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Viral meningitis

Endpoint Browser PheWeb

AB1_VIRAL_MENINGITIS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A87
  • Hospital discharge: ICD-9 — 04[7]
  • Hospital discharge: ICD-8 — 04[5]
  • Cause of death: ICD-10 — A87
  • Cause of death: ICD-9 — 04[7]
  • Cause of death: ICD-8 — 04[5]

2 out of 7 registries used, show all original rules.

1443

4. Check minimum number of events

None

1443

5. Include endpoints

None

1443

6. Filter based on genotype QC (FinnGen only)

1443

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11978 5977 5953
Only index persons 11399 5736 5663
Unadjusted period prevalence (%)
Whole population 0.17 0.17 0.17
Only index persons 0.21 0.21 0.22
Median age at first event (years)
Whole population 25.37 29.38 21.26
Only index persons 25.37 29.40 21.28

-FinnGen-

Key figures

All Female Male
Number of individuals 1443 943 500
Unadjusted period prevalence (%) 0.29 0.32 0.22
Median age at first event (years) 31.44 31.34 31.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1331
Matched controls
13309
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A87.9
ICD-10 Finland
Viral meningitis, unspecified
+∞
323.0
997
*
04599
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Aseptic meningitis, unspecified
+∞
212.3
198
*
TAB00
NOMESCO Finland
Lumbar puncture
10.7
114.6
235
262
R51.80
ICD-10 Finland
Headache
4.8
112.3
450
1270
G03.9
ICD-10 Finland
Meningitis, unspecified
121.5
74.8
80
7
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
70.4
67
*
AA1AD
NOMESCO Finland
CT of head and brain
3.4
64.7
374
1359
A87.8
ICD-10 Finland
Other viral meningitis
+∞
52.4
50
*
04597
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Suspecta
+∞
48.2
46
*
A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
45.0
43
*
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
42.9
41
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
36.9
533
3105
N02AX02
ATC
tramadol; systemic, rectal
2.0
30.1
546
3420
R51
ICD-10 Finland
Headache
3.7
27.8
130
382
R50.9
ICD-10 Finland
Fever, unspecified
2.6
27.7
228
982
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
27.6
151
501
J05AB11
ATC
valaciclovir; oral
2.5
24.1
204
889
5AB01
NOMESCO Finland
NA
+∞
23.0
22
*
N03AX16
ATC
pregabalin; oral
2.1
23.0
311
1692
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
22.9
207
933
M03BX02
ATC
tizanidine; oral
1.8
22.3
847
6589
R03AC02
ATC
salbutamol; inhalant
1.8
22.2
719
5312
N02BE01
ATC
paracetamol; systemic, rectal
2.0
21.9
1099
9363
J01AA02
ATC
doxycycline; systemic
1.8
21.1
981
8059
B34.9
ICD-10 Finland
Viral infection, unspecified
4.6
21.0
75
172
H02AB06
ATC
prednisolone; systemic
1.7
20.3
576
4044
0479X
ICD-9 Finland
Meningitis due to enterovirus, Unspecified viral meningitis
+∞
19.8
19
*
J01DB01
ATC
cefalexin; oral
1.9
19.8
1087
9315
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
19.3
499
3390
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
18.9
262
1427
G02.0*A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
18.8
18
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
39.0
18.6
23
6
A02BC02
ATC
pantoprazole; systemic
1.7
18.0
769
6000
R42
ICD-10 Finland
Dizziness and giddiness
2.0
17.8
253
1391
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
17.6
591
4302
J01FA10
ATC
azithromycin; systemic
1.7
17.1
826
6619
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
16.7
16
*
N03AX12
ATC
gabapentin; oral
2.1
16.5
203
1047
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
16.2
446
3045
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
30.4
16.1
21
7
G44.2
ICD-10 Finland
Tension-type headache
2.1
15.7
202
1062
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.0
15.7
235
1313
32099
ICD-8 Finland
Meningitis, With no organism specified as cause
38.5
15.4
19
5
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
15.4
660
5065
J05AB01
ATC
aciclovir; systemic
1.8
15.2
279
1674
P01AB01
ATC
metronidazole; oral, rectal
1.6
14.7
508
3670
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.8
14.6
62
169
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
81.0
14.6
16
*
M01AE02
ATC
naproxen; oral, rectal
1.6
14.6
749
5974
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
14.5
485
3469
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
14.3
296
1845
N01
ICPC
Headache
2.0
13.8
180
952
04500
ICD-8 Finland
Aseptic mentingitis due to enterovirus, Coxsackie virus
+∞
13.6
13
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
13.3
677
5339
J01MA12
ATC
levofloxacin; systemic
1.9
13.3
195
1078
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
5.4
13.2
39
74
J01FA09
ATC
clarithromycin; systemic
1.6
13.1
407
2840
J01DA01
ATC
[U] cefalexin; systemic
1.5
12.9
781
6390
N71
ICPC
Meningitis/encephalitis
70.5
12.6
14
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
4.9
12.6
40
83
M01AB05
ATC
diclofenac; systemic, rectal
1.5
12.6
831
6916
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
+∞
12.5
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
12.5
302
1962
M01AE01
ATC
ibuprofen; systemic, rectal
1.9
12.4
1195
10953
M01AH05
ATC
etoricoxib; oral
1.5
12.3
722
5837
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
12.2
129
622
N06AA09
ATC
amitriptyline; systemic
2.3
11.8
116
539
N06AX11
ATC
mirtazapine; oral
1.6
11.8
381
2668
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
11.8
237
1452
J01CA04
ATC
amoxicillin; systemic
1.6
11.8
1075
9576
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
11.6
210
1244
N06AX21
ATC
duloxetine; oral
2.0
11.4
146
761
XA800
NOMESCO Finland
Neuropsychological investigation
3.0
11.2
65
226
N05BA04
ATC
oxazepam; oral
1.6
11.1
298
1985
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
11.0
369
2603
B99
ICD-10 Finland
Other and unspecified infectious diseases
5.3
10.9
32
61
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
10.8
318
2169
M25.5
ICD-10 Finland
Pain in joint
1.6
10.6
352
2474
J01FA06
ATC
roxithromycin; oral
1.5
10.6
478
3607
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
10.6
148
798
B00.4
ICD-10 Finland
Herpesviral encephalitis
110.8
10.4
11
*
G02.0*B02.1
ICD-10 Finland
Zoster meningitis
+∞
10.4
10
*
A02BC05
ATC
esomeprazole; systemic
1.5
10.3
453
3394
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
10.2
307
2100
J01FF01
ATC
clindamycin; systemic
1.6
10.2
311
2139
N05CF02
ATC
zolpidem; oral
1.7
10.1
222
1397
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
9.9
249
1626
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
9.8
65
246
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.7
226
1445
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
9.6
200
1235
ZX120
NOMESCO Finland
Intravenous
2.1
9.6
110
550
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.1
9.6
29
58
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
6.4
9.6
24
38
M54.5
ICD-10 Finland
Low back pain
1.5
9.5
406
3009
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
9.5
298
2062
N06AB04
ATC
citalopram; systemic
1.6
9.4
253
1679
A84.8
ICD-10 Finland
Other tick-borne viral encephalitis
+∞
9.4
9
*
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
9.4
9
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.1
9.3
106
527
N05CF01
ATC
zopiclone; oral
1.5
9.3
327
2316
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
9.3
108
542
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.1
9.2
98
475
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
9.1
131
714
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.7
9.1
61
233
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
8.9
164
975
ZXD05
NOMESCO Finland
Urgent procedure
1.5
8.8
373
2750
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.8
405
3043
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
8.8
107
549
C01CA24
ATC
epinephrine; parenteral
2.1
8.8
96
472
S06.0
ICD-10 Finland
Concussion
1.9
8.7
128
704
UJF32
NOMESCO Finland
Coloscopy
1.6
8.6
251
1698
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.4
8.5
39
116
R01AD09
ATC
mometasone; nasal
1.4
8.5
574
4641
A02BC03
ATC
lansoprazole; oral
1.5
8.5
297
2100
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
8.4
102
523
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
90.6
8.4
9
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
8.3
115
618
G03.2
ICD-10 Finland
Benign recurrent meningitis [Mollaret]
+∞
8.3
8
*
A87.2
ICD-10 Finland
Lymphocytic choriomeningitis
+∞
8.3
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.3
214
1401
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
8.3
107
561
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
8.3
70
306
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.2
339
2485
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
8.2
162
986
M79.6
ICD-10 Finland
Pain in limb
1.5
8.1
395
2991
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
33.5
8.1
10
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
8.1
296
2109
UKC02
NOMESCO Finland
Cystoscopy
1.8
7.8
126
717
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.8
614
5077
G43.9
ICD-10 Finland
Migraine, unspecified
2.0
7.7
97
506
R01AD08
ATC
fluticasone; nasal
1.5
7.7
354
2649
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
5.2
7.6
22
43
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
7.5
397
3045
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
7.5
174
1107
Z3231
NOMESCO Finland
Registered nurse
1.5
7.5
288
2075
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
7.5
137
814
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.5
7.5
55
223
G03.8
ICD-10 Finland
Meningitis due to other specified causes
80.5
7.4
8
*
N05BA01
ATC
diazepam; systemic, rectal
1.7
7.3
149
915
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
7.3
111
621
G03.1
ICD-10 Finland
Chronic meningitis
+∞
7.3
7
*
B02.1
ICD-10 Finland
Zoster meningitis
+∞
7.3
7
*
A87
ICD-10 Finland
Viral meningitis
+∞
7.3
7
*
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.5
7.3
54
220
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
7.3
180
1166
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
7.3
193
1270
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.3
116
660
N02AA05
ATC
oxycodone; systemic
1.8
7.2
114
646
ZXE00
NOMESCO Finland
One hour or less
1.4
7.2
461
3657
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
7.2
189
1245
32088
ICD-8 Finland
Meningitis, Alia definita
20.1
7.1
10
5
A02BC01
ATC
omeprazole; systemic
1.5
7.1
282
2039
N06AX16
ATC
venlafaxine; oral
1.6
7.1
185
1216
M48.0
ICD-10 Finland
Spinal stenosis
2.0
7.0
89
463
R4120
NOMESCO Finland
Occupational therapy
2.2
7.0
71
339
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
6.9
335
2522
WX110
NOMESCO Finland
Local anesthesy
1.4
6.9
879
7799
H53.2
ICD-10 Finland
Diplopia
3.0
6.9
38
131
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.9
686
5850
J03.9
ICD-10 Finland
Acute tonsillitis, unspecified
1.9
6.8
90
478
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
6.8
96
523
R07.3
ICD-10 Finland
Other chest pain
1.8
6.8
107
606
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
3.5
6.8
29
83
H02AB07
ATC
prednisone; oral
1.7
6.8
142
876
M79.1
ICD-10 Finland
Myalgia
1.7
6.7
156
990
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.7
912
8156
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
6.7
87
460
F43.1
ICD-10 Finland
Post-traumatic stress disorder
2.7
6.6
43
164
A02BA02
ATC
ranitidine; systemic
1.6
6.6
176
1163
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
6.6
167
1089
N06AB10
ATC
escitalopram; oral
1.5
6.6
276
2018
M70.6
ICD-10 Finland
Trochanteric bursitis
1.8
6.6
112
650
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.6
484
3920
N17
ICPC
Vertigo/dizziness
1.8
6.4
102
579
R03BA02
ATC
budesonide; inhalant
1.5
6.4
200
1370
120
Kela drug reimbursment
Hypogammaglobulinaemia
14.4
6.4
10
7
L08
ICPC
Shoulder symptom/complaint
1.6
6.3
183
1234
G44.8
ICD-10 Finland
Other specified headache syndromes
4.0
6.3
23
58
C07AA05
ATC
propranolol; systemic
1.5
6.3
230
1631
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.3
286
2124
Z2445
NOMESCO Finland
Psychologist
2.2
6.3
62
295
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.1
6.2
69
344
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
6.2
103
593
J01.1
ICD-10 Finland
Acute frontal sinusitis
3.3
6.2
28
85
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
6.1
375
2935
EMB10
NOMESCO Finland
Tonsillectomy
1.8
6.1
94
529
N02AC04
ATC
dextropropoxyphene; oral
2.9
6.1
35
122
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
6.1
103
598
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.3
6.1
53
237
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.1
6.1
67
330
M54.1
ICD-10 Finland
Radiculopathy
2.4
6.1
47
198
A41.9
ICD-10 Finland
Sepsis, unspecified
3.0
6.0
32
109

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_VIRAL_MENINGITIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_MENINGITIS 1.101 [0.92, 1.32] 0.301
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 4213 females with AB1_VIRAL_MENINGITIS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_MENINGITIS 0.997 [0.84, 1.19] 0.973
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 177 out of 4014 males with AB1_VIRAL_MENINGITIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_MENINGITIS.

N-year risk Females Males
1 0.094% 0.179%
5 0.558% 1.211%
10 1.285% 3.248%
15 2.505% 5.883%
20 4.447% 10.229%

Relationships between endpoints

↥

Index endpoint: AB1_VIRAL_MENINGITIS – Viral meningitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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