No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1544 |
4. Check minimum number of eventsNone |
1544 |
5. Include endpointsNone |
1544 |
6. Filter based on genotype QC (FinnGen only) |
1544 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H83
- Name in latin
- Laesio auris internae e strepitu
Similar endpoints
↥List of similar endpoints to
Noise effects on inner ear
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13487 | 861 | 12565 |
| Only index persons | 12716 | 844 | 11872 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.02 | 0.35 |
| Only index persons | 0.43 | 0.03 | 0.45 |
| Median age at first event (years) | |||
| Whole population | 53.71 | 51.05 | 53.80 |
| Only index persons | 52.85 | 51.01 | 52.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1544 | 131 | 1413 |
| Unadjusted period prevalence (%) | 0.57 | 0.04 | 0.62 |
| Median age at first event (years) | 56.33 | 47.34 | 57.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1365
- Matched controls
- 13650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.3
ICD-10 Finland
Noise effects on inner ear
10704.9
323.0
1300
20
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
9.3
261.1
658
1237
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.6
112.1
373
852
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
8.3
110.3
264
383
DFF00
NOMESCO Finland
Pure tone audiometry
5.8
85.3
265
540
3881A
ICD-9 Finland
Other disorders of ear, Noise effects on inner ear
+∞
67.2
64
*
Z57.0
ICD-10 Finland
Occupational exposure to noise
332.0
64.0
64
*
DFF15
NOMESCO Finland
Speech audiometry
7.4
59.7
150
225
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.7
59.5
160
264
UDC00
NOMESCO Finland
Ear microscopy
5.1
58.2
198
437
H93.1
ICD-10 Finland
Tinnitus
4.9
50.5
179
410
W34
ICD-10 Finland
Discharge from other and unspecified firearms
216.4
41.1
42
*
DAX08
NOMESCO Finland
Fitting of hearing aid
5.8
38.0
112
206
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.3
33.6
107
216
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.2
32.0
89
152
W42
ICD-10 Finland
Exposure to noise
168.9
31.8
33
*
W3388
ICD-10 Finland
NA
+∞
29.3
28
*
H02
ICPC
Hearing complaint
2.8
27.8
193
752
N07CA01
ATC
betahistine; oral
3.8
27.2
122
345
SPAT1043
SPAT
Audiometry
2.9
26.2
171
638
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
5.9
24.6
70
124
H91.9
ICD-10 Finland
Hearing loss, unspecified
4.4
22.7
84
199
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
18.4
198
966
R5120
NOMESCO Finland
Preparation of an aid
4.7
15.5
53
117
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
3.5
13.8
64
188
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
8.9
13.0
27
31
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
12.8
92
364
M03BX02
ATC
tizanidine; oral
1.5
12.5
736
5947
H29
ICPC
Ear symptom/complaint other
2.3
12.5
123
570
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
12.5
172
923
WX704
NOMESCO Finland
Intubation
2.4
11.9
104
457
T70.0
ICD-10 Finland
Otitic barotrauma
121.0
11.4
12
*
H81.3
ICD-10 Finland
Other peripheral vertigo
8.6
10.5
22
26
H91.1
ICD-10 Finland
Presbycusis
2.6
10.5
74
291
XG410
NOMESCO Finland
Flow-volume spirometry
2.8
10.1
64
237
H81.0
ICD-10 Finland
Ménière disease
16.8
9.9
15
9
WX720
NOMESCO Finland
Own respiration
2.7
9.7
65
247
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.2
9.5
98
469
N02BE01
ATC
paracetamol; systemic, rectal
1.5
9.4
1046
9359
H03
ICPC
Tinnitus, ringing/buzzing ear
3.8
9.3
38
102
SPAT1263
SPAT
Sampling
1.5
9.3
468
3582
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
9.2
286
1967
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.7
9.2
217
1390
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.0
200
1258
M02AA10
ATC
ketoprofen; topical
1.8
9.0
172
1033
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
8.9
805
6870
L13
ICPC
Hip symptom/complaint
1.9
8.8
138
776
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
8.5
604
4917
N03AX12
ATC
gabapentin; oral
1.7
8.5
163
982
WX419
NOMESCO Finland
Other general anesthesy
6.7
8.4
20
30
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
8.2
1121
10267
L08
ICPC
Shoulder symptom/complaint
1.6
8.1
205
1333
Y89.1
ICD-10 Finland
Sequelae of war operations
22.2
8.0
11
5
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
8.0
442
3427
R05
ICPC
Cough
1.6
7.8
206
1358
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.1
7.7
86
426
H81.2
ICD-10 Finland
Vestibular neuronitis
45.2
7.7
9
*
T15.0
ICD-10 Finland
Foreign body in cornea
2.2
7.6
73
337
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.7
7.5
50
193
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.5
426
3309
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
7.4
295
2135
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
7.3
64
286
M01AH05
ATC
etoricoxib; oral
1.4
7.3
670
5652
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
7.0
191
1267
M01AB05
ATC
diclofenac; systemic, rectal
1.4
6.8
798
6963
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.8
236
1660
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
1.7
6.7
145
906
L15
ICPC
Knee symptom/complaint
1.6
6.6
193
1302
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.5
524
4302
A02BC03
ATC
lansoprazole; oral
1.4
6.4
302
2259
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.5
6.3
235
1675
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
6.3
400
3154
R4110
NOMESCO Finland
Physiotherapy
0.6
6.3
148
2158
KMAK
NOMESCO Finland
NA
1.3
6.2
575
4815
M01AX05
ATC
glucosamine; oral
1.6
6.2
176
1180
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
6.1
450
3636
M54.2
ICD-10 Finland
Cervicalgia
2.0
6.0
69
348
L01
ICPC
Neck symptom/complaint
1.7
6.0
119
725
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
260
1441
1.97
19.95
5.0
4.5
31.8
30.6
%
1.05
192
995
366
2531
1.58
12.37
3.5
3.5
1.0
1.0
kg/l
0.06
95
351
116
583
2.07
11.53
6.0
6.2
2.0
1.7
%
1.05
108
538
1337
12250
1.68
10.86
4.6
4.4
1.3
1.3
mmol/l
0.26
1263
11361
1360
12528
1.72
10.69
5.0
4.9
2.8
2.7
mmol/l
1.45
1283
11616
1342
12335
1.67
10.43
4.7
4.5
4.5
4.5
mmol/l
0.80
1270
11513
99
488
2.10
10.37
2.2
1.8
—
—
—
0
0
501
3849
1.45
9.88
3.1
2.7
58.2
58.2
u/l
0.00
468
3598
1294
11845
1.57
9.57
4.9
4.5
6.0
6.1
mmol/l
3.72
1212
10868
1407
13163
1.78
9.43
10.1
10.5
30.6
30.7
u/l
0.08
1376
12749
244
3516
0.64
9.40
3.3
3.3
0.3
0.4
e6/l
0.55
200
2713
1296
11896
1.56
9.16
4.1
4.0
1.4
1.4
mmol/l
0.31
1226
10990
119
2031
0.55
8.97
2.8
3.3
2.4
2.4
mmol/l
2.23
107
1788
56
234
2.45
8.71
1.6
1.6
—
—
—
0
0
59
254
2.38
8.61
1.2
1.5
—
—
—
0
0
99
523
1.95
8.60
4.2
4.1
25.1
24.8
mmol/l
0.47
91
492
945
8255
1.37
8.16
5.0
4.7
3.1
2.5
ug/l
0.27
887
7457
1445
13728
1.82
7.75
21.3
21.6
4.7
4.6
e12/l
0.80
1422
13357
1445
13731
1.82
7.70
21.4
21.7
141.6
140.6
g/l
1.52
1434
13538
1445
13733
1.81
7.67
21.4
21.6
6.8
6.8
e9/l
0.02
1419
13359
72
1343
0.51
7.23
3.4
3.6
—
—
—
0
0
1441
13715
1.76
7.17
21.4
21.6
232.6
236.6
e9/l
1.60
1418
13389
111
1817
0.58
7.09
7.7
7.9
105.4
104.4
mmol/l
1.64
101
1775
913
8074
1.32
6.48
3.2
3.2
14.8
14.8
pmol/l
0.37
823
7319
44
932
0.46
6.41
13.1
10.9
94.7
94.0
%
0.68
44
927
1303
12181
1.45
6.38
14.7
15.1
25.2
27.0
mg/l
1.00
1048
9695
1236
11454
1.40
6.30
5.7
5.9
39.7
40.4
mmol/mol
2.31
1162
10701
36
143
2.55
6.30
2.5
2.4
29.9
20.5
mg/l
0.43
15
36
131
832
1.63
6.15
3.7
3.7
2.1
1.8
mmol/l
0.58
88
617
161
1085
1.54
5.88
2.8
2.8
191.9
212.9
ng/l
0.26
144
985
838
7380
1.30
5.86
2.9
2.7
—
—
—
0
0
1338
12616
1.45
5.82
17.3
17.6
139.9
139.7
mmol/l
2.80
1312
12333
14
32
4.41
5.77
1.6
1.1
18.6
36.0
%
1.21
14
25
1342
12666
1.46
5.75
17.4
17.8
4.0
4.0
mmol/l
0.43
1313
12367
47
932
0.49
5.70
12.3
10.7
1.6
1.4
%
0.84
47
926
47
928
0.49
5.63
12.4
10.8
0.6
0.7
%
0.34
47
919
135
883
1.58
5.62
3.7
3.7
5.1
5.2
kpa
0.08
128
813
1128
10372
1.32
5.55
4.0
3.9
1.9
2.1
mu/l
0.66
1019
9440
960
8642
1.29
5.51
4.4
3.9
9.5
11.3
mm/h
4.35
908
8031
1210
11249
1.35
5.46
15.4
15.8
40.9
41.2
%
0.39
825
8188
575
4855
1.29
5.43
3.9
3.7
44.1
61.2
ng/l
0.79
405
3537
90
540
1.71
5.27
2.0
2.0
—
—
—
0
0
947
8567
1.27
4.94
3.5
3.3
52.1
57.4
u/l
1.25
906
8044
72
1193
0.58
4.81
2.6
2.6
35.7
79.9
u/l
0.58
60
1049
82
493
1.70
4.79
1.9
1.8
—
—
—
0
0
825
7358
1.26
4.78
4.3
4.0
3.4
1225.4
e6/l
—
7
119
53
936
0.55
4.48
3.8
4.5
1.2
1.2
mmol/l
0.22
47
835
159
2178
0.70
4.39
2.9
3.0
0.8
0.9
e6/l
0.18
110
1308
31
139
2.26
4.26
1.2
1.6
—
—
—
0
0
31
139
2.26
4.26
1.2
1.6
—
—
—
0
0
1015
9357
1.25
4.05
7.2
8.0
75.7
78.2
u/l
0.92
964
8899
133
933
1.47
4.05
6.6
7.7
24.7
24.4
mmol/l
0.34
122
869
30
137
2.21
3.97
1.2
1.6
—
—
—
0
0
30
137
2.21
3.97
1.2
1.6
—
—
—
0
0
26
112
2.34
3.93
1.3
1.4
—
—
—
0
0
738
6620
1.22
3.66
4.6
4.1
21.4
21.6
%
0.16
331
3096
29
136
2.15
3.62
1.2
1.6
—
—
—
0
0
29
136
2.15
3.62
1.2
1.6
—
—
—
0
0
213
1655
1.33
3.57
1.3
1.2
56.1
32.9
iu/ml
0.64
66
501
50
815
0.60
3.20
10.5
9.3
23.8
24.6
mmol/l
0.73
50
810
481
4182
1.22
3.15
3.8
3.5
33.2
40.3
u/l
1.05
449
3964
18
74
2.45
3.05
1.1
1.5
—
—
—
0
0
26
128
2.05
2.92
1.3
1.3
48608.0
47502.0
e6/l
0.01
14
94
642
5769
1.19
2.91
7.4
7.9
1.2
1.2
mmol/l
3.60
558
4905
46
274
1.70
2.89
1.1
1.1
6.8
2.5
u/ml
—
5
29
537
4763
1.20
2.79
1.9
2.0
97.8
92.5
pmol/l
1.68
297
2745
42
251
1.69
2.64
1.0
1.1
—
—
—
0
0
26
134
1.96
2.61
1.2
1.2
6.5
7.5
mmol/l
1.00
17
108
73
500
1.48
2.59
3.4
2.9
—
—
—
0
0
17
74
2.31
2.58
1.1
1.5
—
—
—
0
0
502
4452
1.19
2.57
3.6
3.4
—
—
—
0
0
90
1237
0.71
2.56
8.0
8.4
1.4
1.4
mmol/l
0.06
84
1194
193
1550
1.28
2.56
1.3
1.2
12.3
9.7
u/ml
0.18
66
623
94
1274
0.72
2.47
3.7
4.1
5.9
5.8
kpa
0.03
89
1236
50
762
0.64
2.45
11.6
11.6
23.5
24.2
mmol/l
0.69
44
716
0
63
0.00
2.43
0.0
1.0
—
—
—
0
0
10
34
2.95
2.41
1.2
1.1
—
—
—
0
0
620
5621
1.17
2.41
4.8
4.4
0.0
0.0
estimate
0.00
58
1095
5
162
0.31
2.40
1.4
2.0
—
—
—
0
0
221
2660
0.80
2.39
2.6
2.7
2.9
3.2
e6/l
0.48
197
2364
173
2141
0.78
2.38
3.0
3.8
0.8
0.8
mmol/l
0.98
162
2035
584
5275
1.17
2.37
6.1
7.1
1.2
1.2
mmol/l
1.52
515
4821
165
2049
0.78
2.34
3.3
3.2
1.0
0.7
e6/l
0.69
114
1183
627
5701
1.17
2.33
3.4
3.3
0.0
0.0
estimate
0.50
53
1014
623
5662
1.17
2.33
3.4
3.3
0.0
0.0
estimate
0.49
52
1053
157
1246
1.29
2.30
2.2
2.6
109.5
170.9
ug/g
1.99
126
1019
15
315
0.47
2.30
1.4
1.6
—
—
—
0
0
96
1268
0.74
2.16
3.6
4.1
1.8
1.8
mmol/l
0.03
70
1015
290
2487
1.20
2.12
4.5
3.8
683.2
585.7
ng/l
0.10
223
2020
254
2152
1.22
2.11
1.6
1.8
892.4
1141.1
nmol/l
6.23
205
1688
422
3744
1.17
2.10
2.0
2.3
221.6
303.5
u/l
0.83
394
3528
0
55
0.00
2.07
0.0
1.4
—
89.9
—
0
55
101
768
1.34
2.04
2.7
2.3
23.3
22.1
au/ml
—
6
35
43
646
0.66
2.02
3.3
2.8
0.7
0.7
%
0.27
43
619
8
26
3.09
2.01
1.5
1.8
1.2
1.2
mmol/l
—
8
26
12
257
0.46
1.97
1.3
1.3
—
—
—
0
0
12
257
0.46
1.97
1.3
1.3
—
—
—
0
0
25
144
1.75
1.85
1.7
1.5
74.3
60.7
%
1.19
20
100
64
460
1.41
1.84
1.1
1.0
—
—
—
0
0
198
1664
1.22
1.80
1.5
1.4
—
—
—
0
0
414
4596
0.86
1.78
3.2
3.4
—
—
—
0
0
685
6366
1.14
1.73
6.0
6.9
12.0
12.6
umol/l
0.87
651
6086
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
505
0.65
1.72
2.4
2.9
0.4
0.3
u/ml
0.36
22
282
148
1212
1.24
1.72
1.6
1.8
—
—
—
0
0
439
4842
0.87
1.72
3.0
2.9
0.7
0.7
ug/l
0.53
266
3128
18
320
0.56
1.71
1.4
1.6
—
—
—
0
0
10
213
0.47
1.66
2.0
3.1
3.0
126.8
u/ml
—
10
204
5
14
3.58
1.61
1.2
1.2
2.1
2.1
umol/24h
—
5
14
12
237
0.50
1.61
1.2
1.3
—
—
—
0
0
26
160
1.64
1.56
1.1
1.1
—
—
—
0
0
20
335
0.59
1.55
2.0
2.7
0.1
0.0
g/l
0.48
20
310
28
430
0.64
1.52
1.4
1.4
—
—
—
0
0
20
332
0.60
1.51
2.0
2.7
0.0
0.0
g/l
0.00
20
310
122
1485
0.81
1.50
2.0
2.5
1.9
1.7
%
0.45
111
1330
10
202
0.49
1.46
1.3
1.8
—
—
—
0
0
9
38
2.38
1.45
1.1
1.2
—
—
—
0
0
12
59
2.04
1.43
1.2
1.6
—
—
—
0
0
12
59
2.04
1.43
1.2
1.6
—
—
—
0
0
235
2063
1.16
1.34
2.0
1.9
—
—
—
0
0
48
352
1.38
1.30
1.1
1.3
—
—
—
0
0
262
2941
0.87
1.30
2.7
2.5
—
—
—
0
0
5
18
2.78
1.28
1.6
1.2
—
—
—
0
0
601
5620
1.11
1.28
4.9
4.2
—
—
—
0
0
215
1882
1.17
1.28
2.0
2.3
13.5
13.8
nmol/l
0.17
191
1686
12
216
0.55
1.25
3.0
2.1
1.6
1.7
mmol/l
0.05
12
208
21
133
1.59
1.17
1.2
1.4
0.6
0.6
nmol/l
0.30
21
127
0
36
0.00
1.14
0.0
1.3
—
—
—
0
0
103
1234
0.82
1.13
1.7
2.4
6.8
8.8
ug/l
0.78
83
1132
5
112
0.44
1.13
1.4
1.8
—
—
—
0
0
273
2460
1.13
1.09
1.7
1.7
152542775.5
36716545.4
pmol/l
0.84
236
2089
384
3532
1.12
1.09
2.4
2.9
1157.4
4945.1
umol/l
3.20
352
3132
68
542
1.27
1.08
1.9
1.8
33.8
38.8
u/l
1.37
62
481
20
129
1.56
1.05
1.2
1.5
1.2
1.3
promille
0.07
14
100
39
288
1.36
1.05
2.5
2.4
137.2
131.3
g/l
0.85
28
207
6
125
0.48
1.04
3.8
2.1
831.5
655.6
ml
—
6
72
25
358
0.69
1.03
2.0
2.7
0.2
0.0
g/l
0.88
25
333
449
4185
1.10
0.99
3.1
3.4
9.0
8.7
mmol/l
0.78
377
3538
9
50
1.80
0.96
1.4
3.0
—
—
—
0
0
16
247
0.64
0.96
3.0
3.8
55.4
57.3
%
0.25
16
247
352
3245
1.11
0.96
1.8
1.7
1.4
1.5
mmol/l
0.27
306
2710
394
3656
1.10
0.95
3.0
3.1
1130.2
1557.2
ng/l
1.56
326
3163
160
1406
1.15
0.94
8.3
9.6
127.2
124.6
g/l
0.78
147
1348
27
374
0.72
0.94
1.9
2.6
38.1
37.6
g/l
0.12
22
327
39
295
1.33
0.93
1.4
1.1
—
—
—
0
0
28
384
0.72
0.92
2.7
2.3
167.1
108.2
ug/min
0.18
20
233
16
244
0.65
0.92
1.7
2.0
—
—
—
0
0
15
94
1.60
0.90
1.4
2.3
14.4
13.6
%
—
10
38
23
160
1.44
0.89
1.1
1.1
—
—
—
0
0
89
1051
0.84
0.88
2.1
2.7
62.3
66.2
ml/min/173m2
0.36
39
395
775
7437
1.08
0.87
5.1
5.5
6.8
6.9
mmol/l
0.47
732
7018
16
239
0.67
0.85
2.9
3.5
3.6
4.3
e9/l
0.85
16
239
8
47
1.71
0.80
1.7
2.1
—
—
—
0
0
43
339
1.28
0.79
2.6
2.1
—
—
—
0
0
6
33
1.82
0.79
1.5
1.7
—
—
—
0
0
50
617
0.80
0.79
4.3
4.0
50.5
49.6
%
0.10
50
609
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
40
314
1.28
0.77
2.3
1.7
—
—
—
0
0
166
1845
0.89
0.75
2.5
2.8
2.3
2.3
g/l
0.52
154
1731
33
423
0.78
0.72
1.5
1.7
2.7
4.7
mg/l
0.96
21
297
9
56
1.61
0.72
2.1
2.6
—
—
—
0
0
9
56
1.61
0.72
2.1
2.6
—
—
—
0
0
6
110
0.54
0.72
1.2
1.3
—
—
—
0
0
271
2506
1.10
0.71
1.6
1.7
1.0
1.4
mg/l
2.93
211
1915
9
57
1.58
0.71
2.1
2.5
—
—
—
0
0
41
327
1.26
0.71
1.6
1.5
285.0
260.0
ug/g
0.39
23
205
437
4129
1.08
0.70
3.8
4.2
5.8
10.1
mg/mmol
2.51
297
2853
18
126
1.43
0.70
2.1
2.8
—
—
—
0
0
120
1354
0.88
0.70
6.8
8.4
10.1
10.4
mmol/l
0.19
115
1299
9
58
1.55
0.69
1.7
1.4
—
—
—
0
0
7
42
1.67
0.68
1.3
1.1
—
—
—
0
0
7
120
0.58
0.67
1.6
2.0
—
—
—
0
0
44
358
1.24
0.65
1.2
1.1
—
0.8
—
0
5
38
304
1.26
0.65
1.5
1.3
—
—
—
0
0
292
2723
1.09
0.65
1.6
1.6
18.6
19.2
nmol/l
0.28
247
2354
108
1220
0.88
0.65
2.1
2.3
0.2
0.2
g/l
2.00
103
1132
105
927
1.14
0.63
2.3
1.8
—
—
—
0
0
32
403
0.79
0.63
1.6
1.8
—
—
—
0
0
13
87
1.50
0.63
1.5
2.2
—
—
—
0
0
272
2916
0.92
0.63
2.1
2.1
2.9
2.9
mg/l
0.04
244
2491
34
270
1.27
0.62
1.3
1.2
—
388.9
—
0
9
12
79
1.52
0.62
1.0
1.2
—
—
—
0
0
11
71
1.55
0.62
1.1
1.3
—
—
—
0
0
70
601
1.17
0.61
1.8
2.0
2.1
2.0
ug/l
0.02
59
544
9
140
0.64
0.60
2.8
4.2
—
—
—
0
0
12
80
1.50
0.60
1.0
1.2
—
—
—
0
0
1029
10063
1.07
0.59
17.2
18.1
13.7
13.7
%
0.12
1011
9847
88
773
1.15
0.58
4.1
5.1
101.1
104.8
ng/l
0.10
79
689
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
7
115
0.61
0.58
1.1
1.3
—
185.7
—
0
23
7
115
0.61
0.58
1.0
1.3
—
—
—
0
0
439
4182
1.07
0.57
2.0
2.2
73.1
74.5
nmol/l
0.52
397
3766
38
311
1.23
0.56
2.5
1.7
0.8
0.8
nmol/l
0.09
33
273
133
1465
0.90
0.55
2.6
3.1
7.5
9.3
umol/l
0.84
123
1314
181
1667
1.10
0.55
7.7
8.6
1.2
0.9
mmol/l
0.47
135
1297
6
38
1.58
0.54
1.0
1.3
472.5
148.1
nmol/l
—
6
25
6
39
1.54
0.53
1.2
1.1
—
—
—
0
0
348
3668
0.93
0.53
2.9
3.5
2.3
2.3
mmol/l
1.06
297
3227
21
270
0.77
0.51
1.2
1.2
288.3
297.9
u/ml
0.06
13
172
161
1748
0.91
0.51
2.6
2.8
23.5
23.9
%
0.11
110
1514
11
75
1.47
0.50
1.2
1.1
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
—
—
—
0
0
42
353
1.20
0.49
1.2
1.4
—
—
—
0
0
7
45
1.56
0.49
1.0
1.0
1351.3
1304.6
miu/ml
—
7
45
180
1669
1.09
0.48
7.8
8.6
12.1
12.1
kpa
0.01
167
1599
180
1669
1.09
0.48
7.7
8.6
5.0
5.1
kpa
1.24
166
1596
32
388
0.82
0.48
2.9
3.0
1.6
1.6
mg/l
0.18
27
351
17
128
1.33
0.47
1.2
1.4
310.7
264.5
pmol/l
0.21
12
105
112
1018
1.11
0.46
2.4
1.9
—
—
—
0
0
30
246
1.22
0.45
1.3
1.2
1.6
5.0
u/ml
—
5
18
33
395
0.83
0.45
1.5
1.4
5.4
5.9
u/l
0.27
28
319
183
1706
1.08
0.44
19.7
25.6
1.7
1.3
inr
1.33
30
249
56
640
0.87
0.44
1.4
1.8
1.4
1.6
g/l
0.40
51
552
43
501
0.85
0.44
1.9
2.4
237.5
696.1
ug/l
2.02
43
479
23
285
0.80
0.43
1.1
1.2
—
—
—
0
0
15
196
0.76
0.43
1.0
1.1
—
—
—
0
0
5
32
1.56
0.42
1.0
1.4
—
—
—
0
0
10
70
1.43
0.41
1.3
1.1
—
—
—
0
0
16
206
0.77
0.41
1.1
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
206.1
—
0
15
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
2.7
—
—
—
0
0
0
16
0.00
0.41
0.0
2.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
24
196
1.23
0.39
1.2
1.1
1.2
1.9
u/ml
0.28
12
82
26
313
0.83
0.39
1.5
1.6
203.8
264.1
mu/l
1.79
26
291
32
270
1.19
0.38
2.9
2.1
—
—
—
0
0
9
66
1.37
0.38
1.0
1.4
—
258.6
—
0
7
5
36
1.39
0.38
1.4
1.1
—
—
—
0
0
42
482
0.87
0.37
2.6
4.0
141.2
4368.5
u/ml
0.99
35
404
8
114
0.70
0.37
1.1
1.5
—
—
—
0
0
5
37
1.35
0.37
1.4
1.1
—
—
—
0
0
93
850
1.10
0.37
1.5
1.7
—
—
—
0
0
17
134
1.27
0.37
1.2
1.1
—
—
—
0
0
9
70
1.29
0.36
2.1
2.4
—
—
—
0
0
9
70
1.29
0.36
2.1
2.4
—
—
—
0
0
9
70
1.29
0.36
2.1
2.4
—
—
—
0
0
9
70
1.29
0.36
2.1
2.4
—
—
—
0
0
11
81
1.36
0.36
1.1
1.0
—
—
—
0
0
24
199
1.21
0.35
1.3
1.5
64.9
202.2
pmol/l
0.46
12
64
12
156
0.77
0.34
1.2
1.2
—
—
—
0
0
15
118
1.27
0.33
1.4
1.4
—
—
—
0
0
13
166
0.78
0.33
1.3
1.5
24197.5
62468.2
e6/l
—
8
107
7
53
1.32
0.31
1.4
1.2
—
—
—
0
0
15
120
1.25
0.30
1.1
1.0
—
—
—
0
0
7
55
1.27
0.30
1.4
2.7
—
34310.1
—
0
14
7
57
1.23
0.29
1.0
5.9
—
—
—
0
0
29
334
0.87
0.29
1.4
1.3
1.3
1.2
g/l
1.11
29
321
30
261
1.15
0.27
3.0
3.6
6.7
7.6
mmol/l
1.81
30
255
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
65
1.23
0.27
1.4
1.1
—
—
—
0
0
5
71
0.70
0.26
1.8
3.1
—
—
—
0
0
28
320
0.87
0.26
1.5
1.3
0.2
0.2
g/l
0.11
28
306
9
72
1.25
0.25
1.4
1.4
—
—
—
0
0
439
4498
0.97
0.23
2.5
2.8
162.2
183.0
ug/l
1.18
413
4172
17
143
1.19
0.23
1.2
1.0
—
—
—
0
0
163
1558
1.05
0.23
3.8
4.2
257.5
240.0
u/l
0.71
157
1486
157
1500
1.05
0.22
5.0
7.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
5.1
—
391.9
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
25
220
1.14
0.21
3.0
2.8
0.7
0.8
nmol/l
1.04
25
167
0
13
0.00
0.21
0.0
1.5
—
17.3
—
0
13
30
268
1.12
0.20
1.4
1.2
3.5
3.9
mmol/l
1.49
25
249
17
145
1.17
0.20
1.8
2.0
—
—
—
0
0
23
261
0.88
0.20
1.5
1.7
—
—
—
0
0
6
48
1.25
0.20
1.2
1.1
—
—
—
0
0
72
768
0.93
0.20
1.8
1.5
—
—
—
0
0
43
395
1.09
0.19
1.6
1.6
35.1
1.9
iu/ml
0.50
11
85
225
2180
1.04
0.18
1.3
1.2
2.0
1.5
u/ml
0.42
48
599
18
156
1.16
0.18
1.8
2.0
—
—
—
0
0
7
60
1.17
0.17
1.3
1.1
—
—
—
0
0
46
496
0.93
0.17
1.4
1.2
87.1
136.5
iu/ml
0.71
19
164
18
157
1.15
0.17
1.2
1.1
—
—
—
0
0
24
268
0.89
0.17
1.4
1.5
126.0
122.6
u/ml
—
7
52
127
1218
1.05
0.17
3.3
4.6
7.1
24.1
ug/l
1.52
93
1024
24
215
1.12
0.16
1.1
1.5
—
—
—
0
0
18
158
1.14
0.16
3.6
5.7
7.0
7.4
mmol/l
0.34
13
133
50
467
1.07
0.16
1.4
1.2
—
—
—
0
0
35
322
1.09
0.15
1.4
1.7
—
—
—
0
0
81
851
0.95
0.15
3.9
3.4
133.2
130.1
g/l
0.55
74
830
9
80
1.13
0.15
1.3
1.1
—
—
—
0
0
100
1042
0.96
0.14
2.5
2.2
440.5
363.4
nmol/l
1.30
93
970
316
3097
1.03
0.14
3.4
3.6
0.0
0.0
estimate
0.69
54
1003
682
6894
0.98
0.13
7.5
9.7
4.1
4.3
e9/l
0.51
613
6038
190
1950
0.97
0.13
1.8
2.0
1.4
1.6
%
2.31
168
1719
23
209
1.10
0.13
1.5
1.9
6.2
6.0
iu/l
—
10
72
9
108
0.83
0.13
1.4
1.2
—
—
—
0
0
25
272
0.92
0.12
1.5
1.3
214.1
1495.3
e6/l
1.03
19
218
25
272
0.92
0.12
1.4
1.3
36.5
39.6
e6/l
0.04
19
210
21
191
1.10
0.11
1.1
1.6
—
—
—
0
0
29
269
1.08
0.11
1.2
1.3
112.3
198.6
miu/ml
—
9
111
33
353
0.93
0.11
2.5
2.9
30.6
37.7
umol/l
1.22
28
297
101
1044
0.97
0.11
2.0
2.8
65.8
66.4
g/l
0.28
91
971
30
280
1.07
0.10
3.0
3.5
1.5
1.6
mmol/l
0.56
30
273
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
211
2072
1.02
0.09
1.7
2.2
29.4
30.1
s
1.08
198
2019
6
56
1.07
0.08
2.0
2.5
—
—
—
0
0
194
1975
0.98
0.08
2.3
2.8
12.7
13.4
umol/l
0.69
182
1856
5
61
0.82
0.08
1.2
1.2
143.6
179.2
iu/ml
—
5
61
42
440
0.95
0.08
1.7
2.7
2.7
3.0
g/l
1.24
26
356
7
66
1.06
0.08
2.7
4.5
—
—
—
0
0
26
244
1.07
0.08
1.1
1.6
—
—
—
0
0
6
70
0.86
0.07
2.0
1.7
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
29
306
0.95
0.07
1.2
1.1
—
—
—
0
0
53
511
1.04
0.07
3.1
3.7
4.5
4.5
pmol/l
0.04
48
465
9
86
1.05
0.07
1.2
1.2
—
—
—
0
0
10
89
1.12
0.07
1.0
1.0
—
—
—
0
0
28
266
1.05
0.06
3.6
3.4
41.3
29.2
mg/l
0.71
14
167
144
1416
1.02
0.06
1.9
1.8
—
—
—
0
0
14
129
1.09
0.05
1.1
1.6
—
—
—
0
0
1161
11641
0.99
0.05
12.9
13.9
80.4
82.0
ml/min/173m2
1.72
924
9680
34
326
1.04
0.05
1.5
1.9
—
—
—
0
0
43
443
0.97
0.04
1.8
2.7
11.0
10.6
g/l
0.20
31
383
12
111
1.08
0.04
1.2
1.3
—
—
—
0
0
19
200
0.95
0.03
1.1
1.1
—
—
—
0
0
78
768
1.02
0.03
1.8
1.6
—
—
—
0
0
48
471
1.02
0.02
1.9
2.6
7.0
7.1
g/l
0.13
27
361
48
471
1.02
0.02
1.9
2.6
—
—
—
0
0
48
471
1.02
0.02
1.8
2.6
4.1
3.9
g/l
0.19
25
348
32
328
0.98
0.01
1.6
1.4
—
—
—
0
0
33
338
0.98
0.01
1.5
1.9
—
—
—
0
0
23
223
1.03
0.01
1.1
1.1
26.4
89.7
iu/ml
—
7
50
30
307
0.98
0.01
1.2
1.1
—
—
—
0
0
143
1422
1.01
0.01
1.9
1.8
—
—
—
0
0
14
144
0.97
0.00
1.1
1.1
—
—
—
0
0
12
122
0.98
0.00
1.9
1.9
—
—
—
0
0
12
122
0.98
0.00
1.9
1.9
—
—
—
0
0
12
122
0.98
0.00
1.9
1.9
—
—
—
0
0
521
5213
1.00
0.00
5.4
5.6
35.9
35.4
g/l
1.06
495
4888
29
295
0.98
0.00
1.4
1.5
—
15.0
—
0
7
0
5
0.00
0.00
0.0
1.0
—
11.4
—
0
5
6
67
0.90
0.00
1.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
12.9
—
—
—
0
0
6
67
0.90
0.00
1.0
1.4
—
—
—
0
0
6
67
0.90
0.00
1.0
1.4
—
—
—
0
0
5
59
0.85
0.00
1.8
1.5
6.8
1.4
u/field
—
5
43
9
95
0.95
0.00
1.0
1.5
0.9
1.0
g/l
—
9
95
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
22.1
—
0
7
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
7
73
0.96
0.00
1.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
720.6
—
0
9
0
9
0.00
0.00
0.0
1.4
—
20.6
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
2.1
—
0
8
0
9
0.00
0.00
0.0
6.3
—
—
—
0
0
5
54
0.93
0.00
1.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
39.0
—
0
7
0
5
0.00
0.00
0.0
7.2
—
82.0
—
0
5
5
58
0.86
0.00
1.2
2.1
468.2
1302.5
u/ml
—
5
58
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
68.8
—
0
5
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
8.4
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H8_NOISEINNER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_NOISEINNER | 0.93 [0.69, 1.25] | 0.628 |
| Birth year | 0.998 [0.99, 1.01] | 0.64 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 717 females with H8_NOISEINNER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_NOISEINNER | 0.788 [0.72, 0.86] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 1579 out of 10010 males with H8_NOISEINNER died.
Mortality risk
Mortality risk for people of age
years, who have H8_NOISEINNER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.183% |
| 5 | 0.599% | 1.04% |
| 10 | 1.384% | 2.658% |
| 15 | 2.62% | 5.003% |
| 20 | 4.996% | 8.654% |
Relationships between endpoints
↥Index endpoint: H8_NOISEINNER – Noise effects on inner ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data