No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1596 |
4. Check minimum number of eventsNone |
1596 |
5. Include endpointsNone |
1596 |
6. Filter based on genotype QC (FinnGen only) |
1560 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H83
- Name in latin
- Laesio auris internae e strepitu
Similar endpoints
↥List of similar endpoints to
Noise effects on inner ear
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13487 | 861 | 12565 |
| Only index persons | 12716 | 844 | 11872 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.02 | 0.35 |
| Only index persons | 0.43 | 0.03 | 0.45 |
| Median age at first event (years) | |||
| Whole population | 53.71 | 51.05 | 53.80 |
| Only index persons | 52.85 | 51.01 | 52.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1560 | 133 | 1427 |
| Unadjusted period prevalence (%) | 0.60 | 0.05 | 0.65 |
| Median age at first event (years) | 56.48 | 48.42 | 57.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1596
- Matched controls
- 15960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
9.5
307.7
818
1597
H83.3
ICD-10 Finland
Noise effects on inner ear
10211.4
307.7
1526
34
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
7.8
201.0
313
483
DFF00
NOMESCO Finland
Pure tone audiometry
6.4
198.3
394
782
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.9
161.8
449
1181
UDC00
NOMESCO Finland
Ear microscopy
5.9
135.7
273
538
DFF15
NOMESCO Finland
Speech audiometry
7.2
135.3
219
347
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.7
125.3
214
358
DAX08
NOMESCO Finland
Fitting of hearing aid
6.2
118.4
222
407
H93.1
ICD-10 Finland
Tinnitus
5.3
102.6
226
479
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.6
88.6
182
361
Z57.0
ICD-10 Finland
Occupational exposure to noise
218.7
81.1
83
*
3881A
ICD-9 Finland
Other disorders of ear, Noise effects on inner ear
+∞
72.4
69
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.8
71.7
137
253
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
6.3
67.0
118
201
N07CA01
ATC
betahistine; oral
3.8
43.6
144
411
SPAT1043
SPAT
Audiometry
3.0
41.6
210
778
W34
ICD-10 Finland
Discharge from other and unspecified firearms
79.0
41.1
46
6
H02
ICPC
Hearing complaint
2.6
39.7
268
1153
W42
ICD-10 Finland
Exposure to noise
+∞
34.5
33
*
W3388, ,
ICD-10 Finland
+∞
33.4
32
*
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.3
29.6
117
374
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
25.6
251
1257
WX720
NOMESCO Finland
Own respiration
3.1
24.5
107
363
WX704
NOMESCO Finland
Intubation
2.4
20.5
148
650
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
3.0
18.6
86
301
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
18.5
109
434
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
5.9
18.4
33
57
H29
ICPC
Ear symptom/complaint other
2.2
18.3
175
863
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
18.1
222
1202
H03
ICPC
Tinnitus, ringing/buzzing ear
3.9
16.4
49
130
H81.3
ICD-10 Finland
Other peripheral vertigo
6.7
15.8
25
38
M03BX02
ATC
tizanidine; oral
1.5
15.6
895
7234
ZXE10
NOMESCO Finland
More than one and less than three hours
0.6
14.8
231
3709
R5120
NOMESCO Finland
Preparation of an aid
3.0
13.7
60
204
SPAT1263
SPAT
Sampling
1.5
13.1
561
4212
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.8
13.0
219
1306
ZXD10
NOMESCO Finland
Scheduled procedure
0.6
12.9
254
3859
H91.1
ICD-10 Finland
Presbycusis
2.3
12.7
99
449
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
12.6
99
450
WX702
NOMESCO Finland
Supraglottic ventilation device
2.4
12.6
90
393
OAA80, ,
SPAT
1.9
12.6
179
1014
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.7
12.6
68
260
H81.0
ICD-10 Finland
Ménière disease
20.2
12.5
18
9
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
12.4
375
2603
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.1
12.2
121
604
L15
ICPC
Knee symptom/complaint
1.6
12.2
289
1890
R4135
NOMESCO Finland
Rehabilitation for hearing problems
3.8
12.1
37
100
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
12.1
71
283
R42
ICD-10 Finland
Dizziness and giddiness
1.7
11.6
259
1667
N02BE01
ATC
paracetamol; systemic, rectal
1.6
11.6
1311
11831
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
11.5
315
2132
ZXE00
NOMESCO Finland
One hour or less
0.6
11.4
268
3924
R4110, ,
SPAT
2.0
10.5
111
569
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
10.4
327
2282
WX419
NOMESCO Finland
Other general anesthesy
4.9
10.3
22
45
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
10.2
277
1869
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
10.1
276
1865
T70.0
ICD-10 Finland
Otitic barotrauma
20.2
9.8
14
7
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
9.7
361
2608
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
9.6
113
601
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
9.5
560
4410
H91.8
ICD-10 Finland
Other specified hearing loss
4.5
9.3
22
49
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
9.0
1344
12374
Z2221
NOMESCO Finland
Medical doctor
0.6
9.0
158
2506
L01
ICPC
Neck symptom/complaint
1.7
8.8
168
1034
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
8.8
579
4629
XCW10
NOMESCO Finland
Assessment of vision
4.0
8.8
24
60
N03AX12
ATC
[U] gabapentin; oral
1.6
8.7
218
1439
T15.0
ICD-10 Finland
Foreign body in cornea
2.1
8.6
86
431
R01AD58
ATC
fluticasone, combinations; nasal
1.5
8.6
283
1985
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
8.6
245
1666
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
8.6
609
4925
M01AH05
ATC
etoricoxib; oral
1.4
8.4
865
7412
L08
ICPC
Shoulder symptom/complaint
1.5
8.4
283
1998
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
8.3
120
684
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
8.3
991
8690
M02AA10
ATC
ketoprofen; topical
1.6
8.2
204
1346
L13
ICPC
Hip symptom/complaint
1.6
8.1
198
1300
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.9
493
3891
J01DB01
ATC
cefalexin; oral
1.4
7.8
1205
10955
SFA10
NOMESCO Finland
One-surface restoration
1.3
7.7
744
6280
H81.2
ICD-10 Finland
Vestibular neuronitis
15.1
7.7
12
8
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
7.6
146
900
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.7
7.6
134
807
J34.2
ICD-10 Finland
Deviated nasal septum
1.8
7.6
108
612
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.4
7.6
49
206
R5140, ,
SPAT
4.4
7.4
18
41
Y89.1
ICD-10 Finland
Sequelae of war operations
13.4
7.4
12
9
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
+∞
7.3
7
*
KMAK, ,
NOMESCO Finland
1.3
7.2
682
5720
S61.0
ICD-10 Finland
Open wound of finger(s) without damage to nail
1.6
7.2
160
1025
DJD20
NOMESCO Finland
Plastic repair of septum of nose
2.0
7.2
79
412
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.6
7.1
183
1214
SPAT1301
SPAT
No procedures
1.4
7.0
382
2939
Z3231
NOMESCO Finland
Registered nurse
0.7
7.0
196
2803
WW200, ,
SPAT
1.4
6.9
303
2242
SPAT1097
SPAT
Recording of ECG
1.5
6.8
193
1311
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.8
6.6
93
526
R01AD09
ATC
mometasone; nasal
1.3
6.6
539
4414
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
6.5
226
1598
DFX03
NOMESCO Finland
Review, maintenance and user education for hearing aid
5.7
6.5
17
30
N32.0
ICD-10 Finland
Bladder-neck obstruction
3.5
6.4
21
60
R51.80
ICD-10 Finland
Headache
1.6
6.4
160
1054
NBL22
NOMESCO Finland
Myotomy, tenotomy or excision of tendon of upper arm
2.7
6.4
33
124
R03AC02
ATC
salbutamol; inhalant
1.3
6.4
671
5683
M54.5
ICD-10 Finland
Low back pain
1.4
6.4
439
3498
L17
ICPC
Foot/toe symptom/complaint
1.4
6.4
334
2548
R4110
NOMESCO Finland
Physiotherapy
0.7
6.4
196
2758
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.4
489
3963
R04
ICPC
Breathing problem other
2.2
6.4
51
236
R05
ICPC
Cough
1.4
6.3
260
1900
SFA30
NOMESCO Finland
Three-surface restoration
1.3
6.3
583
4848
H90
ICD-10 Finland
Conductive and sensorineural hearing loss
8.2
6.3
13
16
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.6
6.3
128
802
H13
ICPC
Plugged feeling ear
1.4
6.3
265
1946
RF313, ,
NOMESCO Finland
11.1
6.3
11
10
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
6.3
869
7633
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
1.5
6.3
171
1150
H01
ICPC
Ear pain/earache
1.7
6.2
113
688
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
6.2
745
6418
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
6.1
479
3887
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
6.1
612
5142
XA402
NOMESCO Finland
ENMG
2.6
6.1
33
128
M79.6
ICD-10 Finland
Pain in limb
1.3
6.1
490
3996
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
1.7
6.0
102
609
M54.2
ICD-10 Finland
Cervicalgia
1.7
6.0
97
572
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
260
1496
1.88
17.63
5.0
4.5
31.74
30.63
%
0.91
194
1046
93
355
2.72
17.17
6.9
8.3
104.55
105.75
mmol/l
1.08
87
313
386
2591
1.65
15.03
3.5
3.5
1.02
1.02
kg/l
0.07
98
358
123
604
2.12
12.97
5.9
6.2
2.00
1.73
%
1.21
115
558
106
509
2.16
11.84
2.2
1.9
—
—
—
0
0
1386
12676
1.71
11.73
4.6
4.4
1.31
1.32
mmol/l
0.36
1313
11775
1410
12967
1.75
11.55
5.0
4.9
2.76
2.71
mmol/l
1.32
1335
12041
118
598
2.05
11.46
6.1
6.3
1.01
0.88
%
3.74
111
555
1391
12762
1.70
11.28
4.7
4.4
4.54
4.51
mmol/l
0.67
1320
11929
1458
13621
1.81
10.20
10.0
10.5
30.64
30.73
u/l
0.05
1427
13198
1340
12250
1.59
10.19
4.9
4.5
5.96
6.09
mmol/l
3.94
1256
11251
60
240
2.56
10.18
1.5
1.6
—
—
—
0
0
1344
12306
1.58
10.02
4.1
4.0
1.36
1.38
mmol/l
0.39
1273
11376
515
3970
1.44
9.89
3.1
2.7
58.16
79.83
u/l
0.55
483
3718
251
3602
0.64
9.43
3.3
3.3
0.33
0.42
e6/l
0.53
209
2814
124
2100
0.56
9.06
2.8
3.4
2.41
2.44
mmol/l
2.45
112
1844
978
8508
1.39
8.88
5.0
4.7
3.04
2.52
ug/l
0.26
920
7691
1497
14203
1.87
8.47
21.0
21.6
4.66
4.64
e12/l
0.94
1474
13821
1497
14206
1.87
8.42
21.2
21.6
6.81
6.82
e9/l
0.02
1471
13823
1497
14206
1.87
8.42
21.1
21.7
141.65
140.65
g/l
1.64
1486
14010
1494
14186
1.83
8.13
20.9
21.8
41.35
41.80
%
0.55
1304
13312
59
263
2.29
7.97
1.2
1.5
—
—
—
0
0
100
545
1.89
7.93
4.1
4.2
25.11
24.79
mmol/l
0.53
92
513
1493
14188
1.81
7.90
21.2
21.6
232.56
236.71
e9/l
1.77
1470
13854
74
1385
0.51
7.49
3.4
3.6
—
—
—
0
0
1284
11835
1.43
7.39
5.7
5.8
39.60
40.38
mmol/mol
2.70
1209
11064
1350
12575
1.48
7.22
14.5
15.1
25.05
27.02
mg/l
1.15
1087
10010
44
955
0.45
6.82
13.1
10.9
94.68
94.04
%
0.63
44
949
1387
13033
1.49
6.66
17.1
17.6
139.89
139.66
mmol/l
3.15
1361
12751
943
8351
1.32
6.54
3.2
3.2
14.74
14.84
pmol/l
0.60
851
7574
1391
13087
1.49
6.54
17.2
17.8
4.02
4.01
mmol/l
0.65
1362
12788
167
1119
1.55
6.23
2.8
2.8
196.01
209.77
ng/l
0.16
150
1015
47
953
0.48
6.06
12.3
10.7
1.56
1.37
%
0.84
47
947
867
7641
1.29
5.99
2.9
2.7
—
—
—
0
0
47
949
0.48
5.99
12.4
10.9
0.62
0.66
%
0.37
47
940
36
147
2.48
5.97
2.5
2.3
29.93
20.20
mg/l
0.45
15
37
1167
10739
1.32
5.64
4.0
3.8
1.92
2.06
mu/l
0.59
1058
9788
133
866
1.58
5.64
3.6
3.7
2.13
1.77
mmol/l
0.58
90
642
988
8919
1.28
5.37
4.4
3.9
9.47
11.22
mm/h
4.44
935
8289
138
918
1.55
5.34
3.7
3.8
5.14
5.15
kpa
0.06
132
875
1167
10786
1.30
5.16
16.1
17.8
16.16
15.29
%
1.12
1153
10597
73
1229
0.57
5.16
2.6
2.6
35.46
78.25
u/l
0.58
61
1081
586
4986
1.28
5.07
3.9
3.7
44.19
60.23
ng/l
0.75
417
3632
91
557
1.67
4.96
2.0
2.0
—
—
—
0
0
979
8870
1.27
4.96
3.5
3.3
51.99
57.54
u/l
1.38
937
8336
847
7570
1.25
4.72
4.2
3.9
3.43
1194.53
e6/l
—
7
122
83
511
1.66
4.46
1.9
1.8
—
—
—
0
0
768
6816
1.24
4.45
4.7
4.0
21.44
21.68
%
0.17
344
3189
163
2226
0.70
4.40
2.9
3.0
0.84
0.92
e6/l
0.17
114
1335
56
964
0.57
4.32
3.7
4.7
1.21
1.22
mmol/l
0.23
49
858
138
962
1.48
4.31
6.5
7.7
24.70
24.43
mmol/l
0.36
129
916
14
34
4.15
4.21
1.6
1.1
18.57
37.04
%
1.34
14
26
1047
9658
1.24
4.10
7.1
8.1
75.47
78.11
u/l
1.03
999
9204
27
117
2.33
4.02
1.3
1.4
—
—
—
0
0
31
145
2.16
3.88
1.2
1.6
—
—
—
0
0
31
145
2.16
3.88
1.2
1.6
—
—
—
0
0
36
674
0.52
3.73
3.6
4.4
24.01
24.11
mmol/l
0.07
36
664
50
844
0.58
3.62
10.5
9.3
23.77
24.61
mmol/l
0.70
50
838
30
143
2.12
3.60
1.2
1.6
—
—
—
0
0
30
143
2.12
3.60
1.2
1.5
—
—
—
0
0
12
330
0.36
3.38
4.8
5.5
5.04
5.04
kpa
0.01
12
325
27
127
2.15
3.36
1.3
1.3
45368.33
45229.67
e6/l
0.00
15
94
216
1699
1.31
3.31
1.3
1.2
55.37
30.18
iu/ml
0.73
67
520
499
4334
1.22
3.29
3.8
3.5
32.97
39.86
u/l
1.06
466
4110
332
3949
0.80
3.28
3.4
3.4
27.18
92.70
e6/l
3.16
283
3127
29
142
2.06
3.27
1.2
1.6
—
—
—
0
0
29
142
2.06
3.27
1.2
1.6
—
—
—
0
0
523
4573
1.21
3.21
3.6
3.4
—
—
—
0
0
644
5771
1.19
3.00
4.8
4.4
0.00
0.00
estimate
-0.00
60
1132
175
2229
0.76
2.99
3.0
3.8
0.81
0.82
mmol/l
0.45
165
2121
661
5938
1.19
2.99
7.3
8.0
1.21
1.20
mmol/l
3.20
581
5075
18
76
2.38
2.89
1.1
1.5
—
—
—
0
0
649
5834
1.19
2.89
3.4
3.3
0.02
0.00
estimate
0.46
65
1175
651
5858
1.19
2.85
3.4
3.3
0.00
0.00
estimate
0.50
54
1045
43
257
1.69
2.69
1.0
1.1
—
—
—
0
0
688
6243
1.18
2.69
14.2
16.3
1.30
1.32
inr
0.20
183
1811
213
1722
1.27
2.67
1.5
1.4
—
—
—
0
0
46
282
1.65
2.63
1.1
1.1
6.84
3.60
u/ml
—
5
31
5
164
0.30
2.55
1.4
2.0
—
—
—
0
0
548
4906
1.18
2.47
1.9
2.0
97.75
92.79
pmol/l
1.58
303
2821
168
2095
0.78
2.45
3.3
3.2
0.94
0.74
e6/l
0.44
117
1208
17
76
2.25
2.44
1.1
1.5
—
—
—
0
0
0
66
0.00
2.40
0.0
1.0
—
—
—
0
0
227
2727
0.80
2.40
2.5
2.7
2.90
3.28
e6/l
0.53
211
2483
98
1301
0.74
2.27
3.7
4.1
5.85
5.85
kpa
0.01
93
1263
16
325
0.49
2.24
1.4
1.6
—
—
—
0
0
195
1595
1.25
2.23
1.3
1.2
12.15
8.84
u/ml
0.24
67
638
598
5434
1.16
2.18
6.0
7.2
1.21
1.20
mmol/l
1.35
537
5001
73
520
1.42
2.16
3.4
2.9
—
—
—
0
0
434
3849
1.18
2.16
2.1
2.3
218.86
301.65
u/l
0.87
405
3624
10
37
2.71
2.07
1.2
1.1
—
—
—
0
0
161
1302
1.26
2.05
2.2
2.6
104.71
169.54
ug/g
2.34
132
1077
0
58
0.00
2.04
0.0
1.5
—
87.01
—
0
58
299
2584
1.19
2.01
4.5
3.8
670.03
585.55
ng/l
0.09
232
2097
100
1297
0.76
1.99
3.5
4.2
2.04
1.83
mmol/l
0.24
80
1082
449
4990
0.86
1.97
2.9
2.9
0.70
0.74
ug/l
0.53
271
3223
8
27
2.97
1.93
1.5
1.9
1.20
1.20
mmol/l
—
8
27
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
518
0.63
1.90
2.4
2.9
0.38
0.33
u/ml
0.36
22
290
12
253
0.47
1.90
1.2
1.3
—
—
—
0
0
423
4710
0.86
1.89
3.2
3.4
—
—
—
0
0
260
2231
1.20
1.89
1.5
1.7
885.00
1146.96
nmol/l
7.03
211
1749
13
264
0.49
1.86
1.3
1.3
—
—
—
0
0
13
264
0.49
1.86
1.3
1.3
—
—
—
0
0
10
223
0.44
1.85
2.0
3.1
3.02
119.27
u/ml
—
10
218
18
326
0.55
1.81
1.4
1.6
—
—
—
0
0
28
168
1.68
1.81
1.1
1.1
—
—
—
0
0
154
1262
1.24
1.77
1.6
1.8
—
—
—
0
0
25
148
1.70
1.71
1.7
1.4
74.25
60.39
%
1.23
20
100
628
5813
1.13
1.65
3.0
2.7
—
—
—
0
0
101
794
1.29
1.65
2.7
2.3
22.95
21.13
au/ml
—
6
48
20
341
0.58
1.64
2.0
2.7
0.07
0.00
g/l
0.48
20
316
28
439
0.63
1.64
1.4
1.4
—
—
—
0
0
225
1934
1.19
1.62
2.0
2.3
13.58
13.79
nmol/l
0.16
203
1747
5
14
3.58
1.61
1.2
1.2
2.13
2.06
umol/24h
—
5
14
20
338
0.59
1.60
2.0
2.7
0.00
0.00
g/l
-0.00
20
316
267
3038
0.85
1.57
2.7
2.5
—
—
—
0
0
702
6559
1.13
1.56
6.0
6.9
11.97
12.59
umol/l
0.90
671
6273
64
476
1.36
1.55
1.1
1.0
—
—
—
0
0
22
130
1.70
1.53
1.2
1.5
1.06
1.28
promille
0.25
16
100
10
205
0.48
1.51
1.3
1.8
—
—
—
0
0
127
1531
0.81
1.43
2.0
2.5
1.85
1.75
%
0.40
116
1374
9
39
2.31
1.43
1.1
1.2
—
—
—
0
0
0
37
0.00
1.34
0.0
1.3
—
—
—
0
0
12
61
1.97
1.33
1.2
1.6
—
—
—
0
0
12
61
1.97
1.33
1.2
1.6
—
—
—
0
0
241
2128
1.16
1.27
2.0
1.9
—
—
—
0
0
48
356
1.36
1.23
1.1
1.3
—
—
—
0
0
5
19
2.64
1.21
1.6
1.2
—
—
—
0
0
628
5896
1.11
1.21
5.4
6.3
57.25
57.67
%
0.40
592
5585
41
297
1.39
1.21
2.4
2.3
136.00
131.11
g/l
0.65
29
213
366
3337
1.13
1.20
1.9
1.7
1.41
1.46
mmol/l
0.47
320
2793
13
224
0.58
1.17
2.8
2.1
1.60
1.66
mmol/l
0.07
13
215
6
127
0.47
1.17
3.8
2.1
831.50
646.54
ml
—
6
74
438
4046
1.11
1.14
3.3
3.4
579.18
288.08
mg/l
0.54
291
2843
70
555
1.27
1.14
2.0
1.8
34.12
38.80
u/l
1.24
64
491
5
114
0.44
1.12
1.4
1.8
—
—
—
0
0
21
135
1.56
1.11
1.2
1.4
0.55
0.62
nmol/l
0.29
21
129
635
5986
1.10
1.11
5.5
6.5
27.62
26.92
%
0.86
602
5673
25
364
0.68
1.10
2.0
2.7
0.18
0.02
g/l
0.89
25
339
106
1261
0.83
1.09
1.8
2.4
6.71
8.70
ug/l
0.84
85
1157
41
304
1.36
1.08
1.4
1.1
—
—
—
0
0
16
254
0.63
1.07
3.0
4.0
55.38
57.36
%
0.26
16
254
280
2536
1.13
1.03
1.7
1.7
175104133.59
35625123.80
pmol/l
1.05
241
2153
464
4325
1.10
1.01
3.1
3.4
8.94
8.67
mmol/l
0.60
392
3679
165
1448
1.16
0.98
8.2
9.7
127.19
124.59
g/l
0.85
157
1405
16
248
0.64
0.98
1.8
2.0
—
—
—
0
0
16
246
0.65
0.95
2.9
3.7
3.58
4.33
e9/l
0.83
16
246
403
3746
1.10
0.93
3.0
3.1
1151.64
1590.13
ng/l
1.60
331
3233
109
1271
0.85
0.92
2.1
2.3
0.20
0.22
g/l
1.68
104
1179
9
52
1.73
0.92
1.4
2.9
—
—
—
0
0
393
3661
1.10
0.87
2.5
2.9
1133.53
5113.86
umol/l
3.58
363
3272
122
1401
0.86
0.86
6.7
8.5
10.14
10.37
mmol/l
0.14
117
1344
171
1916
0.88
0.86
2.4
2.8
2.32
2.26
g/l
0.81
159
1798
280
2567
1.11
0.85
1.6
1.7
0.94
1.39
mg/l
3.09
219
1969
353
3795
0.91
0.84
2.9
3.5
2.33
2.34
mmol/l
1.11
305
3365
32
422
0.75
0.83
1.6
1.7
—
—
—
0
0
6
113
0.53
0.83
1.0
1.2
—
—
—
0
0
798
7675
1.08
0.82
5.0
5.5
6.76
6.87
mmol/l
0.74
756
7257
40
311
1.29
0.81
1.5
1.3
—
—
—
0
0
92
1074
0.85
0.81
2.0
2.7
62.77
66.09
ml/min/173m2
0.31
40
400
30
397
0.75
0.81
2.7
2.2
167.08
111.16
ug/min
0.17
20
243
34
441
0.77
0.80
1.5
1.7
2.64
4.78
mg/l
1.15
22
323
8
48
1.67
0.78
1.3
1.1
—
—
—
0
0
7
123
0.57
0.78
1.6
1.9
—
—
—
0
0
5
100
0.50
0.77
1.0
1.2
43.06
59.57
u/l
—
5
93
23
166
1.39
0.75
1.1
1.1
—
—
—
0
0
44
351
1.26
0.75
2.5
2.1
—
—
—
0
0
175
1578
1.12
0.73
7.7
9.0
96.49
95.62
%
1.44
165
1519
451
4259
1.08
0.73
3.7
4.0
6.27
10.23
mg/mmol
1.95
305
2948
135
1515
0.88
0.72
2.6
3.1
7.53
9.46
umol/l
0.95
125
1356
9
57
1.58
0.71
2.1
2.5
—
—
—
0
0
9
57
1.58
0.71
2.1
2.5
—
—
—
0
0
9
58
1.55
0.69
2.1
2.5
—
—
—
0
0
9
144
0.62
0.69
2.8
4.2
—
—
—
0
0
5
27
1.85
0.68
1.0
1.1
—
—
—
0
0
165
1822
0.89
0.68
2.5
2.8
23.36
23.96
%
0.19
112
1580
7
117
0.60
0.68
1.0
1.3
—
—
—
0
0
18
128
1.41
0.65
2.1
2.8
—
—
—
0
0
7
44
1.59
0.65
1.3
1.1
—
—
—
0
0
20
146
1.37
0.64
1.1
1.1
0.21
2.87
u/ml
3.39
11
72
32
402
0.79
0.62
2.9
3.0
1.64
1.57
mg/l
0.18
27
365
11
72
1.53
0.59
1.1
1.3
—
—
—
0
0
40
327
1.23
0.58
2.3
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
13
89
1.46
0.58
1.5
2.1
—
—
—
0
0
6
35
1.72
0.57
1.5
1.6
—
—
—
0
0
7
116
0.60
0.57
1.1
1.3
—
180.00
—
0
24
33
407
0.81
0.56
1.5
1.4
5.38
6.06
u/l
0.37
28
331
107
957
1.13
0.55
2.3
1.8
—
—
—
0
0
53
622
0.85
0.55
4.3
4.0
50.13
49.94
%
0.02
53
614
186
1715
1.10
0.55
7.6
8.7
1.28
0.90
mmol/l
0.59
142
1359
12
82
1.47
0.54
1.0
1.2
—
—
—
0
0
34
276
1.24
0.54
1.3
1.2
—
354.00
—
0
10
9
61
1.48
0.53
1.7
1.5
—
—
—
0
0
6
39
1.54
0.53
1.0
1.3
472.50
143.78
nmol/l
—
6
26
44
369
1.20
0.52
1.2
1.1
—
0.77
—
0
6
283
3004
0.93
0.52
2.1
2.1
2.90
2.93
mg/l
0.06
254
2570
43
360
1.20
0.52
1.2
1.4
—
—
—
0
0
12
83
1.45
0.52
1.0
1.2
—
—
—
0
0
44
521
0.84
0.51
1.9
2.4
233.76
680.48
ug/l
2.05
44
498
57
660
0.86
0.51
1.4
1.8
1.44
1.54
g/l
0.39
52
572
90
801
1.13
0.51
4.1
5.1
101.36
104.37
ng/l
0.08
81
712
42
499
0.84
0.51
2.6
4.0
141.20
4233.31
u/ml
0.99
35
417
11
75
1.47
0.50
1.2
1.1
—
—
—
0
0
11
75
1.47
0.50
1.5
1.4
—
—
—
0
0
9
65
1.39
0.50
1.0
1.4
—
258.57
—
0
7
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
32
261
1.23
0.50
3.1
3.6
6.86
7.63
mmol/l
1.06
32
255
91
1017
0.89
0.50
2.3
2.8
10.25
10.75
g/l
0.48
82
938
71
624
1.14
0.49
1.8
2.0
2.03
1.96
ug/l
0.02
60
566
26
323
0.80
0.49
1.5
1.6
203.85
259.56
mu/l
1.61
26
300
7
46
1.52
0.48
1.0
1.1
1351.29
1319.54
miu/ml
—
7
46
185
1718
1.09
0.48
7.7
8.7
12.06
12.12
kpa
0.07
172
1647
185
1718
1.09
0.48
7.6
8.7
4.99
5.11
kpa
1.12
171
1644
41
346
1.19
0.47
1.6
1.5
285.00
260.23
ug/g
0.39
23
216
7
49
1.43
0.46
1.1
1.1
—
—
—
0
0
18
138
1.31
0.45
1.2
1.1
—
—
—
0
0
8
121
0.66
0.45
1.1
1.5
—
—
—
0
0
30
247
1.22
0.44
1.3
1.2
1.62
5.07
u/ml
—
5
17
16
208
0.77
0.44
1.1
1.7
—
—
—
0
0
15
113
1.33
0.42
1.3
1.6
88.00
87.65
umol/l
0.02
15
113
25
203
1.24
0.42
1.2
1.1
0.92
2.00
u/ml
0.70
16
102
23
283
0.81
0.41
1.2
1.2
288.14
297.68
u/ml
0.07
14
182
38
323
1.18
0.41
2.5
1.7
0.81
0.84
nmol/l
0.12
33
285
5
33
1.52
0.41
1.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
206.07
—
0
15
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
448
4316
1.05
0.40
2.0
2.2
73.03
74.49
nmol/l
0.57
406
3887
16
123
1.30
0.40
1.1
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
114
1049
1.09
0.39
2.3
1.9
—
—
—
0
0
294
2804
1.06
0.38
1.6
1.6
18.77
19.12
nmol/l
0.16
249
2429
27
224
1.21
0.38
3.3
2.9
0.71
0.83
nmol/l
1.01
27
171
12
159
0.75
0.38
1.2
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
67
1.35
0.38
1.3
1.1
—
—
—
0
0
13
169
0.77
0.37
1.3
1.5
24197.50
63061.06
e6/l
—
8
109
16
202
0.79
0.37
1.0
1.1
—
—
—
0
0
33
281
1.18
0.36
2.9
2.1
—
—
—
0
0
25
299
0.83
0.36
1.1
1.2
—
—
—
0
0
6
43
1.40
0.35
1.3
1.1
—
—
—
0
0
28
236
1.19
0.35
1.5
1.9
—
—
—
0
0
28
236
1.19
0.35
1.5
1.9
—
—
—
0
0
331
3178
1.05
0.35
3.4
3.6
0.00
0.00
estimate
0.69
56
1037
10
73
1.37
0.34
1.3
1.1
—
—
—
0
0
29
338
0.86
0.32
1.4
1.3
1.25
1.15
g/l
1.07
29
325
21
174
1.21
0.31
1.0
1.1
2.11
1.66
u/ml
0.08
11
84
24
283
0.85
0.31
1.4
1.5
126.00
122.33
u/ml
—
7
53
32
277
1.16
0.30
1.3
1.2
3.47
3.87
mmol/l
1.53
25
258
18
147
1.23
0.30
1.2
1.0
—
—
—
0
0
11
84
1.31
0.30
1.1
1.0
—
—
—
0
0
7
56
1.25
0.29
1.4
1.2
—
—
—
0
0
7
57
1.23
0.29
1.0
5.9
—
—
—
0
0
32
279
1.15
0.28
1.3
1.3
213.55
195.55
miu/ml
0.09
11
113
15
121
1.24
0.28
1.4
1.4
—
—
—
0
0
28
323
0.86
0.28
1.5
1.3
0.24
0.25
g/l
0.13
28
309
8
62
1.29
0.28
1.3
1.1
—
—
—
0
0
47
522
0.90
0.28
1.4
1.2
82.80
137.43
iu/ml
0.86
20
172
162
1537
1.06
0.27
4.9
7.3
—
—
—
0
0
32
280
1.15
0.27
3.1
3.5
1.49
1.64
mmol/l
0.80
32
273
5
74
0.67
0.26
1.8
2.9
—
—
—
0
0
11
138
0.80
0.25
2.0
2.4
—
—
—
0
0
9
73
1.23
0.25
2.1
2.3
—
—
—
0
0
9
73
1.23
0.25
2.1
2.3
—
—
—
0
0
24
207
1.16
0.25
1.3
1.5
135.22
210.83
pmol/l
0.92
24
207
23
266
0.86
0.25
1.5
1.7
—
—
—
0
0
45
407
1.11
0.24
1.6
1.6
35.11
1.81
iu/ml
0.50
11
90
19
161
1.18
0.24
3.4
5.6
7.29
7.40
mmol/l
0.07
14
136
5
38
1.32
0.23
1.4
1.1
—
—
—
0
0
5
39
1.28
0.23
1.4
1.1
—
—
—
0
0
101
1071
0.94
0.23
2.4
2.2
443.91
363.69
nmol/l
1.39
94
999
19
163
1.17
0.21
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
5.1
—
421.18
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
19.03
—
0
11
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
93
877
1.06
0.21
1.5
1.7
—
—
—
0
0
206
2136
0.96
0.21
1.4
1.5
2.47
2.73
g/l
0.88
126
1391
454
4638
0.97
0.20
2.5
2.8
159.96
182.93
ug/l
1.43
428
4303
0
14
0.00
0.20
0.0
1.4
—
16.71
—
0
14
9
111
0.81
0.20
1.4
1.2
—
—
—
0
0
19
165
1.15
0.19
1.2
1.7
—
—
—
0
0
19
165
1.15
0.19
1.2
1.7
—
—
—
0
0
167
1607
1.04
0.19
3.8
4.3
255.79
239.31
u/l
0.67
161
1535
196
2028
0.96
0.18
1.8
2.0
1.40
1.56
%
2.47
174
1791
24
213
1.13
0.18
1.6
1.9
6.17
6.13
iu/l
—
10
73
7
58
1.21
0.18
1.4
2.6
—
34310.07
—
0
14
17
148
1.15
0.17
1.8
2.0
—
—
—
0
0
102
1068
0.95
0.16
2.0
2.8
65.76
66.37
g/l
0.32
92
995
231
2247
1.03
0.16
1.3
1.2
1.99
1.49
u/ml
0.39
50
612
74
781
0.94
0.16
1.8
1.5
—
—
—
0
0
29
318
0.91
0.16
1.2
1.1
—
—
—
0
0
6
76
0.79
0.15
1.0
1.1
—
—
—
0
0
6
76
0.79
0.15
1.0
1.1
—
—
—
0
0
6
76
0.79
0.15
1.0
1.1
—
—
—
0
0
9
80
1.13
0.15
1.3
1.1
—
—
—
0
0
704
7116
0.98
0.13
7.4
9.8
4.14
4.26
e9/l
0.51
636
6241
18
161
1.12
0.13
1.8
1.9
—
—
—
0
0
24
219
1.10
0.12
1.1
1.5
—
—
—
0
0
51
483
1.06
0.12
1.4
1.2
—
—
—
0
0
35
327
1.07
0.11
1.3
1.7
—
—
—
0
0
1200
12057
0.98
0.11
12.8
13.9
80.42
82.14
ml/min/173m2
1.98
949
10040
29
312
0.93
0.11
1.4
1.5
—
14.97
—
0
7
200
2045
0.97
0.11
2.3
2.8
12.87
13.41
umol/l
0.53
191
1931
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
21
194
1.08
0.09
1.1
1.6
—
—
—
0
0
30
318
0.94
0.08
1.2
1.1
—
—
—
0
0
5
60
0.83
0.08
1.8
1.5
6.80
1.41
u/field
—
5
44
5
64
0.78
0.08
1.2
1.2
143.60
179.73
iu/ml
—
5
64
7
68
1.03
0.07
2.7
4.4
—
—
—
0
0
6
73
0.82
0.07
2.0
1.7
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
149
1461
1.02
0.07
1.9
1.8
—
—
—
0
0
33
347
0.95
0.07
1.5
1.9
—
—
—
0
0
41
393
1.04
0.07
2.3
3.1
24.20
24.80
mmol/l
0.39
41
387
29
275
1.06
0.06
3.5
3.3
41.29
29.15
mg/l
0.72
14
171
9
100
0.90
0.06
1.0
1.5
0.87
0.96
g/l
—
9
100
11
121
0.91
0.06
1.0
1.5
—
—
—
0
0
10
90
1.11
0.05
1.0
1.0
—
—
—
0
0
85
868
0.98
0.05
3.9
3.4
133.60
129.99
g/l
0.70
78
847
14
150
0.93
0.04
1.1
1.1
—
—
—
0
0
26
250
1.04
0.03
1.1
1.6
—
—
—
0
0
78
793
0.98
0.03
1.8
1.6
—
—
—
0
0
148
1467
1.01
0.02
1.9
1.8
—
—
—
0
0
20
207
0.97
0.01
1.1
1.1
—
—
—
0
0
27
277
0.97
0.01
1.4
1.3
33.10
38.81
e6/l
0.07
21
215
27
277
0.97
0.01
1.4
1.4
218.00
1468.72
e6/l
1.03
21
222
34
333
1.02
0.01
1.5
1.9
—
—
—
0
0
12
126
0.95
0.00
1.9
1.9
—
—
—
0
0
12
126
0.95
0.00
1.9
1.9
—
—
—
0
0
12
126
0.95
0.00
1.9
1.9
—
—
—
0
0
127
1263
1.01
0.00
3.3
4.7
7.13
23.34
ug/l
1.50
93
1065
538
5388
1.00
0.00
5.4
5.7
35.95
35.45
g/l
1.23
513
5055
12
116
1.03
0.00
1.2
1.3
—
—
—
0
0
34
338
1.01
0.00
1.8
1.4
—
—
—
0
0
23
229
1.00
0.00
1.1
1.1
26.43
86.31
iu/ml
—
7
52
48
481
1.00
0.00
1.8
2.7
—
—
—
0
0
215
2148
1.00
0.00
1.7
2.2
29.43
30.10
s
0.96
202
2095
54
535
1.01
0.00
3.2
3.7
4.56
4.51
pmol/l
0.16
49
487
18
185
0.97
0.00
1.1
1.1
14.55
6.07
u/ml
0.46
12
94
0
8
0.00
0.00
0.0
1.4
—
2.13
—
0
8
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
720.56
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
2.0
2.5
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.4
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.8
—
—
—
0
0
9
92
0.98
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
8
87
0.92
-0.00
1.0
1.3
1.57
1.50
g/l
—
8
87
5
53
0.94
-0.00
1.4
1.2
203.20
197.09
mmol/24h
—
5
53
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
9.50
—
0
6
0
9
0.00
-0.00
0.0
6.3
—
—
—
0
0
7
74
0.95
-0.00
1.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
8.36
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
22.10
—
0
7
0
6
0.00
-0.00
0.0
4.2
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
38.96
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
68.82
—
0
5
6
68
0.88
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
11.6
—
—
—
0
0
5
58
0.86
-0.00
1.2
2.2
468.20
1295.45
u/ml
—
5
58
5
50
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_NOISEINNER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_NOISEINNER | 0.93 [0.69, 1.25] | 0.628 |
| Birth year | 0.998 [0.99, 1.01] | 0.64 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 717 females with H8_NOISEINNER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_NOISEINNER | 0.788 [0.72, 0.86] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 1579 out of 10010 males with H8_NOISEINNER died.
Mortality risk
Mortality risk for people of age
years, who have H8_NOISEINNER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.183% |
| 5 | 0.599% | 1.04% |
| 10 | 1.384% | 2.658% |
| 15 | 2.62% | 5.003% |
| 20 | 4.996% | 8.654% |
Relationships between endpoints
↥Index endpoint: H8_NOISEINNER – Noise effects on inner ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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