thyroid carcinoma: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1213 |
4. Check minimum number of eventsNone |
1213 |
5. Include endpointsNone |
1213 |
6. Filter based on genotype QC (FinnGen only) |
1213 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D10-D36
- Name in latin
- Neoplasma benignum glandulae thyreoideae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of thyroid gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of thyroid gland
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7907 | 6229 | 1639 |
| Only index persons | 7326 | 5875 | 1451 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.18 | 0.05 |
| Only index persons | 0.18 | 0.22 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 51.68 | 50.47 | 56.14 |
| Only index persons | 50.64 | 49.65 | 54.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1213 | 936 | 277 |
| Unadjusted period prevalence (%) | 0.27 | 0.32 | 0.12 |
| Median age at first event (years) | 51.45 | 49.43 | 58.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1088
- Matched controls
- 10879
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
79.2
323.0
477
106
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
11426.5
323.0
883
*
2260A
ICD-9 Finland
Benign neoplasm of thyroid gland[NEOPLASMA BENIGNUM GLANDULAE THYREOIDEAE]
+∞
214.9
199
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
52.7
189.8
227
54
H03AA01
ATC
levothyroxine sodium; systemic
4.6
115.3
554
1984
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
18.5
89.2
141
87
2504
FHL
Unilateral resection or enucleation
36.6
86.9
112
34
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
22.8
79.9
117
57
104
Kela drug reimbursment
Thyroid insufficiency
5.8
77.6
247
527
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
8.5
75.6
176
242
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
16.2
74.2
123
85
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.5
64.8
181
322
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
20.1
63.1
96
52
BAA60
NOMESCO Finland
Total thyroidectomy
10.8
57.7
115
118
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.7
54.3
114
129
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
12.3
47.7
88
77
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
13.1
34.9
62
50
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
10.7
34.3
67
66
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
70.0
30.0
34
5
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
48.5
27.6
33
7
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.3
25.7
54
61
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
21.3
190
858
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
26.1
20.5
28
11
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
11.2
20.3
38
35
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
10.6
20.2
39
38
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
26.6
19.2
26
10
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
14.0
17.8
30
22
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.0
17.1
70
185
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
64.4
16.8
19
*
BAA30
NOMESCO Finland
Excision of thyroid isthmus
45.7
15.1
18
*
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
13.4
12.5
21
16
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.8
10.9
30
53
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
18.0
10.7
16
9
E03
ICD-10 Finland
Other hypothyroidism
2.5
10.6
86
365
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
10.3
386
2824
E83.51
ICD-10 Finland
Hypocalcemia
11.5
9.6
17
15
2506
FHL
Thyroidectomy
11.5
9.6
17
15
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
30.3
9.4
12
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.5
9.3
73
307
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
9.3
234
1538
T86
ICPC
Hypothyroidism/myxoedema
2.7
9.0
61
236
106
Kela drug reimbursment
Hypoparathyroidism
12.7
8.9
15
12
R13
ICD-10 Finland
Dysphagia
2.3
8.6
75
334
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.4
288
2044
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
12.9
8.4
14
11
A02BC05
ATC
esomeprazole; systemic
1.5
8.3
427
3312
A11CC03
ATC
alfacalcidol; systemic
4.1
8.1
30
75
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
22.2
8.0
11
5
WZC30
NOMESCO Finland
Teaching
1.8
7.6
139
829
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.3
234
1625
T72
ICPC
Benign neoplasm thyroid
10.9
7.3
13
12
Z00.0
ICD-10 Finland
General medical examination
1.6
7.2
185
1219
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
8.8
7.1
14
16
ZX114
NOMESCO Finland
Intramuscular
3.9
7.0
27
71
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
5.9
6.6
17
29
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.6
6.6
21
46
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
12.3
6.6
11
9
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.4
103
587
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
70.2
6.4
7
*
R01AD09
ATC
mometasone; nasal
1.4
6.4
458
3733
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.3
289
2167
T71
ICPC
Malignant neoplasm thyroid
18.1
6.3
9
5
D44
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of endocrine glands
+∞
6.3
6
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.1
351
2743
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
131
94
15.50
145.35
6.2
4.4
32.9
52.9
u/ml
0.63
44
29
180
296
6.97
107.67
1.4
1.2
—
—
—
0
0
202
658
3.48
50.94
4.6
3.2
4.4
4.5
pmol/l
0.21
184
576
1054
8284
3.08
40.47
7.4
4.2
15.5
14.8
pmol/l
16.12
986
7511
721
5211
1.95
27.33
7.8
6.1
1.2
1.2
mmol/l
1.04
606
4394
1113
9663
2.84
23.48
8.5
5.1
1.8
2.0
mu/l
1.23
1041
8824
639
4732
1.74
19.55
6.1
5.4
1.2
1.2
mmol/l
1.75
588
4280
158
855
1.97
12.99
4.3
3.4
1.2
1.2
mmol/l
1.09
143
736
147
841
1.85
10.15
2.9
3.4
67.2
80.9
ng/l
1.81
127
735
888
7739
1.55
10.10
4.6
4.2
12.4
12.5
mm/h
0.07
829
7149
474
3676
1.48
9.41
2.8
3.4
2.3
2.4
mmol/l
4.10
409
3204
599
4892
1.44
8.91
4.3
3.9
—
—
—
0
0
557
4501
1.44
8.71
2.5
2.3
79.6
78.4
nmol/l
0.46
507
4020
125
753
1.74
7.24
1.2
1.2
105.1
144.0
iu/ml
0.55
53
298
1113
10573
1.64
5.33
17.1
15.6
139.8
139.7
mmol/l
1.61
1099
10296
883
8052
1.36
5.16
8.5
7.3
77.3
77.7
u/l
0.11
836
7554
1114
10598
1.63
5.13
17.3
15.7
3.9
4.0
mmol/l
2.31
1099
10305
673
5908
1.31
5.11
4.5
4.3
6.6
6.7
mmol/l
0.58
645
5498
525
4508
1.29
4.50
2.7
2.7
114.8
109.4
ug/l
0.24
476
4151
215
1631
1.39
4.33
2.8
2.9
0.8
0.8
mmol/l
0.44
197
1520
312
2517
1.32
4.20
2.4
2.2
—
—
—
0
0
1075
10236
1.44
3.97
15.4
13.7
21.1
22.3
mg/l
0.58
867
8064
333
2751
1.29
3.71
4.9
4.2
0.0
0.0
estimate
1.08
142
946
10
25
4.02
3.70
2.2
2.0
—
—
—
0
0
668
6018
1.24
3.49
9.5
9.0
4.0
4.0
e9/l
0.02
598
5270
24
106
2.29
3.47
1.1
1.1
—
—
—
0
0
1164
11320
1.70
3.35
23.4
20.6
253.7
255.6
e9/l
0.48
1134
11040
1164
11327
1.68
3.24
23.3
20.6
4.5
4.4
e12/l
1.42
1130
11014
1164
11329
1.68
3.21
23.3
20.6
6.5
6.7
e9/l
1.31
1131
11012
1164
11330
1.68
3.20
23.4
20.7
134.1
133.4
g/l
0.94
1153
11168
1127
10893
1.49
3.18
11.8
10.4
24.2
24.7
u/l
0.65
1085
10516
36
194
1.88
3.13
3.4
3.3
4.0
4.2
e9/l
0.27
36
194
446
3878
1.24
3.13
3.8
3.5
29.6
43.3
ng/l
0.47
298
2634
30
154
1.97
3.01
2.0
3.3
1.8
1.3
%
0.17
17
126
17
70
2.45
2.88
1.4
1.2
—
—
—
0
0
141
1068
1.36
2.88
4.6
4.1
227.1
252.9
u/l
1.60
132
1006
378
3255
1.23
2.85
2.6
2.4
61.3
56.7
u/l
0.29
342
2999
272
2261
1.26
2.81
1.8
1.7
37387829.8
27341661.0
pmol/l
0.10
222
1858
505
4485
1.22
2.81
4.2
4.4
35.7
35.6
g/l
0.14
459
4164
140
1064
1.36
2.80
3.4
3.2
—
—
—
0
0
36
202
1.81
2.79
3.7
3.6
57.2
58.5
%
0.27
36
202
679
6214
1.21
2.75
3.0
3.0
—
—
—
0
0
234
1916
1.27
2.74
1.3
1.3
30.1
32.5
iu/ml
0.11
84
627
51
319
1.63
2.70
1.6
1.6
0.2
0.1
iu/ml
0.40
14
58
60
394
1.55
2.61
2.1
2.0
1.0
2.1
ug/l
0.71
52
348
55
355
1.58
2.58
2.1
1.7
—
—
—
0
0
34
196
1.76
2.45
4.1
3.5
156.0
1822.5
u/ml
0.71
27
186
328
2825
1.22
2.42
1.6
1.6
1.3
1.4
mmol/l
1.80
268
2372
443
3929
1.20
2.41
4.7
4.0
—
—
—
0
0
5
8
6.27
2.37
1.0
1.1
—
—
—
0
0
357
3109
1.21
2.35
3.2
3.1
7.0
7.0
mmol/l
0.05
291
2603
81
581
1.42
2.32
2.4
3.4
5.2
5.2
kpa
0.09
72
545
1043
10039
1.28
2.31
4.8
4.6
5.9
5.9
mmol/l
0.41
942
9123
211
1742
1.26
2.30
1.6
1.5
—
—
—
0
0
273
2321
1.23
2.28
1.2
1.3
0.9
1.5
u/ml
1.00
79
611
356
3110
1.20
2.26
4.1
3.9
9.1
7.7
mg/mmol
0.20
192
1840
29
165
1.78
2.20
1.1
1.2
—
—
—
0
0
57
391
1.48
2.08
2.3
1.9
—
—
—
0
0
591
5426
1.17
2.07
6.9
5.9
11.2
10.8
umol/l
0.21
561
5144
24
133
1.82
2.00
1.3
1.3
—
—
—
0
0
24
133
1.82
2.00
1.3
1.3
—
—
—
0
0
24
133
1.82
2.00
1.3
1.3
—
—
—
0
0
43
280
1.56
2.00
1.8
1.9
2.2
5.0
iu/l
3.65
12
106
24
134
1.81
1.96
1.3
1.3
—
—
—
0
0
156
1269
1.26
1.94
27.5
23.8
1.3
1.3
inr
0.08
33
160
24
135
1.79
1.92
1.3
1.3
—
—
—
0
0
24
135
1.79
1.92
1.3
1.3
—
—
—
0
0
160
1310
1.26
1.89
4.7
4.5
33.1
32.7
%
0.15
107
871
75
553
1.38
1.88
2.2
3.4
2.3
1.9
mmol/l
0.49
62
420
738
6929
1.17
1.87
5.2
4.7
68.6
1998.2
e6/l
—
5
99
1050
10166
1.24
1.85
4.5
4.4
4.7
4.7
mmol/l
0.22
953
9381
26
153
1.71
1.80
1.6
1.3
0.6
0.6
nmol/l
0.08
26
145
42
280
1.52
1.78
1.8
2.0
4382.6
3794.7
u/l
0.05
15
107
297
2604
1.19
1.78
2.5
2.5
322.0
5559.1
umol/l
8.36
250
2250
348
3093
1.18
1.77
2.0
2.1
147.3
219.7
u/l
1.26
323
2905
35
225
1.57
1.75
1.3
1.3
—
—
—
0
0
86
658
1.33
1.72
1.2
1.2
172.1
163.3
u/ml
0.05
79
600
35
226
1.56
1.72
2.4
2.7
26.1
25.2
mmol/l
0.68
29
199
1068
10376
1.25
1.71
5.1
4.9
2.8
2.8
mmol/l
0.27
963
9520
155
1280
1.24
1.71
4.5
4.6
1.0
1.0
mmol/l
0.12
146
1174
1042
10099
1.23
1.70
4.5
4.4
1.5
1.5
mmol/l
0.30
944
9256
0
48
0.00
1.70
0.0
2.1
—
47.1
—
0
34
66
487
1.38
1.67
3.0
2.8
0.2
0.2
e6/l
0.10
66
470
30
189
1.60
1.64
2.1
2.2
16.7
16.0
%
0.36
14
92
73
957
0.75
1.64
2.1
2.2
59.4
35.4
u/l
0.54
63
807
118
952
1.27
1.60
2.2
2.1
0.2
0.2
g/l
0.74
106
901
548
5074
1.15
1.58
4.5
3.8
0.0
0.0
estimate
0.00
150
960
39
265
1.49
1.55
1.3
1.3
—
—
—
0
0
10
44
2.28
1.53
1.3
1.2
—
—
—
0
0
10
44
2.28
1.53
1.3
1.2
—
—
—
0
0
119
969
1.25
1.51
2.8
2.0
353.2
375.2
nmol/l
0.58
103
886
41
284
1.46
1.49
1.6
1.6
—
—
—
0
0
230
2004
1.18
1.48
2.5
2.9
2.4
2.5
mmol/l
1.70
203
1766
57
422
1.37
1.44
1.3
1.3
0.3
1.0
u/ml
—
9
33
276
2446
1.17
1.44
1.5
1.5
21.5
21.3
nmol/l
0.10
237
2057
213
1850
1.18
1.42
1.3
1.3
6.2
14.4
u/ml
1.84
93
704
1003
9728
1.18
1.39
14.9
12.7
79.6
80.2
ml/min/173m2
0.36
850
7989
287
2564
1.16
1.35
2.3
2.1
2.9
3.0
mg/l
0.38
239
2170
21
128
1.65
1.33
1.9
1.6
—
—
—
0
0
549
5125
1.13
1.33
5.7
5.2
0.0
0.0
estimate
0.50
147
961
554
5177
1.13
1.32
4.4
3.8
0.0
0.0
estimate
0.80
149
935
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
148
1256
1.20
1.29
2.4
2.2
105.3
123.4
ug/g
0.51
112
987
8
34
2.36
1.29
3.4
4.7
—
—
—
0
0
5
18
2.78
1.28
1.4
2.9
—
—
—
0
0
18
107
1.69
1.26
1.2
1.4
—
—
—
0
0
38
270
1.42
1.25
1.2
1.1
—
—
—
0
0
27
397
0.67
1.24
1.4
1.5
—
—
—
0
0
164
1412
1.19
1.23
2.3
2.2
2.4
2.4
g/l
0.41
150
1301
5
19
2.64
1.21
1.2
1.1
—
—
—
0
0
185
1618
1.17
1.16
1.8
1.8
—
—
—
0
0
18
110
1.65
1.15
5.3
2.1
31.9
32.2
pg
0.12
18
110
1002
9754
1.16
1.15
4.0
3.9
1.3
1.3
mmol/l
0.28
898
8881
978
9506
1.15
1.14
5.8
5.7
39.8
39.7
mmol/mol
0.21
889
8781
52
399
1.32
1.10
2.2
2.1
12.5
12.2
nmol/l
0.09
44
352
322
2940
1.13
1.09
2.8
2.9
947.4
1148.5
ng/l
0.52
273
2481
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
98
815
1.22
1.08
1.7
1.8
—
—
—
0
0
11
59
1.87
1.07
2.1
2.1
—
—
—
0
0
12
203
0.59
1.04
1.2
1.4
—
—
—
0
0
12
203
0.59
1.04
1.2
1.4
—
—
—
0
0
107
903
1.20
1.02
1.7
2.0
—
—
—
0
0
126
1081
1.18
1.01
4.4
3.9
14.0
19.4
ug/l
0.24
98
878
12
68
1.77
1.00
1.5
1.6
13.2
19.0
nmol/l
2.07
12
62
5
23
2.18
0.98
1.2
1.1
—
—
—
0
0
60
479
1.27
0.97
1.4
1.3
30.6
32.3
iu/l
0.16
55
412
10
54
1.86
0.96
1.3
1.2
—
—
—
0
0
10
54
1.86
0.96
1.1
1.5
—
—
—
0
0
10
54
1.86
0.96
1.3
1.2
—
—
—
0
0
16
101
1.59
0.93
1.8
2.2
16.2
5.1
umol/l
—
9
67
9
52
1.74
0.92
1.3
1.1
208.3
470.3
u/l
—
9
47
48
608
0.78
0.92
13.0
7.9
0.8
0.7
%
0.78
48
603
54
430
1.27
0.90
1.2
1.4
—
—
—
0
0
19
127
1.50
0.89
1.5
1.6
46.8
61.2
%
0.65
12
81
8
43
1.87
0.87
1.3
1.6
—
68.2
%
—
0
6
6
30
2.00
0.87
1.3
1.3
—
—
—
0
0
172
1537
1.14
0.84
2.3
2.2
13.8
13.0
umol/l
0.74
161
1407
234
2132
1.12
0.83
2.5
2.5
5.1
7.0
e6/l
1.07
201
1887
118
1029
1.16
0.81
3.7
3.1
0.8
0.8
ug/l
0.02
80
679
56
457
1.24
0.78
2.2
2.2
35.8
39.3
u/l
0.76
51
405
0
26
0.00
0.78
0.0
1.0
—
35.4
—
0
26
99
854
1.17
0.78
3.4
3.1
2.6
1.9
mmol/l
1.19
79
683
23
315
0.72
0.78
6.5
3.8
4.0
3.9
mmol/l
0.44
23
292
5
98
0.51
0.78
1.4
1.2
—
—
—
0
0
70
586
1.21
0.77
1.7
1.5
—
—
—
0
0
15
99
1.52
0.75
1.1
1.1
56.1
55.3
u/l
—
7
70
209
1908
1.12
0.73
3.7
3.7
199.8
323.7
ng/l
0.55
143
1454
194
1765
1.12
0.72
5.7
5.1
2.2
2.6
ug/l
0.70
168
1566
73
620
1.19
0.70
7.2
6.9
25.0
24.7
mmol/l
0.29
66
585
15
217
0.69
0.70
3.2
3.9
27.1
24.7
mg/l
—
6
133
17
118
1.45
0.69
1.4
1.8
90.7
89.7
%
0.24
17
118
51
615
0.82
0.68
12.5
7.7
1.4
1.4
%
0.02
51
609
24
317
0.75
0.67
1.1
2.1
40.9
38.0
g/l
1.34
16
280
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
62
1.62
0.65
1.1
1.2
—
—
—
0
0
14
201
0.69
0.64
2.6
2.8
32.7
35.6
umol/l
0.28
14
171
219
2021
1.10
0.64
1.4
1.4
—
—
—
0
0
101
1142
0.87
0.63
2.0
2.5
9.3
7.5
umol/l
0.25
86
984
13
88
1.48
0.60
1.1
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
18
243
0.74
0.59
1.5
1.4
—
—
—
0
0
8
53
1.51
0.58
1.1
1.5
—
—
—
0
0
35
430
0.81
0.57
3.8
2.9
24.7
24.1
mmol/l
0.56
30
383
144
1308
1.11
0.57
2.3
2.3
24.4
22.4
%
0.80
115
1113
34
416
0.81
0.55
2.2
1.8
1.5
1.5
g/l
0.02
29
361
42
349
1.21
0.54
2.2
1.8
—
—
—
0
0
683
6632
1.07
0.54
3.2
3.0
47.1
46.1
u/l
0.10
638
6169
11
74
1.49
0.53
1.7
1.3
1.0
1.0
g/l
0.26
11
74
36
295
1.23
0.53
1.2
1.3
182.7
230.1
miu/ml
0.44
20
136
6
39
1.54
0.53
1.0
1.1
2077.8
1876.1
miu/ml
—
6
39
6
39
1.54
0.53
1.0
1.2
—
—
—
0
0
17
126
1.35
0.51
2.9
2.1
23.2
35.7
u/ml
0.15
17
121
11
75
1.47
0.50
1.1
1.6
—
—
—
0
0
36
297
1.22
0.50
2.1
1.5
322.6
313.6
mu/l
0.08
36
271
9
65
1.39
0.50
1.1
1.5
—
—
—
0
0
16
213
0.75
0.50
1.5
1.4
—
—
—
0
0
16
213
0.75
0.50
1.5
1.4
—
—
—
0
0
16
212
0.75
0.49
1.5
1.4
—
—
—
0
0
16
212
0.75
0.49
1.5
1.4
—
—
—
0
0
7
47
1.49
0.47
1.0
1.1
—
—
—
0
0
155
1432
1.09
0.47
5.1
4.4
22.6
21.0
%
0.66
85
684
868
8516
1.07
0.47
17.2
16.9
13.6
13.7
%
1.27
855
8331
79
703
1.13
0.47
1.7
1.6
—
—
—
0
0
21
164
1.29
0.46
1.1
1.1
—
12.5
—
0
11
28
342
0.81
0.46
1.4
2.4
0.3
1.1
g/l
1.67
18
304
7
50
1.40
0.45
1.4
2.1
—
—
—
0
0
20
157
1.28
0.43
1.1
1.1
—
—
—
0
0
6
91
0.66
0.42
2.5
2.3
—
—
—
0
0
46
530
0.86
0.41
1.3
1.4
—
—
—
0
0
8
58
1.38
0.41
1.1
1.1
—
—
—
0
0
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.3
—
1.8
—
0
11
94
1030
0.91
0.39
1.5
1.7
1.4
1.4
%
0.01
81
903
5
35
1.43
0.39
1.6
1.4
7.8
9.0
ug/l
—
5
35
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
17
133
1.28
0.38
1.1
1.3
6.6
7.4
mmol/l
—
10
90
9
67
1.35
0.38
1.3
1.2
—
—
—
0
0
9
67
1.35
0.38
1.3
1.2
—
—
—
0
0
35
299
1.18
0.37
2.9
2.8
—
—
—
0
0
16
202
0.79
0.37
1.7
1.6
—
—
—
0
0
159
1694
0.93
0.36
2.7
2.6
0.9
1.2
e6/l
0.94
94
934
12
90
1.34
0.36
1.2
1.4
1.4
1.3
nmol/l
0.08
12
78
19
153
1.25
0.35
1.6
1.6
41.6
43.8
nmol/l
0.16
19
146
6
44
1.37
0.34
2.2
2.3
—
—
—
0
0
58
520
1.12
0.33
1.0
1.0
—
—
—
0
0
138
1293
1.08
0.33
6.9
7.1
—
—
—
0
0
12
154
0.78
0.32
1.8
1.7
—
—
—
0
0
245
2343
1.06
0.32
2.0
1.7
0.9
1.1
mg/l
0.71
189
1800
148
1568
0.94
0.30
2.8
2.7
2.3
3.2
e6/l
0.67
83
813
7
54
1.30
0.30
3.9
3.8
—
—
—
0
0
34
297
1.15
0.29
4.7
3.9
1.3
1.8
ratio
—
7
28
18
148
1.22
0.29
1.2
1.3
106.1
113.8
u/ml
—
7
35
8
106
0.75
0.29
1.0
1.1
—
—
—
0
0
43
383
1.13
0.29
1.3
1.7
—
—
—
0
0
16
131
1.22
0.27
1.1
1.5
—
—
—
0
0
16
131
1.22
0.27
1.1
1.5
—
—
—
0
0
8
65
1.23
0.27
1.3
1.4
—
—
—
0
0
11
139
0.79
0.27
1.0
1.1
—
—
—
0
0
204
1953
1.05
0.26
1.8
1.7
1115.3
1206.0
nmol/l
0.76
154
1449
55
602
0.91
0.25
11.7
8.0
93.1
93.9
%
0.31
55
595
90
840
1.08
0.25
2.5
2.8
68.5
66.9
g/l
1.40
81
762
18
151
1.19
0.25
1.0
1.0
1.5
2.2
u/ml
—
8
61
9
75
1.20
0.25
1.1
1.1
—
—
—
0
0
85
793
1.08
0.24
3.8
3.0
115.3
197.8
ng/l
3.99
78
723
6
81
0.74
0.24
1.2
1.5
—
—
—
0
0
19
222
0.85
0.23
1.4
1.5
—
—
—
0
0
34
304
1.12
0.23
4.8
4.0
38.2
68.9
mg/l
0.79
27
246
438
4283
1.04
0.22
2.0
2.0
102.3
96.3
pmol/l
1.47
220
2118
18
153
1.18
0.22
1.0
1.1
88.6
107.1
iu/ml
—
9
33
36
399
0.90
0.22
2.4
2.2
—
—
—
0
0
36
399
0.90
0.22
2.4
2.2
3.8
3.7
g/l
0.15
21
295
36
399
0.90
0.22
2.4
2.2
7.7
7.5
g/l
0.20
22
310
19
163
1.17
0.21
1.2
1.1
0.1
1.6
u/ml
—
9
60
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
97
916
1.06
0.21
8.5
7.3
122.2
120.0
g/l
0.62
92
890
0
12
0.00
0.21
0.0
1.2
—
11.7
—
0
12
0
12
0.00
0.21
0.0
1.0
—
0.1
—
0
7
34
306
1.11
0.21
4.8
4.0
30.1
43.8
mg/l
0.66
27
249
229
2215
1.04
0.21
4.8
4.4
1.0
1.0
kg/l
0.11
46
329
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
63
586
1.08
0.20
1.7
1.6
—
—
—
0
0
17
145
1.17
0.20
1.7
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
6
49
1.23
0.20
1.0
1.4
—
—
—
0
0
6
50
1.20
0.19
2.5
2.0
—
464.0
—
0
5
6
50
1.20
0.19
1.2
1.1
—
—
—
0
0
34
375
0.90
0.19
2.5
2.3
2.7
3.1
g/l
1.69
22
301
12
99
1.21
0.19
1.4
1.2
—
—
—
0
0
6
51
1.18
0.19
2.0
1.5
—
—
—
0
0
6
51
1.18
0.19
2.0
1.5
—
—
—
0
0
6
51
1.18
0.19
2.0
1.5
—
—
—
0
0
6
51
1.18
0.19
2.0
1.5
—
—
—
0
0
23
203
1.14
0.19
1.3
1.3
—
—
—
0
0
18
156
1.16
0.18
1.4
1.5
—
—
—
0
0
33
363
0.91
0.18
5.0
3.9
1.3
1.4
mmol/l
0.05
33
356
15
128
1.17
0.18
1.2
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
300
1.10
0.18
2.1
2.6
0.3
0.4
u/ml
0.19
20
167
29
320
0.90
0.17
1.2
1.2
—
—
—
0
0
338
3307
1.03
0.17
3.1
3.0
32.1
31.4
u/l
0.13
313
3154
34
371
0.91
0.16
2.5
2.3
9.3
10.4
g/l
0.58
23
324
30
273
1.10
0.16
1.2
1.2
—
—
—
0
0
11
92
1.20
0.16
2.6
2.1
—
—
—
0
0
8
72
1.11
0.16
1.0
1.5
10.3
11.7
umol/l
—
8
66
29
318
0.91
0.16
1.2
1.2
—
—
—
0
0
8
73
1.10
0.15
1.1
1.1
—
—
—
0
0
12
102
1.18
0.15
1.2
1.8
—
—
—
0
0
7
86
0.81
0.14
1.6
1.1
—
61.9
—
0
8
12
139
0.86
0.14
1.2
1.6
—
—
—
0
0
117
1129
1.04
0.13
1.7
1.7
—
—
—
0
0
17
151
1.13
0.13
1.1
1.5
—
—
—
0
0
35
325
1.08
0.13
1.5
1.4
267.0
295.4
ug/g
0.35
21
186
9
109
0.82
0.13
4.3
6.4
14.2
12.2
mg/l
—
9
103
41
384
1.07
0.13
1.3
1.8
2.0
2.5
mg/l
0.33
22
275
114
1107
1.03
0.10
7.9
6.7
12.3
12.2
kpa
0.03
109
1064
114
1107
1.03
0.10
7.9
6.7
5.1
5.1
kpa
0.10
109
1063
117
1138
1.03
0.09
1.7
1.8
—
—
—
0
0
5
47
1.06
0.09
1.2
1.3
—
—
—
0
0
31
291
1.07
0.09
1.3
1.2
36.2
2.3
u/ml
—
5
31
13
145
0.90
0.09
1.2
1.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.3
—
—
—
0
0
5
48
1.04
0.09
2.2
2.1
44.9
188.7
ug/l
—
5
41
5
48
1.04
0.09
1.0
1.2
—
—
—
0
0
11
97
1.14
0.09
4.6
3.7
—
—
—
0
0
26
243
1.07
0.08
1.4
1.7
15334.7
13332.1
e6/l
0.11
17
184
12
107
1.12
0.08
1.1
1.6
—
—
—
0
0
5
62
0.81
0.08
1.0
1.2
—
—
—
0
0
33
348
0.95
0.08
1.4
1.5
—
—
—
0
0
23
246
0.93
0.08
2.2
2.3
30.5
106.7
ug/min
1.73
12
145
929
9253
1.02
0.08
15.2
15.0
39.7
39.3
%
0.85
624
6559
13
143
0.91
0.07
1.1
1.1
—
—
—
0
0
7
85
0.82
0.07
1.6
1.1
—
43.4
—
0
5
10
89
1.12
0.07
1.6
1.3
19440.0
110494.4
e6/l
—
5
48
8
91
0.88
0.06
1.8
1.5
—
—
—
0
0
8
91
0.88
0.06
1.8
1.5
—
—
—
0
0
8
91
0.88
0.06
1.8
1.5
—
—
—
0
0
9
103
0.87
0.06
1.6
1.5
—
—
—
0
0
154
1515
1.02
0.06
1.9
1.9
29.0
29.5
s
0.58
147
1467
25
237
1.06
0.05
1.2
1.6
—
—
—
0
0
80
819
0.98
0.05
3.1
2.5
68.7
66.5
ml/min/173m2
0.20
39
347
23
242
0.95
0.05
1.4
1.6
448.4
925.6
e6/l
0.40
23
197
86
843
1.02
0.05
2.3
2.4
4.9
7.1
ug/l
0.74
68
733
31
298
1.04
0.04
1.3
1.2
3.5
8.1
u/ml
—
6
50
18
170
1.06
0.04
1.1
1.5
—
—
—
0
0
13
139
0.93
0.03
1.1
1.6
—
—
—
0
0
276
2776
0.99
0.02
3.0
2.9
0.4
0.5
e6/l
0.12
210
2088
17
162
1.05
0.02
1.3
1.2
299.7
262.0
u/ml
—
9
92
24
232
1.04
0.02
2.0
1.5
—
—
—
0
0
27
278
0.97
0.02
1.3
1.4
—
—
—
0
0
26
267
0.97
0.01
1.4
1.2
—
—
—
0
0
28
273
1.03
0.01
1.2
1.4
489.2
500.8
mg/l
0.08
28
260
82
827
0.99
0.01
2.0
1.7
—
—
—
0
0
12
114
1.05
0.00
1.0
1.1
—
—
—
0
0
110
1106
0.99
0.00
8.1
6.7
1.2
1.3
mmol/l
0.08
94
877
33
328
1.01
0.00
1.6
1.7
—
—
—
0
0
12
121
0.99
0.00
1.0
1.1
—
—
—
0
0
49
492
1.00
0.00
1.4
1.8
—
—
—
0
0
23
231
1.00
0.00
1.3
1.6
—
—
—
0
0
15
153
0.98
0.00
1.2
1.2
11.7
4.9
u/ml
—
6
57
32
325
0.98
0.00
1.9
1.8
—
—
—
0
0
22
215
1.02
0.00
1.8
1.7
—
—
—
0
0
17
175
0.97
0.00
1.4
1.6
—
—
—
0
0
18
175
1.03
0.00
1.3
1.2
—
—
—
0
0
11
115
0.96
0.00
1.5
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
4.2
—
—
—
0
0
15
150
1.00
0.00
1.2
1.2
10.2
1.6
u/ml
—
5
41
5
51
0.98
0.00
1.4
4.6
—
37.1
—
0
8
0
5
0.00
0.00
0.0
1.2
—
1.0
—
0
5
0
6
0.00
0.00
0.0
1.0
—
2.5
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
7
70
1.00
0.00
1.1
1.1
269.3
223.3
mg/l
—
7
61
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
21
210
1.00
0.00
1.7
1.9
135.0
127.5
g/l
0.73
16
154
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_THYROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_THYROID | 0.943 [0.83, 1.06] | 0.343 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 3924 females with CD2_BENIGN_THYROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_THYROID | 1.195 [1.01, 1.42] | 0.042 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 1134 males with CD2_BENIGN_THYROID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_THYROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.091% | 0.186% |
| 5 | 0.58% | 1.233% |
| 10 | 1.361% | 3.105% |
| 15 | 2.586% | 5.841% |
| 20 | 4.419% | 10.295% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_THYROID – Benign neoplasm of thyroid gland
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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