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Use of galantamine

ADMED_ACHEI_GALANTAMINE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC N06DA04

1 out of 7 registries used, show all original rules.

2066

4. Check minimum number of events

Min. number of events 3
2066

5. Include endpoints

None

2066

6. Filter based on genotype QC (FinnGen only)

1983

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1983 879 1104
Unadjusted period prevalence (%) 0.46 0.35 0.55
Median age at first event (years) 79.33 78.93 79.64

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2066
Matched controls
20661
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
13.3
323.0
952
1245
P20
ICPC
Memory disturbance
7.1
323.0
1084
2771
N06DX01
ATC
memantine; oral
12.5
323.0
1088
1693
G30.1
ICD-10 Finland
Alzheimer disease with late onset
11.7
323.0
997
1529
N06DA04
ATC
galantamine; oral
+∞
323.0
2066
74
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
8.7
225.9
537
797
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
12.1
183.1
352
344
SPAT1053
SPAT
Memory test
3.9
163.4
921
3534
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
7.3
161.1
426
712
G30.8
ICD-10 Finland
Other Alzheimer disease
9.4
157.5
347
433
N05AX08
ATC
risperidone; systemic
5.2
156.5
560
1370
N06DA03
ATC
rivastigmine; oral, transdermal
5.7
130.7
419
883
P70
ICPC
Dementia
7.3
104.7
269
416
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
11.0
80.5
159
156
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.5
79.6
432
1455
N06DA02
ATC
donepezil; oral
3.5
78.2
428
1448
N05AH04
ATC
quetiapine; oral
3.4
75.3
431
1505
G30
ICD-10 Finland
Alzheimer disease
8.6
71.4
161
200
G30.0
ICD-10 Finland
Alzheimer disease with early onset
11.8
69.6
132
119
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
6.7
67.4
180
289
SPAT1216
SPAT
Assessment of functional ability
2.6
66.8
638
3066
F03
ICD-10 Finland
Unspecified dementia
3.3
58.6
338
1168
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.5
56.3
293
935
F06.7
ICD-10 Finland
Mild cognitive disorder
4.8
54.9
193
430
A28
ICPC
Limited function/disability NOS
2.3
54.0
681
3691
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
51.5
579
2955
F0019, G301
ICD-10 Finland
NA
8.1
49.9
116
151
SPAT1301
SPAT
No procedures
2.0
45.3
831
5190
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.7
44.9
350
1455
SPAT1234
SPAT
Support of social functional capacity
3.1
44.1
266
938
SPAT1254
SPAT
Administration of medicine
2.2
42.1
514
2684
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
11.7
42.1
79
70
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.3
37.7
387
1849
N06AB10
ATC
escitalopram; oral
2.5
37.5
335
1490
L28
ICPC
Limited function/disability (L)
2.0
36.1
551
3140
N06AX11
ATC
mirtazapine; oral
1.9
35.6
680
4215
N05BA04
ATC
oxazepam; oral
1.9
30.9
584
3566
N02BE01
ATC
paracetamol; systemic, rectal
1.9
30.9
1712
14720
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
6.9
29.9
76
114
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
28.3
822
5731
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
5.2
27.9
89
178
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.1
27.4
350
1826
N06AX26
ATC
vortioxetine; oral
4.2
26.2
103
256
SPAT1101
SPAT
Orthostatic test
2.5
24.4
201
849
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
24.1
480
2942
SPAT1229
SPAT
Assessment of need for aid
2.1
23.6
285
1445
SPAT1304
SPAT
Counselling and guidance related to ageing
2.1
22.6
296
1552
AA1AD
NOMESCO Finland
CT of head and brain
1.7
22.3
635
4330
R53
ICD-10 Finland
Malaise and fatigue
1.7
22.2
548
3580
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
13.4
21.5
37
28
R41.3
ICD-10 Finland
Other amnesia
3.1
21.4
123
416
SPAT1252
SPAT
Overall medication plan or its review
2.2
21.4
237
1155
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
20.9
606
4137
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
5.7
20.1
58
104
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
19.7
442
2789
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.5
19.2
153
631
A04
ICPC
Weakness/tiredness general
1.8
18.6
349
2081
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
18.5
654
4670
A29
ICPC
General symptom/complaint other
1.9
18.5
288
1609
TAB00
NOMESCO Finland
Lumbar puncture
3.8
17.4
74
199
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
17.4
655
4733
SPAT1246
SPAT
Screening of depression or other psychiatric problem
3.6
16.9
76
215
WYA20
NOMESCO Finland
Home visit
3.2
16.6
87
277
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
16.4
524
3624
130
Kela drug reimbursment
Malignant tumour
0.3
16.3
39
1197
F0009, G300
ICD-10 Finland
NA
7.7
15.4
35
46
S06.0
ICD-10 Finland
Concussion
1.9
15.3
229
1258
SPAT1263
SPAT
Sampling
1.5
15.2
808
6260
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
1.9
15.1
252
1438
SPAT1360
SPAT
Extensive global examination
2.0
15.1
199
1041
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.1
14.7
170
841
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.9
14.5
241
1373
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
14.4
693
5244
SPAT1251
SPAT
Organisation of medication
2.3
14.3
140
644
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.8
14.0
271
1620
N06AB04
ATC
citalopram; systemic
1.6
14.0
395
2635
C10AA01
ATC
simvastatin; oral
1.4
13.8
1129
9457
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
13.6
349
2269
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.8
13.3
226
1297
F00.1
ICD-10 Finland
Dementia in Alzheimer disease with late onset
11.5
13.3
24
21
N05BA06
ATC
lorazepam; systemic, sublingual
2.2
13.1
140
670
N03AG01
ATC
valproic acid; systemic, rectal
2.5
13.0
106
444
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.6
12.9
92
360
U04
ICPC
Incontinence urine
2.1
12.7
150
751
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.8
12.5
226
1319
SPAT1139
SPAT
Nutrition survey
2.5
12.0
93
379
F009, G309
ICD-10 Finland
NA
4.1
11.9
45
111
SPAT1172
SPAT
Guidance concerning hydration
2.3
11.3
103
459
SPAT1260
SPAT
Consultation of another employee
1.6
11.3
345
2337
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
7.1
11.0
26
37
H02AB02
ATC
dexamethasone; systemic
0.4
10.9
37
973
I95.1
ICD-10 Finland
Orthostatic hypotension
2.0
10.9
138
710
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
10.9
699
5519
A06AD11
ATC
lactulose; oral
1.5
10.7
468
3431
SPAT1262
SPAT
Handing over of treatment supplies
1.5
10.7
371
2589
R41.0
ICD-10 Finland
Disorientation, unspecified
2.1
10.6
116
560
F01.9
ICD-10 Finland
Vascular dementia, unspecified
2.5
10.4
78
315
Z02.7
ICD-10 Finland
Issue of medical certificate
2.0
10.4
130
664
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.9
10.4
152
826
SPAT1167
SPAT
Insertion of urinary catheter
2.1
10.2
114
559
Z75.5
ICD-10 Finland
Holiday relief care
3.0
10.0
57
193
N29
ICPC
Neurological sympt/complt other
3.3
9.8
48
149
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
9.3
760
6211
F05.1
ICD-10 Finland
Delirium superimposed on dementia
3.6
9.1
39
109
N28
ICPC
Limited function/disability (N)
3.0
8.8
48
161
SPAT1231
SPAT
Assessment of adjustments needed in living environment
2.4
8.8
76
330
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.8
8.7
154
895
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
7.7
8.6
19
25
N05AH03
ATC
olanzapine; systemic
2.4
8.6
69
290
A98
ICPC
Health maint/preventive medicine
1.4
8.5
1498
13655
SPAT1276
SPAT
Outlining of treatment with patient or their family members
2.5
8.4
64
262
A03FA01
ATC
metoclopramide; systemic, rectal
0.6
8.3
179
2675
JN4BD
NOMESCO Finland
Extensive body CT
0.5
8.1
83
1486
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
8.0
108
572
G04CA02
ATC
tamsulosin; oral
1.3
8.0
608
4888
R41
ICD-10 Finland
Other symptoms and signs involving cognitive functions and awareness
3.8
7.9
32
86
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.9
510
3990
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.9
7.8
108
578
N02AA05
ATC
oxycodone; systemic
1.4
7.7
378
2814
F0014, G301
ICD-10 Finland
NA
6.4
7.7
19
30
WX402
NOMESCO Finland
General anaesthesia
0.5
7.7
57
1122
AA1AD
SPAT
NA
10.1
7.5
14
14
C10AA05
ATC
atorvastatin; oral
1.3
7.5
787
6619
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.4
7.4
355
2630
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
0.0
7.4
*
185
XA800
NOMESCO Finland
Neuropsychological investigation
2.8
7.3
45
165
W19
ICD-10 Finland
Unspecified fall
1.6
7.3
204
1348
J01DB01
ATC
cefalexin; oral
1.3
7.3
1364
12368
N05AD01
ATC
haloperidol; systemic
2.0
7.3
88
450
A99
ICPC
Disease/condition unspecnature/site
1.7
7.2
155
957
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.7
7.2
148
901
F00.2
ICD-10 Finland
Dementia in Alzheimer disease, atypical or mixed type
15.8
7.2
11
7
K08.3
ICD-10 Finland
Retained dental root
1.8
7.2
120
684
E0000UV
ATC
NA
1.3
7.2
622
5080
Z04.3
ICD-10 Finland
Examination and observation following other accident
3.0
7.2
38
127
SPAT1014
SPAT
Treatment of eyes
2.5
7.1
53
214
E86
ICD-10 Finland
Volume depletion
2.0
7.1
80
398
N30.0
ICD-10 Finland
Acute cystitis
1.4
7.0
305
2221
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
7.0
7.0
16
23
R55
ICD-10 Finland
Syncope and collapse
1.5
6.9
278
1990
N06AB06
ATC
sertraline; oral
1.8
6.8
117
675
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
0.4
6.8
20
557
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
6.8
723
6065
SPAT1050
SPAT
Extensive neurological examination
2.3
6.7
58
257
F0029, G308
ICD-10 Finland
NA
4.7
6.7
21
45
F00.01
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly paranoidism
22.6
6.7
9
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
6.6
175
1143
F01.2
ICD-10 Finland
Subcortical vascular dementia
3.7
6.6
26
70
A04AA02
ATC
granisetron; systemic, transdermal
0.3
6.5
13
434
F00.14
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms of mixed type
6.2
6.5
16
26
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
0.4
6.5
30
695
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.4
6.4
341
2571
F01.8
ICD-10 Finland
Other vascular dementia
14.3
6.4
10
7
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
6.4
120
716
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.2
6.4
60
277
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
2.2
6.3
60
278
F00.24
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type other additional symptoms of mixed type
9.3
6.3
12
13
S01.0
ICD-10 Finland
Open wound of scalp
1.6
6.2
162
1051
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
4.3
6.2
21
49
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.3
6.2
450
3574
Z29
ICPC
Social problem NOS
2.5
6.1
44
178
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
0.7
6.1
230
3110
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
0.2
6.0
*
251
S72.0
ICD-10 Finland
Fracture of neck of femur
1.6
6.0
149
956
N27
ICPC
Fear of neurological disease other
2.7
6.0
37
138

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ADMED_ACHEI_GALANTAMINE – Use of galantamine

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).