Other and unspecified mononeuropathies of upper limb

G6_MONONPOTHUS

mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G56.8, G56.9
  • Hospital discharge: ICD-9 354[8-9]
  • Cause of death: ICD-10 G56.8, G56.9
  • Cause of death: ICD-9 354[8-9]

2 out of 7 registries used, show all original rules.

1154

4. Check minimum number of events

None

1154

5. Include endpoints

None

1154

6. Filter based on genotype QC (FinnGen only)

1154

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8274 4003 4241
Only index persons 7776 3828 3948
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.12
Only index persons 0.15 0.14 0.15
Median age at first event (years)
Whole population 47.79 49.30 46.34
Only index persons 47.14 48.74 45.59

-FinnGen-

Key figures

All Female Male
Number of individuals 1154 632 522
Unadjusted period prevalence (%) 0.22 0.22 0.23
Median age at first event (years) 48.24 46.83 49.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1012
Matched controls
10119
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G56.8
ICD-10 Finland
Other mononeuropathies of upper limb
2003.9
323.0
449
*
G56.9
ICD-10 Finland
Mononeuropathy of upper limb, unspecified
2003.9
323.0
449
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
45.5
251.0
310
97
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
369.7
211.1
206
7
ACC51
NOMESCO Finland
Release of median nerve
396.8
138.3
136
*
3548X
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Other mononeuritis of upper limb
+∞
126.8
119
*
G56.2
ICD-10 Finland
Lesion of ulnar nerve
93.4
92.0
101
12
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
82.2
74.4
83
11
G54.0
ICD-10 Finland
Brachial plexus disorders
42.5
69.2
86
22
N03AX16
ATC
pregabalin; oral
3.5
57.2
328
1209
N03AX12
ATC
gabapentin; oral
4.1
51.5
232
691
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.1
45.8
317
1306
N02AX02
ATC
tramadol; systemic, rectal
2.6
45.3
501
2754
ACC53
NOMESCO Finland
Release of ulnar nerve
434.9
42.5
42
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
39.7
532
3165
XA402
NOMESCO Finland
ENMG
15.3
39.5
66
46
M79.6
ICD-10 Finland
Pain in limb
2.5
38.1
411
2166
M25.5
ICD-10 Finland
Pain in joint
2.6
35.1
340
1672
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.8
34.1
159
475
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.7
30.7
92
175
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.1
30.1
187
691
M01AH05
ATC
etoricoxib; oral
2.2
30.1
644
4516
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.2
28.6
114
294
N06AX21
ATC
duloxetine; oral
3.3
27.1
146
486
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
25.6
137
453
M54.5
ICD-10 Finland
Low back pain
2.2
25.3
349
1976
N02BE01
ATC
paracetamol; systemic, rectal
2.4
24.8
866
7181
M03BX02
ATC
tizanidine; oral
2.0
24.1
654
4827
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.3
23.1
89
222
G56.4
ICD-10 Finland
Causalgia
+∞
23.0
22
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
23.0
397
2446
M01AB05
ATC
diclofenac; systemic, rectal
2.0
22.6
690
5258
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
4.7
22.5
78
175
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
22.3
369
2227
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.5
22.0
107
327
X58
ICD-10 Finland
Exposure to other specified factors
2.6
20.5
171
744
L08
ICPC
Shoulder symptom/complaint
2.3
19.9
204
989
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
19.9
228
1165
5851
FHL
Rib resection due to local change or compression
+∞
19.9
19
*
M02AA07
ATC
piroxicam; topical
1.9
19.6
370
2324
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.2
19.5
109
368
M54.4
ICD-10 Finland
Lumbago with sciatica
2.5
19.3
172
775
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.5
19.0
91
275
G56.3
ICD-10 Finland
Lesion of radial nerve
56.1
19.0
22
*
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
101.9
18.6
20
*
ZXA05
NOMESCO Finland
Left side
2.1
18.3
253
1400
M03BC01
ATC
orphenadrine (citrate); systemic
2.0
18.1
266
1508
M01AE02
ATC
naproxen; oral, rectal
1.8
18.0
571
4240
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
7.7
17.8
41
55
M01AX17
ATC
nimesulide; oral
2.1
17.8
241
1321
R20.2
ICD-10 Finland
Paraesthesia of skin
3.3
17.5
93
304
M77.1
ICD-10 Finland
Lateral epicondylitis
3.0
17.2
102
360
R03AC02
ATC
salbutamol; inhalant
1.8
16.7
519
3786
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
16.7
16
*
ZXA00
NOMESCO Finland
Right side
2.0
16.6
265
1544
G58.8
ICD-10 Finland
Other specified mononeuropathies
91.6
16.6
18
*
N06AA09
ATC
amitriptyline; systemic
2.8
16.5
114
442
G57.6
ICD-10 Finland
Lesion of plantar nerve
12.4
16.4
29
24
R51.80
ICD-10 Finland
Headache
2.3
16.4
163
772
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.6
16.2
74
215
G44.2
ICD-10 Finland
Tension-type headache
2.4
16.1
148
675
A02BC02
ATC
pantoprazole; systemic
1.7
15.7
626
4889
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
15.6
369
2453
M01AH01
ATC
celecoxib; oral (coxibs)
2.1
15.3
186
964
S18
ICPC
Laceration/cut
1.8
15.2
391
2665
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.8
15.2
101
385
Z50.1
ICD-10 Finland
Other physical therapy
3.5
14.8
70
210
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.7
14.8
478
3483
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
14.5
255
1531
J01DB01
ATC
cefalexin; oral
1.8
14.4
802
6838
M48.0
ICD-10 Finland
Spinal stenosis
2.6
14.2
111
462
M89.0
ICD-10 Finland
Algoneurodystrophy
14.7
14.1
23
16
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
5.7
14.0
40
73
M01AC06
ATC
meloxicam; systemic, rectal
1.7
13.9
344
2303
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
5.6
13.9
40
74
3530A
ICD-9 Finland
Nerve root and plexus disorders, Brachial plexus lesions
+∞
13.6
13
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
13.6
170
892
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.6
13.5
47
107
G54.9
ICD-10 Finland
Nerve root and plexus disorder, unspecified
34.5
13.5
17
5
J01DA01
ATC
[U] cefalexin; systemic
1.7
13.5
599
4721
L03
ICPC
Low back symptom/complaint
1.9
13.4
226
1329
ZXH06
SPAT
NA
5.4
13.3
39
74
M47.9
ICD-10 Finland
Spondylosis, unspecified
5.6
13.2
38
70
M54.2
ICD-10 Finland
Cervicalgia
3.0
13.2
77
270
H02AB06
ATC
prednisolone; systemic
1.7
13.2
437
3173
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
12.4
13.1
23
19
M54.1
ICD-10 Finland
Radiculopathy
4.0
13.1
52
135
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
13.1
79
282
J01AA02
ATC
doxycycline; systemic
1.7
12.7
756
6406
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
5.0
12.6
40
83
L12
ICPC
Hand/finger symptom/complaint
2.2
12.6
138
680
3549X
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Mononeuritis of upper limb, unspecified
+∞
12.5
12
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
24.6
12.5
17
7
SPAT1153
SPAT
Removal of sutures
1.7
12.5
289
1884
A02BC01
ATC
omeprazole; systemic
1.8
12.3
260
1647
R52.9
ICD-10 Finland
Pain, unspecified
2.7
12.2
84
328
AA1AD
NOMESCO Finland
CT of head and brain
1.9
12.1
209
1236
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.4
12.1
43
101
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
7.4
12.0
28
39
L01
ICPC
Neck symptom/complaint
2.2
12.0
136
681
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.6
11.8
85
339
R52.2
ICD-10 Finland
Other chronic pain
4.3
11.8
43
103
N03AE01
ATC
clonazepam; systemic
3.0
11.7
68
238
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
11.7
209
1250
J01FF01
ATC
clindamycin; systemic
1.7
11.7
265
1709
M01AH02
ATC
rofecoxib; oral
2.2
11.7
130
647
G56.1
ICD-10 Finland
Other lesions of median nerve
65.7
11.6
13
*
A02BC03
ATC
lansoprazole; oral
1.7
11.6
277
1815
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
11.6
264
1706
R42
ICD-10 Finland
Dizziness and giddiness
1.9
11.6
193
1126
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
5.1
11.5
35
70
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.1
11.3
35
71
M50.3
ICD-10 Finland
Other cervical disc degeneration
5.2
11.3
34
67
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
11.3
673
5597
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
11.3
109
507
M54.3
ICD-10 Finland
Sciatica
3.0
11.2
65
228
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.9
11.0
44
116
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.6
11.0
503
3908
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
10.9
111
528
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
3.0
10.9
63
220
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
5.0
10.9
34
70
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.6
10.9
82
336
C07AB07
ATC
bisoprolol; oral
1.6
10.7
400
2945
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.6
10.7
395
2901
M79.1
ICD-10 Finland
Myalgia
2.1
10.7
121
607
N03AF02
ATC
oxcarbazepine; oral
4.3
10.6
38
90
M03BC51
ATC
orphenadrine, combinations; systemic
1.7
10.5
277
1857
3542A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Lesion of ulnar nerve
+∞
10.4
10
*
N06AB04
ATC
citalopram; systemic
1.8
10.4
214
1335
M01AE01
ATC
ibuprofen; systemic, rectal
1.9
10.4
892
8089
L16
ICPC
Ankle symptom/complaint
2.4
10.3
87
377
J01CA04
ATC
amoxicillin; systemic
1.6
10.3
774
6732
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
10.2
198
1211
SPAT1301
SPAT
No procedures
1.7
10.2
275
1854
A02BC05
ATC
esomeprazole; systemic
1.6
10.1
375
2746
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
10.1
242
1580
G50.1
ICD-10 Finland
Atypical facial pain
11.4
10.1
18
16
WX120
NOMESCO Finland
Intravenous local anesthesy of arm
11.4
10.1
18
16
R06.0
ICD-10 Finland
Dyspnoea
1.8
10.0
212
1330
M77.0
ICD-10 Finland
Medial epicondylitis
4.8
10.0
32
68
WX110
NOMESCO Finland
Local anesthesy
1.5
10.0
643
5357
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
5.1
9.9
30
60
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
9.9
118
605
L11
ICPC
Wrist symptom/complaint
2.6
9.8
72
292
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.3
9.6
91
421
S40.0
ICD-10 Finland
Contusion of shoulder and upper arm
3.4
9.5
44
132
K02.1
ICD-10 Finland
Caries of dentine
1.5
9.4
533
4284
M01AB55
ATC
diclofenac, combinations; oral
2.6
9.4
67
267
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.8
9.4
170
1013
ACC52
NOMESCO Finland
Release of radial nerve
+∞
9.4
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
9.4
373
2770
M79.7
ICD-10 Finland
Fibromyalgia
3.8
9.3
38
103
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
9.2
86
394
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
9.1
173
1048
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.6
9.1
246
1654
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
11.6
9.1
16
14
W22
ICD-10 Finland
Striking against or struck by other object(s)
2.4
9.0
74
318
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
5.1
9.0
27
54
N06AX11
ATC
mirtazapine; oral
1.6
9.0
286
2006
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.7
9.0
29
63
G51.0
ICD-10 Finland
Bell palsy
24.2
8.9
12
5
NCL99
NOMESCO Finland
Other operation on muscle or tendon of elbow or forearm
12.7
8.9
15
12
N05AH04
ATC
quetiapine; oral
1.8
8.8
157
930
WX204
NOMESCO Finland
Axillary plexus blockaced
3.7
8.8
37
103
M65.3
ICD-10 Finland
Trigger finger
3.2
8.8
44
141
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
8.7
174
1069
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
50.4
8.7
10
*
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
50.4
8.7
10
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
8.6
135
768
N01
ICPC
Headache
2.1
8.6
94
465
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
4.3
8.5
30
71
N06AA10
ATC
nortriptyline; systemic
4.3
8.5
30
71
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
8.5
141
815
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
6.5
8.5
21
33
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
3.2
8.5
43
139
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.6
8.5
59
234
NBG10
NOMESCO Finland
Acromioplastia
4.0
8.4
32
82
R53
ICD-10 Finland
Malaise and fatigue
1.7
8.4
174
1082
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
8.3
163
996
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.3
238
1619
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
5.3
8.3
24
46
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
8.3
407
3141
R01AD09
ATC
mometasone; nasal
1.5
8.3
416
3226
T92.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of upper limb
9.5
8.3
16
17
M47.82
ICD-10 Finland
Other spondylosis, cervical region
3.3
8.3
40
125
WZA90
NOMESCO Finland
Other doctors statement
1.7
8.2
204
1339
S06.0
ICD-10 Finland
Concussion
2.1
8.2
95
482
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.2
8.1
81
383
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
8.1
348
2605
2401
FHL
Nerve exploration (includes biopsy and removal of local change)
33.6
8.1
10
*
7233A
ICD-9 Finland
Other disorders of cervical region, Cervicobrachial syndrome (diffuse)
33.6
8.1
10
*
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
11.8
8.1
14
12
L30.3
ICD-10 Finland
Infective dermatitis
3.3
8.1
39
122
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
8.1
266
1872
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.5
8.1
534
4380
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
8.0
599
5027
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.6
8.0
58
232
R03DC03
ATC
montelukast; oral
1.8
8.0
144
856
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
8.0
137
801
J01FA06
ATC
roxithromycin; oral
1.5
8.0
360
2723
SPAT1263
SPAT
Sampling
1.5
8.0
367
2790
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.0
148
888
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
7.9
72
325
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
5.0
7.9
24
49
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
5.0
7.9
24
49
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.8
383
2943
7261X
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Rotator cuff syndrome of shoulder and allied disorders[MUU TAI TARKEMMIN MÄÄRITTELEM KIERTÄJÄKALVOSINSDR]
8.5
7.8
16
19
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
7.7
95
493
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
7.7
111
614
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.6
337
2534
EBA00
NOMESCO Finland
Extraction of tooth
1.5
7.6
290
2109
T92.4
ICD-10 Finland
Sequelae of injury of nerve of upper limb
18.5
7.6
11
6
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.8
7.6
30
80
G58.9
ICD-10 Finland
Mononeuropathy, unspecified
25.2
7.6
10
*
H02AB04
ATC
methylprednisolone; systemic
1.8
7.6
133
783
M01AC01
ATC
piroxicam; systemic, rectal
1.9
7.6
119
675
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
7.6
465
3739
E0000UV
ATC
NA
1.5
7.5
349
2647
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
7.5
83
411
SGA01
NOMESCO Finland
Tooth opening as first aid
1.7
7.4
147
902
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
7.4
74
352
J46
ICD-10 Finland
Status asthmaticus
4.1
7.4
27
67
M65.4
ICD-10 Finland
Radial styloid tenosynovitis [de Quervain]
3.8
7.4
29
77
M70.6
ICD-10 Finland
Trochanteric bursitis
1.9
7.4
101
546
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
7.4
354
2702
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
7.4
63
277
UJF32
NOMESCO Finland
Coloscopy
1.6
7.4
221
1516
M01AX05
ATC
glucosamine; oral
1.7
7.3
157
985
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
7.3
255
1815
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
7.3
468
3785
N03AX09
ATC
lamotrigine; oral
2.6
7.3
50
196
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.2
177
1154
L92
ICPC
Shoulder syndrome
4.0
7.2
27
69
J01FA10
ATC
azithromycin; systemic
1.4
7.2
539
4485
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.5
7.2
54
224
TAB00
NOMESCO Finland
Lumbar puncture
2.6
7.2
48
187
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.1
7.2
75
365
R03BA05
ATC
fluticasone; inhalant
1.7
7.2
157
990
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
7.2
38
128
TAD02
NOMESCO Finland
Sympathetic block of ganglion stellatum
30.2
7.2
9
*
A02BA02
ATC
ranitidine; systemic
1.7
7.1
169
1091
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
7.1
105
585
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
7.1
243
1722
WZC00
SPAT
NA
2.8
7.1
43
158
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
7.1
217
1496
C07AA05
ATC
propranolol; systemic
1.6
7.1
174
1132
SPAT1310
SPAT
Counselling related to known health issue
1.5
7.0
269
1953
A46
ICD-10 Finland
Erysipelas
1.8
7.0
111
633
M03BX01
ATC
baclofen; systemic
4.5
7.0
23
52
M13.9
ICD-10 Finland
Arthritis, unspecified
2.2
6.9
68
320
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.2
6.9
68
320
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
3.1
6.9
36
120
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
6.9
88
466
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.5
6.9
54
227
A01
ICPC
Pain general/multiple sites
2.2
6.9
66
310
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
2.5
6.9
51
209
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
6.9
115
667
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.5
6.8
51
210
WX200
NOMESCO Finland
Interscalenous plexus blockade
4.0
6.8
25
63
WX290
NOMESCO Finland
Other blockade of nerve
1.4
6.8
399
3158
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.5
6.7
29
84
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
6.7
86
452
WW200
SPAT
NA
1.9
6.7
105
595
R06AE07
ATC
cetirizine; oral
1.4
6.7
392
3102
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
3.0
6.6
36
124
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.0
6.6
81
420
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.6
6.6
159
1030
J01FA09
ATC
clarithromycin; systemic
1.5
6.5
281
2089
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.0
6.5
34
114
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.5
503
4178
G47.3
ICD-10 Finland
Sleep apnoea
1.6
6.5
184
1244
N03AF01
ATC
carbamazepine; oral, rectal
2.5
6.5
46
186
G57.9
ICD-10 Finland
Mononeuropathy of lower limb, unspecified
70.3
6.4
7
*
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
2.6
6.4
45
179
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.4
334
2580
M22.4
ICD-10 Finland
Chondromalacia patellae
2.9
6.4
37
132
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.4
212
1488
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
6.4
160
1048
S22.3
ICD-10 Finland
Fracture of rib
2.3
6.4
59
270
M24.2
ICD-10 Finland
Disorder of ligament
4.6
6.3
20
44
L86
ICPC
Back syndrome with radiating pain
2.4
6.3
48
202
2404
FHL
Nerve dissection (obturator 9364, Morton 9273, nerve tympanicus 4162)
+∞
6.3
6
*
35708
ICD-8 Finland
Other diseases of peripheral nerves except autonomic, Alterius nervi
+∞
6.3
6
*
R60.0
ICD-10 Finland
Localized oedema
1.9
6.2
86
466
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.6
6.2
191
1314
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
2.7
6.2
38
142
N02AA05
ATC
oxycodone; systemic
1.8
6.1
109
645
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
6.1
175
1183
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
4.3
6.1
21
50
M76.0
ICD-10 Finland
Gluteal tendinitis
4.1
6.1
22
55
S14.3
ICD-10 Finland
Injury of brachial plexus
12.6
6.1
10
8
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
12.6
6.1
10
8
R07.3
ICD-10 Finland
Other chest pain
1.9
6.1
83
448
SPAT1240
SPAT
Therapeutic discussion
1.8
6.0
94
532
G50.0
ICD-10 Finland
Trigeminal neuralgia
10.1
6.0
11
11
M75.8
ICD-10 Finland
Other shoulder lesions
2.9
6.0
33
115

Mortality – FinRegistry

Association

Association between endpoint G6_MONONPOTHUS and mortality.

Females

Parameter HR [95% CI] p-value
G6_MONONPOTHUS 1.214 [1.06, 1.39] 0.004
Birth year 0.999 [0.99, 1.01] 0.8

During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 3043 females with G6_MONONPOTHUS died.

Males

Parameter HR [95% CI] p-value
G6_MONONPOTHUS 1.422 [1.24, 1.63] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 468 out of 3225 males with G6_MONONPOTHUS died.

Mortality risk

Mortality risk for people of age

years, who have G6_MONONPOTHUS.

N-year risk Females Males
1 0.087% 0.276%
5 0.669% 1.607%
10 1.97% 3.865%
15 4.024% 7.496%
20 7.219% 12.516%

Relationships between endpoints

Index endpoint: G6_MONONPOTHUS – Other and unspecified mononeuropathies of upper limb

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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