testicular disease: A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1175 |
4. Check minimum number of eventsNone |
1175 |
5. Include endpointsNone |
1175 |
6. Filter based on genotype QC (FinnGen only) |
1175 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E29
- Name in latin
- Hypofunctio testium
Similar endpoints
↥List of similar endpoints to
Testicular hypofunction
based on the number of shared cases.
Similar with more cases:
- Testicular dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4793 | - | 4793 |
| Only index persons | 4698 | - | 4698 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | - | 0.13 |
| Only index persons | 0.18 | - | 0.18 |
| Median age at first event (years) | |||
| Whole population | - | - | 48.75 |
| Only index persons | - | - | 48.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1175 | - | 1175 |
| Unadjusted period prevalence (%) | 0.52 | - | 0.52 |
| Median age at first event (years) | 51.77 | - | 51.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1039
- Matched controls
- 10390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
175.9
323.0
911
402
121
Kela drug reimbursment
Severe hypofunction of sexual glands
875.8
323.0
389
7
E29.1
ICD-10 Finland
Testicular hypofunction
1303.7
323.0
871
41
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
75.9
142.9
161
25
Y28
ICPC
Limited function/disability (Y)
74.5
84.0
95
14
A50
ICPC
General and Unspecified, Medication/prescr/renewal
13.7
75.1
134
111
A55
ICPC
General and Unspecified, Local injection/infiltration
18.5
53.8
84
49
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
50.4
48
*
G47.3
ICD-10 Finland
Sleep apnoea
2.8
48.1
409
1934
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
9.6
39.1
82
92
G03GA01
ATC
chorionic gonadotrophin; parenteral
39.5
39.1
49
13
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
37.8
37.1
47
13
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.3
34.9
446
2523
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
6.3
32.0
88
150
T99
ICPC
Endocr/metab/nutrit disease other
19.3
31.6
48
26
R5140
NOMESCO Finland
Monitoring the use of the aid
3.0
30.7
197
744
KFC00
NOMESCO Finland
Unilateral orchiectomy
13.6
29.9
52
40
G04CA01
ATC
alfuzosin; oral
2.8
29.0
220
919
N48.4
ICD-10 Finland
Impotence of organic origin
5.5
27.5
84
163
N06AX11
ATC
mirtazapine; oral
2.2
27.1
349
1923
M01AH05
ATC
etoricoxib; oral
2.0
25.9
651
4707
H03AA01
ATC
levothyroxine sodium; systemic
3.1
25.8
158
572
N02AX02
ATC
tramadol; systemic, rectal
2.0
25.5
463
2935
N06AB10
ATC
escitalopram; oral
2.5
24.8
234
1096
N03AX16
ATC
pregabalin; oral
2.4
24.5
256
1267
A02BC05
ATC
esomeprazole; systemic
2.0
23.5
402
2464
N05BA04
ATC
oxazepam; oral
2.3
22.5
240
1192
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
22.4
433
2770
N06AX12
ATC
bupropion; oral
3.5
21.9
109
339
A02BC02
ATC
pantoprazole; systemic
1.9
21.8
607
4419
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
21.7
505
3444
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
21.7
431
2775
E29.9
ICD-10 Finland
Testicular dysfunction, unspecified
51.1
21.2
25
5
N05AH04
ATC
quetiapine; oral
2.3
20.9
213
1033
J01DB01
ATC
cefalexin; oral
2.1
20.8
844
7002
N62
ICD-10 Finland
Hypertrophy of breast
10.1
20.7
41
42
R03AC02
ATC
salbutamol; inhalant
1.9
20.1
484
3311
N03AX12
ATC
gabapentin; oral
2.5
20.0
174
775
T55
ICPC
Metabolic, Local injection/infiltration
58.7
20.0
23
*
N05CF02
ATC
zolpidem; oral
2.4
19.9
197
936
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
19.8
170
749
Q98.0
ICD-10 Finland
Klinefelter syndrome karyotype 47,XXY
75.0
19.8
22
*
R53
ICD-10 Finland
Malaise and fatigue
2.5
19.6
177
803
J01MA02
ATC
ciprofloxacin; systemic
1.9
19.4
384
2442
N06AX21
ATC
duloxetine; oral
2.9
19.3
127
479
J01CA04
ATC
amoxicillin; systemic
2.0
19.3
806
6625
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
11.3
19.3
36
33
J01FA10
ATC
azithromycin; systemic
1.8
19.2
566
4122
N06AX16
ATC
venlafaxine; oral
2.5
19.1
169
759
M03BX02
ATC
tizanidine; oral
1.8
18.9
656
5031
N05CF01
ATC
zopiclone; oral
2.0
18.8
296
1725
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
18.7
186
886
N06AX26
ATC
vortioxetine; oral
3.5
18.5
89
269
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
18.2
287
1671
N46
ICD-10 Finland
Male infertility
4.9
17.9
59
126
-50
ICPC
Medication/prescr/renewal
4.6
17.7
62
141
D75.1
ICD-10 Finland
Secondary polycythaemia
12.7
17.7
31
25
N06AB04
ATC
citalopram; systemic
2.1
16.9
207
1082
R01AD09
ATC
mometasone; nasal
1.8
16.8
428
2930
M01AE02
ATC
naproxen; oral, rectal
1.7
16.5
543
4016
M03BC51
ATC
orphenadrine, combinations; systemic
1.9
16.5
285
1705
M54.5
ICD-10 Finland
Low back pain
1.9
16.4
324
2033
N02BE01
ATC
paracetamol; systemic, rectal
1.9
16.2
817
6882
M01AB05
ATC
diclofenac; systemic, rectal
1.7
16.0
695
5566
A02BC03
ATC
lansoprazole; oral
1.9
15.9
260
1518
XKD00
NOMESCO Finland
Uroflowmetry
2.1
15.9
196
1025
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
15.7
15
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
15.7
15
*
WX723
NOMESCO Finland
CPAP therapy
3.4
15.5
77
240
J01AA02
ATC
doxycycline; systemic
1.8
15.4
745
6123
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
16.3
15.3
24
15
R06AX27
ATC
desloratadine; oral
1.9
15.3
250
1459
H02AB06
ATC
prednisolone; systemic
1.7
15.2
412
2852
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
15.1
498
3648
T28
ICPC
Limited function/disability (T)
10.3
15.0
29
29
R01AD12
ATC
fluticasone furoate; nasal
1.9
14.9
282
1736
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.5
14.8
70
210
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.2
14.7
56
139
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
14.7
137
629
R06.0
ICD-10 Finland
Dyspnoea
2.0
14.7
208
1147
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
14.6
322
2079
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
14.5
100
388
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
14.5
274
1679
Q98.4
ICD-10 Finland
Klinefelter syndrome, unspecified
152.0
14.5
15
*
L02BA01
ATC
tamoxifen; oral
27.6
14.3
19
7
H02AB09
ATC
hydrocortisone; systemic
7.5
14.3
33
45
R01AD08
ATC
fluticasone; nasal
1.8
14.3
280
1740
ZXE00
NOMESCO Finland
One hour or less
1.8
14.2
346
2303
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.7
14.2
101
398
M54.4
ICD-10 Finland
Lumbago with sciatica
2.1
14.1
166
850
SPAT1262
SPAT
Handing over of treatment supplies
2.0
13.8
191
1045
N06AB03
ATC
fluoxetine; oral
2.5
13.8
114
489
L02BG04
ATC
letrozole; oral
13.8
13.8
23
17
SPAT1254
SPAT
Administration of medicine
2.4
13.7
127
580
N04BC05
ATC
pramipexole; oral
3.3
13.7
69
218
R51.80
ICD-10 Finland
Headache
2.3
13.5
126
578
Y50
ICPC
Male Genital, Medication/prescr/renewal
26.1
13.4
18
7
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.3
13.3
49
118
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
13.3
141
684
R06.5
ICD-10 Finland
Mouth breathing
2.2
13.3
137
660
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
13.2
253
1551
E66.00
ICD-10 Finland
Metabolic syndrome
2.9
13.2
84
309
L02BG03
ATC
anastrozole; oral
40.6
13.2
16
*
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
13.1
85
318
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
13.0
290
1867
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
13.0
209
1206
E0000UV
ATC
NA
1.7
12.9
331
2223
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
12.9
233
1399
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
12.7
500
3779
J02AC01
ATC
fluconazole; systemic
1.9
12.7
193
1090
J01FA06
ATC
roxithromycin; oral
1.7
12.5
355
2454
M79.6
ICD-10 Finland
Pain in limb
1.7
12.5
291
1896
E89.5
ICD-10 Finland
Postprocedural testicular hypofunction
131.5
12.5
13
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.1
12.3
158
835
A02BC01
ATC
omeprazole; systemic
1.8
12.2
233
1424
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.9
12.2
200
1160
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
16.1
12.2
19
12
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.4
12.1
108
484
T50
ICPC
Metabolic, Medication/prescr/renewal
18.3
12.1
18
10
S55
ICPC
Skin, Local injection/infiltration
27.0
12.1
16
6
UKC02
NOMESCO Finland
Cystoscopy
2.0
11.9
160
860
F51.0
ICD-10 Finland
Nonorganic insomnia
2.2
11.8
125
607
J01MA12
ATC
levofloxacin; systemic
1.9
11.8
176
986
C09CA06
ATC
candesartan; oral
1.9
11.8
200
1174
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
11.7
91
380
WX780
NOMESCO Finland
Remote monitoring CPAP
2.8
11.7
77
292
N40
ICD-10 Finland
Hyperplasia of prostate
1.8
11.6
232
1434
KFH50
NOMESCO Finland
Insertion of prosthetic replacement for testis
23.2
11.6
16
7
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
11.6
174
975
H02AB04
ATC
methylprednisolone; systemic
2.2
11.6
127
626
R06AE07
ATC
cetirizine; oral
1.6
11.5
365
2585
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
11.5
11
*
N05BA12
ATC
alprazolam; oral
2.3
11.5
108
497
N05CD07
ATC
temazepam; oral
2.3
11.4
105
475
AA1AD
NOMESCO Finland
CT of head and brain
1.8
11.3
208
1252
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
11.3
296
1987
R52.2
ICD-10 Finland
Other chronic pain
4.4
11.3
40
94
M01AC06
ATC
meloxicam; systemic, rectal
1.7
11.2
318
2181
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
11.2
245
1557
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.6
11.1
80
319
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.5
11.1
51
151
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
11.0
49
141
J05AB11
ATC
valaciclovir; oral
2.3
11.0
105
485
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
10.9
404
2968
C07AA05
ATC
propranolol; systemic
1.9
10.8
165
930
P01AB01
ATC
metronidazole; oral, rectal
1.7
10.8
279
1863
L03
ICPC
Low back symptom/complaint
1.8
10.8
192
1141
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
10.8
109
519
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.7
10.7
75
296
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.6
197
1189
M04AA01
ATC
allopurinol; systemic
2.1
10.4
123
627
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
10.3
54
177
C62.12
ICD-10 Finland
Malignant tumor of the descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
19.0
10.3
15
8
N06AB06
ATC
sertraline; oral
2.1
10.2
112
553
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.9
10.2
60
212
Y05
ICPC
Scrotum/testis sympt/compl other
5.5
10.2
29
54
WVA30
SPAT
NA
3.8
10.1
42
115
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
10.1
200
1229
127
Kela drug reimbursment
Transplant complication
5.2
10.0
30
59
E66.8
ICD-10 Finland
Other obesity
3.0
10.0
57
197
E29
ICD-10 Finland
Testicular dysfunction
40.5
10.0
12
*
A98
ICPC
Health maint/preventive medicine
2.3
9.9
987
9252
R01BA52
ATC
pseudoephedrine, combinations; oral
1.7
9.7
252
1673
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
9.7
217
1383
M48.0
ICD-10 Finland
Spinal stenosis
2.2
9.7
101
486
OAB72
NOMESCO Finland
Weight control and weight loss guidance
13.5
9.7
16
12
E22.1
ICD-10 Finland
Hyperprolactinaemia
55.5
9.7
11
*
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
9.7
145
811
N06BA04
ATC
methylphenidate; oral
4.1
9.6
36
90
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
9.5
93
435
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
9.5
158
914
N05BA01
ATC
diazepam; systemic, rectal
2.0
9.5
125
663
C07AB07
ATC
bisoprolol; oral
1.6
9.4
371
2738
H01AC01
ATC
somatropin; parenteral
100.9
9.4
10
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
9.4
9
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
9.4
9
*
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
+∞
9.4
9
*
2572A
ICD-9 Finland
Testicular dysfunction, Other testicular hypofunction
+∞
9.4
9
*
J01FA09
ATC
clarithromycin; systemic
1.6
9.4
276
1896
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
9.3
60
226
C10AA07
ATC
rosuvastatin; oral
1.7
9.3
222
1441
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
9.3
81
360
J05AB01
ATC
aciclovir; systemic
1.8
9.3
156
909
N06AA12
ATC
doxepin; systemic
2.9
9.2
54
191
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.2
211
1350
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.4
9.1
78
343
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
9.1
146
836
R06AX22
ATC
ebastine; oral
1.9
9.1
137
768
SPAT1310
SPAT
Counselling related to known health issue
1.6
9.1
247
1661
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
37.0
9.0
11
*
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.9
9.0
53
189
R50.9
ICD-10 Finland
Fever, unspecified
1.9
8.9
141
802
M02AA07
ATC
piroxicam; topical
1.6
8.9
290
2041
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
12.7
8.9
15
12
UDC00
NOMESCO Finland
Ear microscopy
2.4
8.8
73
316
J01FF01
ATC
clindamycin; systemic
1.6
8.8
257
1757
S50
ICPC
Skin, Medication/prescr/renewal
8.7
8.8
18
21
Y08
ICPC
Sexual function sympt/compl male
9.6
8.8
17
18
P06
ICPC
Sleep disturbance
2.1
8.8
95
467
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
8.7
257
1762
C62.19
ICD-10 Finland
Malignant tumor of the descending testicle, other or undetermined histology
50.4
8.7
10
*
N03AX09
ATC
lamotrigine; oral
2.7
8.7
58
221
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
8.7
153
906
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
8.7
299
2133
ZXD05
NOMESCO Finland
Urgent procedure
1.6
8.7
262
1808
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
8.5
202
1306
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
3.5
8.5
38
111
T29
ICPC
Endocr/metab/nutr sympt/compl other
5.0
8.5
26
53
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.3
8.5
77
349
J01AA04
ATC
lymecycline; systemic
1.9
8.5
118
642
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
8.4
97
489
G04CA02
ATC
tamsulosin; oral
1.6
8.4
245
1674
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
8.4
92
452
E23.05
ICD-10 Finland
Lack of TSH
90.7
8.4
9
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
8.4
361
2705
Z3231
NOMESCO Finland
Registered nurse
1.6
8.4
232
1563
A02BC04
ATC
rabeprazole; oral
2.3
8.4
78
359
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
8.3
8
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
8.3
8
*
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.6
8.3
234
1582
N06AX22
ATC
agomelatine; oral
4.1
8.3
31
78
Y99
ICPC
Genital disease male other
9.5
8.3
16
17
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.3
8.2
29
69
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.6
8.2
59
235
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
8.2
63
264
X58
ICD-10 Finland
Exposure to other specified factors
1.7
8.1
164
1011
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
8.1
125
705
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
8.0
217
1451
E29.8
ICD-10 Finland
Other testicular dysfunction
22.2
8.0
11
5
M25.5
ICD-10 Finland
Pain in joint
1.6
8.0
224
1513
C03CA01
ATC
furosemide; systemic
1.7
8.0
165
1025
R01AD01
ATC
beclometasone; nasal
1.8
8.0
135
787
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
8.0
369
2804
75210
ICD-8 Finland
Congenital anomalies of genital organs, Undescended testicle
4.3
7.9
28
67
N18.8
ICD-10 Finland
Other chronic renal failure
3.8
7.9
32
87
L17
ICPC
Foot/toe symptom/complaint
1.7
7.9
176
1117
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.4
7.9
66
286
F32.1
ICD-10 Finland
Moderate depressive episode
2.8
7.9
50
187
R02
ICPC
Shortness of breath/dyspnoea
2.1
7.8
84
412
Z01.2
ICD-10 Finland
Dental examination
1.5
7.8
353
2666
L03AA02
ATC
filgrastim; parenteral
4.1
7.8
29
73
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
7.7
133
779
H05BX01
ATC
cinacalcet; oral
45.3
7.7
9
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.3
7.6
70
317
R03BA08
ATC
ciclesonide; inhalant
2.3
7.6
68
306
L08
ICPC
Shoulder symptom/complaint
1.7
7.6
153
940
N41.1
ICD-10 Finland
Chronic prostatitis
2.7
7.6
49
186
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
25.2
7.6
10
*
R03BA05
ATC
fluticasone; inhalant
1.8
7.6
140
840
R03DC03
ATC
montelukast; oral
1.8
7.5
121
695
J01DA01
ATC
[U] cefalexin; systemic
1.4
7.5
555
4614
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
7.5
223
1527
P76
ICPC
Depressive disorder
2.5
7.5
58
242
SPAT1312
SPAT
General health counselling
1.6
7.5
239
1664
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
7.5
247
1736
M01AX17
ATC
nimesulide; oral
1.7
7.5
181
1173
SPAT1301
SPAT
No procedures
1.6
7.4
228
1573
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
80.6
7.4
8
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
7.4
153
946
C08CA01
ATC
amlodipine; oral
1.5
7.3
286
2086
N06AB05
ATC
paroxetine; oral
2.3
7.3
66
299
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.3
671
5796
G03GA05
ATC
follitropin alfa; parenteral
+∞
7.3
7
*
G03GA02
ATC
human menopausal gonadotrophin; parenteral
+∞
7.3
7
*
A02BA02
ATC
ranitidine; systemic
1.7
7.3
142
864
SPAT1263
SPAT
Sampling
1.5
7.2
333
2515
M54.2
ICD-10 Finland
Cervicalgia
2.3
7.2
63
282
KFA00
NOMESCO Finland
Exploration of testis
8.0
7.1
15
19
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
7.1
170
1100
Z01.9
ICD-10 Finland
Special examination, unspecified
2.7
7.1
46
176
R05FA02
ATC
opium derivatives and expectorants; systemic
1.5
7.1
299
2218
7525A
ICD-9 Finland
Congenital anomalies of genital organs, Undescended testicle[RETENTIO TESTIS (CRYPTORCHISMUS)]
8.8
7.1
14
16
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
7.1
62
279
SPAT1325
SPAT
Vaccination
1.6
7.0
221
1532
WX110
NOMESCO Finland
Local anesthesy
1.4
7.0
654
5644
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
7.0
7.0
16
23
WX320
NOMESCO Finland
Spinalanesthesy
1.6
7.0
169
1095
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.8
7.0
43
160
R06AX13
ATC
loratadine; oral
1.8
7.0
116
671
J01EA01
ATC
trimethoprim; systemic
2.1
7.0
80
405
H02.3
ICD-10 Finland
Blepharochalasis
3.1
6.9
36
120
A04
ICPC
Weakness/tiredness general
2.1
6.9
75
370
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
6.9
171
1114
N06AA09
ATC
amitriptyline; systemic
2.2
6.9
70
336
T90
ICPC
Diabetes non-insulin dependent
1.6
6.9
201
1368
M54.1
ICD-10 Finland
Radiculopathy
2.9
6.9
40
143
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.9
6.8
39
136
M05BA04
ATC
alendronic acid; oral
3.2
6.8
34
110
C08CA02
ATC
felodipine; oral
2.2
6.8
65
303
R35
ICD-10 Finland
Polyuria
2.3
6.8
62
281
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
40.3
6.8
8
*
SPAT1094
SPAT
Continuous Positive Airway Pressure
4.3
6.7
23
54
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.7
446
3606
L01
ICPC
Neck symptom/complaint
2.0
6.7
86
452
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
6.7
124
741
L04AA06
ATC
mycophenolic acid; systemic
4.0
6.7
25
64
R60.0
ICD-10 Finland
Localized oedema
2.1
6.7
76
384
A10BA02
ATC
metformin; oral
1.5
6.7
229
1621
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.6
524
4365
N06AX05
ATC
trazodone; oral
3.8
6.6
26
70
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.2
6.6
32
102
DHB50
NOMESCO Finland
Turbinoplasty
2.7
6.6
42
158
M79.1
ICD-10 Finland
Myalgia
1.9
6.6
93
511
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
6.5
75
381
Y29
ICPC
Genital symptom/complaint male other
5.1
6.5
19
38
R03AC03
ATC
terbutaline; inhalant
1.8
6.5
107
619
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.5
6.5
47
193
J01MA14
ATC
moxifloxacin; systemic
2.0
6.5
80
416
Y55
ICPC
Male Genital, Local injection/infiltration
70.3
6.4
7
*
D07AC13
ATC
mometasone; topical
1.5
6.4
238
1712
ZXA05
NOMESCO Finland
Left side
1.6
6.4
192
1313
205
Kela drug reimbursment
Chronic hypertension
1.6
6.4
189
1287
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.9
6.4
19
39
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
6.4
60
280
SBB10
NOMESCO Finland
Teeth copy
2.3
6.4
57
259
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
6.4
82
436
M01AE01
ATC
ibuprofen; systemic, rectal
1.6
6.3
902
8369
L28
ICPC
Limited function/disability (L)
1.9
6.3
93
516
N02AA05
ATC
oxycodone; systemic
1.8
6.3
106
617
C08CA13
ATC
lercanidipine; oral
1.9
6.3
95
533
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
6.3
100
568
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.7
6.3
41
158
E23.03
ICD-10 Finland
Lack of ACTH
+∞
6.3
6
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
6.2
44
176
Y10
ICPC
Infertility/subfertility male
26.8
6.2
8
*
C62.1
ICD-10 Finland
Malignant neoplasm: Descended testis
26.8
6.2
8
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
26.8
6.2
8
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.6
6.2
44
177
M54
ICD-10 Finland
Dorsalgia
1.8
6.2
96
545
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
6.2
90
500
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.1
6.2
63
304
JN4BD
NOMESCO Finland
Extensive body CT
1.9
6.2
86
470
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.4
6.2
27
80
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.0
6.1
72
369
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.1
592
5080
M01AC01
ATC
piroxicam; systemic, rectal
1.8
6.1
106
624
R06AX18
ATC
acrivastine; oral
3.5
6.1
26
75
HMAK
NOMESCO Finland
NA
1.8
6.1
104
609
A99
ICPC
Disease/condition unspecnature/site
2.2
6.1
60
284
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
6.1
280
2104
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.6
6.1
190
1310
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
6.1
133
837
C02AC05
ATC
moxonidine; oral
2.7
6.1
39
147
Mortality – FinRegistry
↥Association
Association between endpoint E4_TESTICHYPO and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_TESTICHYPO | 1.58 [1.3, 1.91] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 243 out of 2410 males with E4_TESTICHYPO died.
Mortality risk
Mortality risk for people of age
years, who have E4_TESTICHYPO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.265% |
| 5 | No data | 1.557% |
| 10 | No data | 4.102% |
| 15 | No data | 7.786% |
| 20 | No data | 13.192% |
Relationships between endpoints
↥Index endpoint: E4_TESTICHYPO – Testicular hypofunction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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