This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Alzheimer’s disease (Early onset)
AD_EO
Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1879 |
4. Check minimum number of eventsNone |
1879 |
5. Include endpointsNone |
1879 |
6. Filter based on genotype QC (FinnGen only) |
1879 |
Control definitions (FinnGen only)
- Control exclude
- G6_ALZHEIMER
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (Early onset)
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (Early onset), excluding more controls
- Alzheimer’s disease, wide definition
- Alzheimer’s disease, wide definition, excluding more controls
- Unspecific neurodegenerative disorder
- Any dementia
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1879 | 914 | 965 |
| Unadjusted period prevalence (%) | 0.37 | 0.31 | 0.43 |
| Median age at first event (years) | 76.41 | 74.94 | 77.80 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1642
- Matched controls
- 16418
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G30.1
ICD-10 Finland
Alzheimer disease with late onset
83.1
323.0
769
172
N06DX01
ATC
memantine; oral
58.5
323.0
923
352
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
384.8
323.0
679
30
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
3821.0
323.0
551
*
N06DA02
ATC
donepezil; oral
60.6
323.0
865
296
N06DA03
ATC
rivastigmine; oral, transdermal
39.0
323.0
533
200
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
77.8
323.0
406
69
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
144.5
323.0
1003
176
G30.0
ICD-10 Finland
Alzheimer disease with early onset
6039.0
323.0
925
*
F0009, G300
ICD-10 Finland
NA
+∞
257.2
240
*
N05AX08
ATC
risperidone; systemic
10.5
239.9
520
696
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
2292.0
200.1
190
*
G30
ICD-10 Finland
Alzheimer disease
101.1
179.8
196
22
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.8
176.2
456
773
F0019, G301
ICD-10 Finland
NA
+∞
167.6
158
*
N06DA04
ATC
galantamine; oral
27.5
165.6
231
97
F03
ICD-10 Finland
Unspecified dementia
7.3
147.0
391
672
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
36.7
146.1
189
58
G30.8
ICD-10 Finland
Other Alzheimer disease
36.8
133.2
172
52
P20
ICPC
Memory disturbance
4.9
131.4
512
1388
F009, G309
ICD-10 Finland
NA
+∞
128.9
122
*
N05AH04
ATC
quetiapine; oral
5.4
126.8
440
1044
P70
ICPC
Dementia
17.4
120.4
195
126
TAB00
NOMESCO Finland
Lumbar puncture
13.7
108.4
194
159
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
21.1
72.8
109
55
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
38.0
70.6
90
25
XA800
NOMESCO Finland
Neuropsychological investigation
9.6
64.8
137
154
SPAT1053
SPAT
Memory test
2.8
54.9
426
1820
F06.7
ICD-10 Finland
Mild cognitive disorder
6.8
53.9
142
225
N03AG01
ATC
valproic acid; systemic, rectal
5.3
47.2
153
314
N05BA04
ATC
oxazepam; oral
2.4
45.0
498
2548
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.9
41.5
185
520
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.1
40.2
166
435
N06AB10
ATC
escitalopram; oral
2.8
40.1
296
1201
R41.3
ICD-10 Finland
Other amnesia
5.6
37.7
114
215
F00.09
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset information on additional symptoms is lacking
+∞
37.6
36
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.5
35.6
176
538
Z75.5
ICD-10 Finland
Holiday relief care
7.4
35.2
86
122
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
34.3
627
3897
R53
ICD-10 Finland
Malaise and fatigue
2.1
32.3
441
2425
N05AD01
ATC
haloperidol; systemic
4.2
31.9
126
316
N06AB04
ATC
citalopram; systemic
2.2
31.7
404
2150
F05.1
ICD-10 Finland
Delirium superimposed on dementia
16.6
31.2
50
31
F00.01
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly paranoidism
318.6
30.9
31
*
N05BA06
ATC
lorazepam; systemic, sublingual
3.5
30.6
154
476
N06AX11
ATC
mirtazapine; oral
2.0
30.6
511
3037
N05AH03
ATC
olanzapine; systemic
4.9
30.3
103
222
N07AA05
ATC
NA
296.9
28.9
29
*
A28
ICPC
Limited function/disability NOS
2.1
28.6
401
2210
F0029, G308
ICD-10 Finland
NA
+∞
28.2
27
*
F0014, G301
ICD-10 Finland
NA
+∞
27.2
26
*
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.6
25.4
208
883
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
25.3
606
4030
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
24.5
89
2236
SPAT1234
SPAT
Support of social functional capacity
2.9
24.0
156
575
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
11.3
22.4
42
38
F00
ICD-10 Finland
Dementia in Alzheimer disease
24.3
22.2
31
13
F0004, G300
ICD-10 Finland
NA
+∞
21.9
21
*
Z2445
NOMESCO Finland
Psychologist
5.7
21.7
63
114
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
21.7
117
381
N05AD03
ATC
melperone; systemic
4.8
21.6
73
157
SPAT1216
SPAT
Assessment of functional ability
2.0
21.3
334
1899
A06AD11
ATC
lactulose; oral
1.8
21.2
410
2507
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
21.2
309
1706
F00.1
ICD-10 Finland
Dementia in Alzheimer disease with late onset
60.8
20.9
24
*
WYA20
NOMESCO Finland
Home visit
4.8
20.8
70
150
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
19.8
215
1047
F00.0
ICD-10 Finland
Dementia in Alzheimer disease with early onset
106.3
19.6
21
*
S18
ICPC
Laceration/cut
0.5
18.9
253
4109
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
70.7
18.7
21
*
F001, G301
ICD-10 Finland
NA
44.5
18.3
22
5
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
18.1
98
321
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
3.0
17.8
107
375
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
5.3
17.8
54
104
F00.14
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms of mixed type
67.3
17.7
20
*
F000, G300
ICD-10 Finland
NA
+∞
17.7
17
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
17.7
374
2336
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
4.8
17.2
57
121
N02AJ06
ATC
codeine and paracetamol; systemic
0.5
17.0
156
2836
R41.0
ICD-10 Finland
Disorientation, unspecified
2.9
16.6
101
357
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
16.0
310
1875
F00.04
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms of mixed type
+∞
15.6
15
*
SPAT1153
SPAT
Removal of sutures
0.5
15.5
175
3003
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
15.4
138
611
SPAT1254
SPAT
Administration of medicine
1.8
15.2
287
1723
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
14.7
304
1875
F0001, G300
ICD-10 Finland
NA
+∞
14.6
14
*
F0009, G309
ICD-10 Finland
NA
+∞
14.6
14
*
G31.0
ICD-10 Finland
Circumscribed brain atrophy
10.1
14.5
28
28
SPAT1251
SPAT
Organisation of medication
2.7
14.4
100
385
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.5
14.2
112
2147
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
42.9
14.1
17
*
Z13.3
ICD-10 Finland
Special screening examination for mental and behavioural disorders
42.9
14.1
17
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.2
14.1
74
238
130
Kela drug reimbursment
Malignant tumour
0.3
13.8
24
855
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.6
13.7
103
414
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.5
13.4
106
440
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
13.3
131
607
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
12.9
289
1818
S72.0
ICD-10 Finland
Fracture of neck of femur
2.2
12.2
133
645
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.5
12.0
97
1852
L28
ICPC
Limited function/disability (L)
1.6
11.5
308
2036
3310A
ICD-9 Finland
Other cerebral degenerations, Alzheimer's disease
+∞
11.5
11
*
R55
ICD-10 Finland
Syncope and collapse
1.8
11.1
217
1307
LAITO
NOMESCO Finland
NA
21.6
10.7
15
7
F00.02
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly illusions
+∞
10.4
10
*
N07AA06
ATC
NA
+∞
10.4
10
*
L82
ICD-10 Finland
Seborrhoeic keratosis
0.5
10.4
66
1365
N02AA05
ATC
oxycodone; systemic
1.6
10.3
280
1855
F00.11
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms, mainly paranoidism
40.3
10.0
12
*
AA1AD
NOMESCO Finland
CT of head and brain
1.5
9.6
387
2806
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
9.6
205
1268
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.5
9.6
62
1275
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.8
9.6
60
219
207
Kela drug reimbursment
Chronic arrhythmias
0.6
9.5
132
2171
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.5
9.5
87
1600
-
ICD-10 Finland
NA
3.0
9.4
52
176
L17
ICPC
Foot/toe symptom/complaint
0.6
9.2
134
2177
J01CA08
ATC
pivmecillinam; oral
1.4
9.1
580
4594
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.0
9.0
119
627
L57.0
ICD-10 Finland
Actinic keratosis
0.5
9.0
66
1300
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.3
8.9
84
383
N02BE01
ATC
paracetamol; systemic, rectal
1.4
8.9
1206
10861
H02AB02
ATC
dexamethasone; systemic
0.4
8.8
29
767
E86
ICD-10 Finland
Volume depletion
2.5
8.8
67
276
H04AA01
ATC
glucagon; nasal, parenteral
4.8
8.6
27
57
F0011, G301
ICD-10 Finland
NA
90.5
8.4
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
0.7
8.3
388
4995
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.6
8.2
209
1354
S06.0
ICD-10 Finland
Concussion
1.8
8.2
147
862
K86
ICPC
Hypertension uncomplicated
0.5
8.1
53
1087
L08
ICPC
Shoulder symptom/complaint
0.5
8.1
85
1508
N06AB06
ATC
sertraline; oral
1.9
8.1
112
601
R1250
NOMESCO Finland
Evaluation of functional capability
3.5
8.1
36
105
H81
ICPC
Excessive ear wax
0.6
8.1
108
1792
N05CD07
ATC
temazepam; oral
1.5
8.1
287
2021
WX402
NOMESCO Finland
General anaesthesia
0.4
7.9
40
897
H02AB06
ATC
prednisolone; systemic
0.7
7.9
444
5563
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.5
7.9
35
102
A03FA01
ATC
metoclopramide; systemic, rectal
0.6
7.9
133
2088
DFF00
NOMESCO Finland
Pure tone audiometry
0.4
7.8
30
746
B03BA03
ATC
hydroxocobalamin; parenteral
1.8
7.7
133
769
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
0.6
7.7
139
2151
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
3.7
7.7
31
84
R05
ICPC
Cough
0.6
7.6
100
1674
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.8
7.6
46
167
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
0.6
7.5
126
1982
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
0.4
7.4
33
772
JN4AD
NOMESCO Finland
Body CT examination
0.3
7.4
20
575
F0002, G300
ICD-10 Finland
NA
+∞
7.3
7
*
F0001, G301
ICD-10 Finland
NA
+∞
7.3
7
*
B01AF02
ATC
apixaban; oral
0.5
7.3
63
1180
C04AE01
ATC
ergoloid mesylates; systemic
3.3
7.3
34
104
WX100
NOMESCO Finland
Conjunctival surface anesthesia
0.5
7.1
72
1288
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
5.3
7.1
20
38
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
10.1
7.0
13
13
A98
ICPC
Health maint/preventive medicine
0.8
7.0
915
10252
SPAT1229
SPAT
Assessment of need for aid
1.7
6.9
146
899
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
5.5
6.9
19
35
N06AX26
ATC
vortioxetine; oral
2.5
6.9
50
203
M01AH05
ATC
etoricoxib; oral
0.7
6.9
401
5023
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
6.8
226
1564
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.1
6.8
73
357
A69
ICPC
General and Unspecified, Other reason for encounter NEC
2.4
6.8
52
217
H84
ICPC
Presbyacusis
0.3
6.8
11
406
K85
ICPC
Elevated blood pressure
0.6
6.7
87
1456
F009, F03
ICD-10 Finland
NA
22.6
6.7
9
*
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.9
6.7
20
41
M79.6
ICD-10 Finland
Pain in limb
0.7
6.6
244
3286
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
12.3
6.6
11
9
F05.9
ICD-10 Finland
Delirium, unspecified
2.4
6.4
50
211
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
14.4
6.4
10
7
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
0.3
6.4
16
475
L03
ICPC
Low back symptom/complaint
0.6
6.4
122
1864
R41
ICD-10 Finland
Other symptoms and signs involving cognitive functions and awareness
4.9
6.4
19
39
F0009, G301
ICD-10 Finland
NA
+∞
6.3
6
*
F0003, G300
ICD-10 Finland
NA
+∞
6.3
6
*
F00.03
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenil onset other additional symptoms, mainly depression
+∞
6.3
6
*
F0023, G308
ICD-10 Finland
NA
+∞
6.3
6
*
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.8
6.2
108
630
R06.0
ICD-10 Finland
Dyspnoea
0.7
6.2
224
3036
E000001
ATC
NA
1.4
6.2
263
1911
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
6.3
6.2
15
24
K80
ICPC
Cardiac arrhythmia NOS
0.4
6.1
23
576
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
0.6
6.1
87
1422
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
6.0
178
1198
W19
ICD-10 Finland
Unspecified fall
1.6
6.0
148
951
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: AD_EO – Alzheimer’s disease (Early onset)
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).