No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1257 |
4. Check minimum number of eventsNone |
1257 |
5. Include endpointsNone |
1257 |
6. Filter based on genotype QC (FinnGen only) |
1257 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H50
- Name in latin
- Strabismus verticalis
Similar endpoints
↥List of similar endpoints to
Vertical strabismus
based on the number of shared cases.
Similar with more cases:
- Other strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9645 | 5200 | 4422 |
| Only index persons | 8778 | 4806 | 3972 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.12 |
| Only index persons | 0.17 | 0.18 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 28.68 | 28.55 | 28.72 |
| Only index persons | 30.56 | 30.52 | 30.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1257 | 758 | 499 |
| Unadjusted period prevalence (%) | 0.24 | 0.26 | 0.22 |
| Median age at first event (years) | 47.02 | 42.89 | 53.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1143
- Matched controls
- 11430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H50.2
ICD-10 Finland
Vertical strabismus
4503599627370496.0
323.0
902
*
H53.2
ICD-10 Finland
Diplopia
41.2
202.3
255
79
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
181.2
169
*
37302
ICD-8 Finland
Strabismus, Concomitans sursum sive deorsum vergens
+∞
174.6
163
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
1463.8
136.3
130
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
135.1
127
*
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
1325.4
124.4
119
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
121.0
114
*
3783A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Other and unspecified heterotropia
+∞
115.6
109
*
3503
FHL
Single muscle retroposition
+∞
101.6
96
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.0
90.4
282
594
H50.52
ICD-10 Finland
Exophoria
443.9
84.2
83
*
H50.31
ICD-10 Finland
Intermittent exotropia
+∞
72.7
69
*
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
71.6
68
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
64.2
61
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
60.7
63.5
74
13
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
63.1
60
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
47.8
273
969
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
47.2
45
*
H50.8
ICD-10 Finland
Other specified strabismus
+∞
41.9
40
*
H50.30
ICD-10 Finland
Intermittent esotropy
+∞
40.9
39
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
7.8
39.8
95
132
H50.9
ICD-10 Finland
Strabismus, unspecified
185.6
34.9
36
*
XCK00
NOMESCO Finland
Perimetry
4.4
34.3
132
328
H52.0
ICD-10 Finland
Hypermetropia
35.1
34.3
44
13
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
33.5
32
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
32.9
496
2966
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
41.4
32.3
40
10
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
31.4
30
*
CE2W4
NOMESCO Finland
Eye movement mapping
159.1
29.8
31
*
WX140
NOMESCO Finland
Parabulbar anesthesy
5.2
29.6
95
195
H50.4
ICD-10 Finland
Other and unspecified heterotropia
299.2
28.9
29
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
19.4
28.4
43
23
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
48.4
27.6
33
7
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
27.2
26
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
26.8
130
396
H52.1
ICD-10 Finland
Myopia
11.6
24.8
46
41
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.0
24.2
393
2343
H53.0
ICD-10 Finland
Amblyopia ex anopsia
19.5
24.0
36
19
H03BB01
ATC
carbimazole; oral
4.8
23.9
82
181
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
23.0
22
*
3780B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALTERNANS]
+∞
23.0
22
*
H50.50
ICD-10 Finland
Alternating hyperphoria
122.5
22.7
24
*
H52.2
ICD-10 Finland
Astigmatism
21.2
22.6
33
16
3504
FHL
Retroposition of two muscles
+∞
21.9
21
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
6.1
21.9
60
102
CEC50
NOMESCO Finland
Advancement of extraocular muscle
+∞
20.9
20
*
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
48.9
20.2
24
5
H05.2
ICD-10 Finland
Exophthalmic conditions
36.5
19.9
25
7
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
18.8
18
*
ZXA00
NOMESCO Finland
Right side
1.9
18.8
316
1875
H50.51
ICD-10 Finland
Esophoria
71.1
18.8
21
*
N07AA02
ATC
pyridostigmine; systemic
19.1
18.7
28
15
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.3
18.7
97
311
H062, E050
ICD-10 Finland
NA
53.4
18.0
21
*
3501
FHL
Myotomy or tenotomy
+∞
17.7
17
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
17.7
17
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
17.7
17
*
AA1AD
NOMESCO Finland
CT of head and brain
2.0
17.1
257
1453
3780A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONCOMITANS CONVERGENS]
+∞
16.7
16
*
3505
FHL
Single muscle resection
+∞
16.7
16
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.0
16.7
54
113
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.5
15.8
131
563
F95
ICPC
Strabismus
60.9
15.8
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
15.7
314
1960
ZXA10
NOMESCO Finland
Bilateral
2.0
15.7
213
1153
G70.0
ICD-10 Finland
Myasthenia gravis
19.5
15.6
23
12
Z3231
NOMESCO Finland
Registered nurse
1.8
15.5
325
2062
ZXA05
NOMESCO Finland
Left side
1.9
15.3
286
1740
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
14.9
146
683
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
14.8
115
477
3781B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]
+∞
14.6
14
*
3507
FHL
Retroposition and resection
151.8
14.5
15
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.5
13.7
107
446
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
9.8
13.2
26
27
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
12.5
12
*
3781A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]
+∞
12.5
12
*
H51.8
ICD-10 Finland
Other specified disorders of binocular movement
+∞
12.5
12
*
3510
FHL
Cardiac surgery on three or more muscles
+∞
12.5
12
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
131.4
12.5
13
*
H03AA01
ATC
levothyroxine sodium; systemic
1.8
12.2
257
1612
108
Kela drug reimbursment
Myasthenia gravis
16.1
12.2
19
12
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
21.5
12.0
17
8
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
12.0
101
437
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
11.9
134
665
XCK10
NOMESCO Finland
Photography of fundus of eye
2.2
11.9
119
563
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
8.0
11.9
26
33
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
65.6
11.6
13
*
3782B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS DIVERGENS INTERMITTENS]
+∞
11.5
11
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
11.5
384
2738
ZXD20
NOMESCO Finland
Day surgery
2.0
10.6
144
774
H02.4
ICD-10 Finland
Ptosis of eyelid
4.2
10.6
39
95
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
10.6
75
297
TAB00
NOMESCO Finland
Lumbar puncture
3.1
10.4
57
192
H25.0
ICD-10 Finland
Senile incipient cataract
2.8
10.4
65
238
CS494
NOMESCO Finland
Other visual field testing
4.1
10.2
38
94
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
10.0
108
526
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
7.5
9.7
22
30
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.5
201
1253
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
9.5
306
2143
3508
FHL
Transposition or anteposition
+∞
9.4
9
*
CEC40
NOMESCO Finland
Resection and advancement of extraocular muscle
+∞
9.4
9
*
H53.3
ICD-10 Finland
Other disorders of binocular vision
13.8
9.2
15
11
H26.4
ICD-10 Finland
After-cataract
2.2
9.1
90
424
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.3
9.0
83
378
CAC10
NOMESCO Finland
Reconstruction of orbital wall using bone graft or plate
37.0
9.0
11
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
4.6
9.0
30
67
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.5
8.8
40
118
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
8.6
92
449
WX402
NOMESCO Finland
General anaesthesia
1.7
8.6
172
1055
CAC44
NOMESCO Finland
Combined decompression of orbit
90.7
8.4
9
*
CEC80
NOMESCO Finland
Partial transposition of extraocular muscle
+∞
8.3
8
*
37304
ICD-8 Finland
Strabismus, paralyticus. Paresis nervorum III, IV, VI
+∞
8.3
8
*
3784B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Heterophoria[EXOPHORIA]
+∞
8.3
8
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
8.2
254
1753
Z2445
NOMESCO Finland
Psychologist
2.7
8.2
56
217
R42
ICD-10 Finland
Dizziness and giddiness
1.6
8.2
211
1388
H33.0
ICD-10 Finland
Retinal detachment with retinal break
3.5
8.1
36
105
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
8.0
104
548
BAA60
NOMESCO Finland
Total thyroidectomy
3.5
7.4
33
97
CAC20
NOMESCO Finland
Lateral decompression of orbit
80.6
7.4
8
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.8
7.4
29
77
CEC85
NOMESCO Finland
Combined correction of cyclodeviation
+∞
7.3
7
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
7.3
7
*
CEE00
NOMESCO Finland
Posterior fixation suture of extraocular muscle
+∞
7.3
7
*
XA800
NOMESCO Finland
Neuropsychological investigation
2.7
7.2
47
179
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
7.1
525
4314
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.9
7.0
41
146
S02.30
ICD-10 Finland
Fracture of orbital floor, closed
7.0
7.0
16
23
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.2
7.0
66
305
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
6.9
152
956
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
6.7
6.8
16
24
H50.59
ICD-10 Finland
Heterophor UNS
40.3
6.8
8
*
WX110
NOMESCO Finland
Local anesthesy
1.4
6.8
720
6280
A02BC05
ATC
esomeprazole; systemic
1.4
6.7
385
3009
N06AX11
ATC
mirtazapine; oral
1.5
6.7
310
2329
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
4.9
6.7
20
41
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
22.7
6.7
9
*
ZXE00
NOMESCO Finland
One hour or less
1.4
6.6
409
3240
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.6
209
1446
R20.2
ICD-10 Finland
Paraesthesia of skin
2.1
6.6
69
337
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
6.5
383
3009
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.1
6.5
33
109
H50.39
ICD-10 Finland
Intermittent heterotropia
70.2
6.4
7
*
CA1AD
NOMESCO Finland
Orbita CT
14.4
6.4
10
7
J01DB01
ATC
cefalexin; oral
1.4
6.4
857
7747
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
6.3
131
809
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
6.3
121
732
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
11.1
6.3
11
10
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.9
6.3
83
444
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
4.3
6.2
21
49
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.2
399
3178
R01AD09
ATC
mometasone; nasal
1.4
6.1
447
3634
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
6.1
198
1375
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
12.6
6.1
10
8
104
Kela drug reimbursment
Thyroid insufficiency
2.0
6.1
74
385
R62.0
ICD-10 Finland
Delayed milestone
8.6
6.1
12
14
CKC60
NOMESCO Finland
Local buckling of sclera using implant
10.1
6.0
11
11
S18
ICPC
Laceration/cut
1.4
6.0
394
3144
Mortality – FinRegistry
↥Association
Association between endpoint H7_VERTISTRAB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VERTISTRAB | 0.921 [0.77, 1.09] | 0.349 |
| Birth year | 0.992 [0.98, 1.0] | 0.078 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 3370 females with H7_VERTISTRAB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VERTISTRAB | 1.046 [0.89, 1.23] | 0.586 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 2894 males with H7_VERTISTRAB died.
Mortality risk
Mortality risk for people of age
years, who have H7_VERTISTRAB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.086% | 0.209% |
| 5 | 0.507% | 1.234% |
| 10 | 1.248% | 2.985% |
| 15 | 2.428% | 5.589% |
| 20 | 4.468% | 9.332% |
Relationships between endpoints
↥Index endpoint: H7_VERTISTRAB – Vertical strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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