Infections of breast associated with childbirth

O15_BIRTH_BREAT_INFECT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O91
  • Hospital discharge: ICD-9 675
  • Hospital discharge: ICD-8 6780[12]
  • Cause of death: ICD-10 O91
  • Cause of death: ICD-9 675
  • Cause of death: ICD-8 6780[12]

2 out of 7 registries used, show all original rules.

1471

4. Check minimum number of events

None

1471

5. Include endpoints

None

1471

6. Filter based on genotype QC (FinnGen only)

1471

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Infectiones mammae ad partum adjunctae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10532 10532 -
Only index persons 10346 10346 -
Unadjusted period prevalence (%)
Whole population 0.30 0.30 -
Only index persons 0.38 0.38 -
Median age at first event (years)
Whole population - 29.31 -
Only index persons - 29.30 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1471 1471 -
Unadjusted period prevalence (%) 0.50 0.50 -
Median age at first event (years) 29.71 29.71 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1295
Matched controls
12950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
246.9
323.0
747
71
O91.1
ICD-10 Finland
Abscess of breast associated with childbirth
455.1
164.4
161
*
67801
ICD-8 Finland
Mastitis and other disorders of lactation, Mastitis
+∞
161.9
152
*
6752A
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Nonpurulent mastitis
+∞
158.7
149
*
N61
ICD-10 Finland
Inflammatory disorders of breast
7.7
78.5
194
289
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
2.5
55.0
704
4145
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.7
53.4
506
2502
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.5
48.1
514
2682
6759X
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Unspecified infection of the breast and nipple
+∞
47.2
45
*
O85
ICD-10 Finland
Puerperal sepsis
222.1
42.1
43
*
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.2
41.7
718
4635
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.4
41.7
495
2677
O91.0
ICD-10 Finland
Infection of nipple associated with childbirth
420.4
41.4
41
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.3
38.2
452
2417
W94
ICPC
Puerperal mastitis
12.3
37.7
69
59
SPAT1380
SPAT
Postpartum check-up
2.4
36.1
364
1785
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
190.2
35.9
37
*
SPAT1197
SPAT
Extensive health check-up of expecting family
2.2
35.0
451
2490
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
2.5
34.3
311
1434
SPAT1379
SPAT
Health check-up of pregnant person
2.3
33.7
403
2140
W78
ICPC
Pregnancy
2.1
32.0
490
2891
MAX99
NOMESCO Finland
Assistance to normal delivery
2.4
31.3
328
1620
J01DB01
ATC
cefalexin; oral
2.4
29.4
1126
9489
6751A
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Abscess of breast
+∞
28.2
27
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.2
27.3
320
1655
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.3
26.7
275
1336
WX307
NOMESCO Finland
Obstetric epidural analgesia
2.3
26.5
278
1361
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.1
26.0
385
2197
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.2
25.6
298
1530
Z37.0
ICD-10 Finland
Single live birth
2.2
23.9
298
1571
6758X
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Other specified infections of the breast and nipple
+∞
20.9
20
*
O99.80
ICD-10 Finland
The fear of childbirth
2.6
20.3
161
674
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
+∞
19.8
19
*
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
2.0
19.3
310
1794
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.9
17.8
289
1674
O91
ICD-10 Finland
Infections of breast associated with childbirth
42.6
17.3
21
5
Z3232
NOMESCO Finland
Midwife
2.0
16.9
261
1480
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
24.8
16.0
22
9
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
2.5
15.9
131
557
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.9
15.5
244
1388
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
2.0
14.3
187
989
O86.8
ICD-10 Finland
Other specified puerperal infections
+∞
13.6
13
*
W19
ICPC
Lactation symptom/complaint
7.6
13.2
30
40
J01DA01
ATC
[U] cefalexin; systemic
1.6
13.2
810
6690
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.9
12.9
223
1304
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.3
12.8
127
595
SPAT1196
SPAT
Monitoring of normal pregnancy
1.9
12.5
201
1149
MA3AE
NOMESCO Finland
Combined first trimester screening
2.1
12.2
148
759
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
12.0
557
4270
SPAT1200
SPAT
Guidance for breast-feeding and breast care
2.5
12.0
92
377
Z39.1
ICD-10 Finland
Care and examination of lactating mother
3.0
12.0
68
232
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.1
11.8
132
651
P01AB01
ATC
metronidazole; oral, rectal
1.5
11.7
548
4203
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.1
11.6
137
691
ZXD05
NOMESCO Finland
Urgent procedure
1.6
11.3
412
2978
O92.7
ICD-10 Finland
Other and unspecified disorders of lactation
110.9
10.4
11
*
67802
ICD-8 Finland
Mastitis and other disorders of lactation, Abscessus mammae
+∞
10.4
10
*
W90
ICPC
Uncompl labour/delivery livebirth
2.0
10.2
137
728
J01CF02
ATC
cloxacillin; systemic
5.2
10.0
30
59
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.9
9.8
142
780
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.7
9.3
226
1459
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
9.1
383
2831
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.7
8.9
207
1321
G02CB01
ATC
bromocriptine; systemic
2.9
8.9
52
184
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
1.9
8.8
140
794
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.6
488
3823
TMA00
NOMESCO Finland
Episiotomy
2.1
8.5
91
440
67000
ICD-8 Finland
Sepsis of childbirth and the puerperium, Endometritis
+∞
8.3
8
*
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
2.6
8.2
59
235
O90.1
ICD-10 Finland
Disruption of perineal obstetric wound
33.6
8.1
10
*
O86.3
ICD-10 Finland
Other genitourinary tract infections following delivery
45.2
7.7
9
*
Z36.8
ICD-10 Finland
Other antenatal screening
2.5
7.7
57
233
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
1.9
7.6
119
670
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.6
7.6
231
1574
HAA00
NOMESCO Finland
Incision of mammary gland
18.5
7.6
11
6
ZXE00
NOMESCO Finland
One hour or less
1.4
7.6
487
3880
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
1.9
7.5
107
585
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
6.5
7.4
18
28
9731
FHL
Opening and channeling of the inflammatory site in the operating room or anesthesia
13.4
7.4
12
9
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
2.2
7.3
71
330
6700A
ICD-9 Finland
Major puerperal infection
+∞
7.3
7
*
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
2.7
7.2
47
179
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.4
7.1
56
235
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
2.8
7.1
45
167
W29
ICPC
Pregnancy symptom/complaint other
2.1
7.0
78
385
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
2.7
6.8
44
166
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.8
509
4149
X21
ICPC
Breast sympt/compl female other
2.7
6.8
44
168
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.1
6.7
69
333
O81.4
ICD-10 Finland
Vacuum extractor delivery
1.7
6.6
139
863
W84
ICPC
Pregnancy high risk
1.9
6.4
96
536
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
3.2
6.4
31
99
J02AC01
ATC
fluconazole; systemic
1.3
6.1
643
5505
J01CF01
ATC
dicloxacillin; systemic
8.6
6.1
12
14
W95
ICPC
Breast dis in pregn/puerperium other
10.1
6.0
11
11

Mortality – FinRegistry

Association

Association between endpoint O15_BIRTH_BREAT_INFECT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_BIRTH_BREAT_INFECT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_BIRTH_BREAT_INFECT – Infections of breast associated with childbirth

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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