≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO Endpoint Browser PheWeb

E4_CONGEIOD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E00, E03.0, E03.1
  • Hospital discharge: ICD-9 — 243
  • Hospital discharge: ICD-8 — 243
  • Cause of death: ICD-10 — E00, E03.0, E03.1
  • Cause of death: ICD-9 — 243
  • Cause of death: ICD-8 — 243

2 out of 7 registries used, show all original rules.

1139

4. Check minimum number of events

None

1139

5. Include endpoints

None

1139

6. Filter based on genotype QC (FinnGen only)

1139

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11024 8810 2178
Only index persons 10110 8174 1936
Unadjusted period prevalence (%)
Whole population 0.21 0.25 0.06
Only index persons 0.26 0.30 0.07
Median age at first event (years)
Whole population 67.75 68.82 63.38
Only index persons 67.54 68.52 63.45

-FinnGen-

Key figures

All Female Male
Number of individuals 1139 913 226
Unadjusted period prevalence (%) 0.27 0.31 0.10
Median age at first event (years) 60.54 59.01 66.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1047
Matched controls
10470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
871.9
323.0
681
22
104
Kela drug reimbursment
Thyroid insufficiency
4014.9
323.0
431
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
323.0
848
*
H03AA01
ATC
levothyroxine sodium; systemic
2362.3
323.0
1007
110
E03
ICD-10 Finland
Other hypothyroidism
232.6
205.5
206
11
E03.89
ICD-10 Finland
Other specified hypothyroidism
2252.2
189.5
178
*
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
+∞
185.0
172
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
1102.8
104.1
100
*
T86
ICPC
Hypothyroidism/myxoedema
147.2
101.1
106
8
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
48.0
65.9
80
18
H03BB01
ATC
carbimazole; oral
108.7
65.7
71
7
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
53.6
51
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
185.8
51.4
53
*
M14.5*E03.9
ICD-10 Finland
Arthropathy in hypothyroidism (E00-E03+)
+∞
37.7
36
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
46.9
37.2
45
10
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
348.0
34.1
34
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
6.3
33.2
92
158
BAA60
NOMESCO Finland
Total thyroidectomy
337.3
33.1
33
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.1
30.8
128
343
A10AE04
ATC
insulin glargine; parenteral
3.6
28.5
137
416
C03CA01
ATC
furosemide; systemic
2.2
28.0
381
2160
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
4.9
27.9
95
209
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
6.0
27.7
79
141
J01MA12
ATC
levofloxacin; systemic
2.6
26.6
233
1053
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
25.9
285
1451
N05AH04
ATC
quetiapine; oral
2.7
25.9
200
842
SPAT1254
SPAT
Administration of medicine
2.6
25.5
222
999
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.9
25.5
73
131
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
25.3
226
1033
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
25.2
490
3186
A10AE05
ATC
insulin detemir; parenteral
4.2
24.9
98
249
T89
ICPC
Diabetes insulin dependent
5.8
24.6
71
129
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.2
24.0
54
69
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.4
23.9
123
393
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
127.9
23.7
25
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
23.1
311
1723
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
23.0
22
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
22.9
303
1664
A02BC02
ATC
pantoprazole; systemic
2.0
22.9
695
5265
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
6.6
22.6
59
94
N03AX16
ATC
pregabalin; oral
2.2
21.8
283
1533
SPAT1263
SPAT
Sampling
1.9
21.7
491
3314
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
21.7
404
2541
N02BE01
ATC
paracetamol; systemic, rectal
2.4
21.5
919
7875
N05CF01
ATC
zopiclone; oral
2.0
20.9
377
2332
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
20.8
326
1908
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.0
20.5
316
1835
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
20.4
623
4634
H04AA01
ATC
glucagon; nasal, parenteral
7.8
20.0
46
61
A10AA01
ATC
NA
6.4
19.9
53
87
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
19.9
19
*
R53
ICD-10 Finland
Malaise and fatigue
2.1
19.2
257
1404
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
20.5
19.1
28
14
SPAT1301
SPAT
No procedures
1.9
18.9
376
2390
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
18.9
234
1234
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
18.9
184
867
J01DB01
ATC
cefalexin; oral
2.0
18.5
843
7067
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
18.5
206
1035
N06AX11
ATC
mirtazapine; oral
1.9
18.4
351
2192
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
18.3
147
624
E66.00
ICD-10 Finland
Metabolic syndrome
4.2
18.2
70
174
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.0
18.2
45
67
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.8
17.9
77
213
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
17.8
259
1454
R06.0
ICD-10 Finland
Dyspnoea
2.0
17.6
289
1701
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
183.0
17.6
18
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
17.5
279
1626
SPAT1262
SPAT
Handing over of treatment supplies
2.1
17.1
208
1083
C07AB07
ATC
bisoprolol; oral
1.8
16.8
491
3506
N03AX09
ATC
lamotrigine; oral
4.1
16.6
66
170
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
172.6
16.5
17
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
16.5
212
1128
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
16.5
349
2244
G47.3
ICD-10 Finland
Sleep apnoea
2.2
16.4
188
952
N05AA02
ATC
levomepromazine; systemic
4.3
16.2
61
149
N30.0
ICD-10 Finland
Acute cystitis
2.1
16.0
201
1057
N06AX16
ATC
venlafaxine; oral
2.4
16.0
152
703
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
21.3
16.0
23
11
N05BA04
ATC
oxazepam; oral
1.9
15.8
282
1702
J01FF01
ATC
clindamycin; systemic
1.9
15.8
277
1660
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
15.8
173
856
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
15.7
15
*
24399
ICD-8 Finland
Cretinism of congenital origin
+∞
15.7
15
*
A10AA02
ATC
NA
4.1
15.6
61
155
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
7.2
15.4
37
53
N06AA09
ATC
amitriptyline; systemic
2.5
15.4
130
564
A06AD11
ATC
lactulose; oral
2.2
15.4
181
923
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
15.4
105
404
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
15.3
207
1122
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
9.9
15.2
30
31
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
15.2
423
2946
T90
ICPC
Diabetes non-insulin dependent
2.0
15.1
236
1354
H02AB09
ATC
hydrocortisone; systemic
6.1
15.1
41
70
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
15.0
438
3093
N06AB04
ATC
citalopram; systemic
1.9
14.9
241
1399
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
14.8
225
1275
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
9.9
14.7
29
30
E66.8
ICD-10 Finland
Other obesity
3.6
14.7
66
190
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
36.6
14.5
18
5
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
14.4
192
1035
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
14.4
407
2837
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
14.4
195
1056
N03AX12
ATC
gabapentin; oral
2.1
14.4
174
900
SPAT1153
SPAT
Removal of sutures
1.8
14.2
333
2188
N03AG01
ATC
valproic acid; systemic, rectal
3.2
14.2
75
245
R42
ICD-10 Finland
Dizziness and giddiness
1.9
14.1
262
1597
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
14.1
231
1345
H02AB06
ATC
prednisolone; systemic
1.7
14.1
473
3459
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
13.8
393
2730
J01DA01
ATC
[U] cefalexin; systemic
1.7
13.8
635
5050
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
13.8
340
2267
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
13.8
13.8
23
17
A28
ICPC
Limited function/disability NOS
2.0
13.8
200
1114
B03BA03
ATC
hydroxocobalamin; parenteral
3.2
13.7
74
245
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
13.7
120
533
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.9
13.6
85
311
A02BC05
ATC
esomeprazole; systemic
1.7
13.6
411
2903
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.7
13.6
59
165
E06.3
ICD-10 Finland
Autoimmune thyroiditis
76.1
13.6
15
*
A10AE06
ATC
insulin degludec; parenteral
5.4
13.6
40
76
L28
ICPC
Limited function/disability (L)
2.0
13.5
200
1120
N05CD07
ATC
temazepam; oral
2.2
13.5
147
726
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
13.4
315
2065
R03AC02
ATC
salbutamol; inhalant
1.6
13.3
536
4091
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
13.3
158
808
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
9.8
13.3
26
27
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.2
13.2
71
235
N02AX02
ATC
tramadol; systemic, rectal
1.7
13.1
421
3017
N05AN01
ATC
lithium; oral
6.1
13.1
35
59
N06AX21
ATC
duloxetine; oral
2.3
13.1
124
573
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
13.0
189
1050
SPAT1255
SPAT
Intravenous administration of medicine
2.8
13.0
85
321
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
12.8
163
858
SPAT1216
SPAT
Assessment of functional ability
2.0
12.8
192
1079
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
7.6
12.7
29
39
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
12.6
132
637
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
12.5
276
1768
2430A
ICD-9 Finland
Congenital hypothyroidism[HYPOTHYREOSIS CONGENITA]
+∞
12.5
12
*
E00.9
ICD-10 Finland
Congenital iodine-deficiency syndrome, unspecified
+∞
12.5
12
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
12.5
12
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.4
12.5
105
457
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.1
12.5
48
121
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.0
12.4
71
245
M25.5
ICD-10 Finland
Pain in joint
1.7
12.4
289
1882
P29
ICPC
Psychological sympt/compl other
3.0
12.4
72
252
N06AB03
ATC
fluoxetine; oral
2.1
12.2
145
741
N02AA05
ATC
oxycodone; systemic
2.0
12.2
165
890
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
12.2
75
272
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
12.1
112
509
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.9
12.0
209
1237
K29.4
ICD-10 Finland
Chronic atrophic gastritis
5.1
11.9
37
75
M79.6
ICD-10 Finland
Pain in limb
1.6
11.9
374
2645
N05AX08
ATC
risperidone; systemic
2.4
11.8
100
435
C10AA01
ATC
simvastatin; oral
1.6
11.8
439
3242
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
11.8
110
500
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.4
11.8
56
169
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
11.8
284
1862
2449X
ICD-9 Finland
Acquired hypothyroidism, Unspecified hypothyroidism
+∞
11.5
11
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
11.4
164
901
N06AB06
ATC
sertraline; oral
2.2
11.4
115
546
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
11.4
141
733
R60.0
ICD-10 Finland
Localized oedema
2.1
11.4
133
676
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.5
11.3
39
89
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
11.3
493
3782
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
11.2
182
1049
E0000UV
ATC
NA
1.6
11.2
398
2900
SPAT1260
SPAT
Consultation of another employee
1.9
11.1
191
1125
SPAT1097
SPAT
Recording of ECG
1.9
11.0
165
923
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
11.0
148
793
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.4
11.0
92
399
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
43.8
10.9
13
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
10.8
85
356
107
Kela drug reimbursment
Pernicious anaemia
5.3
10.8
32
62
R50.9
ICD-10 Finland
Fever, unspecified
2.0
10.8
148
799
H3600, E103
ICD-10 Finland
NA
9.0
10.8
22
25
E66.01
ICD-10 Finland
Obesity due to excess calories
2.5
10.7
85
359
A10BA02
ATC
metformin; oral
1.7
10.7
271
1795
P01AB01
ATC
metronidazole; oral, rectal
1.6
10.7
399
2933
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
60.6
10.6
12
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
10.6
158
881
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
10.6
237
1512
B81
ICPC
Anaemia vit B12/folate deficiency
3.7
10.6
46
130
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
9.3
10.5
21
23
WX110
NOMESCO Finland
Local anesthesy
1.6
10.5
659
5468
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
10.5
92
409
R03BA05
ATC
fluticasone; inhalant
1.8
10.5
191
1143
C10AA05
ATC
atorvastatin; oral
1.6
10.4
362
2605
J01MA02
ATC
ciprofloxacin; systemic
1.6
10.4
377
2745
SPAT1240
SPAT
Therapeutic discussion
2.2
10.4
113
554
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
10.4
10
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
10.4
267
1773
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
10.4
451
3433
B01AB05
ATC
enoxaparin; parenteral
1.6
10.4
310
2148
C09AA05
ATC
ramipril; oral
1.7
10.3
245
1593
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.1
10.3
123
630
N05BA01
ATC
diazepam; systemic, rectal
1.9
10.3
148
816
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
10.3
208
1287
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
10.2
144
786
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.4
10.2
90
402
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
10.2
192
1163
N03AE01
ATC
clonazepam; systemic
2.7
10.1
71
279
H02AB04
ATC
methylprednisolone; systemic
1.9
10.1
157
888
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.9
10.0
150
838
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
10.0
410
3067
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.0
10.0
144
790
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
10.0
125
651
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
40.5
10.0
12
*
A02BC01
ATC
omeprazole; systemic
1.6
9.9
294
2029
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
9.9
272
1837
N05BA06
ATC
lorazepam; systemic, sublingual
2.7
9.9
67
259
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
16.9
9.9
15
9
N05AH03
ATC
olanzapine; systemic
2.8
9.8
63
237
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
9.8
322
2281
N06AX03
ATC
mianserin; oral
2.8
9.7
61
225
K02.1
ICD-10 Finland
Caries of dentine
1.5
9.7
516
4091
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
9.7
166
970
M54.5
ICD-10 Finland
Low back pain
1.6
9.6
321
2278
AN1
HP
Coronary angiography
2.0
9.6
122
643
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
10.2
9.5
18
18
UJF32
NOMESCO Finland
Coloscopy
1.6
9.5
264
1785
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
9.5
117
607
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
100.9
9.4
10
*
R11
ICD-10 Finland
Nausea and vomiting
2.1
9.4
106
529
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.3
9.4
24
39
K59.1
ICD-10 Finland
Functional diarrhoea
2.6
9.4
68
274
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
9.4
9
*
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
9.4
9
*
ZX120
NOMESCO Finland
Intravenous
2.1
9.4
103
508
XF404
NOMESCO Finland
Ambulatory ECG
2.2
9.3
99
484
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
9.2
220
1429
M04AA01
ATC
allopurinol; systemic
2.0
9.2
123
659
A46
ICD-10 Finland
Erysipelas
1.9
9.2
141
795
C08CA01
ATC
amlodipine; oral
1.5
9.1
356
2621
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
9.1
170
1024
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
9.1
85
389
A41.9
ICD-10 Finland
Sepsis, unspecified
3.3
9.1
45
142
E66.9
ICD-10 Finland
Obesity, unspecified
3.4
9.1
42
126
P99
ICPC
Psychological disorders other
3.9
9.1
36
95
106
Kela drug reimbursment
Hypoparathyroidism
37.0
9.0
11
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.1
8.9
48
161
105
Kela drug reimbursment
Adrenal cortical hypofunction
18.8
8.9
13
7
SPAT1325
SPAT
Vaccination
1.5
8.9
361
2675
177
Kela drug reimbursment
Insulin glargine 300 U / ml
5.5
8.9
25
46
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.8
8.9
56
207
E000001
ATC
NA
1.7
8.8
209
1352
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
8.8
100
503
G44.2
ICD-10 Finland
Tension-type headache
1.8
8.7
145
840
R52.2
ICD-10 Finland
Other chronic pain
3.4
8.7
41
125
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
8.7
85
398
J01AA02
ATC
doxycycline; systemic
1.5
8.7
757
6609
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.9
8.7
52
188
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
8.6
206
1335
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
8.6
79
359
XCK10
NOMESCO Finland
Photography of fundus of eye
2.0
8.6
116
624
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
8.5
429
3328
EBA00
NOMESCO Finland
Extraction of tooth
1.6
8.5
297
2124
UKC02
NOMESCO Finland
Cystoscopy
1.8
8.4
142
824
SPAT1229
SPAT
Assessment of need for aid
2.1
8.4
99
504
SPAT1251
SPAT
Organisation of medication
2.8
8.4
53
197
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
8.4
54
204
A29
ICPC
General symptom/complaint other
1.9
8.4
122
673
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
8.4
94
469
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
8.3
8
*
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
8.3
8
*
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
8.3
8
*
R51.80
ICD-10 Finland
Headache
1.8
8.3
152
909
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.4
8.3
70
308
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
8.2
430
3356
D07AC01
ATC
betamethasone; topical
1.5
8.2
313
2280
P28
ICPC
Limited function/disability (P)
7.6
8.2
18
24
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.4
8.2
68
294
C03DA01
ATC
spironolactone; oral
1.9
8.1
115
631
P03
ICPC
Feeling depressed
2.1
8.1
92
460
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.0
8.1
103
542
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
4.5
8.1
27
61
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
10.1
8.0
15
15
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
22.2
8.0
11
5
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.9
8.0
47
168
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
8.0
76
354
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
8.0
78
367
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
8.0
500
4041
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
5.0
7.9
24
49
A10BB12
ATC
glimepiride; oral
2.2
7.9
75
348
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.9
252
1759
H02AB07
ATC
prednisone; oral
1.8
7.9
146
874
R02
ICPC
Shortness of breath/dyspnoea
1.8
7.9
129
742
F60.8
ICD-10 Finland
Other specific personality disorders
13.1
7.9
13
10
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
5.2
7.9
23
45
SPAT1104
SPAT
Monitoring of emergency patient
2.2
7.9
75
349
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.2
7.9
79
374
A02BA02
ATC
ranitidine; systemic
1.6
7.9
210
1401
M01AH01
ATC
celecoxib; oral (coxibs)
1.7
7.8
185
1194
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.8
7.8
47
171
SPAT1211
SPAT
Application of soft bandage
2.0
7.8
99
521
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.3
7.7
27
64
N05AB03
ATC
perphenazine; systemic, rectal
3.1
7.7
40
132
2504
FHL
Unilateral resection or enucleation
45.3
7.7
9
*
R39.1
ICD-10 Finland
Other difficulties with micturition
3.7
7.7
32
89
A02BC03
ATC
lansoprazole; oral
1.5
7.7
290
2102
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.5
7.7
57
234
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
7.6
205
1369
D02AE01
ATC
carbamide; topical
2.2
7.6
71
328
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
7.6
123
704
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
7.6
267
1906
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
8.9
7.6
15
17
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.0
7.6
93
484
SPAT1310
SPAT
Counselling related to known health issue
1.5
7.5
311
2299
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
7.5
211
1425
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.2
7.5
75
357
WX722
NOMESCO Finland
PEEP
2.7
7.5
48
181
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
7.5
480
3879
E10
ICD-10 Finland
Type 1 diabetes mellitus
4.9
7.5
23
48
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
7.5
104
566
T82
ICPC
Obesity
3.0
7.5
41
141
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
7.5
106
582
L03
ICPC
Low back symptom/complaint
1.6
7.5
239
1667
A04
ICPC
Weakness/tiredness general
1.7
7.4
144
877
N05AF03
ATC
chlorprothixene; systemic
3.8
7.4
29
77
K90
ICPC
Stroke/cerebrovascular accident
3.2
7.4
36
114
SPAT1252
SPAT
Overall medication plan or its review
2.2
7.4
76
367
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.3
647
5545
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
7.3
87
445
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.0
7.3
93
488
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
7.3
131
777
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.0
7.3
22
45
UJD02
NOMESCO Finland
Gastroscopy
2.5
7.3
54
221
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
7.3
7
*
2506
FHL
Thyroidectomy
+∞
7.3
7
*
D11
ICPC
Diarrhoea
1.9
7.3
112
632
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.5
7.3
24
54
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
7.3
211
1433
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.8
7.3
43
155
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.5
7.2
54
223
J01EA01
ATC
trimethoprim; systemic
1.5
7.2
301
2227
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.6
7.2
50
198
C07AA05
ATC
propranolol; systemic
1.6
7.2
180
1178
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.1
7.2
81
404
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.9
7.2
109
613
A05
ICPC
Feeling ill
2.2
7.1
67
309
RJ210
NOMESCO Finland
NA
20.2
7.1
10
5
A10BK01
ATC
dapagliflozin; oral
2.9
7.1
41
144
N05AC02
ATC
thioridazine; oral
4.2
7.1
25
60
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
7.1
184
1216
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
7.1
182
1196
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.0
7.1
93
494
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
5.7
7.1
19
34
M70.6
ICD-10 Finland
Trochanteric bursitis
1.7
7.1
137
832
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.9
7.0
41
146
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.1
7.0
74
361
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.1
7.0
78
388
N06AB05
ATC
paroxetine; oral
2.3
7.0
59
260
ZXA00
NOMESCO Finland
Right side
1.5
7.0
277
2021
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.4
7.0
32
97
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
4.3
6.9
24
57
SPAT1266
SPAT
Separate instruction to prepare for procedure
3.2
6.9
34
109
UJF30
NOMESCO Finland
Ileoscopy through colon
1.9
6.9
92
494
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
6.9
70
334
A01
ICPC
Pain general/multiple sites
2.0
6.9
82
422
L16
ICPC
Ankle symptom/complaint
1.9
6.9
105
592
P72
ICPC
Schizophrenia
4.8
6.9
21
44
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.7
6.9
44
166
H25.8
ICD-10 Finland
Other senile cataract
1.8
6.8
127
762
S06.0
ICD-10 Finland
Concussion
1.8
6.8
108
615
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
6.8
6.8
16
24
J01CA08
ATC
pivmecillinam; oral
1.4
6.8
479
3915
N30.9
ICD-10 Finland
Cystitis, unspecified
2.1
6.8
74
364
N05BA12
ATC
alprazolam; oral
1.9
6.8
99
549
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.8
6.8
40
144
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.4
6.8
55
238
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.4
6.8
31
94
N06AX26
ATC
vortioxetine; oral
2.4
6.8
52
219
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
5.7
6.8
18
32
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
40.3
6.8
8
*
RJ630
NOMESCO Finland
NA
40.3
6.8
8
*
A11CC02
ATC
dihydrotachysterol; oral
40.3
6.8
8
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
16.8
6.7
10
6
WX882
NOMESCO Finland
High dependency care
3.1
6.7
35
117
XX9LA
NOMESCO Finland
Complementary kinetic X-ray examination without contrast
7.2
6.7
15
21
S97
ICPC
Chronic ulcer skin
2.3
6.7
59
265
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.7
583
4946
SPAT1312
SPAT
General health counselling
1.5
6.7
312
2356
N06AB10
ATC
escitalopram; oral
1.6
6.7
181
1210
N06AX12
ATC
bupropion; oral
2.6
6.7
47
188
M01AE02
ATC
naproxen; oral, rectal
1.4
6.7
525
4373
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.2
6.6
67
322
R05
ICD-10 Finland
Cough
1.6
6.6
186
1254
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
6.6
77
391
A08
ICPC
Swelling
2.4
6.6
53
228
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
6.6
79
405
N04AA02
ATC
biperiden; systemic
4.4
6.6
22
51
R4110
SPAT
NA
2.9
6.6
36
125
S18
ICPC
Laceration/cut
1.4
6.5
381
3001
WX290
NOMESCO Finland
Other blockade of nerve
1.4
6.5
360
2805
160
Kela drug reimbursment
exenatide
4.2
6.5
23
56
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.1
6.5
68
331
J01CA04
ATC
amoxicillin; systemic
1.5
6.5
786
7059
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.9
6.5
87
468
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
5.1
6.5
19
38
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
6.5
100
565
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.7
6.5
40
150
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
6.5
82
430
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
70.3
6.4
7
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.6
6.4
27
77
P73
ICPC
Affective psychosis
14.4
6.4
10
7
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
6.4
78
405
Z00.0
ICD-10 Finland
General medical examination
1.6
6.4
172
1145
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
4.9
6.4
19
39
N05AH02
ATC
clozapine; systemic
4.9
6.4
19
39
-50
ICPC
Medication/prescr/renewal
2.5
6.4
46
188
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.2
6.4
60
280
SPAT1281
SPAT
Other administrative function
1.9
6.3
84
451
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
8.2
6.3
13
16
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
5.2
6.3
18
35
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.1
6.3
69
343
C07AB02
ATC
metoprolol; systemic
1.5
6.3
213
1496
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
5.6
6.3
17
31
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
6.3
41
157
RJ411
NOMESCO Finland
NA
11.1
6.3
11
10
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
6.3
57
261
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
18.1
6.3
9
5
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
6.3
6
*
2440A
ICD-9 Finland
Acquired hypothyroidism, Postsurgical hypothyroidism
+∞
6.3
6
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
6.3
6
*
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
6.3
6
*
E00.0
ICD-10 Finland
Congenital iodine-deficiency syndrome, neurological type
+∞
6.3
6
*
A10BH01
ATC
sitagliptin; oral
1.9
6.2
87
476
RK112
NOMESCO Finland
NA
26.8
6.2
8
*
R32
ICD-10 Finland
Unspecified urinary incontinence
2.8
6.2
37
135
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
6.2
66
325
M01AH02
ATC
rofecoxib; oral
1.7
6.2
134
839
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.0
6.2
74
381
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.5
6.2
47
197
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.9
6.1
90
502
RS221
NOMESCO Finland
NA
4.1
6.1
22
55
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.8
6.1
24
65
R52.9
ICD-10 Finland
Pain, unspecified
1.9
6.1
82
443
Z25.1
ICD-10 Finland
Need for immunization against influenza
2.3
6.1
53
239
R96
ICPC
Asthma
1.9
6.1
87
479
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
6.1
105
616
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
4.4
6.1
20
46
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.7
6.1
115
694
SPAT1234
SPAT
Support of social functional capacity
2.1
6.0
62
299
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
10.1
6.0
11
11
C03AA03
ATC
hydrochlorothiazide; oral
1.8
6.0
103
602
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
6.0
332
2581
H02AA02
ATC
fludrocortisone; oral
5.6
6.0
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
192
277
8.13
130.46
3.3
1.5
4.3
4.5
pmol/l
1.53
172
235
1022
6876
5.73
84.30
9.9
2.6
16.2
14.5
pmol/l
63.67
951
6132
440
2442
2.31
38.52
2.4
2.3
3.2
3.1
mg/l
0.51
389
2072
754
5247
2.29
37.55
6.3
4.2
7.1
6.7
mmol/l
4.29
722
4863
687
4603
2.24
37.55
8.5
5.8
1.2
1.2
mmol/l
0.33
572
3851
1032
8383
3.46
35.82
11.5
3.5
2.0
1.9
mu/l
0.39
959
7576
427
2429
2.21
34.37
4.9
4.0
—
—
—
0
0
457
2727
2.13
32.05
2.4
2.1
146.9
200.3
u/l
1.51
433
2556
538
3440
2.07
31.10
5.6
3.8
38.6
45.9
ng/l
0.27
404
2397
676
4706
2.07
30.85
6.6
5.5
11.2
11.1
umol/l
0.02
644
4428
557
3621
2.05
30.62
9.8
9.5
1.2
1.2
inr
0.09
153
1003
630
4301
2.04
30.02
7.4
5.4
57.0
57.6
%
0.71
585
3992
149
556
2.93
29.29
3.8
3.9
5.2
5.2
kpa
0.04
143
515
589
3950
2.02
29.23
2.8
2.3
78.5
77.6
nmol/l
0.28
531
3525
453
2768
2.06
29.15
3.5
2.2
58.5
57.5
u/l
0.06
435
2533
609
4137
2.01
29.09
7.7
5.2
1.2
1.2
mmol/l
0.47
555
3690
574
3822
2.01
28.99
2.3
2.0
98.8
94.6
pmol/l
1.04
306
1898
263
1301
2.33
28.94
2.4
2.2
2.4
2.3
g/l
0.26
237
1195
147
548
2.93
28.94
3.7
4.0
7.4
7.4
ph
0.56
15
66
632
4367
2.00
28.56
7.8
5.7
28.0
27.7
%
0.22
581
4039
279
1425
2.27
28.41
2.6
2.2
11.8
12.5
umol/l
0.79
262
1304
618
4257
1.99
27.96
8.0
5.8
8.4
8.4
%
0.05
574
3952
598
4073
1.99
27.95
3.4
2.7
107.5
107.2
ug/l
0.01
557
3742
332
1834
2.14
27.71
2.1
1.8
1219.9
1179.7
nmol/l
0.25
244
1351
643
4513
1.98
27.29
7.2
5.4
0.0
0.0
e9/l
0.58
562
3882
613
4241
1.96
27.05
7.7
5.5
2.9
2.7
%
0.65
566
3912
421
2570
2.01
26.61
5.2
3.9
—
—
—
0
0
652
4625
1.96
26.52
7.2
5.4
1.9
1.9
e9/l
0.26
582
4061
824
6349
2.08
26.31
7.7
4.8
760.8
3215.7
e6/l
1.35
49
86
636
4489
1.94
26.08
7.2
5.4
0.6
0.6
e9/l
1.81
562
3856
595
4117
1.93
25.80
7.7
5.6
0.6
0.7
%
0.41
552
3804
348
2005
2.06
25.66
1.9
1.7
82414218.5
32061042.0
pmol/l
0.37
290
1650
435
2715
1.97
25.58
4.1
3.0
1654.4
1491.8
ng/l
0.34
381
2304
651
4678
1.91
24.78
7.5
5.7
0.2
0.2
e9/l
0.84
582
4080
191
875
2.42
24.72
6.1
3.9
—
—
—
0
0
502
3337
1.90
24.06
4.0
3.4
—
—
—
0
0
237
1212
2.21
23.62
2.5
2.3
19.9
21.8
%
1.44
206
1035
462
3021
1.89
23.03
7.2
5.5
—
—
—
0
0
568
3996
1.84
22.18
5.4
4.2
34.3
35.3
g/l
3.72
534
3689
228
1177
2.17
22.06
26.7
25.3
1.3
1.3
inr
0.07
40
144
49
105
4.83
21.65
1.9
1.2
3.8
2.2
iu/l
0.83
21
16
818
6478
1.93
21.60
6.6
4.6
—
—
—
0
0
425
2757
1.86
21.33
4.4
3.2
38.7
83.9
e6/l
0.91
346
2093
865
7003
1.98
21.07
9.8
6.8
83.8
79.3
u/l
1.45
832
6525
168
781
2.35
20.85
2.1
1.8
361.8
373.7
nmol/l
0.31
157
703
404
2606
1.85
20.45
4.2
3.0
6.3
6.8
mmol/l
1.64
335
2161
248
1364
2.05
20.14
3.2
3.0
0.8
0.8
mmol/l
0.66
234
1265
213
1114
2.12
19.76
6.9
4.8
1.1
1.1
mmol/l
0.35
203
1028
478
3283
1.79
19.42
5.2
3.7
85.3
113.9
e6/l
0.48
366
2256
380
2440
1.84
19.30
4.3
3.1
504.3
352.0
mg/l
0.24
261
1495
395
2578
1.81
18.94
5.1
3.8
12.9
9.4
mg/mmol
0.69
277
1565
317
1935
1.88
18.83
3.8
2.5
7.4
7.4
e6/l
0.02
280
1677
684
5267
1.75
18.13
11.2
8.3
4.2
4.1
e9/l
0.86
618
4558
832
6797
1.83
17.81
6.1
4.0
14.3
13.1
mm/h
1.53
781
6243
329
2069
1.83
17.59
1.4
1.3
1.8
1.6
u/ml
0.14
91
514
209
1135
2.03
17.36
1.3
1.3
477.3
608.9
titre
0.48
45
238
196
1060
2.03
16.40
2.6
2.5
1.9
1.8
%
0.89
171
916
334
2151
1.78
16.30
2.9
2.5
5716.0
7710.2
umol/l
0.30
280
1850
424
2924
1.72
16.23
2.6
2.3
—
—
—
0
0
138
655
2.26
16.16
5.7
3.2
—
—
—
0
0
192
1037
2.02
16.11
2.1
1.7
—
—
—
0
0
573
4293
1.67
15.97
5.2
3.9
—
—
—
0
0
284
1752
1.83
15.95
1.5
1.5
2.1
2.3
g/l
1.14
151
1030
97
401
2.55
15.43
4.1
4.2
—
—
—
0
0
292
1845
1.78
15.02
3.6
2.8
533.5
532.6
mosm/kgh2o
0.02
255
1554
66
227
3.02
14.88
4.6
3.6
22.2
27.1
mg/l
0.58
52
143
337
2231
1.73
14.67
1.7
1.5
19.8
20.9
nmol/l
0.65
283
1861
361
2440
1.70
14.54
5.3
3.6
—
—
—
0
0
86
347
2.60
14.38
2.4
2.0
1.2
2.5
ug/l
0.80
70
298
209
1220
1.87
13.81
1.2
1.2
—
—
—
0
0
121
585
2.20
13.49
3.7
2.7
4.7
4.0
e9/l
1.09
88
437
449
3274
1.61
13.14
3.1
3.3
2.3
2.4
mmol/l
3.56
373
2813
83
345
2.52
13.06
4.3
4.5
24.8
24.9
mmol/l
0.17
77
326
933
8150
1.80
12.97
8.6
5.5
43.1
39.7
mmol/mol
13.38
851
7495
104
483
2.27
12.78
1.3
1.3
—
—
—
0
0
34
84
4.14
12.63
1.4
1.3
—
—
—
0
0
580
4539
1.57
12.27
5.2
3.9
0.0
0.0
estimate
0.00
95
827
172
979
1.89
12.20
2.5
2.7
7.2
7.3
umol/l
0.02
149
834
299
2011
1.66
11.88
6.0
4.3
1.0
1.0
kg/l
0.22
68
298
1015
9165
1.99
11.87
24.4
13.9
20.7
23.8
mg/l
2.96
902
7239
134
709
2.01
11.76
7.9
6.2
11.3
9.5
mmol/l
1.91
128
671
201
1218
1.79
11.63
2.3
1.9
—
—
—
0
0
584
4631
1.54
11.28
5.4
4.0
0.0
0.0
estimate
0.80
105
816
1026
9344
1.99
11.01
27.7
15.9
139.2
139.6
mmol/l
4.22
1010
9073
133
720
1.96
10.92
4.2
3.5
116.0
85.5
ng/l
1.40
107
614
239
1549
1.69
10.83
1.5
1.3
45.1
36.1
iu/ml
0.39
77
498
1026
9362
1.97
10.68
28.0
16.0
4.0
4.0
mmol/l
0.71
1008
9065
166
973
1.83
10.67
1.5
1.4
—
—
—
0
0
117
617
2.00
10.35
2.5
2.8
10.5
10.4
g/l
0.16
105
561
53
198
2.76
10.34
2.2
2.3
127.8
126.3
g/l
0.14
38
145
88
417
2.20
10.30
1.9
1.7
1.6
1.5
g/l
0.12
65
360
91
438
2.17
10.25
1.4
1.2
255.7
71.3
iu/ml
3.69
50
139
340
2435
1.56
10.18
5.1
4.3
0.0
0.0
estimate
1.08
104
814
572
4584
1.50
10.07
7.4
5.4
0.0
0.0
estimate
0.50
104
829
135
755
1.89
10.05
2.5
2.6
64.1
66.4
g/l
2.68
117
685
48
174
2.84
9.91
2.8
2.5
207.4
88.2
ug/min
0.95
31
99
71
315
2.34
9.72
2.5
3.3
0.3
0.3
g/l
0.03
29
117
226
1494
1.64
9.37
1.4
1.2
12.7
11.7
u/ml
0.07
83
558
277
1932
1.57
9.17
4.7
4.4
—
—
—
0
0
41
144
2.92
8.98
1.7
1.4
—
—
—
0
0
135
784
1.82
8.90
2.7
2.5
73.8
70.7
e9/l
0.37
108
588
12
6
20.19
8.48
4.3
1.8
—
—
—
0
0
33
107
3.15
8.30
22.9
5.0
7.9
7.4
mmol/l
0.25
28
85
26
73
3.62
8.16
3.3
2.3
—
—
—
0
0
126
737
1.80
8.11
5.2
3.9
0.7
0.9
%
0.50
46
209
149
916
1.72
8.07
1.3
1.3
—
—
—
0
0
205
1369
1.61
8.07
2.1
1.9
30.1
29.6
s
0.71
199
1317
139
845
1.73
7.83
2.8
2.2
0.2
0.2
g/l
0.35
125
802
286
2071
1.51
7.83
1.7
1.7
1.0
1.2
mg/l
1.04
222
1570
24
66
3.69
7.76
3.8
2.8
24.8
13.3
mg/l
0.30
19
46
120
701
1.80
7.75
5.3
4.0
0.1
0.1
%
0.58
43
191
55
245
2.31
7.51
1.4
1.4
261.3
306.6
ug/g
1.03
35
133
31
105
3.01
7.27
1.4
1.2
—
—
—
0
0
43
174
2.53
7.24
3.9
3.5
—
—
—
0
0
15
30
5.05
7.19
3.4
2.6
—
—
—
0
0
11
16
6.93
7.16
4.5
3.4
—
—
—
0
0
40
161
2.54
6.82
2.8
2.7
—
—
—
0
0
78
414
1.95
6.80
1.9
1.9
—
—
—
0
0
121
736
1.72
6.80
1.3
1.2
—
—
—
0
0
11
17
6.52
6.78
1.4
1.4
—
—
—
0
0
203
1411
1.53
6.64
3.4
2.9
3.9
3.6
e6/l
0.13
121
753
948
8710
1.53
6.56
5.9
4.3
6.2
5.9
mmol/l
6.15
871
7842
110
659
1.74
6.53
5.5
4.1
0.4
0.1
%
0.51
38
160
80
435
1.90
6.51
10.1
7.9
—
—
—
0
0
243
1761
1.48
6.50
5.2
3.6
387.0
270.8
ng/l
0.18
188
1359
22
66
3.38
6.29
1.1
2.0
11.7
12.1
%
—
10
35
57
278
2.11
6.28
6.3
5.4
1.5
1.3
mmol/l
0.69
52
245
132
841
1.64
6.24
7.5
6.4
94.0
95.4
%
1.38
126
810
135
868
1.63
6.15
3.9
3.7
1.8
1.9
mmol/l
0.08
106
688
347
2714
1.40
6.10
5.6
3.5
7.4
7.4
ph
0.71
79
505
10
8
12.60
6.08
2.4
1.6
11.0
14.8
umol/l
—
10
8
45
202
2.28
6.08
1.3
1.6
428.4
502.7
mg/l
0.95
40
189
24
78
3.12
6.06
1.6
2.2
1.5
1.1
e9/l
0.46
14
50
1022
9608
1.62
5.75
14.7
9.8
25.2
23.7
u/l
0.90
994
9248
12
24
5.04
5.75
1.8
2.0
—
—
—
0
0
118
751
1.64
5.60
2.7
2.4
5.1
5.9
ug/l
0.37
92
639
108
672
1.67
5.60
4.4
3.8
0.6
0.6
%
0.04
28
152
13
29
4.52
5.52
3.5
2.9
—
—
—
0
0
85
499
1.76
5.44
1.6
1.9
1.2
1.7
g/l
1.48
76
454
104
654
1.65
5.19
2.3
2.3
—
—
—
0
0
132
881
1.56
5.15
1.6
1.5
—
—
—
0
0
286
2219
1.39
5.15
2.6
2.2
—
—
—
0
0
319
2520
1.37
5.14
4.1
3.1
0.5
0.5
e6/l
0.07
248
1898
939
8720
1.44
5.10
5.6
4.1
4.6
4.7
mmol/l
4.33
863
7988
54
280
1.97
5.09
4.4
5.4
—
—
—
0
0
38
172
2.25
5.08
4.7
3.8
2.8
2.8
mmol/l
0.00
31
116
39
179
2.22
5.05
1.8
1.9
193.7
1795.5
e6/l
0.57
34
142
39
179
2.22
5.05
1.6
1.8
3.1
17.6
e6/l
1.49
34
134
18
55
3.31
5.04
1.7
2.2
0.2
0.2
e9/l
0.22
13
47
29
117
2.52
4.98
1.6
1.3
24.0
22.9
u/l
0.07
23
97
154
1071
1.51
4.98
2.1
2.4
171.2
110.2
ug/g
0.71
121
831
903
8341
1.40
4.95
5.1
3.7
1.4
1.2
mmol/l
5.97
816
7535
142
973
1.52
4.93
7.6
6.1
1.2
1.2
mmol/l
0.02
112
755
31
130
2.42
4.92
3.1
3.1
1.1
1.8
%
0.58
25
102
13
32
4.10
4.90
2.0
4.9
313.7
168.8
umol/l
—
7
23
24
89
2.73
4.86
4.5
6.2
12.3
12.0
mg/l
0.13
17
80
120
800
1.56
4.71
3.4
2.9
217.4
221.4
ng/l
0.04
110
731
27
109
2.51
4.65
2.8
2.9
—
—
—
0
0
18
58
3.14
4.65
1.7
2.2
649.8
477.0
e6/l
0.48
12
48
1061
10144
1.67
4.64
35.6
20.4
7.0
6.7
e9/l
3.17
1041
9818
22
80
2.78
4.63
2.1
1.4
—
—
—
0
0
52
276
1.93
4.61
2.2
2.6
—
—
—
0
0
141
979
1.50
4.60
7.7
6.1
5.0
5.1
kpa
0.44
135
933
141
980
1.50
4.58
7.7
6.1
11.5
12.2
kpa
0.82
134
938
42
207
2.07
4.57
4.8
3.5
7.4
7.4
ph
0.03
37
170
1060
10139
1.66
4.53
35.6
20.3
257.4
255.1
e9/l
0.52
1044
9850
1060
10141
1.65
4.50
35.4
20.3
30.0
30.2
pg
3.30
1052
9972
1060
10142
1.65
4.49
35.6
20.3
4.4
4.4
e12/l
1.63
1040
9820
929
8662
1.39
4.48
5.7
4.1
1.5
1.5
mmol/l
6.06
845
7893
16
49
3.30
4.48
1.8
1.8
2.0
2.4
u/field
—
10
35
1060
10145
1.65
4.44
35.8
20.5
129.7
131.8
g/l
5.28
1050
9975
23
88
2.65
4.41
4.0
3.7
—
—
—
0
0
24
94
2.59
4.40
2.5
2.4
0.6
2.1
u/field
—
9
30
952
8921
1.41
4.39
6.1
4.6
2.6
2.7
mmol/l
3.93
872
8132
73
438
1.71
4.37
1.3
1.4
32.3
29.4
iu/l
0.28
66
378
21
77
2.76
4.36
1.8
2.0
—
—
—
0
0
306
2455
1.34
4.36
4.0
3.1
—
—
—
0
0
59
333
1.81
4.35
2.3
2.1
403.4
4079.9
u/l
2.24
22
144
1059
10140
1.63
4.34
35.5
20.3
90.7
91.0
fl
1.22
1051
9973
21
78
2.72
4.27
1.1
1.1
—
—
—
0
0
1003
9499
1.47
4.26
23.8
13.1
—
—
—
0
0
11
27
4.10
4.16
1.2
1.3
—
—
—
0
0
24
98
2.48
4.07
1.3
1.1
—
—
nmol/l
—
0
0
137
971
1.47
4.04
3.5
4.0
24.4
22.6
ug/l
0.03
104
799
431
3668
1.28
3.90
2.2
2.1
—
—
—
0
0
27
119
2.30
3.89
1.4
1.1
0.6
0.6
nmol/l
0.19
27
109
52
293
1.81
3.88
4.8
3.3
239.1
92.1
mg/l
0.53
39
230
52
294
1.81
3.84
4.8
3.3
27.7
46.0
mg/l
0.86
39
230
29
134
2.19
3.76
1.1
1.5
—
—
—
0
0
85
555
1.57
3.69
5.2
4.4
—
—
—
0
0
79
508
1.60
3.66
2.8
2.4
—
—
—
0
0
33
163
2.06
3.63
1.8
1.9
—
—
—
0
0
15
51
2.97
3.58
1.4
1.1
241.3
224.3
mg/l
0.15
15
42
7
9
7.82
3.56
3.6
2.4
—
—
—
0
0
62
380
1.67
3.48
5.9
4.3
1.7
1.5
%
0.76
57
359
457
3964
1.26
3.41
13.9
9.2
0.0
0.0
e9/l
1.26
380
3227
108
757
1.47
3.39
3.0
3.2
4.8
4.5
kpa
1.02
102
732
9
18
5.03
3.37
1.2
1.9
—
—
—
0
0
16
59
2.74
3.33
3.3
2.6
—
—
—
0
0
277
2267
1.29
3.32
1.8
1.6
1.4
1.3
mmol/l
1.14
248
1913
32
162
2.00
3.32
1.7
1.6
—
—
—
0
0
106
745
1.47
3.29
4.9
3.5
1.2
1.2
mmol/l
0.88
100
645
18
72
2.52
3.22
1.4
1.3
—
—
—
0
0
24
111
2.19
3.14
1.4
1.1
—
—
—
0
0
12
39
3.10
3.09
3.7
1.5
—
—
—
0
0
24
478
0.49
3.09
1.4
1.4
—
—
—
0
0
5
5
10.04
2.98
1.0
1.0
—
—
—
0
0
17
69
2.49
2.96
1.9
1.4
32.2
28.4
%
0.15
12
43
13
46
2.85
2.92
10.3
15.5
—
—
—
0
0
10
30
3.35
2.91
1.1
1.2
89.8
82.4
mg/l
—
5
18
10
30
3.35
2.91
1.0
1.8
—
—
—
0
0
42
694
0.59
2.90
1.5
1.3
—
—
—
0
0
106
766
1.42
2.87
7.3
5.6
1.6
1.3
mmol/l
0.57
96
736
87
607
1.47
2.83
1.6
1.4
—
—
—
0
0
59
379
1.59
2.80
6.1
4.3
0.9
0.9
%
0.05
54
357
139
1056
1.36
2.80
7.0
5.6
104.5
104.0
mmol/l
0.33
131
1034
112
821
1.40
2.80
4.3
2.1
34.8
38.8
u/l
0.31
93
685
163
1270
1.33
2.78
1.7
1.6
—
—
—
0
0
22
104
2.14
2.76
2.0
1.6
61.7
62.5
%
0.03
15
67
37
213
1.76
2.66
5.1
3.4
—
—
—
0
0
37
215
1.75
2.58
1.8
1.7
14018.9
13343.9
e6/l
0.03
27
156
276
2328
1.24
2.53
7.7
6.3
—
—
—
0
0
100
733
1.40
2.52
8.4
6.9
—
—
—
0
0
51
328
1.58
2.44
1.2
1.3
0.2
1.2
u/ml
—
5
27
57
379
1.53
2.37
2.3
1.4
—
—
—
0
0
266
2252
1.24
2.34
4.5
3.6
90.0
91.5
%
0.37
255
2191
40
245
1.66
2.34
1.3
1.3
—
—
—
0
0
17
79
2.17
2.25
1.5
1.3
142786.7
126544.5
e6/l
0.04
12
49
10
36
2.79
2.20
2.2
1.3
3.2
1.0
%
—
5
6
25
136
1.86
2.19
2.2
2.6
—
—
—
0
0
71
504
1.44
2.17
1.4
1.3
—
35.8
—
0
25
26
144
1.82
2.16
1.8
1.5
—
—
—
0
0
6
14
4.30
2.15
1.2
1.4
93.2
80.0
ng/l
—
6
14
16
74
2.18
2.15
1.5
1.1
—
—
—
0
0
8
25
3.22
2.09
1.0
1.0
1357.3
1645.8
miu/ml
—
8
25
72
519
1.41
2.04
3.8
4.0
—
—
—
0
0
26
147
1.79
2.03
3.8
2.4
—
—
—
0
0
14
65
2.17
1.88
1.2
1.2
—
—
—
0
0
29
174
1.68
1.87
3.1
2.5
17.1
15.7
%
1.53
17
92
17
86
1.99
1.85
1.4
1.3
42590.8
43382.2
e6/l
0.01
11
53
17
86
1.99
1.85
1.6
1.3
—
—
—
0
0
11
46
2.40
1.85
1.5
1.3
—
—
—
0
0
10
40
2.51
1.84
6.8
4.2
—
—
—
0
0
18
94
1.93
1.80
1.1
1.1
—
—
—
0
0
16
80
2.01
1.80
2.4
2.2
—
—
—
0
0
7
23
3.06
1.80
1.4
1.6
—
—
—
0
0
13
60
2.18
1.78
1.2
1.1
—
—
—
0
0
22
125
1.77
1.72
1.6
1.5
112.5
111.4
u/ml
—
8
30
73
548
1.35
1.67
1.2
1.4
—
—
—
0
0
21
120
1.76
1.63
1.0
1.1
15.6
4629.8
iu/ml
—
5
28
95
745
1.30
1.62
1.5
1.4
—
—
—
0
0
5
14
3.58
1.61
1.0
1.0
—
—
—
0
0
10
43
2.34
1.60
1.2
1.3
—
—
—
0
0
8
32
2.51
1.60
1.0
1.2
—
—
—
0
0
94
743
1.29
1.52
3.1
3.7
—
—
—
0
0
6
21
2.87
1.50
2.8
1.3
—
—
—
0
0
27
171
1.59
1.47
5.0
2.0
1.0
0.8
nmol/l
0.41
20
141
10
45
2.23
1.46
6.8
3.8
—
—
—
0
0
659
6213
1.14
1.46
4.4
3.7
—
—
—
0
0
32
212
1.52
1.44
1.5
1.5
—
—
—
0
0
6
22
2.74
1.43
1.3
1.2
—
—
—
0
0
40
280
1.44
1.39
2.1
2.0
10.0
11.1
nmol/l
0.25
33
247
17
96
1.78
1.39
1.4
1.3
—
—
—
0
0
17
96
1.78
1.39
1.4
1.3
—
—
—
0
0
17
96
1.78
1.39
1.4
1.3
—
—
—
0
0
17
96
1.78
1.39
1.4
1.3
—
—
—
0
0
18
104
1.74
1.37
1.8
2.4
—
—
—
0
0
23
143
1.62
1.36
1.1
1.3
242.4
272.2
u/ml
0.18
12
76
19
112
1.71
1.36
2.2
2.8
—
—
—
0
0
34
232
1.48
1.35
4.0
3.2
1.0
0.9
nmol/l
1.39
26
182
51
376
1.37
1.34
1.2
1.2
—
—
—
0
0
42
300
1.42
1.33
2.7
2.1
37.0
37.3
g/l
0.11
32
254
38
267
1.44
1.31
1.1
1.3
189.5
233.1
miu/ml
0.34
22
125
6
24
2.51
1.30
1.2
1.1
—
—
—
0
0
14
78
1.80
1.21
1.2
1.2
—
—
—
0
0
15
86
1.75
1.19
2.0
1.4
—
—
—
0
0
18
109
1.66
1.19
4.3
1.7
—
—
—
0
0
17
102
1.68
1.16
3.5
1.5
283.5
276.7
mosm/kgh2o
0.57
11
70
0
34
0.00
1.16
0.0
1.5
—
—
—
0
0
13
72
1.81
1.15
1.5
1.2
—
—
—
0
0
28
192
1.47
1.12
1.5
1.4
60.5
60.8
mmol/l
0.02
20
152
15
88
1.71
1.11
1.5
1.5
—
—
—
0
0
10
51
1.97
1.11
1.0
1.0
693.2
601.1
ng/l
—
5
27
13
73
1.79
1.11
1.3
1.1
3.1
1.6
u/ml
—
6
30
5
21
2.39
1.09
1.2
1.6
—
—
—
0
0
5
21
2.39
1.09
1.4
1.3
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
172
1506
1.17
1.08
1.9
1.8
—
—
—
0
0
7
33
2.13
1.05
1.3
1.3
—
—
—
0
0
28
196
1.44
1.03
3.1
1.5
—
—
—
0
0
12
202
0.59
1.02
1.4
1.5
—
—
—
0
0
26
180
1.45
1.01
2.5
3.1
4.5
4.3
e9/l
0.11
26
180
15
91
1.66
1.00
4.1
1.7
—
—
—
0
0
7
35
2.01
1.00
3.0
1.7
—
—
—
0
0
7
35
2.01
1.00
1.0
1.0
—
—
—
0
0
19
123
1.55
1.00
1.2
1.0
—
—
—
0
0
9
50
1.81
0.96
1.6
1.9
—
—
—
0
0
26
182
1.44
0.96
3.9
3.2
—
—
—
0
0
25
174
1.45
0.95
3.4
1.8
—
—
—
0
0
12
197
0.60
0.94
1.3
1.4
—
—
—
0
0
12
196
0.61
0.92
1.3
1.4
—
—
—
0
0
126
1097
1.17
0.87
1.3
1.3
—
—
—
0
0
204
1841
1.13
0.86
3.1
2.8
2.5
2.5
mmol/l
0.43
166
1604
17
112
1.53
0.85
1.2
1.1
—
—
—
0
0
27
196
1.39
0.84
1.2
1.1
—
—
—
0
0
19
129
1.48
0.83
1.2
1.2
—
—
—
0
0
41
319
1.30
0.83
1.1
1.1
—
—
—
0
0
90
766
1.19
0.82
1.3
1.4
—
—
—
0
0
6
32
1.88
0.82
1.3
1.2
12.8
29.7
nmol/l
—
6
25
26
189
1.38
0.81
2.5
3.3
56.9
58.2
%
0.21
26
189
11
66
1.67
0.79
1.1
1.0
—
—
—
0
0
41
322
1.28
0.78
3.2
4.6
—
—
—
0
0
18
124
1.46
0.75
1.1
1.0
—
—
—
0
0
141
1256
1.14
0.74
5.3
5.1
2.5
3.5
ug/l
0.67
123
1093
5
25
2.00
0.72
1.2
1.1
—
—
—
0
0
7
39
1.80
0.72
1.4
1.2
—
—
—
0
0
10
60
1.67
0.72
2.0
2.1
—
—
—
0
0
11
68
1.62
0.72
1.2
1.1
—
—
—
0
0
5
26
1.93
0.70
1.0
1.1
—
—
—
0
0
10
61
1.65
0.68
1.3
1.2
—
—
—
0
0
29
222
1.31
0.68
2.2
2.2
—
—
—
0
0
5
27
1.86
0.68
3.8
2.3
—
—
—
0
0
7
42
1.67
0.68
1.1
1.5
—
—
—
0
0
87
755
1.16
0.66
5.9
4.1
—
—
—
0
0
7
44
1.59
0.65
1.3
1.2
—
—
—
0
0
18
129
1.40
0.63
1.4
1.2
3.3
2.3
u/ml
—
9
54
14
96
1.46
0.61
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
28.0
33.3
73.4
112.0
ug/l
—
5
24
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
4.6
—
87.2
—
0
13
8
52
1.54
0.59
4.9
1.3
—
66.3
—
0
7
19
140
1.36
0.58
1.2
1.1
—
—
—
0
0
311
2933
1.08
0.57
3.4
2.7
—
—
—
0
0
20
150
1.34
0.56
1.2
1.5
—
—
—
0
0
29
230
1.27
0.55
3.1
1.5
—
—
—
0
0
31
248
1.26
0.55
3.1
1.5
—
—
—
0
0
6
37
1.62
0.55
1.3
1.4
138.0
149.1
nmol/l
—
6
37
31
249
1.25
0.54
3.1
1.5
—
—
—
0
0
71
621
1.15
0.52
1.4
1.2
—
—
—
0
0
31
251
1.24
0.51
3.1
1.5
—
—
—
0
0
7
107
0.65
0.48
2.3
3.4
—
—
—
0
0
14
102
1.38
0.47
1.0
1.3
—
35.3
—
0
6
19
147
1.30
0.45
1.1
1.1
2.4
7.2
u/ml
1.46
13
84
30
247
1.22
0.44
1.8
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
5
34
1.47
0.40
1.0
1.0
—
—
—
0
0
18
141
1.28
0.40
1.4
1.3
—
—
—
0
0
12
88
1.37
0.40
2.0
2.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
40
344
1.17
0.39
1.4
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
3.3
—
—
—
0
0
5
36
1.39
0.38
2.0
1.7
25.0
30.2
umol/l
—
5
36
823
8361
0.94
0.37
23.2
15.2
36.8
38.6
%
3.56
526
5885
30
253
1.19
0.37
2.8
3.9
3.9
3.8
mmol/l
0.10
23
234
10
72
1.39
0.37
1.2
1.4
—
—
—
0
0
11
145
0.76
0.34
2.4
1.8
—
—
—
0
0
6
46
1.31
0.33
1.2
1.2
—
2.2
—
0
16
34
294
1.16
0.32
1.3
1.2
—
—
—
0
0
11
83
1.33
0.32
1.5
1.3
—
—
—
0
0
12
92
1.31
0.32
1.4
1.2
—
—
—
0
0
7
52
1.35
0.31
1.3
1.1
—
—
—
0
0
8
64
1.25
0.27
1.0
1.3
—
—
—
0
0
102
957
1.07
0.25
1.7
1.8
—
—
—
0
0
9
73
1.23
0.25
1.2
1.1
—
—
—
0
0
20
170
1.18
0.24
1.2
1.1
0.1
1.7
u/ml
—
10
80
22
189
1.17
0.24
1.3
1.2
—
—
—
0
0
17
143
1.19
0.23
1.1
1.1
0.3
2.3
u/ml
—
10
74
29
257
1.13
0.22
1.3
1.2
—
—
—
0
0
32
286
1.12
0.22
3.5
3.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
7.5
—
0
5
0
11
0.00
0.21
0.0
1.4
—
49.9
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
10
80
1.25
0.20
2.4
2.8
—
—
—
0
0
769
7606
1.03
0.20
29.4
16.9
14.0
13.7
%
4.79
761
7436
7
63
1.11
0.17
1.0
1.1
—
9.6
—
0
15
5
66
0.76
0.17
4.2
3.9
12.6
10.5
%
—
5
66
226
2200
1.03
0.16
4.4
3.9
—
—
—
0
0
13
151
0.86
0.15
1.3
1.2
—
—
—
0
0
31
284
1.09
0.15
1.3
1.3
—
—
—
0
0
7
88
0.79
0.14
1.3
1.1
—
—
—
0
0
28
304
0.92
0.13
11.6
9.0
—
—
—
0
0
81
842
0.96
0.11
1.6
1.6
—
—
—
0
0
5
46
1.09
0.09
2.0
2.0
—
—
—
0
0
5
60
0.83
0.08
1.4
1.3
—
—
—
0
0
8
78
1.03
0.07
1.5
1.2
6.4
7.1
mmol/l
—
8
72
37
353
1.05
0.07
2.8
2.8
200.6
1022.3
u/ml
0.95
31
308
14
129
1.09
0.05
1.2
1.1
—
—
—
0
0
14
129
1.09
0.05
1.2
1.1
—
—
—
0
0
11
102
1.08
0.03
1.1
1.0
—
—
—
0
0
73
721
1.01
0.01
2.8
3.0
0.6
0.8
ug/l
2.70
53
473
86
852
1.01
0.01
1.4
1.4
—
—
—
0
0
13
126
1.03
0.00
1.2
1.2
—
—
—
0
0
15
149
1.01
0.00
2.9
2.8
58.4
60.6
%
0.18
15
149
246
2462
1.00
0.00
1.5
1.4
—
—
—
0
0
11
113
0.97
0.00
1.2
1.1
—
—
—
0
0
30
305
0.98
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
5
56
0.89
0.00
2.8
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
5.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.2
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
7.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_CONGEIOD and mortality.

Females

Parameter HR [95% CI] p-value
E4_CONGEIOD 1.653 [1.47, 1.86] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 2652 out of 8009 females with E4_CONGEIOD died.

Males

Parameter HR [95% CI] p-value
E4_CONGEIOD 2.094 [1.67, 2.62] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 700 out of 1891 males with E4_CONGEIOD died.

Mortality risk

Mortality risk for people of age

years, who have E4_CONGEIOD.

N-year risk Females Males
1 0.098% 0.386%
5 0.745% 2.472%
10 1.882% 5.762%
15 3.749% 10.868%
20 6.505% 17.926%

Relationships between endpoints

↥

Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data