Psoriasis (vulgaris), strict definition

PSORI_STRICT

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • L12_PSORI_VULG
7456

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • KELA reimbursements: KELA codes 319|377|134

1 out of 7 registries used, show all original rules.

1003

4. Check minimum number of events

None

1003

5. Include endpoints

None

1003

6. Filter based on genotype QC (FinnGen only)

965

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS
Control conditions
not L12_PSORI_VULG

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4808 1617 3168
Only index persons 4482 1538 2944
Unadjusted period prevalence (%)
Whole population 0.07 0.05 0.09
Only index persons 0.09 0.06 0.11
Median age at first event (years)
Whole population 51.67 54.18 50.42
Only index persons 51.17 53.78 49.80

-FinnGen-

Key figures

All Female Male
Number of individuals 965 372 593
Unadjusted period prevalence (%) 0.24 0.15 0.30
Median age at first event (years) 51.50 53.06 50.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1003
Matched controls
10029
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L40.0
ICD-10 Finland
Psoriasis vulgaris
7799.2
323.0
965
26
D07AD01
ATC
clobetasol; topical
30.0
323.0
676
647
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
+∞
323.0
667
*
E0000UV
ATC
NA
38.0
323.0
927
2437
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
121.5
323.0
811
336
D05AX52
ATC
calcipotriol, combinations; topical
394.3
323.0
843
132
D05AX03
ATC
calcitriol; topical
216.1
323.0
333
23
134
Kela drug reimbursment
General erythroderma
2507.4
323.0
331
*
D07XC01
ATC
betamethasone, combinations; topical
76.2
323.0
805
508
D05AX02
ATC
calcipotriol; topical
243.1
323.0
684
88
D05BB02
ATC
acitretin; oral
646.3
323.0
651
29
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
1380.4
323.0
411
5
L40.5
ICD-10 Finland
Arthropathic psoriasis
1611.8
323.0
394
*
E000001
ATC
NA
18.5
323.0
682
1034
D07AC01
ATC
betamethasone; topical
22.2
323.0
855
2067
377
Kela drug reimbursment
Apremilast and dimethyl fumarate (psoriasis)
+∞
252.0
231
*
L04AB04
ATC
adalimumab; parenteral
63.9
238.3
275
59
L04AC05
ATC
ustekinumab; parenteral
424.0
235.9
228
7
D07AC13
ATC
mometasone; topical
9.2
223.6
670
1793
L40
ICD-10 Finland
Psoriasis
87.7
219.3
241
36
L40.9
ICD-10 Finland
Psoriasis, unspecified
206.3
210.1
212
13
L04AC10
ATC
secukinumab; parenteral
487.1
205.2
198
5
L04AA32
ATC
apremilast; oral
+∞
202.1
187
*
E000003
ATC
NA
26.2
198.3
284
149
M07.3
ICD-10 Finland
Other psoriatic arthropathies
751.5
193.9
185
*
E000002
ATC
NA
11.8
192.8
401
535
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
34.2
190.0
251
97
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
12.1
175.5
354
433
D07AB02
ATC
hydrocortisone butyrate; topical
7.2
175.1
586
1637
L04AC16
ATC
guselkumab; systemic
+∞
170.8
159
*
L40.8
ICD-10 Finland
Other psoriasis
1822.0
160.9
152
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
88.6
159.8
176
24
TQW80
NOMESCO Finland
Local dermatologic skincare
32.6
150.0
200
76
L04AD01
ATC
ciclosporin; systemic
34.2
142.9
188
67
D07AB08
ATC
desonide; topical
9.5
142.5
327
484
S91
ICPC
Psoriasis
232.0
138.7
140
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
6.2
138.4
478
1278
L04AC13
ATC
ixekizumab; parenteral
+∞
136.7
128
*
D02AE01
ATC
carbamide; topical
11.8
129.8
257
284
6961A
ICD-9 Finland
Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]
+∞
106.2
100
*
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
102.9
97
*
D05AA
ATC
Tars
144.8
99.1
104
8
L04AB01
ATC
etanercept; parenteral
34.4
97.1
127
42
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.0
94.2
234
368
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.3
88.5
197
257
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
8.1
86.7
212
322
D02AX
ATC
Other emollients and protectives
15.8
85.6
144
105
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
82.0
588
2791
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
19.9
81.9
126
72
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
18.6
81.9
129
79
E000007
ATC
NA
9.0
77.1
173
226
E000006
ATC
NA
8.2
73.1
175
253
L40.4
ICD-10 Finland
Guttate psoriasis
738.2
71.0
69
*
A07EC01
ATC
sulfasalazine; oral, rectal
6.9
70.6
191
330
L04AC18
ATC
risankizumab; parenteral
+∞
69.6
66
*
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
703.7
67.8
66
*
299
Kela drug reimbursment
NA
+∞
66.4
63
*
L04AA01
ATC
[U] ciclosporin; systemic
19.7
62.0
95
53
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.0
61.1
162
269
D07AA02
ATC
hydrocortisone; topical
4.4
59.1
249
706
XQ848
NOMESCO Finland
Dermatological photography
14.0
55.9
98
77
D05AX05
ATC
tazarotene; topical
+∞
55.7
53
*
L04AA13
ATC
leflunomide; oral
16.2
53.6
88
59
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.8
45.3
166
401
D09AB01
ATC
zinc bandage without supplements; topical
14.6
44.0
75
55
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
31.6
40.9
54
18
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
39.9
38
*
L04AA11
ATC
[U] etanercept; parenteral
42.9
39.7
49
12
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
60.1
39.6
46
8
H02AB06
ATC
prednisolone; systemic
2.4
38.4
520
3097
M07.0
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
37.7
36
*
D05AC01
ATC
dithranol; topical
131.5
35.9
38
*
D05AX
ATC
Other antipsoriatics for topical use
+∞
34.6
33
*
L40.1
ICD-10 Finland
Generalized pustular psoriasis
+∞
34.6
33
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
34.4
480
2844
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.2
32.0
188
672
TQW99
NOMESCO Finland
Other minor procedure on skin
5.8
30.0
88
163
L26
ICD-10 Finland
Exfoliative dermatitis
85.3
29.9
33
*
L04AC
ATC
Interleukin inhibitors
+∞
27.2
26
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
27.1
134
417
J01DB01
ATC
cefalexin; oral
2.4
26.1
843
6878
L88
ICPC
Rheumatoid/seropositive arthritis
7.0
25.9
65
98
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.0
24.8
105
286
ZY010
NOMESCO Finland
Hospital outpatient
4.4
24.1
90
218
D07AC14
ATC
methylprednisolone aceponate; topical
4.6
23.2
83
192
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.5
23.1
51
63
D07BC01
ATC
betamethasone and antiseptics; topical
2.9
23.0
158
616
M07.2*L40.5
ICD-10 Finland
Psoriatic spondylitis
+∞
23.0
22
*
D07XB01
ATC
flumetasone, combinations; topical
23.6
22.7
32
14
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.1
22.2
323
1850
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.0
21.0
130
474
N05BB01
ATC
hydroxyzine; systemic
3.6
20.9
97
286
D07CC01
ATC
betamethasone and antibiotics; topical
2.6
19.9
165
716
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
19.9
238
1242
E000004
ATC
NA
7.0
19.5
48
71
J01FF01
ATC
clindamycin; systemic
2.0
19.3
305
1787
RJ421
NOMESCO Finland
NA
26.6
19.2
26
10
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
18.8
18
*
M25.5
ICD-10 Finland
Pain in joint
2.0
18.6
290
1688
R06AE07
ATC
cetirizine; oral
1.8
18.3
428
2880
ZX112
NOMESCO Finland
Subcutaneous
7.3
18.3
44
63
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
5.5
18.2
54
102
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
18.1
401
2649
A10BA02
ATC
metformin; oral
2.0
18.0
279
1616
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
11.3
17.8
33
30
RJ411
NOMESCO Finland
NA
16.0
17.6
28
18
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.7
17.2
78
226
Z3231
NOMESCO Finland
Registered nurse
2.0
17.0
280
1656
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
6.4
16.8
44
71
69600
ICD-8 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
16.7
16
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
16.6
180
891
D11AH04
ATC
alitretinoin; oral
172.7
16.5
17
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.5
16.5
43
69
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.9
16.4
102
371
NH3EA
NOMESCO Finland
Feet X-ray examination with load
7.2
16.2
39
56
E66.8
ICD-10 Finland
Other obesity
3.6
16.2
74
216
A46
ICD-10 Finland
Erysipelas
2.3
16.1
159
752
WQ031
NOMESCO Finland
NA
162.4
15.5
16
*
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
7.4
15.4
36
50
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
15.2
265
1586
A10BJ06
ATC
semaglutide; parenteral
4.4
14.8
54
129
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
14.7
99
380
T90
ICPC
Diabetes non-insulin dependent
2.0
14.7
232
1339
L04AA21
ATC
efalizumab; parenteral
+∞
14.6
14
*
WQ053
NOMESCO Finland
NA
+∞
14.6
14
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
14.5
252
1503
WQ066
NOMESCO Finland
NA
152.1
14.5
15
*
SPAT1263
SPAT
Sampling
1.7
14.4
393
2720
J01DA01
ATC
[U] cefalexin; systemic
1.7
14.3
603
4730
D07AC03
ATC
desoximetasone; topical
6.3
14.0
37
61
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.4
13.7
66
201
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.7
13.4
38
69
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
13.2
491
3682
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
13.2
246
1501
C08CA01
ATC
amlodipine; oral
1.7
12.7
303
1997
RS340
NOMESCO Finland
NA
32.5
12.6
16
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
12.6
132
641
L40.2
ICD-10 Finland
Acrodermatitis continua
131.6
12.5
13
*
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.1
12.3
155
814
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
12.3
84
326
XQ802
NOMESCO Finland
Epicutan test
3.6
12.2
55
160
M01AH05
ATC
etoricoxib; oral
1.6
11.9
580
4619
RJ420
NOMESCO Finland
NA
14.9
11.8
19
13
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
11.8
126
614
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
11.7
126
617
SPAT1262
SPAT
Handing over of treatment supplies
1.9
11.6
188
1085
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
8.2
11.6
25
31
E66.00
ICD-10 Finland
Metabolic syndrome
2.8
11.4
74
275
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
11.3
100
448
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.9
11.2
36
76
L04AB05
ATC
certolizumab pegol; parenteral
18.0
10.7
16
9
WZC30
NOMESCO Finland
Teaching
2.0
10.6
137
723
XQ800
NOMESCO Finland
Prick test
2.5
10.6
84
355
M07.1*L40.5
ICD-10 Finland
Arthritis mutilans
+∞
10.4
10
*
TNG10
NOMESCO Finland
Puncture of knee
7.8
10.4
23
30
A10BH01
ATC
sitagliptin; oral
2.3
10.2
98
456
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
10.2
128
667
L04AB06
ATC
golimumab; parenteral
8.6
10.1
21
25
J02AC01
ATC
fluconazole; systemic
1.6
9.9
314
2211
A02BC02
ATC
pantoprazole; systemic
1.5
9.9
583
4758
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
9.9
91
416
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
9.8
59
213
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
3.8
9.8
40
108
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
9.8
89
403
SPAT1301
SPAT
No procedures
1.6
9.7
269
1824
ZXC50
NOMESCO Finland
Cryotherapy
4.0
9.7
37
94
N02AX02
ATC
tramadol; systemic, rectal
1.6
9.6
380
2823
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
9.6
129
693
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.7
9.4
31
68
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
9.4
399
3010
H02AB07
ATC
prednisone; oral
2.0
9.4
130
708
L43.8
ICD-10 Finland
Other lichen planus
21.9
9.4
13
6
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
9.3
107
539
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
10.8
9.3
17
16
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
9.3
84
380
C03CA01
ATC
furosemide; systemic
1.7
9.2
194
1213
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
9.1
233
1543
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
9.1
116
610
C07AB07
ATC
bisoprolol; oral
1.5
9.1
379
2839
G47.3
ICD-10 Finland
Sleep apnoea
1.7
9.1
228
1502
D01AC02
ATC
miconazole; topical
2.3
9.0
82
372
NG1DA
NOMESCO Finland
X-ray of knees
5.8
8.9
24
42
D07XB05
ATC
dexamethasone, combinations; topical
3.7
8.9
37
102
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
12.7
8.9
15
12
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
5.7
8.8
24
43
R06AX27
ATC
desloratadine; oral
1.6
8.7
242
1638
M13.9
ICD-10 Finland
Arthritis, unspecified
2.4
8.7
72
312
160
Kela drug reimbursment
exenatide
3.9
8.7
34
89
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.4
8.7
30
70
S02CA02
ATC
flumetasone and antiinfectives; otic
2.7
8.6
56
213
J01CE08
ATC
benzathine benzylpenicillin; parenteral
8.3
8.6
18
22
XQ899
NOMESCO Finland
Other assessment of skin
16.4
8.6
13
8
M04AA01
ATC
allopurinol; systemic
2.0
8.5
110
582
D05AD01
ATC
trioxysalen; topical
90.8
8.4
9
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
8.4
427
3325
L20.0
ICD-10 Finland
Besnier prurigo
2.4
8.4
67
285
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
9.5
8.3
16
17
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
8.3
345
2570
WZA90
NOMESCO Finland
Other doctors statement
1.6
8.3
212
1403
L30.3
ICD-10 Finland
Infective dermatitis
3.2
8.2
41
131
R03AC02
ATC
salbutamol; inhalant
1.5
8.2
453
3587
291
Kela drug reimbursment
Tofacitinib
17.3
8.1
12
7
N02BE01
ATC
paracetamol; systemic, rectal
1.6
8.1
791
7063
WX110
NOMESCO Finland
Local anesthesy
1.5
8.1
649
5545
J01CE02
ATC
phenoxymethylpenicillin; oral
1.5
8.0
667
5731
S18
ICPC
Laceration/cut
1.5
8.0
364
2760
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
7.3
8.0
18
25
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
7.3
8.0
18
25
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
7.9
151
914
M01CB03
ATC
auranofin; oral
9.5
7.8
15
16
EBA00
NOMESCO Finland
Extraction of tooth
1.5
7.8
300
2192
RS221
NOMESCO Finland
NA
5.3
7.7
22
42
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.2
7.7
39
127
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
7.7
342
2580
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
7.6
243
1694
WW200
NOMESCO Finland
Immunization
3.2
7.6
38
122
S97
ICPC
Chronic ulcer skin
2.6
7.6
52
203
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
12.0
7.6
13
11
D06BB04
ATC
podophyllotoxin; topical
2.4
7.5
61
261
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
7.5
244
1710
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.4
7.5
59
251
Z3226
NOMESCO Finland
Physiotherapist
1.7
7.5
152
940
WQ054
NOMESCO Finland
NA
80.7
7.4
8
*
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
5.6
7.4
20
36
L57.0
ICD-10 Finland
Actinic keratosis
2.3
7.4
67
306
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.1
7.4
39
131
W0X00
NOMESCO Finland
Estimation of continuous need for medical therapy
+∞
7.3
7
*
L04AC12
ATC
brodalumab; systemic
+∞
7.3
7
*
R06AE09
ATC
levocetirizine; oral
1.8
7.3
131
780
L04AA29
ATC
tofacitinib; oral
15.9
7.2
11
7
SPAT1254
SPAT
Administration of medicine
1.8
7.2
118
681
D07AB01
ATC
clobetasone; topical
3.0
7.2
39
134
L04AA17
ATC
[U] adalimumab; parenteral
20.2
7.1
10
5
205
Kela drug reimbursment
Chronic hypertension
1.6
7.1
212
1454
B03BA03
ATC
hydroxocobalamin; parenteral
2.7
7.1
47
182
J01FA06
ATC
roxithromycin; oral
1.5
7.1
341
2603
4AA12
NOMESCO Finland
NA
12.1
7.1
12
10
R4180
NOMESCO Finland
Podiatric therapy
5.7
7.1
19
34
SPAT1312
SPAT
General health counselling
1.5
7.0
276
2021
L20
ICPC
Joint symptom/complaint NOS
3.1
7.0
35
114
RF410
NOMESCO Finland
NA
5.9
6.9
18
31
RF120
NOMESCO Finland
NA
5.9
6.9
18
31
J01CF05
ATC
flucloxacillin; systemic
2.7
6.9
44
165
RS121
NOMESCO Finland
NA
8.3
6.8
14
17
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
6.8
87
458
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
6.2
6.8
17
28
WQ021
NOMESCO Finland
NA
40.3
6.8
8
*
3005
Kela drug reimbursment
Tofacitinib
16.8
6.8
10
6
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.7
438
3534
A10BB12
ATC
glimepiride; oral
2.3
6.7
59
264
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.4
6.7
56
243
M54.5
ICD-10 Finland
Low back pain
1.5
6.7
283
2096
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.6
6.7
28
79
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.9
6.6
25
65
SPAT1325
SPAT
Vaccination
1.5
6.6
251
1820
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.6
296
2221
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.4
6.6
22
51
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
6.5
112
656
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.5
173
1153
SPAT1310
SPAT
Counselling related to known health issue
1.5
6.5
265
1948
RD210
NOMESCO Finland
NA
4.3
6.4
22
52
QXA70
NOMESCO Finland
Guidance related to rash and skin care
70.3
6.4
7
*
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
14.4
6.4
10
7
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.5
6.4
241
1739
J01MA02
ATC
ciprofloxacin; systemic
1.4
6.4
324
2490
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.7
6.4
41
155
WZA00
NOMESCO Finland
Short statement of of health and health related matters
2.3
6.4
59
270
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.4
78
407
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.8
6.4
38
139
R03BA05
ATC
fluticasone; inhalant
1.6
6.4
151
975
R05
ICPC
Cough
1.6
6.3
174
1167
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.6
6.3
42
164
RS211
NOMESCO Finland
NA
11.1
6.3
11
10
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.3
192
1323
L405M
ICD-10 Finland
NA
+∞
6.3
6
*
M073L
ICD-10 Finland
NA
+∞
6.3
6
*
C08CA03
ATC
isradipine; systemic
7.1
6.2
14
20
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
4.0
6.2
23
59
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.1
229
1650
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
6.1
373
2963
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
6.1
225
1616
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.3
6.1
50
219
RF420
NOMESCO Finland
NA
4.9
6.1
18
37
J01AA02
ATC
doxycycline; systemic
1.4
6.1
705
6266
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
3.6
6.0
25
71
S29
ICPC
Skin symptom/complaint other
1.7
6.0
129
808
H02AB04
ATC
methylprednisolone; systemic
1.7
6.0
123
763
S76
ICPC
Skin infection other
2.4
6.0
49
213

Mortality – FinRegistry

Association

Association between endpoint PSORI_STRICT and mortality.

Females

Parameter HR [95% CI] p-value
PSORI_STRICT 1.781 [1.33, 2.39] < 0.001
Birth year 0.994 [0.99, 1.0] 0.162

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 1071 females with PSORI_STRICT died.

Males

Parameter HR [95% CI] p-value
PSORI_STRICT 1.697 [1.39, 2.07] < 0.001
Birth year 0.99 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 2080 males with PSORI_STRICT died.

Mortality risk

Mortality risk for people of age

years, who have PSORI_STRICT.

N-year risk Females Males
1 0.142% 0.38%
5 1.044% 2.072%
10 2.618% 5.097%
15 5.037% 10.192%
20 8.678% 17.05%

Relationships between endpoints

Index endpoint: PSORI_STRICT – Psoriasis (vulgaris), strict definition

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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