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Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO Endpoint Browser PheWeb

E4_CONGEIOD

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E00, E03.0, E03.1
  • Hospital discharge: ICD-9 — 243
  • Hospital discharge: ICD-8 — 243
  • Cause of death: ICD-10 — E00, E03.0, E03.1
  • Cause of death: ICD-9 — 243
  • Cause of death: ICD-8 — 243

2 out of 7 registries used, show all original rules.

1153

4. Check minimum number of events

None

1153

5. Include endpoints

None

1153

6. Filter based on genotype QC (FinnGen only)

1114

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11024 8810 2178
Only index persons 10110 8174 1936
Unadjusted period prevalence (%)
Whole population 0.21 0.25 0.06
Only index persons 0.26 0.30 0.07
Median age at first event (years)
Whole population 67.75 68.82 63.38
Only index persons 67.54 68.52 63.45

-FinnGen-

Key figures

All Female Male
Number of individuals 1114 898 216
Unadjusted period prevalence (%) 0.28 0.32 0.10
Median age at first event (years) 60.90 59.47 66.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1153
Matched controls
11530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
2375.4
307.7
1114
137
104
Kela drug reimbursment
Thyroid insufficiency
1994.7
307.7
473
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
307.7
931
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1042.9
307.7
800
25
T86
ICPC
Hypothyroidism/myxoedema
133.7
280.2
141
12
E03
ICD-10 Finland
Other hypothyroidism
530.9
262.8
252
6
E03.89
ICD-10 Finland
Other specified hypothyroidism
425.3
242.2
235
7
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
2535.2
208.8
196
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
67.1
158.3
87
14
H03BB01
ATC
carbimazole; oral
79.0
138.1
74
10
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
641.7
119.4
116
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
41.7
79.2
48
12
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
6.2
55.7
99
171
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
563.9
55.0
54
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
149.8
54.4
57
*
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
5.3
48.7
104
213
A10AB05
ATC
insulin aspart; parenteral
4.0
47.6
150
418
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.9
45.9
86
156
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.6
45.2
59
72
SPAT1254
SPAT
Administration of medicine
2.7
41.3
274
1189
M14.5*E03.9
ICD-10 Finland
Arthropathy in hypothyroidism (E00-E03+)
+∞
40.9
39
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
40.9
39
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.4
40.8
54
67
T89
ICPC
Diabetes insulin dependent
5.5
40.5
81
156
A10AB01
ATC
insulin (human); parenteral
5.7
38.8
75
140
A10AE05
ATC
insulin detemir; parenteral
4.1
36.6
105
272
A10AE04
ATC
insulin glargine; parenteral
3.2
36.4
160
551
J01MA12
ATC
levofloxacin; systemic
2.5
35.6
273
1263
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.4
35.0
321
1609
BAA60
NOMESCO Finland
Total thyroidectomy
185.6
34.9
36
*
C03CA01
ATC
furosemide; systemic
2.1
32.7
454
2684
A10AB04
ATC
insulin lispro; parenteral
5.5
31.8
63
120
H04AA01
ATC
glucagon; nasal, parenteral
7.0
31.2
48
71
103
Kela drug reimbursment
Diabetes, insulin-treated
2.2
30.3
349
1906
A10AA01, ,
ATC
6.0
30.0
54
94
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
29.9
353
1946
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
9.3
29.6
36
40
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
29.3
28
*
SPAT1263
SPAT
Sampling
2.0
28.5
550
3618
A10AC01
ATC
insulin (human); parenteral
3.0
28.0
136
494
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
27.9
566
3778
N03AX16
ATC
[U] pregabalin
2.2
27.6
323
1767
A02BC02
ATC
pantoprazole; systemic
2.1
27.3
819
6244
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
27.1
348
1970
E66.00
ICD-10 Finland
Metabolic syndrome
3.9
27.1
84
230
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
26.6
178
763
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.5
26.5
52
98
N05AH04
ATC
quetiapine; oral
2.3
26.4
238
1169
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.9
26.3
80
216
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
25.9
470
2999
SPAT1301
SPAT
No procedures
2.0
25.5
425
2630
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
25.5
386
2310
H02AB09
ATC
hydrocortisone; systemic
5.8
25.4
47
84
AA1AD
NOMESCO Finland
CT of head and brain
2.0
25.2
365
2150
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
25.1
24
*
N06AX11
ATC
mirtazapine; oral
1.9
24.9
438
2758
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
24.8
295
1614
SPAT1262
SPAT
Handing over of treatment supplies
2.3
24.8
234
1168
N03AX09
ATC
lamotrigine; oral
3.9
24.8
74
197
G47.3
ICD-10 Finland
Sleep apnoea
2.3
24.7
232
1156
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
24.4
243
1239
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
24.4
254
1319
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
23.8
266
1418
A10AA02, ,
ATC
4.3
23.4
62
151
R06.0
ICD-10 Finland
Dyspnoea
2.0
23.0
351
2093
N05AA02
ATC
levomepromazine; systemic
4.0
22.9
66
171
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.4
22.8
38
61
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
22.8
235
1213
R4110, ,
SPAT
2.7
22.5
126
493
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
22.3
392
2448
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.0
21.9
63
163
N05CF01
ATC
zopiclone; oral
1.9
21.9
423
2719
N06AX16
ATC
venlafaxine; oral
2.3
21.7
183
868
N06AX21
ATC
duloxetine; oral
2.4
21.6
165
749
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
21.4
127
512
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
21.3
209
1056
R53
ICD-10 Finland
Malaise and fatigue
1.9
21.2
327
1950
J01DB01
ATC
cefalexin; oral
2.1
21.1
956
7996
B03BA03
ATC
hydroxocobalamin; parenteral
3.1
21.0
90
303
N02BE01
ATC
paracetamol; systemic, rectal
2.6
21.0
1045
9074
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
22.0
20.9
30
14
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
20.8
479
3238
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
20.8
157
708
R42
ICD-10 Finland
Dizziness and giddiness
1.9
20.8
317
1879
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
20.8
493
3363
N05BA04
ATC
oxazepam; oral
1.9
20.6
348
2134
L28
ICPC
Limited function/disability (L)
2.0
20.4
260
1448
T90
ICPC
Diabetes non-insulin dependent
2.0
20.3
276
1572
ZXD05
NOMESCO Finland
Urgent procedure
1.9
20.2
386
2461
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
20.1
241
1312
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.7
20.1
66
188
K29.4
ICD-10 Finland
Chronic atrophic gastritis
4.9
20.0
44
92
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
19.8
19
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
19.8
19
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
19.8
92
325
N06AB04
ATC
citalopram; systemic
2.0
19.7
274
1572
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
18.1
19.6
30
17
N30.0
ICD-10 Finland
Acute cystitis
2.0
19.5
254
1422
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
19.5
717
5524
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
19.5
363
2290
A10AE06
ATC
insulin degludec; parenteral
4.1
19.5
54
136
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.7
19.5
107
414
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
19.0
281
1643
A28
ICPC
Limited function/disability NOS
2.0
18.9
257
1460
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
18.8
18
*
SPAT1229
SPAT
Assessment of need for aid
2.5
18.7
122
514
SPAT1216
SPAT
Assessment of functional ability
2.0
18.6
227
1240
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.9
18.6
295
1764
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
18.6
221
1197
107
Kela drug reimbursment
Pernicious anaemia
5.2
18.4
38
75
SPAT1255
SPAT
Intravenous administration of medicine
2.8
18.4
94
350
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
18.3
211
1128
N06AA09
ATC
amitriptyline; systemic
2.4
18.3
142
648
B81
ICPC
Anaemia vit B12/folate deficiency
3.6
18.2
61
176
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.4
18.1
30
48
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.6
18.0
109
443
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
18.0
104
413
J01FF01
ATC
clindamycin; systemic
1.9
17.9
317
1960
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
27.2
17.9
24
9
A06AD11
ATC
lactulose; oral
2.0
17.8
213
1154
N06AB03
ATC
fluoxetine; oral
2.2
17.6
163
800
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
96.6
17.6
19
*
R11
ICD-10 Finland
Nausea and vomiting
2.3
17.5
138
633
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
17.5
339
2152
N03AE01
ATC
clonazepam; systemic
2.9
17.5
85
308
R02
ICPC
Shortness of breath/dyspnoea
2.2
17.4
173
873
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
17.4
196
1039
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
17.4
80
281
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
17.4
185
960
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
17.3
457
3170
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
17.3
465
3244
N03AX12
ATC
[U] gabapentin; oral
2.0
17.0
208
1134
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.2
16.8
69
227
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
16.7
409
2772
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.7
16.6
93
363
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
16.6
332
2123
N02AX02
ATC
tramadol; systemic, rectal
1.7
16.6
488
3477
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.0
16.6
29
49
SPAT1097
SPAT
Recording of ECG
2.0
16.5
191
1020
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
16.5
168
856
R03AC02
ATC
salbutamol; inhalant
1.7
16.5
641
4915
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
12.4
16.4
29
24
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
16.3
245
1433
N03AG01
ATC
valproic acid; systemic, rectal
2.8
16.3
85
320
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
16.2
262
1569
SPAT1104
SPAT
Monitoring of emergency patient
2.7
16.1
88
339
A02BC05
ATC
esomeprazole; systemic
1.7
16.1
467
3308
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.3
16.0
134
630
R60.0
ICD-10 Finland
Localized oedema
2.1
16.0
166
851
UJF32
NOMESCO Finland
Coloscopy
1.8
16.0
308
1945
C07AB07
ATC
bisoprolol; oral
1.7
16.0
567
4232
A10BA02
ATC
metformin; oral
1.8
15.9
323
2070
H02AB06
ATC
prednisolone; systemic
1.7
15.9
541
3993
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
60.9
15.8
18
*
K59.1
ICD-10 Finland
Functional diarrhoea
2.7
15.8
87
337
N06AB06
ATC
sertraline; oral
2.2
15.7
141
682
N05AN01
ATC
lithium; oral
4.7
15.7
36
78
C10AA01
ATC
simvastatin; oral
1.7
15.7
484
3479
24399
ICD-8 Finland
Cretinism of congenital origin
+∞
15.7
15
*
P29
ICPC
Psychological sympt/compl other
2.6
15.6
91
363
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.9
15.5
75
271
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
15.5
333
2168
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
15.5
121
553
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
15.3
224
1297
SPAT1153
SPAT
Removal of sutures
1.7
15.3
365
2446
G44.2
ICD-10 Finland
Tension-type headache
2.0
15.3
179
960
E66.8
ICD-10 Finland
Other obesity
2.9
15.1
74
269
C10AA05
ATC
atorvastatin; oral
1.7
15.1
452
3214
R51.80
ICD-10 Finland
Headache
2.0
15.1
198
1104
E06.3
ICD-10 Finland
Autoimmune thyroiditis
45.6
15.1
18
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.2
15.0
136
660
A29
ICPC
General symptom/complaint other
2.0
15.0
170
899
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
15.0
150
757
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
3.8
15.0
46
125
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.9
15.0
27
47
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
15.0
253
1532
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
4.3
14.7
38
91
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
12.1
14.6
26
22
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
81.2
14.6
16
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
14.6
136
668
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.0
14.5
184
1014
SPAT1240
SPAT
Therapeutic discussion
2.2
14.4
129
623
N02AA05
ATC
oxycodone; systemic
1.9
14.4
226
1336
E66.01
ICD-10 Finland
Obesity due to excess calories
2.3
14.3
108
486
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.7
14.3
76
289
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.3
14.2
24
39
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
14.2
223
1318
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
14.1
61
207
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
14.0
247
1511
J01DA01
ATC
[U] cefalexin
1.6
14.0
701
5626
R50.9
ICD-10 Finland
Fever, unspecified
2.0
14.0
177
974
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
14.0
80
316
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.1
13.8
57
188
ZX120
NOMESCO Finland
Intravenous
2.2
13.7
121
581
J01MA02
ATC
ciprofloxacin; systemic
1.6
13.7
434
3111
P03
ICPC
Feeling depressed
2.2
13.6
115
542
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
13.6
575
4417
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
4.5
13.6
33
75
E66.9
ICD-10 Finland
Obesity, unspecified
3.2
13.6
54
174
E00.9
ICD-10 Finland
Congenital iodine-deficiency syndrome, unspecified
+∞
13.6
13
*
2430A
ICD-9 Finland
Congenital hypothyroidism[HYPOTHYREOSIS CONGENITA]
+∞
13.6
13
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
13.6
13
*
SPAT1260
SPAT
Consultation of another employee
1.8
13.5
219
1304
XCK10
NOMESCO Finland
Photography of fundus of eye
2.2
13.5
128
632
C09AA05
ATC
ramipril; oral
1.7
13.5
289
1869
A02BC01
ATC
omeprazole; systemic
1.7
13.3
330
2218
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
13.3
109
507
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
13.3
236
1444
P01AB01
ATC
metronidazole; oral, rectal
1.6
13.2
467
3430
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.8
13.2
69
260
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
13.1
113
537
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.2
13.0
119
580
N05BA06
ATC
lorazepam; systemic, sublingual
2.6
12.9
76
304
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
12.9
124
616
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
12.9
287
1874
M79.6
ICD-10 Finland
Pain in limb
1.6
12.8
476
3531
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
12.8
129
652
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
12.8
175
987
N06AB10
ATC
escitalopram; oral
1.8
12.7
230
1415
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
70.7
12.6
14
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
12.6
166
924
N05AH03
ATC
olanzapine; systemic
2.6
12.6
76
308
2449X
ICD-9 Finland
Acquired hypothyroidism, Unspecified hypothyroidism
+∞
12.5
12
*
UKC02
NOMESCO Finland
Cystoscopy
1.9
12.5
163
904
B01AB05
ATC
enoxaparin; parenteral
1.6
12.5
366
2563
N30.9
ICD-10 Finland
Cystitis, unspecified
2.3
12.4
100
462
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.9
12.4
59
211
N05AF03
ATC
chlorprothixene; systemic
3.9
12.4
36
94
SPAT1281
SPAT
Other administrative function
2.3
12.4
101
469
SPAT1251
SPAT
Organisation of medication
2.9
12.4
58
206
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.6
12.3
40
113
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
12.3
175
1000
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.4
12.2
87
381
E0000UV, ,
ATC
1.6
12.2
474
3545
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
12.1
140
745
N06AX03
ATC
mianserin; oral
2.6
11.9
68
268
H02AB04
ATC
methylprednisolone; systemic
1.9
11.9
174
1002
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.2
11.8
109
533
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
11.8
110
540
F32.8
ICD-10 Finland
Other depressive episodes
5.0
11.7
25
51
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
11.7
143
775
N05BA01
ATC
diazepam; systemic, rectal
1.9
11.6
162
918
M79.7
ICD-10 Finland
Fibromyalgia
3.1
11.6
49
164
P99
ICPC
Psychological disorders other
3.5
11.6
40
118
A10BK01
ATC
dapagliflozin; oral
2.5
11.6
76
321
A41.9
ICD-10 Finland
Sepsis, unspecified
2.9
11.6
53
186
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
11.2
11.6
21
19
A46
ICD-10 Finland
Erysipelas
1.9
11.6
161
912
A04
ICPC
Weakness/tiredness general
1.8
11.5
191
1143
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
11.5
98
464
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.3
11.5
93
431
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
11.5
11
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
11.5
180
1059
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
121.2
11.4
12
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.2
11.3
44
140
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.7
11.3
62
240
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.4
11.3
28
65
R5140
NOMESCO Finland
Monitoring the use of the aid
2.1
11.3
106
522
M25.5
ICD-10 Finland
Pain in joint
1.6
11.3
356
2526
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
11.2
501
3842
M01AH01
ATC
celecoxib; oral
1.7
11.2
215
1341
A05
ICPC
Feeling ill
2.3
11.2
83
370
S97
ICPC
Chronic ulcer skin
2.4
11.2
80
351
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
12.9
11.2
19
15
L03
ICPC
Low back symptom/complaint
1.6
11.1
310
2134
K02.1
ICD-10 Finland
Caries of dentine
1.5
11.1
606
4850
A02BA02
ATC
ranitidine; systemic
1.7
11.1
233
1491
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
11.0
388
2821
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.4
11.0
80
354
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
11.0
124
654
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
43.7
10.9
13
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
10.9
58
221
T82
ICPC
Obesity
3.0
10.9
48
165
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
10.9
133
721
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.3
10.9
80
356
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
12.1
10.9
19
16
XX9LA
NOMESCO Finland
Complementary kinetic X-ray examination without contrast
8.4
10.8
23
28
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
10.8
569
4508
SPAT1312
SPAT
General health counselling
1.6
10.8
356
2546
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
10.8
111
566
N05CD07
ATC
temazepam; oral
1.9
10.8
155
887
WVA30, ,
SPAT
2.6
10.7
63
252
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
10.7
202
1253
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
10.7
95
458
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
60.6
10.6
12
*
N05AX08
ATC
risperidone; systemic
2.0
10.6
113
583
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.5
10.6
66
272
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
10.6
96
466
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.1
10.6
109
556
R32
ICD-10 Finland
Unspecified urinary incontinence
3.1
10.6
43
141
H3600, E103,
ICD-10 Finland
9.3
10.5
21
23
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
3.0
10.5
47
163
SPAT1325
SPAT
Vaccination
1.5
10.5
398
2935
C07AB02
ATC
metoprolol; systemic
1.7
10.5
247
1627
D11
ICPC
Diarrhoea
1.9
10.5
140
782
M04AA01
ATC
allopurinol; systemic
1.9
10.4
139
775
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
10.4
10
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
10.4
10
*
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
10.4
10
*
N06AX26
ATC
vortioxetine; oral
2.3
10.4
80
363
C03DA01
ATC
spironolactone; oral
1.9
10.3
147
838
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
2.2
10.3
90
431
SPAT1310
SPAT
Counselling related to known health issue
1.6
10.2
353
2546
H3603, E103,
ICD-10 Finland
13.3
10.2
17
13
A10BJ06
ATC
semaglutide; parenteral
2.7
10.1
53
200
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
10.1
756
6406
AN1
HP
Coronary angiography
1.9
10.1
128
702
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.1
10.1
94
461
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.4
10.1
25
58
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.4
10.1
71
310
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.7
10.0
54
207
XF402
NOMESCO Finland
ECG with work load test
2.0
10.0
116
617
J01EA01
ATC
trimethoprim; systemic
1.5
10.0
361
2628
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
9.9
116
620
M70.6
ICD-10 Finland
Trochanteric bursitis
1.8
9.9
168
1011
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
8.2
9.8
21
26
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
9.8
261
1768
WYA20
NOMESCO Finland
Home visit
3.6
9.8
32
91
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
9.8
51
192
N06AX12
ATC
bupropion; oral
2.4
9.8
69
301
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
9.8
504
3949
RS221, ,
NOMESCO Finland
4.1
9.7
26
64
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
9.7
129
718
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.1
9.7
100
510
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
9.7
87
421
106
Kela drug reimbursment
Hypoparathyroidism
55.5
9.7
11
*
R03BA05
ATC
fluticasone; inhalant
1.7
9.7
211
1360
M54.5
ICD-10 Finland
Low back pain
1.5
9.6
387
2877
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.6
9.6
258
1750
R39.1
ICD-10 Finland
Other difficulties with micturition
3.3
9.6
36
112
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.3
9.6
35
107
N03AF02
ATC
oxcarbazepine; oral
3.0
9.6
43
149
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
9.6
471
3648
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
9.6
259
1760
N06AB05
ATC
paroxetine; oral
2.4
9.6
66
285
D09
ICPC
Nausea
2.5
9.6
61
254
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.5
9.5
58
237
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.8
9.5
46
167
Z97.4
ICD-10 Finland
Presence of external hearing-aid
2.4
9.5
66
287
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.8
9.4
47
173
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.7
9.4
51
196
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
9.4
118
645
E000001, ,
ATC
1.6
9.4
228
1509
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
9.4
9
*
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
9.4
9
*
P28
ICPC
Limited function/disability (P)
5.2
9.4
19
37
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.6
9.3
53
209
P06
ICPC
Sleep disturbance
1.9
9.3
124
691
Z00.8
ICD-10 Finland
Other general examinations
2.1
9.3
91
455
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
9.3
253
1722
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.9
9.3
115
626
MAA00
NOMESCO Finland
Amniocentesis
3.5
9.2
31
90
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
9.2
133
761
A11CC03
ATC
alfacalcidol; systemic
3.8
9.2
28
76
D07AC01
ATC
betamethasone; topical
1.5
9.2
371
2757
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.7
9.2
171
1055
Z2445
NOMESCO Finland
Psychologist
2.8
9.1
45
165
SPAT1252
SPAT
Overall medication plan or its review
2.1
9.1
87
431
F61.0
ICD-10 Finland
Mixed personality disorders
5.1
9.1
19
38
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.6
9.1
30
86
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
4.5
9.1
22
50
J01AA02
ATC
doxycycline; systemic
1.5
9.1
844
7390
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
9.1
55
224
EBA00
NOMESCO Finland
Extraction of tooth
1.5
9.0
368
2737
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
9.0
152
911
R52.9
ICD-10 Finland
Pain, unspecified
1.9
9.0
108
581
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.5
9.0
56
231
K90
ICPC
Stroke/cerebrovascular accident
2.9
9.0
41
144
XF404
NOMESCO Finland
Ambulatory ECG
2.0
9.0
103
546
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.1
9.0
85
420
Z25.1
ICD-10 Finland
Need for immunization against influenza
2.3
9.0
66
294
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.0
8.9
38
128
F60.8
ICD-10 Finland
Other specific personality disorders
18.8
8.9
13
7
C07AA05
ATC
propranolol; systemic
1.6
8.9
209
1369
A02BC03
ATC
lansoprazole; oral
1.5
8.9
322
2335
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.4
8.9
63
276
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
8.8
240
1631
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
8.8
161
987
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.8
8.8
43
157
C02AC05
ATC
moxonidine; oral
2.5
8.8
55
228
Z01.2
ICD-10 Finland
Dental examination
1.5
8.7
465
3642
H02AB07
ATC
prednisone; oral
1.7
8.7
161
990
177
Kela drug reimbursment
Insulin glargine 300 U / ml
3.9
8.7
25
65
TK800
NOMESCO Finland
Hemodialysis
3.9
8.7
25
65
C08CA01
ATC
amlodipine; oral
1.5
8.7
426
3285
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.7
188
1208
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.1
8.6
86
433
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
4.4
8.6
21
48
N05AH02
ATC
clozapine; systemic
4.4
8.6
21
48
S06.0
ICD-10 Finland
Concussion
1.8
8.6
128
738
A12AA04
ATC
calcium carbonate; oral
4.8
8.6
19
40
ZXA00
NOMESCO Finland
Right side
1.5
8.6
300
2156
WX722
NOMESCO Finland
PEEP
2.6
8.6
50
200
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
8.6
130
755
H25.8
ICD-10 Finland
Other senile cataract
1.8
8.5
147
886
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
8.5
502
4004
WZA90
NOMESCO Finland
Other medical or dental certificate
1.6
8.5
240
1645
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
8.5
121
690
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.9
8.4
24
62
RJ630, ,
NOMESCO Finland
90.7
8.4
9
*
R96
ICPC
Asthma
1.9
8.4
112
624
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.4
297
2139
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
8.4
40
144
L08
ICPC
Shoulder symptom/complaint
1.6
8.4
230
1565
S18
ICPC
Laceration/cut
1.4
8.4
472
3731
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
8.3
69
323
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.7
8.3
145
878
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
4.1
8.3
22
54
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
7.1
8.3
19
27
UJD02
NOMESCO Finland
Gastroscopy
2.3
8.2
59
260
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.3
8.2
21
50
J01CA04
ATC
amoxicillin; systemic
1.5
8.2
888
7922
R05
ICPC
Cough
1.5
8.2
264
1862
N05BA12
ATC
alprazolam; oral
1.9
8.2
113
637
SPAT1360
SPAT
Extensive global examination
2.0
8.2
84
428
N05AC02
ATC
thioridazine; oral
3.4
8.1
28
83
N04BC05
ATC
pramipexole; oral
1.9
8.1
95
508
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.6
8.1
46
182
P76
ICPC
Depressive disorder
2.2
8.0
69
328
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
8.0
316
2324
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
8.0
118
679
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
8.0
267
1897
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.9
8.0
23
60
N03AX14
ATC
levetiracetam; systemic
3.0
8.0
34
115
J01CA08
ATC
pivmecillinam; oral
1.4
8.0
554
4537
SPAT1211
SPAT
Application of soft bandage
1.9
7.9
106
592
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
13.1
7.9
13
10
SPAT1285
SPAT
Provision of consultation response
2.2
7.9
63
291
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
3.2
7.8
30
95
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.2
7.8
68
325
R81
ICPC
Pneumonia
2.6
7.8
44
173
R5110, ,
SPAT
2.0
7.8
83
428
K77
ICPC
Heart failure
3.0
7.8
33
111
SPAT1266
SPAT
Separate instruction to prepare for procedure
2.8
7.8
37
133
J02AC01
ATC
fluconazole; systemic
1.4
7.8
447
3532
WX882
NOMESCO Finland
High dependency care
2.8
7.8
38
139
N05AB03
ATC
perphenazine; systemic, rectal
2.6
7.7
43
168
SPAT1167
SPAT
Insertion of urinary catheter
2.7
7.7
40
151
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
7.7
86
452
A07AA02
ATC
nystatin; oral
2.0
7.7
77
389
A10BB12
ATC
glimepiride; oral
2.0
7.7
84
438
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
7.7
156
984
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
2.7
7.6
39
146
R01AD09
ATC
mometasone; nasal
1.4
7.6
463
3691
Z00.0
ICD-10 Finland
General medical examination
1.6
7.6
208
1411
A01
ICPC
Pain general/multiple sites
1.8
7.6
112
644
A10BJ05
ATC
dulaglutide; parenteral
3.6
7.6
24
67
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
7.6
110
630
A10BH02
ATC
vildagliptin; oral
3.2
7.6
29
92
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
3.2
7.6
29
92
C01BD01
ATC
amiodarone; systemic
3.3
7.6
28
87
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
3.3
7.6
28
87
R07.2
ICD-10 Finland
Precordial pain
3.3
7.5
27
82
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
2.8
7.5
37
136
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.8
7.5
37
136
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.3
7.5
57
258
F34.1
ICD-10 Finland
Dysthymia
2.6
7.5
42
165
H36.01
ICD-10 Finland
Diabetic maculopathy
4.3
7.5
19
45
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
4.3
7.5
19
45
SFA30
NOMESCO Finland
Three-surface restoration
1.4
7.5
401
3123
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.5
740
6420
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
7.4
246
1741
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.2
7.4
29
93
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
4.4
7.4
18
41
SPAT1304
SPAT
Counselling and guidance related to ageing
1.9
7.4
97
537
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
7.4
73
366
A10BH01
ATC
sitagliptin; oral
1.9
7.4
102
574
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.2
7.4
28
88
E06.9
ICD-10 Finland
Thyroiditis, unspecified
80.6
7.4
8
*
P01
ICPC
Feeling anxious/nervous/tense
1.8
7.4
118
695
A08
ICPC
Swelling
2.1
7.4
70
346
X58
ICD-10 Finland
Exposure to other specified factors
1.7
7.4
138
851
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.9
7.4
90
488
H66.9
ICD-10 Finland
Otitis media, unspecified
2.1
7.3
71
354
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.4
7.3
47
197
SFA10
NOMESCO Finland
One-surface restoration
1.4
7.3
550
4541
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
10.9
7.3
13
12
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.1
7.3
70
348
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
7.3
7
*
2506
FHL
Thyroidectomy
+∞
7.3
7
*
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
7.3
194
1308
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.0
7.3
80
418
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
7.3
79
411
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.0
7.3
75
383
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.3
7.3
51
223
RF120, ,
NOMESCO Finland
5.8
7.2
19
33
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.2
7.2
58
269
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
7.2
78
406
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.9
7.2
96
536
D02AE01
ATC
carbamide; topical
2.0
7.2
75
385
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.8
7.2
100
566
C01DA14
ATC
isosorbide mononitrate; oral
1.6
7.2
183
1222
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
30.2
7.2
9
*
RS142, ,
NOMESCO Finland
30.2
7.2
9
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.1
7.2
68
337
RJ210, ,
NOMESCO Finland
20.2
7.1
10
5
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
20.2
7.1
10
5
K59.09
ICD-10 Finland
Constipation, unspecified
2.0
7.1
76
393
B01AC04
ATC
clopidogrel; oral
1.6
7.1
170
1118
N02BF01
ATC
gabapentin; oral
1.9
7.1
92
509
M54.6
ICD-10 Finland
Pain in thoracic spine
2.0
7.1
81
430
SPAT1284
SPAT
Extensive health certificate
2.9
7.0
31
107
-50
ICPC
Medication/prescr/renewal
2.4
7.0
47
201
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.7
7.0
144
910
160
Kela drug reimbursment
exenatide
3.2
7.0
27
86
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
3.3
7.0
26
81
SGA01
NOMESCO Finland
Emergency treatment
1.6
7.0
151
968
WZC30
NOMESCO Finland
Teaching
1.6
7.0
150
960
K10.3
ICD-10 Finland
Alveolitis of jaws
2.3
7.0
50
221
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.5
6.9
258
1869
R05
ICD-10 Finland
Cough
1.5
6.9
221
1550
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.9
96
542
H02AA02
ATC
fludrocortisone; oral
5.5
6.9
19
35
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
5.9
6.9
18
31
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.9
679
5843
F10.20
ICD-10 Finland
Alcohol dependence currently independent
4.0
6.9
19
48
L16
ICPC
Ankle symptom/complaint
1.7
6.9
130
803
M01AX17
ATC
nimesulide; oral
1.5
6.9
259
1881
R13
ICD-10 Finland
Dysphagia
2.0
6.9
72
370
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
6.9
197
1350
K04.4
ICD-10 Finland
Acute apical periodontitis of pulpal origin
1.9
6.9
92
514
P72
ICPC
Schizophrenia
3.5
6.9
23
67
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.8
6.9
94
529
R07.3
ICD-10 Finland
Other chest pain
1.8
6.9
114
680
ACC51
NOMESCO Finland
Release of median nerve
1.9
6.9
84
456
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.6
6.8
37
143
SPAT1234
SPAT
Support of social functional capacity
2.0
6.8
73
378
CKC12
NOMESCO Finland
Photocoagulation of retina
2.5
6.8
42
173
I50.0
ICD-10 Finland
Congestive heart failure
1.8
6.8
93
523
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
11.0
6.8
12
11
R06AE07
ATC
cetirizine; oral
1.4
6.8
461
3729
B37.0
ICD-10 Finland
Candidal stomatitis
4.3
6.8
17
40
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.3
6.7
25
78
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
3.4
6.7
23
68
N04AA02
ATC
biperiden; systemic
3.3
6.7
24
73
A03FA02
ATC
cisapride; oral, rectal
1.8
6.7
94
533
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
6.7
201
1391
J01MA14
ATC
moxifloxacin; systemic
1.8
6.7
96
548
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
6.7
54
251
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
2.7
6.7
35
133
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.3
6.7
47
206
RK112, ,
NOMESCO Finland
22.7
6.7
9
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
22.7
6.7
9
*
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.7
298
2236
Z3231
NOMESCO Finland
Registered nurse
1.5
6.7
289
2156
XG466
NOMESCO Finland
Sleep oxymetry
2.9
6.7
30
105
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
6.5
6.6
16
25
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.8
6.6
31
111
C10AB05
ATC
fenofibrate; oral
3.6
6.6
21
59
R52.2
ICD-10 Finland
Other chronic pain
2.3
6.6
46
201
C03AA03
ATC
hydrochlorothiazide; oral
1.7
6.6
112
673
SPAT1359
SPAT
Use of symptom diary
2.9
6.6
30
106
XKD00
NOMESCO Finland
Uroflowmetry
1.8
6.6
102
597
A03
ICPC
Fever
1.6
6.5
166
1106
A10BD07
ATC
metformin and sitagliptin; systemic
2.4
6.5
43
183
ZYC01
NOMESCO Finland
Remote contact by phone
2.1
6.5
60
294
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.8
6.5
92
523
M47.9
ICD-10 Finland
Spondylosis, unspecified
2.5
6.5
38
153
R06.5
ICD-10 Finland
Mouth breathing
2.0
6.5
70
364
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
6.2
6.5
16
26
C09CA06
ATC
candesartan; oral
1.5
6.5
239
1727
M03BX02
ATC
tizanidine; oral
1.4
6.5
617
5259
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.7
6.5
33
124
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
70.2
6.4
7
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
6.4
250
1825
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.1
6.4
56
269
M48.0
ICD-10 Finland
Spinal stenosis
1.6
6.4
139
891
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.4
94
541
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.4
209
1474
L01
ICPC
Neck symptom/complaint
1.6
6.4
162
1080
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
6.3
63
318
205
Kela drug reimbursment
Chronic hypertension
1.4
6.3
293
2210
H93.1
ICD-10 Finland
Tinnitus
2.0
6.3
69
360
OAB50, ,
SPAT
2.1
6.3
58
284
K07
ICPC
Swollen ankles/oedema
2.1
6.3
59
291
R00.1
ICD-10 Finland
Bradycardia, unspecified
2.4
6.3
43
186
R03AK08
ATC
formoterol and beclometasone; inhalant
2.3
6.3
48
218
P73
ICPC
Affective psychosis
11.1
6.3
11
10
A10BG03
ATC
pioglitazone; oral
2.9
6.3
29
103
L29.8
ICD-10 Finland
Other pruritus
3.9
6.3
18
47
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
6.3
392
3117
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
6.3
6
*
RT422, ,
NOMESCO Finland
+∞
6.3
6
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
6.3
6
*
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
6.3
6
*
E00.0
ICD-10 Finland
Congenital iodine-deficiency syndrome, neurological type
+∞
6.3
6
*
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
6.3
6
*
2440A
ICD-9 Finland
Acquired hypothyroidism, Postsurgical hypothyroidism
+∞
6.3
6
*
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.7
6.3
121
753
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.5
6.2
37
150
A11CC02
ATC
dihydrotachysterol; oral
26.8
6.2
8
*
SFA20
NOMESCO Finland
Two-surface restoration
1.4
6.2
569
4806
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
6.2
178
1219
WX290
NOMESCO Finland
Other blockage of nerve
1.4
6.2
436
3533
M19.9
ICD-10 Finland
Arthrosis, unspecified
2.2
6.2
50
233
P25
ICPC
Phase of life problem adult
2.3
6.2
43
188
N05AX12
ATC
aripiprazole; systemic
2.5
6.2
36
145
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.1
6.1
59
294
N18.8
ICD-10 Finland
Other chronic renal failure
2.8
6.1
30
110
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.9
6.1
73
393
ZXA05
NOMESCO Finland
Left side
1.4
6.1
267
1992
R60.9
ICD-10 Finland
Oedema, unspecified
2.0
6.1
60
302
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
12.6
6.1
10
8
K11.2
ICD-10 Finland
Sialoadenitis
2.5
6.1
36
146
R4120
NOMESCO Finland
Occupational therapy
1.9
6.1
71
380
F20.9
ICD-10 Finland
Schizophrenia, unspecified
3.1
6.1
24
78
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
8.6
6.1
12
14
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
6.1
131
839
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
6.0
394
3150
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.4
6.0
40
171
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
3.5
6.0
20
58
61520
ICD-8 Finland
Other diseases of ovary and Fallopian tube, Cysta (cystis) follicularis ovarii (retentio)
3.5
6.0
20
58
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
5.2
6.0
17
33
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
6.1
6.0
15
25
62660
ICD-8 Finland
Disorders of menstruation, Intermenstrual bleeding
2.3
6.0
42
184

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
194
268
8.50
136.96
3.2
1.4
4.29
4.47
pmol/l
1.15
174
224
1036
6948
5.84
86.58
9.9
2.5
16.19
14.49
pmol/l
65.07
965
6190
1056
8511
3.86
39.80
11.5
3.4
1.96
1.90
mu/l
0.53
984
7684
766
5287
2.34
39.69
6.3
4.2
7.09
6.67
mmol/l
4.37
735
4901
654
4241
2.25
39.22
17.9
15.5
1.24
1.26
inr
0.24
190
1175
694
4634
2.25
38.41
8.5
5.7
1.22
1.22
mmol/l
0.27
583
3913
442
2459
2.29
38.33
2.4
2.3
3.24
3.07
mg/l
0.51
391
2089
433
2450
2.23
35.45
4.9
3.9
—
—
—
0
0
464
2741
2.16
33.69
2.3
2.1
148.12
200.03
u/l
1.47
440
2567
546
3464
2.09
32.56
5.7
3.8
38.23
50.65
ng/l
0.50
411
2419
683
4756
2.07
31.08
6.6
5.5
11.15
11.14
umol/l
0.00
651
4471
460
2796
2.07
30.19
3.6
2.2
58.76
61.11
u/l
0.14
442
2558
615
4161
2.02
29.85
7.7
5.2
1.22
1.22
mmol/l
0.58
564
3739
636
4360
2.02
29.69
7.4
5.4
56.86
57.61
%
0.82
595
4055
595
3987
2.02
29.59
2.8
2.3
78.67
77.72
nmol/l
0.32
536
3553
605
4100
2.00
28.90
3.4
2.7
107.24
107.32
ug/l
0.00
564
3770
149
560
2.91
28.88
3.8
4.0
5.16
5.16
kpa
0.04
144
535
579
3865
2.00
28.87
2.3
2.0
98.72
94.52
pmol/l
1.04
309
1917
263
1306
2.31
28.61
2.4
2.2
2.37
2.34
g/l
0.30
237
1200
147
552
2.91
28.53
3.7
4.0
7.42
7.41
ph
0.56
15
64
639
4427
1.99
28.50
7.8
5.6
28.07
27.70
%
0.35
596
4124
279
1431
2.25
28.04
2.6
2.2
11.83
12.49
umol/l
0.79
262
1322
624
4314
1.97
27.71
8.0
5.8
8.34
8.41
%
0.21
581
4005
333
1849
2.13
27.31
2.1
1.7
1217.10
1175.70
nmol/l
0.26
245
1362
836
6423
2.10
27.24
7.7
4.8
738.71
2433.56
e6/l
1.15
52
85
354
2014
2.09
27.21
1.9
1.7
81017373.85
35969054.04
pmol/l
0.33
295
1657
619
4297
1.95
26.84
7.7
5.5
2.87
2.74
%
0.70
574
3978
442
2738
2.00
26.75
4.0
3.0
1632.17
1494.04
ng/l
0.28
388
2323
425
2602
2.00
26.56
5.2
3.9
—
—
—
0
0
645
4562
1.94
26.20
7.2
5.4
0.04
0.04
e9/l
0.55
566
3927
658
4688
1.94
26.12
7.1
5.4
1.90
1.87
e9/l
0.29
594
4139
50
93
5.57
25.89
1.8
1.2
3.73
1.29
iu/l
2.86
22
14
642
4548
1.93
25.80
7.2
5.4
0.61
0.57
e9/l
1.85
568
3912
518
3423
1.93
25.65
4.1
3.3
—
—
—
0
0
598
4166
1.90
25.00
7.7
5.6
0.64
0.66
%
0.38
555
3850
603
4237
1.89
24.30
7.7
5.9
—
—
—
0
0
655
4730
1.89
24.19
7.4
5.6
0.19
0.18
e9/l
0.88
586
4123
191
887
2.38
23.90
6.1
3.9
—
—
—
0
0
238
1218
2.20
23.64
2.5
2.3
20.04
21.81
%
1.33
207
1042
443
2854
1.90
23.06
3.3
3.0
33.42
32.00
u/l
0.26
420
2712
576
4035
1.85
22.98
5.4
4.2
34.27
35.27
g/l
3.96
542
3729
830
6560
1.95
22.28
6.6
4.6
—
—
—
0
0
429
2777
1.87
21.69
4.4
3.2
38.34
83.68
e6/l
0.92
350
2099
169
778
2.37
21.45
2.1
1.7
361.79
375.28
nmol/l
0.36
157
699
874
7091
1.96
20.88
9.8
6.8
83.65
79.26
u/l
1.39
841
6611
215
1115
2.14
20.41
6.9
4.8
1.08
1.06
mmol/l
0.38
205
1028
485
3310
1.80
20.30
5.2
3.7
85.78
112.04
e6/l
0.43
372
2261
250
1378
2.04
20.15
3.2
3.0
0.81
0.82
mmol/l
0.66
236
1286
406
2641
1.83
19.81
4.2
3.0
6.28
6.82
mmol/l
2.09
340
2199
321
1943
1.90
19.65
3.8
2.5
7.33
6.93
e6/l
0.21
298
1721
337
2084
1.87
19.24
1.4
1.3
1.74
1.56
u/ml
0.12
93
517
382
2467
1.82
18.91
4.3
3.0
490.06
347.41
mg/l
0.22
268
1519
397
2606
1.80
18.54
4.9
3.6
12.84
9.05
mg/mmol
0.78
278
1584
841
6851
1.84
18.37
6.1
4.0
14.23
13.13
mm/h
1.32
790
6289
688
5330
1.72
17.42
11.2
8.3
4.23
4.09
e9/l
0.86
622
4611
210
1149
2.01
17.04
1.3
1.3
477.33
602.61
titre
0.46
45
245
141
662
2.29
16.95
5.7
3.2
—
—
—
0
0
195
1042
2.05
16.88
2.1
1.7
—
—
—
0
0
581
4335
1.69
16.61
3.0
2.5
—
—
—
0
0
69
230
3.13
16.39
4.5
3.5
21.67
27.08
mg/l
0.67
54
143
428
2955
1.71
16.27
2.6
2.3
—
—
—
0
0
336
2168
1.78
16.24
2.9
2.5
5622.31
7604.07
umol/l
0.31
285
1877
196
1065
2.01
16.15
2.6
2.5
1.94
1.80
%
0.91
171
921
286
1769
1.82
15.88
1.5
1.5
2.13
2.33
g/l
1.31
153
1038
371
2476
1.73
15.86
5.4
3.6
—
—
—
0
0
97
406
2.52
15.03
4.1
4.2
—
—
—
0
0
714
5715
1.65
14.81
4.0
3.0
56.76
45.08
u/l
2.08
669
5267
339
2246
1.72
14.68
1.7
1.5
20.04
20.76
nmol/l
0.37
285
1872
298
1904
1.76
14.68
3.7
3.0
525.81
523.93
mosm/kgh2o
0.05
262
1616
86
348
2.59
14.29
2.4
2.0
1.19
2.50
ug/l
0.79
70
299
95
406
2.46
14.08
1.3
1.1
250.90
65.45
iu/ml
3.79
51
124
210
1228
1.87
13.78
1.2
1.2
—
—
—
0
0
946
8246
1.82
13.52
8.6
5.5
43.09
39.64
mmol/mol
13.56
864
7576
121
591
2.17
13.14
3.7
2.7
4.67
5.83
e9/l
0.67
93
462
137
704
2.07
13.04
7.7
6.2
11.22
9.47
mmol/l
1.84
131
666
452
3305
1.60
12.99
3.1
3.3
2.34
2.36
mmol/l
3.27
382
2863
307
2042
1.69
12.84
6.1
4.3
1.02
1.01
kg/l
0.23
70
305
34
83
4.19
12.82
1.4
1.3
—
—
—
0
0
592
4623
1.58
12.77
5.3
3.9
0.00
0.00
estimate
0.75
111
911
83
351
2.47
12.59
4.3
4.5
24.78
24.86
mmol/l
0.10
77
330
104
486
2.25
12.58
1.3
1.3
—
—
—
0
0
1028
9264
2.01
12.39
24.4
13.8
20.56
23.86
mg/l
3.29
914
7308
173
990
1.88
12.05
2.5
2.7
7.18
7.40
umol/l
0.06
150
841
594
4693
1.55
11.81
5.5
3.9
0.00
0.01
estimate
0.80
106
820
1040
9448
2.03
11.67
27.7
15.8
139.17
139.56
mmol/l
4.27
1024
9173
135
720
1.99
11.57
4.2
3.5
115.14
85.17
ng/l
1.40
109
616
203
1236
1.78
11.53
2.3
1.9
—
—
—
0
0
1040
9467
2.01
11.31
28.0
15.9
3.97
3.96
mmol/l
0.81
1022
9164
347
2452
1.59
11.15
5.2
4.2
0.00
0.01
estimate
1.08
105
817
54
197
2.83
10.99
2.2
2.3
127.61
126.55
g/l
0.09
39
144
184
1103
1.80
10.99
5.4
4.2
33.67
33.46
%
0.09
136
717
167
982
1.82
10.61
1.5
1.4
—
—
—
0
0
241
1573
1.67
10.59
1.5
1.3
44.21
36.12
iu/ml
0.35
78
518
582
4647
1.51
10.56
7.4
5.4
0.00
0.00
estimate
0.50
105
830
73
316
2.40
10.54
2.5
3.3
0.27
0.26
g/l
0.03
30
118
136
754
1.91
10.39
2.5
2.6
64.13
66.45
g/l
2.72
118
684
88
418
2.20
10.24
1.9
1.7
1.56
1.52
g/l
0.14
65
361
117
621
1.98
10.15
2.5
2.8
10.53
10.38
g/l
0.14
105
566
48
178
2.77
9.51
2.5
2.4
207.43
71.66
ug/min
1.18
31
101
228
1512
1.63
9.31
1.4
1.2
12.55
12.35
u/ml
0.01
84
565
41
142
2.96
9.20
1.7
1.4
—
—
—
0
0
135
787
1.81
8.78
2.7
2.5
73.75
70.55
e9/l
0.39
108
589
143
854
1.77
8.58
2.8
2.2
0.20
0.21
g/l
0.42
129
810
152
929
1.73
8.41
1.3
1.3
—
—
—
0
0
290
2078
1.53
8.40
1.7
1.7
0.99
1.18
mg/l
1.24
226
1574
126
731
1.81
8.32
5.2
3.9
0.91
0.93
%
0.04
58
246
33
107
3.15
8.30
22.9
4.7
7.91
7.35
mmol/l
0.27
28
85
207
1383
1.61
8.12
2.1
1.9
30.08
29.57
s
0.65
201
1331
12
7
17.31
8.08
4.3
1.7
—
—
—
0
0
120
698
1.80
7.86
5.2
3.9
0.06
0.11
%
0.71
52
212
62
286
2.23
7.79
6.0
5.2
1.49
1.30
mmol/l
0.71
56
253
26
76
3.48
7.70
3.3
2.3
—
—
—
0
0
84
441
1.98
7.54
9.7
7.7
—
—
—
0
0
24
68
3.58
7.44
3.8
2.8
24.81
13.05
mg/l
0.31
19
48
43
173
2.54
7.32
3.9
3.6
—
—
—
0
0
55
249
2.27
7.24
1.4
1.4
261.31
306.95
ug/g
1.04
35
135
962
8811
1.55
7.09
5.9
4.3
6.20
5.88
mmol/l
6.14
885
7923
31
107
2.95
7.05
1.4
1.2
—
—
—
0
0
40
159
2.57
6.99
2.8
2.7
—
—
—
0
0
78
414
1.95
6.80
1.9
1.8
—
—
—
0
0
122
745
1.71
6.76
1.3
1.2
—
—
—
0
0
135
851
1.66
6.64
7.4
6.3
94.05
95.49
%
1.36
128
818
110
657
1.75
6.59
5.5
4.0
0.21
0.12
%
0.23
43
172
246
1783
1.48
6.57
5.3
3.5
381.01
296.56
ng/l
0.12
191
1374
24
76
3.20
6.31
1.1
1.1
—
—
—
0
0
350
2727
1.41
6.30
5.5
3.5
7.40
7.40
ph
0.69
80
503
203
1428
1.51
6.25
3.4
2.9
3.90
3.57
e6/l
0.16
121
756
24
77
3.16
6.19
1.6
2.1
1.43
1.11
e9/l
0.49
19
68
10
8
12.60
6.08
2.4
1.6
11.01
14.75
umol/l
—
10
8
45
203
2.27
6.01
1.3
1.6
428.37
501.06
mg/l
0.92
40
190
135
876
1.61
5.92
3.9
3.7
1.89
1.89
mmol/l
0.00
113
715
1035
9726
1.63
5.89
14.6
9.8
25.12
23.66
u/l
0.89
1007
9355
453
3719
1.36
5.83
4.3
3.7
5.71
5.86
ph
0.27
14
238
108
669
1.68
5.69
4.4
3.8
0.64
0.72
%
0.19
49
208
39
170
2.34
5.65
4.6
3.8
2.74
2.77
mmol/l
0.02
32
114
953
8822
1.46
5.57
5.6
4.1
4.56
4.70
mmol/l
4.10
877
8082
15
29
5.23
5.40
3.4
2.7
—
—
—
0
0
916
8432
1.42
5.39
5.1
3.7
1.36
1.23
mmol/l
6.00
829
7606
118
759
1.62
5.37
2.7
2.4
5.06
5.94
ug/l
0.40
92
643
157
1081
1.52
5.32
2.1
2.4
172.27
109.81
ug/g
0.77
125
840
145
984
1.54
5.25
7.5
6.0
1.23
1.17
mmol/l
0.06
114
772
104
652
1.65
5.24
2.3
2.3
—
—
—
0
0
85
505
1.74
5.22
1.6
1.8
1.21
1.65
g/l
1.42
76
460
49
243
2.06
5.21
2.8
3.7
8.71
8.55
kpa
0.16
49
236
145
990
1.53
5.11
7.5
6.0
4.98
5.08
kpa
0.56
138
941
145
991
1.53
5.08
7.5
6.0
11.49
12.21
kpa
0.89
137
945
18
55
3.31
5.04
1.7
2.2
0.23
0.20
e9/l
0.22
13
47
39
180
2.21
4.98
1.8
1.9
193.68
1782.98
e6/l
0.57
34
143
39
180
2.21
4.98
1.6
1.8
3.15
17.48
e6/l
1.49
34
135
943
8760
1.42
4.97
5.6
4.1
1.46
1.53
mmol/l
6.01
859
7980
133
897
1.55
4.95
1.6
1.5
—
—
—
0
0
1075
10264
1.70
4.93
35.5
20.3
6.98
6.71
e9/l
3.19
1055
9928
31
130
2.42
4.92
3.1
3.1
1.08
1.71
%
0.61
26
116
320
2543
1.36
4.92
4.1
3.1
0.45
0.48
e6/l
0.08
252
1922
122
809
1.57
4.90
3.4
2.9
213.75
220.76
ng/l
0.07
112
739
1074
10255
1.69
4.89
35.3
20.3
38.41
39.06
%
2.14
1009
9541
22
78
2.86
4.83
2.4
2.7
1.70
1.38
g/24h
0.21
13
42
29
119
2.47
4.82
1.6
1.3
23.95
23.23
u/l
0.05
23
99
1074
10261
1.68
4.79
35.5
20.3
257.16
255.26
e9/l
0.42
1058
9966
11
17
6.52
4.78
1.4
1.4
—
—
—
0
0
1074
10263
1.68
4.76
35.3
20.2
29.96
30.18
pg
3.19
1066
10087
966
9029
1.43
4.76
6.0
4.6
2.63
2.75
mmol/l
3.71
886
8231
54
287
1.92
4.76
4.4
5.3
—
—
—
0
0
53
280
1.94
4.76
2.2
2.6
—
—
—
0
0
1074
10264
1.68
4.75
35.5
20.3
4.36
4.39
e12/l
1.58
1054
9933
66
375
1.81
4.74
1.0
1.1
—
1.05
—
0
6
1074
10267
1.67
4.70
35.7
20.4
129.71
131.76
g/l
5.14
1064
10090
286
2247
1.36
4.70
2.6
2.2
—
—
—
0
0
18
58
3.14
4.65
1.7
2.2
649.83
477.02
e6/l
0.48
12
48
1073
10261
1.66
4.61
35.4
20.2
90.66
90.95
fl
1.15
1065
10087
74
439
1.73
4.60
1.3
1.4
31.85
29.67
iu/l
0.21
67
377
24
92
2.64
4.58
4.5
6.2
12.29
12.00
mg/l
0.15
17
82
24
93
2.61
4.49
2.5
2.4
0.56
2.07
u/field
—
9
30
27
111
2.47
4.49
2.8
2.8
—
—
—
0
0
1016
9609
1.48
4.49
23.8
13.0
—
—
—
0
0
16
49
3.30
4.48
1.8
1.8
2.00
2.35
u/field
—
10
35
309
2477
1.34
4.42
4.0
3.1
—
—
—
0
0
21
77
2.76
4.36
1.8
2.0
—
—
—
0
0
66
385
1.76
4.36
5.7
4.2
1.76
1.53
%
0.96
60
364
23
89
2.62
4.32
4.0
3.8
—
—
—
0
0
88
557
1.63
4.31
5.1
4.4
—
—
—
0
0
59
337
1.79
4.19
2.3
2.1
403.43
4075.71
u/l
2.26
22
145
12
25
4.84
4.19
1.7
2.0
—
—
—
0
0
13
30
4.37
4.13
3.5
2.9
48600.00
39133.33
ug/l
0.39
13
30
29
129
2.28
4.08
3.1
2.9
—
—
—
0
0
24
100
2.43
3.91
1.3
1.1
—
—
nmol/l
—
0
0
13
32
4.10
3.91
2.0
4.9
313.71
168.83
umol/l
—
7
23
52
293
1.81
3.88
4.8
3.3
239.13
92.80
mg/l
0.53
39
231
52
294
1.81
3.84
4.8
3.3
27.68
46.25
mg/l
0.88
39
231
29
133
2.21
3.82
1.1
1.5
—
—
—
0
0
434
3709
1.27
3.74
2.3
2.1
—
—
—
0
0
138
995
1.44
3.73
3.6
4.0
24.14
22.16
ug/l
0.03
105
819
27
122
2.24
3.69
1.4
1.1
0.64
0.61
nmol/l
0.22
27
112
15
51
2.97
3.58
1.4
1.1
241.33
224.31
mg/l
0.15
15
42
282
2292
1.30
3.58
1.7
1.6
1.44
1.32
mmol/l
1.30
253
1936
33
164
2.04
3.57
1.8
1.9
—
—
—
0
0
63
385
1.67
3.57
5.8
4.2
0.91
0.89
%
0.16
57
362
7
9
7.82
3.56
3.6
2.4
—
—
—
0
0
107
742
1.49
3.54
4.9
3.5
1.22
1.23
mmol/l
0.86
101
642
11
27
4.10
3.40
1.2
1.3
—
—
—
0
0
79
518
1.56
3.39
2.8
2.4
—
—
—
0
0
9
18
5.03
3.37
1.2
1.9
—
—
—
0
0
108
762
1.46
3.29
3.0
3.2
4.79
4.46
kpa
1.04
102
736
460
4005
1.25
3.28
13.9
9.1
0.00
0.00
e9/l
1.26
383
3257
32
163
1.99
3.26
1.7
1.6
—
—
—
0
0
16
60
2.69
3.23
3.3
2.5
—
—
—
0
0
18
74
2.46
3.05
1.4
1.2
—
—
—
0
0
5
5
10.04
2.98
1.0
1.0
—
—
—
0
0
25
484
0.51
2.97
1.5
1.4
—
—
—
0
0
24
114
2.13
2.96
1.4
1.1
—
—
—
0
0
43
705
0.59
2.88
1.5
1.3
—
—
—
0
0
13
47
2.79
2.82
10.3
15.2
—
—
—
0
0
17
71
2.42
2.81
1.9
1.4
32.17
28.00
%
0.17
12
44
56
356
1.60
2.78
2.3
2.1
9.14
10.14
g/l
0.95
47
313
22
105
2.12
2.70
2.0
1.6
61.67
62.88
%
0.05
15
68
10
29
3.47
2.69
1.0
1.7
—
—
—
0
0
9
24
3.77
2.67
1.0
1.1
114.00
146.90
mmol/24h
—
9
24
164
1287
1.32
2.66
1.7
1.6
—
—
—
0
0
37
213
1.76
2.66
5.1
3.4
—
—
—
0
0
12
41
2.95
2.62
2.2
1.3
—
—
—
0
0
112
835
1.38
2.55
4.3
2.1
34.84
39.25
u/l
0.35
93
700
57
373
1.56
2.53
2.3
1.3
—
—
—
0
0
278
2349
1.24
2.50
7.7
6.3
—
—
—
0
0
15
63
2.40
2.47
1.3
2.2
37.81
39.16
%
0.11
15
63
87
625
1.42
2.46
1.6
1.4
—
—
—
0
0
37
219
1.71
2.44
1.8
1.7
14018.89
13277.94
e6/l
0.03
27
159
100
738
1.39
2.43
8.4
6.7
—
—
—
0
0
8
22
3.65
2.36
1.1
1.4
73.13
64.45
nmol/24h
—
8
22
10
33
3.05
2.36
1.1
1.2
89.80
79.95
mg/l
—
5
19
51
333
1.56
2.31
1.2
1.3
0.24
1.13
u/ml
—
5
28
40
247
1.64
2.27
1.3
1.3
—
—
—
0
0
6
13
4.63
2.27
1.2
1.5
93.17
81.92
ng/l
—
6
13
30
171
1.77
2.26
3.0
2.5
17.09
15.77
%
1.44
17
90
16
73
2.21
2.21
1.5
1.2
—
—
—
0
0
8
24
3.35
2.18
1.6
1.6
—
—
—
0
0
10
36
2.79
2.14
2.2
1.3
3.20
1.00
%
—
5
6
26
146
1.80
2.07
1.8
1.5
—
—
—
0
0
26
146
1.80
2.07
3.8
2.4
—
—
—
0
0
266
2279
1.22
2.07
4.5
3.6
90.01
91.36
%
0.32
255
2218
17
82
2.09
2.07
1.5
1.3
142786.67
127346.71
e6/l
0.04
12
51
25
139
1.82
2.06
2.2
2.6
—
—
—
0
0
8
26
3.09
2.01
1.0
1.0
1357.25
1725.35
miu/ml
—
8
26
14
63
2.24
2.01
1.2
1.2
—
—
—
0
0
64
453
1.44
2.00
3.5
4.0
24.08
23.93
mmol/l
0.11
64
443
73
531
1.40
1.97
3.8
4.0
—
—
—
0
0
11
46
2.40
1.85
2.1
1.6
—
—
—
0
0
13
59
2.22
1.84
1.2
1.1
—
—
—
0
0
39
254
1.55
1.83
3.4
2.6
—
—
—
0
0
16
80
2.01
1.80
2.4
2.2
—
—
—
0
0
18
95
1.91
1.76
1.1
1.1
—
—
—
0
0
17
88
1.95
1.75
1.6
1.3
—
—
—
0
0
27
164
1.66
1.69
2.7
1.7
4.40
4.68
mmol/24h
0.13
22
144
17
90
1.90
1.65
1.4
1.3
42590.82
41192.04
e6/l
0.02
11
56
22
127
1.75
1.65
1.6
1.5
112.50
112.99
u/ml
—
8
31
74
558
1.35
1.64
1.2
1.4
—
—
—
0
0
10
41
2.45
1.64
6.8
4.3
—
—
—
0
0
19
105
1.82
1.63
1.8
2.4
—
—
—
0
0
668
6275
1.15
1.62
4.4
3.7
—
—
—
0
0
5
14
3.58
1.61
1.0
1.0
—
—
—
0
0
96
754
1.30
1.61
1.5
1.4
—
—
—
0
0
8
32
2.51
1.60
1.0
1.2
—
—
—
0
0
10
43
2.34
1.59
1.2
1.3
—
—
—
0
0
40
272
1.49
1.58
1.1
1.3
178.81
244.55
miu/ml
0.62
24
128
28
177
1.60
1.52
4.9
2.0
0.96
0.79
nmol/l
0.35
21
145
179
1522
1.21
1.52
3.2
2.7
0.80
1.69
e6/l
2.48
95
844
6
21
2.87
1.50
2.8
1.3
—
—
—
0
0
21
124
1.71
1.48
1.0
1.1
15.60
4629.79
iu/ml
—
5
28
94
748
1.28
1.45
3.1
3.6
—
—
—
0
0
32
212
1.52
1.44
1.5
1.5
—
—
—
0
0
6
22
2.74
1.43
1.3
1.2
—
—
—
0
0
35
237
1.49
1.43
3.9
3.2
1.01
0.85
nmol/l
1.22
27
186
40
279
1.45
1.42
2.1
2.0
9.98
11.04
nmol/l
0.25
33
248
42
301
1.41
1.31
2.7
2.1
37.08
37.34
g/l
0.11
33
260
6
24
2.51
1.30
1.2
1.1
—
—
—
0
0
176
1520
1.19
1.28
1.9
1.8
—
—
—
0
0
15
84
1.80
1.27
2.0
1.4
—
—
—
0
0
51
382
1.35
1.24
1.2
1.2
—
—
—
0
0
23
147
1.58
1.23
1.1
1.3
242.42
268.75
u/ml
0.16
12
78
14
78
1.80
1.21
1.2
1.2
—
—
—
0
0
17
101
1.69
1.20
3.5
1.5
283.45
276.83
mosm/kgh2o
0.55
11
69
13
71
1.84
1.19
1.5
1.2
—
—
—
0
0
28
189
1.49
1.19
1.5
1.4
60.45
61.62
mmol/l
0.05
20
149
10
50
2.01
1.16
1.0
1.0
693.20
608.96
ng/l
—
5
26
18
110
1.65
1.15
4.3
1.7
—
—
—
0
0
0
35
0.00
1.15
0.0
1.5
—
—
—
0
0
5
21
2.39
1.09
1.0
1.5
—
—
—
0
0
5
21
2.39
1.09
1.4
1.3
—
—
—
0
0
15
89
1.69
1.08
1.5
1.6
—
—
—
0
0
13
74
1.77
1.07
1.3
1.1
2.30
1.83
u/ml
—
8
36
26
178
1.47
1.06
2.5
3.1
4.45
4.28
e9/l
0.14
26
178
7
33
2.13
1.05
1.3
1.3
—
—
—
0
0
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
7
34
2.07
1.03
3.0
1.7
—
—
—
0
0
26
180
1.45
1.01
3.9
3.2
—
—
—
0
0
15
91
1.66
1.00
4.1
1.7
—
—
—
0
0
12
200
0.60
0.99
1.4
1.5
—
—
—
0
0
7
36
1.95
0.97
1.0
1.0
—
—
—
0
0
19
124
1.54
0.97
1.2
1.0
—
—
—
0
0
9
50
1.81
0.96
1.6
1.9
—
—
—
0
0
28
199
1.42
0.96
3.1
1.5
—
—
—
0
0
42
322
1.32
0.92
1.1
1.1
—
—
—
0
0
320
2953
1.12
0.92
3.4
2.7
—
—
—
0
0
12
195
0.61
0.91
1.3
1.4
—
—
—
0
0
12
194
0.61
0.89
1.2
1.4
—
—
—
0
0
826
8007
1.11
0.88
28.5
16.5
15.68
14.91
%
2.87
821
7856
25
178
1.41
0.86
3.4
1.8
—
—
—
0
0
26
187
1.40
0.85
2.5
3.3
56.88
57.99
%
0.18
26
187
11
65
1.70
0.82
1.1
1.0
—
—
—
0
0
19
130
1.47
0.81
1.2
1.2
—
—
—
0
0
127
1115
1.16
0.80
1.3
1.3
—
—
—
0
0
206
1870
1.12
0.79
3.1
2.8
2.45
2.46
mmol/l
0.44
168
1630
6
33
1.82
0.79
1.3
1.2
12.85
29.47
nmol/l
—
6
26
41
323
1.28
0.77
3.2
4.5
—
—
—
0
0
27
200
1.36
0.76
1.2
1.1
—
—
—
0
0
10
59
1.70
0.76
1.3
1.2
—
—
—
0
0
92
792
1.18
0.75
1.3
1.4
—
—
—
0
0
141
1255
1.14
0.75
5.2
5.1
2.50
3.48
ug/l
0.67
123
1093
88
756
1.18
0.74
5.9
4.1
—
—
—
0
0
7
38
1.85
0.73
1.4
1.2
—
—
—
0
0
18
125
1.45
0.73
1.1
1.0
—
—
—
0
0
5
25
2.00
0.72
1.0
1.1
—
—
—
0
0
11
68
1.62
0.72
1.2
1.1
—
—
—
0
0
5
26
1.93
0.70
1.2
1.1
—
—
—
0
0
5
26
1.93
0.70
3.8
2.3
—
—
—
0
0
10
61
1.64
0.68
2.0
2.1
—
—
—
0
0
7
43
1.63
0.67
1.1
1.4
—
—
—
0
0
7
43
1.63
0.67
1.3
1.2
—
—
—
0
0
5
29
1.73
0.64
28.0
33.4
73.40
113.70
ug/l
—
5
23
19
138
1.38
0.62
1.2
1.1
—
—
—
0
0
73
629
1.17
0.62
1.4
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
4.6
—
87.18
—
0
13
8
52
1.54
0.59
4.9
1.3
163.50
75.40
umol/l
—
8
52
14
97
1.45
0.59
1.2
1.1
—
—
—
0
0
18
132
1.37
0.57
1.4
1.2
3.33
2.27
u/ml
—
9
55
29
230
1.27
0.55
3.1
1.5
—
—
—
0
0
6
38
1.58
0.54
1.3
1.4
138.00
150.34
nmol/l
—
6
38
31
249
1.25
0.54
3.1
1.5
—
—
—
0
0
31
250
1.25
0.53
3.1
1.5
—
—
—
0
0
18
135
1.34
0.51
1.8
2.1
—
—
—
0
0
31
252
1.24
0.50
3.1
1.5
—
—
—
0
0
7
108
0.65
0.48
2.3
3.3
—
—
—
0
0
14
102
1.38
0.47
1.0
1.3
—
35.30
—
0
6
7
51
1.37
0.44
1.3
1.1
—
—
—
0
0
18
139
1.30
0.43
1.4
1.3
—
—
—
0
0
30
248
1.22
0.43
1.8
1.4
—
—
—
0
0
19
149
1.28
0.42
1.1
1.1
2.38
7.71
u/ml
1.65
13
86
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
4.8
3.2
537.80
659.26
u/ml
—
5
34
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
5
36
1.39
0.38
2.0
1.7
25.00
30.17
umol/l
—
5
36
19
152
1.25
0.37
1.2
1.5
—
—
—
0
0
12
90
1.34
0.36
1.4
1.2
—
—
—
0
0
11
145
0.76
0.34
2.4
1.8
—
—
—
0
0
6
46
1.31
0.33
1.2
1.2
—
2.18
—
0
16
10
74
1.35
0.32
1.2
1.3
—
—
—
0
0
34
300
1.14
0.26
1.3
1.2
—
—
—
0
0
103
965
1.07
0.26
1.7
1.8
—
—
—
0
0
8
67
1.20
0.26
1.0
1.3
—
—
—
0
0
11
86
1.28
0.26
1.5
1.3
—
—
—
0
0
9
72
1.25
0.25
1.2
1.1
—
—
—
0
0
38
343
1.11
0.22
1.4
1.7
—
—
—
0
0
20
172
1.17
0.22
1.2
1.1
1.43
3.05
u/ml
0.50
13
102
0
11
0.00
0.21
0.0
1.7
—
7.46
—
0
5
0
11
0.00
0.21
0.0
1.4
—
49.91
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
22
192
1.15
0.20
1.3
1.2
—
—
—
0
0
17
145
1.17
0.20
1.1
1.1
0.27
2.24
u/ml
—
10
76
0
14
0.00
0.20
0.0
2.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.5
—
—
—
0
0
13
155
0.84
0.20
1.3
1.3
—
—
—
0
0
29
262
1.11
0.17
1.3
1.2
—
—
—
0
0
32
291
1.10
0.17
3.5
3.5
—
—
—
0
0
10
82
1.22
0.17
2.4
2.7
—
—
—
0
0
5
66
0.76
0.17
4.2
3.9
12.64
10.53
%
—
5
66
7
86
0.81
0.14
1.3
1.1
—
—
—
0
0
81
847
0.95
0.13
1.6
1.6
—
—
—
0
0
14
123
1.14
0.12
1.4
1.0
3.03
2.36
u/ml
—
6
50
28
303
0.92
0.12
11.6
9.0
—
—
—
0
0
31
289
1.07
0.11
1.3
1.3
—
—
—
0
0
5
46
1.09
0.09
2.0
2.0
—
—
—
0
0
5
61
0.82
0.08
1.4
1.2
—
—
—
0
0
7
64
1.09
0.08
1.0
1.1
—
9.31
—
0
14
8
78
1.03
0.07
1.5
1.3
6.38
7.04
mmol/l
—
8
72
226
2229
1.02
0.07
4.4
3.9
—
—
—
0
0
38
364
1.05
0.06
2.9
2.8
194.62
998.47
u/ml
0.95
32
316
250
2475
1.01
0.05
1.5
1.4
—
—
—
0
0
14
130
1.08
0.04
1.2
1.1
—
—
—
0
0
14
130
1.08
0.04
1.2
1.1
—
—
—
0
0
13
139
0.93
0.03
1.2
1.1
3.07
1.07
u/ml
—
8
78
73
718
1.02
0.03
2.8
3.0
0.58
0.83
ug/l
2.75
53
471
87
859
1.01
0.02
1.4
1.4
—
—
—
0
0
11
103
1.07
0.02
1.1
1.1
—
—
—
0
0
30
306
0.98
0.00
1.0
1.1
—
—
—
0
0
15
148
1.01
0.00
2.9
2.8
58.40
60.93
%
0.20
15
148
13
129
1.01
0.00
1.2
1.2
—
—
—
0
0
11
115
0.96
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
9
98
0.92
-0.00
1.7
2.1
13.03
13.17
%
—
9
98
5
57
0.88
-0.00
2.8
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_CONGEIOD and mortality.

Females

Parameter HR [95% CI] p-value
E4_CONGEIOD 1.653 [1.47, 1.86] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 2652 out of 8009 females with E4_CONGEIOD died.

Males

Parameter HR [95% CI] p-value
E4_CONGEIOD 2.094 [1.67, 2.62] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 700 out of 1891 males with E4_CONGEIOD died.

Mortality risk

Mortality risk for people of age

years, who have E4_CONGEIOD.

N-year risk Females Males
1 0.098% 0.386%
5 0.745% 2.472%
10 1.882% 5.762%
15 3.749% 10.868%
20 6.505% 17.926%

Relationships between endpoints

↥

Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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