Infections of breast associated with childbirth

O15_BIRTH_BREAT_INFECT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O91
  • Hospital discharge: ICD-9 675
  • Hospital discharge: ICD-8 6780[12]
  • Cause of death: ICD-10 O91
  • Cause of death: ICD-9 675
  • Cause of death: ICD-8 6780[12]

2 out of 7 registries used, show all original rules.

1471

4. Check minimum number of events

None

1471

5. Include endpoints

None

1471

6. Filter based on genotype QC (FinnGen only)

1471

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Infectiones mammae ad partum adjunctae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10532 10532 -
Only index persons 10346 10346 -
Unadjusted period prevalence (%)
Whole population 0.30 0.30 -
Only index persons 0.38 0.38 -
Median age at first event (years)
Whole population - 29.31 -
Only index persons - 29.30 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1471 1471 -
Unadjusted period prevalence (%) 0.50 0.50 -
Median age at first event (years) 29.71 29.71 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1295
Matched controls
12950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
246.9
323.0
747
71
O91.1
ICD-10 Finland
Abscess of breast associated with childbirth
455.1
164.4
161
*
67801
ICD-8 Finland
Mastitis and other disorders of lactation, Mastitis
+∞
161.9
152
*
6752A
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Nonpurulent mastitis
+∞
158.7
149
*
N61
ICD-10 Finland
Inflammatory disorders of breast
7.7
78.5
194
289
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
2.5
55.0
704
4145
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.7
53.4
506
2502
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
2.5
48.1
514
2682
6759X
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Unspecified infection of the breast and nipple
+∞
47.2
45
*
O85
ICD-10 Finland
Puerperal sepsis
222.1
42.1
43
*
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.2
41.7
718
4635
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.4
41.7
495
2677
O91.0
ICD-10 Finland
Infection of nipple associated with childbirth
420.4
41.4
41
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.3
38.2
452
2417
W94
ICPC
Puerperal mastitis
12.3
37.7
69
59
SPAT1380
SPAT
Postpartum check-up
2.4
36.1
364
1785
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
190.2
35.9
37
*
SPAT1197
SPAT
Extensive health check-up of expecting family
2.2
35.0
451
2490
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
2.5
34.3
311
1434
SPAT1379
SPAT
Health check-up of pregnant person
2.3
33.7
403
2140
W78
ICPC
Pregnancy
2.1
32.0
490
2891
MAX99
NOMESCO Finland
Assistance to normal delivery
2.4
31.3
328
1620
J01DB01
ATC
cefalexin; oral
2.4
29.4
1126
9489
6751A
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Abscess of breast
+∞
28.2
27
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.2
27.3
320
1655
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.3
26.7
275
1336
WX307
NOMESCO Finland
Obstetric epidural analgesia
2.3
26.5
278
1361
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.1
26.0
385
2197
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.2
25.6
298
1530
Z37.0
ICD-10 Finland
Single live birth
2.2
23.9
298
1571
6758X
ICD-9 Finland
Infections of the breast and nipple associated with childbirth, Other specified infections of the breast and nipple
+∞
20.9
20
*
O99.80
ICD-10 Finland
The fear of childbirth
2.6
20.3
161
674
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
+∞
19.8
19
*
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
2.0
19.3
310
1794
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.9
17.8
289
1674
O91
ICD-10 Finland
Infections of breast associated with childbirth
42.6
17.3
21
5
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
24.8
16.0
22
9
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
2.5
15.9
131
557
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.9
15.5
244
1388
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
2.0
14.3
187
989
O86.8
ICD-10 Finland
Other specified puerperal infections
+∞
13.6
13
*
W19
ICPC
Lactation symptom/complaint
7.6
13.2
30
40
J01DA01
ATC
[U] cefalexin; systemic
1.6
13.2
810
6690
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.9
12.9
223
1304
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.3
12.8
127
595
SPAT1196
SPAT
Monitoring of normal pregnancy
1.9
12.5
201
1149
MA3AE
NOMESCO Finland
Combined first trimester screening
2.1
12.2
148
759
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
12.0
557
4270
SPAT1200
SPAT
Guidance for breast-feeding and breast care
2.5
12.0
92
377
Z39.1
ICD-10 Finland
Care and examination of lactating mother
3.0
12.0
68
232
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.1
11.8
132
651
P01AB01
ATC
metronidazole; oral, rectal
1.5
11.7
548
4203
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.1
11.6
137
691
O92.7
ICD-10 Finland
Other and unspecified disorders of lactation
110.9
10.4
11
*
67802
ICD-8 Finland
Mastitis and other disorders of lactation, Abscessus mammae
+∞
10.4
10
*
W90
ICPC
Uncompl labour/delivery livebirth
2.0
10.2
137
728
J01CF02
ATC
cloxacillin; systemic
5.2
10.0
30
59
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.9
9.8
142
780
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.7
9.3
226
1459
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
9.1
383
2831
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.7
8.9
207
1321
G02CB01
ATC
bromocriptine; systemic
2.9
8.9
52
184
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
1.9
8.8
140
794
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.6
488
3823
TMA00
NOMESCO Finland
Episiotomy
2.1
8.5
91
440
67000
ICD-8 Finland
Sepsis of childbirth and the puerperium, Endometritis
+∞
8.3
8
*
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
2.6
8.2
59
235
O90.1
ICD-10 Finland
Disruption of perineal obstetric wound
33.6
8.1
10
*
O86.3
ICD-10 Finland
Other genitourinary tract infections following delivery
45.2
7.7
9
*
Z36.8
ICD-10 Finland
Other antenatal screening
2.5
7.7
57
233
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
1.9
7.6
119
670
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.6
7.6
231
1574
HAA00
NOMESCO Finland
Incision of mammary gland
18.5
7.6
11
6
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
1.9
7.5
107
585
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
6.5
7.4
18
28
9731
FHL
Opening and channeling of the inflammatory site in the operating room or anesthesia
13.4
7.4
12
9
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
2.2
7.3
71
330
6700A
ICD-9 Finland
Major puerperal infection
+∞
7.3
7
*
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
2.7
7.2
47
179
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.4
7.1
56
235
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
2.8
7.1
45
167
W29
ICPC
Pregnancy symptom/complaint other
2.1
7.0
78
385
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
2.7
6.8
44
166
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.8
509
4149
X21
ICPC
Breast sympt/compl female other
2.7
6.8
44
168
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.1
6.7
69
333
O81.4
ICD-10 Finland
Vacuum extractor delivery
1.7
6.6
139
863
W84
ICPC
Pregnancy high risk
1.9
6.4
96
536
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
3.2
6.4
31
99
J02AC01
ATC
fluconazole; systemic
1.3
6.1
643
5505
J01CF01
ATC
dicloxacillin; systemic
8.6
6.1
12
14
W95
ICPC
Breast dis in pregn/puerperium other
10.1
6.0
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
295
1552
2.13
26.87
1.5
1.4
—
—
—
0
0
245
1226
2.20
25.23
1.5
1.4
—
—
—
0
0
533
3519
1.81
24.42
1.8
1.7
—
—
—
0
0
590
4069
1.75
22.92
2.0
1.7
—
—
—
0
0
345
2050
1.89
21.79
2.5
2.1
—
—
—
0
0
201
1009
2.15
20.30
1.5
1.4
—
—
—
0
0
199
1004
2.14
19.82
1.5
1.4
—
—
—
0
0
332
2008
1.84
19.59
2.9
3.6
—
—
—
0
0
202
1033
2.11
19.40
1.6
1.5
—
—
—
0
0
791
6166
1.61
17.59
4.3
3.8
—
—
—
0
0
122
554
2.31
15.64
1.2
1.1
—
—
—
0
0
621
4816
1.50
12.57
2.2
2.0
—
—
—
0
0
102
487
2.18
11.60
1.9
2.1
3.9
4.4
umol/l
0.44
64
348
601
4701
1.47
11.30
2.2
1.8
—
—
—
0
0
493
3810
1.44
9.44
1.9
1.9
—
—
—
0
0
729
6065
1.40
9.09
3.9
3.8
6.1
6.2
mmol/l
0.61
634
5396
1344
12583
1.79
9.01
11.0
9.7
22.6
18.3
mg/l
4.26
1092
9631
997
8785
1.42
8.70
4.5
3.8
—
—
—
0
0
375
2818
1.44
8.15
1.9
1.9
—
—
—
0
0
1280
11990
1.52
6.72
9.3
9.2
3.9
3.9
mmol/l
3.69
1254
11613
1277
11958
1.51
6.69
9.3
9.1
139.7
139.5
mmol/l
1.65
1254
11612
426
3473
1.32
5.26
2.6
2.3
—
—
—
0
0
1395
13442
1.73
5.22
10.6
9.1
—
—
—
0
0
1454
14236
2.85
4.82
16.2
14.7
260.1
269.6
e9/l
8.28
1440
13968
1454
14242
2.81
4.70
16.1
14.6
89.9
90.1
fl
0.77
1449
14114
1454
14244
2.80
4.66
16.1
14.6
29.9
30.0
pg
0.71
1449
14114
1454
14246
2.79
4.62
16.2
14.7
6.7
6.7
e9/l
0.07
1440
13951
1454
14246
2.79
4.62
16.1
14.7
4.4
4.5
e12/l
2.68
1441
13964
184
1345
1.42
4.50
1.6
1.8
—
—
—
0
0
1454
14254
2.74
4.46
16.3
14.7
131.8
133.0
g/l
4.65
1449
14125
400
3314
1.28
4.24
2.4
2.3
54.6
54.2
u/l
0.10
378
3076
801
7212
1.24
4.09
3.1
2.9
59.0
61.6
ug/l
0.19
763
6836
377
3117
1.28
4.04
2.7
2.5
17.6
24.5
ng/l
0.73
144
1302
709
6307
1.24
4.02
3.3
3.1
0.0
0.0
estimate
0.35
144
1272
44
232
1.92
4.00
2.7
2.7
—
—
—
0
0
709
6328
1.23
3.83
4.7
4.3
0.0
0.0
estimate
0.50
141
1318
455
3892
1.24
3.60
3.3
3.1
51.2
58.6
e6/l
0.15
295
2454
710
6391
1.21
3.37
3.3
3.2
0.0
0.0
estimate
1.06
143
1293
136
999
1.40
3.27
2.1
2.1
27.9
36.7
u/l
2.58
123
834
6
7
8.60
3.26
8.8
5.7
—
—
—
0
0
157
1184
1.36
3.22
2.0
2.3
7.9
5.3
umol/l
0.73
124
985
38
209
1.84
3.10
1.3
1.3
—
—
—
0
0
958
8918
1.21
3.09
3.6
3.6
8.9
9.4
mm/h
0.79
913
8379
373
3175
1.23
3.02
4.3
5.1
1.1
1.1
inr
0.39
123
1112
596
5323
1.20
2.95
2.0
1.9
—
—
—
0
0
24
115
2.10
2.89
3.0
3.2
—
—
—
0
0
231
1878
1.27
2.79
2.5
2.4
518.5
526.7
mosm/kgh2o
0.19
198
1598
904
8415
1.19
2.74
6.5
6.3
71.3
72.0
u/l
0.21
865
7941
1275
12286
1.28
2.70
11.3
10.5
39.4
39.5
%
0.46
1047
10148
116
863
1.37
2.63
3.2
3.0
—
—
—
0
0
161
1269
1.30
2.48
1.6
1.5
—
—
—
0
0
425
3746
1.19
2.34
3.0
2.7
—
—
—
0
0
234
1949
1.24
2.30
2.2
2.3
83.3
89.2
ug/g
0.18
175
1524
589
5351
1.17
2.23
5.5
4.9
9.4
9.4
umol/l
0.01
553
5023
247
2080
1.23
2.19
2.3
2.3
7.9
9.6
e6/l
0.89
218
1825
310
2670
1.20
2.19
3.0
3.4
1.0
1.0
kg/l
0.03
50
423
28
158
1.79
2.18
1.7
1.3
—
—
—
0
0
341
2978
1.19
2.06
1.4
1.4
2.0
2.1
g/l
0.54
205
1933
386
3408
1.18
2.06
3.2
3.4
0.0
0.0
estimate
1.34
143
1308
328
2869
1.18
1.95
1.8
1.7
1.2
0.8
mg/l
1.08
245
2106
269
2315
1.20
1.92
1.5
1.5
—
—
—
0
0
274
2363
1.20
1.91
2.9
2.6
—
—
—
0
0
399
3553
1.17
1.90
1.3
1.3
1.6
1.4
u/ml
0.15
107
1012
169
1392
1.24
1.86
1.3
1.3
28.6
24.2
iu/l
0.86
150
1194
151
1235
1.25
1.78
1.1
1.2
—
—
—
0
0
318
2796
1.18
1.77
3.1
3.2
—
—
—
0
0
18
95
1.91
1.75
1.6
1.4
—
—
—
0
0
1125
10826
1.17
1.75
4.7
4.4
14.2
14.3
pmol/l
0.76
1060
10223
25
147
1.71
1.74
2.7
1.9
17.0
17.0
%
0.02
11
67
18
98
1.85
1.62
1.2
1.5
—
—
—
0
0
12
56
2.15
1.61
1.1
2.0
—
—
—
0
0
42
287
1.48
1.61
3.5
2.7
1.3
1.3
%
0.09
42
287
172
1444
1.22
1.60
2.6
2.4
6.4
4.5
e6/l
0.72
97
704
56
405
1.40
1.59
2.3
2.8
5.1
5.1
kpa
0.05
51
380
18
99
1.83
1.57
2.2
1.6
91.8
91.4
%
0.17
18
99
107
854
1.27
1.57
1.3
1.3
—
—
—
0
0
1246
12118
1.18
1.56
5.3
5.0
1.7
2.0
mu/l
0.97
1193
11569
309
2746
1.16
1.50
2.9
2.5
—
—
—
0
0
55
402
1.38
1.49
2.3
2.8
7.4
7.4
ph
—
9
52
23
139
1.67
1.48
1.2
1.7
—
—
—
0
0
9
37
2.44
1.48
1.1
1.1
—
—
—
0
0
27
414
0.65
1.46
1.3
2.4
—
—
—
0
0
7
154
0.45
1.43
3.6
6.1
384.0
386.1
umol/l
—
7
131
67
869
0.76
1.41
1.3
1.3
—
—
—
0
0
21
126
1.68
1.40
4.5
3.3
40.0
54.4
u/ml
0.24
21
126
334
3005
1.14
1.37
3.0
2.7
44.1
86.0
e6/l
0.66
258
2220
5
17
2.95
1.36
1.4
1.3
—
—
—
0
0
36
252
1.44
1.27
2.9
6.8
1.2
1.1
mmol/l
0.19
31
218
177
1527
1.18
1.26
2.7
2.7
34.3
259.5
ng/l
2.59
73
770
19
115
1.66
1.25
1.5
1.2
—
—
—
0
0
20
123
1.63
1.24
1.1
1.0
0.4
0.3
u/ml
—
5
18
142
1204
1.20
1.24
3.7
3.1
—
—
—
0
0
21
131
1.61
1.24
1.4
1.3
—
—
—
0
0
183
1587
1.17
1.23
2.5
2.2
10156.8
6015.1
u/l
0.82
82
678
131
1105
1.20
1.21
3.7
3.3
4.4
4.6
pmol/l
1.27
118
987
244
2168
1.15
1.20
1.6
1.5
—
—
—
0
0
66
835
0.78
1.18
3.3
4.1
0.0
0.5
%
0.55
12
157
301
2721
1.13
1.15
3.0
2.6
0.2
0.3
e6/l
1.41
230
1982
1335
13120
1.19
1.15
8.2
8.1
22.9
23.2
u/l
0.26
1312
12751
12
65
1.85
1.13
1.9
2.0
—
—
—
0
0
107
892
1.22
1.13
1.2
1.2
—
—
—
0
0
17
104
1.64
1.09
6.6
2.2
60.2
64.2
%
0.32
17
104
7
139
0.50
1.09
1.0
1.1
—
—
—
0
0
103
859
1.21
1.09
1.3
1.3
245.5
235.7
miu/ml
0.10
58
442
98
814
1.22
1.08
2.5
2.3
—
—
—
0
0
70
868
0.80
1.08
3.6
4.1
0.1
0.2
%
0.65
16
188
239
2659
0.88
1.06
2.8
3.2
7.5
7.4
mmol/l
0.12
210
2315
105
882
1.21
1.04
1.4
1.3
67.7
36.7
au/ml
—
5
37
5
22
2.28
1.03
1.2
1.5
—
—
—
0
0
26
179
1.46
1.03
2.8
2.2
131.2
132.4
g/l
0.12
18
133
414
3843
1.11
1.00
1.6
1.7
99.2
99.3
pmol/l
0.00
220
2085
123
1053
1.18
1.00
1.4
1.3
217.7
192.4
u/ml
0.14
117
979
7
35
2.00
1.00
1.6
1.3
—
—
—
0
0
20
131
1.53
1.00
1.1
1.0
2.6
0.5
u/ml
—
8
32
286
2602
1.12
1.00
1.3
1.3
15.0
24.2
iu/ml
3.08
92
817
169
1485
1.16
0.99
1.2
1.2
127.9
163.1
iu/ml
0.62
66
595
69
845
0.81
0.97
3.6
3.9
1.6
0.8
%
0.52
12
157
12
69
1.75
0.96
1.9
2.0
106.8
106.6
mmol/l
0.10
12
69
12
69
1.75
0.96
1.9
2.0
3.9
3.9
mmol/l
0.13
12
69
492
4618
1.10
0.95
5.5
5.2
1.2
1.2
mmol/l
0.51
413
3853
75
907
0.82
0.94
3.6
4.1
1.7
1.0
%
0.49
18
206
287
2621
1.12
0.94
2.6
3.1
97.9
99.3
%
0.51
277
2532
52
409
1.28
0.94
2.5
1.7
—
—
—
0
0
719
6874
1.09
0.91
7.0
8.1
3.9
3.9
e9/l
0.25
649
6079
13
78
1.67
0.91
1.4
1.1
0.4
6.9
nmol/l
—
5
9
49
385
1.28
0.90
3.1
6.1
—
—
—
0
0
219
1975
1.13
0.89
1.4
1.4
597.7
573.5
titre
0.07
52
407
53
661
0.79
0.89
1.9
2.5
—
—
—
0
0
147
1292
1.15
0.88
1.3
1.4
—
—
—
0
0
174
1550
1.14
0.86
1.2
1.1
—
—
—
0
0
434
4071
1.09
0.84
5.0
4.6
1.2
1.2
mmol/l
0.74
405
3706
189
2099
0.89
0.83
3.1
3.4
777.3
396.8
mg/l
0.33
117
1322
19
129
1.48
0.83
1.1
1.1
7.6
2.6
u/ml
—
10
39
8
46
1.74
0.82
1.4
1.1
—
—
—
0
0
989
10162
0.92
0.82
3.8
4.1
36.4
37.4
mmol/mol
4.57
939
9648
10
58
1.73
0.79
1.3
1.2
—
—
—
0
0
29
216
1.35
0.79
1.0
1.0
—
—
—
0
0
8
48
1.67
0.78
1.3
2.5
11.5
11.3
%
—
8
48
429
4035
1.09
0.78
4.0
3.9
36.7
36.8
g/l
0.08
397
3758
198
2183
0.89
0.78
3.8
4.1
6.8
10.7
mg/mmol
1.16
127
1366
18
123
1.47
0.77
1.1
1.6
—
—
—
0
0
139
1232
1.14
0.76
1.3
1.3
—
—
—
0
0
175
1940
0.89
0.76
1.3
1.3
—
—
—
0
0
16
107
1.50
0.76
1.6
1.2
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
70
589
1.20
0.73
3.5
3.4
1.8
1.8
mmol/l
0.06
54
464
171
1541
1.12
0.73
1.8
2.1
13.9
14.8
umol/l
0.77
163
1409
5
25
2.00
0.72
1.0
1.1
—
—
—
0
0
5
25
2.00
0.72
1.2
1.0
—
—
—
0
0
49
398
1.24
0.72
1.2
1.2
—
—
—
0
0
10
60
1.67
0.72
1.1
1.1
151.5
171.2
iu/ml
—
10
60
1168
11458
1.09
0.71
12.9
12.3
331.9
331.9
g/l
0.04
1158
11365
30
229
1.32
0.71
4.2
3.6
3.8
4.2
e9/l
0.45
30
229
16
109
1.47
0.71
2.4
2.3
1.2
1.4
e9/l
—
5
63
62
736
0.84
0.69
1.2
1.9
—
—
—
0
0
261
2815
0.91
0.69
1.6
1.6
1.3
1.3
mmol/l
0.17
228
2470
12
77
1.56
0.68
4.3
1.8
—
—
—
0
0
55
456
1.21
0.68
3.2
2.3
—
—
—
0
0
308
2876
1.09
0.67
1.8
2.0
2.6
2.6
mg/l
0.02
259
2473
5
93
0.54
0.67
1.0
1.1
1558.6
1711.1
miu/ml
—
5
93
7
43
1.63
0.67
1.1
1.2
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
31
241
1.29
0.66
3.6
5.0
—
—
—
0
0
44
358
1.24
0.65
8.0
6.6
—
—
—
0
0
35
277
1.27
0.65
2.4
2.9
—
—
—
0
0
36
286
1.27
0.65
1.5
2.6
—
—
—
0
0
109
963
1.14
0.65
2.6
2.3
24.5
23.2
au/ml
—
9
73
30
233
1.29
0.64
4.2
3.9
55.3
57.3
%
0.43
30
233
8
127
0.63
0.64
1.1
1.2
—
—
—
0
0
37
296
1.26
0.64
1.1
1.3
3.3
3.6
mmol/l
2.26
37
275
8
129
0.62
0.64
7.8
13.0
0.5
0.6
mmol/l
—
8
115
158
1433
1.11
0.62
1.7
1.6
1094.2
1210.5
nmol/l
1.00
131
1116
11
71
1.55
0.62
8.7
3.0
—
—
—
0
0
18
130
1.39
0.61
1.0
1.0
—
—
—
0
0
8
52
1.54
0.59
1.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
18
131
1.38
0.59
2.8
2.3
1.1
1.3
mmol/l
0.36
18
126
1140
11201
1.08
0.59
12.2
11.7
13.4
13.4
%
0.18
1127
10987
0
23
0.00
0.58
0.0
4.6
—
—
—
0
0
5
88
0.57
0.56
1.0
1.8
—
—
—
0
0
98
871
1.13
0.56
1.3
1.2
—
—
—
0
0
33
266
1.25
0.55
1.2
1.3
—
—
—
0
0
703
7252
0.94
0.55
2.7
2.7
—
—
—
0
0
53
450
1.18
0.54
2.1
2.1
—
—
—
0
0
25
195
1.29
0.54
1.3
1.6
—
—
—
0
0
6
38
1.58
0.54
2.3
2.1
—
—
—
0
0
103
921
1.13
0.54
2.0
2.2
3.4
4.2
e9/l
4.31
88
794
67
582
1.16
0.53
1.6
1.6
—
—
—
0
0
18
134
1.35
0.53
4.1
2.6
24.4
24.8
mg/l
0.03
13
109
21
271
0.77
0.52
1.3
1.3
—
—
—
0
0
39
323
1.21
0.52
2.4
3.1
0.1
0.4
g/l
—
9
120
20
152
1.32
0.52
2.3
2.8
24.4
24.7
mmol/l
0.09
14
139
57
490
1.17
0.52
2.4
2.4
72.0
73.3
e9/l
0.08
44
339
96
858
1.13
0.51
2.6
2.5
10.4
10.3
g/l
0.08
86
802
11
75
1.47
0.50
1.3
1.5
—
—
—
0
0
9
65
1.39
0.50
3.7
2.7
—
—
—
0
0
44
371
1.19
0.50
1.2
1.1
0.3
1.6
u/ml
3.17
11
90
75
848
0.88
0.49
1.3
1.9
—
—
—
0
0
14
101
1.39
0.49
2.6
2.2
—
—
—
0
0
1171
11873
0.93
0.49
3.3
3.4
4.8
4.8
mmol/l
0.01
1126
11347
64
559
1.15
0.48
1.7
1.7
—
—
—
0
0
65
740
0.87
0.48
1.1
1.1
—
—
—
0
0
78
692
1.13
0.47
3.9
3.9
6.1
15.7
ug/l
0.65
60
499
14
102
1.38
0.47
4.9
2.5
—
—
—
0
0
83
740
1.13
0.47
2.4
2.3
1.6
1.7
%
0.25
74
653
265
2500
1.07
0.47
1.9
2.1
5511.0
3145.7
umol/l
0.41
240
2230
33
273
1.21
0.46
1.8
1.7
—
—
—
0
0
39
329
1.19
0.45
1.3
1.3
382.3
459.8
mg/l
1.40
39
312
22
174
1.27
0.45
4.2
2.1
—
—
—
0
0
36
302
1.20
0.44
1.1
1.1
1.3
4.4
u/ml
2.43
16
116
1168
11831
0.94
0.44
3.2
3.3
1.5
1.6
mmol/l
1.92
1123
11271
530
5482
0.95
0.44
7.8
7.5
0.0
0.0
e9/l
0.58
446
4513
45
386
1.17
0.44
1.5
1.3
3.7
2.3
u/ml
—
10
48
32
266
1.21
0.43
1.0
1.0
0.2
0.2
u/ml
—
5
57
83
921
0.90
0.42
1.3
1.9
—
—
—
0
0
33
276
1.20
0.42
1.2
1.5
—
—
—
0
0
127
1169
1.09
0.42
1.3
1.4
—
—
—
0
0
8
57
1.41
0.42
1.5
2.8
—
—
—
0
0
39
456
0.85
0.42
1.4
2.0
20.5
20.8
s
0.28
32
379
8
58
1.38
0.41
1.3
1.1
—
—
—
0
0
83
919
0.90
0.41
1.3
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
33.0
—
0
10
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
132
1219
1.09
0.41
1.3
1.3
—
—
—
0
0
8
59
1.36
0.41
1.1
1.1
—
9.2
—
0
15
0
17
0.00
0.40
0.0
1.0
—
2.7
—
0
5
150
1395
1.08
0.40
1.4
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
2.3
—
1.2
—
0
18
0
18
0.00
0.40
0.0
9.2
—
—
—
0
0
13
97
1.34
0.39
1.2
1.2
—
—
—
0
0
83
916
0.90
0.39
1.3
1.9
—
—
—
0
0
5
35
1.43
0.39
2.2
1.3
—
—
—
0
0
16
124
1.29
0.38
5.9
2.4
1.6
1.4
%
0.12
11
95
9
66
1.37
0.38
1.0
1.1
—
—
—
0
0
170
1593
1.08
0.38
2.5
2.3
2.4
2.4
mmol/l
0.13
154
1390
142
1322
1.08
0.37
1.8
1.7
—
—
—
0
0
32
271
1.18
0.37
1.0
1.0
2.4
2.7
u/ml
0.10
11
147
38
327
1.17
0.37
1.1
1.0
2.1
4.1
u/ml
0.69
16
117
17
134
1.27
0.37
4.3
2.6
39.1
30.1
mg/l
0.53
12
111
77
699
1.11
0.35
1.2
1.3
—
—
—
0
0
45
395
1.14
0.35
1.1
1.1
—
—
—
0
0
83
908
0.91
0.34
1.3
1.9
—
—
—
0
0
217
2061
1.06
0.34
1.5
1.5
473.8
51713137.0
pmol/l
2.71
188
1810
1186
11979
0.95
0.33
3.4
3.6
3.0
2.9
mmol/l
2.15
1138
11367
6
89
0.67
0.33
2.0
1.4
1.8
1.2
promille
—
6
71
42
369
1.14
0.33
1.1
1.1
0.6
1.3
u/ml
0.87
20
153
556
5415
1.04
0.33
5.1
5.5
0.7
0.7
%
0.46
523
5067
19
156
1.22
0.31
1.0
1.4
—
—
—
0
0
17
138
1.23
0.30
5.4
2.9
—
—
—
0
0
163
1542
1.06
0.30
1.2
1.2
—
—
—
0
0
7
55
1.27
0.30
1.3
1.8
145.5
129.0
nmol/l
—
7
55
1151
11393
1.05
0.30
3.2
3.4
5.5
5.6
mmol/l
2.23
1085
10725
45
401
1.13
0.29
1.2
1.3
—
—
—
0
0
146
1377
1.07
0.29
3.1
2.9
0.8
0.8
mmol/l
0.04
139
1284
10
130
0.77
0.29
1.6
1.6
—
—
—
0
0
44
392
1.13
0.29
1.1
1.1
3.4
5.3
u/ml
0.44
19
206
37
327
1.13
0.28
14.0
10.8
—
—
—
0
0
285
2954
0.96
0.27
5.6
6.3
—
—
—
0
0
15
122
1.23
0.27
1.5
1.3
—
—
—
0
0
15
122
1.23
0.27
1.5
1.3
—
—
—
0
0
15
122
1.23
0.27
1.5
1.3
—
—
—
0
0
15
122
1.23
0.27
1.5
1.3
—
—
—
0
0
8
67
1.20
0.26
1.3
1.4
—
—
—
0
0
5
72
0.69
0.26
1.2
1.4
—
—
—
0
0
33
291
1.14
0.26
1.2
1.5
233.6
1359.1
e6/l
0.65
24
239
328
3385
0.96
0.25
3.0
3.0
2.3
2.3
mmol/l
0.19
299
3077
576
5640
1.03
0.25
5.0
5.5
2.8
2.7
%
0.40
540
5265
24
207
1.16
0.25
1.2
1.1
—
—
—
0
0
33
292
1.13
0.25
1.2
1.4
11.6
19.6
e6/l
0.36
24
230
145
1378
1.06
0.24
1.8
2.1
2.6
2.5
g/l
1.16
135
1265
12
96
1.25
0.24
1.1
1.2
—
—
—
0
0
380
3697
1.04
0.24
5.4
5.5
—
—
—
0
0
19
161
1.18
0.24
1.6
2.0
—
—
—
0
0
23
199
1.16
0.23
1.2
1.1
—
—
—
0
0
49
447
1.10
0.23
2.0
2.0
9.7
5.1
ug/l
0.35
42
403
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
312
3210
0.96
0.21
3.4
3.8
—
—
—
0
0
578
5675
1.03
0.21
5.2
5.7
7.5
7.8
%
1.53
544
5350
0
11
0.00
0.21
0.0
1.9
—
329.3
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
5.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
25
220
1.14
0.21
2.8
3.4
25.0
22.1
mg/l
0.17
16
133
0
13
0.00
0.21
0.0
1.2
—
10.4
—
0
7
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
1.8
—
0
6
10
80
1.25
0.20
1.1
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
0.0
—
0
8
27
240
1.13
0.20
1.1
1.2
—
—
—
0
0
13
108
1.21
0.20
1.3
1.1
—
—
—
0
0
70
657
1.07
0.19
2.2
1.8
1.2
1.3
g/l
0.63
64
617
28
252
1.11
0.18
1.2
1.3
90.1
103.5
u/ml
—
9
57
21
237
0.88
0.17
1.0
1.1
—
—
—
0
0
5
69
0.72
0.17
1.0
1.3
5.1
6.1
u/l
—
5
59
49
456
1.08
0.17
2.6
2.0
5.6
4.4
iu/l
0.28
24
185
113
1082
1.05
0.16
1.4
1.6
299.5
299.2
mu/l
0.00
94
951
10
120
0.83
0.16
1.9
1.7
20.9
20.2
nmol/l
—
10
114
73
771
0.94
0.16
1.9
2.2
0.2
0.2
g/l
0.45
67
730
266
2727
0.97
0.16
3.5
3.3
7.4
7.4
ph
0.33
61
545
8
71
1.13
0.16
1.0
1.1
—
3.2
—
0
12
46
428
1.08
0.16
1.4
1.4
19.0
21.4
u/l
0.20
37
364
9
82
1.10
0.15
1.3
2.4
—
—
—
0
0
80
762
1.05
0.15
4.2
2.6
1.2
1.2
mmol/l
0.75
69
649
200
2056
0.97
0.14
1.3
1.4
20.7
21.1
nmol/l
0.19
179
1844
14
160
0.87
0.14
1.9
1.7
—
—
—
0
0
58
548
1.06
0.14
1.3
1.2
—
—
—
0
0
8
96
0.83
0.13
1.6
1.5
0.8
0.9
g/l
—
8
96
57
539
1.06
0.13
11.4
7.7
—
—
—
0
0
610
6032
1.02
0.12
4.9
5.5
0.0
0.0
e9/l
0.36
550
5323
608
6013
1.02
0.12
4.8
5.5
0.5
0.5
e9/l
0.17
552
5321
62
590
1.05
0.12
1.1
1.1
—
—
—
0
0
30
278
1.08
0.12
1.2
1.1
—
—
—
0
0
10
116
0.86
0.12
1.2
1.1
—
—
—
0
0
1127
11324
0.98
0.11
3.0
3.1
1.1
1.2
mmol/l
2.25
1083
10779
46
435
1.06
0.11
1.2
1.1
0.5
1.0
u/ml
1.16
16
170
30
321
0.93
0.10
1.2
1.1
—
—
—
0
0
30
321
0.93
0.10
1.2
1.1
—
—
—
0
0
19
173
1.10
0.10
3.7
4.4
26.1
94.5
u/ml
—
5
51
14
125
1.12
0.10
1.4
1.5
—
—
—
0
0
5
45
1.11
0.09
1.4
1.8
—
—
—
0
0
256
2601
0.98
0.09
1.8
1.9
132.9
151.7
u/l
0.22
242
2469
29
272
1.07
0.09
1.2
1.2
211.4
248.6
u/ml
0.37
18
181
127
1240
1.03
0.08
1.9
2.2
23.9
24.4
%
0.14
110
1050
16
175
0.91
0.08
4.8
2.8
—
—
—
0
0
598
5932
1.01
0.08
5.2
5.5
30.2
30.0
%
0.19
563
5579
509
5044
1.01
0.08
2.1
2.2
—
—
—
0
0
11
123
0.89
0.08
1.9
1.2
—
—
—
0
0
7
66
1.06
0.08
1.1
1.1
0.8
3.2
u/ml
—
7
35
256
2524
1.02
0.08
1.3
1.3
3.2
9.5
u/ml
3.99
105
1092
6
74
0.81
0.07
1.2
1.1
—
—
—
0
0
6
74
0.81
0.07
3.0
2.6
—
—
—
0
0
79
767
1.03
0.07
14.0
11.5
1.0
1.1
inr
1.44
17
139
23
245
0.94
0.07
1.0
1.3
6.5
4.5
u/ml
—
10
96
78
759
1.03
0.06
2.9
3.3
—
—
—
0
0
630
6260
1.01
0.06
4.9
5.4
2.0
2.0
e9/l
0.11
583
5664
12
132
0.91
0.06
1.3
1.4
—
—
—
0
0
44
424
1.04
0.06
1.7
1.8
—
—
—
0
0
23
243
0.95
0.05
3.9
3.8
19.9
27.2
u/ml
0.61
23
237
14
129
1.09
0.05
1.1
1.5
—
—
—
0
0
590
5869
1.01
0.05
4.8
5.3
55.9
56.4
%
0.62
559
5530
64
624
1.03
0.05
1.3
1.3
0.2
1.0
u/ml
—
7
55
12
130
0.92
0.04
1.0
1.0
—
—
—
0
0
44
427
1.03
0.04
2.6
2.7
106.6
90.4
ng/l
0.18
39
369
10
91
1.10
0.04
1.4
1.2
15.2
17.5
u/l
—
10
79
629
6263
1.01
0.04
5.0
5.7
0.2
0.2
e9/l
0.19
578
5632
122
1203
1.02
0.04
2.0
2.0
359.5
380.1
nmol/l
0.67
112
1111
14
148
0.95
0.02
1.2
1.1
—
—
—
0
0
22
212
1.04
0.02
6.2
2.6
7.4
7.4
ph
1.20
17
177
37
362
1.02
0.01
1.6
1.5
—
—
—
0
0
49
498
0.98
0.01
1.3
1.5
0.6
0.5
nmol/l
0.42
39
407
72
712
1.01
0.01
8.8
7.6
0.7
1.0
mmol/l
0.42
46
538
21
204
1.03
0.00
1.7
2.0
—
—
—
0
0
33
324
1.02
0.00
4.4
3.6
24.4
24.0
mmol/l
0.45
27
292
16
164
0.98
0.00
2.0
2.3
—
—
—
0
0
20
196
1.02
0.00
1.3
1.1
18.0
122.6
iu/ml
—
5
64
28
276
1.01
0.00
1.1
1.2
—
—
—
0
0
40
396
1.01
0.00
1.1
1.3
—
—
—
0
0
97
974
1.00
0.00
3.4
4.8
1.0
1.0
mmol/l
1.03
92
908
29
288
1.01
0.00
1.1
1.3
377.7
334.2
ug/g
0.53
13
144
60
602
1.00
0.00
1.2
1.2
13.7
11.3
u/l
0.45
54
502
45
449
1.00
0.00
1.1
1.1
—
—
—
0
0
10
97
1.03
0.00
1.0
1.1
—
—
—
0
0
11
107
1.03
0.00
1.0
1.2
—
—
—
0
0
30
297
1.01
0.00
1.1
1.3
—
1270.0
—
0
15
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
5
56
0.89
0.00
1.4
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
2.0
2.1
2314.0
1965.6
ml
—
5
48
7
79
0.89
0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
15.8
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
9
89
1.01
0.00
7.4
7.2
—
—
—
0
0
7
78
0.90
0.00
1.3
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
15.6
—
0
9
6
64
0.94
0.00
1.3
1.7
0.8
4.0
u/field
—
6
46
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
0.00
1.0
1.6
27.8
31.4
pg
—
8
88
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
171.2
—
0
9
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
9
98
0.92
0.00
1.8
1.4
8.4
9.4
umol/l
—
9
90
6
63
0.95
0.00
3.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
7
72
0.97
0.00
1.7
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint O15_BIRTH_BREAT_INFECT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_BIRTH_BREAT_INFECT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_BIRTH_BREAT_INFECT – Infections of breast associated with childbirth

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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