
300.32
316.43
mg/l
0.02
189
1589
584
5223
1.29
3.72
5.4
4.8
112.38
3141.93
e6/l
—
8
94
399
3410
1.29
3.59
2.2
2.1
96.97
93.82
pmol/l
0.51
201
1778
412
3544
1.28
3.50
4.4
4.8
34.19
35.07
g/l
2.29
383
3280
72
461
1.61
3.43
7.9
10.2
—
—
—
0
0
98
675
1.50
3.39
1.3
1.4
—
—
—
0
0
31
154
2.05
3.38
1.4
1.3
72.29
64.37
mmol/l
0.47
21
130
305
2537
1.29
3.34
3.8
3.2
7.06
7.47
mmol/l
0.89
232
2109
308
2579
1.28
3.18
4.2
3.9
9.89
8.63
mg/mmol
0.19
178
1657
762
7127
1.31
3.07
6.8
6.1
41.61
40.42
mmol/mol
2.59
685
6558
145
1096
1.38
3.05
5.3
5.6
1.03
1.03
mmol/l
0.04
128
1006
473
4188
1.25
3.01
6.0
6.3
10.59
11.99
umol/l
3.08
457
3975
28
141
2.01
2.97
3.1
2.9
4.28
4.36
e9/l
0.06
28
141
107
774
1.43
2.91
1.9
2.3
0.20
0.20
g/l
0.02
95
713
177
1392
1.33
2.89
1.6
1.4
2.64
2.59
g/l
0.13
101
843
40
230
1.77
2.87
4.3
3.1
—
—
—
0
0
577
6282
0.80
2.86
24.7
20.6
331.46
332.14
g/l
0.88
572
6238
167
1304
1.34
2.86
3.0
3.3
0.80
0.82
mmol/l
1.23
158
1224
203
1635
1.30
2.79
4.9
3.9
159.11
273.35
ng/l
0.99
167
1332
417
3663
1.24
2.78
3.1
2.6
—
—
—
0
0
207
1680
1.29
2.69
1.6
1.7
1.30
1.35
mg/l
0.10
154
1297
28
147
1.93
2.67
3.7
3.2
59.75
58.76
%
0.14
28
147
30
162
1.88
2.64
3.9
3.9
—
—
—
0
0
7
15
4.69
2.60
1.0
1.2
—
—
—
0
0
166
1315
1.32
2.57
3.3
2.5
12.05
12.77
umol/l
0.58
157
1225
241
2004
1.27
2.57
4.2
4.1
87.98
86.83
%
0.26
231
1952
5
7
7.17
2.55
1.0
1.0
—
—
—
0
0
743
6981
1.26
2.55
5.1
4.7
1.98
1.98
mu/l
0.01
664
6293
31
172
1.83
2.52
2.1
2.2
118.86
127.00
g/l
1.39
22
124
17
75
2.29
2.52
1.1
1.0
0.78
0.84
u/ml
—
7
36
807
7664
1.30
2.51
20.0
15.6
25.24
26.01
mg/l
0.25
690
6165
102
754
1.39
2.48
7.6
7.3
11.12
10.52
mmol/l
0.34
96
719
82
583
1.44
2.47
3.0
2.5
10.55
10.84
g/l
0.32
77
531
31
174
1.81
2.44
4.7
4.5
2.36
2.64
mmol/l
0.25
25
114
493
4449
1.22
2.43
9.3
8.9
4.29
4.22
e9/l
0.24
436
3890
51
329
1.58
2.43
4.3
3.2
81.34
59.51
u/ml
0.20
51
315
118
900
1.35
2.37
2.6
2.8
8.17
9.46
umol/l
0.38
103
797
207
1706
1.27
2.37
3.2
3.0
522.46
551.56
mosm/kgh2o
1.22
175
1461
18
87
2.09
2.18
2.4
1.5
—
—
—
0
0
38
237
1.63
2.10
1.3
1.6
—
—
—
0
0
150
1208
1.29
2.07
3.4
2.5
2.30
2.29
g/l
0.05
142
1124
65
459
1.45
2.06
2.3
1.8
0.93
1.53
g/l
2.70
60
422
18
89
2.04
2.06
1.1
1.1
0.21
1.63
u/ml
—
9
50
92
691
1.37
2.06
2.7
2.1
403.99
378.04
nmol/l
0.38
80
631
23
125
1.86
2.04
2.5
2.6
—
—
—
0
0
373
3321
1.20
2.01
3.3
2.8
142.66
143.55
ug/l
0.02
326
3018
51
346
1.50
1.98
1.4
1.2
—
—
—
0
0
12
51
2.37
1.95
1.5
2.8
7.43
7.41
ph
—
5
13
12
51
2.37
1.95
1.2
1.8
42.27
35.67
%
0.79
12
51
42
274
1.56
1.95
3.4
5.7
1.26
1.35
mmol/l
0.25
36
244
14
65
2.17
1.88
1.1
1.1
—
—
—
0
0
754
7179
1.22
1.84
4.4
4.1
1.36
1.28
mmol/l
2.07
664
6476
75
557
1.38
1.82
1.5
1.5
—
—
—
0
0
140
1139
1.27
1.79
3.5
2.5
20.10
22.70
%
1.36
121
975
34
216
1.59
1.78
2.2
2.1
11.71
12.22
mg/l
0.17
28
192
35
224
1.58
1.78
4.1
2.9
24.68
24.85
mmol/l
0.09
35
219
125
1004
1.28
1.78
1.2
1.3
—
—
—
0
0
6
18
3.35
1.75
1.3
2.1
137.83
129.56
nmol/l
—
6
18
239
2069
1.20
1.72
2.8
2.8
2992.33
8198.33
umol/l
1.66
206
1781
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
18
96
1.89
1.71
2.1
2.8
—
—
—
0
0
146
1758
0.80
1.71
3.6
3.9
—
—
—
0
0
26
156
1.68
1.70
3.4
2.6
—
—
—
0
0
20
111
1.82
1.69
1.2
1.4
—
—
—
0
0
57
410
1.41
1.68
2.8
2.5
—
—
—
0
0
6
19
3.17
1.66
2.7
1.7
60.17
90.53
nmol/24h
—
6
19
289
2554
1.19
1.65
4.1
3.3
—
—
—
0
0
120
971
1.27
1.62
1.3
1.3
595.00
402.68
titre
0.39
24
209
210
1808
1.21
1.60
1.7
1.7
406.38
19073997.64
pmol/l
1.55
169
1468
6
20
3.01
1.58
1.0
1.0
—
12.80
—
0
15
141
1689
0.81
1.58
3.6
4.3
1.02
1.02
kg/l
0.56
29
225
283
2508
1.18
1.56
3.3
3.3
31.40
35.68
u/l
1.55
263
2380
50
687
0.71
1.54
2.5
3.5
—
—
—
0
0
7
27
2.60
1.51
3.0
2.6
43014.29
36485.37
ug/l
—
7
27
0
44
0.00
1.51
0.0
1.6
—
45.76
—
0
5
80
620
1.32
1.51
4.4
4.1
0.03
0.11
%
1.18
30
209
84
659
1.30
1.46
4.4
4.0
0.97
0.90
%
0.13
34
246
237
2080
1.18
1.46
1.7
1.6
18.14
20.36
nmol/l
1.57
194
1749
15
80
1.89
1.45
1.0
1.1
0.47
0.79
u/ml
—
5
34
346
3136
1.16
1.42
2.2
2.3
79.40
77.77
nmol/l
0.44
290
2745
17
96
1.78
1.39
1.6
3.9
—
—
—
0
0
6
23
2.62
1.37
1.0
1.0
—
—
—
0
0
771
7422
1.18
1.35
4.8
4.5
1.38
1.44
mmol/l
3.16
680
6747
22
136
1.63
1.33
1.0
1.2
—
—
—
0
0
12
61
1.98
1.33
1.1
1.1
—
—
—
0
0
75
590
1.29
1.30
4.7
3.9
0.52
0.63
%
0.25
31
206
16
91
1.77
1.29
2.1
2.0
—
—
—
0
0
16
91
1.77
1.29
1.5
1.2
—
—
—
0
0
44
319
1.40
1.29
2.0
2.1
248.45
537.33
ug/l
0.96
44
299
42
302
1.41
1.29
1.8
2.0
—
—
—
0
0
5
18
2.79
1.28
1.2
1.1
—
—
—
0
0
121
1010
1.23
1.27
7.7
7.4
5.15
5.09
kpa
0.26
114
970
22
138
1.61
1.27
4.7
2.6
—
—
—
0
0
121
1011
1.22
1.26
7.7
7.4
11.93
11.95
kpa
0.01
114
973
121
1012
1.22
1.25
7.7
7.5
1.47
1.24
mmol/l
0.30
97
796
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
820
7952
1.19
1.23
23.2
18.5
139.49
139.62
mmol/l
0.74
800
7741
10
49
2.05
1.22
1.3
1.9
4.20
5.51
umol/l
—
5
35
5
19
2.64
1.21
1.4
1.9
—
—
—
0
0
821
7965
1.19
1.21
23.3
18.6
3.99
3.99
mmol/l
0.05
800
7743
833
8092
1.19
1.20
12.4
10.7
26.08
25.97
u/l
0.06
803
7778
59
455
1.32
1.19
1.2
1.2
—
—
—
0
0
21
133
1.59
1.18
3.0
2.1
—
—
—
0
0
10
50
2.01
1.16
2.7
2.1
—
—
—
0
0
30
207
1.46
1.16
1.4
1.1
—
—
—
0
0
0
34
0.00
1.16
0.0
7.2
—
—
—
0
0
200
1766
1.17
1.15
3.0
2.6
7.51
4.88
e6/l
0.93
174
1595
83
675
1.25
1.13
5.5
3.9
—
—
—
0
0
790
7653
1.16
1.12
5.3
5.1
2.62
2.66
mmol/l
0.66
693
6966
23
337
0.67
1.07
7.4
4.5
—
—
—
0
0
773
7485
1.15
1.06
4.9
4.6
4.45
4.54
mmol/l
1.54
692
6853
14
82
1.72
1.05
1.6
2.4
0.51
1.38
g/24h
—
7
36
14
82
1.72
1.05
1.0
1.1
1.92
7.37
u/ml
—
7
44
25
171
1.47
1.03
3.0
2.4
15.06
15.67
%
0.45
16
82
61
484
1.28
1.03
1.3
1.4
—
—
—
0
0
148
1289
1.17
1.02
2.1
2.0
29.81
29.89
s
0.07
140
1245
28
197
1.43
1.01
3.7
2.7
8.37
7.86
kpa
1.16
28
192
9
48
1.88
1.00
1.2
1.3
—
—
—
0
0
335
3094
1.13
0.99
5.0
5.2
2.19
3.30
ug/l
1.90
280
2745
9
49
1.84
0.98
1.1
1.1
—
—
—
0
0
5
23
2.18
0.98
1.2
1.7
—
—
—
0
0
66
533
1.26
0.97
1.2
1.2
—
—
—
0
0
767
7438
1.14
0.97
5.1
4.8
6.11
6.01
mmol/l
1.11
682
6703
9
50
1.81
0.96
1.3
1.5
82.11
85.12
umol/l
—
9
50
71
580
1.24
0.95
4.9
4.1
0.04
0.07
%
0.20
23
167
0
32
0.00
0.95
0.0
1.3
—
6.63
—
0
32
16
245
0.65
0.94
5.3
4.8
—
—
—
0
0
51
401
1.29
0.94
3.4
3.2
4.53
4.48
pmol/l
0.11
41
346
85
711
1.21
0.92
2.0
2.8
66.83
66.18
g/l
0.33
79
643
816
7956
1.15
0.91
18.2
14.8
—
—
—
0
0
529
5543
0.90
0.89
4.6
4.1
—
—
—
0
0
8
42
1.91
0.88
1.1
1.0
—
—
—
0
0
89
752
1.20
0.88
3.0
2.6
67.95
68.76
e9/l
0.07
62
592
175
1564
1.14
0.87
1.3
1.2
4.11
1.58
u/ml
0.48
36
415
41
318
1.30
0.85
2.5
2.9
0.63
0.28
g/l
0.49
12
125
101
867
1.18
0.84
1.5
1.6
—
—
—
0
0
8
45
1.78
0.84
1.3
13.0
—
—
—
0
0
83
701
1.20
0.83
1.6
1.4
—
—
—
0
0
0
26
0.00
0.78
0.0
1.0
—
—
—
0
0
0
27
0.00
0.77
0.0
2.0
—
—
—
0
0
12
75
1.61
0.75
1.7
1.3
7591.50
142768.67
e6/l
—
6
51
9
54
1.67
0.74
1.1
1.1
—
—
—
0
0
232
2517
0.90
0.74
2.9
3.0
—
—
—
0
0
7
38
1.85
0.73
1.0
1.0
—
—
—
0
0
9
55
1.64
0.73
3.0
2.4
—
—
—
0
0
45
362
1.25
0.73
1.8
1.8
1.26
2.25
ug/l
0.52
39
320
5
25
2.00
0.72
3.0
1.6
—
—
—
0
0
5
25
2.00
0.72
5.2
1.9
2.44
8.93
nmol/l
—
5
20
35
273
1.29
0.72
1.1
1.1
—
—
—
0
0
17
117
1.46
0.72
3.4
2.0
32.29
32.45
pg
0.06
17
117
21
286
0.73
0.71
2.2
1.7
—
—
—
0
0
14
93
1.51
0.69
1.0
1.1
—
—
—
0
0
17
238
0.71
0.68
1.3
1.2
—
—
—
0
0
14
94
1.50
0.67
1.0
1.1
—
—
—
0
0
13
86
1.52
0.66
1.2
1.2
—
66.45
—
0
6
5
29
1.73
0.64
1.0
1.1
105.30
129.64
iu/ml
—
5
29
10
63
1.59
0.62
1.0
1.2
—
—
—
0
0
81
705
1.16
0.61
10.4
8.8
—
—
—
0
0
25
192
1.31
0.59
1.5
1.6
42852.39
15192.56
e6/l
0.35
18
138
8
52
1.54
0.59
1.5
1.9
16.38
19.37
nmol/l
—
8
45
72
624
1.17
0.58
3.8
3.8
92.77
89.15
ng/l
0.16
56
545
257
2406
1.09
0.58
4.9
4.0
7.41
7.40
ph
2.44
55
452
20
149
1.35
0.58
1.4
1.5
—
—
—
0
0
39
319
1.23
0.58
1.2
1.1
—
86.38
—
0
8
58
495
1.18
0.56
4.4
3.4
—
—
—
0
0
17
124
1.38
0.56
1.3
1.4
—
—
—
0
0
857
8441
1.12
0.55
28.7
23.0
39.47
39.88
%
1.09
791
7827
6
37
1.63
0.55
3.5
2.4
419.67
917.19
u/ml
—
6
37
24
186
1.30
0.54
2.8
2.6
—
—
—
0
0
9
60
1.50
0.54
1.1
1.2
—
—
—
0
0
223
2082
1.09
0.54
3.9
3.5
—
—
—
0
0
857
8444
1.12
0.54
28.5
22.8
91.31
91.33
fl
0.04
844
8296
857
8445
1.12
0.53
28.4
22.7
30.35
30.38
pg
0.14
844
8294
217
2025
1.09
0.53
1.7
1.6
1.44
1.35
mmol/l
0.74
177
1669
857
8446
1.11
0.53
28.5
22.8
4.41
4.46
e12/l
2.27
837
8196
857
8446
1.11
0.53
28.6
22.8
6.93
6.83
e9/l
0.72
833
8195
19
248
0.76
0.52
8.7
9.8
—
—
—
0
0
84
745
1.14
0.51
1.5
1.6
—
—
—
0
0
857
8448
1.11
0.51
28.7
23.0
132.80
134.51
g/l
2.65
844
8296
6
41
1.47
0.50
1.0
1.2
—
—
—
0
0
26
209
1.25
0.47
1.3
1.2
—
555.00
titre
—
0
6
233
2196
1.08
0.46
4.1
3.2
—
—
—
0
0
7
49
1.43
0.46
1.0
1.2
136.14
151.02
nmol/l
—
7
49
292
2777
1.07
0.45
3.2
3.4
2.34
2.35
mmol/l
0.21
248
2423
183
1957
0.92
0.45
1.3
1.4
—
—
—
0
0
7
50
1.40
0.45
5.3
3.1
—
—
—
0
0
7
50
1.40
0.45
1.4
1.7
—
—
—
0
0
855
8442
1.10
0.43
28.6
22.8
245.87
243.38
e9/l
0.51
836
8217
83
746
1.12
0.43
3.1
2.5
30.35
33.63
u/l
0.64
68
627
67
594
1.14
0.43
1.7
2.6
—
—
—
0
0
197
2095
0.93
0.43
4.3
4.1
0.00
0.00
estimate
0.50
84
697
5
31
1.62
0.43
1.2
1.2
217.00
178.28
mmol/24h
—
5
31
5
31
1.62
0.43
4.2
3.1
—
—
—
0
0
369
3838
0.94
0.43
4.1
3.9
0.00
0.00
estimate
0.50
81
706
190
1782
1.08
0.43
3.2
3.2
0.97
0.79
ug/l
0.81
121
1207
5
32
1.57
0.42
1.8
1.4
—
—
—
0
0
5
32
1.57
0.42
1.2
1.1
16.00
25.71
%
—
5
26
10
139
0.72
0.42
1.2
1.2
32.21
36.90
u/l
—
10
120
49
561
0.87
0.41
1.4
1.4
—
—
—
0
0
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
365
3788
0.94
0.39
5.5
5.2
0.00
0.00
estimate
-0.00
85
726
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
148
1584
0.92
0.38
2.8
3.1
2.46
2.45
mmol/l
0.28
128
1394
5
37
1.35
0.37
1.0
1.4
1.23
1.54
g/l
—
5
37
9
71
1.27
0.36
1.0
1.1
—
—
—
0
0
6
42
1.43
0.35
1.0
1.4
—
—
—
0
0
263
2516
1.06
0.35
4.0
3.4
68.98
99.05
e6/l
0.27
210
1973
110
1019
1.09
0.34
2.3
2.5
1.86
1.78
%
0.29
90
908
17
136
1.25
0.33
1.4
1.2
245.00
288.78
u/ml
0.30
12
77
56
622
0.89
0.32
2.2
2.2
11.78
12.89
nmol/l
0.39
48
554
25
212
1.18
0.30
4.7
4.5
—
—
—
0
0
33
288
1.15
0.29
3.8
4.0
42.27
76.13
mg/l
0.85
27
233
8
62
1.29
0.28
1.5
1.0
—
—
—
0
0
8
64
1.25
0.27
1.3
1.6
—
—
—
0
0
8
66
1.21
0.26
1.4
1.8
—
—
—
0
0
14
113
1.24
0.26
1.4
1.1
—
—
—
0
0
86
800
1.08
0.26
1.8
2.2
219.90
145.16
ug/g
0.42
64
632
31
272
1.14
0.26
1.7
1.9
21.31
22.12
s
0.40
26
247
5
74
0.67
0.26
1.4
1.2
—
—
—
0
0
91
850
1.08
0.25
1.3
1.3
—
—
—
0
0
22
188
1.17
0.25
4.7
3.7
72.22
30.71
mg/l
—
9
124
24
208
1.16
0.24
1.3
1.2
—
—
—
0
0
128
1215
1.06
0.23
1.4
1.3
17.71
34.60
iu/ml
4.36
35
384
112
1059
1.07
0.23
1.8
1.7
—
—
—
0
0
7
92
0.76
0.22
1.1
1.3
—
—
—
0
0
199
1916
1.05
0.22
7.9
6.7
—
—
—
0
0
237
2292
1.04
0.22
4.1
3.2
0.32
0.54
e6/l
2.08
190
1773
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
257.60
—
0
5
0
10
0.00
0.21
0.0
1.1
—
333.16
—
0
5
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
7.2
—
—
—
0
0
26
230
1.13
0.20
1.4
1.4
369.22
283.19
ug/g
—
9
134
39
428
0.91
0.20
1.8
1.6
—
—
—
0
0
372
3803
0.96
0.20
4.0
3.9
0.00
0.00
estimate
0.75
94
779
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
82
772
1.07
0.20
2.0
2.6
4.56
6.43
ug/l
1.05
70
682
16
136
1.18
0.20
1.1
1.2
—
—
—
0
0
17
146
1.17
0.19
8.9
2.0
—
—
—
0
0
32
289
1.11
0.19
3.8
4.0
47.70
49.60
mg/l
0.04
26
235
6
52
1.15
0.19
1.0
1.6
0.87
0.99
g/l
—
6
52
16
137
1.17
0.19
3.7
2.4
3063.27
2861.13
u/l
—
6
50
138
1324
1.05
0.18
3.5
3.1
1.87
2.16
e6/l
0.28
73
767
91
863
1.06
0.18
3.1
4.2
13.78
26.39
ug/l
0.50
70
726
7
60
1.17
0.18
1.1
1.1
—
3.31
—
0
13
17
195
0.87
0.17
1.1
1.2
—
—
—
0
0
11
91
1.21
0.17
13.1
2.5
—
—
—
0
0
16
138
1.16
0.17
1.6
1.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.5
—
—
—
0
0
296
2892
1.03
0.17
4.5
3.8
105.14
115.57
e6/l
0.10
219
2102
5
67
0.75
0.17
2.2
2.1
6.78
4.03
mg/l
—
5
62
646
6529
0.97
0.17
22.9
18.6
15.94
15.12
%
2.21
635
6422
17
194
0.87
0.16
1.6
1.6
—
—
—
0
0
10
120
0.83
0.16
2.8
2.9
—
—
—
0
0
41
441
0.93
0.15
1.2
1.2
91.57
146.44
iu/ml
0.83
17
173
9
79
1.14
0.15
1.0
1.1
—
—
—
0
0
16
140
1.15
0.15
1.6
1.6
—
—
—
0
0
30
326
0.92
0.14
2.5
3.3
28.00
11902.28
u/ml
0.79
23
277
136
1405
0.96
0.14
3.6
2.9
1.56
1.15
e6/l
0.42
72
839
120
1160
1.04
0.13
1.4
1.3
8.31
8.82
u/ml
0.05
34
415
9
107
0.84
0.13
1.3
1.2
—
—
—
0
0
17
189
0.90
0.12
2.1
2.4
—
—
—
0
0
17
189
0.90
0.12
3.4
1.9
—
—
—
0
0
24
220
1.09
0.12
2.8
2.3
111.59
79.76
ug/min
0.30
17
126
54
568
0.95
0.11
6.0
6.3
25.32
24.37
mmol/l
1.26
49
541
18
199
0.90
0.11
2.9
3.3
1.72
1.58
mmol/l
0.21
18
194
19
172
1.11
0.11
1.4
1.6
2.43
5.59
iu/l
—
8
50
71
681
1.05
0.11
6.1
3.7
1.23
1.22
mmol/l
0.13
59
585
74
770
0.96
0.11
1.7
1.6
—
—
—
0
0
30
281
1.07
0.09
4.0
4.0
1.67
1.82
ratio
—
7
28
10
87
1.15
0.09
1.3
1.3
—
—
—
0
0
39
411
0.95
0.09
3.7
4.0
—
—
—
0
0
44
419
1.05
0.09
1.3
1.2
—
—
—
0
0
12
107
1.12
0.08
2.5
1.8
85.70
89.78
%
0.45
12
107
10
113
0.88
0.08
1.1
1.0
—
—
—
0
0
22
236
0.93
0.08
1.0
1.1
—
—
—
0
0
14
154
0.91
0.08
1.4
1.6
—
—
—
0
0
7
65
1.08
0.08
1.0
1.3
—
—
—
0
0
21
195
1.08
0.08
1.1
1.1
—
—
—
0
0
34
358
0.95
0.08
1.3
1.4
—
—
—
0
0
7
67
1.05
0.08
2.7
1.7
12.41
10.50
%
—
7
67
6
70
0.86
0.07
2.3
2.4
—
—
—
0
0
7
81
0.86
0.07
1.0
2.6
—
—
—
0
0
9
85
1.06
0.07
1.3
1.4
—
—
nmol/l
—
0
0
301
3043
0.98
0.07
3.3
3.6
6.07
5.84
ph
0.55
15
196
23
216
1.07
0.07
3.7
3.3
0.73
0.84
nmol/l
0.62
18
174
8
94
0.85
0.06
1.0
1.4
—
—
—
0
0
13
141
0.92
0.05
1.2
1.3
—
—
—
0
0
340
3423
0.99
0.04
13.7
9.6
0.00
0.00
e9/l
1.04
290
2809
10
91
1.10
0.04
1.2
1.2
—
—
—
0
0
40
388
1.03
0.04
3.5
2.8
—
—
—
0
0
11
118
0.93
0.02
1.2
1.1
—
—
—
0
0
13
122
1.07
0.02
17.0
3.0
—
—
—
0
0
61
600
1.02
0.02
4.1
4.3
—
—
—
0
0
56
552
1.02
0.01
1.6
1.4
—
—
—
0
0
18
174
1.04
0.00
8.8
2.2
—
—
—
0
0
27
266
1.02
0.00
1.3
1.2
—
1.47
—
0
21
19
188
1.01
0.00
8.4
2.1
—
—
—
0
0
12
123
0.98
0.00
1.4
1.2
—
—
—
0
0
19
187
1.02
0.00
8.3
2.1
—
—
—
0
0
79
789
1.00
0.00
3.6
3.6
1.89
2.02
mmol/l
0.13
72
647
16
161
0.99
0.00
1.4
1.3
151.16
244.58
miu/ml
—
6
67
11
111
0.99
0.00
1.7
1.6
—
—
—
0
0
16
159
1.01
0.00
1.1
1.3
—
—
—
0
0
11
105
1.05
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.7
—
0.36
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
6.75
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
-0.00
1.5
1.3
—
—
—
0
0
8
81
0.99
-0.00
1.5
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
8
84
0.95
-0.00
1.1
1.1
—
—
—
0
0
7
77
0.91
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
8
80
1.00
-0.00
1.5
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
19
190
1.00
-0.00
8.5
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_MASTCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H8_MASTCHRON 1.062 [0.92, 1.23] 0.423
Birth year 0.993 [0.98, 1.0] 0.116

During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 1336 females with H8_MASTCHRON died.

Males

Parameter HR [95% CI] p-value
H8_MASTCHRON 1.065 [0.91, 1.24] 0.417
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 353 out of 1435 males with H8_MASTCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H8_MASTCHRON.

N-year risk Females Males
1 0.084% 0.166%
5 0.55% 1.315%
10 1.418% 3.106%
15 2.849% 5.996%
20 5.255% 10.158%

Relationships between endpoints

Index endpoint: H8_MASTCHRON – Chronic mastoiditis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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