Risteys · M13_SYNOTENDINOTH

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M68, M71.8, M71.9 Cause of death:* ICD-10 — M68*, M71.8, M71.9 2 out of 7 registries used, show all original rules.	774
4. Check minimum number of events None	774
5. Include endpoints None	774
6. Filter based on genotype QC (FinnGen only)	774

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	5589	2480	3087
Only index persons	5300	2380	2920
Unadjusted period prevalence (%)
Whole population	0.08	0.07	0.09
Only index persons	0.10	0.09	0.11
Median age at first event (years)
Whole population	53.03	54.84	51.54
Only index persons	52.30	54.19	50.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	774	364	410
Unadjusted period prevalence (%)	0.15	0.12	0.18
Median age at first event (years)	53.54	53.45	53.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
687: Matched controls
6870

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M71.9

ICD-10 Finland

Bursopathy, unspecified

2627.0

323.0

558

M71.8

ICD-10 Finland

Other specified bursopathies

+∞

124.9

116

M79.6

ICD-10 Finland

Pain in limb

4.3

57.2

271

908

M75.1

ICD-10 Finland

Rotator cuff syndrome

5.2

50.9

180

440

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

75.1

43.6

M70.2

ICD-10 Finland

Olecranon bursitis

15.7

37.5

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.8

34.9

350

1870

N02AX02

ATC

tramadol; systemic, rectal

2.6

30.7

316

1671

M01AH05

ATC

etoricoxib; oral

2.6

30.5

428

2692

M25.5

ICD-10 Finland

Pain in joint

2.9

29.6

218

935

M70.6

ICD-10 Finland

Trochanteric bursitis

4.9

27.8

219

N03AX16

ATC

pregabalin; oral

3.1

27.5

178

695

M70.4

ICD-10 Finland

Prepatellar bursitis

25.0

27.3

N03AX12

ATC

gabapentin; oral

3.8

27.1

126

382

M79.0

ICD-10 Finland

Rheumatism, unspecified

78.4

27.0

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

17.8

27.0

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

5.9

26.4

144

A46

ICD-10 Finland

Erysipelas

3.5

24.9

130

432

J01DB01

ATC

cefalexin; oral

2.8

24.8

583

4562

J01FF01

ATC

clindamycin; systemic

2.6

24.7

222

1055

M54.5

ICD-10 Finland

Low back pain

2.6

24.1

230

1129

NCM20

NOMESCO Finland

Excision of synovial ganglion of elbow or forearm

129.5

23.7

S18

ICPC

Laceration/cut

2.3

23.3

305

1754

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.1

23.2

266

N02AJ06

ATC

codeine and paracetamol; systemic

2.4

22.7

267

1450

M19.0

ICD-10 Finland

Primary arthrosis of other joints

4.7

22.6

191

M67.4

ICD-10 Finland

Ganglion

8.4

22.1

M48.0

ICD-10 Finland

Spinal stenosis

3.8

22.1

289

M71.0

ICD-10 Finland

Abscess of bursa

226.8

21.7

X59

ICD-10 Finland

Exposure to unspecified factor

2.9

21.2

145

576

L17

ICPC

Foot/toe symptom/complaint

2.6

21.1

182

834

L15

ICPC

Knee symptom/complaint

2.7

20.2

155

663

M03BX02

ATC

tizanidine; oral

2.1

20.2

425

2963

NGM20

NOMESCO Finland

Excision of synovial ganglion of knee or lower leg

59.3

20.0

M17.1

ICD-10 Finland

Other primary gonarthrosis

2.7

18.8

150

654

A02BC02

ATC

pantoprazole; systemic

2.1

18.7

432

3082

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

7.7

18.5

M01AE03

ATC

ketoprofen; systemic, rectal

2.2

18.3

259

1502

R07.4

ICD-10 Finland

Chest pain, unspecified

2.4

18.1

186

924

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.9

17.9

221

J01DA01

ATC

[U] cefalexin; systemic

2.0

17.8

427

3063

M01AB05

ATC

diclofenac; systemic, rectal

2.0

17.2

454

3357

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.6

17.0

135

583

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.9

16.9

205

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

2.9

16.9

109

415

N02BE01

ATC

paracetamol; systemic, rectal

2.3

16.7

574

4715

M71.1

ICD-10 Finland

Other infective bursitis

+∞

16.7

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

3.4

16.0

265

NDM40

NOMESCO Finland

Discission of sheath of tendon of wrist or hand

27.0

15.7

M03BC01

ATC

orphenadrine (citrate); systemic

2.3

15.2

159

791

M54.4

ICD-10 Finland

Lumbago with sciatica

2.7

15.1

111

456

WX320

NOMESCO Finland

Spinalanesthesy

2.3

15.0

166

847

X58

ICD-10 Finland

Exposure to other specified factors

2.8

14.9

105

421

M79.1

ICD-10 Finland

Myalgia

3.4

14.8

240

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

4.7

14.7

112

R06.0

ICD-10 Finland

Dyspnoea

2.3

14.7

160

810

ZXA00

NOMESCO Finland

Right side

2.2

14.6

180

965

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

3.2

14.5

278

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.1

14.5

200

1123

H02AB06

ATC

prednisolone; systemic

1.9

14.2

305

2030

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.1

14.2

181

982

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

4.5

14.1

117

L03

ICPC

Low back symptom/complaint

2.3

14.0

151

757

M79.7

ICD-10 Finland

Fibromyalgia

13.0

14.0

M01AH02

ATC

rofecoxib; oral

2.8

13.8

386

M01AE02

ATC

naproxen; oral, rectal

1.9

13.7

367

2623

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

4.3

13.6

122

L08

ICPC

Shoulder symptom/complaint

2.5

13.5

118

532

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

3.8

13.4

164

M01AH01

ATC

celecoxib; oral (coxibs)

2.4

13.4

121

557

P01BA02

ATC

hydroxychloroquine; oral

3.3

13.3

225

M01AC06

ATC

meloxicam; systemic, rectal

1.9

13.0

232

1430

NBA30

NOMESCO Finland

Exploration of joint of shoulder or upper arm, arthroscopic

13.3

13.0

M02AA07

ATC

piroxicam; topical

1.9

12.9

231

1425

SPAT1153

SPAT

Removal of sutures

2.0

12.9

216

1303

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.3

12.8

220

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.9

12.8

301

M13.9

ICD-10 Finland

Arthritis, unspecified

3.6

12.8

176

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.9

12.6

217

1320

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.0

12.5

185

1059

M01AE01

ATC

ibuprofen; systemic, rectal

2.2

12.5

600

5192

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.8

12.5

326

L28

ICPC

Limited function/disability (L)

2.5

12.0

431

XA402

NOMESCO Finland

ENMG

7.8

12.0

NB1AE

NOMESCO Finland

Shoulder ultrasound examination

13.7

12.0

B01AB05

ATC

enoxaparin; parenteral

1.9

11.9

198

1183

M20.4

ICD-10 Finland

Other hammer toe(s) (acquired)

5.5

11.8

N06AA09

ATC

amitriptyline; systemic

3.0

11.6

242

P01AB01

ATC

metronidazole; oral, rectal

1.8

11.6

248

1616

J01MA02

ATC

ciprofloxacin; systemic

1.8

11.5

250

1637

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.8

11.4

328

2351

WX408

NOMESCO Finland

General anesthesy, balanced

2.0

11.2

177

1031

M01AX05

ATC

glucosamine; oral

2.2

11.0

121

606

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.5

11.0

409

N06AX21

ATC

duloxetine; oral

2.9

11.0

251

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.9

11.0

258

M16.1

ICD-10 Finland

Other primary coxarthrosis

2.7

10.9

313

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.6

10.9

352

R03AC02

ATC

salbutamol; inhalant

1.7

10.9

320

2295

A01

ICPC

Pain general/multiple sites

3.4

10.9

166

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.6

10.8

317

ZXE10

NOMESCO Finland

More than one and less than three hours

1.8

10.7

234

1526

M76.6

ICD-10 Finland

Achilles tendinitis

5.0

10.6

M70.7

ICD-10 Finland

Other bursitis of hip

8.7

10.6

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

2.5

10.4

381

NFM20

NOMESCO Finland

Excision of bursa of hip or thigh

111.6

10.4

NDM20

NOMESCO Finland

Excision of synovial ganglion of wrist or hand

111.6

10.4

S46.0

ICD-10 Finland

Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder

3.2

10.4

183

L13

ICPC

Hip symptom/complaint

2.4

10.4

438

M01AX17

ATC

nimesulide; oral

2.0

10.4

149

837

R51.80

ICD-10 Finland

Headache

2.4

10.1

382

A07EC01

ATC

sulfasalazine; oral, rectal

3.0

10.1

211

NB1CG

NOMESCO Finland

Shoulder and humerus extensive MRI examination with high intensity magnet

14.8

10.0

NF1AA

NOMESCO Finland

Hip X-ray examination

2.9

10.0

222

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

5.6

9.9

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

4.3

9.9

R60.0

ICD-10 Finland

Localized oedema

2.6

9.8

294

M70.3

ICD-10 Finland

Other bursitis of elbow

20.4

9.8

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.7

9.7

302

2178

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

9.3

9.6

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

4.1

9.6

M03BC51

ATC

orphenadrine, combinations; systemic

1.8

9.5

176

1079

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

3.0

9.4

196

J01CA04

ATC

amoxicillin; systemic

1.7

9.3

518

4380

L10

ICPC

Elbow symptom/complaint

3.8

9.2

105

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.9

9.1

195

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

2.7

9.1

244

WX110

NOMESCO Finland

Local anesthesy

1.6

9.0

435

3512

SAA01

NOMESCO Finland

Simple examination of mouth

1.6

9.0

433

3490

J01AA02

ATC

doxycycline; systemic

1.7

9.0

495

4144

ZXA05

NOMESCO Finland

Left side

1.9

9.0

153

909

M70.5

ICD-10 Finland

Other bursitis of knee

18.9

9.0

I10

ICD-10 Finland

Essential (primary) hypertension

1.6

8.9

357

2738

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.7

8.9

269

1911

NBG10

NOMESCO Finland

Acromioplastia

14.3

8.7

WX203

NOMESCO Finland

Infraclavicular plexus blockade

6.3

8.7

N06AX11

ATC

mirtazapine; oral

1.8

8.6

194

1260

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.1

8.6

478

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

2.5

8.6

282

N06AB04

ATC

citalopram; systemic

1.9

8.6

132

758

Z01.8

ICD-10 Finland

Other specified special examinations

1.9

8.6

137

797

C03CA01

ATC

furosemide; systemic

1.8

8.5

159

975

UJF32

NOMESCO Finland

Coloscopy

1.8

8.5

159

975

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

4.4

8.4

N02AA05

ATC

oxycodone; systemic

2.2

8.4

426

M65.3

ICD-10 Finland

Trigger finger

6.3

8.4

M68.8

ICD-10 Finland

Other disorders of synovium and tendon in diseases classified elsewhere

+∞

8.3

M66.0

ICD-10 Finland

Rupture of popliteal cyst

+∞

8.3

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

8.7

8.3

M53.1

ICD-10 Finland

Cervicobrachial syndrome

2.5

8.3

263

C07AB07

ATC

bisoprolol; oral

1.6

8.3

279

2029

TPH04

NOMESCO Finland

Cathetrisation of vein

1.9

8.3

130

751

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

5.0

8.3

R01AD09

ATC

mometasone; nasal

1.6

8.2

276

2004

M65.8

ICD-10 Finland

Other synovitis and tenosynovitis

14.7

8.2

NBL00

NOMESCO Finland

Suture or reinsertation of rotator cuff of shoulder

4.4

8.2

M71.3

ICD-10 Finland

Other bursal cyst

33.8

8.1

M70.8

ICD-10 Finland

Other soft tissue disorders related to use, overuse and pressure

33.8

8.1

M79.9

ICD-10 Finland

Soft tissue disorder, unspecified

17.4

8.1

M71.5

ICD-10 Finland

Other bursitis, not elsewhere classified

22.3

8.0

R4120

NOMESCO Finland

Occupational therapy

3.1

8.0

146

N06AX16

ATC

venlafaxine; oral

2.2

7.9

420

ZXE00

NOMESCO Finland

One hour or less

1.6

7.9

242

1712

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

3.7

7.9

A02BC05

ATC

esomeprazole; systemic

1.6

7.8

244

1732

L12

ICPC

Hand/finger symptom/complaint

2.2

7.8

396

L01

ICPC

Neck symptom/complaint

2.2

7.8

387

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.9

7.8

160

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

4.7

7.8

J45.9

ICD-10 Finland

Asthma, unspecified

2.0

7.7

106

580

WX200

NOMESCO Finland

Interscalenous plexus blockade

6.0

7.7

NHL16

NOMESCO Finland

Tenolysis or tenosynovectomy of achilles tendon

45.5

7.7

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.0

7.7

505

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.6

7.7

235

1659

A02BC03

ATC

lansoprazole; oral

1.7

7.5

176

1153

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.7

7.5

168

1086

R07.3

ICD-10 Finland

Other chest pain

2.4

7.4

260

R05

ICD-10 Finland

Cough

1.9

7.4

114

653

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

9.5

7.3

NB1BG

NOMESCO Finland

Shoulder and humerus MRI examination with high intensity magnet

9.5

7.3

7261X

ICD-9 Finland

Peripheral enthesopathies and allied syndromes, Rotator cuff syndrome of shoulder and allied disorders[MUU TAI TARKEMMIN MÄÄRITTELEM KIERTÄJÄKALVOSINSDR]

+∞

7.3

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

4.7

7.3

A06AC01

ATC

ispaghula (psylla seeds); oral

1.8

7.3

141

873

S19

ICPC

Skin injury other

3.4

7.2

100

NHG80

NOMESCO Finland

Fusion of first tarsometatarsal joint

3.9

7.2

205

Kela drug reimbursment

Chronic hypertension

1.7

7.2

169

1106

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

4.5

7.2

Z87.1

ICD-10 Finland

Personal history of diseases of the digestive system

1.6

7.2

268

1985

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

3.6

7.2

NF2AT

NOMESCO Finland

Injection to hip joint with ultrasound guidance

20.3

7.1

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

6.1

7.1

QCB10

NOMESCO Finland

Major dressing of wound of skin of upper limb

5.7

7.1

QDE99

NOMESCO Finland

Other excision or repair of lesion of skin of lower limb

8.9

7.1

TQW40

NOMESCO Finland

Remowal of suture of skin

2.6

7.1

203

R42

ICD-10 Finland

Dizziness and giddiness

1.9

7.0

118

692

S80.0

ICD-10 Finland

Contusion of knee

3.0

7.0

140

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

5.0

7.0

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

4.5

7.0

G47.3

ICD-10 Finland

Sleep apnoea

1.8

7.0

139

866

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.8

7.0

116

680

L88

ICPC

Rheumatoid/seropositive arthritis

3.7

6.9

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.5

6.9

210

KMAK

NOMESCO Finland

1.5

6.9

310

2391

M75.9

ICD-10 Finland

Shoulder lesion, unspecified

3.6

6.9

NGF35

NOMESCO Finland

Plastic operation of joint cartilage of knee

3.7

6.8

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.9

6.8

551

L02.4

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of limb

4.1

6.8

A02BC01

ATC

omeprazole; systemic

1.7

6.8

161

1053

M72.0

ICD-10 Finland

Palmar fascial fibromatosis [Dupuytren]

11.1

6.8

R02

ICPC

Shortness of breath/dyspnoea

2.2

6.8

321

J01MA12

ATC

levofloxacin; systemic

1.8

6.8

121

727

ZX140

NOMESCO Finland

Intra articular

16.9

6.8

A04

ICPC

Weakness/tiredness general

2.1

6.8

363

ZXD05

NOMESCO Finland

Urgent procedure

1.6

6.7

184

1254

S21

ICPC

Skin texture symptom/complaint

2.1

6.7

380

ZXD10

NOMESCO Finland

Scheduled procedure

1.6

6.7

230

1660

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

4.3

6.7

NC1AA

NOMESCO Finland

Elbow X-ray examination without contrast

4.0

6.6

Z01.2

ICD-10 Finland

Dental examination

1.6

6.6

237

1729

R4110

NOMESCO Finland

Physiotherapy

1.7

6.6

159

1047

NB2AT

NOMESCO Finland

Intra artrial injection of shoulder with ultrasound guidance

12.4

6.6

NBG00

NOMESCO Finland

Plastic operation on acromioclavicular joint

12.4

6.6

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

8.8

6.6

WX002

NOMESCO Finland

Sedation and analgesia

1.8

6.6

121

736

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.7

6.6

150

974

M54.3

ICD-10 Finland

Sciatica

3.0

6.6

120

M75.0

ICD-10 Finland

Adhesive capsulitis of shoulder

3.8

6.5

H04.10

ICD-10 Finland

Dry eye syndrome

2.4

6.5

245

M02AA10

ATC

ketoprofen; topical

1.9

6.5

518

M53.0

ICD-10 Finland

Cervicocranial syndrome

2.6

6.4

180

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

4.8

6.4

E0000UV

ATC

1.6

6.4

235

1718

M20.2

ICD-10 Finland

Hallux rigidus

3.8

6.4

Z3226

NOMESCO Finland

Physiotherapist

1.9

6.4

103

597

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

3.5

6.4

M54.2

ICD-10 Finland

Cervicalgia

2.7

6.4

164

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

2.1

6.4

349

M47.82

ICD-10 Finland

Other spondylosis, cervical region

3.6

6.4

QDE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in lower limb

4.3

6.4

K02.1

ICD-10 Finland

Caries of dentine

1.5

6.3

335

2663

AN1

Coronary angiography

2.1

6.3

353

Z01.9

ICD-10 Finland

Special examination, unspecified

2.8

6.3

141

M47.9

ICD-10 Finland

Spondylosis, unspecified

4.4

6.3

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

2.9

6.3

128

M67.0

ICD-10 Finland

Short Achilles tendon (acquired)

+∞

6.3

7290A

ICD-9 Finland

Other disorders of soft tissues, Rheumatism, unspecified and fibrositis

+∞

6.3

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.5

6.2

311

2437

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

7.1

6.2

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.6

6.2

176

1208

SPAT1254

SPAT

Administration of medicine

2.0

6.2

419

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.7

6.2

136

870

M54.6

ICD-10 Finland

Pain in thoracic spine

2.8

6.2

143

H02AB04

ATC

methylprednisolone; systemic

1.9

6.2

482

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

2.7

6.2

154

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

4.3

6.2

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

2.6

6.1

173

J01FA06

ATC

roxithromycin; oral

1.5

6.1

240

1781

S61.0

ICD-10 Finland

Open wound of finger(s) without damage to nail

2.2

6.1

301

M77.4

ICD-10 Finland

Metatarsalgia

3.4

6.1

UKC02

NOMESCO Finland

Cystoscopy

1.9

6.1

543

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.1

6.1

352

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.5

6.1

342

2746

M54

ICD-10 Finland

Dorsalgia

2.1

6.1

328

NE1AA

NOMESCO Finland

Pelvis X-ray examination

2.7

6.1

156

NK1XE

NOMESCO Finland

Other ultrasound examinnation of muscle or tendon

8.7

6.1

Z00.0

ICD-10 Finland

General medical examination

1.8

6.0

105

625

I49.5

ICD-10 Finland

Sick sinus syndrome

3.9

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_SYNOTENDINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_SYNOTENDINOTH	1.148 [0.98, 1.35]	0.091
Birth year	0.994 [0.99, 1.0]	0.143

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2095 females with M13_SYNOTENDINOTH died.

Males

Parameter	HR [95% CI]	p-value
M13_SYNOTENDINOTH	1.269 [1.11, 1.45]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 486 out of 2633 males with M13_SYNOTENDINOTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_SYNOTENDINOTH.

N-year risk	Females	Males
1	0.1%	0.256%
5	0.619%	1.539%
10	1.6%	3.883%
15	3.072%	7.347%
20	5.635%	11.901%

Relationships between endpoints

↥

Index endpoint: M13_SYNOTENDINOTH – Disorders of synovium and tendon in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_SYNOTENDINOTH
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M68\|M71[8-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M68\|M71[8-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Disorders of synovium and tendon in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints